Page last updated: 2024-09-04

atazanavir sulfate and rifampin

atazanavir sulfate has been researched along with rifampin in 7 studies

Compound Research Comparison

Studies (atazanavir sulfate)	Trials (atazanavir sulfate)	Recent Studies (post-2010) (atazanavir sulfate)	Studies (rifampin)	Trials (rifampin)	Recent Studies (post-2010) (rifampin)
1,102	246	590	20,468	1,499	6,552

Protein Interaction Comparison

Protein	Taxonomy	rifampin (IC50)
Polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus (rabbit)	2.949
Caspase-1	Homo sapiens (human)	8.319
Alpha-synuclein	Homo sapiens (human)	7.1
Enoyl-[acyl-carrier-protein] reductase [NADH]	Mycobacterium tuberculosis H37Rv	0.03
DNA-directed RNA polymerase subunit beta	Mycobacterium tuberculosis H37Rv	0.01
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	1.5
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	1.5

Research

Studies (7)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (71.43)	29.6817
2010's	1 (14.29)	24.3611
2020's	1 (14.29)	2.80

Authors

Authors	Studies
Agarwala, S; Been-Tiktak, A; Bertz, R; Burger, DM; Child, M; Wang, Y	1
Blanco, JL; Gatell, JM; López-Púa, Y; Mallolas, J; Martínez, E; Nomdedeu, M; Sarasa, M; Soriano, A	1
Acosta, EP; Agarwala, S; Alston-Smith, B; Bertz, R; Child, M; Gerber, JG; Haas, DW; Hosey, L; Kendall, MA; Koletar, SL; Zolopa, AR	1
Bendayan, M; Bendayan, R; Chan, GN; Couraud, PO; Ramaswamy, M; Romero, IA; Ronaldson, PT; Weksler, B; Zastre, JA	1
Acosta, EP; Alston-Smith, B; Bertz, R; Child, MJ; Gerber, JG; Haas, DW; Hosey, L; Kendall, MA; Koletar, SL; Laughlin, L; Suckow, C; Zolopa, AR	1
Bow, DA; Chiou, WJ; de Morais, SM; Kikuchi, R; Li, X; Voorman, RL	1
Bunglawala, F; Cottura, N; Denti, P; Fabrega, F; Howarth, A; Kinvig, H; Lloyd, A; Montanha, MC; Siccardi, M; Waitt, C	1

Trials

2 trial(s) available for atazanavir sulfate and rifampin

Article	Year
Effect of rifampin on steady-state pharmacokinetics of atazanavir with ritonavir in healthy volunteers. Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:10 Topics: Anti-HIV Agents; Area Under Curve; Atazanavir Sulfate; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Male; Oligopeptides; Pyridines; Rifampin; Ritonavir	2006
Hepatotoxicity and gastrointestinal intolerance when healthy volunteers taking rifampin add twice-daily atazanavir and ritonavir. Journal of acquired immune deficiency syndromes (1999), 2009, Mar-01, Volume: 50, Issue:3 Topics: Adult; Antitubercular Agents; Atazanavir Sulfate; Female; Gastrointestinal Tract; HIV Protease Inhibitors; Humans; Liver; Male; Oligopeptides; Pyridines; Rifampin; Ritonavir	2009

Article

Year

Effect of rifampin on steady-state pharmacokinetics of atazanavir with ritonavir in healthy volunteers.

Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:10

Topics: Anti-HIV Agents; Area Under Curve; Atazanavir Sulfate; Drug Interactions; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Male; Oligopeptides; Pyridines; Rifampin; Ritonavir

2006

Hepatotoxicity and gastrointestinal intolerance when healthy volunteers taking rifampin add twice-daily atazanavir and ritonavir.

Journal of acquired immune deficiency syndromes (1999), 2009, Mar-01, Volume: 50, Issue:3

Topics: Adult; Antitubercular Agents; Atazanavir Sulfate; Female; Gastrointestinal Tract; HIV Protease Inhibitors; Humans; Liver; Male; Oligopeptides; Pyridines; Rifampin; Ritonavir

2009

Other Studies

5 other study(ies) available for atazanavir sulfate and rifampin

Article	Year
Pharmacokinetic interaction between rifampicin and ritonavir-boosted atazanavir in HIV-infected patients. HIV medicine, 2007, Volume: 8, Issue:2 Topics: Adult; AIDS-Related Opportunistic Infections; Antibiotics, Antitubercular; Area Under Curve; Atazanavir Sulfate; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Drug Therapy, Combination; Female; HIV Protease Inhibitors; Humans; Male; Oligopeptides; Prospective Studies; Pyridines; Rifampin; Ritonavir; Tuberculosis	2007
Effect of concomitantly administered rifampin on the pharmacokinetics and safety of atazanavir administered twice daily. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:9 Topics: Adolescent; Adult; Anti-HIV Agents; Antitubercular Agents; Area Under Curve; Atazanavir Sulfate; Biotransformation; Drug Interactions; Female; Half-Life; HIV Infections; Humans; Male; Middle Aged; Oligopeptides; Pyridines; Rifampin; Tuberculosis	2007
Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line. Journal of neuroscience research, 2009, Volume: 87, Issue:4 Topics: Atazanavir Sulfate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Cell Line; Cyclosporins; Diphosphonates; Endothelium, Vascular; HIV Protease Inhibitors; Humans; Microvessels; Oligopeptides; Propionates; Pyridines; Quinolines; Rifampin; Ritonavir; Tritium; Up-Regulation	2009
In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia. Xenobiotica; the fate of foreign compounds in biological systems, 2014, Volume: 44, Issue:3 Topics: Antirheumatic Agents; Atazanavir Sulfate; Bilirubin; Carbamates; Cyclosporine; Furans; Glucuronosyltransferase; HIV Protease Inhibitors; Hyperbilirubinemia; In Vitro Techniques; Indinavir; Liver-Specific Organic Anion Transporter 1; Oligopeptides; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Pyridines; Rifampin; Rifamycins; Saquinavir; Solute Carrier Organic Anion Transporter Family Member 1B3; Sulfonamides	2014
Predicting Drug-Drug Interactions between Rifampicin and Ritonavir-Boosted Atazanavir Using PBPK Modelling. Clinical pharmacokinetics, 2022, Volume: 61, Issue:3 Topics: Anti-HIV Agents; Atazanavir Sulfate; Drug Interactions; HIV Infections; HIV Protease Inhibitors; Humans; Rifampin; Ritonavir	2022