atractylenolide-ii has been researched along with kaempferol* in 1 studies
1 other study(ies) available for atractylenolide-ii and kaempferol
| Article | Year |
|---|---|
Screening active components of modified Xiaoyao powder as NRF2 agonists.
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) regulates antioxidant enzymes and phase II detoxifying enzymes, such as NAD(P)H: quinone oxidoreductase 1 (NQO1). Modified Xiaoyao powder (MXP) is most frequently used in the prevention and treatment of breast cancer in China. This study aimed to screen active components of MXP for antioxidant stress and chemoprevention, which depend on NRF2-NQO1 signalling pathway. A total of 25 monomeric compounds contained in MXP were screened using an antioxidant response element-luciferase reporter. The most potent antioxidant response element-luciferase inducers were chosen to further examine their effects on NRF2 and NQO1 in MCF-7 cells. These results were then confirmed by determining the oxidative stress levels and chemopreventive effect on inhibiting carcinogenesis transformation in NRF2 knockdown (NRF2 Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cells, Cultured; Chemoprevention; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Humans; Kaempferols; Lactones; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Plant Extracts; Quercetin; Sesquiterpenes; Structure-Activity Relationship | 2017 |