Page last updated: 2024-09-04

atrasentan and ng-nitroarginine methyl ester

atrasentan has been researched along with ng-nitroarginine methyl ester in 8 studies

Compound Research Comparison

Studies
(atrasentan)
Trials
(atrasentan)
Recent Studies (post-2010)
(atrasentan)
Studies
(ng-nitroarginine methyl ester)
Trials
(ng-nitroarginine methyl ester)
Recent Studies (post-2010) (ng-nitroarginine methyl ester)
3584110812,6401172,342

Protein Interaction Comparison

ProteinTaxonomyatrasentan (IC50)ng-nitroarginine methyl ester (IC50)
Neutrophil elastaseHomo sapiens (human)2.7
Nitric oxide synthase, endothelialHomo sapiens (human)2.1
Nitric oxide synthase, brainHomo sapiens (human)1.1167
Nitric oxide synthase, inducibleMus musculus (house mouse)2.6
Nitric oxide synthase, inducibleHomo sapiens (human)8
Collagenase 3Homo sapiens (human)2.7

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (25.00)18.2507
2000's3 (37.50)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Opgenorth, TJ; Polakowski, JS; Pollock, DM; Wegner, CD1
Opgenorth, TJ; Polakowski, JS; Pollock, DM; Pollock, JS1
Banes, AK; Chen, AF; Fink, GD; Galligan, JJ; Li, L; Watts, SW1
Abassi, Z; Bishara, B; Hoffman, A; Karram, T; Khatib, S; Winaver, J1
Agharazii, M; Bélanger, S; Larivière, R; Lebel, M; Lemieux, P; Therrien, F1
Bkaily, G; Brochu, I; D'Orléans-Juste, P; Desbiens, L; Gobeil, F; Houde, M; Semaan, W; Simard, E1
Dobešová, Z; Kuneš, J; Vaněčková, I; Vernerová, Z; Zicha, J1
Abdelhady, SA; Darwish, IE; El-Deeb, NM; El-Mas, MM; Gowayed, MA; Habib, YH1

Other Studies

8 other study(ies) available for atrasentan and ng-nitroarginine methyl ester

ArticleYear
Beneficial effect of ETA receptor blockade in a rat model of radiocontrast-induced nephropathy.
    Renal failure, 1997, Volume: 19, Issue:6

    Topics: Acute Kidney Injury; Animals; Atrasentan; Contrast Media; Creatinine; Diatrizoate; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelins; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandin Antagonists; Proteinuria; Pyrrolidines; Rats; Rats, Sprague-Dawley; Stereoisomerism

1997
Role of endothelin ET(A) receptors in the hypertension produced by 4-day L-nitroarginine methyl ester and cyclosporine treatment.
    European journal of pharmacology, 1998, Apr-03, Volume: 346, Issue:1

    Topics: Animals; Atrasentan; Cyclosporine; Drinking Behavior; Endothelin Receptor Antagonists; Enzyme Inhibitors; Feeding Behavior; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin

1998
NADPH oxidase-derived superoxide augments endothelin-1-induced venoconstriction in mineralocorticoid hypertension.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:3

    Topics: Acetophenones; Allopurinol; Animals; Atrasentan; Desoxycorticosterone; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Superoxides; Vasoconstriction; Vasoconstrictor Agents; Venae Cavae; Viper Venoms; Xanthine Oxidase

2003
Adverse effects of pneumoperitoneum on renal function: involvement of the endothelin and nitric oxide systems.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:3

    Topics: Animals; Atrasentan; Blood Pressure; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelins; Enzyme Inhibitors; Glomerular Filtration Rate; Kidney; Kidney Function Tests; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitroglycerin; Pneumoperitoneum, Artificial; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Renal Circulation; Renal Plasma Flow; Vasodilator Agents

2008
Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat.
    European journal of pharmacology, 2009, Apr-01, Volume: 607, Issue:1-3

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Endothelin-1; Hydralazine; Hypertension, Malignant; Losartan; Male; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renal Insufficiency

2009
High salt-induced hypertension in B2 knockout mice is corrected by the ETA antagonist, A127722.
    British journal of pharmacology, 2013, Volume: 170, Issue:2

    Topics: Animals; Antihypertensive Agents; Arterial Pressure; Atrasentan; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin-1; Female; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Peptides, Cyclic; Pyrrolidines; Receptor, Bradykinin B2; Sodium; Sodium Chloride, Dietary; Telemetry

2013
Endothelin A receptor blocker atrasentan lowers blood pressure by the reduction of nifedipine-sensitive calcium influx in Ren-2 transgenic rats fed a high-salt diet.
    Journal of hypertension, 2015, Volume: 33, Issue:1

    Topics: Animal Feed; Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Calcium; Calcium Channels, L-Type; Captopril; Endothelin A Receptor Antagonists; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Pentolinium Tartrate; Pyrrolidines; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Renin-Angiotensin System; Sodium Chloride, Dietary; Sympathetic Nervous System; Vasoconstriction; Vasodilation

2015
Modulation by antenatal therapies of cardiovascular and renal programming in male and female offspring of preeclamptic rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:11

    Topics: Animals; Atrasentan; Cardiovascular Diseases; Disease Models, Animal; Endothelin A Receptor Antagonists; Female; Kidney Diseases; Male; Methyldopa; Naphthalenes; NG-Nitroarginine Methyl Ester; Pre-Eclampsia; Pregnancy; Prenatal Care; Propionates; Rats; Receptors, Thromboxane A2, Prostaglandin H2; Sex Factors; Sympatholytics

2021