Page last updated: 2024-09-04

atrasentan and lu 135252

atrasentan has been researched along with lu 135252 in 7 studies

Compound Research Comparison

Studies
(atrasentan)
Trials
(atrasentan)
Recent Studies (post-2010)
(atrasentan)
Studies
(lu 135252)
Trials
(lu 135252)
Recent Studies (post-2010) (lu 135252)
358411081961314

Protein Interaction Comparison

ProteinTaxonomyatrasentan (IC50)lu 135252 (IC50)
Endothelin receptor type BHomo sapiens (human)0.016
Endothelin-1 receptorHomo sapiens (human)0.0008

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (42.86)18.2507
2000's3 (42.86)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berens, KL; Blok, N; Bourgoyne, AR; Brock, TA; Bui, H; Decker, ER; Dixon, RA; Holland, GW; Knowles, V; Wang, J; Wu, C; You, TJ1
Deng, LY; Schiffrin, EL; Turgeon, A1
Schiffrin, EL; Sharifi, AM1
Li, JS; Schiffrin, EL; Turgeon, A1
Austin, PC; Lapointe, N; Lee, DS; Nguyen, QT; Ohlsson, A; Rouleau, JL; Stewart, DJ; Tu, JV1
Shi, GY1
Cheng, G; Li, B; Li, Y; Liu, D; Lu, S; Xiao, J; Yuan, W; Zhao, Z1

Reviews

2 review(s) available for atrasentan and lu 135252

ArticleYear
Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failure.
    Journal of cardiac failure, 2003, Volume: 9, Issue:5

    Topics: Animals; Atrasentan; Cardiotonic Agents; Endothelin Receptor Antagonists; Heart Failure; Peptides, Cyclic; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Risk; Survival Rate

2003
Endothelin-receptor antagonist can reduce blood pressure in patients with hypertension: a meta-analysis.
    Blood pressure, 2017, Volume: 26, Issue:3

    Topics: Antihypertensive Agents; Atrasentan; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Bosentan; Endothelin Receptor Antagonists; Humans; Hypertension; Middle Aged; Models, Statistical; Phenylpropionates; Pyridines; Pyrimidines; Pyrrolidines; Randomized Controlled Trials as Topic; Sulfonamides; Survival Analysis; Tetrazoles

2017

Trials

1 trial(s) available for atrasentan and lu 135252

ArticleYear
Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.
    Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8

    Topics: Administration, Oral; Animals; Antihypertensive Agents; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Humans; Isoxazoles; Ligands; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Structure-Activity Relationship; Sulfones

2004

Other Studies

4 other study(ies) available for atrasentan and lu 135252

ArticleYear
Effect of chronic ETA-selective endothelin receptor antagonism on blood pressure in experimental and genetic hypertension in rats.
    British journal of pharmacology, 1997, Volume: 121, Issue:5

    Topics: Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Hemodynamics; Hypertension; Hypertension, Renovascular; Male; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Renin

1997
Apoptosis in aorta of deoxycorticosterone acetate-salt hypertensive rats: effect of endothelin receptor antagonism.
    Journal of hypertension, 1997, Volume: 15, Issue:12 Pt 1

    Topics: Animals; Aorta; Apoptosis; Atrasentan; Desoxycorticosterone; Endothelin Receptor Antagonists; Hypertension; Male; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium Chloride

1997
Effect of chronic treatment with two different ET(A) selective endothelin receptor antagonists on blood pressure and small artery structure of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.
    American journal of hypertension, 1998, Volume: 11, Issue:5

    Topics: Animals; Arteries; Atrasentan; Blood Pressure; Desoxycorticosterone; Endothelin Receptor Antagonists; Hypertension; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sodium Chloride; Time Factors

1998
[New choice of therapy of pulmonary hypertension: endothelin receptor antagonist].
    Zhonghua yi xue za zhi, 2005, Jan-26, Volume: 85, Issue:4

    Topics: Adult; Atrasentan; Bosentan; Endothelin Receptor Antagonists; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Phenylpropionates; Pyrimidines; Pyrrolidines; Sulfonamides

2005