Page last updated: 2024-09-04

atrasentan and a 192621

atrasentan has been researched along with a 192621 in 43 studies

Compound Research Comparison

Studies (atrasentan)	Trials (atrasentan)	Recent Studies (post-2010) (atrasentan)	Studies (a 192621)	Trials (a 192621)	Recent Studies (post-2010) (a 192621)
358	41	108	84	0	8

Protein Interaction Comparison

Protein	Taxonomy	atrasentan (IC50)	a 192621 (IC50)
Endothelin receptor type B	Homo sapiens (human)		0.0051
Endothelin-1 receptor	Homo sapiens (human)		9.05

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.33)	18.2507
2000's	34 (79.07)	29.6817
2010's	8 (18.60)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Adler, A; Chiou, WJ; Dixon, DB; Marsh, KC; Nguyen, B; Opgenorth, TJ; Sorensen, BK; Szczepankiewicz, BG; Tasker, AS; von Geldern, TW; Wang, L; Wessale, JL; Winn, M	1
Calzadilla, SV; Dayton, BD; Jarvis, MF; Kowaluk, EA; Lynch, JJ; Opgenorth, TJ; Padley, RJ; Wessale, JL; Zhu, CZ	1
Burke, SE; Cox, BF; Ford, TT; Fu, KI; Lubbers, NL; Nelson, RA; Padley, RJ; Wegner, CD	1
Kobayashi, Y; Kohnou, K; Kuro, T; Matsumura, Y; Opgenorth, TJ; Takaoka, M; Wessale, JL	1
Boujedaini, H; Derumeaux, G; Henry, JP; Mulder, P; Opgenorth, T; Renet, S; Richard, V; Thuillez, C; Wessale, J	1
Adler, AL; Calzadilla, SV; Dixon, DB; Opgenorth, TJ; Padley, RJ; Wessale, JL; Wu-Wong, JR	1
Chiou, WJ; Dixon, DB; Jae, HS; Liu, G; Opgenorth, TJ; Sorensen, BK; Tasker, A; von Geldern, TW; Winn, M; Wu-Wong, JR	1
Adler, AL; Calzadilla, SV; Dayton, BD; Jae, HS; Marsh, KC; Novosad, EI; Opgenorth, TJ; von Geldern, TW; Wessale, JL; Winn, M; Wu-Wong, JR	1
Abassi, Z; Francis, B; Hoffman, A; Ovcharenko, E; Wessale, J; Winaver, J	1
Guimarães, CL; Rae, GA; Trentin, PG	1
Burke, SE; Cox, BF; Opgenorth, TJ; Preusser, LC; Reinhart, GA; Wegner, CD; Wessale, JL	1
Horio, T; Johnson, RJ; Kangawa, K; Kawano, Y; Suga, S; Yasui, N; Yoshihara, F	1
Gariepy, CE; Pollock, DM; Pollock, JS; Taylor, TA	1
Brink, AK; Nelson, JB; Pecher, S; Pflug, BR	1
Ghilardi, JR; Lindsay, TH; Luger, NM; Mantyh, PW; Peters, CM; Pomonis, JD; Sevcik, MA	1
Eshiro, K; Matsumura, Y; Nishida, M; Okada, Y; Takaoka, M	1
Chancellor, MB; de Groat, WC; Igawa, Y; Kamo, I; Nelson, JB; Nishizawa, O; Ogawa, T; Pflug, BR; Seki, S; Yoshimura, N	1
Akiyoshi, K; Eshiro, K; Hayashi, T; Ieshima, M; Kitaura, Y; Matsumura, Y; Mori, T; Nishida, M; Okada, Y; Takaoka, M; Yoshikawa, J; Yoshiyama, M	1
Fujita, M; Gariepy, CE; Kanazawa, M; Matsumoto, N; Matsumura, Y; Takaoka, M; Yamamoto, S; Yanagisawa, M	1
Ayach, B; Battistini, B; Blouin, A; Cernacek, P; Jeng, AY; Opgenorth, T; Tsang, J; Verreault, M; Wessale, J	1
Fujita, M; Kanazawa, M; Matsumoto, N; Matsumura, Y; Takaoka, M; Yamamoto, S	1
Abassi, Z; Francis, B; Hoffman, A; Karram, T; Winaver, J	1
D'Orléans-Juste, P; Fecteau, MH; Honoré, JC; Wessale, JL	1
Bkaily, G; Brochu, I; D'Orleans-Juste, P; Fecteau, MH; Honoré, JC; Labonté, J	1
Cook, AK; Imig, JD; Inscho, EW; Pollock, DM	1
Banfor, PN; Cox, BF; Fryer, RM; Opgenorth, TJ; Rakestraw, PA; Reinhart, GA	1
Chichorro, JG; Rae, GA; Souza, GE; Zampronio, AR	1
Al-Khoury, J; Bkaily, G; Chahine, M; D'Orléans-Juste, P; Jacques, D	1
Caron, A; Dupuis, J; Sauvageau, S; Thorin, E	1
Abassi, Z; Bishara, B; Hoffman, A; Karram, T; Khatib, S; Winaver, J	1
Elgebaly, MM; Ergul, A; Harris, AK; Li, W; Sachidanandam, K	1
Elgebaly, MM; Ergul, A; Harris, AK; Hutchinson, JR; Mezzetti, EM; Portik-Dobos, V; Sachidanandam, K	1
Bkaily, G; Carrier, E; D'Orleans-Juste, P; Fecteau, MH; Honoré, JC; Tirapelli, CR	1
Cabrini, DA; Chichorro, JG; Franco, CR; Rae, GA; Zampronio, AR	1
Feng, HQ; Rockey, DC; Weymouth, ND	1
Ariaans, MP; Brookes, ZL; Brown, NJ; Kaufman, S; Mansart, A; Reilly, CS; Ross, JJ; Ruff, LJ	1
Hamel, E; Ongali, B; Papadopoulos, P	1
Bento, AF; Chichorro, JG; Claudino, RF; Marcon, R; Rae, GA	1
Boesen, EI; Pollock, DM; Pollock, JS	1
Avedanian, L; Bkaily, G; D'Orleans-Juste, P; Jacques, D; Nader, M; Riopel, J	1
Boesen, EI; Pollock, DM	1
Ayajiki, K; Fukumoto, T; Geddawy, A; Imamura, T; Matsumura, Y; Ohkita, M; Okamura, T; Tawa, M; Yamashita, N	1
Chang, NC; Chung, TH; Lee, TM; Lin, SZ	1

Other Studies

43 other study(ies) available for atrasentan and a 192621

Article	Year
Pyrrolidine-3-carboxylic acids as endothelin antagonists. 4. Side chain conformational restriction leads to ET(B) selectivity. Journal of medicinal chemistry, 1999, Sep-09, Volume: 42, Issue:18 Topics: Acetanilides; Animals; Atrasentan; Blood Pressure; Cell Line; Endothelin Receptor Antagonists; Endothelin-1; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B	1999
ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain. European journal of pharmacology, 2000, Jan-24, Volume: 388, Issue:1 Topics: Analgesics, Non-Narcotic; Animals; Atrasentan; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Endothelin Receptor Antagonists; Humans; Male; Pain; Pain Measurement; Physical Stimulation; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Stereoisomerism; Vasoconstrictor Agents	2000
Evidence for vasoconstriction mediated by the endothelin-B receptor in domestic swine. Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:6 Topics: Angiotensin II; Animals; Animals, Domestic; Atrasentan; Blood Pressure; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Female; Femoral Artery; Protein Precursors; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Swine; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms	2000
Selective antagonism of the ETA receptor, but not the ETB receptor, is protective against ischemic acute renal failure in rats. Japanese journal of pharmacology, 2000, Volume: 82, Issue:4 Topics: Acute Kidney Injury; Animals; Atrasentan; Endothelin Receptor Antagonists; Endothelin-1; Ischemia; Kidney; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Reperfusion Injury	2000
Selective endothelin-A versus combined endothelin-A/endothelin-B receptor blockade in rat chronic heart failure. Circulation, 2000, Aug-01, Volume: 102, Issue:5 Topics: Animals; Atrasentan; Blood Pressure; Collagen; Endothelin Receptor Antagonists; Endothelin-1; Heart Failure; Hemodynamics; Myocardial Infarction; Myocardium; Pyrrolidines; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Ventricular Function, Left	2000
Effects of endothelin receptor antagonists on the plasma immunoreactive endothelin-1 level. Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:5 Suppl 1 Topics: Animals; Atrasentan; Endothelin Receptor Antagonists; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B	2000
Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: in vitro studies. Clinical science (London, England : 1979), 2002, Volume: 103 Suppl 48 Topics: Animals; Arachidonic Acid; Atrasentan; Binding, Competitive; Cell Line; CHO Cells; Cricetinae; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hydrolysis; Iodine Radioisotopes; Phosphatidylinositols; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Transfection; Vasodilator Agents	2002
Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: ex vivo and in vivo studies. Clinical science (London, England : 1979), 2002, Volume: 103 Suppl 48 Topics: Analysis of Variance; Animals; Aorta; Atrasentan; Dogs; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Macaca fascicularis; Male; Muscle, Smooth, Vascular; Pyrrolidines; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Vasoconstrictor Agents; Vasodilator Agents; Viper Venoms	2002
Effects of endothelin receptors ET(A) and ET(B) blockade on renal haemodynamics in normal rats and in rats with experimental congestive heart failure. Clinical science (London, England : 1979), 2002, Volume: 103 Suppl 48 Topics: Animals; Atrasentan; Blood Pressure; Endothelin Receptor Antagonists; Endothelin-1; Glomerular Filtration Rate; Heart Failure; Kidney; Male; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Renal Circulation; Vascular Resistance	2002
Endothelin ET(B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice. Clinical science (London, England : 1979), 2002, Volume: 103 Suppl 48 Topics: Acute Disease; Analysis of Variance; Animals; Atrasentan; Bosentan; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Evans Blue; Lung; Male; Mice; Mice, Inbred Strains; Neutrophil Infiltration; Oleic Acid; Pyrimidines; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Respiratory Distress Syndrome; Sulfonamides	2002
Hypertension induced by blockade of ET(B) receptors in conscious nonhuman primates: role of ET(A) receptors. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:4 Topics: Animals; Antineoplastic Agents; Atrasentan; Blood Pressure; Consciousness; Endothelin Receptor Antagonists; Endothelin-1; Heart Rate; Homeostasis; Hypertension; Macaca fascicularis; Male; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Telemetry	2002
Endothelin a receptor blockade and endothelin B receptor blockade improve hypokalemic nephropathy by different mechanisms. Journal of the American Society of Nephrology : JASN, 2003, Volume: 14, Issue:2 Topics: Albuminuria; Animals; Atrasentan; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Hypertrophy; Hypokalemia; Kidney; Kidney Diseases; Kidney Tubules; Male; Potassium; Proteinuria; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B	2003
Unique endothelin receptor binding in kidneys of ETB receptor deficient rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 284, Issue:3 Topics: Animals; Atrasentan; Binding, Competitive; Down-Regulation; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Gene Deletion; Kidney; Kidney Cortex; Kidney Medulla; Male; Pyrrolidines; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin	2003
Endothelin A receptor blockade does not alter PSA secretion in prostate cancer cell lines. The Prostate, 2004, Aug-01, Volume: 60, Issue:3 Topics: Atrasentan; Endothelin A Receptor Antagonists; Endothelin-1; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Pyrrolidines; Receptor, Endothelin A; Tumor Cells, Cultured	2004
Endothelin and the tumorigenic component of bone cancer pain. Neuroscience, 2004, Volume: 126, Issue:4 Topics: Analysis of Variance; Animals; Atrasentan; Behavior, Animal; Bone Neoplasms; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dynorphins; Endothelin Receptor Antagonists; Endothelin-1; Ganglia, Spinal; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Pain; Pain Measurement; Pyrrolidines; Receptors, Endothelin; Sarcoma; Sciatic Nerve; Time Factors	2004
Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension. Journal of cardiovascular pharmacology, 2004, Volume: 44, Issue:2 Topics: Administration, Oral; Animals; Atrasentan; Blood Pressure; Body Mass Index; Body Weight; Cardiomegaly; Drug Administration Schedule; Drug Therapy, Combination; Heart; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Subcutaneous; Intubation, Gastrointestinal; Lung; Male; Monocrotaline; Organ Size; Pulmonary Artery; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Time Factors; Tunica Media; Ventricular Pressure	2004
Differential roles of peripheral and spinal endothelin receptors in the micturition reflex in rats. The Journal of urology, 2004, Volume: 172, Issue:4 Pt 1 Topics: Afferent Pathways; Animals; Atrasentan; Capsaicin; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Female; Injections, Spinal; Muscle Hypertonia; Naloxone; Nerve Fibers, Unmyelinated; Peripheral Nerves; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Receptors, Opioid; Reflex; Spinal Cord; Urinary Bladder; Urination; Urodynamics	2004
Selective endothelin ET(B) receptor antagonist improves left ventricular function but exaggerates degeneration of cardiomyocytes in J2N-k hamsters. Circulation journal : official journal of the Japanese Circulation Society, 2005, Volume: 69, Issue:1 Topics: Animals; Atrasentan; Cardiomyopathy, Dilated; Cricetinae; Disease Models, Animal; Endothelin B Receptor Antagonists; Heart; Heart Function Tests; Male; Muscle Cells; Myocardium; Pyrrolidines; Ventricular Function, Left	2005
Different contributions of endothelin-A and endothelin-B receptors in postischemic cardiac dysfunction and norepinephrine overflow in rat hearts. Circulation, 2005, Jan-25, Volume: 111, Issue:3 Topics: Amiloride; Animals; Animals, Genetically Modified; Atrasentan; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Gene Deletion; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Norepinephrine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Regional Blood Flow; Ventricular Pressure	2005
Role of the endothelin system in secondary pulmonary hypertension related to air embolism: lessons learned from testing four classes of endothelin blockers in a rat model. Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1 Topics: Acute Disease; Animals; Aspartic Acid Endopeptidases; Atrasentan; Benzofurans; Cardiovascular Agents; Disease Models, Animal; Embolism, Air; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-Converting Enzymes; Endothelins; Hemodynamics; Hypertension, Pulmonary; Male; Metalloendopeptidases; Organophosphonates; Protease Inhibitors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Time Factors; Ventricular Dysfunction, Right	2004
Effects of ET(A) and ET(B) receptor blockade on post-ischemic cardiac dysfunction and norepinephrine overflow in isolated rat hearts. Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1 Topics: Animals; Atrasentan; Cardiovascular Agents; Coronary Circulation; Drug Therapy, Combination; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Myocardium; Norepinephrine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Sympathetic Nervous System; Time Factors; Up-Regulation; Ventricular Dysfunction, Left; Ventricular Pressure	2004
Renal and systemic effects of chronic blockade of ET(A) or ET(B) receptors in normal rats and animals with experimental heart failure. Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1 Topics: Animals; Atrasentan; Blood Pressure; Cardiomegaly; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Heart Failure; Hemodynamics; Infusion Pumps, Implantable; Kidney; Male; Natriuresis; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Time Factors; Vasoconstriction; Vasodilation	2004
Effects of selective and non-selective endothelin receptor blockade on ET-1-induced pressor response in the hamster. Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1 Topics: Animals; Atrasentan; Blood Pressure; Cricetinae; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelins; Injections, Intravenous; Male; Mesocricetus; Peptide Fragments; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B	2004
Concomitant antagonism of endothelial and vascular smooth muscle cell ETB receptors for endothelin induces hypertension in the hamster. American journal of physiology. Heart and circulatory physiology, 2005, Volume: 289, Issue:3 Topics: Anesthesia; Animals; Atrasentan; Blood Pressure; Consciousness; Cricetinae; Dose-Response Relationship, Drug; Endothelin B Receptor Antagonists; Endothelin-1; Endothelins; Endothelium, Vascular; Hypertension; Male; Mesocricetus; Muscle, Smooth, Vascular; Peptide Fragments; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B	2005
ETA and ETB receptors differentially modulate afferent and efferent arteriolar responses to endothelin. British journal of pharmacology, 2005, Volume: 146, Issue:7 Topics: Animals; Arterioles; Atrasentan; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelins; Male; Peptide Fragments; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Vasoconstriction; Viper Venoms	2005
Blood pressure regulation by ETA and ETB receptors in conscious, telemetry-instrumented mice and role of ETA in hypertension produced by selective ETB blockade. American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:6 Topics: Animals; Atrasentan; Blood Pressure; Dose-Response Relationship, Drug; Endothelin B Receptor Antagonists; Heart Rate; Hypertension; Mice; Mice, Inbred C57BL; Pyrrolidines; Receptor, Endothelin A; Telemetry	2006
Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs. Pain, 2006, Volume: 123, Issue:1-2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atrasentan; Bosentan; Carrageenan; Celecoxib; Cold Temperature; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelin-1; Endothelins; Grooming; Hyperalgesia; Indomethacin; Male; Maxillary Nerve; Nerve Compression Syndromes; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Pyrazoles; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Trigeminal Neuralgia	2006
ETB receptor dependent alteration in aortic responses to ET-1 in the cardiomyopathic hamster. Canadian journal of physiology and pharmacology, 2006, Volume: 84, Issue:7 Topics: Animals; Aorta; Atrasentan; Cardiomyopathy, Dilated; Cricetinae; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelium, Vascular; In Vitro Techniques; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Vasoconstriction	2006
Endothelin-1-induced pulmonary vasoreactivity is regulated by ET(A) and ET(B) receptor interactions. Journal of vascular research, 2007, Volume: 44, Issue:5 Topics: Animals; Atrasentan; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; In Vitro Techniques; Isometric Contraction; Lung; Male; Perfusion; Pressure; Pulmonary Artery; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Vascular Resistance; Vasoconstriction; Vasodilation; Viper Venoms	2007
Adverse effects of pneumoperitoneum on renal function: involvement of the endothelin and nitric oxide systems. American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:3 Topics: Animals; Atrasentan; Blood Pressure; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelins; Enzyme Inhibitors; Glomerular Filtration Rate; Kidney; Kidney Function Tests; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitroglycerin; Pneumoperitoneum, Artificial; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Renal Circulation; Renal Plasma Flow; Vasodilator Agents	2008
Effect of chronic endothelin receptor antagonism on cerebrovascular function in type 2 diabetes. American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:4 Topics: Acetylcholine; Animals; Atrasentan; Basilar Artery; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Male; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Viper Venoms	2008
Effect of chronic and selective endothelin receptor antagonism on microvascular function in type 2 diabetes. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:6 Topics: Acetylcholine; Animals; Atrasentan; Cardiovascular Agents; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Male; Mesenteric Arteries; Microcirculation; Myography; Peptides, Cyclic; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Viper Venoms	2008
Nonselective ETA/ETB-receptor blockade increases systemic blood pressure of Bio 14.6 cardiomyopathic hamsters. Canadian journal of physiology and pharmacology, 2008, Volume: 86, Issue:6 Topics: Animals; Atrasentan; Blood Pressure; Cardiomyopathies; Cricetinae; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Heart Failure; Hemodynamics; Mesocricetus; Nitrates; Nitrites; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Ventricular Function, Left	2008
Mechanisms operated by endothelin ETA and ETB receptors in the trigeminal ganglion contribute to orofacial thermal hyperalgesia induced by infraorbital nerve constriction in rats. Neuropeptides, 2009, Volume: 43, Issue:2 Topics: Animals; Atrasentan; Constriction, Pathologic; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Face; Hyperalgesia; Maxillary Nerve; Pyrrolidines; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Trigeminal Ganglion	2009
Endothelin antagonism in portal hypertensive mice: implications for endothelin receptor-specific signaling in liver disease. American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:1 Topics: Animals; Atrasentan; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelins; Hypertension, Portal; Infusions, Intravenous; Liver; Liver Circulation; Liver Cirrhosis, Experimental; Male; Mice; Mice, Inbred C57BL; Portal Pressure; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Time Factors; Vasoconstriction; Vasodilation	2009
Constriction of rat extra-splenic veins to lipopolysaccharide involves endothelin-1. Naunyn-Schmiedeberg's archives of pharmacology, 2010, Volume: 381, Issue:6 Topics: Animals; Atrasentan; Bosentan; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Hypovolemia; Lipopolysaccharides; Male; Mesentery; Myography; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Spleen; Sulfonamides; Vasoconstriction	2010
Selective in vivo antagonism of endothelin receptors in transforming growth factor-beta1 transgenic mice that mimic the vascular pathology of Alzheimer's disease. Canadian journal of physiology and pharmacology, 2010, Volume: 88, Issue:6 Topics: Aging; Alzheimer Disease; Animals; Atrasentan; Blood Vessels; Brain; Cerebral Arteries; Cerebrovascular Circulation; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Female; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Nitroarginine; Pyrrolidines; Transforming Growth Factor beta1; Vasoconstriction; Vasodilation; Vasodilator Agents; Vibrissae	2010
Endothelins implicated in referred mechanical hyperalgesia associated with colitis induced by TNBS in mice. Canadian journal of physiology and pharmacology, 2010, Volume: 88, Issue:6 Topics: Abdominal Pain; Animals; Atrasentan; Colitis; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelins; Foot; Hindlimb; Hyperalgesia; Male; Mice; Mice, Inbred BALB C; Morphine; Pain, Referred; Pyrrolidines; Touch; Trinitrobenzenesulfonic Acid	2010
Contrasting effects of intervention with ETA and ETB receptor antagonists in hypertension induced by angiotensin II and high-salt diet. Canadian journal of physiology and pharmacology, 2010, Volume: 88, Issue:8 Topics: Acute Kidney Injury; Angiotensin II; Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Hypertension; Male; Nitrates; Nitrites; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Treatment Outcome	2010
ETA receptors are present in human aortic vascular endothelial cells and modulate intracellular calcium. Canadian journal of physiology and pharmacology, 2010, Volume: 88, Issue:8 Topics: Adolescent; Adult; Aorta; Atrasentan; Calcium Signaling; Cell Membrane; Cell Nucleus; Cytosol; Egtazic Acid; Endothelial Cells; Endothelin B Receptor Antagonists; Endothelin-1; Humans; Middle Aged; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Young Adult	2010
Cooperative role of ETA and ETB receptors in mediating the diuretic response to intramedullary hyperosmotic NaCl infusion. American journal of physiology. Renal physiology, 2010, Volume: 299, Issue:6 Topics: Animals; Atrasentan; Diuresis; Hypertonic Solutions; Kidney Medulla; Mannitol; Natriuresis; Osmolar Concentration; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Saline Solution, Hypertonic; Sodium Chloride	2010
Effects of exogenous big endothelin-1 on postischemic cardiac dysfunction and norepinephrine overflow in rat hearts. Hypertension research : official journal of the Japanese Society of Hypertension, 2011, Volume: 34, Issue:2 Topics: Animals; Aspartic Acid Endopeptidases; Atrasentan; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Male; Metalloendopeptidases; Myocardial Reperfusion Injury; Norepinephrine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfonylurea Compounds; Ventricular Dysfunction, Left	2011
Endothelin receptor blockade ameliorates renal injury by inhibition of RhoA/Rho-kinase signalling in deoxycorticosterone acetate-salt hypertensive rats. Journal of hypertension, 2014, Volume: 32, Issue:4 Topics: Animals; Atrasentan; Blood Pressure; Desoxycorticosterone Acetate; Endothelin Receptor Antagonists; Endothelin-1; Fibrosis; Gene Expression Regulation; Hypertension; Kidney; Male; Proteinuria; Pyrrolidines; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Sodium Chloride, Dietary	2014