Page last updated: 2024-08-24

atorvastatin and cerivastatin

atorvastatin has been researched along with cerivastatin in 82 studies

Research

Studies (82)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (4.88)	18.2507
2000's	70 (85.37)	29.6817
2010's	7 (8.54)	24.3611
2020's	1 (1.22)	2.80

Authors

Authors	Studies
Buckett, L; Davidson, R; Holdgate, G; McCormick, A; McTaggart, F; Schneck, D; Smith, G; Warwick, M	1
Aparna, V; Chakraborti, AK; Gopalakrishnan, B; Kumar, R; Sobhia, ME; Thilagavathi, R	1
Chiba, K; Hosokawa, M; Kameyama, Y; Kobayashi, K; Yamashita, K	1
Carbonell, T; Freire, E	1
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
Askew, V; Auerbach, B; Bainbridge, G; Caspers, N; Choi, C; Dillon, L; Hanselman, JC; Harris, MS; Hutchings, R; Kowala, M; Larsen, SD; Lin, Z; Lu, GH; Park, W; Pavlovsky, A; Pfefferkorn, JA; Robertson, A; Sekerke, C; Tait, BD	1
Askew, V; Auerbach, B; Dillon, L; Hanselman, JC; Kennedy, RM; Kowala, MC; Larsen, SD; Lin, Z; Lu, GH; Miller, S; Park, WK; Robertson, A; Roth, BD; Sekerke, C; Song, Y; Steinbaugh, BA; Sun, K; Tait, BD; Trivedi, BK	1
Ahmad, S; Barrish, JC; Bird, E; Bisaha, S; Blanar, MA; Chang, M; Chen, BC; Chen, X; Cuff, CA; Darienzo, CJ; Giancarli, M; Harrity, T; Huang, C; Janovitz, E; Kennedy, LJ; Li, T; Madsen, CS; Monshizadegan, H; Ngu, K; Nguyen-Tran, V; Reeves, RA; Robl, JA; Ryan, CS; Search, D; Setters, R; Sitkoff, D; Stein, PD; Yin, X; Zahler, R; Zhang, R; Zhao, R; Zhuang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Dalvie, D; Loi, CM; Smith, DA	1
Assang, C; Baillie, TA; Lin, JH; Lu, P; Ma, B; Meng, Y; Prueksaritanont, T; Reider, PJ; Tang, C	1
Farnier, M	1
Hoshi, K; Ichihara, K; Satoh, K; Yamamoto, A	1
Hecker, M; Just, I; Köhler, T; Rückschloss, U; Wagner, AH	1
Baetta, R; Bellosta, S; Bernini, F; Corsini, A; Fumagalli, R; Paoletti, R	1
Ichihara, K; Satoh, K	1
Arnaboldi, L; Bellosta, S; Bernini, F; Corsini, A; Ferri, N; Paoletti, R	1
Dansette, PM; Jaoen, M; Pons, C	1
Agarwal, V; Lasseter, KC; Lettieri, J; Mazzu, AL; Shamblen, EC; Sundaresen, P	1
Ose, L; Risberg, K; Svilaas, A; Thoresen, M	1
Davidson, MH	1
Stein, EA	1
Black, DM	1
Crouch, MA	1
Burkhardt, K; Hauser, IA; Koch, C; Mayer-Kadner, I; Renders, L; Schärffe, S; Schmieder, RE; Veelken, R	1
Lupattelli, G; Palumbo, B; Sinzinger, H	1
Maclaine, GD; Patel, H	1
Dimitroulakos, J; Minden, MD; Penn, LZ; Tan, MM; Wong, WW; Xia, Z	1
Breuer, HW	1
Wierzbicki, AS	1
Davidson, M; Hunninghake, D; Insull, W; Jones, P; Kafonek, S; Knopp, R; Lohrbauer, L	1
Igel, M; Sudhop, T; von Bergmann, K	1
Bazalo, GR	1
Bruegel, M; Stein, O; Stein, Y; Teupser, D; Thiery, J	1
Cooke, JP; Glassford, AJ; Heeschen, C; Weis, M	1
Baillie, TA; Fang, X; Lin, JH; Ma, B; Pearson, PG; Prueksaritanont, T; Qiu, Y; Subramanian, R	1
Auteri, A; Bova, G; Bruni, F; Cercignani, M; Console, E; Palazzuoli, A; Pasqui, AL; Puccetti, L	1
Hinman, J; Scanu, AM	1
Brandes, RP; Vecchione, C	1
Bavendiek, U; Ganz, P; Gerdes, N; Horton, DB; Kinlay, S; Libby, P; Reynolds, RS; Robbie, L; Schönbeck, U; Varo, N	1
Baghestanian, M; Bühring, HJ; Ghannadan, M; Hauswirth, AW; Majlesi, Y; Rezaie-Majd, A; Samorapoompichit, P; Schernthaner, GH; Sperr, WR; Valent, P; Valenta, R	1
Dechend, R; Dietz, R; Gieffers, J; Joerres, A; Luft, FC; Maass, M; Rupp, J	1
Fujino, H; Hirano, M; Kojima, J; Shimada, S; Tsunenari, Y; Yamada, I	1
Edwards, JE; Moore, RA	1
Fukuda, N; Nada, T; Sakabe, K; Shinohara, H; Tamura, Y; Wakayama, K	1
Bernier, L; Chamberland, A; Davignon, J; Dubuc, G; Prat, A; Seidah, NG; Wassef, H	1
Jono, S; Kizu, A; Koyama, H; Nishizawa, Y; Okuno, Y; Shioi, A	1
Ilkay Alp, F; Kaleli, D; Ozdemir, O; Sönmez Uydeş-Doğan, B; Takir, S; Topal, G	1
Delles, C; Jacobi, J; John, S; Schmieder, RE; Schneider, MP	1
Iwano, C; Matsuyama, K; Matzno, S; Nishikata, M; Yasuda, N	1
Hamakubo, T; Izumi, A; Kodama, T; Morikawa, S; Murakami, T; Saito, Y; Yamazaki, H	1
Corpataux, JM; London, NJ; Naik, J; Porter, KE	1
Dieleman, JP; Dunselman, H; Straus, SM; Sturkenboom, MC; van Herpen, G; van Wijk, MA; van Wyk, JT	1
Juman, S; Matsuyama, K; Matzno, S; Nagareya-Ishida, N; Nakabayashi, T; Tazuya-Murayama, K; Yamamoto, Y; Yasuda, S	1
Balice, M; Chironi, G; Del-Pino, M; Gariepy, J; Levenson, J; Simon, A	1
Jadhav, SB; Jain, GK	1
Baghestanian, M; Ghannadan, M; Hauswirth, AW; Krauth, MT; Majlesi, Y; Müller, MR; Samorapoompichit, P; Schernthaner, GH; Sonneck, K; Sperr, WR; Valent, P; Worda, C	1
Auberger, P; Bouvet, S; Fromigué, O; Haÿ, E; Jacquel, A; Marie, PJ; Modrowski, D	1
Foody, JM; Galusha, D; Havranek, EP; Krumholz, HM; Masoudi, FA; Radford, MJ; Rathore, SS	1
Hirano, T; Iseki, K; Itagaki, S; Kobayashi, M; Otsuka, Y	1
Hayashi, T; Ka, Y; Kitamura, A; Matsumura, Y; Mori, T; Ohkita, M; Sugii, M; Takaoka, M	1
Brecht, K; Kaufmann, P; Krähenbühl, S; Török, M; Waldhauser, KM; Zahno, A	1
Mason, RP	1
Hammervold, T; Howe, PR; Meyer, BJ; Rustan, AC	1
Iwano, C; Matsuyama, K; Matzno, S; Tomiyama, N; Yasuda, N	1
Dal Pan, G; McAdams, M; Staffa, J	1
Chen, X; Estey, C; Moon, TW	1
Brenner, H; Hahmann, H; Hoffmann, MM; Rothenbacher, D; Vossen, CY; Wüsten, B	1
Gardiner, P; Paine, SW; Parker, AJ; Riley, RJ; Webborn, PJ	1
Xiao, H; Yang, CS	1
Kromer, A; Moosmann, B	1
Antoine, JC; Estour, B; Germain, N; Khalfallah, Y; Leca, V; Vergely, N	1
Hohenegger, M; Minichsdorfer, C	1
Bate, A; Edwards, IR; Hägg, S; Strandell, J	1
Fuhrmeister, J; Kromer, A; Moosmann, B; Tews, M	1
Beckx, K; Dhar, M; Eyskens, F; Luyckx, E; Simons, A; Van West, D	1
Cheng, Z; Fu, SW; Hu, B; Ruan, LY; Wang, Y; Zheng, JN; Zheng, MH; Zhou, YY; Zhu, GQ	1
Adams, SP; Alaeiilkhchi, N; Wright, JM	1

Reviews

16 review(s) available for atorvastatin and cerivastatin

Article	Year
[The hyperlipidemias. Role of various statins]. Presse medicale (Paris, France : 1983), 1999, Nov-20, Volume: 28, Issue:36 Topics: Anticholesteremic Agents; Atorvastatin; Cardiovascular Diseases; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Lovastatin; Pravastatin; Pyridines; Pyrroles; Simvastatin	1999
New insights into the pharmacodynamic and pharmacokinetic properties of statins. Pharmacology & therapeutics, 1999, Volume: 84, Issue:3 Topics: Animals; Anticholesteremic Agents; Atorvastatin; Cell Division; Cytochrome P-450 Enzyme System; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Mevalonic Acid; Pyridines; Pyrroles; Simvastatin	1999
Statin trials in progress: unanswered questions. Current atherosclerosis reports, 2001, Volume: 3, Issue:1 Topics: Atorvastatin; Clinical Trials as Topic; Coronary Disease; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hypolipidemic Agents; Indoles; Lovastatin; Pravastatin; Pyridines; Pyrroles; Simvastatin	2001
New statins and new doses of older statins. Current atherosclerosis reports, 2001, Volume: 3, Issue:1 Topics: Atorvastatin; Cholesterol, LDL; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hypolipidemic Agents; Indoles; Lovastatin; Pravastatin; Pyridines; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides	2001
Statins in children: what do we know and what do we need to do? Current atherosclerosis reports, 2001, Volume: 3, Issue:1 Topics: Atorvastatin; Bezafibrate; Child; Child Welfare; Cost-Benefit Analysis; Drug Approval; Gemfibrozil; Heptanoic Acids; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Pyridines; Pyrroles; Simvastatin	2001
Effective use of statins to prevent coronary heart disease. American family physician, 2001, Jan-15, Volume: 63, Issue:2 Topics: Atorvastatin; Cholesterol, LDL; Coronary Disease; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Pravastatin; Pyridines; Pyrroles; Risk Factors; Simvastatin	2001
Statin therapy--what now? Drug and therapeutics bulletin, 2001, Volume: 39, Issue:3 Topics: Anticholesteremic Agents; Atorvastatin; Coronary Disease; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hyperlipidemias; Indoles; Patient Selection; Pravastatin; Pyridines; Pyrroles; Risk Factors; Simvastatin; Treatment Outcome	2001
Hypertriglyceridemia: a review of clinical relevance and treatment options: focus on cerivastatin. Current medical research and opinion, 2001, Volume: 17, Issue:1 Topics: Atorvastatin; Coronary Disease; Drug Therapy, Combination; Gemfibrozil; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Hypolipidemic Agents; Niacin; Pyridines; Pyrroles; Risk Factors; Triglycerides	2001
Synthetic statins: more data on newer lipid-lowering agents. Current medical research and opinion, 2001, Volume: 17, Issue:1 Topics: Arteriosclerosis; Atorvastatin; Clinical Trials as Topic; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Indoles; Lipids; Pyridines; Pyrroles; Simvastatin	2001
Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins). European journal of clinical pharmacology, 2001, Volume: 57, Issue:5 Topics: Atorvastatin; Drug Interactions; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Pravastatin; Pyridines; Pyrroles; Simvastatin	2001
Statins in hypercholesterolaemia: a dose-specific meta-analysis of lipid changes in randomised, double blind trials. BMC family practice, 2003, Dec-01, Volume: 4 Topics: Atorvastatin; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Pravastatin; Pyridines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Triglycerides	2003
Statins and osteoporosis: new role for old drugs. The Journal of pharmacy and pharmacology, 2006, Volume: 58, Issue:1 Topics: Animals; Atorvastatin; Bone and Bones; Clinical Trials as Topic; Drug Delivery Systems; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Fractures, Bone; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver; Lovastatin; Osteogenesis; Osteoporosis; Pharmacokinetics; Pravastatin; Pyridines; Pyrimidines; Pyrroles; Quinolines; Rosuvastatin Calcium; Simvastatin; Sulfonamides	2006
Molecular basis of differences among statins and a comparison with antioxidant vitamins. The American journal of cardiology, 2006, Dec-04, Volume: 98, Issue:11A Topics: Antioxidants; Atorvastatin; Cholesterol, LDL; Coronary Artery Disease; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Pyridines; Pyrroles; Vitamins	2006
Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention. International journal of cancer, 2008, Sep-01, Volume: 123, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Atorvastatin; Celecoxib; Colorectal Neoplasms; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Evidence-Based Medicine; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Meta-Analysis as Topic; Neoplasms; Pravastatin; Pyrazoles; Pyridines; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin; Sulfonamides; Sulindac	2008
Systematic review with network meta-analysis: statins and risk of hepatocellular carcinoma. Oncotarget, 2016, Apr-19, Volume: 7, Issue:16 Topics: Atorvastatin; Bayes Theorem; Carcinoma, Hepatocellular; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver; Liver Neoplasms; Lovastatin; Observational Studies as Topic; Pravastatin; Pyridines; Rosuvastatin Calcium; Simvastatin; Treatment Outcome	2016
Pitavastatin for lowering lipids. The Cochrane database of systematic reviews, 2020, 06-19, Volume: 6 Topics: Atorvastatin; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Controlled Before-After Studies; Drug Administration Schedule; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Pyridines; Quinolines; Randomized Controlled Trials as Topic; Rosuvastatin Calcium; Sex Factors; Triglycerides	2020

Trials

9 trial(s) available for atorvastatin and cerivastatin

Article	Year
Itraconazole alters the pharmacokinetics of atorvastatin to a greater extent than either cerivastatin or pravastatin. Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:4 Topics: Adult; Anticholesteremic Agents; Antifungal Agents; Area Under Curve; Atorvastatin; Cross-Over Studies; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Itraconazole; Male; Pravastatin; Pyridines; Pyrroles; Reference Values; Time Factors	2000
Efficacy and drug interactions of the new HMG-CoA reductase inhibitors cerivastatin and atorvastatin in CsA-treated renal transplant recipients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16, Issue:1 Topics: Adult; Aged; Atorvastatin; Cardiovascular Diseases; Cyclosporine; Drug Interactions; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypolipidemic Agents; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Pyridines; Pyrroles; Safety	2001
Comparison of the efficacy of atorvastatin versus cerivastatin in primary hypercholesterolemia. The American journal of cardiology, 2001, Sep-15, Volume: 88, Issue:6 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Apolipoproteins B; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Drug Administration Schedule; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Male; Middle Aged; Prospective Studies; Pyridines; Pyrroles; Treatment Outcome; Triglycerides; United States	2001
Effect of diet and treatment with statins on platelet-dependent thrombin generation in hypercholesterolemic subjects. Nutrition, metabolism, and cardiovascular diseases : NMCD, 2001, Volume: 11, Issue:6 Topics: Adult; Anticholesteremic Agents; Atorvastatin; Blood Platelets; Cholesterol; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hypercholesterolemia; Indoles; Male; Middle Aged; Pravastatin; Pyridines; Pyrroles; Simvastatin; Thrombin; Treatment Outcome	2001
Issues concerning the monitoring of statin therapy in hypercholesterolemic subjects with high plasma lipoprotein(a) levels. Lipids, 2002, Volume: 37, Issue:5 Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; Enzyme-Linked Immunosorbent Assay; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Lipoprotein(a); Lipoproteins, LDL; Male; Middle Aged; Pravastatin; Pyridines; Pyrroles; Simvastatin	2002
Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells. Circulation, 2002, Dec-03, Volume: 106, Issue:23 Topics: Animals; Atorvastatin; Blood Coagulation; CD40 Antigens; CD40 Ligand; Cells, Cultured; Cohort Studies; Coronary Stenosis; Cytokines; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocytes, Mononuclear; Lipoproteins, LDL; Male; Mice; Middle Aged; Muscle, Smooth, Vascular; Phagocytes; Pyridines; Pyrroles; RNA, Messenger; Simvastatin	2002
Time course differences for statin-induced pleiotropic effects in hypercholesterolemic patients. International journal of cardiology, 2004, Volume: 94, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Anticholesteremic Agents; Atorvastatin; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Lipoproteins; Male; Middle Aged; Mutation; Phenotype; Pyridines; Pyrroles; Time Factors	2004
Lipid-independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patients. American heart journal, 2005, Volume: 149, Issue:3 Topics: Acetylcholine; Adult; Aged; Ascorbic Acid; Atorvastatin; Biological Availability; C-Reactive Protein; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Female; Forearm; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipid Metabolism; Male; Middle Aged; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Pyridines; Pyrroles; Regional Blood Flow; Vasodilation	2005
Dose-dependent effects of docosahexaenoic acid supplementation on blood lipids in statin-treated hyperlipidaemic subjects. Lipids, 2007, Volume: 42, Issue:2 Topics: Animals; Apolipoproteins B; Atorvastatin; Cholesterol, LDL; Dietary Fats; Dietary Fats, Unsaturated; Dietary Supplements; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fish Oils; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Lipid Metabolism; Lipids; Lipoproteins, IDL; Lipoproteins, VLDL; Male; Middle Aged; Pyridines; Pyrroles; Simvastatin; Treatment Outcome; Triglycerides	2007

Other Studies

57 other study(ies) available for atorvastatin and cerivastatin

Article	Year
Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. The American journal of cardiology, 2001, Mar-08, Volume: 87, Issue:5A Topics: Animals; Arteriosclerosis; Cholesterol, LDL; Clinical Trials as Topic; Drug Evaluation, Preclinical; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Molecular Structure; Pyrimidines; Rosuvastatin Calcium; Sulfonamides	2001
Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA). Bioorganic & medicinal chemistry letters, 2005, Feb-15, Volume: 15, Issue:4 Topics: Binding Sites; Crystallography, X-Ray; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Inhibitory Concentration 50; Models, Molecular; Protein Conformation; Pyrroles; Quantitative Structure-Activity Relationship	2005
Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B15, SLCO1B115 and SLCO1B115+C1007G, by using transient expression systems of HeLa and HEK293 cells. Pharmacogenetics and genomics, 2005, Volume: 15, Issue:7* Topics: Alleles; Atorvastatin; Biological Transport; Cells, Cultured; Genetic Variation; HeLa Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Liver-Specific Organic Anion Transporter 1; Mutagenesis, Site-Directed; Organic Anion Transporters; Polymorphism, Single Nucleotide; Pravastatin; Pyridines; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Substrate Specificity; Transfection	2005
Binding thermodynamics of statins to HMG-CoA reductase. Biochemistry, 2005, Sep-06, Volume: 44, Issue:35 Topics: Atorvastatin; Binding Sites; Calorimetry; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Pravastatin; Protein Binding; Pyridines; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides; Thermodynamics	2005
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hyper Journal of medicinal chemistry, 2008, Jan-10, Volume: 51, Issue:1 Topics: Animals; Cholesterol, LDL; Cricetinae; Guinea Pigs; Hepatocytes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; In Vitro Techniques; Liver; Male; Mesocricetus; Muscle Cells; Pyrazoles; Rats; Stereoisomerism; Structure-Activity Relationship	2008
Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors. Bioorganic & medicinal chemistry letters, 2008, Feb-01, Volume: 18, Issue:3 Topics: Animals; Atorvastatin; Combinatorial Chemistry Techniques; Disease Models, Animal; Fluorobenzenes; Hepatocytes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Molecular Structure; Muscle Cells; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides	2008
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with Journal of medicinal chemistry, 2008, May-08, Volume: 51, Issue:9 Topics: Administration, Oral; Animals; Biological Availability; Chemical and Drug Induced Liver Injury; Cholesterol; Crystallography, X-Ray; Dogs; Female; Guinea Pigs; Haplorhini; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Liver; Models, Molecular; Muscle Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Triazoles	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24 Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
Metabolic interactions between mibefradil and HMG-CoA reductase inhibitors: an in vitro investigation with human liver preparations. British journal of clinical pharmacology, 1999, Volume: 47, Issue:3 Topics: Aryl Hydrocarbon Hydroxylases; Atorvastatin; Benzimidazoles; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Ketoconazole; Kinetics; Lovastatin; Mibefradil; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pyridines; Pyrroles; Simvastatin; Tetrahydronaphthalenes	1999
[Are all HMG-CoA reductase inhibitors protective against ischemic heart disease?]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1999, Volume: 114 Suppl 1 Topics: Adenosine Triphosphate; Animals; Atorvastatin; Dogs; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Myocardial Contraction; Myocardial Ischemia; Myocardial Stunning; Myocardium; Pravastatin; Pyridines; Pyrroles; Simvastatin	1999
Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:1 Topics: Animals; Aorta, Thoracic; Atorvastatin; Base Sequence; Botulinum Toxins; DNA Primers; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Mevalonic Acid; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phorbol 12,13-Dibutyrate; Pravastatin; Protein Kinase C; Pyridines; Pyrroles; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides; Vasodilation	2000
Lipophilic HMG-CoA reductase inhibitors increase myocardial stunning in dogs. Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:2 Topics: Adenosine Triphosphate; Animals; Atorvastatin; Cholesterol; Dogs; Fatty Acids, Monounsaturated; Female; Fluvastatin; Hemodynamics; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Myocardial Reperfusion Injury; Myocardial Stunning; Perfusion; Pyridines; Pyrroles; Random Allocation; Simvastatin; Solubility; Time Factors	2000
Pleiotropic effects of statins in atherosclerosis and diabetes. Diabetes care, 2000, Volume: 23 Suppl 2 Topics: Animals; Arteriosclerosis; Atorvastatin; Cell Division; Cell Movement; Cells, Cultured; Cholesterol; Cholesterol Esters; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Endocytosis; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins; Lovastatin; Macrophages; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Muscle, Smooth; Pyridines; Pyrroles; Simvastatin	2000
HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2000, Volume: 52, Issue:2 Topics: Animals; Atorvastatin; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Microsomes, Liver; Pravastatin; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Simvastatin; Species Specificity	2000
Lipid treatment goals achieved in patients treated with statin drugs in Norwegian general practice. The American journal of cardiology, 2000, Dec-01, Volume: 86, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Arteriosclerosis; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Cross-Sectional Studies; Family Practice; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipids; Male; Middle Aged; Norway; Pravastatin; Pyridines; Pyrroles; Retrospective Studies; Simvastatin; Surveys and Questionnaires	2000
Statin induced myopathy does not show up in MIBI scintigraphy. Nuclear medicine communications, 2001, Volume: 22, Issue:5 Topics: Adult; Anticholesteremic Agents; Atorvastatin; Breast Neoplasms; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Indoles; Lovastatin; Male; Middle Aged; Muscle, Skeletal; Muscular Diseases; Pain; Pravastatin; Pyridines; Pyrroles; Radionuclide Imaging; Radiopharmaceuticals; Simvastatin; Technetium Tc 99m Sestamibi	2001
A cost-effectiveness model of alternative statins to achieve target LDL-cholesterol levels. International journal of clinical practice, 2001, Volume: 55, Issue:4 Topics: Atorvastatin; Cholesterol, LDL; Coronary Disease; Cost-Benefit Analysis; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Models, Economic; Pravastatin; Pyridines; Pyrroles; Simvastatin	2001
Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:7 Topics: Acute Disease; Apoptosis; Atorvastatin; Cell Division; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Leukemia, Myeloid; Lovastatin; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyridines; Pyrroles; Sensitivity and Specificity; Tumor Cells, Cultured	2001
Managed care trends in statin usage. Managed care (Langhorne, Pa.), 2001, Volume: 10, Issue:10 Topics: Anticholesteremic Agents; Atorvastatin; Databases, Factual; Drug Costs; Drug Utilization Review; Fatty Acids, Monounsaturated; Fluvastatin; Health Care Sector; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Lovastatin; Managed Care Programs; Pravastatin; Pyridines; Pyrroles; Simvastatin; United States	2001
HMG-CoA reductase inhibitors reduce adhesion of human monocytes to endothelial cells. Biochemical and biophysical research communications, 2001, Dec-14, Volume: 289, Issue:4 Topics: Anticholesteremic Agents; Atorvastatin; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Gene Expression; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lipopolysaccharide Receptors; Monocytes; NF-kappa B; Pyridines; Pyrroles; Receptors, LDL; RNA, Messenger; Simvastatin; Tetradecanoylphorbol Acetate; U937 Cells; Vascular Cell Adhesion Molecule-1	2001
Statins have biphasic effects on angiogenesis. Circulation, 2002, Feb-12, Volume: 105, Issue:6 Topics: Animals; Apolipoproteins E; Apoptosis; Atorvastatin; Carcinoma, Lewis Lung; Cell Differentiation; Cell Division; Cell Movement; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lymphokines; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Pathologic; Neovascularization, Physiologic; Polyisoprenyl Phosphates; Pyridines; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2002
Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:5 Topics: Animals; Atorvastatin; Bile; Dogs; Glucuronides; Glucuronosyltransferase; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Magnetic Resonance Spectroscopy; Microsomes, Liver; Protein Isoforms; Pyridines; Pyrroles; Rats; Recombinant Proteins; Simvastatin; Uridine Diphosphate Glucuronic Acid	2002
Withdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in mice. Circulation research, 2002, Jul-26, Volume: 91, Issue:2 Topics: Acridines; Animals; Aorta; Atorvastatin; Cell Membrane; Cells, Cultured; Endothelium, Vascular; Fluoresceins; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADP; NADPH Oxidase 2; NADPH Oxidases; Organ Culture Techniques; Oxidative Stress; Protein Transport; Pyridines; Pyrroles; rac1 GTP-Binding Protein; Superoxides; Vasodilation	2002
Cerivastatin and atorvastatin inhibit IL-3-dependent differentiation and IgE-mediated histamine release in human basophils and downmodulate expression of the basophil-activation antigen CD203c/E-NPP3. Journal of leukocyte biology, 2003, Volume: 73, Issue:1 Topics: Antigens, CD; Atorvastatin; Basophils; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Down-Regulation; Heptanoic Acids; Histamine Release; Humans; Immunoglobulin E; Interleukin-3; Phosphoric Diester Hydrolases; Pyridines; Pyrophosphatases; Pyrroles	2003
Hydroxymethylglutaryl coenzyme A reductase inhibition reduces Chlamydia pneumoniae-induced cell interaction and activation. Circulation, 2003, Jul-22, Volume: 108, Issue:3 Topics: Animals; Arteriosclerosis; Atorvastatin; Cell Communication; Cell Membrane; Cells, Cultured; Chemokines; Chlamydophila Infections; Chlamydophila pneumoniae; Coculture Techniques; Dose-Response Relationship, Drug; Enzyme Activation; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Macrophages; Mice; Mice, Knockout; Muscle, Smooth, Vascular; NF-kappa B; Protein Prenylation; Pyridines; Pyrroles; rac1 GTP-Binding Protein; Reactive Oxygen Species; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction	2003
Interaction between fibrates and statins--metabolic interactions with gemfibrozil. Drug metabolism and drug interactions, 2003, Volume: 19, Issue:3 Topics: Atorvastatin; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gemfibrozil; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Microsomes, Liver; Pyridines; Pyrroles; Quinolines	2003
Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:8 Topics: Alitretinoin; Animals; Atorvastatin; Base Sequence; Cell Line; Cholesterol; Consensus Sequence; DNA-Binding Proteins; Gene Expression Regulation; Hepatocytes; Heptanoic Acids; Homeostasis; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver X Receptors; Lovastatin; Mevalonic Acid; Mice; Orphan Nuclear Receptors; Promoter Regions, Genetic; Proprotein Convertase 9; Proprotein Convertases; Pyridines; Pyrroles; Quinolines; Rats; Receptors, Cytoplasmic and Nuclear; Regulatory Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Alignment; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Simvastatin; Sp1 Transcription Factor; Species Specificity; Sterol Regulatory Element Binding Protein 2; Transcription Factors; Tretinoin	2004
Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators. Journal of cellular biochemistry, 2004, Nov-15, Volume: 93, Issue:5 Topics: Alkaline Phosphatase; Atorvastatin; Calcinosis; Dose-Response Relationship, Drug; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mevalonic Acid; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Polyisoprenyl Phosphates; Pyridines; Pyrroles; Sesquiterpenes	2004
Relaxant effects of pravastatin, atorvastatin and cerivastatin on isolated rat aortic rings. Life sciences, 2005, Feb-25, Volume: 76, Issue:15 Topics: Animals; Aorta, Thoracic; Atorvastatin; Endothelium, Vascular; Glyburide; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Nitroarginine; Ouabain; Pravastatin; Pyridines; Pyrroles; Rats; Rats, Wistar; Vasodilation	2005
Evaluation of apoptosis and necrosis induced by statins using fluorescence-enhanced flow cytometry. Journal of pharmaceutical and biomedical analysis, 2005, Sep-15, Volume: 39, Issue:3-4 Topics: Apoptosis; Atorvastatin; Avidin; Biotin; Cell Line; Cell Separation; Cells, Cultured; Drug Industry; Drug Screening Assays, Antitumor; Fatty Acids, Monounsaturated; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Leukemia; Microscopy, Fluorescence; Necrosis; Pharmaceutical Preparations; Pravastatin; Propidium; Pyridines; Pyrroles; Simvastatin; Time Factors	2005
Analysis of the global RNA expression profiles of skeletal muscle cells treated with statins. Journal of atherosclerosis and thrombosis, 2005, Volume: 12, Issue:3 Topics: Animals; Atorvastatin; Cell Culture Techniques; Cholesterol; Gene Expression Profiling; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Muscle Fibers, Skeletal; Myoblasts, Skeletal; Pyridines; Pyrroles; Quinolines; Rats; RNA, Messenger	2005
The effect of six different statins on the proliferation, migration, and invasion of human smooth muscle cells. The Journal of surgical research, 2005, Volume: 129, Issue:1 Topics: Atorvastatin; Cell Division; Cell Movement; Chemotaxis; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Myocytes, Smooth Muscle; Pravastatin; Pyridines; Pyrroles; Saphenous Vein; Simvastatin	2005
New light on statin side effects. What recent research on the cholesterol drugs means to you. Heart advisor, 2005, Volume: 8, Issue:8 Topics: Atorvastatin; Biomedical Research; Fluorobenzenes; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pravastatin; Pyridines; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides	2005
Differences between statins on clinical endpoints: a population-based cohort study. Current medical research and opinion, 2005, Volume: 21, Issue:9 Topics: Adult; Aged; Atorvastatin; Cardiovascular Diseases; Cholesterol; Cohort Studies; Endpoint Determination; Family Practice; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; Netherlands; Pravastatin; Pyridines; Pyrroles; Simvastatin; Treatment Outcome	2005
Statin-induced apoptosis linked with membrane farnesylated Ras small G protein depletion, rather than geranylated Rho protein. The Journal of pharmacy and pharmacology, 2005, Volume: 57, Issue:11 Topics: Animals; Apoptosis; Atorvastatin; Caspase 8; Cell Line; Fatty Acids, Monounsaturated; Flow Cytometry; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Membrane Lipids; Microscopy, Fluorescence; Myoblasts, Skeletal; Protein Prenylation; Pyridines; Pyrroles; ras Proteins; Rats; rho GTP-Binding Proteins; Signal Transduction	2005
Differential associations of statin and fibrate treatment with carotid arterial remodeling. American journal of hypertension, 2005, Volume: 18, Issue:11 Topics: Adult; Atorvastatin; Bezafibrate; Body Mass Index; Carotid Arteries; Cholesterol, HDL; Clofibric Acid; Cohort Studies; Dyslipidemias; Fatty Acids, Monounsaturated; Female; Fenofibrate; Fibric Acids; Fluvastatin; Gemfibrozil; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Indoles; Male; Middle Aged; Multivariate Analysis; Pravastatin; Pyridines; Pyrroles; Risk Factors; Simvastatin; Treatment Outcome; Tunica Intima; Tunica Media; Ultrasonography	2005
Effects of various statins on cytokine-dependent growth and IgE-dependent release of histamine in human mast cells. Allergy, 2006, Volume: 61, Issue:3 Topics: Apoptosis; Atorvastatin; Cell Differentiation; Cell Division; Cell Proliferation; Cells, Cultured; Cytokines; Heptanoic Acids; Histamine Release; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoglobulin E; Lovastatin; Mast Cells; Probability; Pyridines; Pyrroles; Sensitivity and Specificity	2006
RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. Cell death and differentiation, 2006, Volume: 13, Issue:11 Topics: Anticholesteremic Agents; Apoptosis; Atorvastatin; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Caspases; Cell Differentiation; Cell Survival; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Heptanoic Acids; Humans; Osteosarcoma; Phenotype; Phosphorylation; Polyisoprenyl Phosphates; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Pyridines; Pyrroles; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Simvastatin; Transforming Growth Factor beta	2006
Hydroxymethylglutaryl-CoA reductase inhibitors in older persons with acute myocardial infarction: evidence for an age-statin interaction. Journal of the American Geriatrics Society, 2006, Volume: 54, Issue:3 Topics: Age Factors; Aged, 80 and over; Atorvastatin; Cholesterol, LDL; Drug Prescriptions; Fatty Acids, Monounsaturated; Female; Fluvastatin; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Myocardial Infarction; Odds Ratio; Pravastatin; Pyridines; Pyrroles; Retrospective Studies; Survival Rate; Treatment Outcome	2006
Inhibitory effects of statins on human monocarboxylate transporter 4. International journal of pharmaceutics, 2006, Jul-06, Volume: 317, Issue:1 Topics: Animals; Atorvastatin; Basigin; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lactic Acid; LLC-PK1 Cells; Lovastatin; Monocarboxylic Acid Transporters; Muscle Proteins; Pyridines; Pyrroles; Simvastatin; Swine; Transfection	2006
Differential effects of different statins on endothelin-1 gene expression and endothelial NOS phosphorylation in porcine aortic endothelial cells. Experimental biology and medicine (Maywood, N.J.), 2006, Volume: 231, Issue:6 Topics: Animals; Aorta; Atorvastatin; Cells, Cultured; Endothelial Cells; Endothelin-1; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide Synthase Type III; Phosphorylation; Pravastatin; Pyridines; Pyrroles; Quinolines; RNA, Messenger; Swine	2006
Toxicity of statins on rat skeletal muscle mitochondria. Cellular and molecular life sciences : CMLS, 2006, Volume: 63, Issue:19-20 Topics: Animals; Apoptosis; Atorvastatin; Cytochromes c; DNA Fragmentation; Fatty Acids; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Membrane Potentials; Mitochondria, Muscle; Mitochondrial Membranes; Muscle, Skeletal; Oxygen; Pravastatin; Pyridines; Pyrroles; Rats; Simvastatin	2006
Flow cytometric evaluation of synergistic pro-apoptotic effects of statins and clofibrates in IM-9 human lymphoblasts. Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:9 Topics: Antineoplastic Agents; Apoptosis; Atorvastatin; Caspase 3; Cell Line; Clofibrate; DNA Fragmentation; Drug Synergism; Enzyme Activation; Flow Cytometry; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lymphocytes; Pravastatin; Pyridines; Pyrroles	2007
Estimating the extent of reporting to FDA: a case study of statin-associated rhabdomyolysis. Pharmacoepidemiology and drug safety, 2008, Volume: 17, Issue:3 Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Atorvastatin; Child; Child, Preschool; Female; Heptanoic Acids; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Infant; Male; Middle Aged; Pravastatin; Pyridines; Pyrroles; Retrospective Studies; Rhabdomyolysis; Simvastatin; United States; United States Food and Drug Administration	2008
3-Hydroxy-3-methylglutaryl coenzyme A reductase in rainbow trout: effects of fasting and statin drugs on activities and mRNA transcripts. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2008, Volume: 147, Issue:3 Topics: Amino Acid Sequence; Animals; Atorvastatin; Brain; Cholesterol; Dose-Response Relationship, Drug; Fasting; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoenzymes; Liver; Molecular Sequence Data; Oncorhynchus mykiss; Phosphorylation; Pyridines; Pyrroles; RNA, Messenger; Time Factors; Water Pollutants, Chemical	2008
Effect of APOE genotype on lipid levels in patients with coronary heart disease during a 3-week inpatient rehabilitation program. Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:2 Topics: Adult; Aged; Alleles; Apolipoprotein E2; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Decision Making; Fatty Acids, Monounsaturated; Female; Fluvastatin; Genotype; Germany; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Inpatients; Linear Models; Lovastatin; Male; Middle Aged; Multivariate Analysis; Pravastatin; Predictive Value of Tests; Pyridines; Pyrroles; Simvastatin; Triglycerides	2008
Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Animals; Atorvastatin; Hepatocytes; Heptanoic Acids; Indomethacin; Male; Models, Biological; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley	2008
Statin-induced liver injury involves cross-talk between cholesterol and selenoprotein biosynthetic pathways. Molecular pharmacology, 2009, Volume: 75, Issue:6 Topics: Atorvastatin; Cell Line, Tumor; Cholesterol; Cytotoxins; Glutathione Peroxidase; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoenzymes; Lovastatin; Pyridines; Pyrroles; Reactive Oxygen Species; Selenoproteins; Signal Transduction; tert-Butylhydroperoxide; Thioredoxin-Disulfide Reductase	2009
[Metabolic rhabdomyolysis during statin therapy]. La Revue de medecine interne, 2009, Volume: 30, Issue:8 Topics: Atorvastatin; Carnitine O-Palmitoyltransferase; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pyridines; Pyrroles; Rhabdomyolysis	2009
Autocrine amplification loop in statin-induced apoptosis of human melanoma cells. British journal of pharmacology, 2009, Volume: 157, Issue:7 Topics: Antineoplastic Agents; Apoptosis; Atorvastatin; Autocrine Communication; Biological Factors; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Enzyme Activation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Melanoma; Pyridines; Pyrroles; Simvastatin; Time Factors	2009
Rhabdomyolysis a result of azithromycin and statins: an unrecognized interaction. British journal of clinical pharmacology, 2009, Volume: 68, Issue:3 Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Atorvastatin; Azithromycin; Databases, Factual; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Middle Aged; Pravastatin; Pyridines; Pyrroles; Rhabdomyolysis; Simvastatin	2009
Prooxidative toxicity and selenoprotein suppression by cerivastatin in muscle cells. Toxicology letters, 2012, Dec-17, Volume: 215, Issue:3 Topics: Animals; Atorvastatin; Cell Line; Cell Survival; Gene Expression Regulation; Heptanoic Acids; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mice; Myoblasts; Oxidative Stress; Pyridines; Pyrroles; Rats; Selenium; Selenoproteins	2012
Long-term follow-up on the effect of combined therapy of bile acids and statins in the treatment of cerebrotendinous xanthomatosis: a case report. Clinical neurology and neurosurgery, 2014, Volume: 118 Topics: Adult; Atorvastatin; Chenodeoxycholic Acid; Cognition; Drug Therapy, Combination; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Neuropsychological Tests; Pyridines; Pyrroles; Simvastatin; Treatment Outcome; Xanthomatosis, Cerebrotendinous	2014