atractyloside and mastoparan

atractyloside has been researched along with mastoparan* in 1 studies

Other Studies

1 other study(ies) available for atractyloside and mastoparan

ArticleYear
Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Aug-15, Volume: 17, Issue:16

    Apoptosis is a fundamental process required for normal development of the nervous system and is triggered during neurodegenerative disease. To dissect the molecular events leading to neuronal cell death, we have developed a cell-free model of neuronal apoptosis. The model faithfully reproduces key elements of apoptosis, including chromatin condensation, DNA fragmentation, caspase activation/processing, and selective substrate cleavage. We report that cell-free apoptosis is activated in premitochondrial, mitochondrial, and postmitochondrial phases by tamoxifen, mastoparan, and cytochrome c, respectively, allowing a functional ordering of these proapoptotic modulators. Furthermore, this is the first report of mitochondrial-mediated activation of cell-free apoptosis in a cell extract. Although Bcl-2 blocks activation at the premitochondrial and mitochondrial levels, it does not affect the postmitochondrial level. The cell-free system described here provides a valuable tool to elucidate the molecular events leading to neuronal cell death.

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Atractyloside; Caspase 3; Caspases; Cell Extracts; Cell-Free System; Cells, Cultured; Cerebellum; Cysteine Endopeptidases; Cytochrome c Group; Enzyme Inhibitors; Enzyme Precursors; Estrogen Antagonists; Intercellular Signaling Peptides and Proteins; Mitochondria; Molecular Sequence Data; Neurons; Peptides; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Sequence Homology, Amino Acid; Staurosporine; Tamoxifen; Wasp Venoms

1997