atrasentan has been researched along with a 192621 in 43 studies
Studies (atrasentan) | Trials (atrasentan) | Recent Studies (post-2010) (atrasentan) | Studies (a 192621) | Trials (a 192621) | Recent Studies (post-2010) (a 192621) |
---|---|---|---|---|---|
358 | 41 | 108 | 84 | 0 | 8 |
Protein | Taxonomy | atrasentan (IC50) | a 192621 (IC50) |
---|---|---|---|
Endothelin receptor type B | Homo sapiens (human) | 0.0051 | |
Endothelin-1 receptor | Homo sapiens (human) | 9.05 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (2.33) | 18.2507 |
2000's | 34 (79.07) | 29.6817 |
2010's | 8 (18.60) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Adler, A; Chiou, WJ; Dixon, DB; Marsh, KC; Nguyen, B; Opgenorth, TJ; Sorensen, BK; Szczepankiewicz, BG; Tasker, AS; von Geldern, TW; Wang, L; Wessale, JL; Winn, M | 1 |
Calzadilla, SV; Dayton, BD; Jarvis, MF; Kowaluk, EA; Lynch, JJ; Opgenorth, TJ; Padley, RJ; Wessale, JL; Zhu, CZ | 1 |
Burke, SE; Cox, BF; Ford, TT; Fu, KI; Lubbers, NL; Nelson, RA; Padley, RJ; Wegner, CD | 1 |
Kobayashi, Y; Kohnou, K; Kuro, T; Matsumura, Y; Opgenorth, TJ; Takaoka, M; Wessale, JL | 1 |
Boujedaini, H; Derumeaux, G; Henry, JP; Mulder, P; Opgenorth, T; Renet, S; Richard, V; Thuillez, C; Wessale, J | 1 |
Adler, AL; Calzadilla, SV; Dixon, DB; Opgenorth, TJ; Padley, RJ; Wessale, JL; Wu-Wong, JR | 1 |
Chiou, WJ; Dixon, DB; Jae, HS; Liu, G; Opgenorth, TJ; Sorensen, BK; Tasker, A; von Geldern, TW; Winn, M; Wu-Wong, JR | 1 |
Adler, AL; Calzadilla, SV; Dayton, BD; Jae, HS; Marsh, KC; Novosad, EI; Opgenorth, TJ; von Geldern, TW; Wessale, JL; Winn, M; Wu-Wong, JR | 1 |
Abassi, Z; Francis, B; Hoffman, A; Ovcharenko, E; Wessale, J; Winaver, J | 1 |
Guimarães, CL; Rae, GA; Trentin, PG | 1 |
Burke, SE; Cox, BF; Opgenorth, TJ; Preusser, LC; Reinhart, GA; Wegner, CD; Wessale, JL | 1 |
Horio, T; Johnson, RJ; Kangawa, K; Kawano, Y; Suga, S; Yasui, N; Yoshihara, F | 1 |
Gariepy, CE; Pollock, DM; Pollock, JS; Taylor, TA | 1 |
Brink, AK; Nelson, JB; Pecher, S; Pflug, BR | 1 |
Ghilardi, JR; Lindsay, TH; Luger, NM; Mantyh, PW; Peters, CM; Pomonis, JD; Sevcik, MA | 1 |
Eshiro, K; Matsumura, Y; Nishida, M; Okada, Y; Takaoka, M | 1 |
Chancellor, MB; de Groat, WC; Igawa, Y; Kamo, I; Nelson, JB; Nishizawa, O; Ogawa, T; Pflug, BR; Seki, S; Yoshimura, N | 1 |
Akiyoshi, K; Eshiro, K; Hayashi, T; Ieshima, M; Kitaura, Y; Matsumura, Y; Mori, T; Nishida, M; Okada, Y; Takaoka, M; Yoshikawa, J; Yoshiyama, M | 1 |
Fujita, M; Gariepy, CE; Kanazawa, M; Matsumoto, N; Matsumura, Y; Takaoka, M; Yamamoto, S; Yanagisawa, M | 1 |
Ayach, B; Battistini, B; Blouin, A; Cernacek, P; Jeng, AY; Opgenorth, T; Tsang, J; Verreault, M; Wessale, J | 1 |
Fujita, M; Kanazawa, M; Matsumoto, N; Matsumura, Y; Takaoka, M; Yamamoto, S | 1 |
Abassi, Z; Francis, B; Hoffman, A; Karram, T; Winaver, J | 1 |
D'Orléans-Juste, P; Fecteau, MH; Honoré, JC; Wessale, JL | 1 |
Bkaily, G; Brochu, I; D'Orleans-Juste, P; Fecteau, MH; Honoré, JC; Labonté, J | 1 |
Cook, AK; Imig, JD; Inscho, EW; Pollock, DM | 1 |
Banfor, PN; Cox, BF; Fryer, RM; Opgenorth, TJ; Rakestraw, PA; Reinhart, GA | 1 |
Chichorro, JG; Rae, GA; Souza, GE; Zampronio, AR | 1 |
Al-Khoury, J; Bkaily, G; Chahine, M; D'Orléans-Juste, P; Jacques, D | 1 |
Caron, A; Dupuis, J; Sauvageau, S; Thorin, E | 1 |
Abassi, Z; Bishara, B; Hoffman, A; Karram, T; Khatib, S; Winaver, J | 1 |
Elgebaly, MM; Ergul, A; Harris, AK; Li, W; Sachidanandam, K | 1 |
Elgebaly, MM; Ergul, A; Harris, AK; Hutchinson, JR; Mezzetti, EM; Portik-Dobos, V; Sachidanandam, K | 1 |
Bkaily, G; Carrier, E; D'Orleans-Juste, P; Fecteau, MH; Honoré, JC; Tirapelli, CR | 1 |
Cabrini, DA; Chichorro, JG; Franco, CR; Rae, GA; Zampronio, AR | 1 |
Feng, HQ; Rockey, DC; Weymouth, ND | 1 |
Ariaans, MP; Brookes, ZL; Brown, NJ; Kaufman, S; Mansart, A; Reilly, CS; Ross, JJ; Ruff, LJ | 1 |
Hamel, E; Ongali, B; Papadopoulos, P | 1 |
Bento, AF; Chichorro, JG; Claudino, RF; Marcon, R; Rae, GA | 1 |
Boesen, EI; Pollock, DM; Pollock, JS | 1 |
Avedanian, L; Bkaily, G; D'Orleans-Juste, P; Jacques, D; Nader, M; Riopel, J | 1 |
Boesen, EI; Pollock, DM | 1 |
Ayajiki, K; Fukumoto, T; Geddawy, A; Imamura, T; Matsumura, Y; Ohkita, M; Okamura, T; Tawa, M; Yamashita, N | 1 |
Chang, NC; Chung, TH; Lee, TM; Lin, SZ | 1 |
43 other study(ies) available for atrasentan and a 192621
Article | Year |
---|---|
Pyrrolidine-3-carboxylic acids as endothelin antagonists. 4. Side chain conformational restriction leads to ET(B) selectivity.
Topics: Acetanilides; Animals; Atrasentan; Blood Pressure; Cell Line; Endothelin Receptor Antagonists; Endothelin-1; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B | 1999 |
ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain.
Topics: Analgesics, Non-Narcotic; Animals; Atrasentan; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Endothelin Receptor Antagonists; Humans; Male; Pain; Pain Measurement; Physical Stimulation; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Stereoisomerism; Vasoconstrictor Agents | 2000 |
Evidence for vasoconstriction mediated by the endothelin-B receptor in domestic swine.
Topics: Angiotensin II; Animals; Animals, Domestic; Atrasentan; Blood Pressure; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Female; Femoral Artery; Protein Precursors; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Swine; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Viper Venoms | 2000 |
Selective antagonism of the ETA receptor, but not the ETB receptor, is protective against ischemic acute renal failure in rats.
Topics: Acute Kidney Injury; Animals; Atrasentan; Endothelin Receptor Antagonists; Endothelin-1; Ischemia; Kidney; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Reperfusion Injury | 2000 |
Selective endothelin-A versus combined endothelin-A/endothelin-B receptor blockade in rat chronic heart failure.
Topics: Animals; Atrasentan; Blood Pressure; Collagen; Endothelin Receptor Antagonists; Endothelin-1; Heart Failure; Hemodynamics; Myocardial Infarction; Myocardium; Pyrrolidines; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Ventricular Function, Left | 2000 |
Effects of endothelin receptor antagonists on the plasma immunoreactive endothelin-1 level.
Topics: Animals; Atrasentan; Endothelin Receptor Antagonists; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B | 2000 |
Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: in vitro studies.
Topics: Animals; Arachidonic Acid; Atrasentan; Binding, Competitive; Cell Line; CHO Cells; Cricetinae; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hydrolysis; Iodine Radioisotopes; Phosphatidylinositols; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Transfection; Vasodilator Agents | 2002 |
Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: ex vivo and in vivo studies.
Topics: Analysis of Variance; Animals; Aorta; Atrasentan; Dogs; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Macaca fascicularis; Male; Muscle, Smooth, Vascular; Pyrrolidines; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Vasoconstrictor Agents; Vasodilator Agents; Viper Venoms | 2002 |
Effects of endothelin receptors ET(A) and ET(B) blockade on renal haemodynamics in normal rats and in rats with experimental congestive heart failure.
Topics: Animals; Atrasentan; Blood Pressure; Endothelin Receptor Antagonists; Endothelin-1; Glomerular Filtration Rate; Heart Failure; Kidney; Male; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Renal Circulation; Vascular Resistance | 2002 |
Endothelin ET(B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice.
Topics: Acute Disease; Analysis of Variance; Animals; Atrasentan; Bosentan; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Evans Blue; Lung; Male; Mice; Mice, Inbred Strains; Neutrophil Infiltration; Oleic Acid; Pyrimidines; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Respiratory Distress Syndrome; Sulfonamides | 2002 |
Hypertension induced by blockade of ET(B) receptors in conscious nonhuman primates: role of ET(A) receptors.
Topics: Animals; Antineoplastic Agents; Atrasentan; Blood Pressure; Consciousness; Endothelin Receptor Antagonists; Endothelin-1; Heart Rate; Homeostasis; Hypertension; Macaca fascicularis; Male; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Telemetry | 2002 |
Endothelin a receptor blockade and endothelin B receptor blockade improve hypokalemic nephropathy by different mechanisms.
Topics: Albuminuria; Animals; Atrasentan; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; Hypertrophy; Hypokalemia; Kidney; Kidney Diseases; Kidney Tubules; Male; Potassium; Proteinuria; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B | 2003 |
Unique endothelin receptor binding in kidneys of ETB receptor deficient rats.
Topics: Animals; Atrasentan; Binding, Competitive; Down-Regulation; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Gene Deletion; Kidney; Kidney Cortex; Kidney Medulla; Male; Pyrrolidines; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin | 2003 |
Endothelin A receptor blockade does not alter PSA secretion in prostate cancer cell lines.
Topics: Atrasentan; Endothelin A Receptor Antagonists; Endothelin-1; Humans; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Pyrrolidines; Receptor, Endothelin A; Tumor Cells, Cultured | 2004 |
Endothelin and the tumorigenic component of bone cancer pain.
Topics: Analysis of Variance; Animals; Atrasentan; Behavior, Animal; Bone Neoplasms; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dynorphins; Endothelin Receptor Antagonists; Endothelin-1; Ganglia, Spinal; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Pain; Pain Measurement; Pyrrolidines; Receptors, Endothelin; Sarcoma; Sciatic Nerve; Time Factors | 2004 |
Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension.
Topics: Administration, Oral; Animals; Atrasentan; Blood Pressure; Body Mass Index; Body Weight; Cardiomegaly; Drug Administration Schedule; Drug Therapy, Combination; Heart; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Injections, Subcutaneous; Intubation, Gastrointestinal; Lung; Male; Monocrotaline; Organ Size; Pulmonary Artery; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Time Factors; Tunica Media; Ventricular Pressure | 2004 |
Differential roles of peripheral and spinal endothelin receptors in the micturition reflex in rats.
Topics: Afferent Pathways; Animals; Atrasentan; Capsaicin; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Female; Injections, Spinal; Muscle Hypertonia; Naloxone; Nerve Fibers, Unmyelinated; Peripheral Nerves; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Receptors, Opioid; Reflex; Spinal Cord; Urinary Bladder; Urination; Urodynamics | 2004 |
Selective endothelin ET(B) receptor antagonist improves left ventricular function but exaggerates degeneration of cardiomyocytes in J2N-k hamsters.
Topics: Animals; Atrasentan; Cardiomyopathy, Dilated; Cricetinae; Disease Models, Animal; Endothelin B Receptor Antagonists; Heart; Heart Function Tests; Male; Muscle Cells; Myocardium; Pyrrolidines; Ventricular Function, Left | 2005 |
Different contributions of endothelin-A and endothelin-B receptors in postischemic cardiac dysfunction and norepinephrine overflow in rat hearts.
Topics: Amiloride; Animals; Animals, Genetically Modified; Atrasentan; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Gene Deletion; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Norepinephrine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Regional Blood Flow; Ventricular Pressure | 2005 |
Role of the endothelin system in secondary pulmonary hypertension related to air embolism: lessons learned from testing four classes of endothelin blockers in a rat model.
Topics: Acute Disease; Animals; Aspartic Acid Endopeptidases; Atrasentan; Benzofurans; Cardiovascular Agents; Disease Models, Animal; Embolism, Air; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-Converting Enzymes; Endothelins; Hemodynamics; Hypertension, Pulmonary; Male; Metalloendopeptidases; Organophosphonates; Protease Inhibitors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Time Factors; Ventricular Dysfunction, Right | 2004 |
Effects of ET(A) and ET(B) receptor blockade on post-ischemic cardiac dysfunction and norepinephrine overflow in isolated rat hearts.
Topics: Animals; Atrasentan; Cardiovascular Agents; Coronary Circulation; Drug Therapy, Combination; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Myocardium; Norepinephrine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Sympathetic Nervous System; Time Factors; Up-Regulation; Ventricular Dysfunction, Left; Ventricular Pressure | 2004 |
Renal and systemic effects of chronic blockade of ET(A) or ET(B) receptors in normal rats and animals with experimental heart failure.
Topics: Animals; Atrasentan; Blood Pressure; Cardiomegaly; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Heart Failure; Hemodynamics; Infusion Pumps, Implantable; Kidney; Male; Natriuresis; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Time Factors; Vasoconstriction; Vasodilation | 2004 |
Effects of selective and non-selective endothelin receptor blockade on ET-1-induced pressor response in the hamster.
Topics: Animals; Atrasentan; Blood Pressure; Cricetinae; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelins; Injections, Intravenous; Male; Mesocricetus; Peptide Fragments; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B | 2004 |
Concomitant antagonism of endothelial and vascular smooth muscle cell ETB receptors for endothelin induces hypertension in the hamster.
Topics: Anesthesia; Animals; Atrasentan; Blood Pressure; Consciousness; Cricetinae; Dose-Response Relationship, Drug; Endothelin B Receptor Antagonists; Endothelin-1; Endothelins; Endothelium, Vascular; Hypertension; Male; Mesocricetus; Muscle, Smooth, Vascular; Peptide Fragments; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B | 2005 |
ETA and ETB receptors differentially modulate afferent and efferent arteriolar responses to endothelin.
Topics: Animals; Arterioles; Atrasentan; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelins; Male; Peptide Fragments; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Vasoconstriction; Viper Venoms | 2005 |
Blood pressure regulation by ETA and ETB receptors in conscious, telemetry-instrumented mice and role of ETA in hypertension produced by selective ETB blockade.
Topics: Animals; Atrasentan; Blood Pressure; Dose-Response Relationship, Drug; Endothelin B Receptor Antagonists; Heart Rate; Hypertension; Mice; Mice, Inbred C57BL; Pyrrolidines; Receptor, Endothelin A; Telemetry | 2006 |
Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atrasentan; Bosentan; Carrageenan; Celecoxib; Cold Temperature; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelin-1; Endothelins; Grooming; Hyperalgesia; Indomethacin; Male; Maxillary Nerve; Nerve Compression Syndromes; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Pyrazoles; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Trigeminal Neuralgia | 2006 |
ETB receptor dependent alteration in aortic responses to ET-1 in the cardiomyopathic hamster.
Topics: Animals; Aorta; Atrasentan; Cardiomyopathy, Dilated; Cricetinae; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelium, Vascular; In Vitro Techniques; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Vasoconstriction | 2006 |
Endothelin-1-induced pulmonary vasoreactivity is regulated by ET(A) and ET(B) receptor interactions.
Topics: Animals; Atrasentan; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; In Vitro Techniques; Isometric Contraction; Lung; Male; Perfusion; Pressure; Pulmonary Artery; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Vascular Resistance; Vasoconstriction; Vasodilation; Viper Venoms | 2007 |
Adverse effects of pneumoperitoneum on renal function: involvement of the endothelin and nitric oxide systems.
Topics: Animals; Atrasentan; Blood Pressure; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelins; Enzyme Inhibitors; Glomerular Filtration Rate; Kidney; Kidney Function Tests; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitroglycerin; Pneumoperitoneum, Artificial; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Renal Circulation; Renal Plasma Flow; Vasodilator Agents | 2008 |
Effect of chronic endothelin receptor antagonism on cerebrovascular function in type 2 diabetes.
Topics: Acetylcholine; Animals; Atrasentan; Basilar Artery; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Male; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Viper Venoms | 2008 |
Effect of chronic and selective endothelin receptor antagonism on microvascular function in type 2 diabetes.
Topics: Acetylcholine; Animals; Atrasentan; Cardiovascular Agents; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Male; Mesenteric Arteries; Microcirculation; Myography; Peptides, Cyclic; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Viper Venoms | 2008 |
Nonselective ETA/ETB-receptor blockade increases systemic blood pressure of Bio 14.6 cardiomyopathic hamsters.
Topics: Animals; Atrasentan; Blood Pressure; Cardiomyopathies; Cricetinae; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Heart Failure; Hemodynamics; Mesocricetus; Nitrates; Nitrites; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Ventricular Function, Left | 2008 |
Mechanisms operated by endothelin ETA and ETB receptors in the trigeminal ganglion contribute to orofacial thermal hyperalgesia induced by infraorbital nerve constriction in rats.
Topics: Animals; Atrasentan; Constriction, Pathologic; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Face; Hyperalgesia; Maxillary Nerve; Pyrrolidines; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Trigeminal Ganglion | 2009 |
Endothelin antagonism in portal hypertensive mice: implications for endothelin receptor-specific signaling in liver disease.
Topics: Animals; Atrasentan; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelins; Hypertension, Portal; Infusions, Intravenous; Liver; Liver Circulation; Liver Cirrhosis, Experimental; Male; Mice; Mice, Inbred C57BL; Portal Pressure; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Sulfonamides; Time Factors; Vasoconstriction; Vasodilation | 2009 |
Constriction of rat extra-splenic veins to lipopolysaccharide involves endothelin-1.
Topics: Animals; Atrasentan; Bosentan; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Hypovolemia; Lipopolysaccharides; Male; Mesentery; Myography; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; Spleen; Sulfonamides; Vasoconstriction | 2010 |
Selective in vivo antagonism of endothelin receptors in transforming growth factor-beta1 transgenic mice that mimic the vascular pathology of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Animals; Atrasentan; Blood Vessels; Brain; Cerebral Arteries; Cerebrovascular Circulation; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Female; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Nitroarginine; Pyrrolidines; Transforming Growth Factor beta1; Vasoconstriction; Vasodilation; Vasodilator Agents; Vibrissae | 2010 |
Endothelins implicated in referred mechanical hyperalgesia associated with colitis induced by TNBS in mice.
Topics: Abdominal Pain; Animals; Atrasentan; Colitis; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelins; Foot; Hindlimb; Hyperalgesia; Male; Mice; Mice, Inbred BALB C; Morphine; Pain, Referred; Pyrrolidines; Touch; Trinitrobenzenesulfonic Acid | 2010 |
Contrasting effects of intervention with ETA and ETB receptor antagonists in hypertension induced by angiotensin II and high-salt diet.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Hypertension; Male; Nitrates; Nitrites; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Treatment Outcome | 2010 |
ETA receptors are present in human aortic vascular endothelial cells and modulate intracellular calcium.
Topics: Adolescent; Adult; Aorta; Atrasentan; Calcium Signaling; Cell Membrane; Cell Nucleus; Cytosol; Egtazic Acid; Endothelial Cells; Endothelin B Receptor Antagonists; Endothelin-1; Humans; Middle Aged; Pyrrolidines; Receptor, Endothelin A; Receptor, Endothelin B; Young Adult | 2010 |
Cooperative role of ETA and ETB receptors in mediating the diuretic response to intramedullary hyperosmotic NaCl infusion.
Topics: Animals; Atrasentan; Diuresis; Hypertonic Solutions; Kidney Medulla; Mannitol; Natriuresis; Osmolar Concentration; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Saline Solution, Hypertonic; Sodium Chloride | 2010 |
Effects of exogenous big endothelin-1 on postischemic cardiac dysfunction and norepinephrine overflow in rat hearts.
Topics: Animals; Aspartic Acid Endopeptidases; Atrasentan; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Male; Metalloendopeptidases; Myocardial Reperfusion Injury; Norepinephrine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfonylurea Compounds; Ventricular Dysfunction, Left | 2011 |
Endothelin receptor blockade ameliorates renal injury by inhibition of RhoA/Rho-kinase signalling in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Animals; Atrasentan; Blood Pressure; Desoxycorticosterone Acetate; Endothelin Receptor Antagonists; Endothelin-1; Fibrosis; Gene Expression Regulation; Hypertension; Kidney; Male; Proteinuria; Pyrrolidines; Random Allocation; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Sodium Chloride, Dietary | 2014 |