Page last updated: 2024-08-24

atorvastatin and acetylcysteine

atorvastatin has been researched along with acetylcysteine in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (15.79)29.6817
2010's12 (63.16)24.3611
2020's4 (21.05)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Diehl, JF; Dimmeler, S; Haendeler, J; Hoffmann, J; Spyridopoulos, I; Vasa, M; Zeiher, AM1
Lóopez-Marure, R; Massó, FA; Montaño, LF; Páez, A; Rodríguez, E; Sánchez, CA; Varela, E; Zapata, E1
Amato, M; Bellandi, F; Gallopin, M; Leoncini, M; Maioli, M; Manzone, C; Micheletti, C; Tedeschi, D; Toso, A1
Alemdar, R; Aydin, M; Basar, C; Caglar, O; Erden, I; Ordu, S; Ozhan, H; Yalcin, S1
Biswas, D; Biswas, T; Sarkar, A; Sen, G1
Bianco, A; Briguori, C; Colombo, A; Condorelli, G; De Micco, F; Donnarumma, E; Fiore, D; Focaccio, A; Golia, B; Quintavalle, C; Ricciardelli, B; Troncone, G; Visconti, G; Zabatta, MA1
Cai, DQ; Kim, CS; Kim, DH; Kim, SK; Lee, KJ; Qi, XF; Qin, JW; Wu, Z; Yu, YH; Zheng, L1
Caristo, ME; Ciavarella, LP; Citterio, F; Copponi, G; Crea, F; Cusumano, G; Giubilato, S; Liuzzo, G; Manchi, M; Romagnoli, J; Severino, A; Stigliano, E; Zannoni, GF1
Alexandropoulos, D; Arkadopoulos, N; Bazigos, GV; Doulamis, IP; Kondi-Pafiti, A; Konstantopoulos, P; Kotsis, T; Perrea, DN; Smyrniotis, V; Tragotsalou, N; Tzani, A1
Ababneh, MA; Al Demour, S; Alzoubi, KH; Hijjawi, TB; Rababa’h, AM1
Erdi, I; Kaya, B; Yasar, M1
Guo, DW; Shih, HC; Wang, CY1
Bar-Klein, G; Friedman, A; Hameed, MQ; Jozwiak, S; Kaminski, RM; Klein, P; Klitgaard, H; Koepp, M; Löscher, W; Prince, DA; Rotenberg, A; Twyman, R; Vezzani, A; Wong, M1
Alshogran, OY; Alzoubi, KH; El-Elimat, T; Nusair, SD; Obeidat, A; Sweidan, M1
Björnsson, ES1
Cervantes-Cardona, GA; Cervantes-Guevara, G; Cervantes-Pérez, E; Cervantes-Pérez, G; Cervantes-Pérez, LA; Fuentes-Orozco, C; González-Ojeda, A; Hernández-Mora, FJ; Hernández-Rivas, MI; Nápoles-Echauri, A; Ramírez-Ochoa, S; Reyes-Torres, CA; Ron-Magaña, AL; Vázquez-Beltrán, JC1

Reviews

3 review(s) available for atorvastatin and acetylcysteine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?
    Epilepsia, 2020, Volume: 61, Issue:3

    Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Atorvastatin; Brain Injuries, Traumatic; Ceftriaxone; Dibenzazepines; Drug Repositioning; Epilepsy; Epilepsy, Post-Traumatic; Erythropoietin; Fingolimod Hydrochloride; GABA Agents; Gabapentin; Humans; Immunologic Factors; Inflammation; Interleukin 1 Receptor Antagonist Protein; Isoflurane; Levetiracetam; Losartan; Neuroprotective Agents; Oxidative Stress; Pregabalin; Pyrrolidinones; Sirolimus; Stroke; Topiramate; Translational Research, Biomedical; Vigabatrin

2020
Clinical management of patients with drug-induced liver injury (DILI).
    United European gastroenterology journal, 2021, Volume: 9, Issue:7

    Topics: Acetylcysteine; Aged; Anti-Bacterial Agents; Anticholesteremic Agents; Atorvastatin; Azithromycin; Checklist; Chemical and Drug Induced Liver Injury; Female; Humans; Jaundice; Middle Aged; Pruritus; Symptom Assessment

2021

Trials

4 trial(s) available for atorvastatin and acetylcysteine

ArticleYear
Usefulness of atorvastatin (80 mg) in prevention of contrast-induced nephropathy in patients with chronic renal disease.
    The American journal of cardiology, 2010, Feb-01, Volume: 105, Issue:3

    Topics: Acetylcysteine; Acute Kidney Injury; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticholesteremic Agents; Atorvastatin; Biomarkers; Contrast Media; Coronary Angiography; Creatinine; Female; Fluid Therapy; Heptanoic Acids; Humans; Male; Prospective Studies; Pyrroles; Renal Insufficiency, Chronic; Risk Factors

2010
Efficacy of short-term high-dose atorvastatin for prevention of contrast-induced nephropathy in patients undergoing coronary angiography.
    Angiology, 2010, Volume: 61, Issue:7

    Topics: Acetylcysteine; Acute Kidney Injury; Adult; Atorvastatin; Contrast Media; Coronary Angiography; Creatinine; Female; Glomerular Filtration Rate; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pyrroles

2010
Impact of a high loading dose of atorvastatin on contrast-induced acute kidney injury.
    Circulation, 2012, Dec-18, Volume: 126, Issue:25

    Topics: Acetylcysteine; Acute Kidney Injury; Aged; Animals; Atorvastatin; Cells, Cultured; Contrast Media; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Pyrroles; Tumor Suppressor Protein p53

2012
Evaluation of the Effects of Atorvastatin and N-Acetyl Cysteine on Platelet Counts in Patients with Primary Immune Thrombocytopenia: An Exploratory Clinical Trial.
    Medicina (Kaunas, Lithuania), 2023, Jun-11, Volume: 59, Issue:6

    Topics: Acetylcysteine; Atorvastatin; Humans; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia; Treatment Outcome

2023

Other Studies

12 other study(ies) available for atorvastatin and acetylcysteine

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells.
    Circulation research, 2004, Apr-02, Volume: 94, Issue:6

    Topics: Acetylcysteine; Antioxidants; Atorvastatin; Cell Nucleus; Cells, Cultured; Cellular Senescence; Depression, Chemical; DNA Replication; DNA-Binding Proteins; DNA, Mitochondrial; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Heptanoic Acids; Humans; Hydrogen Peroxide; Oxidation-Reduction; Oxidative Stress; Protein Transport; Pyrimidines; Pyrroles; Reactive Oxygen Species; src-Family Kinases; Telomerase

2004
Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.
    Cancer investigation, 2008, Volume: 26, Issue:7

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Atorvastatin; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Proliferation; DNA Replication; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Membrane Potential, Mitochondrial; Necrosis; Oxidative Stress; Pyrroles; Reactive Oxygen Species; Simvastatin

2008
Atorvastatin acts synergistically with N-acetyl cysteine to provide therapeutic advantage against Fas-activated erythrocyte apoptosis during chronic arsenic exposure in rats.
    Toxicology and applied pharmacology, 2011, Jan-01, Volume: 250, Issue:1

    Topics: Acetylcysteine; Animals; Anticholesteremic Agents; Apoptosis; Arsenic; Arsenic Poisoning; Atorvastatin; Cell Membrane; Drug Synergism; Environmental Pollutants; Erythrocytes; fas Receptor; Free Radical Scavengers; Glutathione; Heptanoic Acids; Male; Oxidative Stress; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction

2011
HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway.
    Cell death & disease, 2013, Feb-28, Volume: 4

    Topics: Acetylcysteine; Acyl Coenzyme A; Animals; Antioxidants; Apoptosis; Atorvastatin; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; DNA Fragmentation; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lymphoma; Membrane Potential, Mitochondrial; Mevalonic Acid; Mice; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Reactive Oxygen Species; Signal Transduction; Simvastatin

2013
N-Acetylcysteine and High-Dose Atorvastatin Reduce Oxidative Stress in an Ischemia-Reperfusion Model in the Rat Kidney.
    Transplantation proceedings, 2015, Volume: 47, Issue:9

    Topics: Acetylcysteine; Animals; Atorvastatin; Catalase; Female; Free Radical Scavengers; Glutathione Peroxidase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Kidney Diseases; Oxidation-Reduction; Oxidative Stress; Peroxidase; Rats; Reperfusion Injury; Superoxide Dismutase

2015
Protective effects of N-acetylcystein and atorvastatin against renal and hepatic injury in a rat model of intestinal ischemia-reperfusion.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 89

    Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antioxidants; Atorvastatin; Drug Therapy, Combination; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestines; Kidney Function Tests; Liver Diseases; Liver Function Tests; Male; Protective Agents; Rats; Rats, Wistar; Reperfusion Injury

2017
The Nephroprotective Effect of N-Acetyl-L-Cysteine and Atorvastatin against Imipenem induced Nephrotoxicity.
    Current molecular pharmacology, 2018, Volume: 11, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Atorvastatin; Blood Urea Nitrogen; Creatinine; Glomerular Filtration Rate; Glycosuria; Imipenem; Kidney; Kidney Diseases; Male; Protective Agents; Proteinuria; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Urea

2018
The preventive effects of atorvastatin and N-acetyl cysteine in experimentally induced ischemia-reperfusion injury in rats.
    Bratislavske lekarske listy, 2018, Volume: 119, Issue:3

    Topics: Acetylcysteine; Animals; Atorvastatin; Catalase; Cecal Diseases; Cecum; Disease Models, Animal; Female; Free Radical Scavengers; Glutathione Peroxidase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Volvulus; Male; Malondialdehyde; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase

2018
N-acetylcysteine and atorvastatin alleviates lung injury due to ischemia-reperfusion injury in rats.
    Journal of the Chinese Medical Association : JCMA, 2019, Volume: 82, Issue:12

    Topics: Acetylcysteine; Animals; Atorvastatin; Cytokines; Lung Injury; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2019
Evaluation of coenzyme Q10 combined with or without N-acetyl cysteine or atorvastatin for preventing contrast-induced kidney injury in diabetic rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:7

    Topics: Acetylcysteine; Acute Kidney Injury; Animals; Atorvastatin; Contrast Media; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Drug Therapy, Combination; Male; Rats; Rats, Sprague-Dawley; Ubiquinone

2021