atorvastatin and y 27632

Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

Topics: Amides; Atorvastatin; Cell Division; Cells, Cultured; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Mevalonic Acid; Peptidyl-Dipeptidase A; Phosphorylation; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; rho-Associated Kinases; RNA, Messenger; Sesquiterpenes; Umbilical Veins; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Amides; Analysis of Variance; Angiotensin II; Atorvastatin; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glucuronidase; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Tubules; Klotho Proteins; Membrane Proteins; Pyridines; Pyrroles; Quinolines; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; RNA, Messenger

Topics: Amides; Aorta; Atorvastatin; Bacterial Proteins; Bacterial Toxins; Butadienes; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Drug Synergism; Flavonoids; Group II Phospholipases A2; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-gamma; Janus Kinase 2; Lovastatin; Myocytes, Smooth Muscle; NF-kappa B; Nitriles; Phospholipases A; Phospholipases A2; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Pyrroles; RNA Stability; Up-Regulation

Topics: 3T3-L1 Cells; Adaptor Proteins, Signal Transducing; Adipocytes; ADP Ribose Transferases; Amides; Animals; Atorvastatin; Botulinum Toxins; Dose-Response Relationship, Drug; Glucose; Glucose Transporter Type 4; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Mice; Phosphorylation; Polyisoprenyl Phosphates; Pravastatin; Protein Kinase Inhibitors; Protein Prenylation; Protein Transport; Proto-Oncogene Proteins c-akt; Pyridines; Pyrroles; rab4 GTP-Binding Proteins; Receptor, Insulin; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction

Topics: Actins; Amides; Animals; Aorta; Atorvastatin; Blotting, Western; Cell Line; Enzyme Inhibitors; Gene Expression Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Microfilament Proteins; Muscle Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Proteins; Polyisoprenyl Phosphates; Potassium Chloride; Pyridines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; Trans-Activators; Vasoconstriction

Topics: Actin Depolymerizing Factors; Amides; Animals; Atorvastatin; Binding Sites; Cerebral Hemorrhage; Databases, Chemical; Databases, Protein; Disease Models, Animal; Enzyme Activation; Human Umbilical Vein Endothelial Cells; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Phosphorylation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyridines; Pyrroles; rho-Associated Kinases; Signal Transduction; Structure-Activity Relationship; Zebrafish

Topics: Amides; Animals; Aorta, Thoracic; Atorvastatin; Endothelin-1; Endothelium; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Norepinephrine; Phosphorylation; Polyisoprenyl Phosphates; Potassium Chloride; Prenylation; Protein Phosphatase 1; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Sesquiterpenes

Topics: 3T3-L1 Cells; Acetyltransferases; Adipocytes; Amides; Animals; Atorvastatin; Cell Survival; Delta-5 Fatty Acid Desaturase; Fatty Acid Desaturases; Fatty Acid Elongases; Gene Expression Regulation, Enzymologic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Polyisoprenyl Phosphates; Pyridines; rho-Associated Kinases; Signal Transduction

Topics: Amides; Atorvastatin; Cell Survival; Delta-5 Fatty Acid Desaturase; Dose-Response Relationship, Drug; Eicosanoic Acids; Fatty Acid Desaturases; Fatty Acid Elongases; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Humans; Mevalonic Acid; Polyisoprenyl Phosphates; Pyridines; rho-Associated Kinases; Signal Transduction; Up-Regulation

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Atorvastatin; Muscle Relaxants, Central; Perfusion; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasodilation; Vasodilator Agents

Topics: Animals; Atorvastatin; Cardiomyopathies; Chagas Disease; Cytokines; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Macrophages; Mice; NF-kappa B; rho-Associated Kinases; Trypanosoma cruzi; U937 Cells