Page last updated: 2024-08-24

atorvastatin and endothelin-1

atorvastatin has been researched along with endothelin-1 in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.55)18.2507
2000's6 (27.27)29.6817
2010's13 (59.09)24.3611
2020's2 (9.09)2.80

Authors

AuthorsStudies
Díaz, C; Hernández, G; Hernández-Perera, O; Lamas, S; Navarro-Antolín, J; Pérez-Sala, D; Sánchez-Pascuala, R1
Dixon, JL; Katwa, LC; Lee, DL; Reddy, HK; Sturek, M; Voelker, DJ; Wamhoff, BR1
Lawler, RL; Letterer, RA; Levy, WC; McDonald, GB; Minami, E; Mozaffarian, D1
Hayashi, T; Ka, Y; Kitamura, A; Matsumura, Y; Mori, T; Ohkita, M; Sugii, M; Takaoka, M1
Chu, CH; Chuang, MJ; Keng, HM; Lam, HC; Lee, JK; Lu, CC; Sun, CC; Tai, MH; Wang, MC; Wei, MC1
Hirano, H; Morishita, T; Nakashima, Y; Nakata, S; Ozumi, K; Sabanai, K; Sasaguri, Y; Shimokawa, H; Suda, O; Tanimoto, A; Tasaki, H; Tsutsui, M; Yamashita, T; Yanagihara, N1
Antonini, R; Antonini, TM; Arca, M; Fraioli, A; Letizia, C; Luigi, P; Maddaloni, M; Mastrantoni, M; Montali, A; Pigna, G1
Chang, CZ; Howng, SL; Hwang, SL; Kwan, AL; Lin, CL; Wu, SC1
Jiang, R; Kan, H; Song, W; Xie, Y; Zhao, J1
Alaminos, M; Esteban, M; Garrido, JM; Roda, O; Sánchez-Montesinos, I1
Li, T; Liu, J; Sai, X; Sun, Y; Wang, D; Yang, B; Zhou, R1
Alarcón-Galván, G; Cámara-Lemarroy, CR; Cordero-Pérez, P; Fernández-Garza, NE; Guzmán-de la Garza, FJ; Muñoz-Espinosa, L; Torres-González, L1
Abdallah, MA; Asker, Mel-S; Atteia, HH; El-Seweidy, MM; Eldahmy, SI1
Alp Yildirim, Fİ; Ark, M; Aypar, E; Kaleli Durman, D; Özdemir, O; Uydeş Doğan, BS1
Chen, JH; Chen, L; Jiang, BJ; Li, PP; Wang, YH; Wu, Y; Yang, LK; Zhu, J1
Chen, H; Kong, J; Li, J; Yang, O1
Chen, JH; Chen, L; Hu, X; Li, PP; Wang, YH; Wu, T; Yang, LK; Zhu, J1
Baydoun, D; Ibdah, R; Ibrahim, K; Mayyas, F1
Fei, MY; Hu, GP; Liu, ZJ; Shi, QX; Sun, F; Yin, Z1
Fang, T; Guo, B; Wang, L; Xue, L1
Gong, S; Gu, A; Qin, S; Wu, Z; Xue, J1
Augustin, S; Barberá, A; Bravo, M; Estrella, F; Genescà, J; Gil, M; Hide, D; Martell, M; Raurell, I; Salcedo, MT1

Trials

5 trial(s) available for atorvastatin and endothelin-1

ArticleYear
The effects of atorvastatin (10 mg) on systemic inflammation in heart failure.
    The American journal of cardiology, 2005, Dec-15, Volume: 96, Issue:12

    Topics: Adult; Aged; Atorvastatin; Biomarkers; C-Reactive Protein; Cross-Over Studies; Double-Blind Method; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Female; Heart Failure; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Middle Aged; Pyrroles; Receptors, Tumor Necrosis Factor, Type I; Treatment Outcome

2005
The effects of different doses of atorvastatin on plasma endothelin-1 levels in type 2 diabetic patients with dyslipidemia.
    Experimental biology and medicine (Maywood, N.J.), 2006, Volume: 231, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Atorvastatin; Cholesterol; Cholesterol, LDL; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Dyslipidemias; Endothelin-1; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Male; Middle Aged; Pyrroles

2006
Comparison of atorvastatin versus fenofibrate in reaching lipid targets and influencing biomarkers of endothelial damage in patients with familial combined hyperlipidemia.
    Metabolism: clinical and experimental, 2007, Volume: 56, Issue:11

    Topics: Adult; Aged; Atorvastatin; Biomarkers; Endothelin-1; Endothelium, Vascular; Female; Fenofibrate; Heptanoic Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Pyrroles

2007
Effects of Short-term High Dose Atorvastatin on Left Ventricular Remodeling in Patients with First Time Attack of Anterior Acute Myocardial Infarction.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2018, Jun-30, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Aged; Atorvastatin; C-Reactive Protein; Drug Administration Schedule; Echocardiography; Endothelin-1; Female; Humans; Male; Malondialdehyde; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Middle Aged; Myocardial Infarction; Ventricular Function, Left; Ventricular Remodeling; Young Adult

2018
High-dose atorvastatin improves vascular endothelial function in patients with leukoaraiosis.
    Journal of clinical laboratory analysis, 2020, Volume: 34, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Atorvastatin; C-Reactive Protein; Case-Control Studies; Cholesterol; Cholesterol, LDL; Dose-Response Relationship, Drug; Endothelin-1; Endothelium, Vascular; Female; Humans; Latex Fixation Tests; Leukoaraiosis; Magnetic Resonance Imaging; Male; Middle Aged; Nitric Oxide

2020

Other Studies

17 other study(ies) available for atorvastatin and endothelin-1

ArticleYear
Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells.
    The Journal of clinical investigation, 1998, Jun-15, Volume: 101, Issue:12

    Topics: Animals; Atorvastatin; Cattle; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pyrroles; RNA, Messenger; Simvastatin

1998
Increased endothelin-induced Ca2+ signaling, tyrosine phosphorylation, and coronary artery disease in diabetic dyslipidemic Swine are prevented by atorvastatin.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:1

    Topics: Animals; Anticholesteremic Agents; Atorvastatin; Calcium; Calcium Signaling; Coronary Artery Disease; Diabetes Complications; Diet; Disease Models, Animal; Endothelin-1; Endothelins; Heptanoic Acids; Hyperlipidemias; Male; Phosphorylation; Pyrroles; Receptor, Endothelin A; Receptors, Endothelin; Swine; Tyrosine

2003
Differential effects of different statins on endothelin-1 gene expression and endothelial NOS phosphorylation in porcine aortic endothelial cells.
    Experimental biology and medicine (Maywood, N.J.), 2006, Volume: 231, Issue:6

    Topics: Animals; Aorta; Atorvastatin; Cells, Cultured; Endothelial Cells; Endothelin-1; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide Synthase Type III; Phosphorylation; Pravastatin; Pyridines; Pyrroles; Quinolines; RNA, Messenger; Swine

2006
Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway.
    Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:1

    Topics: Angiotensin II; Animals; Atorvastatin; Cells, Cultured; Endothelin-1; Gene Expression Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oncogene Protein v-akt; Pyrroles; Rats; Rats, Sprague-Dawley; Up-Regulation

2007
Atorvastatin preconditioning attenuates the production of endothelin-1 and prevents experimental vasospasm in rats.
    Acta neurochirurgica, 2010, Volume: 152, Issue:8

    Topics: Animals; Atorvastatin; Disease Models, Animal; Endothelin-1; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Preconditioning; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrroles; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Treatment Outcome; Vasodilation; Vasospasm, Intracranial

2010
Effects of atorvastatin on fine particle-induced inflammatory response, oxidative stress and endothelial function in human umbilical vein endothelial cells.
    Human & experimental toxicology, 2011, Volume: 30, Issue:11

    Topics: Air Pollutants; Anti-Inflammatory Agents; Atorvastatin; Cell Survival; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Malondialdehyde; Nitric Oxide; Oxidative Stress; P-Selectin; Particulate Matter; Pyrroles; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2011
Lysophosphatidic acid pretreatment prevents micromolar atorvastatin-induced endothelial cell death and ensures the beneficial effects of high-concentration statin therapy on endothelial gene expression.
    Annals of vascular surgery, 2012, Volume: 26, Issue:4

    Topics: Apoptosis; Atorvastatin; Cell Death; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Gene Expression Regulation; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lysophospholipids; Nitric Oxide Synthase Type III; Oligonucleotide Array Sequence Analysis; Pyrroles; RNA

2012
Inhibitory effect of co-administration of atorvastatin and endothelin-1 receptor antagonist on the progression of atherosclerosis in rabbit.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2014, Volume: 122, Issue:6

    Topics: Animals; Aorta, Abdominal; Atherosclerosis; Atorvastatin; Diet, High-Fat; Disease Models, Animal; Disease Progression; Down-Regulation; Drug Synergism; Drug Therapy, Combination; Endothelin A Receptor Antagonists; Endothelin-1; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Iliac Artery; Inflammation Mediators; Lipids; Male; Matrix Metalloproteinase 9; NF-kappa B; Phenylpropionates; Plaque, Atherosclerotic; Pyrimidines; Pyrroles; Rabbits; RNA, Messenger

2014
Hepatic ischemia/reperfusion injury is diminished by atorvastatin in Wistar rats.
    Archives of medical research, 2014, Volume: 45, Issue:3

    Topics: Animals; Antithrombin III; Atorvastatin; Endothelin-1; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intercellular Adhesion Molecule-1; Liver; Male; Pyrroles; Rats, Wistar; Reperfusion Injury; Tumor Necrosis Factor-alpha

2014
Haemostatic risk factors in dyslipidemic rabbits: role of 10-dehydrogingerdione as a new hypolipemic agent.
    Journal of thrombosis and thrombolysis, 2015, Volume: 39, Issue:2

    Topics: Animals; Anticholesteremic Agents; Atherosclerosis; Atorvastatin; Blood Coagulation; Cholesterol Ester Transfer Proteins; Disease Models, Animal; Dyslipidemias; Endothelin-1; Endothelium, Vascular; Guaiacol; Nitric Oxide; Plasminogen Activator Inhibitor 1; Rabbits; Treatment Outcome

2015
Atorvastatin acutely reduces the reactivity to spasmogens in rat aorta: implication of the inhibition of geranylgeranylation and MYPT-1 phosphorylation.
    Fundamental & clinical pharmacology, 2016, Volume: 30, Issue:2

    Topics: Amides; Animals; Aorta, Thoracic; Atorvastatin; Endothelin-1; Endothelium; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Norepinephrine; Phosphorylation; Polyisoprenyl Phosphates; Potassium Chloride; Prenylation; Protein Phosphatase 1; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; Sesquiterpenes

2016
Atorvastatin ameliorates early brain injury after subarachnoid hemorrhage via inhibition of AQP4 expression in rabbits.
    International journal of molecular medicine, 2016, Volume: 37, Issue:4

    Topics: Animals; Apoptosis; Aquaporin 4; Atorvastatin; Brain; Brain Edema; Brain Injuries; Caspase 3; Endothelin-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuroprotective Agents; Rabbits; Subarachnoid Hemorrhage; Water

2016
Atorvastatin ameliorates endothelium-specific insulin resistance induced by high glucose combined with high insulin.
    Molecular medicine reports, 2016, Volume: 14, Issue:3

    Topics: Atorvastatin; Endothelin-1; Endothelium, Vascular; Enzyme Activation; Gene Expression; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin Resistance; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; RNA, Messenger; Signal Transduction

2016
Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage.
    Molecular medicine reports, 2018, Volume: 17, Issue:1

    Topics: Animals; Anticholesteremic Agents; Apoptosis; Atorvastatin; Basilar Artery; Brain; Endothelin-1; Male; Neurons; Protective Agents; Rabbits; Subarachnoid Hemorrhage; Vasospasm, Intracranial

2018
Atorvastatin Reduces Plasma Inflammatory and Oxidant Biomarkers in Patients With Risk of Atherosclerotic Cardiovascular Disease.
    Journal of cardiovascular pharmacology and therapeutics, 2018, Volume: 23, Issue:3

    Topics: Adult; Aged; Atherosclerosis; Atorvastatin; C-Reactive Protein; Dose-Response Relationship, Drug; Endothelin-1; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lipids; Male; Middle Aged; Oxidants; Oxidative Stress; Peroxidase; Prospective Studies; Risk Factors; Superoxide Dismutase

2018
Atorvastatin Prevents Myocardial Fibrosis in Spontaneous Hypertension via Interleukin-6 (IL-6)/Signal Transducer and Activator of Transcription 3 (STAT3)/Endothelin-1 (ET-1) Pathway.
    Medical science monitor : international medical journal of experimental and clinical research, 2019, Jan-11, Volume: 25

    Topics: Animals; Atorvastatin; Blood Pressure; Cardiomyopathies; Disease Models, Animal; Endomyocardial Fibrosis; Endothelin-1; Fibrosis; Hypertension; Interleukin-6; Male; Myocardium; Phosphorylation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; STAT3 Transcription Factor

2019
Synergic effect of atorvastatin and ambrisentan on sinusoidal and hemodynamic alterations in a rat model of NASH.
    Disease models & mechanisms, 2021, 05-01, Volume: 14, Issue:5

    Topics: Alanine Transaminase; Animals; Atorvastatin; Biomarkers; Collagen; Disease Models, Animal; Drug Synergism; Endothelial Cells; Endothelin-1; Enzyme Activation; Hemodynamics; Hepatic Stellate Cells; Insulin Resistance; Liver; Liver Cirrhosis; Nitric Oxide Synthase Type III; Non-alcoholic Fatty Liver Disease; Phenylpropionates; Pyridazines; Weight Gain

2021