Page last updated: 2024-09-04

atrasentan and allopurinol

atrasentan has been researched along with allopurinol in 2 studies

Compound Research Comparison

Studies
(atrasentan)
Trials
(atrasentan)
Recent Studies (post-2010)
(atrasentan)
Studies
(allopurinol)
Trials
(allopurinol)
Recent Studies (post-2010) (allopurinol)
3584110815,0967433,363

Protein Interaction Comparison

ProteinTaxonomyatrasentan (IC50)allopurinol (IC50)
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase Rattus norvegicus (Norway rat)3.3765
Xanthine dehydrogenase/oxidaseHomo sapiens (human)3.1861
Xanthine dehydrogenase/oxidaseBos taurus (cattle)5.0758
Histamine H3 receptorCavia porcellus (domestic guinea pig)8.69

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Banes, AK; Chen, AF; Fink, GD; Galligan, JJ; Li, L; Watts, SW1
Chen, CC; Hsu, YJ; Lee, TM1

Other Studies

2 other study(ies) available for atrasentan and allopurinol

ArticleYear
NADPH oxidase-derived superoxide augments endothelin-1-induced venoconstriction in mineralocorticoid hypertension.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:3

    Topics: Acetophenones; Allopurinol; Animals; Atrasentan; Desoxycorticosterone; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Superoxides; Vasoconstriction; Vasoconstrictor Agents; Venae Cavae; Viper Venoms; Xanthine Oxidase

2003
Impact of elevated uric acid on ventricular remodeling in infarcted rats with experimental hyperuricemia.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 301, Issue:3

    Topics: Allopurinol; Analysis of Variance; Animals; Antioxidants; Atrasentan; Biomarkers; Cyclic N-Oxides; Dinoprost; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin-1; Fibrosis; Gout Suppressants; Hypertrophy, Left Ventricular; Hyperuricemia; Isoprostanes; Male; Myocardial Infarction; Myocardium; Oxidative Stress; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; RNA, Messenger; Spin Labels; Superoxides; Time Factors; Up-Regulation; Uric Acid; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling; Xanthine Oxidase

2011