Page last updated: 2024-08-23

atracurium and laudanosine

atracurium has been researched along with laudanosine in 76 studies

Research

Studies (76)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (30.26)	18.7374
1990's	38 (50.00)	18.2507
2000's	11 (14.47)	29.6817
2010's	4 (5.26)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Agoston, S; Eriksson, LI; Lennmarken, C; Vandenbrom, RH	1
Burgmann, H; Feigl, W; Reckendorfer, H; Schwarz, S; Sperlich, M; Spieckermann, PG; Tüchy, GL; Weindlmayr-Göttel, M	1
Banoub, M; Nigrovic, V	1
Hunter, JM; O'Sullivan, EP; Shearer, ES	1
Cyrenne, L; Gaudreault, P; Guay, J; Perreault, C; Varin, F	1
Beemer, GH; Bjorksten, AR; Crankshaw, DP	1
Fox, JL; Nigrovic, V	1
Bevan, DR; Donati, F; Ducharme, J; Gill, SS; Théorêt, Y; Varin, F	1
Fahy, LT; Hunter, JM; O'Sullivan, EP; Shearer, ES	1
Besner, JG; Ducharme, J; Théorêt, Y; Varin, F	1
Paquay, T; Senterre, J; Tabardel, Y	1
Eddleston, JM; Edwards, D; Gwinnutt, CL; Pollard, BJ	1
Benakis, A; Fathi, M; Le Coultre, C; Mentha, G; Morel, DR; Pittet, JF; Schopfer, C; Steinig, DA; Tassonyi, E	1
Canfell, PC; Fahey, MR; Hosobuchi, Y; Miller, RD; Taboada, T	1
Benakis, A; Schopfer, C	1
Anderton, JM; Harper, NJ; Thomas, AN	1
Besner, JG; Bevan, DR; Donati, F; Ducharme, J; Théorêt, Y; Varin, F	1
Agoston, S; Vandenbrom, RH; Wierda, JM	1
Hughes, R	1
Eddleston, JM; Edwards, D; Gwinnutt, CL; Harper, NJ; Pollard, BJ	1
Hunter, JM; Kent, AP; Parker, CJ	1
Kinjo, M; Nagashima, H; Vizi, ES	1
Charlton, AJ; Edwards, D; Harper, NJ; Wilson, AC	1
Beemer, GH; Bjorksten, AR; Crankshaw, DP; Dawson, PJ	1
Fry, K; Gallup, W; Nigrovic, V; Pandya, J	1
Hunter, JM; Parker, CJ	1
Standaert, FG	1
Canfell, C; Eger, EI; Fahey, MR; Fisher, DM; Miller, RD; Shi, WZ	1
Hunter, JM; Jones, JE; Parker, CJ	1
Hunter, JM; Peat, SJ; Potter, DR	1
Kidney, S; Nigrovic, V; Pandya, JB	1
Williams, SG	1
Arnold, RW; Dopson, T; Flynn, PJ; Simmonds, RJ; Weatherly, BC; Yate, PM	1
Boheimer, N; Dopson, TA; Simmonds, RJ; Ward, S; Weatherley, BC	1
Ward, S; Weatherley, BC	1
Nigrovic, V	1
Brandom, BW; Chakravorti, S; Cook, DR; Lai, A; Stiller, RL; Woelfel, SK	1
Canfell, C; Castagnoli, K; Fahey, MR; Fisher, DM; Hennis, PJ; Miller, RD; Rupp, SM; Sharma, M	2
Chakravorti, S; Cook, DR; Stiller, RL	1
Simmonds, RJ	1
Boyd, AH; Eastwood, NB; Hunter, JM; Parker, CJ	3
Miller, RD	1
Brown, A; Dahl, R; Ravitch, J; Welch, RM	1
Bickler, PE; Cardone, C; Szenohradszky, J; Yost, S	1
Hunter, JM	1
Bion, JF; Bowden, MI; Chow, B; Honisberger, L; Weatherley, BC	1
Burgmann, H; Reckendorfer, H; Schwarz, S; Sperlich, M; Spieckermann, PG; Tüchy, GL; Weindlmayr-Göttel, M	1
Becker, GL; Earl, RA; Landers, DF; Lawhead, RG; Matsumi, M; Peters, KR	1
Burgmann, H; Reckendorfer, H; Schwarz, S; Sperlich, M; Spieckermann, PG; Steltzer, H; Tüchy, E; Tüchy, GL; Weindlmayr-Göttel, M	1
Abalos, A; Belmont, MR; Kisor, DF; Lien, CA; Savarese, JJ; Schmith, VD	1
Cook, DR; De Wolf, AM; Freeman, JA; Kerls, S; Kisor, DF; Scott, VL; Smith, DA; Tullock, W	1
Banoub, M; Gaspari, J; Nigrovic, V	1
Cook, DR; Kisor, DF; Lien, CA; Ornstein, E; Schmith, VD; Wargin, WA	1
Hunter, JM; Parker, CJ; Smith, CE; van Miert, MM	1
Brusco, L; Grigore, AM; Koorn, R; Kuroda, M	1
Bertrand, D; Chiodini, FC; Fathi, M; Fuchs-Buder, T; Muller, D; Tassonyi, E	1
Kamper, EF; Siafaka, J; Stavridis, J	1
Audran, M; Bressolle, F; Farenc, C; Lefrant, JY; Mazerm, I	1
Audran, M; Bressolle, F; Farenc, C; Lefrant, JY	1
Kintz, P; Ludes, B; Tracqui, A	1
Bertrand, D; Charpantier, E; Chiodini, F; Fuchs-Buder, T; Muller, D; Tassonyi, E	1
Cerf, C; Dhonneur, G; Duvaldestin, P; Gillotin, C; Lagneau, F; Mantz, J	1
Bion, JF; Bowden, MI; Chow, B; Ho, E; Weatherley, BC	1
Fodale, V; Santamaria, LB	2
Cuvillon, P; De la Coussaye, JE; Eledjam, JJ; Farenc, C; Lefrant, JY; Muller, L; Ripart, J; Saissi, G	1
Bertrand, D; Chiodini, F; Fathi, M; Fuchs-Buder, T; Hughes, GJ; Muller, D; Tassonyi, E	1
Almarza, E; Ballesteros, S; Martínez, MA	1
Castagna, F; Favretto, D; Ferrara, SD; Montisci, M; Nalesso, A; Vogliardi, S	1
Chen, M; Kuang, Y; Yang, Y; Ye, L; Zhang, W	1
Cui, Y; Ding, M; Fan, Z; Gao, J; Zhang, X; Zuo, M	1
Abd El-Kawy, M; Abd El-Rahman, MK; Ma'mun, A	1
Aguilar, A; Andaluz, A; Cristòfol, C; García, F; Moll, X	1

Reviews

4 review(s) available for atracurium and laudanosine

Article	Year
Atracurium: an overview. British journal of anaesthesia, 1986, Volume: 58 Suppl 1 Topics: Animals; Atracurium; Dogs; Half-Life; Hemodynamics; Histamine Release; Humans; Isoquinolines; Neuromuscular Blocking Agents	1986
Review of atracurium by continuous i.v. infusion. British journal of anaesthesia, 1986, Volume: 58 Suppl 1 Topics: Animals; Atracurium; Humans; Infusions, Parenteral; Isoquinolines; Kinetics; Muscle Contraction; Neuromuscular Blocking Agents; Time Factors	1986
Atracurium and laudanosine pharmacokinetics in acute renal failure. Intensive care medicine, 1993, Volume: 19 Suppl 2 Topics: Acute Kidney Injury; Atracurium; Critical Illness; Humans; Isoquinolines; Metabolic Clearance Rate; Opium; Renal Dialysis	1993
Laudanosine, an atracurium and cisatracurium metabolite. European journal of anaesthesiology, 2002, Volume: 19, Issue:7 Topics: Atracurium; Humans; Isoquinolines; Neuromuscular Blocking Agents; Neuromuscular Nondepolarizing Agents	2002

Trials

9 trial(s) available for atracurium and laudanosine

Article	Year
Residual curarization in the neonate after caesarean section. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1991, Volume: 38, Issue:5 Topics: Anesthesia, Intravenous; Anesthesia, Obstetrical; Apgar Score; Atracurium; Cesarean Section; Double-Blind Method; Female; Fetal Blood; Fetus; Humans; Infant, Newborn; Isoquinolines; Maternal-Fetal Exchange; Muscle Tonus; Muscles; Opium; Pregnancy; Time Factors; Tubocurarine	1991
Production of laudanosine following infusion of atracurium in man and its effects on awakening. British journal of anaesthesia, 1989, Volume: 63, Issue:1 Topics: Anesthesia Recovery Period; Anesthesia, General; Atracurium; Brain; Humans; Isoquinolines; Middle Aged; Thiopental; Time Factors	1989
Atracurium infusions in patients with fulminant hepatic failure awaiting liver transplantation. Intensive care medicine, 1993, Volume: 19 Suppl 2 Topics: Adult; Atracurium; Drug Monitoring; Drug Therapy, Combination; Female; Hemofiltration; Hepatic Encephalopathy; Humans; Infusions, Intravenous; Isoquinolines; Liver Transplantation; Male; Metabolic Clearance Rate; Middle Aged; Narcotics; Respiration, Artificial; Survival Rate; Waiting Lists	1993
Pharmacokinetics of cisatracurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia. Anesthesiology, 1996, Volume: 84, Issue:2 Topics: Adult; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Atracurium; Female; Fentanyl; Humans; Isoquinolines; Male; Midazolam; Middle Aged; Neuromuscular Nondepolarizing Agents; Nitrous Oxide; Opium; Stereoisomerism; Thiopental	1996
Comparison of the pharmacodynamics and pharmacokinetics of an infusion of cis-atracurium (51W89) or atracurium in critically ill patients undergoing mechanical ventilation in an intensive therapy unit. British journal of anaesthesia, 1996, Volume: 76, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Atracurium; Critical Care; Critical Illness; Drug Administration Schedule; Female; Humans; Isoquinolines; Male; Middle Aged; Nerve Block; Neuromuscular Junction; Neuromuscular Nondepolarizing Agents; Respiration, Artificial; Stereoisomerism	1996
A comparison of the infusion pharmacokinetics and pharmacodynamics of cisatracurium, the 1R-cis 1'R-cis isomer of atracurium, with atracurium besylate in healthy patients. Anaesthesia, 1997, Volume: 52, Issue:9 Topics: Adult; Aged; Atracurium; Female; Humans; Isoquinolines; Male; Middle Aged; Models, Chemical; Neuromuscular Blockade; Neuromuscular Nondepolarizing Agents; Stereoisomerism; Time Factors	1997
Pharmacokinetic-pharmacodynamic modeling of atracurium in intensive care patients. Journal of clinical pharmacology, 2001, Volume: 41, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Atracurium; Critical Illness; Drug Administration Schedule; Humans; Infusions, Intravenous; Isoquinolines; Middle Aged; Models, Biological; Neuromuscular Nondepolarizing Agents; Respiration, Artificial; Respiratory Distress Syndrome	2001
Pharmacokinetics and dynamics of atracurium infusions after paediatric orthotopic liver transplantation. British journal of anaesthesia, 2000, Volume: 85, Issue:6 Topics: Atracurium; Child; Child, Preschool; Critical Care; Drug Administration Schedule; Female; Half-Life; Humans; Infant; Isoquinolines; Liver Transplantation; Male; Neuromuscular Blockade; Neuromuscular Nondepolarizing Agents; Postoperative Care	2000
Cerebrospinal fluid concentrations of atracurium, laudanosine and vecuronium following clinical subarachnoid hemorrhage. Acta anaesthesiologica Scandinavica, 2002, Volume: 46, Issue:10 Topics: Adolescent; Adult; Aged; Analysis of Variance; Atracurium; Central Nervous System Agents; Female; Humans; Intracranial Aneurysm; Isoquinolines; Male; Middle Aged; Neuromuscular Nondepolarizing Agents; Subarachnoid Hemorrhage; Time Factors; Vecuronium Bromide	2002

Other Studies

63 other study(ies) available for atracurium and laudanosine

Article	Year
Atracurium-induced neuromuscular block in the isolated arm. Acta anaesthesiologica Scandinavica, 1992, Volume: 36, Issue:7 Topics: Anesthesia Recovery Period; Anesthesia, Intravenous; Arm; Atracurium; Electric Stimulation; Electromyography; Female; Humans; Ischemia; Isoquinolines; Middle Aged; Muscles; Neuromuscular Junction; Perfusion; Skin Temperature; Synaptic Transmission; Thumb; Tourniquets	1992
Hepatotoxicity testing of atracurium and laudanosine in the isolated, perfused rat liver. British journal of anaesthesia, 1992, Volume: 69, Issue:3 Topics: Animals; Aspartate Aminotransferases; Atracurium; Bile; Isoquinolines; L-Lactate Dehydrogenase; Liver; Male; Organ Culture Techniques; Rats	1992
Pharmacokinetic modelling of a parent drug and its metabolite. Atracurium and laudanosine. Clinical pharmacokinetics, 1992, Volume: 22, Issue:5 Topics: Atracurium; Humans; Hydrogen-Ion Concentration; Isoquinolines; Metabolic Clearance Rate; Models, Biological; Temperature	1992
Clearance of atracurium and laudanosine in the urine and by continuous venovenous haemofiltration. British journal of anaesthesia, 1991, Volume: 67, Issue:5 Topics: Acute Kidney Injury; Adult; Aged; Atracurium; Female; Hemofiltration; Humans; Infusions, Intravenous; Isoquinolines; Male; Middle Aged	1991
Simple high-performance liquid chromatographic method for the analysis of the non-depolarizing neuromuscular blocking drugs in clinical anaesthesia. Journal of chromatography, 1990, Nov-30, Volume: 533 Topics: Alcuronium; Anesthesia; Atracurium; Chromatography, High Pressure Liquid; Humans; Isoquinolines; Neuromuscular Blocking Agents; Pancuronium; Silicon Dioxide; Tubocurarine; Vecuronium Bromide	1990
Atracurium decay and the formation of laudanosine in humans. Anesthesiology, 1991, Volume: 74, Issue:3 Topics: Atracurium; Computer Simulation; Humans; Isoquinolines; Liver Cirrhosis; Models, Biological; Software	1991
Pharmacokinetics and pharmacodynamics of atracurium obtained with arterial and venous blood samples. Clinical pharmacology and therapeutics, 1991, Volume: 49, Issue:5 Topics: Adolescent; Adult; Aged; Arteries; Atracurium; Bloodletting; Chromatography, High Pressure Liquid; Female; Forearm; Humans; Isoquinolines; Male; Middle Aged; Time Factors; Veins	1991
Transplacental distribution of atracurium, laudanosine and monoquaternary alcohol during elective caesarean section. British journal of anaesthesia, 1991, Volume: 66, Issue:5 Topics: Adolescent; Adult; Alcohols; Anesthesia, General; Anesthesia, Obstetrical; Atracurium; Cesarean Section; Female; Fetal Blood; Humans; Isoquinolines; Maternal-Fetal Exchange; Pregnancy; Time Factors; Umbilical Arteries; Umbilical Veins	1991
Determination of atracurium and laudanosine in human plasma by high-performance liquid chromatography. Journal of chromatography, 1990, Aug-03, Volume: 529, Issue:2 Topics: Atracurium; Chromatography, High Pressure Liquid; Half-Life; Humans; Indicators and Reagents; Isoquinolines; Spectrometry, Fluorescence	1990
Prolonged infusion of atracurium in an infant. Developmental pharmacology and therapeutics, 1990, Volume: 15, Issue:1 Topics: Atracurium; Chromatography, High Pressure Liquid; Drug Administration Schedule; Esophageal Atresia; Humans; Infant; Infusions, Intravenous; Isoquinolines; Postoperative Care	1990
Concentrations of atracurium and laudanosine in cerebrospinal fluid and plasma in three intensive care patients. British journal of anaesthesia, 1990, Volume: 65, Issue:6 Topics: Adult; Atracurium; Critical Care; Female; Humans; Isoquinolines; Male; Middle Aged; Opium	1990
Plasma concentrations of laudanosine, but not of atracurium, are increased during the anhepatic phase of orthotopic liver transplantation in pigs. Anesthesiology, 1990, Volume: 72, Issue:1 Topics: Animals; Atracurium; Isoquinolines; Liver; Liver Transplantation; Norepinephrine; Swine	1990
Cerebrospinal fluid concentrations of laudanosine after administration of atracurium. British journal of anaesthesia, 1990, Volume: 64, Issue:1 Topics: Anesthesia, General; Atracurium; Blood-Brain Barrier; Humans; Isoquinolines; Opium	1990
Simplified method for the determination of atracurium and laudanosine in pig plasma by high-performance liquid chromatography and fluorimetric detection. Journal of chromatography, 1990, Mar-16, Volume: 526, Issue:1 Topics: Animals; Atracurium; Calibration; Chromatography, High Pressure Liquid; Fluorometry; Isoquinolines; Swine	1990
Anaesthesia for the treatment of a giant cerebral aneurysm under hypothermic circulatory arrest. Anaesthesia, 1990, Volume: 45, Issue:5 Topics: Adult; Anesthesia, General; Atracurium; Female; Fentanyl; Heart Arrest, Induced; Humans; Hypothermia, Induced; Intracranial Aneurysm; Isoflurane; Isoquinolines; Thiopental	1990
Influence of extreme obesity on the body disposition and neuromuscular blocking effect of atracurium. Clinical pharmacology and therapeutics, 1990, Volume: 48, Issue:1 Topics: Adult; Atracurium; Female; Humans; Isoquinolines; Male; Middle Aged; Neuromuscular Blocking Agents; Obesity, Morbid	1990
Pharmacokinetics and neuromuscular blocking effects of atracurium besylate and two of its metabolites in patients with normal and impaired renal function. Clinical pharmacokinetics, 1990, Volume: 19, Issue:3 Topics: Adult; Aged; Alcohols; Anesthesia; Atracurium; Chromatography, High Pressure Liquid; Diazepam; Half-Life; Humans; Injections, Intravenous; Isoquinolines; Kidney Diseases; Middle Aged; Neuromuscular Blocking Agents; Premedication	1990
Concentrations of atracurium and laudanosine in cerebrospinal fluid and plasma during intracranial surgery. British journal of anaesthesia, 1989, Volume: 63, Issue:5 Topics: Adult; Aged; Atracurium; Humans; Intracranial Aneurysm; Isoquinolines; Middle Aged; Opium	1989
Pharmacokinetics of atracurium and laudanosine in the elderly. British journal of anaesthesia, 1989, Volume: 63, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Atracurium; Female; Half-Life; Humans; Isoquinolines; Male; Metabolic Clearance Rate; Opium	1989
Effect of atracurium and laudanosine on the release of 3H-noradrenaline. British journal of anaesthesia, 1989, Volume: 62, Issue:6 Topics: Animals; Atracurium; Axons; Female; Guinea Pigs; Isoquinolines; Male; Norepinephrine; Opium; Receptors, Histamine; Receptors, Muscarinic; Sympathetic Nervous System	1989
Atracurium overdose in a small infant. Anaesthesia, 1989, Volume: 44, Issue:6 Topics: Atracurium; Female; Humans; Infant; Isoquinolines; Medication Errors; Opium	1989
Generation of reactive metabolites during spontaneous degradation of atracurium in vitro. The American journal of the medical sciences, 1989, Volume: 297, Issue:1 Topics: Atracurium; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Isoquinolines; Sulfhydryl Compounds	1989
Pharmacokinetics of atracurium and laudanosine in patients with hepatic cirrhosis. British journal of anaesthesia, 1989, Volume: 62, Issue:2 Topics: Atracurium; Female; Half-Life; Humans; Isoquinolines; Liver Cirrhosis; Male; Middle Aged	1989
Magic bullets, science, and medicine. Anesthesiology, 1985, Volume: 63, Issue:6 Topics: Animals; Atracurium; Biotransformation; Brain; Isoquinolines; Neuromuscular Nondepolarizing Agents	1985
Laudanosine (a metabolite of atracurium) increases the minimum alveolar concentration of halothane in rabbits. Anesthesiology, 1985, Volume: 63, Issue:6 Topics: Animals; Atracurium; Dose-Response Relationship, Drug; Drug Interactions; Halothane; Infusions, Parenteral; Isoquinolines; Kinetics; Models, Biological; Neuromuscular Nondepolarizing Agents; Pulmonary Alveoli; Rabbits	1985
Disposition of infusions of atracurium and its metabolite, laudanosine, in patients in renal and respiratory failure in an ITU. British journal of anaesthesia, 1988, Volume: 61, Issue:5 Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Atracurium; Critical Care; Female; Humans; Isoquinolines; Male; Middle Aged; Respiratory Insufficiency	1988
The prolonged use of atracurium in a patient with tetanus. Anaesthesia, 1988, Volume: 43, Issue:11 Topics: Adult; Atracurium; Humans; Infusions, Intravenous; Isoquinolines; Male; Respiration, Artificial; Tetanus; Time Factors	1988
Pharmacokinetics of atracurium metabolites. British journal of anaesthesia, 1988, Volume: 60, Issue:4 Topics: Atracurium; Humans; Isoquinolines	1988
Clinical experience and plasma laudanosine concentrations during the infusion of atracurium in the intensive therapy unit. British journal of anaesthesia, 1987, Volume: 59, Issue:2 Topics: Adolescent; Adult; Aged; Atracurium; Child; Critical Care; Female; Humans; Infusions, Intravenous; Intermittent Positive-Pressure Ventilation; Isoquinolines; Male; Middle Aged; Time Factors	1987
Pharmacokinetics of atracurium and its metabolites in patients with normal renal function, and in patients in renal failure. British journal of anaesthesia, 1987, Volume: 59, Issue:6 Topics: Adult; Aged; Alcohols; Atracurium; Female; Half-Life; Humans; Isoquinolines; Kidney Failure, Chronic; Kinetics; Male; Mathematics; Middle Aged; Models, Biological	1987
Pharmacokinetics of atracurium and its metabolites. British journal of anaesthesia, 1986, Volume: 58 Suppl 1 Topics: Atracurium; Chronic Disease; Half-Life; Humans; Isoquinolines; Kidney Failure, Chronic; Kinetics; Liver Diseases; Metabolic Clearance Rate; Neuromuscular Blocking Agents	1986
Preponderance of hydrolysis in inactivation of atracurium: questions remain. Anesthesia and analgesia, 1986, Volume: 65, Issue:12 Topics: Animals; Atracurium; Hydrolysis; Isoquinolines; Rats	1986
Pharmacokinetics of atracurium in anaesthetized infants and children. British journal of anaesthesia, 1986, Volume: 58, Issue:11 Topics: Anesthesia, Inhalation; Atracurium; Child; Child, Preschool; Humans; Infant; Isoflurane; Isoquinolines; Kinetics; Liver; Liver Diseases; Nitrous Oxide	1986
Effect of renal failure on laudanosine excretion in man. British journal of anaesthesia, 1985, Volume: 57, Issue:11 Topics: Atracurium; Humans; Isoquinolines; Kidney Failure, Chronic; Neuromuscular Blocking Agents; Time Factors	1985
In vitro degradation of atracurium in human plasma. British journal of anaesthesia, 1985, Volume: 57, Issue:11 Topics: Atracurium; Humans; Isoquinolines; Neuromuscular Blocking Agents; Time Factors	1985
Determination of atracurium, laudanosine and related compounds in plasma by high-performance liquid chromatography. Journal of chromatography, 1985, Oct-11, Volume: 343, Issue:2 Topics: Animals; Atracurium; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dogs; Humans; Indicators and Reagents; Isoquinolines; Neuromuscular Blocking Agents; Species Specificity; Tetrahydropapaveroline	1985
The pharmacokinetics and pharmacodynamics of atracurium in patients with and without renal failure. Anesthesiology, 1984, Volume: 61, Issue:6 Topics: Anesthesia, General; Atracurium; Chromatography, Ion Exchange; Humans; Isoquinolines; Kidney Failure, Chronic; Kinetics; Models, Biological; Muscle Contraction; Neuromuscular Nondepolarizing Agents	1984
Pharmacokinetics of 1R-cis 1'R-cis atracurium besylate (51W89) and plasma laudanosine concentrations in health and chronic renal failure. British journal of anaesthesia, 1995, Volume: 75, Issue:4 Topics: Adult; Age Factors; Atracurium; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Isoquinolines; Kidney Failure, Chronic; Male; Middle Aged; Models, Biological; Neuromuscular Nondepolarizing Agents; Sex Factors; Stereoisomerism	1995
Is 51W89 an improvement compared with atracurium? British journal of anaesthesia, 1995, Volume: 74, Issue:1 Topics: Anesthetics; Atracurium; Histamine Release; Humans; Isoquinolines; Neuromuscular Blocking Agents	1995
The in vitro degradation of cisatracurium, the R, cis-R'-isomer of atracurium, in human and rat plasma. Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:2 Topics: Alcohols; Animals; Atracurium; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Isomerism; Isoquinolines; Male; Organophosphorus Compounds; Rats; Time Factors	1995
Activation of brain acetylcholine receptors by neuromuscular blocking drugs. A possible mechanism of neurotoxicity. Anesthesiology, 1994, Volume: 80, Issue:5 Topics: Acetylcholine; Anesthesia, General; Animals; Atracurium; Brain; Calcium; Convulsants; Dose-Response Relationship, Drug; Enflurane; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Isoquinolines; Kainic Acid; Male; N-Methylaspartate; Neuromuscular Nondepolarizing Agents; Neurotoxins; Nicotine; Pancuronium; Phenytoin; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Time Factors; Tubocurarine; Vecuronium Bromide	1994
Influence of incubated atracurium on rat liver function. British journal of anaesthesia, 1994, Volume: 72, Issue:3 Topics: Animals; Atracurium; Bile; Hot Temperature; Hydrogen-Ion Concentration; In Vitro Techniques; Isoquinolines; L-Lactate Dehydrogenase; Liver; Male; Rats; Time Factors	1994
Plasma laudanosine levels in patients given atracurium during liver transplantation. Anesthesia and analgesia, 1993, Volume: 76, Issue:3 Topics: Adult; Aged; Atracurium; Humans; Isoquinolines; Liver Transplantation; Middle Aged	1993
High-dose laudanosine enhances liver cell activity and bile flow during reperfusion of the liver. Transplantation proceedings, 1993, Volume: 25, Issue:2 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Aspartate Aminotransferases; Atracurium; Bile; Energy Metabolism; Isoquinolines; L-Lactate Dehydrogenase; Lactates; Liver; Male; Opium; Perfusion; Rats; Rats, Inbred Strains; Reperfusion	1993
Pharmacokinetics of 51W89: preliminary data. Acta anaesthesiologica Scandinavica. Supplementum, 1995, Volume: 106 Topics: Atracurium; Half-Life; Humans; Isomerism; Isoquinolines; Kidney; Kidney Failure, Chronic; Metabolic Clearance Rate; Neuromuscular Nondepolarizing Agents; Opium; Renal Dialysis	1995
Pharmacokinetics and pharmacodynamics of cisatracurium in patients with end-stage liver disease undergoing liver transplantation. British journal of anaesthesia, 1996, Volume: 76, Issue:5 Topics: Adult; Aged; Atracurium; Evoked Potentials; Female; Half-Life; Humans; Isomerism; Isoquinolines; Liver Failure; Liver Transplantation; Male; Middle Aged; Neuromuscular Junction; Neuromuscular Nondepolarizing Agents; Time Factors	1996
A pharmacokinetic-pharmacodynamic model for a muscle relaxant: atracurium. European journal of clinical pharmacology, 1996, Volume: 49, Issue:4 Topics: Atracurium; Isoquinolines; Models, Biological; Neuromuscular Nondepolarizing Agents	1996
Importance of the organ-independent elimination of cisatracurium. Anesthesia and analgesia, 1996, Volume: 83, Issue:5 Topics: Adult; Atracurium; Female; Half-Life; Humans; Hydrogen-Ion Concentration; Isoquinolines; Kidney; Liver; Male; Metabolic Clearance Rate; Models, Chemical; Neuromuscular Blocking Agents; Temperature; Tissue Distribution	1996
Laudanosine and atracurium concentrations in a patient receiving long-term atracurium infusion. Critical care medicine, 1998, Volume: 26, Issue:1 Topics: Adult; Atracurium; Electroencephalography; Female; Follow-Up Studies; Half-Life; Hemoglobin SC Disease; Humans; Infusions, Intravenous; Isoquinolines; Multiple Organ Failure; Neuromuscular Nondepolarizing Agents; Respiratory Distress Syndrome; Seizures	1998
Effects of neuromuscular blocking agents on excitatory transmission and gamma-aminobutyric acidA-mediated inhibition in the rat hippocampal slice. Anesthesiology, 1998, Volume: 88, Issue:4 Topics: Animals; Atracurium; Electrophysiology; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Hippocampus; Isoquinolines; Neuromuscular Blocking Agents; Rats; Rats, Sprague-Dawley; Synaptic Transmission	1998
Modulation of rat brain synaptosomal plasma membrane achieved by atracurium and its metabolite laudanosine. Intensive care medicine, 1998, Volume: 24, Issue:5 Topics: 5'-Nucleotidase; Animals; Atracurium; Brain; Ca(2+) Mg(2+)-ATPase; Cell Membrane; Central Nervous System Agents; Dose-Response Relationship, Drug; Isoquinolines; Male; Neuromuscular Depolarizing Agents; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Synaptosomes	1998
High-performance liquid chromatographic method for the determination of atracurium and laudanosine in human plasma. Application to pharmacokinetics. Journal of chromatography. B, Biomedical sciences and applications, 1999, Mar-05, Volume: 724, Issue:1 Topics: Atracurium; Calibration; Chromatography, High Pressure Liquid; Humans; Isoquinolines; Neuromuscular Nondepolarizing Agents; Reproducibility of Results; Sensitivity and Specificity	1999
The distribution of laudanosine in tissues after death from atracurium injection. International journal of legal medicine, 2000, Volume: 114, Issue:1-2 Topics: Atracurium; Autopsy; Female; Gas Chromatography-Mass Spectrometry; Humans; Isoquinolines; Middle Aged; Neuromuscular Nondepolarizing Agents; Suicide; Tissue Distribution	2000
Blockade and activation of the human neuronal nicotinic acetylcholine receptors by atracurium and laudanosine. Anesthesiology, 2001, Volume: 94, Issue:4 Topics: Animals; Atracurium; Dose-Response Relationship, Drug; Female; Humans; Isoquinolines; Neuromuscular Nondepolarizing Agents; Nicotinic Antagonists; Receptors, Nicotinic; Xenopus	2001
The pharmacokinetics of cisatracurium in patients with acute respiratory distress syndrome. Anesthesia and analgesia, 2001, Volume: 93, Issue:2 Topics: Adult; Atracurium; Female; Humans; Isoquinolines; Male; Middle Aged; Neuromuscular Blocking Agents; Respiratory Distress Syndrome; Time Factors	2001
Pharmacodynamics and atracurium and laudanosine concentrations during a fixed continuous infusion of atracurium in mechanically ventilated patients with acute respiratory distress syndrome. Anaesthesia and intensive care, 2002, Volume: 30, Issue:4 Topics: Aged; Atracurium; Central Nervous System Agents; Female; Humans; Infusions, Intravenous; Isoquinolines; Male; Middle Aged; Neuromuscular Blockade; Neuromuscular Nondepolarizing Agents; Respiration, Artificial; Respiratory Distress Syndrome	2002
The possible neuroprotective effect of laudanosine, an atracurium and cisatracurium metabolite. Acta anaesthesiologica Scandinavica, 2003, Volume: 47, Issue:6 Topics: Atracurium; Central Nervous System Agents; Humans; Isoquinolines; Neuromuscular Nondepolarizing Agents; Neuroprotective Agents; Neurosurgical Procedures	2003
Anesthesiologist suicide with atracurium. Journal of analytical toxicology, 2006, Volume: 30, Issue:2 Topics: Anesthesiology; Atracurium; Central Nervous System Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; Cyclohexanols; Desvenlafaxine Succinate; Forensic Medicine; Humans; Isoquinolines; Male; Middle Aged; Neuromuscular Depolarizing Agents; Opium; Suicide; Venlafaxine Hydrochloride	2006
Simultaneous determination of atracurium and its metabolite laudanosine in post-mortem fluids by liquid chromatography/multiple-stage mass spectrometry on an ion trap. Rapid communications in mass spectrometry : RCM, 2007, Volume: 21, Issue:18 Topics: Atracurium; Body Fluids; Chromatography, High Pressure Liquid; Complex Mixtures; Humans; Isoquinolines; Neuromuscular Nondepolarizing Agents; Postmortem Changes; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization	2007
[Determination of atracurium and laudanosine in dog plasma during cardiopulmonary bypass by high performance liquid chromatography with fluorometric detection]. Se pu = Chinese journal of chromatography, 2013, Volume: 31, Issue:6 Topics: Animals; Atracurium; Calibration; Cardiopulmonary Bypass; Chromatography, High Pressure Liquid; Dogs; Fluorometry; Isoquinolines; Verapamil	2013
Capillary electrophoresis with electrochemiluminescence detection for the simultaneous determination of cisatracurium besylate and its degradation products in pharmaceutical preparations. Journal of separation science, 2015, Volume: 38, Issue:13 Topics: Atracurium; Electrophoresis, Capillary; Isoquinolines; Limit of Detection; Luminescence; Pharmaceutical Preparations; Reproducibility of Results	2015
Real-time potentiometric sensor; an innovative tool for monitoring hydrolysis of chemo/bio-degradable drugs in pharmaceutical sciences. Journal of pharmaceutical and biomedical analysis, 2018, May-30, Volume: 154 Topics: Atracurium; Biosensing Techniques; Chemistry, Pharmaceutical; Hydrolysis; Ion-Selective Electrodes; Isoquinolines; Potentiometry	2018
Effect of age on cis-atracurium besylate pharmacokinetics following a single 1 mg kg Veterinary anaesthesia and analgesia, 2019, Volume: 46, Issue:5 Topics: Anesthesia; Animals; Animals, Newborn; Atracurium; Female; Injections, Intravenous; Isoquinolines; Neuromuscular Nondepolarizing Agents; Prospective Studies; Swine	2019