atrasentan has been researched along with lu 135252 in 7 studies
| Studies (atrasentan) | Trials (atrasentan) | Recent Studies (post-2010) (atrasentan) | Studies (lu 135252) | Trials (lu 135252) | Recent Studies (post-2010) (lu 135252) |
|---|---|---|---|---|---|
| 358 | 41 | 108 | 196 | 13 | 14 |
| Protein | Taxonomy | atrasentan (IC50) | lu 135252 (IC50) |
|---|---|---|---|
| Endothelin receptor type B | Homo sapiens (human) | 0.016 | |
| Endothelin-1 receptor | Homo sapiens (human) | 0.0008 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berens, KL; Blok, N; Bourgoyne, AR; Brock, TA; Bui, H; Decker, ER; Dixon, RA; Holland, GW; Knowles, V; Wang, J; Wu, C; You, TJ | 1 |
| Deng, LY; Schiffrin, EL; Turgeon, A | 1 |
| Schiffrin, EL; Sharifi, AM | 1 |
| Li, JS; Schiffrin, EL; Turgeon, A | 1 |
| Austin, PC; Lapointe, N; Lee, DS; Nguyen, QT; Ohlsson, A; Rouleau, JL; Stewart, DJ; Tu, JV | 1 |
| Shi, GY | 1 |
| Cheng, G; Li, B; Li, Y; Liu, D; Lu, S; Xiao, J; Yuan, W; Zhao, Z | 1 |
2 review(s) available for atrasentan and lu 135252
| Article | Year |
|---|---|
Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failure.
Topics: Animals; Atrasentan; Cardiotonic Agents; Endothelin Receptor Antagonists; Heart Failure; Peptides, Cyclic; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Risk; Survival Rate | 2003 |
Endothelin-receptor antagonist can reduce blood pressure in patients with hypertension: a meta-analysis.
Topics: Antihypertensive Agents; Atrasentan; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Bosentan; Endothelin Receptor Antagonists; Humans; Hypertension; Middle Aged; Models, Statistical; Phenylpropionates; Pyridines; Pyrimidines; Pyrrolidines; Randomized Controlled Trials as Topic; Sulfonamides; Survival Analysis; Tetrazoles | 2017 |
1 trial(s) available for atrasentan and lu 135252
| Article | Year |
|---|---|
Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Humans; Isoxazoles; Ligands; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Structure-Activity Relationship; Sulfones | 2004 |
4 other study(ies) available for atrasentan and lu 135252
| Article | Year |
|---|---|
Effect of chronic ETA-selective endothelin receptor antagonism on blood pressure in experimental and genetic hypertension in rats.
Topics: Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Hemodynamics; Hypertension; Hypertension, Renovascular; Male; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Renin | 1997 |
Apoptosis in aorta of deoxycorticosterone acetate-salt hypertensive rats: effect of endothelin receptor antagonism.
Topics: Animals; Aorta; Apoptosis; Atrasentan; Desoxycorticosterone; Endothelin Receptor Antagonists; Hypertension; Male; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium Chloride | 1997 |
Effect of chronic treatment with two different ET(A) selective endothelin receptor antagonists on blood pressure and small artery structure of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
Topics: Animals; Arteries; Atrasentan; Blood Pressure; Desoxycorticosterone; Endothelin Receptor Antagonists; Hypertension; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sodium Chloride; Time Factors | 1998 |
[New choice of therapy of pulmonary hypertension: endothelin receptor antagonist].
Topics: Adult; Atrasentan; Bosentan; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phenylpropionates; Pyrimidines; Pyrrolidines; Sulfonamides | 2005 |