Compounds > atorvastatin
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atorvastatin and sildenafil citrate

atorvastatin has been researched along with sildenafil citrate in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (57.14)29.6817
2010's6 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bendhack, LM; Castro, MM; Nagassaki, S; Rascado, RR; Rizzi, E; Tanus-Santos, JE1
Atar, S; Birnbaum, Y; Freeberg, SY; Huang, MH; Rahman, AM; Rosanio, S; Uretsky, BF; Ye, Y1
Bradbury, D; Herrmann, HC; Kimmel, SE; Levine, LA; Macaluso, J; Mohler, ER; Schwartz, S; Walsh, M1
Kukreja, RC1
Bank, AJ; Billups, KL; Crawford, WW; Kaiser, DR; Kelly, AS; Schow, DA; Waxman, B1
Byun, SS; Han, BK; Hong, SK; Jeong, SJ; Lee, SE1
Gokkaya, SC; Guzel, O; Hakan Koyuncu, H; Levent Ozdal, O; Memis, A; Ozden, C1
Chavalmane, AK; Fibbi, B; Filippi, S; Forti, G; Maggi, M; Morelli, A; Sarchielli, E; Silvestrini, E; Vannelli, GB; Vignozzi, L; Zhang, XH1
Archimandritis, A; Frenzilli, G; Peluso, C; Rocco, L; Stingo, V; Zito, G1
Czaikoski, PG; Dias-Junior, CA; Neto-Neves, EM; Pereira, RP; Spiller, F; Tanus-Santos, JE; Uzuelli, JA1
Waeber, C; Wang, QM; Wei, Y; Zheng, Y1
Ceron, CS; Gerlach, RF; Guimarães, DA; Pinheiro, LC; Rizzi, E; Tanus-Santos, JE1
Ceron, CS; Gerlach, RF; Guimarães, DA; Martins-Oliveira, A; Rizzi, E; Shiva, S; Tanus-Santos, JE1
Gerlach, RF; Guimaraes, DA; Meschiari, CA; Pinheiro, LC; Tanus-Santos, JE1

Trials

3 trial(s) available for atorvastatin and sildenafil citrate

ArticleYear
Can atorvastatin improve the response to sildenafil in men with erectile dysfunction not initially responsive to sildenafil? Hypothesis and pilot trial results.
    The journal of sexual medicine, 2006, Volume: 3, Issue:2

    Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Erectile Dysfunction; Heptanoic Acids; Humans; Male; Middle Aged; Penile Erection; Pilot Projects; Piperazines; Purines; Pyrroles; Sildenafil Citrate; Sulfones; Treatment Outcome

2006
The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction.
    Vascular medicine (London, England), 2006, Volume: 11, Issue:4

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Atorvastatin; Double-Blind Method; Drug Therapy, Combination; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Impotence, Vasculogenic; Male; Middle Aged; Phosphodiesterase Inhibitors; Piperazines; Purines; Pyrroles; Quinapril; Sildenafil Citrate; Sulfones; Surveys and Questionnaires; Tetrahydroisoquinolines; Time Factors; Treatment Failure; Treatment Outcome

2006
Effect of statin therapy on early return of potency after nerve sparing radical retropubic prostatectomy.
    The Journal of urology, 2007, Volume: 178, Issue:2

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Aged; Atorvastatin; Cyclic Nucleotide Phosphodiesterases, Type 5; Denervation; Drug Therapy, Combination; Erectile Dysfunction; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Microsurgery; Middle Aged; Penile Erection; Peripheral Nerves; Piperazines; Postoperative Complications; Prospective Studies; Prostate; Prostatectomy; Prostatic Neoplasms; Purines; Pyrroles; Sildenafil Citrate; Sulfones; Vasodilator Agents

2007

Other Studies

11 other study(ies) available for atorvastatin and sildenafil citrate

ArticleYear
Atorvastatin enhances sildenafil-induced vasodilation through nitric oxide-mediated mechanisms.
    European journal of pharmacology, 2004, Sep-13, Volume: 498, Issue:1-3

    Topics: Analysis of Variance; Animals; Anticholesteremic Agents; Aorta, Thoracic; Atorvastatin; Blood Pressure; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heptanoic Acids; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Acid; Nitric Oxide Synthase; Nitrites; Piperazines; Purines; Pyrroles; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents

2004
Enhanced cardioprotection against ischemia-reperfusion injury with combining sildenafil with low-dose atorvastatin.
    Cardiovascular drugs and therapy, 2006, Volume: 20, Issue:1

    Topics: Amidines; Animals; Atorvastatin; Benzylamines; Cardiotonic Agents; Drug Synergism; Heart; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phosphodiesterase Inhibitors; Phosphorylation; Piperazines; Purines; Pyrroles; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Up-Regulation

2006
Synergistic effects of atorvastatin and sildenafil in cardioprotection--role of NO.
    Cardiovascular drugs and therapy, 2006, Volume: 20, Issue:1

    Topics: Animals; Atorvastatin; Cardiotonic Agents; Drug Synergism; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Reperfusion Injury; Nitric Oxide; Phosphodiesterase Inhibitors; Piperazines; Purines; Pyrroles; Sildenafil Citrate; Sulfones

2006
Effect of correcting serum cholesterol levels on erectile function in patients with vasculogenic erectile dysfunction.
    Scandinavian journal of urology and nephrology, 2008, Volume: 42, Issue:5

    Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; Cholesterol; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Heptanoic Acids; Humans; Hypercholesterolemia; Impotence, Vasculogenic; Male; Middle Aged; Penile Erection; Phosphodiesterase Inhibitors; Piperazines; Purines; Pyrroles; Sildenafil Citrate; Sulfones; Ultrasonography, Doppler, Duplex

2008
Atorvastatin ameliorates sildenafil-induced penile erections in experimental diabetes by inhibiting diabetes-induced RhoA/Rho-kinase signaling hyperactivation.
    The journal of sexual medicine, 2009, Volume: 6, Issue:1

    Topics: Animals; Atorvastatin; Diabetes Mellitus, Experimental; Disease Models, Animal; Electric Stimulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Penile Erection; Phosphodiesterase Inhibitors; Phosphorylation; Piperazines; Purines; Pyrroles; Rabbits; rho-Associated Kinases; Signal Transduction; Sildenafil Citrate; Sulfones

2009
Genotoxic effects in fish induced by pharmacological agents present in the sewage of some Italian water-treatment plants.
    Environmental toxicology, 2012, Volume: 27, Issue:1

    Topics: Animals; Anticholesteremic Agents; Atorvastatin; Comet Assay; DNA Damage; Environmental Monitoring; Gemfibrozil; Heptanoic Acids; Hypolipidemic Agents; Italy; Mutagens; Piperazines; Purines; Pyrroles; Random Amplified Polymorphic DNA Technique; Sewage; Sildenafil Citrate; Sulfones; Vasodilator Agents; Waste Disposal, Fluid; Water Pollutants, Chemical; Zebrafish

2012
Sildenafil improves the beneficial hemodynamic effects exerted by atorvastatin during acute pulmonary thromboembolism.
    European journal of pharmacology, 2011, Nov-30, Volume: 670, Issue:2-3

    Topics: Acute Disease; Animals; Atorvastatin; Bronchoalveolar Lavage; Drug Synergism; Enzyme Activation; Heart Ventricles; Hemodynamics; Heptanoic Acids; Lipid Peroxidation; Lung; Male; Matrix Metalloproteinases; Myocytes, Cardiac; Neutrophils; Oxidative Stress; Piperazines; Pulmonary Embolism; Purines; Pyrroles; Sildenafil Citrate; Sulfones

2011
Efficacy of combined atorvastatin and sildenafil in promoting recovery after ischemic stroke in mice.
    American journal of physical medicine & rehabilitation, 2013, Volume: 92, Issue:2

    Topics: Animals; Atorvastatin; Behavior, Animal; Drug Therapy, Combination; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Neuropsychological Tests; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Pyrroles; Recovery of Function; Sildenafil Citrate; Stroke; Sulfones

2013
Atorvastatin and sildenafil lower blood pressure and improve endothelial dysfunction, but only atorvastatin increases vascular stores of nitric oxide in hypertension.
    Redox biology, 2013, Volume: 1

    Topics: Animals; Aorta; Atorvastatin; Blood Pressure; Body Weight; Disease Models, Animal; Drug Therapy, Combination; Heptanoic Acids; Hypertension, Renovascular; Male; Nitric Oxide; Piperazines; Purines; Pyrroles; Rats; Rats, Wistar; Sildenafil Citrate; Sulfonamides

2013
Atorvastatin and sildenafil decrease vascular TGF-β levels and MMP-2 activity and ameliorate arterial remodeling in a model of renovascular hypertension.
    Redox biology, 2015, Volume: 6

    Topics: Animals; Aorta; Atorvastatin; Cardiovascular Agents; Collagen; Disease Models, Animal; Drug Combinations; Drug Synergism; Endothelium, Vascular; Gene Expression Regulation; Hypertension, Renovascular; Male; Matrix Metalloproteinase 2; Myocytes, Smooth Muscle; Oxidative Stress; Platelet-Derived Growth Factor; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Sildenafil Citrate; Transforming Growth Factor beta; Vascular Remodeling

2015
Sodium nitrite attenuates MMP-9 production by endothelial cells and may explain similar effects of atorvastatin.
    Naunyn-Schmiedeberg's archives of pharmacology, 2016, Volume: 389, Issue:2

    Topics: Atorvastatin; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Down-Regulation; Human Umbilical Vein Endothelial Cells; Humans; Matrix Metalloproteinase 9; Nitric Oxide; Phosphodiesterase 5 Inhibitors; Phosphorylation; Signal Transduction; Sildenafil Citrate; Sodium Nitrite; Tetradecanoylphorbol Acetate; Transcription Factor RelA

2016