Page last updated: 2024-08-25

atovaquone and pyrimethamine

atovaquone has been researched along with pyrimethamine in 71 studies

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	19 (26.76)	18.2507
2000's	22 (30.99)	29.6817
2010's	26 (36.62)	24.3611
2020's	4 (5.63)	2.80

Authors

Authors	Studies
Bibal, B; Bouammali, B; Cherkaoui, O; Fillion, H; Nebois, P; Pautet, F; Pétavy, AF; Sarciron, ME; Walchshofer, N	1
Jomaa, H; Mitsch, A; Schlitzer, M; Wiesner, J; Wissner, P	1
Baniecki, ML; Clardy, J; Wirth, DF	1
Aubert, D; Bouldouyre, MA; Derouin, F; Garin, JF; Meneceur, P; Menotti, J; Sauvage, V; Villena, I	1
Bertaux, L; Bogreau, H; Bouchiba, H; Garnotel, E; Kraemer, P; Parzy, D; Pradines, B; Rogier, C; Savini, H; Simon, F	1
Lombardo, F; Obach, RS; Waters, NJ	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Beck, HP; Brun, R; Cohen, SB; Dartois, V; Dharia, NV; Diagana, TT; Fidock, DA; Goh, A; González-Páez, GE; Jegla, T; Keller, TH; Lakshminarayana, SB; Lee, MC; McNamara, C; Nosten, F; Plouffe, DM; Renia, L; Rottmann, M; Russell, B; Schmitt, EK; Seitz, P; Spencer, KR; Suwanarusk, R; Tan, J; Winzeler, EA; Yeung, BK; Zou, B	1
Bathurst, I; Buckner, FS; Burrows, J; Charman, SA; Charman, WN; Creason, S; Deng, X; El Mazouni, F; Floyd, DM; Gujjar, R; Matthews, D; Phillips, MA; Rathod, PK; Shackleford, DM; White, J; White, KL	1
Lopes, F; Moreira, R; Mota, MM; Prudêncio, M; Rodrigues, T	1
Clardy, J; Derbyshire, ER; Mota, MM; Prudêncio, M	1
Fidock, DA; Flannery, EL; Winzeler, EA	1
Angulo-Barturen, I; Avery, VM; Awasthy, D; Balasubramanian, V; Bandodkar, B; Barde, SP; Bharath, S; Chinnapattu, M; Duffy, S; Ferrer, S; Gamo, FJ; Hameed P, S; Hosagrahara, V; Iyer, PS; Jatheendranath, S; Jiménez-Díaz, MB; Kavanagh, S; Koushik, K; Lukens, AK; Magistrado, PA; Manjrekar, P; Martínez, MS; Morayya, S; Mukherjee, K; Narayan, C; Narayanan, S; Panduga, V; Patil, V; Prabhakar, KR; Raichurkar, A; Ramachandran, S; Rautela, N; Reddy, J; Rudrapatna, SS; Sambandamurthy, VK; Sanz, LM; Saralaya, R; Shanbag, G; Sinha, A; Srivastava, A; Viswanath, P; Waterson, D; Wirth, DF	1
Achar, V; Angulo-Barturen, I; Avery, VM; Awasthy, D; Bharath, S; Coburn-Flynn, O; Duffy, S; Ferrer, S; Fidock, DA; Gamo, FJ; Hameed P, S; Hosagrahara, V; Iyer, PS; Jiménez-Díaz, MB; Kavanagh, S; Lee, MC; Martínez, MS; Menasinakai, S; Morayya, S; Nanduri, R; Narayanan, S; Panduga, V; Prabhakar, KR; Raichurkar, A; Ramachandran, S; Rautela, N; Reddy, J; Sambandamurthy, VK; Sanz, LM; Saralaya, R; Shanbhag, G; Srivastava, A; Waterson, D	1
Chinnapattu, M; Iyer, PS; Sathiyanarayanan, KI	1
Iyer, PS; Kannan, M; Khan, FR; Raichurkar, AV	1
Azas, N; Basmaciyan, L; Cohen, A; Crozet, MD; Dallemagne, P; Deharo, E; Dumètre, A; Hutter, S; Laget, M; Lancelot, JC; Lesnard, A; Lorthiois, A; Mazier, D; Paloque, L; Rathelot, P; Rault, S; Sibley, CH; Suzanne, P; Valentin, A; Vanelle, P; Verhaeghe, P	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Campbell, S; Charman, SA; Chen, G; Dias, LC; Krake, SH; Martinez, PDG; McLaren, J; Ryan, E; White, K; Willis, P	1
Barnard, L; Birkholtz, LM; Botha, M; Brunschwig, C; Burrows, JN; Chibale, K; Churchyard, A; Coetzer, TL; Denti, P; Egan, TJ; Laing, L; Lauterbach, S; Machado, M; Ndubi, F; Njogu, PM; Njoroge, M; Nondaba, S; Okombo, J; Prudêncio, M; Reader, J; Singh, K; Wiesner, L; Wilkinson, C; Wittlin, S; Yeates, C	1
Berry, P; Campo, B; Cao, J; Ciaravino, V; Easom, EE; Erve, JCL; Freund, YR; Gamo, FJ; Guo, D; Jacobs, RT; Plattner, JJ; Rosenthal, PJ; Sanz, LM; Zhang, YK	1
Aguiar, ACC; Correia, CRD; Costa, JL; de Souza, GE; Garcia, CRS; Garcia, ML; Guido, RVC; Nakabashi, M; Oliva, G; Panciera, M; Simão Dos Santos, EF; Singh, MK	1
Aguiar, ACC; de Souza, JO; Fagundez, C; Gamo, FJ; Guido, RVC; Ottilie, S; Peña, S; Sanz, LM; Scarone, L; Sellanes, D; Serra, GL; Stewart, L; Winzeler, EA; Yardley, V	1
Cheong, SL; Ng, CH; Tibon, NS	1
Akao, Y; Avery, VM; Charman, SA; Chen, G; Chen, X; Chiu, FCK; Cho, N; Crespo, B; Dechering, KJ; Duffy, S; Kamaura, M; Katneni, K; Laleu, B; Lucantoni, L; Ochida, A; Sanz, LM; Shackleford, DM; Sturm, A; Wang, B; White, KL; Wittlin, S	1
da Silva, RB; de Souza, W; Garden, SJ; Martins-Duarte, ES; Pires, HS; Portes, JA	1
Araujo, FG; Huskinson-Mark, J; Remington, JS	1
Winstanley, P	1
Bouboulis, DA; Frieri, M; Madden, J; Rubinstein, A; Shliozberg, J	1
Hughes, WT; Killmar, JT; Oz, HS	1
Cardenal, C; Gatell, JM; Guelar, A; Mallolas, J; Miró, JM; Soriano, E; Zamora, L	1
Brun-Pascaud, M; Chau, F; Derouin, F; Girard, PM; Pocidalo, JJ; Simonpoli, AM	1
Araujo, FG; Remington, JS; Slifer, T	1
Derouin, F; Pudney, M; Romand, S	1
Araujo, FG; Lin, T; Remington, JS	1
Davies, CS; Nicholas, JC; Pudney, M; Sinden, RE	1
Araujo, FG; Remington, JS; Suzuki, Y	1
Gourdon, D; Katlama, C; Lapierre, D; Mouthon, B; Rousseau, F	1
Brettle, RP; Burns, SM; Flegg, PJ; Laing, RB; Leen, CL	1
Cirioni, O; Giacometti, A; Scalise, G	1
Christopherson, RI; Rieckmann, KH; Seymour, KK; Yeo, AE	1
Fishman, JA	1
Davis, TM	1
Bustos, DG; Canete-Miguel, E; Canfield, CJ; Hutchinson, DB	1
Watt, G	1
Lakritz, J; Marsh, AE; Mullins, AL	1
Walker, MJ	1
Campos, P; Canfield, CJ; Clendenes, M; Hutchinson, DB; Llanos-Cuentas, A	1
Gatton, ML; Hogarth, W; Saul, A	1
Andersen, J; Bosler, EM; Chirgwin, K; Hafner, R; Jayaweera, DT; Leport, C; Luft, BJ; McAuliffe, V; Morlat, P; Rajicic, N; Remington, J; Roque, C; Vilde, JL	1
Jones, K; Ward, SA	1
Bedos, JP; Bruneel, F; Danis, M; Gachot, B; Regnier, B; Vachon, F; Wolff, M	1
Fischer, PR; Stauffer, W	1
Bienzle, U; Ehrhardt, S; Jelinek, T; Mockenhaupt, FP; Muehlen, M; Otchwemah, R; Schreiber, J	1
Arasteh, K; Borner, K; Bushrab, FN; Dunay, IR; Fitzner, R; Heimesaat, MM; Kurowski, M; Liesenfeld, O; Müller, RH; Stocker, H	1
Jiang, S; McConkey, GA; McRobert, L; Stead, A	1
Bennett, S; Fielding, K; Greenwood, B; Malunga, P; Mulenga, M; Shulman, C; Thuma, P	1
Alloueche, A; Bennett, S; Fielding, K; Greenwood, BM; Malunga, F; Mulenga, M; Shulman, C; Thuma, PE	1
Chollet, J; Santo-Tomas, J; Scheurer, C; Snyder, C; Wittlin, S	1
Androudi, S; Bhaila, I; Fiore, T; Iaccheri, B; Janjua, S; Papadaki, T; Stephen Foster, C	1
bin Reza, F; Chiodini, PL; Doherty, JF; Fifer, H; Gothard, P; Haustein, T; Nicholas, M; Njimgye-Tekumafor, NE; Pearce, RJ; Polley, SD; Sutherland, CJ	1
Balu, L; Chevret, L; Habes, D; Orostegui, L; Pussard, E	1
Terlouw, DJ; van Eijk, AM	1
Ensom, MH; Wilby, KJ	1
Combrinck, JM; Egan, TJ; Fong, KY; Gibhard, L; Smith, PJ; Wright, DW	1
Davis, LA; Davis, PH; Judge, AK; Larson, JJ; Neville, AJ; Vennerstrom, JL; Wang, X; Zach, SJ	1
Hoepelman, AI; Marzuki, S; Nuralitha, S; Roelands, J; Siregar, JE; Syafruddin, D; Verhoef, J	1
Banura, P; Guler, JL; Houpt, E; Huang, F; Jacob, ST; Laufer, MK; Liu, J; Moore, CC; Pholwat, S; Stroup, S	1
Almela, MJ; Angulo-Barturen, Í; Bamborough, P; Burrows, J; Calderón, F; Cammack, N; Castañeda, P; Chaparro, MJ; Coterón, JM; Crespo, B; de Cozar, C; de la Rosa, JC; de Mercado, J; Díaz, B; Drewes, G; Fernández, E; Ferrer-Bazaga, S; Fraile, MT; Gamo, FJ; Ghidelli-Disse, S; Gómez, R; Haselden, J; Huss, S; Jiménez Díaz, MB; Lafuente-Monasterio, MJ; León, ML; Macdonald, SJF; Martín Hernando, JI; Martínez-Martínez, MS; Prats, S; Puente, M; Rodríguez, A; Rueda, L; Sandoval, E; Selenski, C; Vidal, J; Willis, P; Wilson, DM; Witty, M	1
De Souza, W; Portes, JA	1
Anvikar, AR; Ashley, EA; Chandramohan, D; Cohee, LM; D'Alessandro, U; Genton, B; Gilder, ME; Guérin, PJ; Juma, E; Kalilani-Phiri, L; Kennon, K; Kuepfer, I; Laufer, MK; Lwin, KM; Mansoor, R; McGready, R; Meshnick, SR; Mosha, D; Mwapasa, V; Mwebaza, N; Nambozi, M; Ndiaye, JA; Nosten, F; Nyunt, M; Ogutu, B; Parikh, S; Paw, MK; Phyo, AP; Pimanpanarak, M; Piola, P; Rijken, MJ; Saito, M; Sriprawat, K; Stepniewska, K; Tagbor, HK; Tarning, J; Tinto, H; Valéa, I; Valecha, N; White, NJ; Wiladphaingern, J	1

Reviews

9 review(s) available for atovaquone and pyrimethamine

Article	Year
Targeting the liver stage of malaria parasites: a yet unmet goal. Journal of medicinal chemistry, 2012, Feb-09, Volume: 55, Issue:3 Topics: Animals; Antimalarials; Humans; Life Cycle Stages; Liver; Malaria; Plasmodium; Structure-Activity Relationship	2012
Using genetic methods to define the targets of compounds with antimalarial activity. Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20 Topics: Animals; Anopheles; Antimalarials; Drug Resistance; Genetic Association Studies; Genome, Protozoan; Humans; Malaria, Falciparum; Molecular Targeted Therapy; Plasmodium falciparum	2013
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Current progress in antimalarial pharmacotherapy and multi-target drug discovery. European journal of medicinal chemistry, 2020, Feb-15, Volume: 188 Topics: Animals; Antimalarials; Artemisinins; Drug Discovery; Drug Resistance; Humans; Malaria; Molecular Structure; Paclitaxel; Quinolines	2020
Prevention of infection due to Pneumocystis carinii. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:5 Topics: Animals; Antibiotic Prophylaxis; Antifungal Agents; Atovaquone; Clindamycin; Dapsone; Fungal Vaccines; Humans; Microbial Sensitivity Tests; Naphthoquinones; Pentamidine; Pneumocystis; Pneumonia, Pneumocystis; Pyrimethamine; Trimethoprim, Sulfamethoxazole Drug Combination	1998
Azithromycin for treating uncomplicated malaria. The Cochrane database of systematic reviews, 2011, Feb-16, Issue:2 Topics: Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Atovaquone; Azithromycin; Chloroquine; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Mefloquine; Proguanil; Pyrimethamine; Randomized Controlled Trials as Topic; Sulfadoxine; Treatment Failure	2011
Pharmacokinetics of antimalarials in pregnancy: a systematic review. Clinical pharmacokinetics, 2011, Nov-01, Volume: 50, Issue:11 Topics: Anti-Bacterial Agents; Antimalarials; Artemisinins; Atovaquone; Chloroquine; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Humans; Lumefantrine; Malaria; Mefloquine; Pregnancy; Pregnancy Complications, Parasitic; Proguanil; Pyrimethamine; Quinine; Sulfadoxine	2011
Clinically Available Medicines Demonstrating Anti-Toxoplasma Activity. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:12 Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antiprotozoal Agents; Antipsychotic Agents; Atovaquone; Clindamycin; Drug Repositioning; Humans; Macrolides; Parasitic Sensitivity Tests; Pyrimethamine; Sulfadiazine; Toxoplasma; Toxoplasmosis	2015
Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis. The Lancet. Infectious diseases, 2020, Volume: 20, Issue:8 Topics: Amodiaquine; Anti-Bacterial Agents; Antimalarials; Artemisinins; Artesunate; Atovaquone; Clindamycin; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Mefloquine; Pregnancy; Pregnancy Complications, Parasitic; Proguanil; Pyrimethamine; Quinine; Quinolines; Sulfadoxine	2020

Trials

6 trial(s) available for atovaquone and pyrimethamine

Article	Year
Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. Atovaquone Expanded Access Group. AIDS (London, England), 1996, Volume: 10, Issue:10 Topics: Acquired Immunodeficiency Syndrome; Adult; Antiprotozoal Agents; Atovaquone; Clindamycin; Encephalitis; Female; Humans; Male; Naphthoquinones; Pyrimethamine; Recurrence; Risk Factors; Sulfadiazine; Survival Analysis; Time Factors; Toxoplasmosis, Cerebral	1996
Atovaquone-proguanil compared with chloroquine and chloroquine-sulfadoxine-pyrimethamine for treatment of acute Plasmodium falciparum malaria in the Philippines. The Journal of infectious diseases, 1999, Volume: 179, Issue:6 Topics: Antimalarials; Atovaquone; Chloroquine; Drug Therapy, Combination; Folic Acid Antagonists; Humans; Malaria, Falciparum; Naphthoquinones; Philippines; Proguanil; Pyrimethamine; Sulfadoxine	1999
Atovaquone and proguani hydrochloride compared with chloroquine or pyrimethamine/sulfodaxine for treatment of acute Plasmodium falciparum malaria in Peru. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 2001, Volume: 5, Issue:2 Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Atovaquone; Chloroquine; Drug Combinations; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Male; Microbial Sensitivity Tests; Middle Aged; Naphthoquinones; Peru; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome	2001
Randomized phase II trial of atovaquone with pyrimethamine or sulfadiazine for treatment of toxoplasmic encephalitis in patients with acquired immunodeficiency syndrome: ACTG 237/ANRS 039 Study. AIDS Clinical Trials Group 237/Agence Nationale de Recherche Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002, May-01, Volume: 34, Issue:9 Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Adult; AIDS-Related Opportunistic Infections; Animals; Antiprotozoal Agents; Atovaquone; Drug Therapy, Combination; Encephalitis; Female; Follow-Up Studies; Humans; Male; Naphthoquinones; Pyrimethamine; Sulfadiazine; Time Factors; Toxoplasma; Treatment Outcome	2002
Folic acid treatment of Zambian children with moderate to severe malaria anemia. The American journal of tropical medicine and hygiene, 2006, Volume: 74, Issue:6 Topics: Anemia; Animals; Antimalarials; Atovaquone; Child; Child, Preschool; Drug Combinations; Folic Acid; Hematinics; Humans; Infant; Malaria, Falciparum; Naphthoquinones; Parasitemia; Population Density; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Failure; Zambia	2006
A randomised, double-blind, placebo-controlled trial of atovaquone-proguanil vs. sulphadoxine-pyrimethamine in the treatment of malarial anaemia in Zambian children. Tropical medicine & international health : TM & IH, 2006, Volume: 11, Issue:11 Topics: Anemia; Antimalarials; Atovaquone; Child; Child, Preschool; Double-Blind Method; Drug Combinations; Female; Humans; Infant; Malaria, Falciparum; Male; Parasitemia; Prevalence; Proguanil; Pyrimethamine; Sulfadoxine; Time Factors; Treatment Failure; Zambia	2006

Other Studies

56 other study(ies) available for atovaquone and pyrimethamine

Article	Year
Quinonic derivatives active against a virulent strain of Toxoplasma gondii. Synthesis of 2-methylfuro[2,3-g]- and [3,2-g]isoquinolinetriones. Bioorganic & medicinal chemistry letters, 2000, May-01, Volume: 10, Issue:9 Topics: Animals; Antiprotozoal Agents; Cell Line; Furans; Humans; Monocytes; Quinolines; Toxoplasma	2000
Structure-activity relationships of novel anti-malarial agents. Part 2: cinnamic acid derivatives. Bioorganic & medicinal chemistry letters, 2001, Feb-12, Volume: 11, Issue:3 Topics: Animals; Antimalarials; Cinnamates; Combinatorial Chemistry Techniques; Inhibitory Concentration 50; Microbial Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship	2001
High-throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2 Topics: Animals; Biological Assay; Child, Preschool; DNA, Protozoan; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Female; Humans; Indoles; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Pregnancy	2007
In vitro susceptibility of various genotypic strains of Toxoplasma gondii to pyrimethamine, sulfadiazine, and atovaquone. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:4 Topics: Animals; Antiprotozoal Agents; Atovaquone; Genotype; Humans; Inhibitory Concentration 50; Parasitic Sensitivity Tests; Pyrimethamine; Sulfadiazine; Toxoplasma	2008
First case of emergence of atovaquone-proguanil resistance in Plasmodium falciparum during treatment in a traveler in Comoros. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6 Topics: Animals; Antimalarials; Atovaquone; Comoros; Drug Resistance; France; Genotype; Humans; Malaria, Falciparum; Male; Parasitic Sensitivity Tests; Plasmodium falciparum; Proguanil; Travel; Treatment Failure	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Spiroindolones, a potent compound class for the treatment of malaria. Science (New York, N.Y.), 2010, Sep-03, Volume: 329, Issue:5996 Topics: Adenosine Triphosphatases; Animals; Antimalarials; Cell Line; Drug Discovery; Drug Resistance; Erythrocytes; Female; Genes, Protozoan; Humans; Indoles; Malaria; Male; Mice; Models, Molecular; Mutant Proteins; Mutation; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Plasmodium vivax; Protein Synthesis Inhibitors; Protozoan Proteins; Rats; Rats, Wistar; Spiro Compounds	2010
Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. Journal of medicinal chemistry, 2011, Jun-09, Volume: 54, Issue:11 Topics: Animals; Antimalarials; Dihydroorotate Dehydrogenase; Disease Models, Animal; Drug Design; Drug Discovery; Enzyme Inhibitors; Humans; Malaria; Mice; Microsomes, Liver; Molecular Structure; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium berghei; Plasmodium falciparum; Protein Binding; Pyrimidines; Solubility; Structure-Activity Relationship; Triazoles	2011
Liver-stage malaria parasites vulnerable to diverse chemical scaffolds. Proceedings of the National Academy of Sciences of the United States of America, 2012, May-29, Volume: 109, Issue:22 Topics: Animals; Anopheles; Antimalarials; Drug Evaluation, Preclinical; Hep G2 Cells; Humans; Inhibitory Concentration 50; Insect Vectors; Life Cycle Stages; Liver; Malaria; Malaria, Falciparum; Male; Mice; Mice, Inbred C57BL; Plasmodium berghei; Plasmodium falciparum; Treatment Outcome	2012
Aminoazabenzimidazoles, a novel class of orally active antimalarial agents. Journal of medicinal chemistry, 2014, Jul-10, Volume: 57, Issue:13 Topics: Animals; Antimalarials; Benzimidazoles; Biological Availability; Cell Line, Tumor; Cell Survival; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Mice; Plasmodium falciparum; Small Molecule Libraries; Structure-Activity Relationship	2014
N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds. Journal of medicinal chemistry, 2014, Aug-14, Volume: 57, Issue:15 Topics: Aminopyridines; Animals; Antimalarials; Benzimidazoles; Hepatocytes; Humans; Malaria; Mice, SCID; Microsomes, Liver; Plasmodium berghei; Plasmodium falciparum; Rats; Structure-Activity Relationship	2014
Synthesis and biological evaluation of adamantane-based aminophenols as a novel class of antiplasmodial agents. Bioorganic & medicinal chemistry letters, 2015, Feb-15, Volume: 25, Issue:4 Topics: Adamantane; Aminophenols; Animals; Antimalarials; Cell Line; Humans; Plasmodium falciparum	2015
Synthesis and in vitro evaluation of novel 8-aminoquinoline-pyrazolopyrimidine hybrids as potent antimalarial agents. Bioorganic & medicinal chemistry letters, 2015, Mar-01, Volume: 25, Issue:5 Topics: Aminoquinolines; Antimalarials; Humans; Malaria, Falciparum; Molecular Docking Simulation; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrazoles; Pyrimidines; Structure-Activity Relationship	2015
Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium. European journal of medicinal chemistry, 2015, May-05, Volume: 95 Topics: Animals; Antimalarials; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Drug Discovery; Erythrocytes; Hep G2 Cells; Humans; Liver; Malaria; Male; Mice; Parasitemia; Plasmodium falciparum; Pyrimidines; Structure-Activity Relationship; Trophozoites	2015
Novel inhibitors of Plasmodium falciparum based on 2,5-disubstituted furans. European journal of medicinal chemistry, 2017, Jan-27, Volume: 126 Topics: Amines; Animals; Antimalarials; Drug Design; Drug Stability; Furans; Half-Life; Humans; Mice; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship	2017
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model. Journal of medicinal chemistry, 2017, 02-23, Volume: 60, Issue:4 Topics: Animals; Antimalarials; Benzimidazoles; Life Cycle Stages; Malaria; Male; Mice; Plasmodium berghei; Structure-Activity Relationship	2017
Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate. Journal of medicinal chemistry, 2017, 07-13, Volume: 60, Issue:13 Topics: Amides; Animals; Antimalarials; Boron Compounds; Dogs; Female; Humans; Malaria; Malaria, Falciparum; Male; Mice; Plasmodium berghei; Plasmodium falciparum; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	2017
Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with in Vivo Activity. Journal of medicinal chemistry, 2018, 07-12, Volume: 61, Issue:13 Topics: Animals; Antimalarials; Drug Design; Mice; Models, Molecular; Molecular Conformation; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Quinolines	2018
Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing ACS medicinal chemistry letters, 2019, Jan-10, Volume: 10, Issue:1 Topics:	2019
Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials. Journal of medicinal chemistry, 2021, 09-09, Volume: 64, Issue:17 Topics: Administration, Oral; Animals; Antimalarials; Humans; Malaria, Falciparum; Mice; Molecular Structure; Plasmodium falciparum; Quinazolinones; Structure-Activity Relationship	2021
In vitro activity of N-phenyl-1,10-phenanthroline-2-amines against tachyzoites and bradyzoites of Toxoplasma gondii. Bioorganic & medicinal chemistry, 2021, 11-15, Volume: 50 Topics: Antiprotozoal Agents; Dose-Response Relationship, Drug; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Toxoplasma	2021
Evaluation of the effect of drugs on the cyst form of Toxoplasma gondii. The Journal of infectious diseases, 1991, Volume: 164, Issue:1 Topics: Adenine; Animals; Anti-Infective Agents; Atovaquone; Azithromycin; Brain; Clindamycin; Coccidiostats; Erythromycin; Fluorouracil; Mice; Mice, Inbred CBA; Naphthoquinones; Pyrimethamine; Sulfadiazine; Toxoplasma	1991
Drug treatment of toxoplasmic encephalitis in acquired immunodeficiency syndrome. Postgraduate medical journal, 1995, Volume: 71, Issue:837 Topics: AIDS-Related Opportunistic Infections; Atovaquone; Clindamycin; Coccidiostats; Humans; Naphthoquinones; Pyrimethamine; Sulfadiazine; Toxoplasmosis, Cerebral	1995
Cerebral toxoplasmosis in childhood and adult HIV infection treated with 1-4 hydroxynaphthoquinone and rapid desensitization with pyrimethamine. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1995, Volume: 74, Issue:6 Topics: Adult; AIDS-Related Opportunistic Infections; Antiprotozoal Agents; Atovaquone; Child; Desensitization, Immunologic; Female; HIV Infections; Humans; Naphthoquinones; Pyrimethamine; Toxoplasmosis, Cerebral	1995
Relative potency of 10 drugs with anti-Pneumocystis carinii activity in an animal model. The Journal of infectious diseases, 1994, Volume: 170, Issue:4 Topics: Animals; Anti-Infective Agents; Atovaquone; Azithromycin; Clarithromycin; Clindamycin; Clinical Trials as Topic; Dapsone; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Humans; Naphthoquinones; Pentamidine; Pneumocystis Infections; Proguanil; Pyrimethamine; Rats; Sulfadoxine; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1994
[Therapeutic alternatives for cases of cerebral toxoplasmosis in patients with AIDS: clarithromycin and atovaquone]. Enfermedades infecciosas y microbiologia clinica, 1994, Volume: 12, Issue:3 Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Atovaquone; Clarithromycin; Clindamycin; Drug Therapy, Combination; Folic Acid; Humans; Male; Naphthoquinones; Pyrimethamine; Sulfadiazine; Toxoplasma; Toxoplasmosis, Cerebral	1994
Experimental evaluation of combined prophylaxis against murine pneumocystosis and toxoplasmosis. The Journal of infectious diseases, 1994, Volume: 170, Issue:3 Topics: Animals; Antifungal Agents; Antiprotozoal Agents; Atovaquone; Brain; Dapsone; Drug Therapy, Combination; Liver; Lung; Male; Mice; Naphthoquinones; Pneumocystis; Pneumocystis Infections; Pyrimethamine; Rats; Rats, Wistar; Roxithromycin; Spleen; Toxoplasma; Toxoplasmosis, Animal; Trimethoprim, Sulfamethoxazole Drug Combination	1994
Rifabutin is active in murine models of toxoplasmosis. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:3 Topics: Animals; Antiprotozoal Agents; Atovaquone; Brain; Clindamycin; Drug Therapy, Combination; Female; Mice; Mice, Inbred CBA; Naphthoquinones; Pyrimethamine; Rifabutin; Sulfadiazine; Toxoplasmosis, Animal; Toxoplasmosis, Cerebral	1994
In vitro and in vivo activities of the hydroxynaphthoquinone atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, or minocycline against Toxoplasma gondii. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:11 Topics: Animals; Antiprotozoal Agents; Atovaquone; Clarithromycin; Coccidiostats; Drug Combinations; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Kinetics; Mice; Minocycline; Naphthoquinones; Pyrimethamine; Sulfadiazine; Toxoplasma; Toxoplasmosis, Animal	1993
The activity of atovaquone (566C80) in murine toxoplasmosis is markedly augmented when used in combination with pyrimethamine or sulfadiazine. The Journal of infectious diseases, 1993, Volume: 167, Issue:2 Topics: Animals; Antiprotozoal Agents; Atovaquone; Drug Synergism; Drug Therapy, Combination; Female; Mice; Naphthoquinones; Pyrimethamine; Sulfadiazine; Toxoplasmosis, Animal	1993
The novel hydroxynaphthoquinone 566C80 inhibits the development of liver stages of Plasmodium berghei cultured in vitro. Parasitology, 1993, Volume: 106 ( Pt 1) Topics: Animals; Antimalarials; Antiprotozoal Agents; Atovaquone; Dose-Response Relationship, Drug; Humans; Liver; Morphogenesis; Naphthoquinones; Plasmodium berghei; Pyrimethamine; Tumor Cells, Cultured	1993
Use of rifabutin in combination with atovaquone, clindamycin, pyrimethamine, or sulfadiazine for treatment of toxoplasmic encephalitis in mice. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1996, Volume: 15, Issue:5 Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antiprotozoal Agents; Atovaquone; Brain; Clindamycin; Disease Models, Animal; Drug Therapy, Combination; Encephalitis; Female; Mice; Mice, Inbred CBA; Naphthoquinones; Pyrimethamine; Rifabutin; Sulfadiazine; Toxoplasmosis, Cerebral; Treatment Outcome	1996
Clinical features, outcome and survival from cerebral toxoplasmosis in Edinburgh AIDS patients. International journal of STD & AIDS, 1996, Volume: 7, Issue:4 Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Atovaquone; Autopsy; Azithromycin; Brain; CD4 Lymphocyte Count; Clindamycin; Drug Therapy, Combination; Female; Humans; Incidence; Lymphoma, AIDS-Related; Male; Middle Aged; Naphthoquinones; Pyrimethamine; Retrospective Studies; Sulfadiazine; Toxoplasmosis, Cerebral; United Kingdom	1996
In-vitro activity of macrolides alone and in combination with artemisin, atovaquone, dapsone, minocycline or pyrimethamine against Cryptosporidium parvum. The Journal of antimicrobial chemotherapy, 1996, Volume: 38, Issue:3 Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Artemisinins; Atovaquone; Cryptosporidiosis; Cryptosporidium parvum; Dapsone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Lactones; Macrolides; Minocycline; Naphthoquinones; Pyrimethamine; Sesquiterpenes	1996
Effects of folic and folinic acids in the activities of cycloguanil and WR99210 against Plasmodium falciparum in erythrocytic culture. Annals of tropical medicine and parasitology, 1997, Volume: 91, Issue:1 Topics: Animals; Antimalarials; Atovaquone; Drug Interactions; Folic Acid; Humans; Leucovorin; Naphthoquinones; Plasmodium falciparum; Proguanil; Purine Nucleotides; Pyrimethamine; Pyrimidine Nucleotides; Triazines	1997
Adverse effects of antimalarial prophylactic drugs: an important consideration in the risk-benefit equation. The Annals of pharmacotherapy, 1998, Volume: 32, Issue:10 Topics: Animals; Anti-Bacterial Agents; Antimalarials; Atovaquone; Azithromycin; Chloroquine; Drug Therapy, Combination; Humans; Malaria; Mefloquine; Naphthoquinones; Plasmodium falciparum; Plasmodium vivax; Primaquine; Proguanil; Pyrimethamine; Risk Assessment	1998
Atovaquone-proguanil for falciparum malaria in the Philippines. The Journal of infectious diseases, 2000, Volume: 181, Issue:1 Topics: Antimalarials; Atovaquone; Chloroquine; Drug Combinations; Humans; Malaria, Falciparum; Naphthoquinones; Philippines; Proguanil; Pyrimethamine; Sulfadoxine	2000
In vitro quantitative analysis of (3)H-uracil incorporation by Sarcocytis neurona to determine efficacy of anti-protozoal agents. Veterinary parasitology, 2001, Feb-26, Volume: 95, Issue:2-4 Topics: Animals; Antiprotozoal Agents; Atovaquone; Cattle; Deer; DNA Replication; Glycine; Glyphosate; Herbicides; Male; Naphthoquinones; Nitriles; Pyrimethamine; Reproduction; Sarcocystis; Sulfadiazine; Sulfamethoxazole; Tetracycline; Triazines; Tritium; Uracil	2001
Opportunistic infections studies update. NIAID AIDS agenda, 1995,Spring Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Antitubercular Agents; Atovaquone; Candidiasis; Clinical Trials as Topic; Cryptosporidiosis; Cytomegalovirus; Cytomegalovirus Infections; Ganciclovir; Humans; Immunotherapy; Mycobacterium avium-intracellulare Infection; Naphthoquinones; Paromomycin; Pneumonia, Pneumocystis; Pyrimethamine; Toxoplasmosis; Tuberculosis	1995
Time of treatment influences the appearance of drug-resistant parasites in Plasmodium falciparum infections. Parasitology, 2001, Volume: 123, Issue:Pt 6 Topics: Animals; Antibodies, Protozoan; Antimalarials; Atovaquone; Computer Simulation; Drug Resistance; Humans; Malaria, Falciparum; Models, Biological; Mutation; Naphthoquinones; Plasmodium falciparum; Protozoan Proteins; Pyrimethamine; Time Factors	2001
Biguanide-atovaquone synergy against Plasmodium falciparum in vitro. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:8 Topics: Animals; Anti-Bacterial Agents; Antimalarials; Atovaquone; Biguanides; Drug Combinations; Drug Interactions; Naphthoquinones; Plasmodium falciparum; Pyrimethamine; Tetracyclines; Triazines	2002
[Blackwater fever]. Presse medicale (Paris, France : 1983), 2002, Sep-07, Volume: 31, Issue:28 Topics: Adolescent; Adult; Aged; Antimalarials; Atovaquone; Blackwater Fever; Critical Care; Diagnosis, Differential; Drug Combinations; Humans; Mefloquine; Middle Aged; Naphthoquinones; Phenanthrenes; Prognosis; Proguanil; Pyrimethamine; Quinine; Sulfadoxine	2002
Diagnosis and treatment of malaria in children. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, Nov-15, Volume: 37, Issue:10 Topics: Animals; Antimalarials; Atovaquone; Child; Chloroquine; Drug Combinations; Humans; Malaria; Malaria, Falciparum; Mefloquine; Naphthoquinones; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine	2003
Short communication: Prevalence of mutations associated with resistance to atovaquone and to the antifolate effect of proguanil in Plasmodium falciparum isolates from northern Ghana. Tropical medicine & international health : TM & IH, 2004, Volume: 9, Issue:3 Topics: Animals; Antimalarials; Atovaquone; Child, Preschool; Cytochromes b; Drug Combinations; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Folic Acid Antagonists; Ghana; Humans; Infant; Malaria, Falciparum; Male; Mutation; Naphthoquinones; Plasmodium falciparum; Polymorphism, Restriction Fragment Length; Proguanil; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Triazines	2004
Atovaquone maintenance therapy prevents reactivation of toxoplasmic encephalitis in a murine model of reactivated toxoplasmosis. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:12 Topics: Animals; Antiprotozoal Agents; Atovaquone; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Female; Injections, Intravenous; Liver; Lung; Mass Spectrometry; Meninges; Mice; Mice, Inbred C57BL; Naphthoquinones; Pyrimethamine; Sulfadiazine; Survival Analysis; Toxoplasmosis, Cerebral	2004
Plasmodium falciparum: interaction of shikimate analogues with antimalarial drugs. Experimental parasitology, 2005, Volume: 111, Issue:3 Topics: Animals; Antimalarials; Atovaquone; Drug Interactions; Naphthoquinones; Plasmodium falciparum; Proguanil; Pyrimethamine; Shikimic Acid; Triazines	2005
In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models. Experimental parasitology, 2007, Volume: 115, Issue:3 Topics: Animals; Antimalarials; Artemether; Artemisinins; Atovaquone; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Erythrocytes; Female; Heterocyclic Compounds, 1-Ring; Humans; Malaria; Mice; Parasitemia; Parasitic Sensitivity Tests; Peroxides; Plasmodium berghei; Plasmodium falciparum; Pyrimethamine; Quinolines; Spiro Compounds	2007
Adverse drug reactions to treatments for ocular toxoplasmosis: a retrospective chart review. Clinical therapeutics, 2008, Volume: 30, Issue:11 Topics: Adolescent; Adult; Atovaquone; Clindamycin; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Exanthema; Female; Gastrointestinal Diseases; Humans; Male; Medical Records; Middle Aged; Pyrimethamine; Retrospective Studies; Sulfadiazine; Sulfamethoxazole; Toxoplasmosis, Ocular; Trimethoprim; Vitreous Body; Young Adult	2008
Novel pfdhps haplotypes among imported cases of Plasmodium falciparum malaria in the United Kingdom. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:8 Topics: Adult; Alleles; Amino Acid Sequence; Animals; Antimalarials; Atovaquone; Chloroquine; Dihydropteroate Synthase; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Haplotypes; Humans; Malaria, Falciparum; Male; Plasmodium falciparum; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Sequence Analysis, DNA; Sulfadoxine; Tetrahydrofolate Dehydrogenase; United Kingdom	2009
Community management of anti-malarials in Africa and iatrogenic risk. Journal of tropical pediatrics, 2011, Volume: 57, Issue:3 Topics: Antimalarials; Atovaquone; Child; Community Health Services; Contraindications; Cote d'Ivoire; Diagnostic Errors; Drug Combinations; Female; Humans; Iatrogenic Disease; Liver Failure, Acute; Malaria; Proguanil; Pyrimethamine; Sulfadoxine	2011
Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials. Malaria journal, 2015, Jun-24, Volume: 14 Topics: Amodiaquine; Antimalarials; Atovaquone; Chloroquine; Colorimetry; Heme; Plasmodium falciparum; Pyrimethamine; Trophozoites	2015
Within-Host Selection of Drug Resistance in a Mouse Model of Repeated Incomplete Malaria Treatment: Comparison between Atovaquone and Pyrimethamine. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:1 Topics: Amino Acid Substitution; Animals; Antimalarials; Atovaquone; Cell Nucleus; Cytochromes b; Drug Resistance; Gene Expression; Host-Parasite Interactions; Malaria; Mice; Mice, Inbred BALB C; Mitochondria; Mutation Rate; Parasitic Sensitivity Tests; Plasmodium berghei; Protozoan Proteins; Pyrimethamine; Selection, Genetic; Tetrahydrofolate Dehydrogenase; Treatment Failure	2016
The Malaria TaqMan Array Card Includes 87 Assays for Plasmodium falciparum Drug Resistance, Identification of Species, and Genotyping in a Single Reaction. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:5 Topics: Antimalarials; Artemisinins; Atovaquone; Chloroquine; Drug Resistance; Epidemiological Monitoring; Genotyping Techniques; Humans; Malaria, Falciparum; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Pyrimethamine; Reagent Kits, Diagnostic; Sulfadoxine	2017
The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold. Journal of medicinal chemistry, 2017, 08-24, Volume: 60, Issue:16 Topics: 2,2'-Dipyridyl; Animals; Antimalarials; Atovaquone; Chloroquine; Drug Design; Female; Humans; Hydrazines; Mice; Mutagenicity Tests; Mutagens; Oxadiazoles; Parasitemia; Plasmodium falciparum; Pyrimethamine; Structure-Activity Relationship	2017
Development of an in vitro system to study the developmental stages of Toxoplasma gondii using a genetically modified strain expressing markers for tachyzoites and bradyzoites. Parasitology research, 2019, Volume: 118, Issue:12 Topics: Antiprotozoal Agents; Atovaquone; Brazil; Cell Line; Genetic Markers; Green Fluorescent Proteins; Humans; Life Cycle Stages; Parasitology; Pyrimethamine; Toxoplasma; Toxoplasmosis, Congenital	2019