astragaloside a has been researched along with beta-escin in 600 studies
| Studies (astragaloside a) | Trials (astragaloside a) | Recent Studies (post-2010) (astragaloside a) | Studies (beta-escin) | Trials (beta-escin) | Recent Studies (post-2010) (beta-escin) |
|---|---|---|---|---|---|
| 675 | 5 | 573 | 14,137 | 211 | 6,278 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (0.33) | 18.7374 |
| 1990's | 6 (1.00) | 18.2507 |
| 2000's | 69 (11.50) | 29.6817 |
| 2010's | 338 (56.33) | 24.3611 |
| 2020's | 185 (30.83) | 2.80 |
| Authors | Studies |
|---|---|
| Ding, Y; Huang, DK; Shen, JP; Zhang, XL; Zhang, YD; Zhu, SH | 1 |
| Yu, JH | 1 |
| He, K; Wang, HK | 1 |
| Kang, T; Liu, K; Meng, S; Zhang, Z; Zhao, Y | 1 |
| Dai, RH; Li, Y; Luo, HM | 1 |
| Bi, K; Che, C; Luo, X; Qi, Y; Wang, X; Yao, M | 1 |
| Guan, Y; Guo, N; Wang, J; Yan, R | 1 |
| Li, Y; Zhen, H | 1 |
| Fitzloff, JF; Li, W | 1 |
| Chen, MZ; He, GW; Lu, JT; Wang, B; Yang, Q; Zhou, AW | 1 |
| Hu, ZB; Li, XY; Song, CQ; Wang, YP | 1 |
| Lu, J; Zhou, CL | 1 |
| Cao, Q; Li, ZP | 1 |
| Fan, Y; Hu, ZB; Kong, JL; Wu, DZ; Zhou, JY | 1 |
| Ma, Z; Yang, Z | 1 |
| Tong, L; Wu, ZH; Xing, XF; You, WW | 1 |
| Binder, BR; Hufnagl, P; Wojta, J; Zhang, WJ | 1 |
| Branford-White, CJ; Ding, J; Du, M; Hu, ZB; White, KN; Wu, XJ | 1 |
| Fawcett, JP; Gu, Y; Wang, G | 1 |
| Chen, J; Ding, D; Fu, JH; Hong, Z; Luo, Y; Qin, Z; Zhang, WD; Zhang, X | 1 |
| Yu, QC; Zhang, YK; Zhu, TY | 1 |
| A, J; Fawcett, JP; Gu, Y; Pan, G; Sun, J; Wang, G | 1 |
| Feng, S; Hu, F; Liu, X; Xu, J; Zhao, J | 1 |
| Bian, YY; Chen, XJ; Li, P; Meng, D; Yang, D; Zhang, JN | 1 |
| Chen, XG; Kong, L; Li, P; Li, SL; Mao, XQ; Sheng, LH; Su, XY; Zou, HF | 1 |
| Chen, C; Li, H; Liu, R; Mao, C; Zhang, C; Zhang, J; Zhang, W | 1 |
| Guo, DA; Yan, LX | 1 |
| Abou-Gazar, H; Arrieta, J; Calis, I; Navarrete, A; Terrones, L | 1 |
| Huang, C; Li, H; Lv, H; Lv, T; Sun, J; Wang, G; Xie, H | 1 |
| Chen, GW; Chen, YS; Cheng, CY; Liu, BS; Liu, CJ; Yao, CH | 1 |
| Guan, S; Huang, M; Sun, H | 1 |
| Ou-Yang, Y; Sun, YH; Xiao, SZ; Xu, ME; Zheng, XX | 1 |
| Chen, H; Chen, HZ; Li, HL; Liu, RH; Zhang, C; Zhang, WD | 1 |
| Cui, X; Gao, Y; Gong, W; Guo, S; Huang, C; Huang, Y; Zhang, Y; Zhao, Y; Zhu, H | 1 |
| Chen, CL; Li, HL; Liu, RH; Mao, C; Moran, S; Zhang, C; Zhang, JT; Zhang, WD | 1 |
| Cheung, AW; Dong, TT; Duan, R; Gao, QT; Ji, ZN; Li, J; Tsim, KW; Zhao, KJ; Zhu, TT | 1 |
| Ge, YK; Li, HB; Zhang, L; Zheng, XX | 1 |
| Chen, H; Gao, PJ; Li, HL; Liu, RH; Wang, XH; Zhang, C; Zhang, WD; Zhu, DL | 1 |
| Jiang, S; Qiu, J; Shen, J; Sun, S; Yin, H; Yin, X; Yu, J; Zhang, Y | 1 |
| Komatsu, K; Matsuyama, S; Tamura, T; Tohda, C | 1 |
| Bian, YY; Guan, J; Li, P; Li, SL; Song, Y; Wang, D | 1 |
| Chai, YF; Li, X; Lou, ZY; Wang, B; Zhu, ZY | 1 |
| Bi, ZM; Guan, J; Li, P | 1 |
| Chen, JB; Li, L; Tao, HY | 1 |
| Jiang, XQ; Lin, J; Liu, HJ; Wang, XP; Yu, YC; Zhang, WD; Zhang, XL; Zhou, ZT | 1 |
| Chen, HZ; Chen, RZ; Ge, JB; Li, SJ; Yang, YZ; Zhang, ZC | 1 |
| Cheng, YP; Gu, SY; Huang, QJ; Ji, H; Shao, Q; Xu, XL | 1 |
| Han, QB; Mo, SF; Qiao, CF; Song, JZ; Xu, HX; Yip, YK | 1 |
| Deng, CQ; Deng, KW; He, FY; Liu, W; Liu, WL; Luo, JY | 1 |
| Bi, Z; Li, P; Qi, LW; Yi, L; Yu, QT; Zhao, J | 1 |
| Liang, XM; Sun, YG; Xiao, HB; Xue, XY; Zhang, X | 1 |
| Li, SJ; Yang, YZ; Zhang, ZC | 1 |
| Hu, JY; Huang, YS; Song, HP; Teng, M; Xiang, F; Zhang, DX; Zhang, Q; Zhu, ZG | 1 |
| Bao, HB; He, KP; Li, H; Yang, KD | 1 |
| Chen, Z; Li, SP; Sun, Z; Xu, XY | 1 |
| He, XP; Li, RX; Qi, L; Rui, YF; Xie, ZP; Zhu, SQ | 1 |
| Ai, P; Dingkun, G; Kaiyuan, Z; Qiuyu, Z; Shanyan, L; Yong, G | 1 |
| Li, WP; Li, WZ; Yin, YY | 1 |
| Bao, KD; Li, CY; Li, P; Qi, LW; Wen, XD; Yan, XW; Yi, L | 1 |
| Bian, YY; Bian, ZP; Chen, XJ; Ji, H; Li, P; Xu, JD; Xu, XL; Yang, D; Zhang, JN | 1 |
| Liu, F; Liu, M; Zhang, QW; Zhou, J | 1 |
| Han, YM; Liu, P; Xia, GP | 1 |
| Ge, Y; Kuang, R; Yan, M; Yuan, W; Zhang, Y; Zheng, X | 1 |
| Chen, Z; Du, Q; Huang, M; Yin, KS; Zhang, Q; Zhou, LF | 1 |
| Chen, J; Chen, Y; Gui, D; Huang, J; Liu, Y; Mou, L | 1 |
| Gao, GL; Huang, HP; Li, YL; Liu, CX | 1 |
| Chen, M; Jiang, B; Jin, H; Qian, L; Shang, W; Yang, Y; Zhou, L | 1 |
| Chu, ZG; Han, J; Hu, JY; Huang, YS; Song, HP; Zhang, DX; Zhang, Q | 1 |
| Gao, W; Huang, H; Kong, D; Li, B; Li, J; Wang, S; Zhou, P; Zhuang, C | 1 |
| Jiangbo, Z; Tianbao, Z; Xili, M; Xuying, W; Yiwen, Z; Yuping, Z | 1 |
| Gao, GD; Gao, L; Li, M; Liu, JP; Qu, YZ; Wei, XY; Zhao, YL; Zhao, ZW | 1 |
| Wang, Z; Yang, D; Zhu, L | 1 |
| Chan, WS; Durairajan, SS; Koo, I; Kum, WF; Li, M; Lu, JH; Wang, Y; Xie, LX; Yung, KK | 1 |
| Li, X; Liu, H; Sun, WY; Wei, W | 1 |
| Liu, ZQ; Lv, L; Pang, JX; Rao, JJ; Wang, GF; Wu, SG; Wu, SY; Xu, W; Zhang, JJ | 1 |
| Fujiwara, Y; Ikeda, T; Kiyota, N; Motomura, K; Nagai, R; Nohara, T; Takeya, M; Tsurushima, K | 1 |
| Bi, CW; Chen, VP; Cheung, AW; Choi, RC; Dong, TT; Duan, R; Guo, AJ; Lau, BW; Lau, DD; Li, J; Tsim, KW; Xie, HQ; Zheng, YZ; Zhu, JT; Zhu, Y | 1 |
| Chen, HF; Deng, Y | 1 |
| Ionkova, I; Momekov, G; Proksch, P | 1 |
| Han, Y; Lau, AS; Qi, H; Rong, J; Wei, L; Zhang, Q | 1 |
| Chen, L; Chen, YJ; Li, JQ; Liu, DS; Liu, L; Ou, XM; Sun, BB; Wang, HX; Wang, T; Wang, X; Wen, FQ; Xu, D; Yang, T; Zhang, SF; Zhou, H | 1 |
| Hu, Z; Liu, Y; Ma, C; Shi, H; Wu, D; Zhou, J | 1 |
| Qiu, LH; Xie, XJ; Zhang, BQ | 1 |
| Tan, YF; Wang, Y; Xiong, YJ; Yin, XC | 1 |
| Gong, HL; Li, WP; Li, WZ; Wu, GC; Yin, YY; Zhu, FF | 1 |
| Li, W; Sun, X; Xu, X; Zhang, W; Zhou, S | 1 |
| Chen, CY; Fu, YJ; Kong, Y; Liu, W; Luo, M; Wink, M; Yan, MM; Zhao, BS; Zu, YG | 1 |
| Chen, YS; Ruan, M; Yu, B; Zhang, LY; Zhuang, Y | 1 |
| Jiang, LZ; Liao, XQ; Xiong, P | 1 |
| Sun, S; Sun, Y; Wang, S; Yuan, X | 1 |
| Cao, W; Ding, GR; Guo, GZ; Guo, J; Li, KC; Li, YR; Miao, S; Wang, J | 1 |
| Cassileth, B; George, C; Hong, F; Kennelly, E; Lau, CB; Leung, PC; Livingston, PO; Ragupathi, G; Xiao, W; Yeung, KS | 1 |
| Cai, SQ; Li, XM; Liu, SY; Meng, LQ; Qu, L; Shang, MY; Tang, JW; Wang, Y; Zhang, M; Zhao, JR | 1 |
| Wu, GC; Yin, YY; Zhu, FF | 1 |
| Chen, H; Chen, P; Chen, R; Ge, J; Li, GG; Shen, E; Xie, Y; Yang, Y; Yu, Y; Zhang, CB; Zou, Y | 1 |
| Bian, Q; Hou, W; Huang, JH; Liang, QQ; Lu, S; Shi, Q; Shu, B; Wang, YJ; Xu, H; Zhao, YJ | 1 |
| Liu, X; Min, W | 1 |
| Gao, H; Jiang, F; Liu, F; Qu, Z; Shang, L; Sun, L; Wang, S; Wang, Y | 1 |
| He, Q; Lai, H; Wang, J; Xiong, M | 2 |
| Mao, SL; Wang, XH; Zhang, N; Zhao, F | 1 |
| Gao, X; Liu, Q; Lu, L; Wang, Y; Zhang, L; Zhao, X | 1 |
| Hu, ZB; Wang, ZT; Wang, ZY | 1 |
| Li, JH; Wan, HT; Zhu, ZH | 1 |
| Cai, YL; Chen, ZZ; Cheng, MX; Liu, CA; Tu, B | 1 |
| Chen, Z; Li, X; Xu, Q; Yang, S; Zhang, M | 1 |
| Guo, W; Han, Y; Xie, Y; Yan, S; Zhu, B | 1 |
| Chai, JD; Ji, KT; Tang, JF | 1 |
| Feng, J; Li, Y; Lu, S; Mo, K; Qin, J | 1 |
| He, CZ; Li, SJ | 1 |
| Bi, Z; Chen, X; Cui, L; Ji, C; Wan, Y; Xu, J; Yang, B | 1 |
| Ja, J; Pei, C; Song, J; Wang, Z | 1 |
| Chin, AC; Harley, CB; Ho, MK; Hu, Y; Ip, FC; Ip, NY; Lam, WS; Pang, H; Wong, YH; Yung, LY | 1 |
| Chen, Y; Deng, Y; Fan, J; Wang, L; Zhang, M; Zheng, R; Zhong, Y; Zhu, R | 1 |
| Liu, YX; Peng, Y; Song, JQ; Wang, YY; Wu, YN; Zhang, Q | 1 |
| Chen, X; Fung, KP; Gao, JQ; Leung, PC; Li, N; Li, P; Li, QM; Peng, LH | 1 |
| Cai, WJ; Chen, WH; Cheng, J; Hu, GR; Liu, RH; Shen, ZY; Ying, J; Zhang, XM | 1 |
| Chan, SW; Hong, SJ; Hu, G; Kwan, YW; Lam, CO; Lee, SM; Leung, GP; Li, S; Li, ZH; Zhang, Y | 1 |
| Li, J; Lu, J; Wan, H; Yang, J; Zhang, Y; Zhu, Z | 1 |
| Kwon, HJ; Park, YD | 1 |
| Gao, GD; Li, LH; Qin, HZ; Wang, JL; Wu, L; Xia, Y; Yang, JD; Yao, LB; Zhang, J; Zhang, ZG | 1 |
| Cai, JK; Cui, J; Du, Q; Feng, GZ; Gu, XY; Huang, M; Shen, L; Yin, KS | 1 |
| Gao, GD; Gao, L; Li, M; Liu, YY; Qu, YZ; Wei, XY; Wu, SX; Zhao, ZW | 1 |
| Cai, JF; Chen, FR; Han, XH; Liu, P; Zhang, N; Zhang, YY | 1 |
| Cai, J; Du, Q; Gu, X; Jiang, D; Wang, Y | 1 |
| Ruan, JQ; Song, YL; Wang, YT; Yan, R; Zhou, RN | 1 |
| Chen, L; Chen, X; Gao, JQ; Li, N; Liang, WQ; Peng, LH | 1 |
| Fan, X; Shan, W; Shao, Q; Zhang, Y; Zhu, J | 1 |
| Chen, J; Chen, Y; Gui, D; Guo, Y; Huang, J; Liu, W; Wang, F; Wang, N | 1 |
| Bian, ZP; Chen, XJ; Gu, CR; Wu, HF; Xu, JD; Yang, D; Zhang, DW; Zhou, B | 1 |
| Chen, J; Li, F; Ma, J; Nan, Y; Song, T; Wang, H; Wang, W; Wang, Z; Xie, J; Yi, H | 1 |
| Bi, CW; Chen, JP; Dong, TT; Du, CY; Lau, DT; Tsim, KW; Zhan, JY; Zhang, WL; Zhao, KJ; Zheng, KY; Zhu, KY | 1 |
| Dong, N; Huang, LF; Li, JF; Li, WX; Sheng, ZY; Yao, YM; Yu, Y; Zhang, SW | 1 |
| Cao, Z; Ding, H; Li, F; Rui, Y; Tao, L; Yang, P; Zhang, W; Zhao, J | 1 |
| Chen, Y; Gan, Y; Hu, Z; Li, M; Li, S; Liu, F; She, T; Xia, H; Yu, L | 1 |
| He, Y; Jin, Y; Xi, J; Xu, Z; Zhang, Y; Zheng, H | 1 |
| Chen, P; Fu, Z; Gao, XY; Hao, M; Kuang, HY; Li, Y; Wang, Y | 1 |
| Guo, YL; Li, WJ; Yu, C; Zhang, YH; Zhang, YJ | 1 |
| Chang, YX; Gao, XM; Guo, XR; Jin, H; Li, J; Sun, YG; Zhang, BL; Zhang, QH | 1 |
| Gui, D; Guo, Y; Huang, J; Liu, W; Wang, N; Xiao, W | 1 |
| Hwang, J; Kwon, HJ; Lee, SK; Park, YD | 1 |
| Chen, J; Chen, Y; Gui, D; Guo, Y; Huang, J; Liu, X; Wang, N; Xiao, W | 1 |
| Han, C; Li, G; Li, X; Niu, Y; Wang, X; Xing, G; Zhou, L | 1 |
| Chen, X; Gao, JQ; Li, N; Li, QM; Liang, WQ; Peng, LH; Shan, YH; Wei, W; Yu, L | 1 |
| Hao, L; He, G; Huang, X; Sun, X; Zhao, J; Zhao, M | 1 |
| Cao, Y; Chen, J; Chen, X; Hu, X; Li, X; Liu, H; Lu, S; Nie, J; Wu, X; Yang, Z; Zhao, X; Zhu, J | 1 |
| Chen, F; Guo, X; Li, X; Wang, H; Wei, W; Xia, T; Zhang, Y | 1 |
| Deng, KW; He, FY; He, QP; Li, B; Liu, W; Liu, WL; Shi, JL; Wu, Y | 1 |
| Gu, Y; Niu, J; Qi, W; Qiao, Z; Qin, Q | 1 |
| Cao, LL; Li, WP; Li, WZ; Si, XL; Sun, L | 1 |
| Chen, JP; Choi, RC; Dong, TT; Luk, WK; Tsim, KW; Yao, P; Zhan, JY; Zhang, WL | 1 |
| Gao, GD; Li, LH; Li, M; Ma, RN; Qu, YZ | 1 |
| Fan, JY; Han, JY; He, K; Li, L; Li, Q; Liu, YY; Mao, XW; Mu, HN; Pan, CS; Sun, K; Tu, L; Wang, CS; Wei, XH; Yan, L; Yin, CC; Zhang, Y | 1 |
| Ju, W; Li, P; Liu, F; Xie, L; Xu, M; Yin, J; Zhang, J; Zou, C; Zou, J | 1 |
| Liu, P; Mu, Y; Ren, S; Sun, M; Zhang, H | 1 |
| Chen, WM; Shaw, LH; Tsai, TH | 1 |
| Duan, JA; Li, W; Li, Z; Shi, X; Tang, Y; Zhu, H | 1 |
| Guo, Y; Liu, G; Song, J; Wang, T; Zhou, Z | 1 |
| Du, M; Gao, Y; He, Y; Liu, H; Wang, H; Wang, Z; Wu, X | 1 |
| Chen, JD; Chen, XH; Wang, SG; Xu, Y; Yang, CH | 1 |
| Liang, L; Lu, M; Maslov, LN; Wang, H; Wang, J; Yang, J; Zhang, J | 1 |
| Gao, J; Jin, Y; Li, J; Song, J; Wang, H; Zheng, S | 1 |
| Chen, K; Feng, L; Guo, F; Huang, C; Li, Y; Liu, X; Wang, R; Wu, Y; Zhu, W | 1 |
| Cai, J; Dai, Z; Jia, Y; Li, Z; Liu, H; Pang, L; Wu, Y; Zuo, D | 1 |
| Gu, L; Mou, S; Ni, Z; Qi, C; Shao, X; Wang, Q; Xu, W | 1 |
| Du, GJ; Fan, SC; He, P; Li, ZY; Qin, XM; Zhang, FS | 1 |
| Li, G; Li, ST; Lu, ML; Wang, HX; Yang, J; Yang, YH; Zhang, J; Zhang, SP; Zhang, YJ | 1 |
| Jin, Y; Li, J; Song, J; Zheng, SR | 1 |
| Chen, MZ; Wang, B | 1 |
| Cao, J; Feng, LM; Guo, DA; Huang, FX; Lin, XH; Qiao, X; Ye, M | 1 |
| An, Y; Shi, G; Sun, X; Wu, Q; Wu, X; Zhang, M; Zhang, P | 1 |
| Kim, MH; Kim, SH; Yang, WM | 1 |
| Huang, C; Wang, PP; Wang, WP; Xu, DJ; Xu, WK | 1 |
| Choi, HJ; Kim, DH; Kim, NJ; Oh, HA | 1 |
| Li, G; Li, W; Ma, R; Sun, L; Xiong, L | 1 |
| Huang, X; Song, G; Tang, L; Wang, F | 1 |
| Feng, SL; Guo, L; Hu, F; Liu, XH; Yang, YL; Zhao, JB; Zhu, RJ | 1 |
| Chi, YF; Peng, W; Wang, L; Yin, PH; Yuan, ZT; Zhang, XM; Zhou, WC | 1 |
| Chang, CP; Chiu, BY; Hsu, YC; Lin, JW; Lin, MT; Liu, WP; Yu, JS | 1 |
| Chen, J; Chen, Y; Gui, D; He, D; Huang, J; Luo, Y | 1 |
| Cai, H; Chi, YF; Peng, W; Wang, L; Yin, PH; Yuan, ZT; Zhang, XM; Zhou, WC | 1 |
| Hu, H; Jia, N; Jin, H; Sun, Q; Wang, W; Xu, J | 1 |
| Gu, L; Mou, S; Ni, Z; Shao, X; Tian, L; Wang, L; Wang, Q; Wu, B; Xu, W; Xu, X; Yao, J; Zhang, M | 1 |
| Huang, RR; Li, WP; Li, WZ | 1 |
| Chen, L; Dai, Q; Du, J; Hu, J; Pang, W; Zhang, H | 1 |
| Le, V; Lin, S; Liu, J; Que, Z; Tian, J; Zhang, A; Zhang, L; Zheng, Y | 1 |
| Hu, J; Huo, XP; Liu, JL; Liu, QS; Ma, SH; Peng, N; Sun, AK; Wang, HF | 1 |
| Chen, J; Chen, Y; Gui, D; He, D; Luo, Y; Wang, N | 1 |
| Ammar, AB; Guo, S; Hong, Y; Shao, A; Tang, J; Tu, S; Wu, H; Zhang, J | 1 |
| Bian, T; Du, Q; Gao, F; Qian, XF; Qiu, YY; Shi, LZ; Sun, H; Yu, MH; Yuan, MY; Zhu, JX | 1 |
| Cheng, X; Gu, J; Jia, X; Jiang, J; Yuan, J; Zhang, M; Zhao, B | 1 |
| Qi, F; Song, Z; Teng, J; Yin, Y; Zhang, B | 1 |
| Li, J; Ma, J; Shi, Z; Si, J; Wang, H; Wang, N; Wang, W; Xie, J; Yang, J; Yang, L; Yi, H; Yu, S | 1 |
| Chang, CK; Chang, CP; Chiu, BY; Hsu, YC; Lin, JW; Yang, ST | 1 |
| Cheng, XD; Wei, MG | 1 |
| Ding, Y; Fang, Y; Huang, Q; Liu, Q; Liu, X; Liu, Y; Mao, P; Song, Q; Xie, P; Yuan, D; Yuan, S; Zhang, R; Zhao, C | 1 |
| Chen, X; Gao, JQ; Liu, X; Peng, LH; Shan, YH; Xiong, J | 1 |
| Cha, X; Li, D; Mao, Y; Qi, Q; Yi, J; Zhu, K | 1 |
| Chen, GQ; Gu, DM; Lu, PH; Sun, M; Wang, Q; Wang, X; Zhang, K | 1 |
| Bi, ZG; Chen, B; Chen, G; Ji, C; Jiang, HL; Li, R; Qian, W; Yan, N | 1 |
| Lu, M; Luan, A; Maslov, LN; Mei, M; Tang, F; Wang, H; Xu, C; Zhang, J; Zhang, S | 1 |
| Cheng, L; Fan, Y; Hu, G; Jia, R; Ma, X; Qiu, L; Sun, R; Tang, M; Wang, X; Xiao, W; Xing, M; Yin, G; Yu, G; Zhao, Y | 1 |
| Cho, Y; Cho, YD; Chung, DY; Hong, EK; Kang, IH; Kim, JS; Kim, S; Kim, SH; Nam, JB; Shin, JW; Sohn, NW | 1 |
| Chen, R; Gui, J; Xiong, S; Xu, W | 1 |
| Cao, YL; Chen, CF; Cheng, HX; Feng, YB; Wang, AW; Xin, W; Zhang, WW | 1 |
| Lu, M; Luan, A; Tang, F; Wang, H; Yang, J; Yang, Y; Zhang, J; Zhang, S | 1 |
| Guan, FY; Liu, J; Yang, SJ; Yang, SR | 1 |
| Chen, XH; Wang, SG; Wang, W; Xie, H; Xu, Y | 1 |
| Li, J; Miao, PP; Miao, Q; Su, J; Sun, GX; Xue, BJ; Yang, XY; Zhang, YJ; Zhao, YY | 1 |
| Han, L; Huang, YF; Li, J; Lin, X; Ma, YF | 1 |
| Chen, D; Cheng, L; Pan, JH; Wang, ZS; Xie, XH; Xiong, F | 1 |
| Feng, R; Gao, Q; Guo, F; Hao, L; Hu, H; Shao, D; Sun, X; Wang, Y; Yu, L; Zhao, M | 1 |
| Li, W; Ma, Y; Yin, Y | 1 |
| Agra, LC; Barbosa, FT; Barreto, E; Ferro, JN | 1 |
| Li, J; Li, Q; Liu, B; Liu, K; Sun, Y; Zhang, N; Zhao, W; Zhao, Y | 1 |
| Boye, A; Jiang, Y; Wang, J; Wu, C; Wu, J; Yang, X; Yang, Y | 1 |
| Frei, B; Zhang, WJ | 1 |
| Chen, B; Gao, N; He, W; Jin, H; Li, X; Shan, L; Wu, G; Yuan, H; Yuan, X; Yue, R; Zhang, W; Zhao, J | 1 |
| Cai, GJ; Chen, YF; Fan, R; Gao, Y; Hou, MX; Shi, GB; Song, J; Wang, Q; Wang, TC; Yang, C; Zhang, W | 1 |
| Hu, Y; Kong, W; Luo, H; Yang, M; Zhao, L | 1 |
| He, YX; Liu, HS; Shi, HL; Wang, ZT; Wu, H; Wu, XJ; Zhang, BB | 1 |
| Huang, J; Kang, J; OuYang, Y; OuYang, Z | 1 |
| Guo, X; Jin, Y; Li, Z; Suo, H; Xu, H; Yu, W; Yuan, B | 1 |
| Han, L; Huang, YF; Li, J; Ma, YF | 1 |
| Chen, LL; Guo, WW; Li, S; Li, YS; Lu, WS | 1 |
| Bai, Y; Chen, QF; Chen, YY; Fan, JY; Han, JY; He, B; He, K; Li, Q; Liu, YY; Lv, AP; Pan, CS; Sun, K; Wang, CS; Yan, L | 1 |
| Chen, M; Li, H; Li, X; Luo, X; Wan, H; Xia, T; Zhang, Y | 1 |
| Deng, YR; Ding, FF; Guo, LP; Sun, Y; Zhang, XJ | 1 |
| Che, X; Mou, S; Ni, Z; Shao, X; Wang, Q; Xie, Y; Xu, W | 1 |
| He, W; Li, Z; Sheng, M; Shi, J; Wang, J; Xu, L; Zhang, L | 1 |
| Dong, W; Geng, L; Li, M; Qin, A; Qin, Y; Wang, W; Zhang, M; Zhang, X | 1 |
| Jiang, W; Wang, HD; Yu, JM; Zhang, XB; Zhang, YN | 1 |
| Chen, J; Chen, X; Fu, Y; Wang, S | 1 |
| Jiang, H; Liu, R; Tian, Y; Wu, X; Zhao, W | 1 |
| Jiang, TM; Li, YM; Lu, J; Wang, Y; Zeng, S; Zhao, P | 1 |
| Bian, Z; Chen, X; Gu, C; Li, S; Lu, Y; Wu, H; Xu, J; Yang, D | 1 |
| Han, R; He, X; Hou, X; Hu, J; Lu, M; Mei, M; Tang, F; Wang, H; Xu, C | 1 |
| Chen, T; Ji, H; Jiang, W; Lu, G; Ma, Z; Ren, Y; Song, Y; Wang, H; Wang, R; Xu, A; Xu, Y; Yong, S | 1 |
| Deng, BX; Deng, CQ; Ding, H; Huang, XP; Lu, JD; Tang, YH | 1 |
| Guo, Q; Qiu, X; Tang, YQ; Xiong, W; Yang, X | 1 |
| Du, M; He, YX; Huang, F; Lan, YY; Liu, HS; Peterson, KE; Shi, HL; Wang, ZT; Woods, T; Wu, H; Wu, XJ; Zhang, BB | 1 |
| Li, F; Liu, Y; Liu, Z; Lu, L; Ou, R; Tong, Y; Wu, J; Zhang, G; Zheng, L | 1 |
| Li, J; Li, W; Liang, H; Mao, S; Yang, G; Zhang, J; Zhang, M | 1 |
| Han, R; Hu, J; Lu, M; Mei, M; Tang, F; Wang, H; Xu, C; Yang, J; Zhou, M | 1 |
| Lv, CY; Wang, CY; Wang, YZ; Xu, H; Zhang, HN | 1 |
| Dai, L; Huang, P; Lan, F; Liu, T; Liu, Y; Lu, X; Luo, X; Yin, H; Yuan, B | 1 |
| Cui, Y; Hu, JP; Li, BK; Ren, L; Wang, X; Wang, Y; Yu, S; Zhang, LD | 1 |
| Huang, H; Lai, S; Liu, J; Qi, W; Wan, Q | 1 |
| Chen, L; Gu, B; Huang, S; Zheng, J; Zhu, R | 1 |
| Liang, YP; Liu, YJ; Peng, W; Wang, H; Wang, NS; Wang, YM; Yao, WG; Yao, XM; Yu, H; Zhang, XM; Zhu, BB | 1 |
| Fu, BD; Fu, YX; Guo, X; Shen, HQ; Wei, XB; Wu, SC; Yi, PF; Zhang, C; Zhang, LY | 1 |
| Chen, Y; Cheng, X; Hu, X; Liang, J; Sun, L; Wei, B | 1 |
| Gao, Y; Hu, ZB; Huang, F; Lan, YY; Qin, LY; Shi, HL; Wu, H; Wu, XJ; Zhang, BB | 1 |
| Fu, YJ; Gai, QY; Jiao, J; Luo, M; Wang, W; Yao, LP | 1 |
| Sun, LF; Yang, H; Yu, WN | 1 |
| Dai, L; Huang, P; Liu, T; Liu, Y; Lu, X; Yin, H; Yuan, B | 1 |
| Huang, L; Li, J; Wang, S; Yao, Y; Zhang, Z | 1 |
| Hou, X; Li, L; Liu, C; Tu, M; Xu, R | 1 |
| Du, H; Han, P; Li, S; Shao, M; Song, G; Sun, H; Wang, W; Yi, T | 1 |
| Bi, S; Han, D; Li, Y; Wang, C; Yang, X; Zhang, D; Zhang, Y | 1 |
| Chang, CP; Chio, CC; Lin, HJ; Lin, MT | 1 |
| Fan, DD; Fan, YH; Gao, SN; Jiang, L; Li, S; Lin, S; Liu, B; Song, YP; Wang, ZY; Zhu, S | 1 |
| Liang, P; Zhao, XM; Zhou, NN; Zhu, R | 1 |
| Chen, C; Gong, X; Shan, G; Sun, X; Yang, Y; Yao, Q; Zhou, X | 1 |
| Bao, KF; Gui, LL; Hong, M; Jiang, GR; Liu, HL; Tao, Y; Wang, XY; Wei, X; Yu, X | 1 |
| Chen, W; Ji, Y; Jiang, K; Li, Q; Lu, Q; Xue, X | 1 |
| Ding, D; Huang, J; Lei, S; Lin, F; Liu, X; Ma, J; Mao, D; Shi, L; Zhang, S; Zhang, Y | 1 |
| Chen, XW; Dai, PC; He, CS; Jin, DH; Liu, YC; Xu, ZP | 1 |
| Deng, X; Fang, F; Li, H; Li, M; Ma, S | 1 |
| Cao, MQ; Gao, DM; Ma, DN; Qin, CD; Ren, ZG; Tang, ZY; Wang, CH; Wang, YC; Ye, BG; Zhu, XD | 1 |
| Lei, S; Xiong, S | 1 |
| Huang, J; Li, D; Li, Y; Lu, T; Nie, W; Shao, Y; Tong, L; Zhang, W; Zhu, Y | 1 |
| Dong, H; Guo, H; Liang, Y; Niu, Y; Wang, X | 1 |
| Chen, YY; Fan, JY; Han, JY; Jiang, XG; Li, C; Liu, YY; Mu, HN; Sun, K; Wang, CS; Wang, MX; Yan, L | 1 |
| Dai, J; Guo, X; Hoffman, RM; Sun, YU; Tang, D; Yang, Z; Yin, G; Zang, W; Zhang, S | 1 |
| Deng, CQ; Ding, H; Huang, XP; Li, JX; Liu, XD; Tang, B; Tang, YH; Yang, XQ | 1 |
| Li, Q; Wang, Z; Wei, D; Wen, Z; Xiang, M; Zhang, F; Zhou, Y | 1 |
| Dai, H; Jia, G; Liang, C; Lu, M; Wang, H; Wang, Y | 1 |
| Li, SL; Li, Y; Luo, HF; Xie, T | 1 |
| Wang, HL; Xu, MB; Zheng, GQ; Zhou, QH; Zhou, XL | 1 |
| Dong, M; Niu, Y; Pan, S; Yu, C | 1 |
| Chen, Y; Zhang, X; Zhou, W | 1 |
| Sun, L; Wei, XH; Xu, J; Zhong, RY; Zhou, B; Zhou, DL | 1 |
| Geng, Y; He, C; Li, L; Li, Y; Liang, X; Ma, Y; Shu, G; Song, X; Ye, G; Yin, L; Yin, Z; Yue, G; Zhang, R; Zhao, Y; Zou, Y | 1 |
| Liu, Q; Liu, Y; Wang, D; Wang, Y; Yan, X; Zhang, T; Zhao, Z; Zhong, G | 1 |
| Dai, PC; Lai, GX; Lin, XH; Liu, DL; Wang, Q; Ye, J; Zhang, HW; Zhang, L | 1 |
| Li, R; Luo, H; Yao, L; Zhang, Y | 1 |
| Guo, Q; Liu, YH; Lu, J; Lu, XC; Ma, YT; Tang, YQ; Wang, QY; Wu, Y; Zhou, Y | 1 |
| Ding, H; Dong, J; Feng, S; Hao, N; Li, J; Li, M; Li, Y; Meng, T; Ming, P; Tao, H; Wang, X; Wu, J; Zou, S | 1 |
| Cao, T; Chen, Y; Dong, Z; Peng, Y; Yuan, Z; Zhang, C | 1 |
| Cao, T; Chen, H; Dong, Z; Guo, W; Lu, R; Tian, J; Wei, H; Xu, M; Zhang, C; Zhao, P | 1 |
| Chen, D; Chen, Y; Jiang, R; Li, D; Li, J; Li, K; Li, X; Liu, Z; Wang, H; Xiong, W; Yuan, K | 1 |
| Chen, Y; Wang, L | 1 |
| Cao, T; Chen, Y; Dong, Z; Huang, G; Peng, Y; Yang, Z; Yuan, Z; Zhang, Y; Zhou, J | 1 |
| Huang, T; Li, B; Liu, N; Shen, W; Wang, F | 1 |
| Luan, JJ; Wang, L; Wang, PP; Wang, YQ; Xu, DJ; Xu, WK; Yang, CY; Zhu, YH | 1 |
| Jing, H; Liu, J; Meng, Q; Zhou, S | 1 |
| Chu, H; Dong, J; Dong, Q; Gao, Z; Huang, C; Tang, Y | 1 |
| Ding, LS; Liang, J; Peng, SL; Qing, LS | 1 |
| Cao, A; Guo, H; Peng, W; Wang, H; Wang, L; Wang, Y; Zang, Y; Zhang, X; Zhang, Y | 1 |
| Han, P; Li, S; Liu, X; Shao, M; Song, G; Sun, H; Wang, D; Wang, W; Wei, X; Wu, J; Xiong, G; Zeng, Y | 1 |
| Liang, K; Lin, SR; Ma, J; Qiao, T; Zhang, LD; Zheng, BY | 1 |
| Dai, R; Fang, Z; Huang, K; Qin, S; Yin, J | 1 |
| Dai, H; Jia, G; Leng, B; Wang, H | 1 |
| Liu, X; Qiu, J; Wang, S; Yu, C; Zhang, J | 1 |
| Chen, D; Liu, Y; Su, L; Ye, Q; Zheng, W | 1 |
| Chen, Y; Du, Y; Wan, Q; Wu, J; Xu, Y; Zhu, X | 1 |
| Gao, L; Li, H; Min, J; Yang, Y; Zhang, R; Zhang, Y | 1 |
| Fei, Z; Hu, T; Wei, N | 1 |
| Chai, XQ; He, KQ; Jiang, Y; Li, WP; Li, WZ; Yin, YY | 1 |
| Deng, CQ; Huang, XP; Li, JX; Liu, XD; Tang, B; Tang, YH; Yang, XQ | 1 |
| Fan, CL; Qiao, Y; Tang, MK | 1 |
| Bian, ZP; Chen, XJ; Ding, YZ; Gu, CR; Li, XZ; Wu, HF; Xu, JD; Yang, D | 1 |
| Li, C; Li, D; Liu, F; Yang, F; Yang, T | 1 |
| Huang, F; Jin, J; Li, H; Shi, H; Wang, P; Wang, Z; Wu, H; Wu, X; Zhang, B | 1 |
| Tan, HY; Tang, B; Wei, XQ; Zhang, JG | 1 |
| Chen, H; Li, Y; Ye, Y | 1 |
| Chang, TC; Chang, WL; Huang, SF; Kirkby, NS; Lee, SY; Li, ZX; Ou, CH; Tsai, WC | 1 |
| Wen, K; Zhu, J | 1 |
| Dou, L; Gao, H; Li, W; Shan, L; Sun, Y | 1 |
| Fang, ZH; Lin, YX; Shen, GM; Wang, TT; You, LZ; Zhao, JD | 1 |
| Deng, KW; He, FY; Liao, Q; Liu, WL; Tang, Y; Xiao, MF; Yang, YT; Zhang, YT; Zhou, YQ | 1 |
| Bi, Y; Jiang, P; Li, X; Ma, D; Wang, X; Wang, Y; Yang, J | 1 |
| Dai, RZ; Gao, F; Li, JS; Zhang, DQ; Zhang, YM | 1 |
| Cai, SQ; Wang, D; Xu, F; Ye, J; Zhang, WW | 1 |
| Cai, D; Cai, T; Chen, Y; Gan, H; Huang, X; Li, S; Pan, H; Zeng, X; Zhang, C; Zhao, Z; Zhuo, J | 1 |
| Jia, XT; Pan, YF; Peng, XZ; Song, EF | 1 |
| Hu, N; Hu, X; Hu, Y; Qiu, Y; Song, Z; Zhou, L | 1 |
| Deng, KW; He, FY; Liu, WL; Xiao, MF; Yang, YT; Zhang, YT; Zhou, J; Zhou, YQ | 1 |
| Guo, Y; Ji, Y; Li, L; Wang, T; Wang, Y; Yang, B; Zhang, X; Zhu, T | 1 |
| Cui, L; Mou, J; Wang, S; Wang, X; Zhang, Z | 1 |
| Cai, D; Cai, H; Cai, T; Chen, X; Li, S; Liu, W; Pan, H; Xie, K; Yan, Y; Zeng, X; Zhang, C; Zhao, Z | 1 |
| Lei, X; Luo, FL; Ren, JG; Zhang, BD | 1 |
| Liu, HB; Liu, ZH; Wang, J | 1 |
| Deng, J; Ma, SP; Ma, ZQ; Ruan, J; Song, MT; Zhang, RY | 1 |
| Dong, TTX; Huang, Y; Kong, XP; Kwan, KKL; Leung, KW; Tsim, KWK; Wang, H | 1 |
| Ge, N; Han, P; Li, S; Shao, M; Song, G; Sun, H; Wang, D; Wang, W; Yi, T; Yi, W; Yu, X | 1 |
| Qi, R; Tuerdi, N; Wan, Y; Wang, Y; Xu, L; Ye, M | 1 |
| Chang, C; Leying, Z; Meiqian, Z | 1 |
| Cai, X; Qian, Q; Qian, W; Wang, D; Zhang, W | 1 |
| Cui, HJ; Lin, XP; Luo, JK; Tang, T; Yang, AL | 1 |
| Ma, Y; Qiao, G; Yin, Y; Yu, X; Yu, Y; Zhang, Y | 1 |
| Chen, X; Gao, Z; Lv, Z; Yang, X; Yu, W; Zhang, L; Zhong, M | 1 |
| Leng, B; Lu, M; Tang, F; Wang, H; Zhang, Y; Zhang, Z | 1 |
| Ding, Y; Huang, W; Ji, L; Li, L; Liu, C; Sun, K; Tumen, B; Wang, S; Zhang, L; Zhang, W | 1 |
| Gao, Y; Shi, Y; Tian, N; Wang, X; Zhang, N; Zou, D | 1 |
| Jia, L; Lv, D; Wang, Z; Zhang, S; Zhou, B | 1 |
| Cui, J; Cui, WQ; Dong, JC; Gong, WY; Hu, LL; Liu, BJ; Qiu, J; Wei, Y; Xu, F | 1 |
| Dong, H; Hu, Z; Huang, F; Lan, Y; Qin, L; Shi, H; Wu, H; Wu, X; Zou, Q | 1 |
| Huang, L; Ji, C; Lu, Z; Luo, Y; Tian, R; Zou, C | 1 |
| Pan, H; Rui, R; Sun, B; Wang, X; Zhang, L | 1 |
| Alves, RD; Cavalcante, JS; Cavalcanti, JRLP; Costa, IM; Fernandes, LCB; Filho, IA; Freire, MAM; Guzen, FP; Lima, FOV; Lucena, EES; Neta, FI; Norrara, B; Queiroz, DB; Rego, ACM | 1 |
| Chen, J; Dai, Q; Ding, L; Gu, Q; Guo, X; Li, M; Liang, M; Liu, C; Liu, P; Luo, X; Wen, W; Zheng, X | 1 |
| Lei, X; Li, Z; Ren, J; Zhang, L | 1 |
| Guo, Z; Liu, Z; Lou, Y; Lu, L; Qi, X; Wang, Y; Wu, J; Zhang, G; Zhu, Y | 1 |
| Chen, Q; Ju, Y; Li, W; Ma, K; Su, Y | 1 |
| Gao, Y; Tian, N; Wang, T; Wang, X; Wu, B; Xu, J; Zhang, N; Zhu, Z | 1 |
| Chang, H; Gong, L; Guo, G; Shi, J; Xu, H; Zhang, J | 1 |
| Chen, PJ; Shang, AQ; Wang, WW; Yang, JP | 1 |
| Jiranusornkul, S; Nimmanpipug, P; Saenjum, C; Sirithunyalug, B; Wongrattanakamon, P | 1 |
| Chen, L; Chen, TB; Ding, LS; Luo, P; Qing, LS; Sun, WX; Zhang, ZF | 1 |
| Kan, P; Wang, J; Xiang, L; Xu, N; Yang, P; Yao, X; Zhu, Y | 1 |
| Chen, Q; Ji, T; Ju, Y; Li, W; Ma, K; Su, Y; Wang, Z | 2 |
| Cao, X; Du, N; Gao, M; Liu, P; Sun, B; Xu, Z | 1 |
| Liu, Y; Sun, P; Wang, Q; Zhang, B | 1 |
| Cheng, X; Ge, D; Qi, B; Wang, S; Zhang, Z | 1 |
| Chen, X; Chen, Z; Liu, C; Wang, D; Yang, Y | 1 |
| Jiao, S; Li, Y; Liu, B; Yang, Y; Zhang, J; Zhang, X; Zhao, Y | 1 |
| Bian, Y; Chen, J; Chen, L; Chen, Y; Pan, Y; Shen, Y; Song, Z; Wei, D | 1 |
| Cao, Y; Guo, LH; Han, Y; Li, J; Zhuang, RT | 1 |
| Dong, S; Guan, Y; Wang, L; Wang, Y; Wu, X; Yang, S; Zhao, Y | 1 |
| Gong, Z; Hu, H; Jin, G; Kang, X; Yin, F; Zhang, L; Zhang, X; Zheng, J | 1 |
| Fang, Z; He, Y; Hu, M; Jiang, A; Lin, Y; Liu, M; Shen, G; Wang, L; Wang, Q; Ye, S; You, L | 1 |
| Ma, Y; Xiong, L | 1 |
| Cheng, Y; Ding, LS; He, Y; Luo, P; Qing, LS; Sun, WX; Xie, J; Zhang, ZF | 1 |
| Chen, L; Chen, S; Deng, L; Huang, Y; Li, C; Tian, M; Wang, F; Zhou, X | 1 |
| Gao, Y; Shi, Y; Tian, N; Wang, T; Wang, X; Wu, B; Xu, J | 1 |
| Cao, M; Chen, L; Chen, S; Li, C; Sun, L; Wang, F; Zhao, Y; Zhou, X | 1 |
| Chang, D; Huang, J; Liu, J; Ma, B; Xue, B; Yang, B | 1 |
| Huang, F; Lan, Y; Li, H; Liu, M; Shi, H; Wu, H; Wu, X; Yang, L; Zhang, B; Zhang, W | 1 |
| Gao, H; Qu, X; Song, Y; Sun, J; Tao, L; Zhai, J; Zhang, S; Zhang, Y | 1 |
| Bai, F; Lin, X; Qi, M; Sun, S; Wang, Q; Wu, Q; Xu, G; Yu, J | 1 |
| Chang, X; Xia, Q; Yang, P; Yao, L; Zhou, Y | 1 |
| Huang, H; Nie, C; Qin, X; Zhang, L; Zhou, J | 1 |
| Li, J; Zhang, X; Zhu, Z | 1 |
| Liu, F; Liu, L; Sui, YB; Wang, Y; Zhang, YQ | 1 |
| Jiang, X; Lei, L; Li, A; Li, J; Mehmood, K; Qamar, H; Wang, Y; Waqas, M; Yao, W; Zhang, H; Zhang, L | 1 |
| Liang, Y; Niu, C; Niu, Y; Zou, Y | 1 |
| Cheng, L; Han, M; Wei, H; Wu, P; Yang, LM | 1 |
| Chen, D; Chen, J; Chen, X; Cheng, S; Feng, Q; Shen, L; Sun, W; Yang, L; Yu, P; Zhang, H; Zhang, X | 1 |
| Deng, S; Zhang, L | 1 |
| Du, J; Leng, JY; Liu, J; Yang, ST; Zhen, J; Zheng, EL | 1 |
| Wang, F; Yang, X | 1 |
| Deng, CQ; Tang, B; Tang, WJ; Tang, YH | 1 |
| Chen, X; He, H; He, M; Luo, Y; Wan, Q; Xu, M; Yin, D; Zhou, Q | 1 |
| Fang, L; Li, H; Li, Z; Lin, J; Lyu, L; Wang, H; Xiao, J | 1 |
| Dong, Y; Liu, J; Liu, T; Liu, X; Ma, R; Niu, H; Sun, J; Wang, Y; Xiao, Y; Xiao, Z; Yang, F; Zhang, M | 1 |
| Meng, F; Nie, P; Shen, C; Wei, X; Zhang, J | 1 |
| Ding, Q; Gao, J; Jing, S; Wang, A; Zheng, J | 1 |
| Leng, B; Nie, Q; Wang, H; Zhang, L; Zhu, L | 1 |
| Chang, XC; Li, GW; Wang, F; Yang, P; Zhou, YP | 1 |
| Cao, QW; DU, J; Li, AP; Li, K; Liu, YT; Luo, JP; Qin, XM; Zhang, R | 1 |
| Chen, Y; Huang, S; Le, B; Li, S; Li, W; Mo, Y; Pan, H; Wang, Q; Wang, S; Wei, R; Wen, H; Xu, E; Yang, C; Zheng, J | 1 |
| Jiang, W; Liu, L; Xie, D; Xie, H; Zhang, L; Zhou, P | 1 |
| Cai, X; Qian, Q; Qian, W; Yang, W; Zhang, X; Zhao, L; Zhuang, Q | 1 |
| Gao, K; Wang, X; Zhang, X; Zhu, W | 1 |
| Feng, F; Li, N; Wang, W; Wu, K; Zhang, H; Zhang, W | 1 |
| Gai, X; Jiang, Y; Wei, D; Xu, H | 1 |
| Li, M; Wang, H; Zhang, X | 1 |
| Liu, B; Ma, Y; Wang, Y; Zhang, H; Zhao, H | 1 |
| Chai, Z; Cungen, M; Guo, M; Li, Y; Liu, C; Wang, Q; Yan, Y; Yu, J; Zhang, G; Zhang, H | 1 |
| Shi, D; Xing, B; Yang, F; Zhang, P; Zhang, R; Zhang, X; Zhao, J | 1 |
| Fang, Y; He, Y; Li, C; Wan, H; Yang, J; Yin, F; Yu, L; Zhou, H | 1 |
| Chen, X; Gao, W; Gu, M; Hu, S; Huang, C; Lin, H; Lin, J; Pan, X; Shao, Z; Tian, N; Wang, B; Wang, X; Wu, Y; Zhang, X; Zheng, X; Zhou, Y | 1 |
| Wang, H; Wang, J; Zhang, H; Zhang, Z; Zhu, Y | 1 |
| Huang, J; Jin, Z; Li, J; Lin, X; Luo, J; Qian, X; Zhu, Y | 1 |
| Feng, K; Tang, Y; Tao, R; Wei, Y; Wu, Y; Xu, H; Zhao, Y | 1 |
| Fan, H; Fan, Y; Li, P; Liu, Q; Zhou, Y; Zhu, B | 1 |
| Cheng, H; Jiang, F; Liu, Y; Song, E; Tan, X; Wang, Y; Wei, C | 1 |
| Dang, WZ; Feng, GZ; Hu, XG; Jiang, B; Li, H; Shen, XY; Yang, YJ; Yu, XC | 1 |
| Huang, H; Liu, W; Xu, Z | 1 |
| Ding, L; Geng, L; Hu, X; Li, M; Wang, Z; Xie, S; Yang, T | 1 |
| Liang, YN; Niu, YC; Zhang, J; Zhao, XM | 1 |
| Chen, DA; Cheng, CS; Cheng, JL; He, F; Huang, YF; Lao, CC; Luo, P; Ma, HL; Sang, Z; Wang, CJ; Wang, YP; Xiao, SY; Xie, Y; Zhang, ZF; Zhou, H | 1 |
| Bai, XH; Chen, JK; Chen, LQ; Guo, MK; Li, JQ; Li, L; Su, SM | 1 |
| Chen, CX; Dai, L; Ding, LS; Feng, HY; Guo, K; Qing, LS; Wang, L; Xie, J | 1 |
| Chen, YL; Hsieh, HL; Huang, CY; Liu, SH; Wu, SJ | 1 |
| Han, X; Hu, Z; Huang, F; Shi, H; Wu, H; Wu, X; Xing, F; Yang, L; Yuan, J; Zhang, T | 1 |
| Du, G; Gao, L; Qin, X; Wu, C; Zhang, J | 1 |
| Feng, J; He, Y; Jie, Z; Mei, Z; Ren, L; Shi, T; Song, Z; Zhang, H; Zhang, J; Zhang, W | 1 |
| Chen, HY; Chen, WC; Chen, YH; Liu, PL | 1 |
| Han, J; Shen, X; Wang, S; Zhang, Y; Zhou, L | 1 |
| Cai, X; Qian, Q; Qian, W; Tian, L; Zhang, W | 1 |
| Dong, F; Liu, Z; Mei, X; Qiao, Y; Wang, S; Wang, Y; Wang, Z; Zhang, J | 1 |
| Huang, S; Liu, X; Wan, J; Zang, Y; Zhang, W; Zhang, Z | 1 |
| Ji, T; Li, W; Wang, Z; Zhang, J; Zhang, Y; Zhu, Y | 1 |
| Ding, JH; Du, RH; Hu, G; Xia, ML; Xie, XH | 1 |
| Gao, H; Hu, T; Qu, X; Song, Y; Sun, J; Tao, L; Zhai, J; Zhang, Y | 1 |
| Cai, Y; He, Z; Xia, C | 1 |
| Chen, YJ; Duan, WJ; Liang, L; Ma, XH; Xu, NG; Yang, JJ; Zhang, XH | 1 |
| Chen, Y; Han, M; Jiang, S; Jiao, G; Liu, W; Wang, X | 1 |
| Ding, R; Fang, H; Ge, R; Huang, J; Wang, E; Wang, J; Wang, L; Wang, T; Zhai, M; Zhou, P | 1 |
| Chen, Z; Cui, J; Fan, Z; Guo, B; Hu, J; Liu, Y; Shen, J; Wang, Y; Wu, Y; Xie, L | 1 |
| Chu, W; Ding, Y; Jiang, C; Liu, X; Ma, L; Shang, S; Shao, B; Wang, J; Zhang, S | 1 |
| Guo, Y; Jin, Y; Li, L; Wei, J; Zhao, Y | 1 |
| Cui, X; Jiang, X; Tong, G; Wei, C; Xing, Y | 1 |
| Jia, L; Liang, C; Ni, GX; Shi, XL; Wang, YL | 1 |
| Ge, B; Li, FR; Li, SL | 1 |
| Feng, JX; Li, HY; Li, JC; Liao, XM; Meng, P; Su, YY; Wang, LN; Wang, S; Wang, YN; Zhang, YF; Zhao, SL | 1 |
| Ge, Y; Gou, J; He, H; Kong, J; Shang, L; Sun, R; Tang, X; Tao, X; Wang, Y; Yin, T; Zhang, A; Zhang, G; Zhang, Y | 1 |
| Dong, X; Yang, L; Zhang, W | 1 |
| Deng, LL | 1 |
| Liu, J; Qu, Q; Song, C; Sui, X; Sun, L; Wang, T; Zhang, Z | 1 |
| Chen, H; Dou, R; Han, C; He, Q; Hu, J; Huang, L; Lin, H; Ren, D; Yang, H | 1 |
| Duan, CQ; Liang, C; Ni, GX; Wang, J; Wang, P; Wang, YL | 1 |
| Chen, Y; Niu, Y; Wang, Q; Xu, H; Xue, C; Zhao, RC; Zhu, R | 1 |
| Bo, A; Li, M; Li, Z; Liu, L; Yang, M; Zhang, C | 1 |
| Bai, L; Chen, D; Chen, J; Li, H; Li, J; Lin, H; Liu, B; Lu, R; Pang, Y; Wu, J; Zhang, P; Zhou, J; Zhou, Y | 1 |
| Chen, H; Li, W; Wang, X; Xu, W; Zhu, G | 1 |
| Li, D; Qiao, Y; Qin, X; Wei, Q; Xue, X; Zhang, F; Zhang, J | 1 |
| Chen, H; Guo, Q; He, Y; Li, Y; Zhang, L; Zhang, Q; Zhang, Z | 1 |
| Guo, J; Tang, C; Wang, Y; Yu, J; Zhou, J; Zhu, W | 1 |
| Cao, W; Jiang, J; Tao, C; Xuan, C; Zhang, Y | 1 |
| Dong, TT; Gong, G; He, H; Qi, B; Tsim, KW; Yin, T; Yu, H; Zheng, Y | 1 |
| Song, L; Xing, B; Yang, S; Zhang, P; Zhang, R; Zhou, L | 1 |
| Baak, J; Brede, C; Kafle, B | 1 |
| Li, X; Liu, J; Niu, Y; Yu, C; Zhang, J | 1 |
| Ao, C; Chen, X; Gong, DY; Ma, YR; Zhou, XT; Zou, JJ | 1 |
| Chen, HW; Li, J; Tan, YQ | 1 |
| Abulikemu, Z; Aierken, R; Dilixiati, N; Huang, Y; Li, XY; Sui, S; Tuerxun, D; Zhang, YM | 1 |
| Chen, L; He, H; Liu, F; Ran, F | 1 |
| Arunagirinathan, N; Divyadarshini, A; Indu, P; Rajarajan, S; Rameshkumar, MR; Sangeetha, K | 1 |
| Gao, H; Gong, J; Hu, T; Li, Z; Qu, X; Song, Y; Sun, J; Tao, L; Zhai, J; Zhang, Y | 1 |
| Tang, B; Tang, WJ; Wang, LL; Zhou, X | 1 |
| Dou, B; Gao, J; Liu, XL; Sun, NY; Wu, XH | 1 |
| Hu, S; Jin, L; Zheng, W | 1 |
| Jin, S; Liu, X; Promes, V; Tian, Y; Zhang, Y | 1 |
| Liu, L; Liu, Y; Ren, YK; Sui, YB; Zhang, KK | 1 |
| Duan, J; Han, X; Song, Q; Yang, Y; Zhao, Y | 1 |
| Lu, M; Sun, T; Sun, Y; Wang, H | 1 |
| Gao, S; Liu, J; Liu, M; Song, L; Sun, Z; Wang, X | 1 |
| Chen, K; Dou, B; Ke, Z; Li, S; Wang, L; Wang, Z; Wei, L; Zhu, S | 1 |
| Huang, D; Pei, C; Wang, F; Wang, M; Wang, X; Wang, Z; Wu, Y; Xiao, W | 1 |
| Dong, YJ; Du, SJ; Gao, WJ; Tang, JL; Zhang, Y; Zhao, YM; Zhou, XH | 1 |
| Guo, L; Jiao, Y; Jin, H; Kim, SC; Li, X; Liu, J; Ma, Y; Shen, L; Zhao, R; Zhou, Z | 1 |
| Chu, L; Fang, Y; Gan, H; Hu, X; Jin, H; Li, L; Yang, Y; Zhang, J | 1 |
| Dai, LG; Dai, NT; Fu, KY; Hsieh, PS; Huang, NC; Kang, LY | 1 |
| Deng, Y; Lin, N; Liu, S; Liu, Z; Shao, X | 1 |
| Du, J; Jin, H; Ren, H; Wang, W; Yang, G | 1 |
| Feng, F; Li, N; Wang, L; Wang, W; Wu, K; Zhou, X | 1 |
| Chen, T; Jia, Y; Yang, P | 1 |
| Cao, Y; Li, Y; Lv, Q | 1 |
| Guan, Z; Li, Y; Lu, Y; Pei, B; Sun, D; Wang, X; Xu, J; Yuan, L; Zhang, X | 1 |
| Chen, J; Fang, J; Huang, J; Wang, H; Wang, L; Wang, Y; Xing, L; Yao, X; Zhu, B | 1 |
| Cai, J; Fu, Y; He, Y; Xi, J; Xi, M; Zhang, Y; Zhao, Y; Zheng, Y | 1 |
| Chu, D; Hu, C; Liu, X; Ma, X; Wang, B; Yu, T; Zhang, C | 1 |
| Chen, BJ; Han, SS; Hou, J; Liu, FY; Sun, CB; Wen, J; Xiong, L; Yan, JY; Yang, ZS; Ying, Y; Yu, JZ; Zhang, SQ | 1 |
| Gao, Y; Jiang, C; Lin, Y; Shan, H; Wang, N; Xia, W; Yin, F; Yu, X; Zhou, L; Zhou, Z | 1 |
| Cao, A; Deng, W; Li, Z; Liu, S; Peng, W; Shan, X; Wang, H; Wang, L; Wang, Y; Zang, Y | 1 |
| Chen, LM; Feng, WH; Gao, HM; Guo, ZY; Li, C; Liang, YH; Liu, XQ; Meng, CX; Wang, ZM; Yan, LH; Zhu, JJ | 1 |
| Jiang, J; Li, Y; Liu, P; Ma, Y; Meng, C; Shi, R; Wang, T; Wang, Y; Wu, J; Yuan, W; Zeng, J; Zhang, H; Zhong, J; Zhu, L | 1 |
| Guan, P; Ji, ES; Luo, LF; Qin, LY; Wang, JX; Wang, N | 1 |
| Abd Elkader, HAE; Abdou, HM; Essawy, AE; Khamiss, OA | 1 |
| Hu, CQ; Li, YX; Liu, XZ; Ma, XF; Wang, BS; Zhang, CY | 1 |
| Han, D | 1 |
| Hu, X; Li, W; Song, Y; Sun, X; Tang, F; Wang, H; Wang, Q; Xie, X; Yang, X; Zhang, L; Zhao, N; Zhuang, R | 1 |
| Han, Z; Zhu, J | 1 |
| Cao, W; Chen, Z; Chu, L; Ma, S | 1 |
| He, RH; Liu, XD; Ma, FZ; Ma, Q; Wang, J; Zhang, B | 1 |
| He, Y; Li, W; Shao, C; Wan, H; Yang, J | 1 |
| Dong, X; Han, Y; Li, W; Li, Y; Su, Y; Zhang, J; Zhang, Y; Zhu, Y | 1 |
| Jiang, J; Wei, K; Xu, L; Zhang, L | 1 |
| Chai, YH; Chen, YZ; Gao, J; Jiang, ZB; Li, W; Luo, YF | 1 |
| Chai, Y; Kang, Q; Kong, L; Qian, H; Wang, F; Wang, W; Wang, X; Xu, J; Xu, Z | 1 |
| Cui, X; Fan, C; Jiang, H; Liu, J; Lu, Y | 1 |
| Gao, G; Liu, PP; Shi, H; Song, R; Wang, L; Wang, SS; Yin, G; Zhou, P; Zou, YY | 1 |
| Jeong, HY; Jung, EG; Kim, WJ; Lee, GS; Lee, YS; Nam, KW; Seo, YR; Yang, HG | 1 |
| Chen, H; Liu, W; Wang, D | 1 |
| Fang, C; Fang, F; Jin, F; Li, W; Wang, H; Wang, J; Wang, S | 1 |
| Hayashi, S; Kadowaki, M; Yamamoto, T; Zhang, Y | 1 |
| Chen, S; Jia, D; Lei, Y; Li, Y; Luo, Z; Wang, Y; Xia, F; Xu, G; Xue, M; Zhu, L | 1 |
| Guo, LH; Huang, X; Liu, B; Ma, SY; Yin, X; Zhang, MZ | 1 |
| Chen, F; Cheng, XY; Li, J; Liu, HT; Wang, R; Yang, D; Yang, H; Yang, XH; Yao, Y; Zheng, P | 1 |
| Chen, F; Chen, X; Gong, P; Liu, N; Shi, F; Wang, L; Wang, S; Xiao, X; Yang, W | 1 |
| Liu, L; Meng, Q; Yan, D; Yang, CJ; Zhang, L; Zhang, X; Zhang, Y | 1 |
| Guo, J; Xu, S | 1 |
| Cai, R; Chen, M; Li, G; Li, L | 1 |
| Chen, IY; Kuo, YC; Rajesh, R | 1 |
| Fang, Z; Gao, R; Qu, H; Yang, Q; Yin, Y | 1 |
| Cao, Y; Gao, F; Wang, J; Wang, X; Xu, W; Zhu, G | 1 |
| Du, J; Hu, D; Li, H; Liu, Z; Shi, K; Yao, C; Zhao, Y | 1 |
| Feng, W; Li, Y; Sun, H; Xue, Y; Yang, J; Zhang, J | 1 |
| Deng, CQ; Ding, H; Huang, XP; Liu, XD; Tang, S; Yang, XQ; Zeng, XB; Zhu, QY | 1 |
| Chen, W; Fan, X; Gao, S; Huang, C; Jiao, G; Qiu, S; Sun, M; Tao, X; Weng, N; Zhang, F; Zhou, X | 1 |
| Kasetti, RB; Kodati, B; Maddineni, P; Nagarajan, B; Yacoub, S | 1 |
| Guo, J; He, Q; Jiang, F; Lu, X; Meng, P; Yang, R; Yang, T | 1 |
| Li, J; Liu, H; Ren, X; Shao, J; Wang, X; Xu, L; Xu, M; Zhang, W | 1 |
| Wang, B; Wang, L; Xiong, F; Yang, L; Zhou, G | 1 |
| Cui, SN; Huo, Q; Li, CC; Wang, MY; Zhang, TF; Zhang, TQ | 1 |
| He, Y; Huang, D; Li, S; Pei, C; Shi, S; Wang, F; Wang, M; Wang, X; Wang, Y; Wang, Z; Wu, Y; Xiao, W | 1 |
| Chen, B; Chen, J; Hou, J; Li, J; Liu, S; Lu, S; Mei, Y; Shen, Z; Tang, Y; Wang, W; Zhang, L; Zhang, M | 1 |
| Chen, T; Gao, X; Li, S; Li, Z; Wang, Z; Zou, Y | 1 |
| He, YH; Hu, XD; Liu, A; Lu, HY; Xu, SY; Yang, ZL | 1 |
| Li, WT; Li, YJ; Qin, HW; Wang, Y; Zhang, QS | 1 |
| Guo, H; Wu, C; Zhao, J | 1 |
| Li, X; Mo, Y; Wang, J; Wang, W; Xiao, X; Zheng, Y | 1 |
| Li, Z; Liu, Y; Luo, P; Wu, J; Yang, W; Yang, Y | 1 |
| Chang, X; Fan, JY; Han, JY; He, K; He, SY; Hu, BH; Lin, SQ; Liu, YY; Pan, CS; Wei, XH; Yan, L; Zhao, XR | 1 |
| Ma, K; Pan, T; Tian, H; Wang, S; Wang, T; Yao, S; Yu, H; Zhang, Y | 1 |
| Britza, SM; Byard, RW; Musgrave, IF | 1 |
| Cao, K; Li, F; Liu, Y; Wang, M; Zhang, Y | 1 |
| He, Y; Huang, D; Pei, C; Shen, Z; Shi, S; Wang, M; Wang, X; Wang, Y; Wang, Z; Wu, Y | 1 |
| Fan, H; Fan, Y; Huang, L; Li, P; Liu, Q; Zhou, Y | 1 |
| Bai, X; Hu, W; Liang, Y; Lin, X; Xiao, H; Xiong, W; Zhu, C; Zou, X; Zou, Y | 1 |
| Bao, XX; Feng, JJ; Liu, H; Yang, Y; Yu, H; Yu, YY; Zhao, J | 1 |
| Dai, A; Li, C; Li, G; Li, S; Meng, F; Wu, S; Zha, J; Zhang, S; Zhu, H; Zhu, L | 1 |
| Li, C; Li, J; Lian, Y; Liu, Q; Meng, L; Shi, W; Wu, M; Xie, Y | 1 |
| Cao, WF; Chen, ZW; Du, XQ; Hu, JY; Shi, LP; Xiong, Y; Zuo, B | 1 |
| Hu, Y; Hu, Z; Liu, W; Pan, C; Tang, W | 1 |
| Fan, X; Li, R; Zhang, S; Zheng, Y; Zhou, Y | 1 |
| Li, Y; Liu, D; Liu, W; Wan, Q; Xiao, Q; Xiong, Y; Zhao, H; Zhong, Y; Zhou, W | 1 |
| Cheng, Y; Lin, H; Xiang, Z; Xiao, Q; Yu, X | 1 |
| Ping, S; Rongjia, Z; Xiaotong, Z; Xiuping, Y | 1 |
| DU, GH; Li, HJ; Luo, YY; Qin, XM; Zhang, FS; Zhang, JQ; Zhang, X | 1 |
| Tang, JL; Xin, M; Zhang, LC | 1 |
| Cheng, Y; Tao, F; Wang, A; Wei, W; Wei, Z; Xu, Y; Yang, G; Yin, X; Yu, Y; Zhang, L; Zhang, X; Zhu, X | 1 |
| Fan, J; Jia, F; Liu, Y; Zhou, X | 1 |
| Fukami, H; Kishino, S; Ogawa, J; Ozeki, Y; Takeuchi, DM | 1 |
| Feng, Y; Gao, X; Hao, X; Li, L; Long, Y; Zhang, J; Zhang, S; Zhang, X | 1 |
| He, Z; Hong, L; Li, H; Xu, J; Zeng, Z; Zhang, L; Zhang, Y | 1 |
| Gao, ZC; Kang, DF; Kong, XL; Li, C; Li, YL; Liu, XX; Lyu, Q; Wu, JB; Zhang, L; Zhang, YQ | 1 |
| Chen, D; Feng, M; Guo, H; Lv, J; Su, L; Tu, Y; Wang, Z; Zhang, C | 1 |
| Chen, BY; Chen, CH; Liou, JC; Wu, JL; Yang, SL | 1 |
| Du, Y; He, Y; Li, C; Wan, H; Xu, S; Yang, J | 1 |
| Huang, D; Pei, C; Shen, Z; Shi, S; Wang, F; Wang, X; Wang, Y; Wang, Z; Wu, Y | 1 |
| Han, X; Shu, Z; Tang, J; Wang, Y; Yu, L | 1 |
| Guan, L; Jiang, J; Liu, H; Liu, J; Peng, L; Qiao, Y; Yan, X; Zhai, Y; Zhang, Z; Zhou, W | 1 |
| Jin, J; Li, P; Li, Z; Lin, Y; Zhang, H | 1 |
| Guo, L; Guo, Q; Huang, X; Ma, M; Su, Y; Yin, X | 1 |
| He, Y; Huang, B; Huang, J; Meng, Y; Shen, F; Wang, L | 1 |
| Peng, W; Qiu, F; Yu, S; Zhang, G | 1 |
| Guo, T; Li, J; Zhou, R | 1 |
| Feng, XC; Jiang, CY; Ren, NQ; Shi, HT; Wang, WQ; Wang, YM; Xiao, ZJ; Xu, YJ; Yuan, Y; Zhang, X | 1 |
| Wang, L; Yao, M; Zhang, L | 1 |
| Li, L; Li, Y; Luo, Y; Meng, X; Pan, G; Zhang, B; Zhang, H; Zhang, Y | 1 |
| Kang, Z; Tang, B; Wang, L; Xiao, L; Xiao, Q | 1 |
| Bai, G; Cheng, C; Hou, Y; Li, S; Liu, K; Shen, F; Xie, Y; Zhang, J | 1 |
| He, Y; Kai, G; Lin, X; Liu, J; Liu, L; Liu, N; Xu, Z; Yao, J | 1 |
| Gao, Y; Su, X; Xue, T; Zhang, N | 1 |
| Deng, CQ; Ding, H; Huang, MT; Huang, XP; Li, Y; Li, YL; Liu, CX; Liu, XD; Tang, S; Xiong, HL; Zhang, W | 1 |
| Chen, M; Du, W; Wang, J; Wen, F; Wu, S; Zhong, X | 1 |
| Cao, X; Dai, A; Tan, J; Wang, F; Xie, S; Yi, J | 1 |
| Bade, R; Bao, M; Borjigidai, A; Cheng, Y; Liu, H; Shao, G; Tsambaa, B | 1 |
| Chen, B; Dou, G; Gan, H; Gu, R; Liang, D; Liang, Y; Liu, S; Meng, Z; Quan, X; Sun, Y; Wu, Z | 1 |
| Hao, J; Liu, H; Qiao, S; Shi, J; Wang, L; Wu, J; Xie, C; Yu, Y; Zheng, X | 1 |
| Chen, Z; Liu, H; Luo, S; Sha, X; Yang, D | 1 |
| Chongming, A; Tingxin, L; Xirong, H; Ziyang, T | 1 |
| Guo, M; Kumar, G; Liu, C; Ma, C; Meng, T; Mu, B; Song, L; Yan, Y; Yu, J | 1 |
| Cheng, Z; Feng, J; Guo, H; Li, P; Liu, B; Qin, W; Shao, S; Wan, M; Xu, Z; Xue, W; Zhang, Y; Zhou, H | 1 |
24 review(s) available for astragaloside a and beta-escin
| Article | Year |
|---|---|
[Recent development of chemical studies on some medicinal plants of Astragalus spp].
Topics: Chemical Phenomena; Chemistry; Drugs, Chinese Herbal; Glucosides; Glycosides; Sapogenins; Saponins; Triterpenes | 1988 |
Pharmacological effects of Astragaloside IV: a literature review.
Topics: Animals; Astragalus propinquus; Drugs, Chinese Herbal; Humans; Phytotherapy; Saponins; Triterpenes | 2013 |
Triterpenes with healing activity: A systematic review.
Topics: Cell Movement; Cell Proliferation; Collagen; Fibroblasts; Ginsenosides; Humans; Keratinocytes; Pentacyclic Triterpenes; Reactive Oxygen Species; Sapogenins; Saponins; Skin; Skin Diseases; Triterpenes; Ursolic Acid; Wound Healing | 2015 |
Research review on the pharmacological effects of astragaloside IV.
Topics: Animals; Astragalus propinquus; Drugs, Chinese Herbal; Gene Expression; Humans; Molecular Structure; Oxidative Stress; Protective Agents; Saponins; Triterpenes | 2017 |
Astragaloside IV for Experimental Focal Cerebral Ischemia: Preclinical Evidence and Possible Mechanisms.
Topics: Amino Acid Sequence; Animals; Brain Ischemia; Drug Evaluation, Preclinical; Models, Molecular; Publication Bias; Saponins; Stroke; Treatment Outcome; Triterpenes | 2017 |
[Research advances on astragaloside-IV in treatment of diabetes mellitus and its complications pharmacological effects].
Topics: Animals; Astragalus propinquus; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Saponins; Triterpenes | 2017 |
Astragaloside IV Supplementation Promotes A Neuroprotective Effect in Experimental Models of Neurological Disorders: A Systematic Review.
Topics: Alzheimer Disease; Animals; Brain Ischemia; Encephalomyelitis; Humans; Nervous System Diseases; Neuroprotective Agents; Parkinson Disease; Saponins; Triterpenes | 2019 |
Astragaloside IV derived from Astragalus membranaceus: A research review on the pharmacological effects.
Topics: Animals; Antineoplastic Agents; Apoptosis; Astragalus propinquus; Humans; Neuroprotection; Research; Saponins; Triterpenes | 2020 |
An updated role of astragaloside IV in heart failure.
Topics: Cardiovascular Agents; Drugs, Chinese Herbal; Heart Failure; Humans; Saponins; Triterpenes | 2020 |
Renal protective effects of astragaloside IV, in diabetes mellitus kidney damage animal models: A systematic review, meta-analysis.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Humans; Saponins; Triterpenes | 2020 |
Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases.
Topics: Astragalus propinquus; Cardiovascular Diseases; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Molecular Conformation; Saponins; Triterpenes | 2020 |
Molecular mechanisms of astragaloside‑IV in cancer therapy (Review).
Topics: Apoptosis; Humans; MAP Kinase Signaling System; Neoplasm Proteins; Neoplasms; Saponins; Triterpenes; Wnt Signaling Pathway | 2021 |
Evaluation of astragaloside IV in hepatic fibrosis: A meta-analysis.
Topics: Animals; Cell Line; Disease Models, Animal; Drugs, Chinese Herbal; Liver; Liver Cirrhosis; Male; Rats; Saponins; Triterpenes | 2021 |
Molecular Mechanism of Astragaloside IV in Improving Endothelial Dysfunction of Cardiovascular Diseases Mediated by Oxidative Stress.
Topics: Animals; Cardiovascular Diseases; Endothelium, Vascular; Humans; Oxidative Stress; Saponins; Triterpenes | 2021 |
Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2/SLC7A11/GPX4 axis to inhibit PM2.5-mediated lung injury in mice.
Topics: Animals; Glutathione; Interleukin-1beta; Interleukin-6; Iron; Lipids; Lung Injury; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Particulate Matter; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes; Tumor Necrosis Factor-alpha | 2022 |
Research progress of astragaloside IV in the treatment of atopic diseases.
Topics: Astragalus propinquus; Humans; Hypersensitivity; Quality of Life; Saponins; Triterpenes | 2022 |
Research progress on the antitumor effects of astragaloside IV.
Topics: Antineoplastic Agents; Astragalus propinquus; Epithelial-Mesenchymal Transition; Saponins; Triterpenes | 2023 |
Astragaloside IV: A promising natural neuroprotective agent for neurological disorders.
Topics: Astragalus Plant; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Nervous System Diseases; Neuroprotection; Neuroprotective Agents; Saponins; Triterpenes | 2023 |
The Molecular Basis of the Anti-Inflammatory Property of Astragaloside IV for the Treatment of Diabetes and Its Complications.
Topics: Anti-Inflammatory Agents; Antioxidants; Diabetes Mellitus; Humans; Inflammation; Saponins | 2023 |
The beneficial effects of astragaloside IV on ameliorating diabetic kidney disease.
Topics: Diabetes Mellitus; Diabetic Nephropathies; Epithelial-Mesenchymal Transition; Humans; Kidney; Saponins; Triterpenes | 2023 |
Untapping the Potential of Astragaloside IV in the Battle Against Respiratory Diseases.
Topics: Drugs, Chinese Herbal; Humans; Oxidative Stress; Respiratory Tract Diseases; Saponins; Triterpenes | 2023 |
Pharmacological Effects of Astragaloside IV: A Review.
Topics: Astragalus Plant; Cell Proliferation; Saponins; Triterpenes | 2023 |
The potential molecular pathways of Astragaloside-IV in colorectal cancer: A systematic review.
Topics: Apoptosis; Colorectal Neoplasms; Humans; Multicenter Studies as Topic; Saponins; Triterpenes | 2023 |
Recent pharmacological advances in the treatment of cardiovascular events with Astragaloside IV.
Topics: Cardiovascular Diseases; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Saponins; Triterpenes | 2023 |
5 trial(s) available for astragaloside a and beta-escin
| Article | Year |
|---|---|
[Nuclear cardiology study on effective ingredients of Astragalus membranaceus in treating heart failure].
Topics: Adolescent; Adult; Aged; Astragalus propinquus; Cardiotonic Agents; Drugs, Chinese Herbal; Female; Gated Blood-Pool Imaging; Glucosides; Heart Failure; Humans; Injections, Intravenous; Male; Middle Aged; Saponins; Single-Blind Method; Triterpenes; Ventricular Function, Left | 1995 |
Aqueous extract of Astragali Radix induces human natriuresis through enhancement of renal response to atrial natriuretic peptide.
Topics: Adult; Astragalus propinquus; Atrial Natriuretic Factor; Creatinine; Cross-Over Studies; Cyclic GMP; Electrolytes; Humans; Kidney; Male; Natriuresis; Natriuretic Agents; Plant Extracts; Plant Roots; Saponins; Triterpenes | 2008 |
Astragaloside IV attenuates Toll-like receptor 4 expression via NF-κB pathway under high glucose condition in mesenchymal stem cells.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Diabetes Mellitus, Type 1; Drugs, Chinese Herbal; Glucose; Humans; Matrix Metalloproteinase 2; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; RNA, Messenger; Saponins; Toll-Like Receptor 4; Transcription Factor RelA; Triterpenes; Tumor Necrosis Factor-alpha | 2012 |
Astragaloside IV reverses MNNG-induced precancerous lesions of gastric carcinoma in rats: Regulation on glycolysis through miRNA-34a/LDHA pathway.
Topics: Animals; Drugs, Chinese Herbal; Glycolysis; Male; Rats; Rats, Sprague-Dawley; Saponins; Stomach Neoplasms; Triterpenes | 2018 |
Pharmacokinetics-based comprehensive strategy to identify multiple effective components in Huangqi decoction against liver fibrosis.
Topics: Adolescent; Adult; Animals; Chalcone; Chromatography, Liquid; Drugs, Chinese Herbal; Flavanones; Glucosides; Glycyrrhizic Acid; Humans; Liver Cirrhosis; Male; Mass Spectrometry; Mice, Inbred C57BL; Middle Aged; Saponins; Triterpenes; Young Adult | 2021 |
571 other study(ies) available for astragaloside a and beta-escin
| Article | Year |
|---|---|
[Effects of astragalus (ASI, SK) on experimental liver injury].
Topics: Acetaminophen; Alanine Transaminase; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Galactosamine; Glucosides; Glutathione; Male; Malondialdehyde; Mice; Microsomes, Liver; Rats; Saponins; Triterpenes | 1992 |
[Quantitative determination of astragaloside A in Astragalus membranaceus].
Topics: Antihypertensive Agents; Astragalus propinquus; Fabaceae; Glucosides; Glycosides; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Phytotherapy; Plants, Medicinal; Saponins; Triterpenes | 1986 |
[A new method for qualitative determination of astragaloside].
Topics: Chromatography, Thin Layer; Drug Combinations; Drugs, Chinese Herbal; Glucosides; Hypoglycemic Agents; Saponins; Tablets; Triterpenes | 1995 |
A precolumn derivatization high-performance liquid chromatographic method with improved sensitivity and specificity for the determination of astragaloside IV in Radix Astragali.
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Glucosides; Molecular Structure; Plant Roots; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes | 2000 |
[A study on processing of the root of Astragalus membranaceus Bge. by HPLC].
Topics: Astragalus propinquus; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Glucosides; Hot Temperature; Plant Roots; Saponins; Technology, Pharmaceutical; Triterpenes | 1998 |
[Experimental studies on the quality of ostracean powder].
Topics: Amino Acids; Animals; Calcium Carbonate; Drug Combinations; Drugs, Chinese Herbal; Glucosides; Materia Medica; Ostreidae; Quality Control; Saponins; Trace Elements; Triterpenes | 1998 |
Determination of astragaloside IV in Radix astragali (Astragalus membranaceus var. monghulicus) using high-performance liquid chromatography with evaporative light-scattering detection.
Topics: Astragalus Plant; Astragalus propinquus; Chromatography, High Pressure Liquid; Glucosides; Light; Reproducibility of Results; Saponins; Scattering, Radiation; Triterpenes | 2001 |
Antinociceptive effect of astragalosides and its mechanism of action.
Topics: Analgesics, Non-Narcotic; Animals; Male; Mice; Naloxone; Nitric Oxide; Nociceptors; Pain Measurement; Saponins; Triterpenes | 2001 |
Effect of astragaloside IV on T, B lymphocyte proliferation and peritoneal macrophage function in mice.
Topics: Animals; B-Lymphocytes; Cell Division; Drugs, Chinese Herbal; Female; Fibroblasts; Interleukin-1; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Saponins; T-Lymphocytes; Triterpenes; Tumor Necrosis Factor-alpha | 2002 |
[Determination of astragaloside IV in radix Astragali by HPLC with evaporative light scattering detector].
Topics: Astragalus propinquus; Chromatography, High Pressure Liquid; Plant Roots; Plants, Medicinal; Saponins; Triterpenes | 2000 |
Effects of astragaloside IV on myocardial calcium transport and cardiac function in ischemic rats.
Topics: Animals; Biological Transport, Active; Calcium; Cardiac Output; Drugs, Chinese Herbal; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Wistar; Saponins; Triterpenes | 2002 |
[Effects of components isolated from Astragalus membranaceus Bunge on cardiac function injured by myocardial ischemia reperfusion in rats].
Topics: Animals; Astragalus propinquus; Cardiotonic Agents; Drugs, Chinese Herbal; Flavonoids; Heart Function Tests; Male; Malondialdehyde; Myocardial Reperfusion Injury; Myocardium; Plants, Medicinal; Random Allocation; Rats; Rats, Wistar; Saponins; Sodium-Potassium-Exchanging ATPase; Triterpenes | 2000 |
[Scavenging effects of Astragalus and Gynostemma pentaphyllum with its product on O2-. and .OH].
Topics: Astragalus Plant; Drugs, Chinese Herbal; Electrochemistry; Free Radical Scavengers; Ginsenosides; Gynostemma; Hydroxyl Radical; Plant Roots; Plants, Medicinal; Reactive Oxygen Species; Saponins; Triterpenes | 1999 |
Determination of serum astragaloside in rats fed with Buyanghuanwu dicoction using solidphase extraction, chemical derivatization and fluorospectrophotometry.
Topics: Animals; Drugs, Chinese Herbal; Rats; Saponins; Spectrophotometry; Triterpenes | 2003 |
Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression.
Topics: Anti-Inflammatory Agents; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Drugs, Chinese Herbal; E-Selectin; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Leukocytes; Lipopolysaccharides; NF-kappa B; Saponins; Triterpenes; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 2003 |
Astragaloside IV and polysaccharide production by hairy roots of Astragalus membranaceus in bioreactors.
Topics: Astragalus propinquus; Bioreactors; Cell Culture Techniques; Pilot Projects; Plant Roots; Polysaccharides; Saponins; Triterpenes | 2003 |
Determination of Astragaloside IV in rat plasma by liquid chromatography electrospray ionization mass spectrometry.
Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Rats; Rats, Sprague-Dawley; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2004 |
Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia.
Topics: Animals; Brain Chemistry; Brain Ischemia; Cardiotonic Agents; Catalase; Cerebral Infarction; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glutathione Peroxidase; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Reperfusion Injury; Saponins; Superoxide Dismutase; Triterpenes | 2004 |
[Effect of astrgaloside IV on the long-term consequences of renal ischemia-reperfusion injury in rat].
Topics: Animals; Down-Regulation; Drugs, Chinese Herbal; Kidney; Male; Nephrectomy; Phytotherapy; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Saponins; Transforming Growth Factor beta; Triterpenes | 2004 |
Transport and bioavailability studies of astragaloside IV, an active ingredient in Radix Astragali.
Topics: Animals; Bile Ducts; Biological Availability; Caco-2 Cells; Drugs, Chinese Herbal; Humans; Intestinal Absorption; Male; Perfusion; Permeability; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2004 |
[Studies on chromatography fingerprint of huangqi by HPLC].
Topics: Astragalus propinquus; Chromatography, High Pressure Liquid; Isoflavones; Plant Roots; Plants, Medicinal; Quality Control; Saponins; Triterpenes | 2004 |
Effect of astragalosides on intracellular calcium overload in cultured cardiac myocytes of neonatal rats.
Topics: Aldehydes; Animals; Animals, Newborn; Calcium; Calcium-Transporting ATPases; Cardiotonic Agents; Cells, Cultured; Drugs, Chinese Herbal; Enzyme Activation; Gene Expression Regulation, Enzymologic; Isoproterenol; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; RNA, Messenger; Saponins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Superoxide Dismutase; Triterpenes | 2005 |
Separation of compounds interacting with liposome membrane in combined prescription of traditional Chinese medicines with immobilized liposome chromatography.
Topics: Chromatography; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Hydrogen-Ion Concentration; Isoflavones; Liposomes; Phosphatidylcholines; Saponins; Technology, Pharmaceutical; Triterpenes | 2005 |
Quantitative determination of Astragaloside IV, a natural product with cardioprotective activity, in plasma, urine and other biological samples by HPLC coupled with tandem mass spectrometry.
Topics: Animals; Cardiotonic Agents; Chromatography, High Pressure Liquid; Dogs; Drug Stability; Drugs, Chinese Herbal; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Sensitivity and Specificity; Triterpenes | 2005 |
Quantitation of astragaloside IV in rat plasma by liquid chromatography-tandem mass spectrometry.
Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Rats; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2005 |
Gastroprotective effect of Astragaloside IV: role of prostaglandins, sulfhydryls and nitric oxide.
Topics: Animals; Anti-Ulcer Agents; Astragalus Plant; Carbenoxolone; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ethanol; Gastric Mucosa; Male; Nitric Oxide; Plant Roots; Prostaglandins; Rats; Rats, Wistar; Saponins; Stomach Ulcer; Structure-Activity Relationship; Sulfhydryl Compounds; Triterpenes | 2005 |
Sensitive and selective liquid chromatography-electrospray ionisation-mass spectrometry analysis of astragaloside-IV in rat plasma.
Topics: Animals; Chromatography, High Pressure Liquid; Indicators and Reagents; Quality Control; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Saponins; Solutions; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2006 |
The role of astragaloside in regeneration of the peripheral nerve system.
Topics: Animals; Axons; Dose-Response Relationship, Drug; Rats; Rats, Sprague-Dawley; Regeneration; Saponins; Sciatic Nerve; Triterpenes | 2006 |
[Study on new extraction technology of astragaloside IV].
Topics: Astragalus propinquus; Carbon Dioxide; Chromatography, Supercritical Fluid; Ethanol; Plant Roots; Plants, Medicinal; Pressure; Saponins; Technology, Pharmaceutical; Temperature; Time Factors; Triterpenes | 2005 |
Effects of astragaloside IV on pathogenesis of metabolic syndrome in vitro.
Topics: Adipocytes; Animals; Apoptosis; Astragalus propinquus; Calcium; Cell Differentiation; Cell Survival; Cells, Cultured; Endothelial Cells; Glucose; Insulin Resistance; Male; Metabolic Syndrome; Plant Roots; Plants, Medicinal; PPAR gamma; Rats; Rats, Sprague-Dawley; RNA, Messenger; Saponins; Triterpenes; Tumor Necrosis Factor-alpha | 2006 |
Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro.
Topics: Animals; Astragalus propinquus; Dogs; In Vitro Techniques; Male; Molecular Structure; Myocardial Ischemia; Nitric Oxide Synthase Type III; Phytotherapy; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Saponins; Superoxide Dismutase; Triterpenes | 2006 |
Astragaloside IV exerts antiviral effects against coxsackievirus B3 by upregulating interferon-gamma.
Topics: Animals; Animals, Newborn; Antiviral Agents; Cell Line, Tumor; Cells, Cultured; Coxsackievirus Infections; Enterovirus B, Human; Injections, Intraperitoneal; Interferon-gamma; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Myocarditis; Myocytes, Cardiac; RNA, Messenger; Saponins; Triterpenes; Up-Regulation; Virus Replication | 2006 |
Preclinical pharmacokinetics and tissue distribution of a natural cardioprotective agent astragaloside IV in rats and dogs.
Topics: Animals; Blood Proteins; Cardiotonic Agents; Chromatography, High Pressure Liquid; Dogs; Female; Male; Mass Spectrometry; Protein Binding; Rats; Saponins; Tissue Distribution; Triterpenes | 2006 |
Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties.
Topics: Angelica sinensis; Astragalus propinquus; Cell Division; Cell Line, Tumor; Coumaric Acids; Drugs, Chinese Herbal; Humans; Isoflavones; Osteoblasts; Plant Roots; Platelet Aggregation Inhibitors; Promoter Regions, Genetic; Receptors, Estrogen; Saponins; Triterpenes | 2006 |
Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells.
Topics: Actins; Algorithms; Apoptosis; Blood-Air Barrier; Blotting, Western; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Electric Impedance; Endothelial Cells; Glucose; Humans; Phalloidine; Protein Kinase C; Saponins; Triterpenes; Umbilical Veins | 2006 |
Astragaloside IV dilates aortic vessels from normal and spontaneously hypertensive rats through endothelium-dependent and endothelium-independent ways.
Topics: Animals; Aorta, Thoracic; Cardiotonic Agents; Endothelium, Vascular; In Vitro Techniques; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Saponins; Signal Transduction; Triterpenes; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2006 |
Inhibitory effects of astragaloside IV on diabetic peripheral neuropathy in rats.
Topics: Adenosine Triphosphatases; Aldehyde Reductase; Animals; Behavior, Animal; Blood Glucose; Body Weight; Cation Transport Proteins; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Erythrocytes; Glutathione Peroxidase; Glycated Hemoglobin; Glycation End Products, Advanced; Insulin; Models, Biological; Motor Activity; Pain Measurement; Rats; Rats, Sprague-Dawley; Saponins; Sural Nerve; Triterpenes | 2006 |
Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus.
Topics: Amyloid beta-Peptides; Animals; Astragalus Plant; Axons; Cell Survival; Cells, Cultured; Cognition Disorders; Hippocampus; Injections, Intraventricular; Male; Maze Learning; Memory Disorders; Mice; Nerve Growth Factor; Neurofilament Proteins; Neurons; Peptide Fragments; Plant Extracts; Plant Roots; Retention, Psychology; Saponins; Synapses; Synaptophysin; Temporal Lobe; Triterpenes | 2006 |
Simultaneous analysis of seven astragalosides in Radix Astragali and related preparations by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry.
Topics: Astragalus Plant; Astragalus propinquus; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Molecular Structure; Reference Standards; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2006 |
[Determination of three constituents in Radix Astragali by HPLC-MS].
Topics: Astragalus Plant; Astragalus propinquus; China; Chromatography, High Pressure Liquid; Ecosystem; Glucosides; Isoflavones; Plant Roots; Plants, Medicinal; Reproducibility of Results; Saponins; Seasons; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2006 |
[Study on fingerprints of astragalosides injection by HPLC-ELSD].
Topics: Astragalus propinquus; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Injections; Light; Plants, Medicinal; Quality Control; Saponins; Scattering, Radiation; Triterpenes | 2006 |
[Anti-apoptosis effect of astragaloside on adriamycin induced rat's cardiotoxicity].
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cardiomyopathies; Doxorubicin; Female; Immunohistochemistry; In Situ Nick-End Labeling; Male; Myocytes, Cardiac; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saponins; Triterpenes | 2006 |
[The effect of icariin and astragalosid I on the proliferation and differentiation of bone marrow stromal cells].
Topics: Alkaline Phosphatase; Animals; Astragalus propinquus; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dogs; Drugs, Chinese Herbal; Flavonoids; Osteogenesis; Plants, Medicinal; Saponins; Stromal Cells; Time Factors; Triterpenes | 2006 |
Effect of astragaloside on cardiomyocyte apoptosis in murine coxsackievirus B3 myocarditis.
Topics: Animals; Apoptosis; Coxsackievirus Infections; Enterovirus; Gene Expression; Mice; Mice, Inbred BALB C; Myocarditis; Myocytes, Cardiac; Saponins; Triterpenes | 2007 |
Modification of alterations in cardiac function and sarcoplasmic reticulum by astragaloside IV in myocardial injury in vivo.
Topics: Animals; Blood Pressure; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Creatine Kinase; Drugs, Chinese Herbal; Heart; Heart Injuries; Heart Rate; L-Lactate Dehydrogenase; Male; Malondialdehyde; Myocardium; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Saponins; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Superoxide Dismutase; Triterpenes | 2007 |
Development of microwave assisted extraction for the simultaneous determination of isoflavonoids and saponins in radix astragali by high performance liquid chromatography.
Topics: Astragalus propinquus; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Isoflavones; Microwaves; Molecular Structure; Plant Roots; Saponins; Solid Phase Extraction; Triterpenes | 2007 |
[Fundamentally study on mathematical kinetic model of component extraction from FTCM].
Topics: Algorithms; Drug Combinations; Drugs, Chinese Herbal; Kinetics; Mathematics; Models, Biological; Plants, Medicinal; Saponins; Triterpenes | 2007 |
Determination of seventeen main flavonoids and saponins in the medicinal plant Huang-qi (Radix astragali) by HPLC-DAD-ELSD.
Topics: Astragalus Plant; Astragalus propinquus; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Light; Saponins; Scattering, Radiation; Triterpenes | 2007 |
Simultaneous characterization of isoflavonoids and astragalosides in two Astragalus species by high-performance liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry.
Topics: Astragalus Plant; Atmospheric Pressure; Chromatography, High Pressure Liquid; Isoflavones; Molecular Structure; Plant Extracts; Saponins; Tandem Mass Spectrometry; Triterpenes | 2007 |
[Effect of astragaloside on myocardial fibrosis in chronic myocarditis].
Topics: Animals; Blotting, Western; Chronic Disease; Coxsackievirus Infections; Drugs, Chinese Herbal; Endomyocardial Fibrosis; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase 14; Mice; Mice, Inbred BALB C; Myocarditis; Random Allocation; Saponins; Transforming Growth Factor beta; Triterpenes | 2007 |
[Protective effects of Astragaloside and Quercetin on rat myocardial cells after hypoxia].
Topics: Animals; Cell Hypoxia; Myocytes, Cardiac; Quercetin; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2007 |
[Investigation on one-pot extraction of active ingredient group from Yupingfeng powder by HPLC].
Topics: Apiaceae; Astragalus propinquus; Atractylodes; Chemical Fractionation; Chromatography, High Pressure Liquid; Drug Combinations; Drugs, Chinese Herbal; Ethanol; Monosaccharides; Plants, Medicinal; Powders; Saponins; Temperature; Triterpenes; Water; Xanthenes | 2007 |
[Astragalus polysaccharides and astragalosides regulate cytokine secretion in LX-2 cell line].
Topics: Astragalus propinquus; Cell Line; Cytokines; Hepatic Stellate Cells; Humans; Interleukin-10; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Plant Roots; Polysaccharides; RNA, Messenger; Saponins; Triterpenes; Up-Regulation | 2007 |
Astragaloside IV inhibits spontaneous synaptic transmission and synchronized Ca2+ oscillations on hippocampal neurons.
Topics: Animals; Calcium Signaling; Cells, Cultured; Electrophysiology; Hippocampus; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Saponins; Synaptic Transmission; Triterpenes | 2008 |
[Effects of AST and ASI on metabolism of free radical in senescent rats treated by HC].
Topics: Aging; Animals; Astragalus propinquus; Catalase; Cell Proliferation; Cerebral Cortex; Female; Free Radicals; Glutathione; Glutathione Disulfide; Hydrocortisone; Interleukin-2; Liver; Male; Malondialdehyde; Plants, Medicinal; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins; Spleen; Superoxide Dismutase; Triterpenes | 2007 |
Simultaneous determination of calycosin-7-O-beta-D-glucoside, ononin, astragaloside IV, astragaloside I and ferulic acid in rat plasma after oral administration of Danggui Buxue Tang extract for their pharmacokinetic studies by liquid chromatography-mass
Topics: Administration, Oral; Animals; Calibration; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Glucosides; Isoflavones; Plant Extracts; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2008 |
Astragaloside IV improved intracellular calcium handling in hypoxia-reoxygenated cardiomyocytes via the sarcoplasmic reticulum Ca-ATPase.
Topics: Animals; Animals, Newborn; Astragalus propinquus; Calcium; Cell Hypoxia; Cells, Cultured; Dose-Response Relationship, Drug; Fluorescent Dyes; Fura-2; Gene Expression Regulation; Myocytes, Cardiac; Oxygen; Rats; RNA, Messenger; Saponins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Triterpenes | 2008 |
[Amic solution hydrolysis for improving content of astragaloside IV in extract of Radix Astragali].
Topics: Astragalus propinquus; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Hydrolysis; Saponins; Solutions; Triterpenes | 2008 |
[Determination of the total content of astragaloside IV in Radix Astragali].
Topics: Astragalus propinquus; Chromatography, High Pressure Liquid; Pharmacognosy; Plant Roots; Plants, Medicinal; Quality Control; Reproducibility of Results; Saponins; Temperature; Triterpenes | 2008 |
Astragaloside IV inhibits proliferation and promotes apoptosis in rat vascular smooth muscle cells under high glucose concentration in vitro.
Topics: Animals; Aorta; Apoptosis; Cell Proliferation; Cells, Cultured; Drugs, Chinese Herbal; Glucose; Male; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2008 |
Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthma.
Topics: Actins; Allergens; Animals; Anti-Asthmatic Agents; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid; Chronic Disease; Collagen; Cytokines; Female; Fibrosis; Hydroxyproline; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Saponins; Th2 Cells; Transforming Growth Factor beta1; Triterpenes | 2008 |
Astragaloside IV improves high glucose-induced podocyte adhesion dysfunction via alpha3beta1 integrin upregulation and integrin-linked kinase inhibition.
Topics: Animals; Cell Adhesion; Cell Line, Transformed; Cells, Cultured; Glucose; Integrin alpha3beta1; Mice; Podocytes; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Saponins; Triterpenes; Up-Regulation | 2008 |
[Study on absorption kinetics of astragaloside IV in rats intestines].
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, High Pressure Liquid; Intestinal Absorption; Intestinal Mucosa; Kinetics; Male; Perfusion; Rats; Rats, Wistar; Saponins; Triterpenes; Verapamil | 2008 |
Astragaloside IV attenuates lipolysis and improves insulin resistance induced by TNFalpha in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Analysis of Variance; Animals; Carrier Proteins; Fatty Acid Synthases; Fatty Acids, Nonesterified; Gene Expression Regulation; Insulin Resistance; Lipolysis; Medicine, Chinese Traditional; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Perilipin-1; Phosphoproteins; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Saponins; Triterpenes; Tumor Necrosis Factor-alpha | 2008 |
Astragaloside IV attenuates hypoxia-induced cardiomyocyte damage in rats by upregulating superoxide dismutase-1 levels.
Topics: Animals; Animals, Newborn; Cell Hypoxia; Cell Survival; Cells, Cultured; Cytoprotection; Drug Evaluation, Preclinical; Gene Expression Regulation, Enzymologic; Models, Biological; Myocytes, Cardiac; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Superoxide Dismutase; Superoxide Dismutase-1; Triterpenes; Up-Regulation | 2009 |
Anti-hepatitis B virus activities of astragaloside IV isolated from radix Astragali.
Topics: Animals; Astragalus Plant; Carcinoma; Cell Line, Tumor; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ducks; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B Virus, Duck; Humans; Saponins; Transfection; Triterpenes | 2009 |
Effect of astragaloside IV on the embryo-fetal development of Sprague-Dawley rats and New Zealand White rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Cardiotonic Agents; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Embryonic Development; Female; Fetal Development; Gestational Age; Male; Medicine, Chinese Traditional; Pregnancy; Rabbits; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2009 |
Astragaloside IV attenuates cerebral ischemia-reperfusion-induced increase in permeability of the blood-brain barrier in rats.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Male; Membrane Proteins; Microscopy, Electron; Occludin; Permeability; Phosphoproteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins; Tight Junctions; Triterpenes; Zonula Occludens-1 Protein | 2009 |
[Study on the determination method of the astragaloside IV in health food].
Topics: Chromatography, High Pressure Liquid; Dietary Supplements; Food, Organic; Saponins; Solid Phase Extraction; Triterpenes | 2009 |
Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture.
Topics: Animals; Animals, Newborn; Cell Death; Cell Differentiation; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Nerve Degeneration; Neurites; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type I; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Saponins; Substantia Nigra; Sympatholytics; Triterpenes; Tyrosine 3-Monooxygenase | 2009 |
Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells.
Topics: Alanine Transaminase; Animals; Astragalus Plant; Body Weight; Collagen; Collagen Type III; Hepatic Stellate Cells; Humans; Hyaluronic Acid; Hydroxyproline; Liver; Liver Cirrhosis; Male; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Saponins; Transforming Growth Factor beta1; Triterpenes | 2009 |
Effect of astragaloside IV on hepatic glucose-regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin.
Topics: Animals; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Glucose-6-Phosphatase; Glycogen Phosphorylase; Hypoglycemic Agents; Insulin; Liver; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Saponins; Streptozocin; Triglycerides; Triterpenes | 2010 |
Astragalosides isolated from the root of astragalus radix inhibit the formation of advanced glycation end products.
Topics: Arginine; Astragalus Plant; Diabetes Complications; Glycation End Products, Advanced; Lysine; Plant Extracts; Plant Roots; Saponins; Triterpenes | 2009 |
Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis.
Topics: 4-Butyrolactone; Angelica sinensis; Astragalus propinquus; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Drug Antagonism; Drugs, Chinese Herbal; Humans; Isoflavones; Medicine, Chinese Traditional; Polysaccharides; Saponins; Triterpenes | 2010 |
[Effects of Astragalus injection and its ingredients on proliferation and Akt phosphorylation of breast cancer cell lines].
Topics: Apoptosis; Astragalus Plant; Breast Neoplasms; Cell Proliferation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Isoflavones; Oncogene Protein v-akt; Phosphorylation; Phytoestrogens; Saponins; Triterpenes | 2009 |
Effects of cycloartane saponins from hairy roots of Astragalus membranaceus Bge., on human tumor cell targets.
Topics: Antineoplastic Agents, Phytogenic; Astragalus propinquus; Bioreactors; Cell Culture Techniques; Cell Line, Tumor; Humans; Neoplasms; Plant Extracts; Plant Roots; Saponins; Triterpenes | 2010 |
Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; DNA Primers; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Mass Spectrometry; Peptides; Plant Preparations; Proteomics; Reverse Transcriptase Polymerase Chain Reaction; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Triterpenes | 2010 |
Cigarette smoke enhances {beta}-defensin 2 expression in rat airways via nuclear factor-{kappa}B activation.
Topics: Animals; beta-Defensins; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation; Glutathione; Male; NF-kappa B; Nitric Oxide; Rats; Rats, Wistar; Saponins; Smoking; Trachea; Triterpenes | 2010 |
[Inhibitory effect on activated renin-angiotensin system by astragaloside IV in rats with pressure-overload induced cardiac hypertrophy].
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Enzyme-Linked Immunosorbent Assay; Hypertrophy, Left Ventricular; Male; Peptidyl-Dipeptidase A; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Saponins; Triterpenes | 2009 |
Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation.
Topics: Acetylcholine; Animals; Antioxidants; Aorta; Astragalus propinquus; Cell Culture Techniques; Endothelial Cells; Endothelium, Vascular; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase; Phytotherapy; Plant Extracts; Rats; Reactive Oxygen Species; Saponins; Signal Transduction; Superoxide Dismutase; Triterpenes; Umbilical Veins; Vascular Diseases; Vasodilation | 2010 |
[Stem cell factor secretion by bone mesenchymal stem cells stimulated with astragaloside IV].
Topics: Animals; Bone Marrow Cells; Cell Proliferation; Mesenchymal Stem Cells; Rats; Rats, Wistar; RNA, Messenger; Saponins; Stem Cell Factor; Triterpenes | 2010 |
Protective effect of astragaloside on focal cerebral ischemia/reperfusion injury in rats.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Drugs, Chinese Herbal; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Lactates; Male; Malondialdehyde; Nerve Growth Factor; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Receptor, trkA; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Saponins; Superoxide Dismutase; Time Factors; Triterpenes; Water | 2010 |
[Study on preventative and curative effects of astragaloside (AST) on mice memory impairment and expression of amyloid precursor protein and beta secretase mRNA induced by dexamethasone].
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Dexamethasone; Male; Memory Disorders; Mice; RNA, Messenger; Saponins; Triterpenes | 2010 |
Preparative enrichment and separation of astragalosides from Radix Astragali extracts using macroporous resins.
Topics: Adsorption; Astragalus Plant; Chromatography; Plant Extracts; Porosity; Resins, Synthetic; Saponins; Triterpenes | 2010 |
[Transformation of astragaloside IV in bidirectional solid fermenting of Astragalus membranaceus].
Topics: Antioxidants; Astragalus propinquus; Chromatography, High Pressure Liquid; Fermentation; Ganoderma; Molecular Structure; Plant Roots; Plants, Medicinal; Sapogenins; Saponins; Triterpenes | 2010 |
[Morphological investigation of the protective effect of astragaloside preconditioning against ischemia-reperfusion lung injury in rats].
Topics: Animals; Female; Ischemic Preconditioning; Lung; Male; Phytotherapy; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins; Triterpenes | 2010 |
Effects of astragaloside IV on IFN-gamma level and prolonged airway dysfunction in a murine model of chronic asthma.
Topics: Animals; Asthma; Astragalus Plant; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Chronic Disease; Collagen; Disease Models, Animal; Drugs, Chinese Herbal; Female; Immune System; Inflammation; Interferon-gamma; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Phytotherapy; Plant Roots; Respiratory System; Saponins; Triterpenes | 2011 |
Comparative investigations on the protective effects of rhodioside, ciwujianoside-B and astragaloside IV on radiation injuries of the hematopoietic system in mice.
Topics: Animals; Astragalus propinquus; bcl-2-Associated X Protein; Bone Marrow Cells; Cell Cycle; DNA Damage; Eleutherococcus; Gamma Rays; Glycosides; Hematopoietic System; Leukocytes; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; Radiation Injuries, Experimental; Radiation-Protective Agents; Random Allocation; Rhodiola; Saponins; Stem Cells; Triterpenes; Whole-Body Irradiation | 2011 |
The known immunologically active components of Astragalus account for only a small proportion of the immunological adjuvant activity when combined with conjugate vaccines.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Neoplasm; Antibody Formation; Astragalus propinquus; Cancer Vaccines; Enzyme-Linked Immunosorbent Assay; Female; Flavonoids; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Plant Extracts; Saponins; Triterpenes; Vaccines, Conjugate | 2011 |
Astragaloside IV synergizes with ferulic acid to inhibit renal tubulointerstitial fibrosis in rats with obstructive nephropathy.
Topics: Animals; Cell Transdifferentiation; Cells, Cultured; Coumaric Acids; Drug Synergism; Fibroblasts; Fibrosis; Humans; Kidney; Kidney Tubules, Proximal; Male; Nephritis, Interstitial; Nitric Oxide; Phosphorylation; Rats; Rats, Wistar; Saponins; Triterpenes; Ureteral Obstruction | 2011 |
[Protective effect of astragalosides on anoxia/reoxygenation injury of hippocampal neuron].
Topics: Animals; Calcium; Cell Hypoxia; Female; Fetus; Hippocampus; Malondialdehyde; Neurons; Neuroprotective Agents; Nitric Oxide; Pregnancy; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins; Superoxide Dismutase; Triterpenes | 2010 |
Astragaloside IV attenuates myocardial fibrosis by inhibiting TGF-β1 signaling in coxsackievirus B3-induced cardiomyopathy.
Topics: Animals; Cardiomyopathy, Dilated; Collagen; Down-Regulation; Enterovirus B, Human; Fibrosis; Male; Mice; Mice, Inbred BALB C; Myocarditis; Myocardium; Saponins; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Triterpenes | 2011 |
The osteogenetic effect of astragaloside IV with centrifugating pressure on the OCT-1 cells.
Topics: Alkaline Phosphatase; Animals; Cell Line; Centrifugation; Collagen Type I; Coloring Agents; Core Binding Factor Alpha 1 Subunit; Fluorescent Antibody Technique; Osteocalcin; Osteogenesis; Posture; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA; Saponins; Tetrazolium Salts; Thiazoles; Triterpenes | 2011 |
Protective effects of astragaloside against ultraviolet A-induced photoaging in human fibroblasts.
Topics: Cells, Cultured; Fibroblasts; Humans; Saponins; Skin Aging; Triterpenes; Ultraviolet Rays | 2011 |
Astragaloside IV inhibits adenovirus replication and apoptosis in A549 cells in vitro.
Topics: Adenoviridae; Adenoviridae Infections; Antiviral Agents; Apoptosis; Astragalus propinquus; bcl-2-Associated X Protein; Caspase 3; Cell Line; Humans; Inhibitory Concentration 50; Phytotherapy; Plant Extracts; Saponins; Triterpenes; Virus Replication | 2011 |
Astragaloside IV attenuates impulse noise-induced trauma in guinea pig.
Topics: Administration, Oral; Animals; Auditory Threshold; Disease Models, Animal; Drugs, Chinese Herbal; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Hearing Loss, Noise-Induced; Nitric Oxide Synthase Type II; Reactive Oxygen Species; Saponins; Treatment Outcome; Triterpenes | 2011 |
Astragaloside IV improves metabolic syndrome and endothelium dysfunction in fructose-fed rats.
Topics: Animals; Blood Pressure; Body Weight; Cyclic GMP; Endothelium, Vascular; Fructose; Glucose Tolerance Test; Male; Malondialdehyde; Metabolic Syndrome; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes; Vasodilation | 2011 |
Astragaloside IV stimulates angiogenesis and increases hypoxia-inducible factor-1α accumulation via phosphatidylinositol 3-kinase/Akt pathway.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chick Embryo; Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; Triterpenes | 2011 |
[Regulation of Vitreoscilla hemoglobin on biosynthesis of astragaloside IV].
Topics: Astragalus propinquus; Bacterial Proteins; Plant Roots; Plants, Genetically Modified; Plants, Medicinal; Saponins; Triterpenes; Truncated Hemoglobins; Vitreoscilla | 2011 |
Chuanxiongzine-astragaloside IV decreases IL-1β and Caspase-3 gene expressions in rat brain damaged by cerebral ischemia/reperfusion: a study of real-time quantitative PCR assay.
Topics: Animals; Brain; Brain Ischemia; Caspase 3; Interleukin-1beta; Male; Neuroprotective Agents; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reperfusion Injury; RNA, Messenger; Saponins; Triterpenes | 2011 |
Astragaloside IV protects against ischemia reperfusion in a murine model of orthotopic liver transplantation.
Topics: Animals; Base Sequence; Blotting, Western; DNA Primers; Immunohistochemistry; Liver Transplantation; Male; Mice; Microscopy, Confocal; NF-kappa B; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Reperfusion Injury; Saponins; Survival Rate; Triterpenes; Tumor Necrosis Factor-alpha | 2011 |
[Simultaneous determination of five glycosides in Aidi injection by RP-HPLC-ELSD].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ginsenosides; Glucosides; Glycosides; Injections; Phenylpropionates; Saponins; Triterpenes | 2011 |
Effect comparison of different formulation of Dang-Gui-Bu-Xu-Tang on myelosuppression mouse.
Topics: Animals; Bone Marrow Cells; Cell Cycle; Cells, Cultured; Coumaric Acids; Drugs, Chinese Herbal; Erythropoietin; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Immunocompromised Host; Leukocyte Count; Leukocytes; Male; Mice; Mice, Inbred BALB C; Saponins; Stromal Cells; Triterpenes; Whole-Body Irradiation | 2011 |
[Effect of astragaloside against the oxidative damage on endothelial cells].
Topics: Cells, Cultured; Endothelial Cells; Humans; Leukocytes, Mononuclear; Lipoproteins, LDL; Malondialdehyde; Oxidation-Reduction; Oxidative Stress; Saponins; Stem Cells; Triterpenes | 2011 |
Ultrasonic-assisted liquid-liquid extraction and HILIC-ELSD analysis of ginsenoside Rb(1), astragaloside IV and dulcitol in sugar-free "Fufangfufangteng Heji".
Topics: Calibration; Cardiotonic Agents; Chromatography, Liquid; Drug Combinations; Galactitol; Ginsenosides; Light; Liquid-Liquid Extraction; Plant Preparations; Reproducibility of Results; Saponins; Scattering, Radiation; Sound; Triterpenes | 2011 |
[Effects of astragaloside on IGF-1 and associated protein expression in mice with acute viral myocarditis].
Topics: Acute Disease; Animals; Coxsackievirus Infections; Drugs, Chinese Herbal; Enterovirus B, Human; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred BALB C; Myocarditis; Myocardium; Receptor, IGF Type 1; RNA, Messenger; Saponins; Triterpenes | 2011 |
Protective effect of astragaloside IV against matrix metalloproteinase-1 expression in ultraviolet-irradiated human dermal fibroblasts.
Topics: Blotting, Western; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Inhibitors; Fibroblasts; Genes, Reporter; Humans; Luciferases; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Molecular Structure; NF-kappa B; Radiation-Protective Agents; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Saponins; Transfection; Triterpenes; Ultraviolet Rays | 2011 |
[Determination of astragaloside IV of eight area in Astragali Radix is by HPLC-ELSD internal standard method].
Topics: Astragalus Plant; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Linear Models; Reference Standards; Saponins; Triterpenes | 2011 |
Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types.
Topics: Astragalus Plant; Brain; Breast; Cell Line; Dose-Response Relationship, Drug; Endothelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Lung; Phosphorylation; Plant Extracts; Sapogenins; Saponins; src-Family Kinases; Telomerase; Triterpenes | 2012 |
Astragaloside IV attenuates complement membranous attack complex induced podocyte injury through the MAPK pathway.
Topics: Actin Cytoskeleton; Animals; Astragalus propinquus; Cell Line; Complement Membrane Attack Complex; Cytoprotection; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glomerulonephritis, Membranous; Immunohistochemistry; Kidney Glomerulus; L-Lactate Dehydrogenase; MAP Kinase Signaling System; Mice; Phosphorylation; Podocytes; Protective Agents; Proteinuria; Saponins; Time Factors; Triterpenes | 2012 |
[Effect of ERK1/2 signaling pathway on astragaloside IV protects H9c2 cells against H2O2-induced oxidative injury].
Topics: Animals; Antioxidants; Cell Line; Hydrogen Peroxide; MAP Kinase Signaling System; Myoblasts, Cardiac; Oxidative Stress; Protective Agents; Rats; Saponins; Triterpenes | 2011 |
The healing and anti-scar effects of astragaloside IV on the wound repair in vitro and in vivo.
Topics: Animals; Astragalus Plant; Cell Movement; Cicatrix; Collagen; Dose-Response Relationship, Drug; Female; Fibroblasts; Keratinocytes; Neovascularization, Physiologic; Phytotherapy; Plant Extracts; Plant Roots; Rats; Rats, Sprague-Dawley; Regeneration; Saponins; Skin; Transforming Growth Factor beta1; Triterpenes; Wound Healing | 2012 |
[Immunoregulatory mechanisms of an optimal Chinese herbal monomer compound in mice with allergic rhinitis].
Topics: Animals; Cell Proliferation; Cells, Cultured; Drug Compounding; Drugs, Chinese Herbal; Flavonoids; Immunomodulation; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Saponins; Spleen; Triterpenes | 2011 |
Pro-angiogenic activity of astragaloside IV in HUVECs in vitro and zebrafish in vivo.
Topics: Angiogenesis Inducing Agents; Animals; Astragalus Plant; Astragalus propinquus; Cell Movement; Cell Proliferation; Cells, Cultured; Drugs, Chinese Herbal; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Neovascularization, Physiologic; Phosphatidylinositols; Proto-Oncogene Proteins c-akt; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Saponins; Triterpenes; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Zebrafish | 2012 |
Synergistic protective effect of astragaloside IV-tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia.
Topics: Animals; Astragalus Plant; Cardiovascular Agents; Caspase 3; Disease Models, Animal; Drug Synergism; Glucose; Hippocampus; Ischemic Attack, Transient; Male; Malondialdehyde; Neuroprotective Agents; Nimodipine; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Positron-Emission Tomography; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Saponins; Superoxide Dismutase; Triterpenes | 2012 |
Determination of astragalin and astragaloside content in Radix Astragali using high-performance liquid chromatography coupled with pulsed amperometric detection.
Topics: Astragalus Plant; Astragalus propinquus; Chromatography, High Pressure Liquid; Drug Stability; Drugs, Chinese Herbal; Kaempferols; Limit of Detection; Linear Models; Plant Roots; Reproducibility of Results; Saponins; Triterpenes | 2012 |
Astragaloside IV inhibits apoptotic cell death in the guinea pig cochlea exposed to impulse noise.
Topics: Aldehydes; Animals; Apoptosis; Caspase 3; Cell Death; Cochlea; Disease Models, Animal; Drugs, Chinese Herbal; Evoked Potentials, Auditory, Brain Stem; Follow-Up Studies; Guinea Pigs; Hearing Loss, Noise-Induced; Immunohistochemistry; Noise; Reactive Oxygen Species; Saponins; Treatment Outcome; Triterpenes | 2012 |
Astragaloside IV prevents MPP⁺-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Survival; Dopaminergic Neurons; Gene Expression Regulation; Humans; Neuroblastoma; Parkinson Disease; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Saponins; Triterpenes | 2012 |
[Effects of astragaloside IV on the expressions of transforming growth factor-β1 and thymic stromal lymphopoietin in a murine model of asthma].
Topics: Animals; Asthma; Cytokines; Drugs, Chinese Herbal; Female; Interleukin-13; Interleukin-4; Mice; Mice, Inbred BALB C; Saponins; Thymic Stromal Lymphopoietin; Transforming Growth Factor beta1; Triterpenes | 2011 |
Astragaloside IV protects against focal cerebral ischemia/reperfusion injury correlating to suppression of neutrophils adhesion-related molecules.
Topics: Animals; Blotting, Western; Brain Ischemia; Cell Adhesion; Cell Adhesion Molecules; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immunohistochemistry; Interleukin-1beta; Male; Neutrophils; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins; Triterpenes; Tumor Necrosis Factor-alpha | 2012 |
Astragaloside IV regulates expression of ATP-sensitive potassium channel subunits after ischemia-reperfusion in rat ventricular cardiomyocytes.
Topics: Animals; Astragalus Plant; Cells, Cultured; Drugs, Chinese Herbal; Gene Expression; Heart Ventricles; Humans; KATP Channels; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Rats; Rats, Wistar; Saponins; Triterpenes | 2011 |
Effects of astragaloside IV on eosinophil activation induced by house dust mite allergen.
Topics: Allergens; Anti-Inflammatory Agents; Antigens, Dermatophagoides; Arthropod Proteins; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Cytokines; Drugs, Chinese Herbal; Eosinophils; Humans; Intercellular Adhesion Molecule-1; Receptors, CCR3; Saponins; Time Factors; Transendothelial and Transepithelial Migration; Triterpenes | 2012 |
Pharmacokinetic evidence on the contribution of intestinal bacterial conversion to beneficial effects of astragaloside IV, a marker compound of astragali radix, in traditional oral use of the herb.
Topics: Administration, Oral; Animals; Area Under Curve; Bacteria; Biotransformation; Drugs, Chinese Herbal; Feces; Intestinal Mucosa; Intestines; Male; Rats; Rats, Sprague-Dawley; Sapogenins; Saponins; Triterpenes | 2012 |
Topical astragaloside IV-releasing hydrogel improves healing of skin wounds in vivo.
Topics: Administration, Topical; Alginates; Animals; Female; Gelatin; Glucuronic Acid; Hexuronic Acids; Hydrogels; Rats; Rats, Sprague-Dawley; Saponins; Skin; Tensile Strength; Transforming Growth Factor beta; Triterpenes; Wound Healing | 2012 |
[Inhibitory effects of astragaloside IV on cytochrome P450 enzyme of rat liver microsomes].
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Enzyme Inhibitors; Kinetics; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2012 |
Astragaloside IV, a novel antioxidant, prevents glucose-induced podocyte apoptosis in vitro and in vivo.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Cell Line; Glucose; Male; Mice; Oxidative Stress; Podocytes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Triterpenes | 2012 |
Astragaloside IV alleviates hypoxia/reoxygenation-induced neonatal rat cardiomyocyte injury via the protein kinase a pathway.
Topics: Animals; Animals, Newborn; Cardiotonic Agents; Cell Hypoxia; Cells, Cultured; Creatine Kinase, MB Form; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Myocytes, Cardiac; Protein Subunits; Rats; Reperfusion Injury; RNA, Messenger; Saponins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Triterpenes | 2012 |
Tanshinone IIA and astragaloside IV promote the migration of mesenchymal stem cells by up-regulation of CXCR4.
Topics: Abietanes; Animals; Blotting, Western; Cell Movement; Flow Cytometry; Fluorescent Antibody Technique; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Reverse Transcriptase Polymerase Chain Reaction; Saponins; Triterpenes | 2013 |
Chemical and biological assessment of Angelica herbal decoction: comparison of different preparations during historical applications.
Topics: 4-Butyrolactone; Angelica; Animals; Astragalus propinquus; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Coumaric Acids; Drugs, Chinese Herbal; Erythropoiesis; Female; Glucosides; Humans; Isoflavones; Medicine, Chinese Traditional; Osteogenesis; Plant Roots; Promoter Regions, Genetic; Receptors, Estrogen; Saponins; Triterpenes | 2012 |
The effect of Astragaloside IV on immune function of regulatory T cell mediated by high mobility group box 1 protein in vitro.
Topics: Animals; CD4 Antigens; Cell Proliferation; Cells, Cultured; Forkhead Transcription Factors; Gene Expression Regulation; HMGB1 Protein; Interleukin-10; Interleukin-2 Receptor alpha Subunit; Male; Mice; Molecular Structure; RNA, Messenger; Saponins; Spleen; T-Lymphocytes, Regulatory; Transforming Growth Factor beta; Triterpenes | 2012 |
Therapeutic effects of astragaloside IV on myocardial injuries: multi-target identification and network analysis.
Topics: Binding Sites; Cardiovascular Diseases; Computational Biology; Cytoprotection; Doxorubicin; Drug Approval; Humans; Molecular Docking Simulation; Molecular Targeted Therapy; Myocytes, Cardiac; Protein Conformation; Protein Interaction Mapping; Reproducibility of Results; Saponins; Signal Transduction; Triterpenes; United States; United States Food and Drug Administration | 2012 |
Astragaloside IV inhibits oxidative stress-induced mitochondrial permeability transition pore opening by inactivating GSK-3β via nitric oxide in H9c2 cardiac cells.
Topics: Animals; Cell Line; Cell Survival; Chromones; Cyclic GMP-Dependent Protein Kinases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morpholines; Nitric Oxide; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Saponins; Signal Transduction; Triterpenes | 2012 |
[Protective effects of astragaloside IV on high-glucose-induced damage of retinal ganglion cells].
Topics: Cell Survival; Cells, Cultured; Drugs, Chinese Herbal; Glucose; Humans; Mitochondria; Retinal Ganglion Cells; Saponins; Triterpenes | 2012 |
Astragaloside IV inhibited the activity of CYP1A2 in liver microsomes and influenced theophylline pharmacokinetics in rats.
Topics: Animals; Astragalus Plant; Astragalus propinquus; Biotransformation; China; Cytochrome P-450 CYP1A2; Cytochromes; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Enzyme Inhibitors; Ethnopharmacology; Half-Life; Kinetics; Male; Metabolic Clearance Rate; Microsomes, Liver; Phenacetin; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Saponins; Theophylline; Triterpenes | 2013 |
The experimental study of Astragalus membranaceus on meridian tropsim: the distribution study of astragaloside IV in rat tissues.
Topics: Animals; Astragalus propinquus; Chromatography, Liquid; Drug Stability; Drugs, Chinese Herbal; Linear Models; Lung; Male; Myocardium; Rats; Rats, Sprague-Dawley; Saponins; Spleen; Tandem Mass Spectrometry; Tissue Distribution; Triterpenes; Tropism | 2012 |
Astragaloside IV prevents acute kidney injury in two rodent models by inhibiting oxidative stress and apoptosis pathways.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Apoptosis; Caspase 3; Cell Adhesion Molecules; Cystatin C; Drugs, Chinese Herbal; Ischemia; Kidney; Kidney Function Tests; Lipocalin-2; Lipocalins; Male; Models, Animal; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Renal Artery; Reperfusion Injury; RNA, Messenger; Saponins; Triterpenes | 2013 |
Astragaloside content in the periderm, cortex, and xylem of Astragalus membranaceus root.
Topics: Astragalus propinquus; Chromatography, High Pressure Liquid; Plant Roots; Saponins; Triterpenes; Xylem | 2013 |
Astragaloside IV ameliorates renal injury in streptozotocin-induced diabetic rats through inhibiting NF-κB-mediated inflammatory genes expression.
Topics: Albuminuria; Animals; Biomarkers; Chemokine CCL2; Collagen Type IV; Diabetes Mellitus, Experimental; Gene Expression Regulation; Inflammation; Intercellular Adhesion Molecule-1; Kidney Diseases; Male; NF-kappa B; Podocytes; Rats; Rats, Sprague-Dawley; RNA, Messenger; Saponins; Triterpenes; Tumor Necrosis Factor-alpha | 2013 |
Astragaloside IV suppresses collagen production of activated hepatic stellate cells via oxidative stress-mediated p38 MAPK pathway.
Topics: Animals; Collagen; Extracellular Matrix; Hepatic Stellate Cells; Humans; Imidazoles; Lipid Peroxidation; Liver Cirrhosis; MAP Kinase Signaling System; NF-E2-Related Factor 2; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Pyridines; Rats; Reactive Oxygen Species; Saponins; Triterpenes | 2013 |
Astragaloside IV-loaded nanoparticle-enriched hydrogel induces wound healing and anti-scar activity through topical delivery.
Topics: Administration, Topical; Animals; Cells, Cultured; Cicatrix; Collagen; Drug Delivery Systems; Drugs, Chinese Herbal; Fibroblasts; Fluorescent Dyes; Humans; Hydrogels; Microscopy, Electron, Scanning; Nanoparticles; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Rhodamines; Saponins; Skin; Triterpenes; Wound Healing | 2013 |
Effects of astragaloside IV on action potentials and ionic currents in guinea-pig ventricular myocytes.
Topics: Action Potentials; Animals; Calcium Channels; Drugs, Chinese Herbal; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Myocytes, Cardiac; Potassium Channels; Saponins; Triterpenes | 2013 |
Genetic and pharmacological inhibition of Rheb1-mTORC1 signaling exerts cardioprotection against adverse cardiac remodeling in mice.
Topics: Animals; Apoptosis; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Drug Evaluation, Preclinical; Gene Deletion; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Myocardial Infarction; Myocytes, Cardiac; Neuropeptides; Ras Homolog Enriched in Brain Protein; Saponins; Signal Transduction; TOR Serine-Threonine Kinases; Triterpenes; Ventricular Remodeling | 2013 |
Synergistic promotion of blood vessel regeneration by astragaloside IV and ferulic acid from electrospun fibrous mats.
Topics: Blood Vessels; Cell Survival; Cells, Cultured; Coumaric Acids; Drug Synergism; Humans; Regeneration; Saponins; Tissue Engineering; Triterpenes | 2013 |
[Experimental studies on pharmacokinetics of three components in Buyanghuanwu injection on base of total quantum statistical moment].
Topics: Animals; Benzoates; Bridged-Ring Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Glucosides; Male; Medicine, Chinese Traditional; Models, Statistical; Monoterpenes; Pyrazines; Rats; Saponins; Triterpenes | 2013 |
Astragaloside IV attenuates glycated albumin-induced epithelial-to-mesenchymal transition by inhibiting oxidative stress in renal proximal tubular cells.
Topics: Actins; Animals; Antioxidants; Astragalus Plant; Cadherins; Cell Line; Cell Movement; Cell Survival; Epithelial-Mesenchymal Transition; Glycated Serum Albumin; Glycation End Products, Advanced; Kidney Tubules, Proximal; NADPH Oxidases; Oxidative Stress; Rats; Reactive Oxygen Species; RNA, Messenger; Saponins; Serum Albumin; Superoxide Dismutase; Triterpenes | 2014 |
[Protective effect and mechanism of astragaloside IV on oxidative stress injury of mesangial cells].
Topics: Apoptosis; Cell Cycle; Cell Line; Cell Survival; Cyclin A; Cyclin D1; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Hydrogen Peroxide; Mesangial Cells; Oxidative Stress; Reactive Oxygen Species; Saponins; Triterpenes | 2013 |
Can Hedysari Radix replace Astragali Radix in Danggui Buxue Tang, a Chinese herbal decoction for woman aliment?
Topics: Angelica sinensis; Astragalus Plant; Astragalus propinquus; Cell Line, Tumor; Drugs, Chinese Herbal; Estrogens; Female; Glucosides; Humans; Isoflavones; Medicine, Chinese Traditional; Saponins; Tandem Mass Spectrometry; Triterpenes | 2013 |
Astragaloside IV reduces cerebral edema post-ischemia/reperfusion correlating the suppression of MMP-9 and AQP4.
Topics: Animals; Aquaporin 4; Blood Vessels; Blood-Brain Barrier; Brain Edema; Male; Matrix Metalloproteinase 9; Permeability; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins; Treatment Outcome; Triterpenes; Water | 2013 |
Astragaloside IV protects heart from ischemia and reperfusion injury via energy regulation mechanisms.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Apoptosis; Male; Myocardial Reperfusion Injury; Myocardium; Proton-Translocating ATPases; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes; Troponin I | 2013 |
Pharmacokinetics and tolerance of toal astragalosides after intravenous infusion of astragalosides injection in healthy Chinese volunteers.
Topics: Adult; Angelica sinensis; Asian People; Dose-Response Relationship, Drug; Female; Healthy Volunteers; Humans; Infusions, Intravenous; Male; Saponins; Time Factors; Triterpenes; Young Adult | 2013 |
Identification of multiple ingredients for a Traditional Chinese Medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry.
Topics: 4-Butyrolactone; Benzoates; Bridged-Ring Compounds; Chromatography, High Pressure Liquid; Digoxin; Drugs, Chinese Herbal; Glucosides; Humans; Isoflavones; Limit of Detection; Medicine, Chinese Traditional; Monoterpenes; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Triterpenes | 2013 |
Comparative tissue distribution profiles of five major bio-active components in normal and blood deficiency rats after oral administration of Danggui Buxue Decoction by UPLC-TQ/MS.
Topics: Administration, Oral; Anemia; Animals; Caffeic Acids; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Female; Glucosides; Isoflavones; Male; Mass Spectrometry; Medicine, Chinese Traditional; Plant Extracts; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Tissue Distribution; Triterpenes | 2014 |
Astragalus injection protects cerebral ischemic injury by inhibiting neuronal apoptosis and the expression of JNK3 after cerebral ischemia reperfusion in rats.
Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Male; Mitogen-Activated Protein Kinase 10; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury; Saponins; Triterpenes | 2013 |
Astragaloside IV attenuates experimental autoimmune encephalomyelitis of mice by counteracting oxidative stress at multiple levels.
Topics: Animals; Antioxidants; Apoptosis Regulatory Proteins; CD11b Antigen; Cell Line; Cytokines; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Drugs, Chinese Herbal; Encephalomyelitis, Autoimmune, Experimental; Female; Forkhead Transcription Factors; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Inflammation; Mice; Multiple Sclerosis; Nerve Tissue Proteins; Nitric Oxide Synthase Type II; Nuclear Receptor Subfamily 1, Group F, Member 3; Oxidative Stress; Reactive Oxygen Species; RNA, Messenger; Saponins; T-Box Domain Proteins; Th1 Cells; Th17 Cells; Triterpenes | 2013 |
Astragaloside IV stimulates angiogenesis and increases nitric oxide accumulation via JAK2/STAT3 and ERK1/2 pathway.
Topics: Angiogenesis Inducing Agents; Cell Movement; Cell Proliferation; Cells, Cultured; Human Umbilical Vein Endothelial Cells; Humans; Janus Kinase 2; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Neovascularization, Physiologic; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Saponins; STAT3 Transcription Factor; Triterpenes | 2013 |
Astragaloside IV protects against cardiac hypertrophy via inhibiting the Ca2+/CaN signaling pathway.
Topics: Animals; Atrial Natriuretic Factor; Calcineurin; Calcium Signaling; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Drugs, Chinese Herbal; Lipopolysaccharides; Myocytes, Cardiac; Natriuretic Peptide, Brain; NFATC Transcription Factors; Rats; Saponins; Signal Transduction; Triterpenes | 2014 |
Pharmacokinetic-pharmacodynamic evaluation of the major component astragaloside IV on the immunomodulatory effects of Yu-ping-feng prescription.
Topics: Animals; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Immunologic Factors; Male; Medicine, Chinese Traditional; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2014 |
Inhibition of human neutrophil elastase by pentacyclic triterpenes.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Glycine; Humans; Kinetics; Leukocyte Elastase; Mice, Inbred BALB C; Molecular Docking Simulation; Pentacyclic Triterpenes; Pneumonia; Proton Magnetic Resonance Spectroscopy; Saponins; Smoking; Sulfonamides; Triterpenes; Ursolic Acid | 2013 |
Astragaloside IV inhibits doxorubicin-induced cardiomyocyte apoptosis mediated by mitochondrial apoptotic pathway via activating the PI3K/Akt pathway.
Topics: Adenosine Triphosphate; Animals; Apoptosis; bcl-Associated Death Protein; Cells, Cultured; Creatine Kinase, Mitochondrial Form; Cytochromes c; Doxorubicin; L-Lactate Dehydrogenase; Mitochondria; Mitochondrial Proton-Translocating ATPases; Myocytes, Cardiac; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Saponins; Succinate Dehydrogenase; Triterpenes | 2014 |
Astragalosides IV inhibits high glucose-induced cell apoptosis through HGF activation in cultured human tubular epithelial cells.
Topics: Apoptosis; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Activation; Epithelial Cells; Glucose; Hepatocyte Growth Factor; Humans; Kidney Tubules, Proximal; p38 Mitogen-Activated Protein Kinases; Saponins; Signal Transduction; Transforming Growth Factor beta; Triterpenes | 2014 |
[Between Hengshanhuangqi and Chuanhuangqi based on metabolomics and ITS2 sequences].
Topics: Astragalus propinquus; Base Sequence; DNA, Plant; DNA, Ribosomal Spacer; Glucosides; Isoflavones; Metabolomics; Plant Roots; Plants, Medicinal; Principal Component Analysis; Saponins; Sequence Analysis, DNA; Species Specificity; Triterpenes | 2013 |
Astragaloside IV attenuates inflammatory cytokines by inhibiting TLR4/NF-кB signaling pathway in isoproterenol-induced myocardial hypertrophy.
Topics: Animals; Anti-Inflammatory Agents; Cardiotonic Agents; Cells, Cultured; Hypertrophy, Left Ventricular; Interleukin-6; Isoproterenol; Male; Myocardium; Myocytes, Cardiac; NF-kappa B; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Toll-Like Receptor 4; Triterpenes; Tumor Necrosis Factor-alpha | 2013 |
Pharmacokinetic Interaction of astragaloside IV with atractylenolide I and prim-O-glucosylcimifugin in male Sprague Dawley rats.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Synergism; Drugs, Chinese Herbal; Lactones; Male; Medicine, Chinese Traditional; Monosaccharides; Rats; Rats, Sprague-Dawley; Saponins; Sesquiterpenes; Time Factors; Triterpenes; Xanthenes | 2014 |
Astragaloside IV possesses antiarthritic effect by preventing interleukin 1β-induced joint inflammation and cartilage damage.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Cartilage; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Interleukin-1beta; Male; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2014 |
Smith degradation, an efficient method for the preparation of cycloastragenol from astragaloside IV.
Topics: Acids; Astragalus propinquus; Chromatography, Liquid; Drugs, Chinese Herbal; Hydrolysis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Oxidation-Reduction; Sapogenins; Saponins; Triterpenes | 2014 |
Simultaneous determination of calycosin-7-O-β-d-glucoside, calycosin, formononetin, astragaloside IV and schisandrin in rat plasma by LC-MS/MS: application to a pharmacokinetic study after oral administration of Shenqi Wuwei chewable tablets.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Cyclooctanes; Drug Stability; Drugs, Chinese Herbal; Glucosides; Isoflavones; Lignans; Linear Models; Male; Polycyclic Compounds; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Sensitivity and Specificity; Tablets; Tandem Mass Spectrometry; Triterpenes | 2014 |
Beneficial effects of Astragaloside IV for hair loss via inhibition of Fas/Fas L-mediated apoptotic signaling.
Topics: Alopecia; Animals; Apoptosis; Caspase 3; Disease Models, Animal; Fas Ligand Protein; fas Receptor; Female; Hair Follicle; I-kappa B Proteins; Interleukin-1beta; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; Saponins; Signal Transduction; Triterpenes; Tumor Necrosis Factor-alpha | 2014 |
Astragaloside Ⅳ reduces the expression level of P-glycoprotein in multidrug-resistant human hepatic cancer cell lines.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Rhodamine 123; Saponins; Triterpenes | 2014 |
Anti-stress effect of astragaloside IV in immobilized mice.
Topics: Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents; Behavior, Animal; Corticosterone; Interleukin-6; Male; Mice, Inbred ICR; Phytotherapy; Restraint, Physical; Saponins; Stress, Psychological; Triterpenes; Tumor Necrosis Factor-alpha | 2014 |
Astragaloside IV prevents damage to human mesangial cells through the inhibition of the NADPH oxidase/ROS/Akt/NF‑κB pathway under high glucose conditions.
Topics: Antioxidants; Calcium; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucose; Humans; Mesangial Cells; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Oxidative Stress; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes; TRPC Cation Channels; TRPC6 Cation Channel | 2014 |
Astragaloside IV attenuates allergic inflammation by regulation Th1/Th2 cytokine and enhancement CD4(+)CD25(+)Foxp3 T cells in ovalbumin-induced asthma.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cytokines; Drugs, Chinese Herbal; Eosinophilia; Female; Flow Cytometry; Forkhead Transcription Factors; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-2 Receptor alpha Subunit; Interleukin-4; Lung; Mice, Inbred BALB C; Ovalbumin; Reverse Transcriptase Polymerase Chain Reaction; Saponins; T-Lymphocytes, Regulatory; Th1 Cells; Th2 Cells; Triterpenes | 2014 |
Simultaneous determination of calycosin-7-O-β-D-glucoside, ononin, calycosin, formononetin, astragaloside IV, and astragaloside II in rat plasma after oral administration of Radix Astragali extraction for their pharmacokinetic studies by ultra-pressure li
Topics: Administration, Oral; Animals; Astragalus propinquus; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Glucosides; Isoflavones; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry; Time Factors; Triterpenes | 2014 |
Astragaloside IV inhibits the up-regulation of Wnt/β-catenin signaling in rats with unilateral ureteral obstruction.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes; Up-Regulation; Ureteral Obstruction; Wnt Signaling Pathway | 2014 |
Beneficial effect of astragalosides on stroke condition using PC12 cells under oxygen glucose deprivation and reperfusion.
Topics: Animals; Cell Death; Cell Line; Cell Survival; Glucose; Mitochondria; Neuroprotective Agents; Oxygen; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Rats; Reperfusion Injury; Saponins; Stroke; Triterpenes | 2014 |
Astragaloside IV ameliorates diabetic nephropathy involving protection of podocytes in streptozotocin induced diabetic rats.
Topics: Animals; Cell Adhesion; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glomerular Basement Membrane; Integrin alpha3; Integrin beta1; Male; Microscopy, Electron, Transmission; Podocytes; Protective Agents; Protein Serine-Threonine Kinases; Rats, Sprague-Dawley; RNA, Messenger; Saponins; Triterpenes | 2014 |
Astragaloside IV inhibits renal tubulointerstitial fibrosis by blocking TGF-β/Smad signaling pathway in vivo and in vitro.
Topics: Animals; Disease Models, Animal; Fibrosis; Gene Expression Profiling; Kidney; Kidney Diseases; Kidney Function Tests; Rats, Sprague-Dawley; Saponins; Severity of Illness Index; Signal Transduction; Smad7 Protein; Transforming Growth Factor beta; Triterpenes | 2014 |
Protective effects of astragaloside IV against amyloid beta1-42 neurotoxicity by inhibiting the mitochondrial permeability transition pore opening.
Topics: Amyloid beta-Peptides; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cytochromes c; Humans; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neurons; Neuroprotective Agents; Neurotoxins; Peptide Fragments; Protein Conformation; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Saponins; Superoxides; Triterpenes | 2014 |
Astragaloside IV ameliorates renal fibrosis via the inhibition of mitogen-activated protein kinases and antiapoptosis in vivo and in vitro.
Topics: Animals; Apoptosis; Fibrosis; Humans; Kidney Diseases; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Saponins; Triterpenes | 2014 |
[Effects of astragalosides on PC12 cells injury and APP expression induced by dexamethasone and Abeta(25-35)].
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Astragalus Plant; Cell Survival; Dexamethasone; Drugs, Chinese Herbal; Ginsenosides; Neuroprotective Agents; PC12 Cells; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saponins; Triterpenes | 2013 |
Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking.
Topics: Antineoplastic Agents; bcl-X Protein; Cell Survival; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Computational Biology; Diosgenin; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Interleukin-2; Killer Cells, Natural; Medicine, Chinese Traditional; Molecular Docking Simulation; Protein Conformation; Saponins; Triterpenes; Tumor Necrosis Factor-alpha | 2014 |
Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO.
Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Line, Tumor; Coculture Techniques; Disease Progression; Drug Screening Assays, Antitumor; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice, Inbred C57BL; Neoplasm Transplantation; Paclitaxel; Saponins; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Regulatory; Triterpenes; Tryptophan; Tumor Burden; Tumor Escape | 2014 |
A comparative study on inhibition of total astragalus saponins and astragaloside IV on TNFR1-mediated signaling pathways in arterial endothelial cells.
Topics: Animals; Apoptosis; Arteries; Astragalus Plant; Caspase 3; Cells, Cultured; E-Selectin; Endothelial Cells; I-kappa B Proteins; Intercellular Adhesion Molecule-1; Mice; NF-KappaB Inhibitor alpha; Phosphorylation; Receptors, Tumor Necrosis Factor, Type I; Saponins; Signal Transduction; Transcription Factor RelA; Triterpenes; Tumor Necrosis Factor-alpha; Up-Regulation | 2014 |
Down-regulation of PERK-ATF4-CHOP pathway by Astragaloside IV is associated with the inhibition of endoplasmic reticulum stress-induced podocyte apoptosis in diabetic rats.
Topics: Activating Transcription Factor 4; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Down-Regulation; eIF-2 Kinase; Endoplasmic Reticulum Stress; Glucose; Heat-Shock Proteins; Male; Podocytes; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Saponins; Signal Transduction; Transcription Factor CHOP; Triterpenes | 2014 |
Astragaloside IV alleviates early brain injury following experimental subarachnoid hemorrhage in rats.
Topics: Animals; Brain Injuries; Male; Rats; Rats, Sprague-Dawley; Saponins; Subarachnoid Hemorrhage; Triterpenes | 2014 |
Protective effects of astragaloside IV against ovalbumin-induced lung inflammation are regulated/mediated by T-bet/GATA-3.
Topics: Animals; Asthma; Astragalus propinquus; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; GATA3 Transcription Factor; Interferon-gamma; Interleukin-4; Interleukin-5; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Pneumonia; RNA, Messenger; Saponins; Triterpenes | 2014 |
Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-α-ERK1/2-NF-κB pathway.
Topics: Astragalus propinquus; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Cytokines; Drugs, Chinese Herbal; Extracellular Matrix Proteins; Humans; Inflammation Mediators; Lung Neoplasms; MAP Kinase Signaling System; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Protein Kinase C; Saponins; Triterpenes | 2014 |
Ferulic acid combined with astragaloside IV protects against vascular endothelial dysfunction in diabetic rats.
Topics: Animals; Aorta, Abdominal; Coumaric Acids; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Drug Therapy, Combination; Endothelium, Vascular; Hypoglycemic Agents; Male; Molecular Structure; Rats, Wistar; Saponins; Triterpenes | 2014 |
HIF-1α signaling activation by post-ischemia treatment with astragaloside IV attenuates myocardial ischemia-reperfusion injury.
Topics: 2-Methoxyestradiol; Animals; Apoptosis; Caspase 3; Cells, Cultured; Drugs, Chinese Herbal; Estradiol; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-bcl-2; Rats; Saponins; Signal Transduction; Triterpenes; Up-Regulation | 2014 |
Astragaloside improves outcomes of traumatic brain injury in rats by reducing microglia activation.
Topics: Animals; Apoptosis; Brain; Brain Injuries; Disease Models, Animal; Drugs, Chinese Herbal; Injections, Intraperitoneal; Male; Microglia; Motor Activity; Phytotherapy; Rats, Sprague-Dawley; Saponins; Triterpenes; Tumor Necrosis Factor-alpha | 2014 |
Profiling the metabolism of astragaloside IV by ultra performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry.
Topics: Animals; Astragalus propinquus; Bile; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Feces; Male; Medicine, Chinese Traditional; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry; Triterpenes | 2014 |
Protective effects of astragaloside IV on db/db mice with diabetic retinopathy.
Topics: Aldehyde Reductase; Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electroretinography; MAP Kinase Signaling System; Mice; NF-kappa B; Phosphorylation; Retinal Ganglion Cells; Saponins; Triterpenes | 2014 |
Silk fibroin/gelatin electrospun nanofibrous dressing functionalized with astragaloside IV induces healing and anti-scar effects on burn wound.
Topics: Animals; Bandages; Burns; Cell Adhesion; Cicatrix; Collagen; Drug Delivery Systems; Fibroins; Gelatin; Nanofibers; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Saponins; Silk; Skin; Triterpenes; Wound Healing | 2015 |
Anti-fibrotic effects of Astragaloside IV in systemic sclerosis.
Topics: Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Humans; Mice; RNA, Messenger; Saponins; Scleroderma, Systemic; Smad3 Protein; Transforming Growth Factor beta; Triterpenes | 2014 |
EGFR mediates astragaloside IV-induced Nrf2 activation to protect cortical neurons against in vitro ischemia/reperfusion damages.
Topics: Animals; Antioxidants; Cerebral Cortex; Disease Models, Animal; Drugs, Chinese Herbal; ErbB Receptors; Gene Knockdown Techniques; Mice; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Primary Cell Culture; Reactive Oxygen Species; Reperfusion Injury; RNA, Messenger; Saponins; Transcriptional Activation; Triterpenes | 2015 |
Astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-β/Smad signaling suppression and inhibiting matrix metalloproteinase-1.
Topics: Cell Line; Cell Survival; Collagen; Fibroblasts; Gene Expression Regulation; Humans; Matrix Metalloproteinase 1; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Saponins; Signal Transduction; Skin Aging; Smad Proteins; Transforming Growth Factor beta; Triterpenes; Ultraviolet Rays | 2015 |
Astragaloside IV attenuates injury caused by myocardial ischemia/reperfusion in rats via regulation of toll-like receptor 4/nuclear factor-κB signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Down-Regulation; Male; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Toll-Like Receptor 4; Triterpenes | 2015 |
Astragaloside IV ameliorates acute pancreatitis in rats by inhibiting the activation of nuclear factor-κB.
Topics: Amylases; Animals; Antioxidants; Cytokines; Disease Models, Animal; Enzyme Activation; Inflammation Mediators; Lipase; Male; Necrosis; NF-kappa B; Pancreatitis; Peroxidase; Protein Transport; Rats; Saponins; Triterpenes | 2015 |
Ameliorating the effect of astragaloside IV on learning and memory deficit after chronic cerebral hypoperfusion in rats.
Topics: Animals; Antioxidants; Apoptosis; Calcium-Binding Proteins; Carotid Artery Diseases; Cerebrovascular Circulation; Chronic Disease; Drug Evaluation, Preclinical; Glial Fibrillary Acidic Protein; Hippocampus; Male; Maze Learning; Microfilament Proteins; Neuroglia; Neuroprotective Agents; Oxidative Stress; Rats, Sprague-Dawley; Saponins; Triterpenes | 2015 |
Remission of CVB3-induced myocarditis with Astragaloside IV treatment requires A20 (TNFAIP3) up-regulation.
Topics: Animals; Blotting, Western; Coxsackievirus Infections; Cysteine Endopeptidases; Drugs, Chinese Herbal; Echocardiography; Enterovirus; Heart; HEK293 Cells; HeLa Cells; Host-Pathogen Interactions; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Myocarditis; Myocardium; NF-kappa B; Remission Induction; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Saponins; Signal Transduction; Triterpenes; Tumor Necrosis Factor alpha-Induced Protein 3; Up-Regulation | 2015 |
Changes of peripheral-type benzodiazepine receptors in the penumbra area after cerebral ischemia-reperfusion injury and effects of astragaloside IV on rats.
Topics: Animals; Brain; Brain Ischemia; Female; Isoquinolines; Male; Mitochondria; Rats, Sprague-Dawley; Receptors, GABA-A; Reperfusion Injury; Saponins; Triterpenes; Tritium | 2015 |
Astragaloside IV protects against isoproterenol-induced cardiac hypertrophy by regulating NF-κB/PGC-1α signaling mediated energy biosynthesis.
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Down-Regulation; Energy Metabolism; Gene Knockdown Techniques; Heart Ventricles; Hemodynamics; Isoproterenol; Male; Mitochondria; Myocytes, Cardiac; Natriuretic Peptide, Brain; NF-kappa B; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Small Interfering; Saponins; Signal Transduction; Transcription Factor RelA; Transcription Factors; Triterpenes | 2015 |
Effect of astragaloside IV against rat myocardial cell apoptosis induced by oxidative stress via mitochondrial ATP-sensitive potassium channels.
Topics: Animals; Apoptosis; Astragalus propinquus; Cells, Cultured; Decanoic Acids; Hydrogen Peroxide; Hydroxy Acids; Medicine, Chinese Traditional; Membrane Potential, Mitochondrial; Myocytes, Cardiac; Oxidative Stress; Potassium Channels; Protective Agents; Rats; Rats, Wistar; Reactive Oxygen Species; Saponins; Triterpenes | 2015 |
Astragaloside IV prevents lipopolysaccharide-induced injury in H9C2 cardiomyocytes.
Topics: Animals; Antioxidants; Apoptosis; Cell Survival; Drugs, Chinese Herbal; Lipopolysaccharides; Myocytes, Cardiac; NF-kappa B; Rats; Saponins; Triterpenes; Tumor Necrosis Factor-alpha | 2015 |
[Stability study in biological samples and metabolites analysis of astragaloside IV in rat intestinal bacteria in vitro].
Topics: Animals; Bacteria; Chromatography, High Pressure Liquid; Drug Stability; Intestines; Liver; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry; Triterpenes | 2014 |
[Protective effect of astragaloside IV on oxidative damages of chang liver cell induced by ethanol and H2O2].
Topics: Antioxidants; Apoptosis; Cell Cycle; Cell Line; Cell Survival; Ethanol; Humans; Hydrogen Peroxide; Oxidative Stress; Reactive Oxygen Species; Saponins; Triterpenes | 2014 |
Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress.
Topics: Analysis of Variance; Animals; Apoptosis; Blotting, Western; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Male; Podocytes; Proteinuria; Random Allocation; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reference Values; Saponins; Streptozocin; Triterpenes; Urinalysis | 2015 |
Electrophysiological effect and the gating mechanism of astragaloside IV on L-type Ca(2+) channels of guinea-pig ventricular myocytes.
Topics: Animals; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Electrophysiological Phenomena; Guinea Pigs; Heart Ventricles; Ion Channel Gating; Myocytes, Cardiac; Saponins; Triterpenes | 2015 |
AST IV inhibits H₂O₂-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-β1/Smad2 pathway.
Topics: Apoptosis; Gene Expression Regulation, Enzymologic; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; NADPH Oxidase 4; NADPH Oxidases; Saponins; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta1; Triterpenes | 2015 |
Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium.
Topics: Apoptosis; Carrier Proteins; Caspase 3; Cells, Cultured; Endoplasmic Reticulum Stress; Endoribonucleases; Endothelial Cells; Humans; Inflammasomes; Membrane Potential, Mitochondrial; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Sapogenins; Saponins; Triterpenes | 2015 |
Compound Astragalus and Salvia miltiorrhiza extracts modulate MAPK-regulated TGF-β/Smad signaling in hepatocellular carcinoma by multi-target mechanism.
Topics: Alkenes; Animals; Astragalus propinquus; Carcinoma, Hepatocellular; Diethylnitrosamine; Down-Regulation; Gene Expression; Hep G2 Cells; Hepatic Stellate Cells; Humans; Karyopherins; Liver Neoplasms; Male; MAP Kinase Signaling System; Plant Extracts; Plasminogen Activator Inhibitor 1; Polyphenols; Polysaccharides; Rats; Receptors, Cytoplasmic and Nuclear; Salvia miltiorrhiza; Saponins; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta1; Triterpenes; Up-Regulation | 2015 |
Astragaloside IV inhibits NF- κ B activation and inflammatory gene expression in LPS-treated mice.
Topics: Animals; Astragalus propinquus; Chemokine CCL2; Female; Inflammation; Interleukin-6; Lipopolysaccharides; Lung; Mice; Mice, Inbred C57BL; Myocardium; NF-kappa B; Peroxidase; Saponins; Signal Transduction; Tissue Distribution; Toll-Like Receptor 4; Transcription Factor AP-1; Triterpenes; Tumor Necrosis Factor-alpha | 2015 |
Astragaloside IV Attenuates Glutamate-Induced Neurotoxicity in PC12 Cells through Raf-MEK-ERK Pathway.
Topics: Animals; Cell Differentiation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Profiling; Gene Expression Regulation; Glutamic Acid; High-Throughput Screening Assays; MAP Kinase Kinase Kinases; Molecular Sequence Annotation; Neurons; Neuroprotective Agents; PC12 Cells; Principal Component Analysis; Protein Interaction Mapping; raf Kinases; Rats; Saponins; Signal Transduction; Triterpenes | 2015 |
Antinociceptive activity of astragaloside IV in the animal model of chronic constriction injury.
Topics: Analgesics; Animals; Body Weight; Chronic Pain; Constriction, Pathologic; Disease Models, Animal; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Male; Motor Activity; Necrosis; Neural Conduction; Neuralgia; Rats, Sprague-Dawley; Saponins; Sciatic Nerve; Touch; Triterpenes | 2015 |
Dynamic variation of bioactive compounds and aflatoxins in contaminated Radix Astragali during extraction process.
Topics: Aflatoxins; Aspergillus flavus; Astragalus Plant; Food Contamination; Glucosides; Isoflavones; Saponins; Triterpenes | 2016 |
[Astragaloside IV regulates STAT1/IκB/NF-κB signaling pathway to inhibit activation of BV-2 cells].
Topics: Animals; Astragalus Plant; Drugs, Chinese Herbal; I-kappa B Proteins; Interferon-gamma; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Saponins; Signal Transduction; STAT1 Transcription Factor; Triterpenes | 2015 |
Enrichment and purification process of astragalosides and their anti-human gastric cancer MKN-74 cell proliferation effect.
Topics: Adsorption; Astragalus Plant; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Plant Extracts; Porosity; Resins, Synthetic; Saponins; Spectrophotometry, Ultraviolet; Stomach Neoplasms; Triterpenes | 2014 |
Disposition of Astragaloside IV via Enterohepatic Circulation Is Affected by the Activity of the Intestinal Microbiome.
Topics: Animals; Astragalus Plant; Bacteria; Drugs, Chinese Herbal; Enterohepatic Circulation; Gastrointestinal Microbiome; Intestinal Mucosa; Intestines; Male; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry; Triterpenes | 2015 |
[Inhibiting effects of three components of Astragalus membranaceus on oxidative stress in Chang Liver cells].
Topics: Astragalus propinquus; Cells, Cultured; Cytochrome P-450 CYP2E1; Humans; Isoflavones; Liver; Oxidative Stress; Reactive Oxygen Species; Saponins; Triterpenes | 2015 |
Effects of Astragaloside IV on diabetic nephropathy in rats.
Topics: Actinin; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Gene Expression Regulation; Humans; Integrin beta1; Kidney; Male; Protein Serine-Threonine Kinases; Rats; Saponins; Triterpenes | 2015 |
QiShenYiQi Pills, a compound in Chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multi-component and multi-target mode.
Topics: Animals; Cardiomegaly; Drugs, Chinese Herbal; Energy Metabolism; Gene Expression Regulation; Ginsenosides; Heart; Myocardium; Oxidative Stress; Pressure; Proteomics; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2015 |
Therapeutic angiogenesis in ischemic muscles after local injection of fragmented fibers with loaded traditional Chinese medicine.
Topics: Animals; Cell Line; Cell Proliferation; Disease Models, Animal; Drug Carriers; Hindlimb; Human Umbilical Vein Endothelial Cells; Humans; Immunohistochemistry; Ischemia; Medicine, Chinese Traditional; Mice, Nude; Muscle, Skeletal; Neovascularization, Physiologic; Saponins; Triterpenes | 2015 |
[Simultaneous Determination of Five Astragalosides in Astragali Radix and Jinqi Jiangtang Tablet by HPLC-ELSD].
Topics: Astragalus Plant; Astragalus propinquus; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Saponins; Tablets; Triterpenes | 2015 |
Astragaloside IV suppresses transforming growth factor-β1 induced fibrosis of cultured mouse renal fibroblasts via inhibition of the MAPK and NF-κB signaling pathways.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fibroblasts; Fibrosis; Kidney; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; NF-kappa B; Saponins; Transforming Growth Factor beta1; Triterpenes | 2015 |
Effects of Astragaloside IV Against the TGF-β1-Induced Epithelial-to-Mesenchymal Transition in Peritoneal Mesothelial Cells by Promoting Smad 7 Expression.
Topics: Actins; Cadherins; Cell Line; Cell Movement; Collagen Type I; Down-Regulation; Epithelial-Mesenchymal Transition; Epithelium; Gene Expression; Humans; Saponins; Signal Transduction; Smad7 Protein; Transforming Growth Factor beta1; Triterpenes; Up-Regulation; Vimentin | 2015 |
Inhibition of RANKL-induced osteoclastogenesis through the suppression of the ERK signaling pathway by astragaloside IV and attenuation of titanium-particle-induced osteolysis.
Topics: Animals; Cell Line; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Ligands; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Osteoclasts; Osteogenesis; Osteolysis; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Saponins; Titanium; Triterpenes | 2015 |
Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction.
Topics: Angiogenesis Inducing Agents; Animals; Coronary Vessels; Disease Models, Animal; Drug Evaluation, Preclinical; Fibroblast Growth Factor 2; Gene Expression; Male; Microvessels; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; Rats, Wistar; Saponins; Triterpenes; Vascular Endothelial Growth Factor A | 2015 |
Promotion of Astragaloside IV for EA-hy926 Cell Proliferation and Angiogenic Activity via ERK1/2 Pathway.
Topics: Angiogenesis Inducing Agents; Cell Line; Cell Proliferation; Cell Survival; Human Umbilical Vein Endothelial Cells; Humans; MAP Kinase Signaling System; Neovascularization, Physiologic; Saponins; Triterpenes; Vascular Endothelial Growth Factor A | 2015 |
Astragaloside IV protects against polymicrobial sepsis through inhibiting inflammatory response and apoptosis of lymphocytes.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Blotting, Western; Cytokines; Drugs, Chinese Herbal; Injections, Intravenous; Lymphocytes; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Phagocytes; Protective Agents; Random Allocation; Saponins; Sepsis; Triterpenes | 2016 |
Protective effect of astragaloside IV on lipopolysaccharide-induced cardiac dysfunction via downregulation of inflammatory signaling in mice.
Topics: Animals; Cytokines; Heart Diseases; Inflammation; Lipopolysaccharides; Mice; Myocardium; Oncogene Protein v-akt; Saponins; Signal Transduction; Transcription Factor RelA; Triterpenes | 2015 |
Beneficial effects of astragaloside IV against angiotensin II-induced mitochondrial dysfunction in rat vascular smooth muscle cells.
Topics: Adenosine Triphosphate; Angiotensin II; Animals; Antioxidants; Cells, Cultured; DNA, Mitochondrial; Male; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Diseases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Signal Transduction; Transcription Factors; Triterpenes | 2015 |
Astragaloside IV attenuates apoptosis of hypertrophic cardiomyocyte through inhibiting oxidative stress and calpain-1 activation.
Topics: 2-Propanol; Animals; Antioxidants; Apoptosis; Calpain; Cardiomegaly; Cardiotonic Agents; Cell Line; Gene Expression Regulation; Membrane Potential, Mitochondrial; Mitochondria; Myocytes, Cardiac; Oxidative Stress; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2015 |
Protective Effect of Astragaloside IV Against Paraquat-Induced Lung Injury in Mice by Suppressing Rho Signaling.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Catalase; Drugs, Chinese Herbal; Enzyme Activation; Glutathione Peroxidase; Interleukin-6; Lung; Malondialdehyde; Mice; Mice, Inbred BALB C; NF-kappa B; Oxidative Stress; Paraquat; Peroxidase; Random Allocation; rho GTP-Binding Proteins; rho-Associated Kinases; Saponins; Signal Transduction; Superoxide Dismutase; Thioredoxins; Triterpenes; Tumor Necrosis Factor-alpha | 2016 |
Effects of the Combination of the Main Active Components of Astragalus and Panax notoginseng on Inflammation and Apoptosis of Nerve Cell after Cerebral Ischemia-Reperfusion.
Topics: Animals; Apoptosis; Astragalus Plant; Brain Ischemia; CA1 Region, Hippocampal; Cell Survival; Disease Models, Animal; Drug Combinations; Endoplasmic Reticulum Chaperone BiP; Ginsenosides; Inflammation; Janus Kinase 1; Male; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; NF-kappa B; Panax notoginseng; Phytotherapy; Reperfusion Injury; Saponins; STAT1 Transcription Factor; Triterpenes | 2015 |
Therapeutic effect of astragaloside-IV on bradycardia is involved in up-regulating klotho expression.
Topics: Adrenergic beta-Agonists; Animals; Animals, Newborn; Bradycardia; Glucuronidase; Heart Function Tests; Heart Rate; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Isoproterenol; Klotho Proteins; Lipopolysaccharides; Myocytes, Cardiac; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes; Up-Regulation | 2016 |
Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Binding, Competitive; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Inflammation Mediators; Ligands; Lipopolysaccharides; Mice; Microglia; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; NF-kappa B; Protein Binding; Receptors, Glucocorticoid; Saponins; Signal Transduction; Toll-Like Receptors; Triterpenes | 2016 |
Regulation of drug-metabolizing enzymes and efflux transporters by Astragali radix decoction and its main bioactive compounds: Implication for clinical drug-drug interactions.
Topics: Astragalus propinquus; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Drug Interactions; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Isoflavones; Membrane Transport Proteins; RNA, Messenger; Saponins; Transferases; Triterpenes | 2016 |
Gastroprotective Effects of Astragaloside IV against Acute Gastric Lesion in Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Chemokine CCL2; Gastric Mucosa; HSP70 Heat-Shock Proteins; Male; Malondialdehyde; Omeprazole; Phospholipase C gamma; Rats; Rats, Sprague-Dawley; Saponins; Stomach Ulcer; Superoxide Dismutase; Triterpenes; Tumor Necrosis Factor-alpha | 2016 |
Astragaloside IV improves the isoproterenol-induced vascular dysfunction via attenuating eNOS uncoupling-mediated oxidative stress and inhibiting ROS-NF-κB pathways.
Topics: Animals; Anti-Inflammatory Agents; Aorta; Astragalus propinquus; Cardiomegaly; Cytokines; Humans; Isoproterenol; Male; NF-kappa B; Nitric Oxide Synthase Type III; Oxidative Coupling; Peripheral Vascular Diseases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes | 2016 |
Astragaloside IV suppresses inflammatory mediator production in synoviocytes and collagen‑induced arthritic rats.
Topics: Animals; Arthritis, Experimental; Cell Proliferation; Cells, Cultured; Collagen Type II; Cyclooxygenase 2; Cytokines; Down-Regulation; HMGB1 Protein; Inflammation Mediators; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; NF-kappa B; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Saponins; Synoviocytes; Triterpenes | 2016 |
Astragaloside IV enhances diabetic wound healing involving upregulation of alternatively activated macrophages.
Topics: Animals; Anti-Inflammatory Agents; Astragalus propinquus; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Extracellular Matrix; Humans; Macrophage Activation; Macrophages; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Saponins; Skin; Triterpenes; Wound Healing | 2016 |
Astragaloside IV, a Natural PPARγ Agonist, Reduces Aβ Production in Alzheimer's Disease Through Inhibition of BACE1.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cell Line, Tumor; Genes, Reporter; Humans; Ligands; Luciferases; Mice, Inbred C57BL; Mice, Transgenic; Plaque, Amyloid; Plasmids; PPAR gamma; Presenilin-1; Response Elements; Saponins; Transfection; Triterpenes | 2017 |
Astragaloside IV protects cardiomyocytes from anoxia/reoxygenation injury by upregulating the expression of Hes1 protein.
Topics: Animals; Animals, Newborn; Apoptosis; Astragalus propinquus; Cardiotonic Agents; Caspase 3; Cells, Cultured; Diamines; Drugs, Chinese Herbal; Enzyme Activation; Lipid Peroxidation; Membrane Potential, Mitochondrial; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Myocytes, Cardiac; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Notch1; Saponins; Signal Transduction; Thiazoles; Transcription Factor HES-1; Triterpenes; Up-Regulation | 2016 |
Astragaloside IV facilitates glucose transport in C2C12 myotubes through the IRS1/AKT pathway and suppresses the palmitate-induced activation of the IKK/IκBα pathway.
Topics: Animals; Biological Transport; Cell Line; Chemokine CCL2; Gene Expression Regulation; Glucose; Glucose Transporter Type 4; Hypoglycemic Agents; I-kappa B Kinase; Insulin Receptor Substrate Proteins; Insulin Resistance; Interleukin-6; Mice; Models, Biological; Muscle Fibers, Skeletal; NF-KappaB Inhibitor alpha; Palmitic Acid; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; Toll-Like Receptor 4; Triterpenes; Tumor Necrosis Factor-alpha | 2016 |
Astragaloside IV prevents high glucose-induced podocyte apoptosis via downregulation of TRPC6.
Topics: Apoptosis; Calcineurin; Cell Line, Transformed; Diabetic Nephropathies; Glucose; NFATC Transcription Factors; Podocytes; Saponins; Signal Transduction; Triterpenes; TRPC Cation Channels; TRPC6 Cation Channel | 2016 |
Astragaloside IV Inhibits the Inflammatory Injury of Chicken Type II Pneumocytes Induced by Avian Pathogenic Escherichia coli.
Topics: Actins; Alveolar Epithelial Cells; Animals; Bacterial Adhesion; Chickens; Cytokines; Escherichia coli; Escherichia coli Infections; Gene Expression Regulation; Inflammation; Inflammation Mediators; Saponins; Triterpenes | 2016 |
Astragaloside I Stimulates Osteoblast Differentiation Through the Wnt/β-catenin Signaling Pathway.
Topics: Cell Differentiation; Osteoblasts; Osteogenesis; Saponins; Triterpenes; Wnt Signaling Pathway | 2016 |
Astragaloside IV improves lipid metabolism in obese mice by alleviation of leptin resistance and regulation of thermogenic network.
Topics: Adipose Tissue; Animals; Body Weight; Cell Line; Diet, High-Fat; Gene Expression; Leptin; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Receptors, Leptin; Saponins; Thermogenesis; Triglycerides; Triterpenes; Weight Gain | 2016 |
Deacetylation biocatalysis and elicitation by immobilized Penicillium canescens in Astragalus membranaceus hairy root cultures: towards the enhanced and sustainable production of astragaloside IV.
Topics: Astragalus propinquus; Biocatalysis; Gene Expression Regulation, Plant; Penicillium; Plant Roots; Saponins; Triterpenes | 2017 |
Inhibitory Effects of Astragaloside IV on Bleomycin-Induced Pulmonary Fibrosis in Rats Via Attenuation of Oxidative Stress and Inflammation.
Topics: Animals; Bleomycin; Dose-Response Relationship, Drug; Inflammation; Oxidative Stress; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2016 |
Astragaloside IV alleviates E. coli-caused peritonitis via upregulation of neutrophil influx to the site of infection.
Topics: Animals; Anti-Infective Agents; Astragalus propinquus; Cell Movement; Escherichia coli; Escherichia coli Infections; G-Protein-Coupled Receptor Kinase 2; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Neutrophils; Peritonitis; Receptors, Interleukin-8B; Saponins; Triterpenes | 2016 |
Astragaloside IV attenuates inflammatory reaction via activating immune function of regulatory T-cells inhibited by HMGB1 in mice.
Topics: Animals; Cell Proliferation; Cells, Cultured; Coculture Techniques; Drugs, Chinese Herbal; HMGB1 Protein; Immunity, Cellular; Inflammation Mediators; Male; Mice; Mice, Inbred BALB C; Saponins; T-Lymphocytes, Regulatory; Triterpenes | 2016 |
Astragaloside IV ameliorates renal injury in db/db mice.
Topics: Acetylglucosamine; Albuminuria; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glomerular Filtration Rate; Glycated Hemoglobin; Hypertrophy; Kidney; Lipocalin-2; Liver; Mice; Phosphorylation; Saponins; Signal Transduction; Transforming Growth Factor beta1; Triterpenes | 2016 |
Tetramethylpyrazine and Astragaloside IV Synergistically Ameliorate Left Ventricular Remodeling and Preserve Cardiac Function in a Rat Myocardial Infarction Model.
Topics: Animals; Drug Synergism; Drug Therapy, Combination; Drugs, Chinese Herbal; Myocardial Infarction; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes; Vasodilator Agents; Ventricular Function, Left; Ventricular Remodeling | 2017 |
A positive correlation exists between neurotrauma and TGF-β1-containing microglia in rats.
Topics: Animals; Brain; Brain Contusion; Brain Injuries, Traumatic; Disease Models, Animal; Drugs, Chinese Herbal; Immunohistochemistry; Male; Microglia; Rats; Rats, Sprague-Dawley; Saponins; Transforming Growth Factor beta1; Triterpenes | 2016 |
Astragaloside IV protects rat gastric mucosa against aspirin-induced damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Female; Gastric Mucosa; Humans; Lipopolysaccharides; Male; Membrane Proteins; Nitric Oxide; Protective Agents; Rats, Wistar; Saponins; Stomach Ulcer; Superoxide Dismutase; Triterpenes | 2016 |
[Effect and mechanism of traditional Chinese herbs against Aβ expression in brain tissues of mice with Alzheimer's disease].
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzyl Alcohols; Brain; Disease Models, Animal; Glucosides; Hippocampus; Memory; Mice; Mice, Transgenic; Monoterpenes; Plaque, Amyloid; Random Allocation; Saponins; Triterpenes | 2016 |
Astragaloside IV from Astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting inflammation via TLR4/NF-кB in vivo and in vitro.
Topics: Animals; Anti-Inflammatory Agents; Astragalus propinquus; Cell Line; Fibrosis; Humans; Inflammation; Kidney; Kidney Diseases; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; NF-kappa B; Saponins; Signal Transduction; Toll-Like Receptor 4; Triterpenes; Ureteral Obstruction | 2017 |
Astragaloside IV ameliorates allergic inflammation by inhibiting key initiating factors in the initial stage of sensitization.
Topics: Animals; Cytokines; Humans; Hypersensitivity; Inflammation; Interleukin-33; Mice; Mice, Inbred BALB C; Saponins; Th2 Cells; Thymic Stromal Lymphopoietin; Triterpenes | 2016 |
Astragaloside IV inhibits breast cancer cell invasion by suppressing Vav3 mediated Rac1/MAPK signaling.
Topics: Animals; Antineoplastic Agents; Apoptosis; Astragalus propinquus; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drugs, Chinese Herbal; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Mice; Mice, Nude; Proto-Oncogene Proteins c-vav; rac1 GTP-Binding Protein; RNA, Small Interfering; Saponins; Signal Transduction; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays | 2017 |
[Inhibitory effect of jianpi-jiedu prescription-contained serum on colorectal cancer SW48 cell proliferation by mTOR-P53-P21 signalling pathway].
Topics: Animals; Apigenin; Blotting, Western; Cell Cycle; Cell Division; Cell Proliferation; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Drugs, Chinese Herbal; Flow Cytometry; Ginsenosides; Glycyrrhizic Acid; Humans; Lactones; Phosphorylation; RNA, Messenger; Saponins; Sesquiterpenes; Signal Transduction; TOR Serine-Threonine Kinases; Triterpenes; Tumor Suppressor Protein p53 | 2016 |
Astragaloside IV Enhances Cisplatin Chemosensitivity in Non-Small Cell Lung Cancer Cells Through Inhibition of B7-H3.
Topics: Apoptosis; B7 Antigens; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Cisplatin; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Saponins; Triterpenes | 2016 |
Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Cognitive Dysfunction; Disease Models, Animal; Inflammation; Ischemic Attack, Transient; Male; Mice; Neuroprotective Agents; NF-kappa B; Reperfusion; Saponins; Toll-Like Receptor 4; Triterpenes | 2017 |
Astragaloside IV inhibits metastasis in hepatoma cells through the suppression of epithelial-mesenchymal transition via the Akt/GSK-3β/β-catenin pathway.
Topics: beta Catenin; Blotting, Western; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Humans; Liver Neoplasms; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; Triterpenes; Tumor Cells, Cultured | 2017 |
Simultaneous Determination of Five Active Components in the Chinese Patent Medicine Niuhuang Jiangya Pill by HPLC-MS/MS.
Topics: Biological Products; China; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Emodin; Flavonoids; Glucosides; Monoterpenes; Saponins; Tandem Mass Spectrometry; Triterpenes | 2017 |
Simultaneous determination of eight bioactive components of Qishen Yiqi dripping pills in rat plasma using UFLC-MS/MS and its application to a pharmacokinetic study.
Topics: Alkenes; Animals; Benzaldehydes; Caffeic Acids; Catechols; Chromatography, High Pressure Liquid; Cinnamates; Depsides; Drugs, Chinese Herbal; Ginsenosides; Glucosides; Hydroxybenzoates; Isoflavones; Limit of Detection; Male; Polyphenols; Rats; Rats, Sprague-Dawley; Rosmarinic Acid; Saponins; Tandem Mass Spectrometry; Triterpenes | 2017 |
Astragaloside IV synergizes with ferulic acid to suppress hepatic stellate cells activation in vitro.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blotting, Western; Cell Proliferation; Cells, Cultured; Coumaric Acids; Drug Synergism; Hepatic Stellate Cells; Humans; In Vitro Techniques; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saponins; Transforming Growth Factor beta; Triterpenes | 2017 |
Astragaloside IV ameliorates 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis implicating regulation of energy metabolism.
Topics: Actins; Animals; Biomarkers; Cell Count; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Energy Metabolism; Immunohistochemistry; Inflammatory Bowel Diseases; Intestinal Mucosa; Proteolysis; Rats; Regional Blood Flow; Saponins; Stem Cells; Tight Junction Proteins; Trinitrobenzenesulfonic Acid; Triterpenes | 2017 |
Synergistic Inhibitory Effect of Traditional Chinese Medicine Astragaloside IV and Curcumin on Tumor Growth and Angiogenesis in an Orthotopic Nude-Mouse Model of Human Hepatocellular Carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cell Growth Processes; Curcumin; Disease Models, Animal; Down-Regulation; Drug Synergism; Hep G2 Cells; Heterografts; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Random Allocation; Saponins; Triterpenes | 2017 |
Synergism and mechanism of Astragaloside IV combined with Ginsenoside Rg1 against autophagic injury of PC12 cells induced by oxygen glucose deprivation/reoxygenation.
Topics: Animals; Apoptosis; Autophagy; Cell Hypoxia; Cell Survival; Drug Synergism; Ginsenosides; Glucose; L-Lactate Dehydrogenase; Neuroprotective Agents; PC12 Cells; Phagosomes; Rats; Saponins; Signal Transduction; Triterpenes | 2017 |
Astragaloside Alleviates Hepatic Fibrosis Function via PAR2 Signaling Pathway in Diabetic Rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Gene Expression Regulation; Interleukin-1beta; Interleukin-6; Liver Cirrhosis; Male; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Saponins; Signal Transduction; Streptozocin; Transforming Growth Factor beta1; Triterpenes; Tumor Necrosis Factor-alpha | 2017 |
Astragaloside IV inhibits isoprenaline‑induced cardiac fibrosis by targeting the reactive oxygen species/mitogen‑activated protein kinase signaling axis.
Topics: Animals; Astragalus Plant; Cell Proliferation; Collagen Type I; Female; Fibroblasts; Fibrosis; Heart; Isoproterenol; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Myocardium; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes | 2017 |
Astragaloside IV Enhances Cisplatin Chemosensitivity in Human Colorectal Cancer via Regulating NOTCH3.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Colorectal Neoplasms; HCT116 Cells; Humans; Receptor, Notch3; RNA, Messenger; Saponins; Triterpenes; Up-Regulation | 2016 |
Astragaloside IV attenuates lead acetate-induced inhibition of neurite outgrowth through activation of Akt-dependent Nrf2 pathway in vitro.
Topics: Animals; Gene Expression Regulation; Nerve Tissue Proteins; Neurites; NF-E2-Related Factor 2; Organometallic Compounds; PC12 Cells; Proto-Oncogene Proteins c-akt; Rats; Saponins; Signal Transduction; Triterpenes | 2017 |
Astragaloside IV Alleviates Lipopolysaccharide-Induced Acute Kidney Injury Through Down-Regulating Cytokines, CCR5 and p-ERK, and Elevating Anti-Oxidative Ability.
Topics: Acute Kidney Injury; Animals; Cytokines; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Interleukin-6; Kidney; Lipopolysaccharides; Male; Mice; Models, Animal; Reactive Oxygen Species; Receptors, CCR5; Saponins; Triterpenes; Tumor Necrosis Factor-alpha | 2017 |
Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation.
Topics: AMP-Activated Protein Kinases; Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Mice; Mice, Inbred C57BL; Molecular Conformation; Saponins; Structure-Activity Relationship; Triterpenes | 2017 |
Astragaloside IV inhibits PMA-induced EPCR shedding through MAPKs and PKC pathway.
Topics: Antigens, CD; Endothelial Protein C Receptor; Extracellular Signal-Regulated MAP Kinases; Human Umbilical Vein Endothelial Cells; Humans; MAP Kinase Signaling System; Protein Kinase C; Receptors, Cell Surface; Saponins; Tetradecanoylphorbol Acetate; Triterpenes | 2017 |
Compatibility of Tanshinone IIA and Astragaloside IV in attenuating hypoxia-induced cardiomyocytes injury.
Topics: Abietanes; Animals; Apoptosis; Cell Line; Cell Movement; Cell Survival; Cells, Cultured; Chemokines; Hypoxia; L-Lactate Dehydrogenase; Macrophages, Peritoneal; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Rats; RNA, Messenger; Saponins; Triterpenes | 2017 |
Astragaloside IV sensitizes non-small cell lung cancer cells to gefitinib potentially via regulation of SIRT6.
Topics: A549 Cells; Apoptosis; Astragalus propinquus; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Quinazolines; Saponins; Sirtuins; Triterpenes | 2017 |
Liquid chromatography-mass spectrometry-based quantitative proteomics analysis reveals chondroprotective effects of astragaloside IV in interleukin-1β-induced SW1353 chondrocyte-like cells.
Topics: Apoptosis; Blotting, Western; Cell Line; Chondrocytes; Chromatography, Liquid; Cluster Analysis; Collagen Type I, alpha 1 Chain; Gene Expression Regulation; Humans; Interleukin-1beta; Isotope Labeling; Mass Spectrometry; Protective Agents; Protein Sorting Signals; Proteomics; Reproducibility of Results; Saponins; Software; Triterpenes | 2017 |
AstragalosideⅣ against cardiac fibrosis by inhibiting TRPM7 channel.
Topics: Animals; Cell Differentiation; Cell Hypoxia; Cell Proliferation; Endomyocardial Fibrosis; Fibroblasts; Heart; Isoproterenol; Male; Mice; NIH 3T3 Cells; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes; TRPM Cation Channels; Up-Regulation | 2017 |
Immune regulation mechanism of Astragaloside IV on RAW264.7 cells through activating the NF-κB/MAPK signaling pathway.
Topics: Adolescent; Adult; Animals; Apoptosis; Child; Cytokines; Humans; Immunomodulation; Macrophages; MAP Kinase Signaling System; Mice; NF-kappa B; RAW 264.7 Cells; Saponins; Signal Transduction; Transcriptional Activation; Triterpenes; Young Adult | 2017 |
Astragaloside-IV Protects Against Heat-induced Apoptosis by Inhibiting Excessive Activation of Mitochondrial Ca2+ Uniporter.
Topics: Animals; Apoptosis; Calcium; Calcium Channels; Epithelial Cells; Hot Temperature; Membrane Potential, Mitochondrial; Mitochondria; Myocytes, Cardiac; Protective Agents; Rats; Reactive Oxygen Species; Saponins; Triterpenes | 2017 |
Astragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation.
Topics: Animals; Apoptosis Regulatory Proteins; Calcium; Cardiotonic Agents; Cell Respiration; Disease Models, Animal; Energy Metabolism; Enzyme Activation; Fatty Acids; Gene Expression Regulation; Glucose; Glycolysis; Heart Failure; Heart Function Tests; Hemodynamics; Male; Mice; Mitochondria, Heart; Oxidation-Reduction; PPAR alpha; Saponins; Triterpenes | 2017 |
Protective effects of astragaloside IV against ovalbumin-induced allergic rhinitis are mediated by T-box protein expressed in T cells/GATA-3 and forkhead box protein 3/retinoic acid-related orphan nuclear receptor γt.
Topics: Allergens; Animals; Biomarkers; Dexamethasone; Disease Models, Animal; DNA-Binding Proteins; Female; GATA3 Transcription Factor; Gene Expression Regulation; Immunoglobulin E; Male; Mice; Nasal Mucosa; Nerve Tissue Proteins; Nuclear Proteins; Nuclear Receptor Subfamily 1, Group F, Member 3; Ovalbumin; Protective Agents; Rhinitis, Allergic; RNA, Messenger; Saponins; Spleen; T-Box Domain Proteins; T-Lymphocyte Subsets; Triterpenes | 2017 |
Efficient Biotransformation of Astragaloside IV to Cycloastragenol by Bacillus sp. LG-502.
Topics: Bacillus; Biotransformation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Sapogenins; Saponins; Triterpenes | 2017 |
Astragaloside-IV Alleviates Heat-Induced Inflammation by Inhibiting Endoplasmic Reticulum Stress and Autophagy.
Topics: Animals; Apoptosis; Autophagy; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Hot Temperature; Inflammation; Rats; Rats, Wistar; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes | 2017 |
Astragaloside IV inhibits progression of glioma via blocking MAPK/ERK signaling pathway.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Glioma; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Saponins; Treatment Outcome; Triterpenes | 2017 |
Astragaloside IV downregulates the expression of MDR1 in Bel‑7402/FU human hepatic cancer cells by inhibiting the JNK/c‑Jun/AP‑1 signaling pathway.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Fluorouracil; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Saponins; Signal Transduction; Transcription Factor AP-1; Triterpenes | 2017 |
Astragaloside IV protects against apoptosis in human degenerative chondrocytes through autophagy activation.
Topics: Apoptosis; Autophagy; Cell Survival; Chondrocytes; Cytoprotection; Humans; Interleukin-1beta; Saponins; Triterpenes | 2017 |
Reduction of Ischemic Brain Edema by Combined use of Paeoniflorin and Astragaloside IV via Down-Regulating Connexin 43.
Topics: Animals; Aquaporin 4; Brain Edema; Brain Ischemia; Connexin 43; Down-Regulation; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Glucosides; JNK Mitogen-Activated Protein Kinases; Male; Monoterpenes; Rats, Sprague-Dawley; Saponins; Signal Transduction; Triterpenes | 2017 |
Astragalosidic Acid: A New Water-Soluble Derivative of Astragaloside IV Prepared Using Remarkably Simple TEMPO-Mediated Oxidation.
Topics: Animals; Cell Line; Cyclic N-Oxides; Mice; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidation-Reduction; Saponins; Triterpenes | 2017 |
Astragaloside IV protects against podocyte injury via SERCA2-dependent ER stress reduction and AMPKα-regulated autophagy induction in streptozotocin-induced diabetic nephropathy.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Apoptosis; Autophagy; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endoplasmic Reticulum Stress; Male; Mice; Mice, Inbred C57BL; Podocytes; Protein Kinases; Saponins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Triterpenes | 2017 |
Astragaloside IV ameliorates diabetic nephropathy by modulating the mitochondrial quality control network.
Topics: Albumins; Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Gene Expression Regulation; Gene Regulatory Networks; Male; Mice; Mitochondria; Mitochondrial Dynamics; Saponins; Triterpenes | 2017 |
[Effect of astragaloside on mRNA expression of PI3K/Akt/mTOR signal transduction in anemia model mice induced by chemotherapy].
Topics: Anemia; Animals; Cyclophosphamide; Male; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA, Messenger; Saponins; Signal Transduction; TOR Serine-Threonine Kinases; Triterpenes | 2016 |
The effect of Astragaloside IV on ethanol-induced gastric mucosal injury in rats: Involvement of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Cytokines; Disease Models, Animal; Ethanol; Gastritis; Humans; Inflammation Mediators; Intestines; Male; Neutrophils; NF-kappa B; Omeprazole; Peroxidase; Rats; Rats, Sprague-Dawley; Saponins; TNF Receptor-Associated Factor 2; Triterpenes; Tumor Necrosis Factor-alpha | 2017 |
Inhibition of cardiotrophin‑1 overexpression is involved in the anti‑fibrotic effect of Astrogaloside IV.
Topics: Animals; Cell Proliferation; Cells, Cultured; Collagen Type I; Cytokines; Fibrosis; Gene Expression Regulation; Gene Knockdown Techniques; Male; Myocardium; Myofibroblasts; Rats; Reactive Oxygen Species; RNA Interference; Saponins; Triterpenes | 2017 |
Astragaloside IV attenuates the H2O2-induced apoptosis of neuronal cells by inhibiting α-synuclein expression via the p38 MAPK pathway.
Topics: alpha-Synuclein; Antioxidants; Apoptosis; Cell Line; Humans; Hydrogen Peroxide; Neurons; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Saponins; Triterpenes | 2017 |
Astragaloside IV Induced miR-134 Expression Reduces EMT and Increases Chemotherapeutic Sensitivity by Suppressing CREB1 Signaling in Colorectal Cancer Cell Line SW-480.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Cyclic AMP Response Element-Binding Protein; Drugs, Chinese Herbal; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Organoplatinum Compounds; Oxaliplatin; Saponins; Signal Transduction; Triterpenes | 2017 |
Astragaloside IV attenuates penicillin-induced epilepsy via inhibiting activation of the MAPK signaling pathway.
Topics: Animals; Astrocytes; Cell Proliferation; Disease Models, Animal; Epilepsy; Humans; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Penicillins; Primary Cell Culture; Rats; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes | 2018 |
Astragaloside IV attenuates orbital inflammation in Graves' orbitopathy through suppression of autophagy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Cells, Cultured; Cytokines; Eye; Female; Fibroblasts; Graves Disease; Interleukin-1beta; Mice; Mice, Inbred BALB C; Orbit; RNA, Messenger; Saponins; Triterpenes | 2018 |
Chemosensitive effects of Astragaloside IV in osteosarcoma cells via induction of apoptosis and regulation of caspase-dependent Fas/FasL signaling.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bone Neoplasms; Caspases; Cell Line, Tumor; Cell Proliferation; Cisplatin; Fas Ligand Protein; fas Receptor; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Osteosarcoma; Saponins; Signal Transduction; Triterpenes; Xenograft Model Antitumor Assays | 2017 |
Astragaloside IV prevents kidney injury caused by iatrogenic hyperinsulinemia in a streptozotocin‑induced diabetic rat model.
Topics: Acute Kidney Injury; Animals; Antioxidants; Collagen Type IV; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Humans; Hyperinsulinism; Iatrogenic Disease; Oxidative Stress; Podocytes; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2018 |
[Effect of astragaloside Ⅳ combined with Panax notoginseng saponins on cerebral ischemia-reperfusion injury and study of pharmacokinetics in rats].
Topics: Animals; Chromatography, Liquid; Ginsenosides; Panax notoginseng; Plants, Medicinal; Rats; Reperfusion Injury; Saponins; Tandem Mass Spectrometry; Triterpenes | 2017 |
Astragaloside IV protects rat retinal capillary endothelial cells against high glucose-induced oxidative injury.
Topics: Animals; Antioxidants; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Glucose; Male; Molecular Conformation; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Retina; Saponins; Structure-Activity Relationship; Triterpenes | 2017 |
Astragaloside IV Prevents Cardiac Remodeling in the Apolipoprotein E-Deficient Mice by Regulating Cardiac Homeostasis and Oxidative Stress.
Topics: Animals; Apolipoproteins E; Apoptosis; Cardiomegaly; Cardiotonic Agents; Female; Fibrosis; Gene Deletion; Hypercholesterolemia; Lipids; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Oxidative Stress; Saponins; Transcriptome; Triterpenes; Ventricular Dysfunction, Left | 2017 |
NRF2/HO-1 activation via ERK pathway involved in the anti-neuroinflammatory effect of Astragaloside IV in LPS induced microglial cells.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Heme Oxygenase-1; Inflammation; Lipopolysaccharides; MAP Kinase Signaling System; Membrane Proteins; Mice; Microglia; NF-E2-Related Factor 2; Saponins; Triterpenes | 2018 |
Astragaloside IV protects blood-brain barrier integrity from LPS-induced disruption via activating Nrf2 antioxidant signaling pathway in mice.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; NF-E2-Related Factor 2; Random Allocation; Saponins; Signal Transduction; Triterpenes | 2018 |
Astragaloside IV inhibits ventricular remodeling and improves fatty acid utilization in rats with chronic heart failure.
Topics: Animals; Benzazepines; Chronic Disease; Chymases; Disease Models, Animal; Energy Metabolism; Fatty Acids; Heart Failure; Heart Ventricles; Humans; Myocardium; Myocytes, Cardiac; PPAR alpha; Rats; RNA, Messenger; Saponins; Triterpenes; Ventricular Remodeling | 2018 |
Astragaloside IV inhibits cell migration and viability of hepatocellular carcinoma cells via suppressing long noncoding RNA ATB.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Survival; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Interleukin-11; Liver Neoplasms; RNA, Long Noncoding; Saponins; STAT3 Transcription Factor; Triterpenes | 2018 |
Astragaloside VI and cycloastragenol-6-O-beta-D-glucoside promote wound healing in vitro and in vivo.
Topics: Animals; Astragalus Plant; Cell Line; Cell Proliferation; Drug Evaluation, Preclinical; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Glucosides; Humans; Keratinocytes; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Saponins; Skin; Triterpenes; Wound Healing | 2018 |
Astragaloside IV inhibits TGF-β1-induced epithelial-mesenchymal transition through inhibition of the PI3K/Akt/NF-κB pathway in gastric cancer cells.
Topics: Antigens, CD; Cadherins; Cell Line, Tumor; Cell Movement; Cell Survival; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; Stomach Neoplasms; Transcription Factor RelA; Transforming Growth Factor beta1; Triterpenes | 2018 |
Proliferation and committed differentiation into dopamine neurons of neural stem cells induced by the active ingredients of radix astragali.
Topics: Animals; Astragalus propinquus; C-Reactive Protein; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Drugs, Chinese Herbal; Glucosides; Hedgehog Proteins; Isoflavones; Neural Stem Cells; Nuclear Receptor Subfamily 4, Group A, Member 2; Rats, Sprague-Dawley; Saponins; Serum Amyloid P-Component; Triterpenes; Tyrosine 3-Monooxygenase; Up-Regulation | 2018 |
Application of TQSM polypharmacokinetics and its similarity approach to ascertain Q-marker by analyses of transitivity in vivo of five candidates in Buyanghuanwu injection.
Topics: Amygdalin; Animals; Biological Availability; Biomarkers; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Glucosides; Injections; Monoterpenes; Pyrazines; Rats, Wistar; Saponins; Triterpenes | 2018 |
Astragaloside IV Prevents Obesity-Associated Hypertension by Improving Pro-Inflammatory Reaction and Leptin Resistance.
Topics: Animals; Hypertension; Inflammation; Leptin; Male; Obesity; Rats; Rats, Wistar; Saponins; Triterpenes | 2018 |
Astragaloside IV inhibits Angiotensin II-stimulated proliferation of rat vascular smooth muscle cells via the regulation of CDK2 activity.
Topics: Angiotensin II; Animals; Atherosclerosis; Cell Line; Cyclin-Dependent Kinase 2; G1 Phase; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; S Phase; Saponins; Triterpenes; Vascular Remodeling | 2018 |
Buyang Huanwu Decoction ameliorates ischemic stroke by modulating multiple targets with multiple components: In vitro evidences.
Topics: Animals; Apoptosis; Brain Ischemia; Drugs, Chinese Herbal; Glucosides; Isoflavones; Male; Mice; Mice, Inbred BALB C; Monoterpenes; PC12 Cells; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Saponins; Stroke; Triterpenes | 2018 |
Astragaloside Ⅳ Protects Against Aβ1-42-induced Oxidative Stress, Neuroinflammation and Cognitive Impairment in Rats.
Topics: Animals; Catalase; Cognitive Dysfunction; Interleukin-1beta; Male; Maze Learning; Memory; Memory Disorders; Oxidative Stress; Rats; Rats, Sprague-Dawley; Saponins; Spatial Learning; Superoxide Dismutase; Triterpenes; Tumor Necrosis Factor-alpha | 2018 |
Protective role of astragalus injection in spinal cord ischemia-reperfusion injury in rats.
Topics: Animals; Aquaporin 4; Astragalus Plant; Neuroprotective Agents; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins; Spinal Cord; Spinal Cord Injuries; Triterpenes | 2018 |
Novel mathematic models for quantitative transitivity of quality-markers in extraction process of the Buyanghuanwu decoction.
Topics: Amygdalin; Biomarkers, Pharmacological; Chemical Fractionation; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Glucosides; Kinetics; Models, Theoretical; Monoterpenes; Saponins; Triterpenes | 2018 |
Astragalosides increase the cardiac diastolic function and regulate the "Calcium sensing receptor-protein kinase C-protein phosphatase 1" pathway in rats with heart failure.
Topics: Animals; Animals, Newborn; Blood Pressure; Cells, Cultured; Diastole; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Heart Failure; Male; Protein Kinase C-alpha; Protein Phosphatase 1; Random Allocation; Rats; Rats, Wistar; Receptors, Calcium-Sensing; Saponins; Triterpenes | 2018 |
Astragaloside IV inhibits cell proliferation of colorectal cancer cell lines through down-regulation of B7-H3.
Topics: B7 Antigens; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Cyclin D1; Cyclin-Dependent Kinase 4; Down-Regulation; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Resting Phase, Cell Cycle; RNA, Messenger; Saponins; Triterpenes; Up-Regulation | 2018 |
The gastric mucosal protective effects of astragaloside IV in mnng-induced GPL rats.
Topics: Adenocarcinoma; Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Gastric Mucosa; Hyperplasia; Metaplasia; Methylnitronitrosoguanidine; Precancerous Conditions; Protective Agents; Rats; Rats, Sprague-Dawley; Saponins; Stomach; Stomach Neoplasms; Triterpenes | 2018 |
Astragaloside suppresses apoptosis of the podocytes in rats with diabetic nephropathy via miR-378/TRAF5 signaling pathway.
Topics: Albuminuria; Animals; Apoptosis; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; In Situ Nick-End Labeling; Male; Mice; MicroRNAs; Podocytes; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Saponins; Signal Transduction; TNF Receptor-Associated Factor 5; Transfection; Triterpenes | 2018 |
Astragaloside IV protects against the pathological cardiac hypertrophy in mice.
Topics: Angiotensin II; Animals; Apoptosis; Cardiomegaly; Cardiotonic Agents; Enzyme Activation; Inflammation; Intracellular Signaling Peptides and Proteins; Male; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Phosphorylation; Pressure; Protein Serine-Threonine Kinases; Saponins; Signal Transduction; Triterpenes | 2018 |
Astragaloside IV ameliorates neuroinflammation-induced depressive-like behaviors in mice via the PPARγ/NF-κB/NLRP3 inflammasome axis.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Depressive Disorder, Major; Hippocampus; Inflammasomes; Inflammation; Male; Mice, Inbred ICR; Saponins; Signal Transduction; Triterpenes | 2018 |
The Extracts and Major Compounds Derived from Astragali Radix Alter Mitochondrial Bioenergetics in Cultured Cardiomyocytes: Comparison of Various Polar Solvents and Compounds.
Topics: Animals; Antioxidants; Astragalus propinquus; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Electron Transport; Genistein; Mitochondria; Myocytes, Cardiac; Oxidative Phosphorylation; Oxygen Consumption; Plant Extracts; Rats; Saponins; Solvents; tert-Butylhydroperoxide; Triterpenes | 2018 |
Astragaloside IV ameliorates early diabetic nephropathy by inhibition of MEK1/2-ERK1/2-RSK2 signaling in streptozotocin-induced diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drugs, Chinese Herbal; Kidney; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Protective Agents; Saponins; Triterpenes | 2018 |
Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome.
Topics: Animals; Cardiovascular Diseases; Cells, Cultured; Disease Models, Animal; Drugs, Chinese Herbal; Fibroblasts; Fibrosis; Heart; Humans; Inflammasomes; Isoproterenol; Male; Mice; Mice, Inbred BALB C; Myocardium; NLR Family, Pyrin Domain-Containing 3 Protein; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Sapogenins; Saponins; Triterpenes | 2018 |
Astragaloside IV Inhibits Cigarette Smoke-Induced Pulmonary Inflammation in Mice.
Topics: Animals; Cells, Cultured; Cigarette Smoking; Female; Janus Kinase 3; Lung Injury; Mice; NF-kappa B; Pneumonia; Pulmonary Disease, Chronic Obstructive; Saponins; STAT3 Transcription Factor; Triterpenes | 2018 |
Astragaloside IV modulates TGF-β1-dependent epithelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis.
Topics: A549 Cells; Animals; Bleomycin; Drugs, Chinese Herbal; Epithelial Cells; Epithelial-Mesenchymal Transition; Forkhead Box Protein O3; Gene Expression Regulation; Humans; Lung; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Fibrosis; Rats; Saponins; Signal Transduction; Transforming Growth Factor beta1; Treatment Outcome; Triterpenes | 2018 |
Astragaloside IV Improves Vasodilatation Function by Regulating the PI3K/Akt/eNOS Signaling Pathway in Rat Aorta Endothelial Cells.
Topics: Animals; Aorta; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; In Vitro Techniques; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Saponins; Signal Transduction; Triterpenes; Vasodilation; Vasodilator Agents | 2018 |
Protective Effects of Astragaloside IV on Delayed Cerebral Vasospasm in an Experimental Rat Model of Subarachnoid Hemorrhage.
Topics: Animals; Disease Models, Animal; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Saponins; Subarachnoid Hemorrhage; Treatment Outcome; Triterpenes; Vasospasm, Intracranial | 2018 |
RETRACTED: Astragaloside IV reduces the hypoxia-induced injury in PC-12 cells by inhibiting expression of miR-124.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Proliferation; Cytoprotection; Cytoskeletal Proteins; DNA-Binding Proteins; Down-Regulation; LIM Domain Proteins; MicroRNAs; Neurons; Neuroprotective Agents; PC12 Cells; Rats; Saponins; Signal Transduction; Sp1 Transcription Factor; Survivin; Triterpenes | 2018 |
Astragaloside IV improves vascular endothelial dysfunction by inhibiting the TLR4/NF-κB signaling pathway.
Topics: Animals; Cytokines; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Endothelium, Vascular; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Toll-Like Receptor 4; Triterpenes | 2018 |
Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway.
Topics: Acetaminophen; Animals; Antioxidants; Biopsy; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Inflammation Mediators; Liver Function Tests; Male; Mice; Molecular Structure; NF-E2-Related Factor 2; Oxidative Stress; Saponins; Signal Transduction; Triterpenes | 2018 |
Astragaloside IV improves renal function and fibrosis via inhibition of miR-21-induced podocyte dedifferentiation and mesangial cell activation in diabetic mice.
Topics: Animals; Cell Dedifferentiation; Diabetic Nephropathies; Fibrosis; Kidney; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; MicroRNAs; Podocytes; Saponins; Triterpenes | 2018 |
Astragaloside IV Inhibits the Progression of Non-Small Cell Lung Cancer Through the Akt/GSK-3β/β-Catenin Pathway.
Topics: Apoptosis; beta Catenin; Biomarkers; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Disease Progression; Glycogen Synthase Kinase 3 beta; Humans; Lung Neoplasms; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; Triterpenes | 2019 |
Astragaloside IV inhibits lung cancer progression and metastasis by modulating macrophage polarization through AMPK signaling.
Topics: A549 Cells; AMP-Activated Protein Kinase Kinases; Cell Polarity; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Interleukin-13; Lung Neoplasms; Macrophages; Neoplasm Metastasis; Protein Kinases; Saponins; Signal Transduction; Triterpenes; Vesicular Transport Proteins | 2018 |
Astragaloside IV Promotes Adult Neurogenesis in Hippocampal Dentate Gyrus of Mouse through CXCL1/CXCR2 Signaling.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chemokine CXCL1; Dentate Gyrus; Doublecortin Protein; Male; Mice; Neurogenesis; Receptors, Interleukin-8B; Saponins; Signal Transduction; Triterpenes; Up-Regulation | 2018 |
Effect of astragaloside IV on indoxyl sulfate-induced kidney injury in mice via attenuation of oxidative stress.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Deoxyguanosine; Indican; Interleukin-1beta; Interleukin-6; Kidney; Kidney Diseases; Male; Malondialdehyde; Mice, Inbred C57BL; Oxidative Stress; Saponins; Superoxide Dismutase; Triterpenes | 2018 |
Effect of Combined Use of Astragaloside IV (AsIV) and Atorvastatin (AV) on Expression of PPAR-γ and Inflammation-Associated Cytokines in Atherosclerosis Rats.
Topics: Animals; Atherosclerosis; Atorvastatin; China; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Inflammation; Interleukin-18; Interleukin-6; Lipoproteins, HDL; Lipoproteins, LDL; Male; PPAR gamma; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Triterpenes; Tumor Necrosis Factor-alpha | 2018 |
Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy.
Topics: Animals; Antioxidants; Autophagy; Cell Survival; Cellular Senescence; Collagen Type I; Fibroblasts; MAP Kinase Signaling System; Oxidative Stress; Quercetin; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Skin; Skin Aging; Triterpenes; Ultraviolet Rays | 2018 |
Astragaloside IV/lncRNA-TUG1/TRAF5 signaling pathway participates in podocyte apoptosis of diabetic nephropathy rats.
Topics: Animals; Apoptosis; Cells, Cultured; Diabetic Nephropathies; Male; Mice; Podocytes; Rats; Rats, Sprague-Dawley; RNA, Long Noncoding; Saponins; Signal Transduction; Streptozocin; Structure-Activity Relationship; TNF Receptor-Associated Factor 5; Triterpenes | 2018 |
Astragali radix and its main bioactive compounds activate the Nrf2-mediated signaling pathway to induce P-glycoprotein and breast cancer resistance protein.
Topics: Adenosine Triphosphate; Animals; Astragalus propinquus; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drugs, Chinese Herbal; Hep G2 Cells; Herb-Drug Interactions; Humans; Isoflavones; Liver; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Saponins; Triterpenes | 2019 |
Astragalosides IV protected the renal tubular epithelial cells from free fatty acids-induced injury by reducing oxidative stress and apoptosis.
Topics: Apoptosis; Caspase 3; Cell Line; Diabetes Mellitus, Type 2; Epithelial Cells; Fatty Acids, Nonesterified; Glucose; Humans; Kidney Tubules; Oxidation-Reduction; Oxidative Stress; Protective Agents; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes | 2018 |
Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB p65 subunit.
Topics: Acetylation; Animals; Autophagy; Cell Proliferation; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; Saponins; Sirtuin 1; Structure-Activity Relationship; Transcription Factor RelA; Triterpenes | 2018 |
Astragaloside IV Protects Rat Cardiomyocytes from Hypoxia-Induced Injury by Down-Regulation of miR-23a and miR-92a.
Topics: Animals; Antagomirs; Apoptosis; Blood Pressure; Cell Hypoxia; Cell Line; Down-Regulation; Male; MicroRNAs; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Protective Agents; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Triterpenes | 2018 |
Astragaloside suppresses tumor necrosis factor receptor-associated factor 5 signaling pathway and alleviates neurodegenerative changes in retinal pigment epithelial cells induced by isoflurane.
Topics: Adolescent; Adult; Animals; Astragalus propinquus; Behavior, Animal; Cell Cycle Checkpoints; Cell Survival; Cognition; Drugs, Chinese Herbal; Epithelial Cells; Gene Expression; Humans; Isoflurane; NF-kappa B p50 Subunit; Oxidative Stress; Rats; Rats, Sprague-Dawley; Retinal Pigment Epithelium; Saponins; Signal Transduction; TNF Receptor-Associated Factor 5; Triterpenes; Young Adult | 2019 |
Molecular modeling investigation of the potential mechanism for phytochemical-induced skin collagen biosynthesis by inhibition of the protein phosphatase 1 holoenzyme.
Topics: Binding Sites; Biphenyl Compounds; Catalytic Domain; Collagen; Enzyme Inhibitors; Humans; Isoflavones; Molecular Docking Simulation; Molecular Dynamics Simulation; Phenyl Ethers; Phytochemicals; Protein Phosphatase 1; Saponins; Skin; Triterpenes | 2019 |
Pharmacokinetics Comparison, Intestinal Absorption and Acute Toxicity Assessment of a Novel Water-Soluble Astragaloside IV Derivative (Astragalosidic Acid, LS-102).
Topics: Administration, Oral; Animals; Benzoxazoles; Biological Transport; Caco-2 Cells; Female; Humans; Intestinal Absorption; Male; Mice; Mice, Inbred BALB C; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins; Solubility; Tandem Mass Spectrometry; Triazines; Triterpenes; Water | 2019 |
Astragaloside IV reversed the autophagy and oxidative stress induced by the intestinal microbiota of AIS in mice.
Topics: Animals; Antioxidants; Autophagy; Autophagy-Related Protein 12; Bacteria; Beclin-1; Brain; Disease Models, Animal; Fatty Acids; Feces; Gastrointestinal Microbiome; Genetic Vectors; Glutathione; Homocysteine; Ischemic Attack, Transient; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; NADPH Oxidase 2; NADPH Oxidase 4; Oxidative Stress; Reactive Oxygen Species; Saponins; Stroke; Superoxide Dismutase; Triterpenes | 2018 |
Protective effects of Astragaloside IV on endoplasmic reticulum stress-induced renal tubular epithelial cells apoptosis in type 2 diabetic nephropathy rats.
Topics: Activating Transcription Factor 4; Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dose-Response Relationship, Drug; Down-Regulation; eIF-2 Kinase; Endoplasmic Reticulum Stress; Epithelial Cells; Male; Rats; Rats, Sprague-Dawley; Saponins; Streptozocin; Transcription Factor CHOP; Triterpenes | 2019 |
Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-β1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy.
Topics: Administration, Oral; Animals; Central Nervous System Agents; Diabetic Nephropathies; Drugs, Chinese Herbal; Fibrosis; Ginsenosides; Male; Oxidative Stress; Rats; Rats, Wistar; Saponins; Signal Transduction; Smad2 Protein; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta1; Triterpenes | 2018 |
Astragaloside IV inhibits human colorectal cancer cell growth.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; HT29 Cells; Humans; Mice, Inbred BALB C; Mice, Nude; Phytotherapy; Saponins; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays | 2019 |
Protective Effects of Astragaloside IV Combined with Budesonide in Bronchitis in Rats by Regulation of Nrf2/Keap1 Pathway.
Topics: Animals; Bronchitis; Budesonide; Drug Combinations; Female; Glutathione Peroxidase; Kelch-Like ECH-Associated Protein 1; Lung; Male; Malondialdehyde; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Superoxide Dismutase; Triterpenes | 2018 |
Astragaloside IV ameliorates high glucose‑induced renal tubular epithelial‑mesenchymal transition by blocking mTORC1/p70S6K signaling in HK‑2 cells.
Topics: Actins; Cadherins; Cell Line; Collagen Type IV; Drugs, Chinese Herbal; Epithelial-Mesenchymal Transition; Fibronectins; Glucose; Humans; Kidney Tubules; Mechanistic Target of Rapamycin Complex 1; Ribosomal Protein S6 Kinases, 70-kDa; Saponins; Sweetening Agents; Triterpenes | 2019 |
Astragaloside IV reduces neuronal apoptosis and parthanatos in ischemic injury by preserving mitochondrial hexokinase-II.
Topics: Animals; Apoptosis Inducing Factor; Astragalus propinquus; Female; Gene Expression Regulation; Glutamic Acid; Hexokinase; Humans; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neurons; Neuroprotective Agents; Oxygen Consumption; Parthanatos; Primary Cell Culture; Protein Binding; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2019 |
Association of astragaloside IV-inhibited autophagy and mineralization in vascular smooth muscle cells with lncRNA H19 and DUSP5-mediated ERK signaling.
Topics: Animals; Atherosclerosis; Autophagy; Autophagy-Related Proteins; Cells, Cultured; Disease Models, Animal; Dual-Specificity Phosphatases; Extracellular Signal-Regulated MAP Kinases; Humans; Mice, Inbred C57BL; Mice, Knockout, ApoE; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Plaque, Atherosclerotic; RNA, Long Noncoding; Saponins; Signal Transduction; TOR Serine-Threonine Kinases; Triterpenes; Vascular Calcification | 2019 |
Astragaloside IV promotes the proliferation and migration of osteoblast-like cells through the hedgehog signaling pathway.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Antagonism; Drugs, Chinese Herbal; Hedgehog Proteins; Humans; Molecular Targeted Therapy; Osseointegration; Osteoblasts; Osteogenesis; Saponins; Signal Transduction; Triterpenes; Veratrum Alkaloids; Zinc Finger Protein GLI1 | 2019 |
Astragaloside IV inhibits cell proliferation in vulvar squamous cell carcinoma through the TGF-β/Smad signaling pathway.
Topics: Apoptosis; Autophagy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Female; G1 Phase Cell Cycle Checkpoints; Humans; Saponins; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Triterpenes; Vulvar Neoplasms | 2019 |
In Vitro Neuroprotection of Rat Hippocampal Neurons by Manninotriose and Astragaloside IV Against Corticosterone-Induced Toxicity.
Topics: Animals; Cells, Cultured; Corticosterone; Drug Antagonism; Hippocampus; Learning; Memory; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Saponins; Trisaccharides; Triterpenes | 2018 |
Astragaloside IV prevents high glucose‑induced cell apoptosis and inflammatory reactions through inhibition of the JNK pathway in human umbilical vein endothelial cells.
Topics: Apoptosis; Astragalus propinquus; Cell Proliferation; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; MAP Kinase Signaling System; Saponins; Signal Transduction; Triterpenes | 2019 |
Astragaloside IV ameliorates endoplasmic reticulum stress‑induced apoptosis of Aβ25‑35‑treated PC12 cells by inhibiting the p38 MAPK signaling pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cell Survival; Disease Models, Animal; Endoplasmic Reticulum Stress; Humans; Malondialdehyde; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Peptide Fragments; Rats; Reactive Oxygen Species; Saponins; Signal Transduction; Superoxide Dismutase; Triterpenes | 2019 |
Determination of a astragaloside IV derivative LS-102 in plasma by ultra-performance liquid chromatography-tandem mass spectrometry in dog plasma and its application in a pharmacokinetic study.
Topics: Administration, Oral; Animals; Astragalus propinquus; Benzoxazoles; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dogs; Doxorubicin; Drug Stability; Drugs, Chinese Herbal; Female; Half-Life; Male; Myocytes, Cardiac; Rats; Reproducibility of Results; Saponins; Tandem Mass Spectrometry; Triazines; Triterpenes | 2019 |
Protective Effects of Astragaloside IV against LPS-Induced Endometritis in Mice through Inhibiting Activation of the NF-κB, p38 and JNK Signaling Pathways.
Topics: Animals; Biomarkers; Cytokines; Endometritis; Female; Immunohistochemistry; Inflammation Mediators; Lipopolysaccharides; MAP Kinase Signaling System; Mice; NF-kappa B; Nitric Oxide; Protective Agents; Saponins; Toll-Like Receptor 4; Triterpenes | 2019 |
Astragaloside IV inhibits glucose-induced epithelial-mesenchymal transition of podocytes through autophagy enhancement via the SIRT-NF-κB p65 axis.
Topics: Animals; Autophagy; Cell Line; Diabetic Nephropathies; Disease Models, Animal; Epithelial-Mesenchymal Transition; Glucose; Kidney Function Tests; Mice; Models, Biological; Podocytes; Saponins; Sirtuin 1; Transcription Factor RelA; Treatment Outcome; Triterpenes | 2019 |
Astragaloside IV Alleviates Ammonia-Induced Apoptosis and Oxidative Stress in Bovine Mammary Epithelial Cells.
Topics: Ammonia; Animals; Apoptosis; Cattle; Endoplasmic Reticulum Stress; Epithelial Cells; Female; Humans; Mammary Glands, Human; Oxidative Stress; Phosphorylation; Reactive Oxygen Species; RNA, Messenger; Saponins; Signal Transduction; Triterpenes | 2019 |
Astragaloside IV Protects Primary Cerebral Cortical Neurons from Oxygen and Glucose Deprivation/Reoxygenation by Activating the PKA/CREB Pathway.
Topics: Animals; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cytoprotection; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Glucose; Neurons; Oxygen; Pregnancy; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Triterpenes | 2019 |
P-glycoprotein Inhibitor Tariquidar Potentiates Efficacy of Astragaloside IV in Experimental Autoimmune Encephalomyelitis Mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blood-Brain Barrier; Cell Line; Drug Synergism; Encephalomyelitis, Autoimmune, Experimental; Endothelial Cells; Female; Mice; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Quinolines; Saponins; Substrate Specificity; Triterpenes | 2019 |
Astragaloside IV inhibits palmitate-mediated oxidative stress and fibrosis in human glomerular mesangial cells via downregulation of CD36 expression.
Topics: Animals; CD36 Antigens; Diabetic Nephropathies; Diet, High-Fat; Down-Regulation; Fatty Acids, Nonesterified; Fibrosis; Humans; Male; Mesangial Cells; Oxidative Stress; Palmitates; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Transforming Growth Factor beta1; Triterpenes | 2019 |
Astragaloside IV protects against cisplatin-induced liver and kidney injury via autophagy-mediated inhibition of NLRP3 in rats.
Topics: Animals; Antineoplastic Agents; Autophagy; Chemical and Drug Induced Liver Injury; Cisplatin; Kidney; Liver; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Protective Agents; Rats, Sprague-Dawley; Saponins; Triterpenes | 2019 |
Astragaloside IV promotes the eNOS/NO/cGMP pathway and improves left ventricular diastolic function in rats with metabolic syndrome.
Topics: Animals; Aspartate Aminotransferases; Biomarkers; Blood Pressure; Body Weight; Cyclic GMP; Diastole; Diet, High-Fat; Electrocardiography; Fructose; Glucose; Hemodynamics; Insulin; Lipid Metabolism; Male; Metabolic Syndrome; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Protein Multimerization; Rats, Sprague-Dawley; Saponins; Signal Transduction; Systole; Triglycerides; Triterpenes; Ventricular Function, Left | 2020 |
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Cell Hypoxia; Cell Survival; Cells, Cultured; Heme Oxygenase-1; Inflammation; Myocardial Reperfusion Injury; Myocytes, Cardiac; NF-E2-Related Factor 2; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Repressor Proteins; Saponins; Signal Transduction; Triterpenes | 2019 |
Astragaloside IV inhibits the invasion and metastasis of SiHa cervical cancer cells via the TGF‑β1‑mediated PI3K and MAPK pathways.
Topics: Animals; Astragalus propinquus; Cell Line, Tumor; Cell Movement; Drugs, Chinese Herbal; Epithelial-Mesenchymal Transition; Female; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Saponins; Transforming Growth Factor beta1; Triterpenes; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2019 |
Astragaloside IV Protects Against Oxidized Low-Density Lipoprotein (ox-LDL)-Induced Endothelial Cell Injury by Reducing Oxidative Stress and Inflammation.
Topics: Antioxidants; Apoptosis; Cell Movement; Cell Survival; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; L-Lactate Dehydrogenase; Lipoproteins, LDL; NADP; NADPH Oxidases; Oxidative Stress; Protective Agents; Reactive Oxygen Species; Saponins; Triterpenes; Tumor Necrosis Factor-alpha | 2019 |
Astragaloside IV alleviates heart failure by promoting angiogenesis through the JAK-STAT3 pathway.
Topics: Angiogenesis Inducing Agents; Animals; Coronary Vessels; Disease Models, Animal; Heart Failure; Human Umbilical Vein Endothelial Cells; Humans; Janus Kinases; Kaplan-Meier Estimate; Male; Myocardial Infarction; Myocardium; Platelet Endothelial Cell Adhesion Molecule-1; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; STAT3 Transcription Factor; Triterpenes; Weight Gain | 2019 |
Protective effect of Astragaloside IV to inhibit thiram-induced tibial dyschondroplasia.
Topics: Animal Feed; Animals; Antioxidants; Chickens; Cyclooxygenase 2; Enzymes; Gene Expression; Liver; Osteochondrodysplasias; Poultry Diseases; Protective Agents; Saponins; Thiram; Tibia; Triterpenes | 2019 |
Astragaloside IV and ferulic acid synergistically promote neurite outgrowth through Nrf2 activation.
Topics: Animals; Coumaric Acids; Glycogen Synthase Kinase 3 beta; MAP Kinase Signaling System; Neurites; Neurotoxicity Syndromes; NF-E2-Related Factor 2; PC12 Cells; Rats; Saponins; Triterpenes | 2019 |
[Short-term water changes response of saponin biosynthesis process in Astragalus membranceus].
Topics: Astragalus Plant; Chromatography, High Pressure Liquid; Droughts; Saponins; Stress, Physiological; Triterpenes; Water | 2019 |
Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway.
Topics: Angiogenesis Inducing Agents; Animals; Apoptosis; Cardiotonic Agents; Cell Line, Tumor; Cell Proliferation; Human Umbilical Vein Endothelial Cells; Humans; Male; Myocardial Infarction; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Triterpenes; Vascular Endothelial Growth Factor A | 2019 |
Effects of astragaloside IV on inflammation and immunity in rats with experimental periodontitis.
Topics: Animals; Female; Immune System; Immunoglobulins; Interleukin-1beta; Interleukin-2; Male; Periodontitis; Random Allocation; Rats, Wistar; Reference Values; Reproducibility of Results; Saponins; T-Lymphocyte Subsets; Tooth Mobility; Treatment Outcome; Triterpenes; Tumor Necrosis Factor-alpha | 2019 |
RETRACTED: Astragaloside IV protects cardiomyocytes from hypoxia-induced injury by down-regulation of lncRNA GAS5.
Topics: Animals; Cardiotonic Agents; Cell Line; Down-Regulation; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Rats; RNA, Long Noncoding; Saponins; TOR Serine-Threonine Kinases; Triterpenes | 2019 |
The effect of astragaloside IV on JAK2-STAT6 signalling pathway in mouse model of ovalbumin-induced asthma.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Female; Gene Expression Regulation; Janus Kinase 2; Leukocytes; Male; Methacholine Chloride; Mice; Mice, Inbred BALB C; Ovalbumin; Parasympathomimetics; Saponins; Signal Transduction; STAT6 Transcription Factor; Triterpenes | 2019 |
[Astragaloside IV attenuates cerebral ischemia and reperfusion injury and reduces activation of NLRP3 inflammasome and NF-κB phosphorylation in rats following a transient middle cerebral artery occlusion].
Topics: Animals; Brain Ischemia; Infarction, Middle Cerebral Artery; Inflammasomes; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphorylation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins; Triterpenes | 2019 |
Nutritional preconditioning induced by astragaloside Ⅳ on isolated hearts and cardiomyocytes against myocardial ischemia injury via improving Bcl-2-mediated mitochondrial function.
Topics: Animals; Antioxidants; Apoptosis; Biphenyl Compounds; Caspase 3; Cell Line; Cell Survival; Cytochromes c; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Nitrophenols; Piperazines; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Sulfonamides; Superoxide Dismutase; Triterpenes | 2019 |
Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress.
Topics: Animals; Body Weight; Cardiomyopathies; Cardiotoxicity; Cell Size; Doxorubicin; Gene Expression Regulation; Male; Mice; Myocytes, Cardiac; NADPH Oxidase 2; NADPH Oxidase 4; Organ Size; Oxidative Stress; Rats; Saponins; Triterpenes | 2019 |
Astragaloside IV reduces cardiomyocyte apoptosis in a murine model of coxsackievirus B3-induced viral myocarditis.
Topics: Animals; Apoptosis; Astragalus propinquus; Coxsackievirus Infections; Disease Models, Animal; Enterovirus B, Human; Male; Mice; Mice, Inbred C57BL; Myocarditis; Myocytes, Cardiac; Protective Agents; Random Allocation; Saponins; Triterpenes | 2019 |
Astragaloside IV Exerts a Myocardial Protective Effect against Cardiac Hypertrophy in Rats, Partially via Activating the Nrf2/HO-1 Signaling Pathway.
Topics: Animals; Cardiomegaly; Cell Line; Cell Survival; Heme Oxygenase-1; NF-E2-Related Factor 2; Rats; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes | 2019 |
Astragaloside IV attenuates inflammatory injury and promotes odontoblastic differentiation in lipopolysaccharide-stimulated MDPC-23 cells and rat pulpitis.
Topics: Animals; Cell Differentiation; Cell Line; Lipopolysaccharides; Male; Mice; Pulpitis; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Triterpenes | 2019 |
Astragaloside IV protects against hyperglycemia-induced vascular endothelial dysfunction by inhibiting oxidative stress and Calpain-1 activation.
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Biomarkers; Calpain; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Dipeptides; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Hyperglycemia; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Saponins; Streptozocin; Triterpenes; Vasodilation | 2019 |
[Astragaloside Ⅳ regulates Nrf2/Bach1/HO-1 signaling pathway and inhibits H9c2 cardiomyocyte injury induced by hypoxia-reoxygenation].
Topics: Apoptosis; Basic-Leucine Zipper Transcription Factors; Cell Hypoxia; Cells, Cultured; Heme Oxygenase-1; Humans; Myocytes, Cardiac; NF-E2-Related Factor 2; Saponins; Signal Transduction; Triterpenes | 2019 |
[Optimization of determination methods of astragaloside Ⅳ and analysis of contents of astragaloside Ⅳ in different origin and grade].
Topics: Astragalus Plant; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Saponins; Triterpenes | 2019 |
Astragaloside IV ameliorates motor deficits and dopaminergic neuron degeneration via inhibiting neuroinflammation and oxidative stress in a Parkinson's disease mouse model.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Inflammasomes; Lipopolysaccharides; Male; Mice, Inbred C57BL; Microglia; Motor Activity; MPTP Poisoning; Neuroprotective Agents; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Rats; Saponins; Triterpenes | 2019 |
Protective Effect of Astragaloside IV on Hepatic Injury Induced by Iron Overload.
Topics: Autophagosomes; bcl-2-Associated X Protein; Cell Line; Cell Survival; Hepatocytes; Humans; Iron Overload; Iron-Dextran Complex; Liver; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-bcl-2; RNA-Binding Proteins; Saponins; Triterpenes | 2019 |
Astragaloside IV protects endothelial progenitor cells from the damage of ox-LDL via the LOX-1/NLRP3 inflammasome pathway.
Topics: Animals; Cell Line; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Endothelial Progenitor Cells; Inflammasomes; Lipoproteins, LDL; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Rats; Saponins; Scavenger Receptors, Class E; Structure-Activity Relationship; Triterpenes | 2019 |
Effect of astragaloside IV and the role of nuclear receptor RXRα in human peritoneal mesothelial cells in high glucose‑based peritoneal dialysis fluids.
Topics: Cell Line; Cell Survival; Dialysis Solutions; Epithelial Cells; Epithelial-Mesenchymal Transition; Glucose; Humans; Peritoneal Dialysis; Peritoneum; Retinoid X Receptor alpha; Saponins; Triterpenes | 2019 |
Inhibitory effects of astragaloside IV on silica-induced pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling.
Topics: Actins; Animals; Collagen Type I; Collagen Type III; Down-Regulation; Fibroblasts; Lung; Phosphorylation; Pulmonary Fibrosis; Rats, Sprague-Dawley; Rats, Wistar; RNA, Messenger; Saponins; Signal Transduction; Silicon Dioxide; Silicosis; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1; Triterpenes | 2019 |
Astragaloside IV alleviates myocardial ischemia-reperfusion injury in rats through regulating PI3K/AKT/GSK-3β signaling pathways.
Topics: Animals; Glycogen Synthase Kinase 3 beta; Male; Myocardial Reperfusion Injury; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Triterpenes | 2019 |
Astragaloside IV Alleviates the Myocardial Damage Induced by Lipopolysaccharide via the Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB)/Proliferator-Activated Receptor α (PPARα) Signaling Pathway.
Topics: Animals; Cell Survival; China; Heart; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; NF-kappa B; PPAR alpha; Saponins; Signal Transduction; Toll-Like Receptor 4; Triterpenes; Tumor Necrosis Factor-alpha | 2019 |
Astragaloside IV Attenuates Lipopolysaccharides-Induced Pulmonary Epithelial Cell Injury through Inhibiting Autophagy.
Topics: Animals; Anti-Inflammatory Agents; Autophagy; Cell Line; Cell Survival; Epithelial Cells; Lipopolysaccharides; Lung Injury; Mice; Oxidative Stress; Respiratory Distress Syndrome; Respiratory Mucosa; Saponins; Triterpenes | 2020 |
Astragaloside IV protects neurons from microglia-mediated cell damage through promoting microglia polarization.
Topics: Animals; Cell Death; Cell Polarity; Cytokines; Lipopolysaccharides; Microglia; Neurons; Neuroprotective Agents; PC12 Cells; Rats; Saponins; Signal Transduction; Triterpenes | 2019 |
Astragaloside IV attenuates gestational diabetes mellitus via targeting NLRP3 inflammasome in genetic mice.
Topics: Animals; Blood Glucose; Diabetes, Gestational; Female; Gene Expression Regulation; Inflammasomes; Insulin; Interleukin-6; Mice, Inbred C57BL; Molecular Structure; NLR Family, Pyrin Domain-Containing 3 Protein; Pregnancy; Saponins; Triterpenes; Tumor Necrosis Factor-alpha | 2019 |
Astragaloside IV alleviates ischemia reperfusion-induced apoptosis by inhibiting the activation of key factors in death receptor pathway and mitochondrial pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Brain Infarction; Disease Models, Animal; Male; Mitochondria; Neuroprotective Agents; Rats, Sprague-Dawley; Receptors, Death Domain; Reperfusion Injury; Saponins; Signal Transduction; Triterpenes | 2020 |
Dual regulation of microglia and neurons by Astragaloside IV-mediated mTORC1 suppression promotes functional recovery after acute spinal cord injury.
Topics: Animals; Apoptosis; Autophagy; Cell Polarity; Cells, Cultured; Disease Models, Animal; Female; Inflammation; Macrophages; Mechanistic Target of Rapamycin Complex 1; Microglia; Neurons; Rats; Rats, Sprague-Dawley; Recovery of Function; Saponins; Signal Transduction; Spinal Cord Injuries; Triterpenes | 2020 |
Astragaloside IV alleviates myocardial damage induced by type 2 diabetes via improving energy metabolism.
Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Energy Metabolism; Male; Muscle Proteins; Myocardium; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2019 |
Astragaloside-IV protects H9C2(2-1) cardiomyocytes from high glucose-induced injury via miR-34a-mediated autophagy pathway.
Topics: Animals; Autophagy; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Glucose; MicroRNAs; Myocytes, Cardiac; Oxidative Stress; Rats; Saponins; Triterpenes | 2019 |
Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathway.
Topics: Animals; Animals, Newborn; Astragalus Plant; Cardiomyopathy, Hypertrophic; Cells, Cultured; Disease Models, Animal; Fibrosis; Humans; Isoproterenol; Male; Medicine, Chinese Traditional; MicroRNAs; Myocardium; Myofibroblasts; Plant Extracts; Plant Roots; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Triterpenes; TRPM Cation Channels | 2020 |
Astragaloside IV protects against diabetic nephropathy via activating eNOS in streptozotocin diabetes-induced rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Protective Agents; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Triterpenes | 2019 |
Astragaloside IV Protects Against Oxidative Stress in Calf Small Intestine Epithelial Cells via NFE2L2-Antioxidant Response Element Signaling.
Topics: Animals; Antioxidant Response Elements; Cattle; Epithelial Cells; Hydrogen Peroxide; Intestine, Small; NF-E2-Related Factor 2; Oxidative Stress; Saponins; Signal Transduction; Triterpenes | 2019 |
Astragaloside IV reverses simvastatin-induced skeletal muscle injury by activating the AMPK-PGC-1α signalling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Male; Mice; Muscle, Skeletal; Saponins; Signal Transduction; Simvastatin; Triterpenes | 2020 |
Astragaloside IV Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the Janus Kinase 2 and Signal Transducer and Activator of Transcription 3 Signaling Pathway.
Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Janus Kinase 2; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Saponins; Signal Transduction; STAT3 Transcription Factor; Superoxide Dismutase; Triterpenes | 2020 |
Astragaloside IV attenuates sepsis-induced intestinal barrier dysfunction via suppressing RhoA/NLRP3 inflammasome signaling.
Topics: ADP Ribose Transferases; Animals; Astragalus propinquus; Botulinum Toxins; Caco-2 Cells; Disease Models, Animal; Drugs, Chinese Herbal; Gene Knockdown Techniques; Humans; Inflammasomes; Injections, Intravenous; Intestinal Mucosa; Male; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Permeability; rhoA GTP-Binding Protein; RNA, Small Interfering; Saponins; Sepsis; Signal Transduction; Triterpenes | 2020 |
Astragaloside IV Synergizes with Ferulic Acid to Alleviate Hepatic Fibrosis in Bile Duct-Ligated Cirrhotic Rats.
Topics: Animals; Cholestasis; Common Bile Duct; Coumaric Acids; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Hepatic Stellate Cells; Ligation; Liver; Liver Cirrhosis, Biliary; Male; NF-E2-Related Factor 2; Oxidative Stress; Rats, Wistar; Receptors, Transforming Growth Factor beta; Saponins; Signal Transduction; Smad3 Protein; Smad4 Protein; Transforming Growth Factor beta1; Triterpenes | 2020 |
Discovery of chemical markers for identifying species, growth mode and production area of Astragali Radix by using ultra-high-performance liquid chromatography coupled to triple quadrupole mass spectrometry.
Topics: Astragalus propinquus; China; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Germany; Principal Component Analysis; Quality Control; Reproducibility of Results; Republic of Korea; Saponins; Tandem Mass Spectrometry; Triterpenes | 2020 |
Astragaloside IV ameliorates intermittent hypoxia-induced inflammatory dysfunction by suppressing MAPK/NF-κB signalling pathways in Beas-2B cells.
Topics: Cells, Cultured; Humans; Hypoxia; Inflammation; Lung; MAP Kinase Signaling System; NF-kappaB-Inducing Kinase; Protein Serine-Threonine Kinases; Respiratory Mucosa; Saponins; Sleep Apnea, Obstructive; Triterpenes | 2020 |
A new strategy for the preparation of antibody against natural glycoside: With astragaloside IV as an example.
Topics: Animals; Antibodies; Antibody Specificity; Antigens; Male; Molecular Structure; Rabbits; Saponins; Triterpenes | 2020 |
Astragaloside IV suppresses inflammatory response via suppression of NF-κB, and MAPK signalling in human bronchial epithelial cells.
Topics: Cell Line; Epithelial Cells; Humans; MAP Kinase Signaling System; NF-E2-Related Factor 2; NF-kappa B; Saponins; Triterpenes; Tumor Necrosis Factor-alpha | 2022 |
Early astragaloside IV administration attenuates experimental autoimmune encephalomyelitis in mice by suppressing the maturation and function of dendritic cells.
Topics: Animals; Coculture Techniques; Cytokines; Dendritic Cells; Encephalomyelitis, Autoimmune, Experimental; Female; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; NF-kappa B; Saponins; Severity of Illness Index; Triterpenes | 2020 |
Astragaloside IV attenuates IL-1β secretion by enhancing autophagy in H1N1 infection.
Topics: A549 Cells; Autophagosomes; Autophagy; Chloroquine; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Interleukin-1beta; Lysosomes; Saponins; Triterpenes | 2020 |
Astragalus polysaccharides and astragaloside IV ameliorates cyclophosphamide-induced mouse model of overactive bladder.
Topics: Animals; Astragalus Plant; Cell Movement; Cell Proliferation; Cyclophosphamide; Disease Models, Animal; Female; Fibroblasts; Humans; Mice; Polysaccharides; Saponins; Triterpenes; Urinary Bladder, Overactive; Urination; Urothelium | 2020 |
Astragaloside IV suppresses transforming growth factor-β1-induced epithelial-mesenchymal transition through inhibition of Wnt/β-catenin pathway in glioma U251 cells.
Topics: Antigens, CD; Apoptosis; beta Catenin; Brain Neoplasms; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Glioma; Humans; Saponins; Transforming Growth Factor beta1; Triterpenes; Wnt Signaling Pathway | 2020 |
Metastasis-associated protein 1 promotes epithelial-mesenchymal transition in idiopathic pulmonary fibrosis by up-regulating Snail expression.
Topics: Animals; Bleomycin; Epithelial-Mesenchymal Transition; Idiopathic Pulmonary Fibrosis; Proteins; Rats; Saponins; Signal Transduction; Smad3 Protein; Snail Family Transcription Factors; Transforming Growth Factor beta1; Triterpenes; Up-Regulation | 2020 |
The chemical transformations for Radix Astragali via different alkaline wash conditions by quantitative and qualitative analyses.
Topics: Alkalies; Astragalus Plant; Astragalus propinquus; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Hydrolysis; Quality Control; Saponins; Tandem Mass Spectrometry; Technology, Pharmaceutical; Triterpenes | 2020 |
Protective effects of AS-IV on diabetic cardiomyopathy by improving myocardial lipid metabolism in rat models of T2DM.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Diet, High-Fat; Fibrosis; Inflammation; Lipid Metabolism; Male; Myocardium; Rats; Saponins; Triterpenes | 2020 |
Astragaloside IV inhibits astrocyte senescence: implication in Parkinson's disease.
Topics: Animals; Astrocytes; Cellular Senescence; Dopaminergic Neurons; Male; Mice; Nerve Degeneration; Neuroprotective Agents; Parkinsonian Disorders; Saponins; Triterpenes | 2020 |
Astragaloside IV enhances cisplatin chemosensitivity in hepatocellular carcinoma by suppressing MRP2.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Interactions; Drug Resistance, Neoplasm; Hep G2 Cells; Humans; Kidney; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Saponins; Triterpenes | 2020 |
Quantitative proteomics analysis of differentially expressed proteins induced by astragaloside IV in cervical cancer cell invasion.
Topics: Animals; Autophagy; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drugs, Chinese Herbal; Endoribonucleases; Female; Gene Ontology; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Protein Interaction Maps; Proteome; Proteomics; Saponins; Signal Transduction; Thymosin; Trans-Activators; Triterpenes; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2020 |
Astragaloside IV enhances GATA-4 mediated myocardial protection effect in hypoxia/reoxygenation injured H9c2 cells.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Proteins; Cell Hypoxia; Cell Line; Cytoprotection; GATA4 Transcription Factor; Myocardial Reperfusion Injury; Myocytes, Cardiac; Rats; Saponins; Signal Transduction; Triterpenes; Up-Regulation | 2020 |
Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Ca
Topics: Animals; Apoptosis; Calcium; Echocardiography; Fibrosis; Heart; Homeostasis; Hypoxia; Male; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Saponins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sleep Apnea, Obstructive; Triterpenes | 2020 |
Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Caco-2 Cells; Computational Biology; Diabetic Nephropathies; Disease Models, Animal; Epithelial-Mesenchymal Transition; Gene Regulatory Networks; Humans; Inflammation Mediators; Kidney; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Oxidative Stress; Protein Interaction Maps; Rats, Sprague-Dawley; Saponins; Triterpenes; Wnt Signaling Pathway | 2020 |
Astragaloside IV protects human cardiomyocytes from hypoxia/reoxygenation injury by regulating miR-101a.
Topics: Apoptosis; Cell Hypoxia; Cell Proliferation; Cell Survival; Computational Biology; Gene Expression Profiling; Humans; Inflammation; L-Lactate Dehydrogenase; Malondialdehyde; MAP Kinase Signaling System; MicroRNAs; Myocardial Reperfusion Injury; Myocytes, Cardiac; Receptor, Transforming Growth Factor-beta Type I; Regeneration; Saponins; Signal Transduction; Superoxide Dismutase; Toll-Like Receptor 2; Triterpenes | 2020 |
Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism.
Topics: Animals; Antioxidants; Brain; Cell Cycle Proteins; Cell Proliferation; Cellular Senescence; G1 Phase Cell Cycle Checkpoints; Male; Mice; Neurons; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species; Saponins; Triterpenes | 2020 |
Effect of astragaloside IV on cognitive dysfunction in rats with cerebrally infarcted via TGF-β / Smad signaling pathway.
Topics: Animals; Case-Control Studies; Cerebral Infarction; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Male; Rats; Rats, Sprague-Dawley; Saponins; Severity of Illness Index; Signal Transduction; Smad Proteins; Smad1 Protein; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta; Triterpenes | 2020 |
Astragaloside IV suppresses development of hepatocellular carcinoma by regulating miR-150-5p/β-catenin axis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Saponins; Triterpenes | 2020 |
Astragaloside IV regulates the HIF/VEGF/Notch signaling pathway through miRNA-210 to promote angiogenesis after ischemic stroke.
Topics: Adult; Animals; Disease Models, Animal; Endothelial Cells; Humans; Hypoxia-Inducible Factor 1; Ischemic Stroke; Male; MicroRNAs; Neovascularization, Pathologic; Rats; Rats, Sprague-Dawley; Receptors, Notch; Saponins; Signal Transduction; Triterpenes; Vascular Endothelial Growth Factor A | 2020 |
Astragaloside-IV regulates endoplasmic reticulum stress-mediated neuronal apoptosis in a murine model of Parkinson's disease via the lincRNA-p21/CHOP pathway.
Topics: Animals; Apoptosis; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Endoplasmic Reticulum Stress; Male; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Parkinson Disease; Protein Stability; RNA, Long Noncoding; Saponins; Signal Transduction; Transcription Factor CHOP; Triterpenes | 2020 |
Astragaloside IV attenuates high glucose-induced EMT by inhibiting the TGF-β/Smad pathway in renal proximal tubular epithelial cells.
Topics: Animals; Apoptosis; Cadherins; Cell Line; Diabetic Nephropathies; Epithelial Cells; Epithelial-Mesenchymal Transition; Glucose; Kidney Tubules, Proximal; Nerve Tissue Proteins; Occludin; Phosphorylation; Rats; Saponins; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1; Triterpenes; Vimentin | 2020 |
Ultra-small-size Astragaloside-IV loaded lipid nanocapsules eye drops for the effective management of dry age-related macular degeneration.
Topics: Animals; Apoptosis; Macular Degeneration; Male; Mice; Mice, Inbred C57BL; Nanocapsules; Ophthalmic Solutions; Phospholipids; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Retinal Pigment Epithelium; Saponins; Triterpenes | 2020 |
Astragaloside IV alleviates the brain damage induced by subarachnoid hemorrhage via PI3K/Akt signaling pathway.
Topics: Animals; Brain Edema; Brain Injuries; Dose-Response Relationship, Drug; Male; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Subarachnoid Hemorrhage; Triterpenes | 2020 |
Astragaloside IV as Potential Antioxidant Against Diabetic Ketoacidosis in Juvenile Mice Through Activating JNK/Nrf2 Signaling Pathway.
Topics: Animals; Antioxidants; Child; Child, Preschool; Diabetic Ketoacidosis; Disease Models, Animal; Drugs, Chinese Herbal; Female; Humans; Male; MAP Kinase Signaling System; Mice; NF-E2-Related Factor 2; Saponins; Signal Transduction; Triterpenes | 2020 |
Astragaloside IV protects retinal pigment epithelial cells from apoptosis by upregulating miR‑128 expression in diabetic rats.
Topics: Animals; Apoptosis; Astragalus Plant; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Diabetes Mellitus, Experimental; Fas Ligand Protein; Female; Flow Cytometry; In Situ Nick-End Labeling; Male; MicroRNAs; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Saponins; Triterpenes | 2020 |
Astragaloside IV alleviates mouse slow transit constipation by modulating gut microbiota profile and promoting butyric acid generation.
Topics: Animals; Antidiarrheals; Butyric Acid; Constipation; Feces; Female; Gastrointestinal Microbiome; Loperamide; Male; Mice; Saponins; Triterpenes | 2020 |
Astragaloside IV improves neurobehavior and promotes hippocampal neurogenesis in MCAO rats though BDNF-TrkB signaling pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Hippocampus; Infarction, Middle Cerebral Artery; Male; Neurogenesis; Neuroprotective Agents; Rats, Sprague-Dawley; Receptor, trkB; Saponins; Signal Transduction; Stroke; Triterpenes | 2020 |
Astragaloside IV Promotes Antiphotoaging by Enhancing the Proliferation and Paracrine Activity of Adipose-Derived Stem Cells.
Topics: Adipose Tissue; Adult; Animals; Cell Differentiation; Cell Proliferation; Collagen Type I; Culture Media, Conditioned; Dermis; Disease Models, Animal; Down-Regulation; Female; Fibroblasts; Humans; Intercellular Signaling Peptides and Proteins; Light; Matrix Metalloproteinase 1; Mice, Inbred BALB C; Microvessels; Paracrine Communication; Phenotype; Saponins; Skin Aging; Stem Cells; Triterpenes; Ultraviolet Rays; Up-Regulation; Young Adult | 2020 |
Ecological niche modeling of Astragalus membranaceus var. mongholicus medicinal plants in Inner Mongolia, China.
Topics: Astragalus propinquus; China; Drugs, Chinese Herbal; Ecosystem; Glucosides; Plants, Medicinal; Saponins; Seasons; Triterpenes | 2020 |
Protective role of Astragaloside IV in chronic glomerulonephritis by activating autophagy through PI3K/AKT/AS160 pathway.
Topics: Animals; Astragalus propinquus; Autophagy; Cells, Cultured; Cytoprotection; Glomerulonephritis; GTPase-Activating Proteins; Humans; Kidney; Male; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Saponins; Signal Transduction; Triterpenes | 2020 |
Astragaloside IV prevents Aβ
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Hippocampus; Maze Learning; Memory Disorders; Mice; Neurons; Neuroprotective Agents; PPAR gamma; Saponins; Signal Transduction; Triterpenes | 2020 |
Astragaloside IV Extends Lifespan of
Topics: Animals; Antioxidants; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Longevity; Oxidative Stress; Saponins; Triterpenes | 2021 |
Astragaloside IV enhanced carboplatin sensitivity in prostate cancer by suppressing AKT/NF-κB signaling pathway.
Topics: Animals; Antineoplastic Agents; Carboplatin; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Male; Mice; Mice, Nude; Neoplasms, Experimental; NF-kappa B; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Saponins; Triterpenes; Tumor Cells, Cultured | 2021 |
Positive effect of Astragaloside IV on neurite outgrowth via talin-dependent integrin signaling and microfilament force.
Topics: Actin Cytoskeleton; Actins; Animals; Biomechanical Phenomena; Cell Line, Tumor; Cerebral Cortex; Humans; Integrins; Mice, Inbred C57BL; Models, Biological; Neuronal Outgrowth; Neurons; Saponins; Signal Transduction; Talin; Triterpenes; Up-Regulation | 2021 |
Transcriptomic Analysis Reveals the Protection of Astragaloside IV against Diabetic Nephropathy by Modulating Inflammation.
Topics: Animals; Collagen Type IV; Cytokines; Diabetic Nephropathies; Fibronectins; Fibrosis; Gene Expression Profiling; Glycation End Products, Advanced; Inflammation; Inflammation Mediators; Male; NLR Proteins; Podocytes; Protective Agents; Rats, Sprague-Dawley; Saponins; Signal Transduction; Transcription, Genetic; Triterpenes | 2020 |
Astragaloside IV, a saponin from Astragalus membranaceus var. mongholicus, induces expressions of heme recycle proteins via signaling of Nrf2/ARE in cultured macrophages.
Topics: Animals; Antioxidant Response Elements; Astragalus propinquus; Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Heme; Heme Oxygenase-1; Macrophages; Medicine, Chinese Traditional; Mice; NF-E2-Related Factor 2; RAW 264.7 Cells; Saponins; Signal Transduction; Triterpenes | 2021 |
Astragaloside IV ameliorates preeclampsia-induced oxidative stress through the Nrf2/HO-1 pathway in a rat model.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Glutathione; Glutathione Peroxidase; Heme Oxygenase (Decyclizing); Malondialdehyde; NF-E2-Related Factor 2; Oxidative Stress; Placenta; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Rats; Rats, Wistar; Saponins; Signal Transduction; Triterpenes; Vascular Endothelial Growth Factor Receptor-1 | 2020 |
Quantification by LC-MS/MS of astragaloside IV and isoflavones in Astragali radix can be more accurate by using standard addition.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Drugs, Chinese Herbal; Isoflavones; Reproducibility of Results; Saponins; Tandem Mass Spectrometry; Triterpenes | 2021 |
Astragaloside IV-induced Nrf2 nuclear translocation ameliorates lead-related cognitive impairments in mice.
Topics: Animals; Antioxidants; Cognitive Dysfunction; Glycogen Synthase Kinase 3 beta; Heme Oxygenase-1; Membrane Proteins; Mice; NF-E2-Related Factor 2; Organometallic Compounds; Oxidative Stress; PC12 Cells; Phosphorylation; Rats; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes | 2021 |
Astragaloside IV alleviates lipopolysaccharide-induced preeclampsia-like phenotypes via suppressing the inflammatory responses.
Topics: Animals; Blood Pressure; Cytokines; Disease Models, Animal; Female; Heart Rate; Inflammation; Lipopolysaccharides; NF-kappa B; Phenotype; Placenta; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Proteinuria; Rats, Sprague-Dawley; RNA, Messenger; Saponins; Toll-Like Receptor 4; Triterpenes; Urine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2021 |
Astragaloside IV Exerts Anti-tumor Effect on Murine Colorectal Cancer by Re-educating Tumor-Associated Macrophage.
Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Line, Tumor; Colorectal Neoplasms; Cytokines; Drug Therapy, Combination; Female; Humans; Immune Checkpoint Inhibitors; Mice; Mice, Inbred BALB C; Programmed Cell Death 1 Receptor; Saponins; Th1 Cells; Th2 Cells; Triterpenes; Tumor Microenvironment; Tumor-Associated Macrophages | 2020 |
Antiviral activity of astragaloside II, astragaloside III and astragaloside IV compounds against dengue virus: Computational docking and in vitro studies.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Dengue; Dengue Virus; Molecular Docking Simulation; Saponins; Triterpenes; Vero Cells; Viral Nonstructural Proteins | 2021 |
Altered metabolic profiles and biomarkers associated with astragaloside IV-mediated protection against cisplatin-induced acute kidney injury in rats: An HPLC-TOF/MS-based untargeted metabolomics study.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Biomarkers; Chromatography, High Pressure Liquid; Cisplatin; Male; Mass Spectrometry; Metabolome; Metabolomics; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2021 |
Astragaloside IV inhibits protein tyrosine phosphatase 1B and improves insulin resistance in insulin-resistant HepG2 cells and triglyceride accumulation in oleic acid (OA)-treated HepG2 cells.
Topics: Cell Survival; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Insulin Resistance; Oleic Acid; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Saponins; Triglycerides; Triterpenes | 2021 |
Astragaloside‑IV modulates NGF‑induced osteoblast differentiation via the GSK3β/β‑catenin signalling pathway.
Topics: Cell Differentiation; Cell Proliferation; Cells, Cultured; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Humans; Mesenchymal Stem Cells; Nerve Growth Factor; Osteogenesis; Osteoporosis; Saponins; Triterpenes; Wnt Signaling Pathway | 2021 |
Astragaloside IV inhibits cell proliferation and metastasis of breast cancer via promoting the long noncoding RNA TRHDE-AS1.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Male; Mice; Mice, Nude; Neoplasm Metastasis; RNA, Long Noncoding; Saponins; Transfection; Triterpenes | 2021 |
Astragaloside IV and echinacoside benefit neuronal properties via direct effects and through upregulation of SOD1 astrocyte function in vitro.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astragalus propinquus; Astrocytes; Cistanche; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glycosides; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Neurons; Saponins; Superoxide Dismutase-1; Triterpenes; Up-Regulation | 2021 |
The role of Nrf2 in astragaloside IV-mediated antioxidative protection on heart failure.
Topics: Animals; Antioxidants; Cardiotonic Agents; Cell Line; Echocardiography; Heart Failure; Heme Oxygenase-1; Male; Myocardial Infarction; Myocytes, Cardiac; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Stroke Volume; Survival Analysis; Transcriptional Activation; Triterpenes | 2020 |
Astragaloside IV protects against retinal iron overload toxicity through iron regulation and the inhibition of MAPKs and NF-κB activation.
Topics: Animals; Humans; Iron; Iron Overload; Male; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Retinal Pigment Epithelium; Saponins; Triterpenes | 2021 |
Astragaloside IV attenuates inflammatory response mediated by NLRP-3/calpain-1 is involved in the development of pulmonary hypertension.
Topics: Animals; Blotting, Western; Calpain; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Inflammation; Interleukin-18; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Rats, Sprague-Dawley; Saponins; Triterpenes | 2021 |
Astragaloside IV antagonizes M2 phenotype macrophage polarization-evoked ovarian cancer cell malignant progression by suppressing the HMGB1-TLR4 axis.
Topics: Cell Movement; Cell Polarity; Disease Progression; Female; HMGB1 Protein; Humans; Macrophage Activation; Macrophages; Ovarian Neoplasms; Phenotype; Saponins; Signal Transduction; THP-1 Cells; Toll-Like Receptor 4; Triterpenes; Tumor Cells, Cultured; Tumor Microenvironment | 2021 |
Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain: involvement of histone deacetylase inhibition.
Topics: Animals; Brain; Histone Deacetylases; Killer Cells, Natural; Rats; Saponins; Triterpenes | 2021 |
Astragaloside IV alleviates PM2.5-induced lung injury in rats by modulating TLR4/MyD88/NF-κB signalling pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Disease Models, Animal; Inflammation Mediators; Lung; Lung Injury; Male; Myeloid Differentiation Factor 88; NF-kappa B; Oxidative Stress; Particulate Matter; Pulmonary Edema; Rats, Sprague-Dawley; Saponins; Signal Transduction; Toll-Like Receptor 4; Triterpenes | 2021 |
Astragaloside IV attenuates cerebral ischemia‑reperfusion injury in rats through the inhibition of calcium‑sensing receptor‑mediated apoptosis.
Topics: Animals; Apoptosis; Cerebrovascular Disorders; Disease Models, Animal; Male; Rats; Rats, Sprague-Dawley; Receptors, Calcium-Sensing; Reperfusion Injury; Saponins; Triterpenes | 2021 |
Astragaloside IV blocks monocrotaline‑induced pulmonary arterial hypertension by improving inflammation and pulmonary artery remodeling.
Topics: Animals; Hypertension, Pulmonary; Inflammation; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes; Vascular Remodeling | 2021 |
Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPARγ pathway after cerebral ischemia/reperfusion injury in rats.
Topics: Animals; Brain Injuries; Cell Polarity; Disease Models, Animal; Infarction, Middle Cerebral Artery; Macrophages; Male; Microglia; Neovascularization, Physiologic; Neurogenesis; PPAR gamma; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins; Triterpenes | 2021 |
Beneficial Effects of Astragaloside IV-Treated and 3-Dimensional-Cultured Endothelial Progenitor Cells on Angiogenesis and Wound Healing.
Topics: Animals; Endothelial Progenitor Cells; Mice; Mice, Nude; Neovascularization, Physiologic; Saponins; Triterpenes; Wound Healing | 2021 |
Astragaloside IV alleviates atherosclerosis through targeting circ_0000231/miR-135a-5p/CLIC4 axis in AS cell model in vitro.
Topics: Atherosclerosis; Chloride Channels; Human Umbilical Vein Endothelial Cells; Humans; MicroRNAs; Models, Cardiovascular; RNA, Circular; Saponins; Triterpenes | 2021 |
Astragaloside IV protects against iron loading-induced abnormal differentiation of bone marrow mesenchymal stem cells (BMSCs).
Topics: Adipogenesis; Animals; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cell Survival; Disease Models, Animal; Female; Homeostasis; Iron; Mesenchymal Stem Cells; Mice; Osteogenesis; Osteoporosis; Saponins; Triterpenes; X-Ray Microtomography | 2021 |
Astragaloside IV alleviates silica‑induced pulmonary fibrosis via inactivation of the TGF‑β1/Smad2/3 signaling pathway.
Topics: Animals; Male; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Silicon Dioxide; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1; Triterpenes | 2021 |
Astragaloside IV Improves Tibial Defect in Rats and Promotes Proliferation and Osteogenic Differentiation of hBMSCs through MiR-124-3p.1/STAT3 Axis.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Female; Humans; Mesenchymal Stem Cells; MicroRNAs; Osteogenesis; Rats; Rats, Inbred Lew; Saponins; STAT3 Transcription Factor; Tibia; Triterpenes | 2021 |
Network Pharmacology and Experimental Evidence Identify the Mechanism of Astragaloside IV in Oxaliplatin Neurotoxicity.
Topics: Animals; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Male; Neurotoxicity Syndromes; Oxaliplatin; Oxidative Stress; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2021 |
Astragaloside IV protects against podocyte apoptosis by inhibiting oxidative stress via activating PPARγ-Klotho-FoxO1 axis in diabetic nephropathy.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Forkhead Box Protein O1; Gene Expression Regulation; Glucose; Glucuronidase; Klotho Proteins; Male; Mice; Mice, Inbred C57BL; Podocytes; PPAR gamma; Protective Agents; Saponins; Signal Transduction; Triterpenes | 2021 |
Neuroprotection Effect of Astragaloside IV from 2-DG-Induced Endoplasmic Reticulum Stress.
Topics: Adrenal Gland Neoplasms; Animals; Apoptosis; Cardiotonic Agents; Deoxyglucose; Endoplasmic Reticulum Stress; Glycogen Synthase Kinase 3 beta; Membrane Potential, Mitochondrial; Neuroprotective Agents; PC12 Cells; Pheochromocytoma; Phosphorylation; Rats; Saponins; Triterpenes | 2020 |
Astragaloside IV improves angiogenesis under hypoxic conditions by enhancing hypoxia‑inducible factor‑1α SUMOylation.
Topics: Cell Hypoxia; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neovascularization, Physiologic; Saponins; Sumoylation; Triterpenes | 2021 |
Induction of autophagy via the TLR4/NF-κB signaling pathway by astragaloside Ⅳ contributes to the amelioration of inflammation in RAW264.7 cells.
Topics: Animals; Anti-Inflammatory Agents; Autophagy; Cytokines; Inflammation; Macrophages; Mice; NF-kappa B; Phosphorylation; RAW 264.7 Cells; Saponins; Signal Transduction; Toll-Like Receptor 4; Triterpenes | 2021 |
Astragaloside IV ameliorates steroid-induced osteonecrosis of the femoral head by repolarizing the phenotype of pro-inflammatory macrophages.
Topics: Animals; Cells, Cultured; Female; Femur Head; Femur Head Necrosis; Glucocorticoids; Macrophages; Mice, Inbred C57BL; Phenotype; Saponins; Triterpenes | 2021 |
Astragaloside IV inhibits palmitic acid-induced apoptosis through regulation of calcium homeostasis in mice podocytes.
Topics: Animals; Apoptosis; Calcium; Endoplasmic Reticulum; Gene Expression Regulation; Homeostasis; Imidazoles; Membrane Potential, Mitochondrial; Mice; Mitochondria; Palmitic Acid; Podocytes; RNA, Small Interfering; Saponins; Triterpenes; TRPC6 Cation Channel | 2021 |
[Optimization of determination of astragaloside Ⅳ in Astragali Radix by continuous single-factor method].
Topics: Astragalus Plant; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Saponins; Triterpenes | 2021 |
Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling.
Topics: Animals; Doxorubicin; Ferroptosis; Gene Expression Regulation; Male; Muscle Proteins; Myocardium; NF-E2-Related Factor 2; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Triterpenes | 2021 |
Anti-anxiety and antidepressant-like effects of astragaloside IV and saponins extracted from Astragalus spinosus against the bisphenol A-induced motor and cognitive impairments in a postnatal rat model of schizophrenia.
Topics: Animals; Antidepressive Agents; Benzhydryl Compounds; Cognitive Dysfunction; Male; Phenols; Rats; Rats, Sprague-Dawley; Saponins; Schizophrenia; Triterpenes | 2021 |
Astragaloside IV Improves Angiogenesis and Promotes Wound Healing in Diabetic Rats
Topics: Animals; Cell Proliferation; Cells, Cultured; Cysteine Endopeptidases; Diabetes Mellitus, Experimental; Female; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; PPAR gamma; Proliferating Cell Nuclear Antigen; ras Proteins; Rats, Sprague-Dawley; Saponins; Signal Transduction; SUMO-1 Protein; Sumoylation; Triterpenes; Ubiquitin-Activating Enzymes; Ubiquitin-Conjugating Enzymes; Vascular Endothelial Growth Factor Receptor-2; Wound Healing | 2021 |
Treatment with astragaloside IV reduced blood glucose, regulated blood lipids, and protected liver function in diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Lipids; Liver; Oxidative Stress; Rats; Saponins; Triterpenes | 2021 |
Astragaloside IV-targeting miRNA-1 attenuates lipopolysaccharide-induced cardiac dysfunction in rats through inhibition of apoptosis and autophagy.
Topics: Animals; Apoptosis; Autophagy; Cardiotonic Agents; Echocardiography; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fluorescent Antibody Technique; Heart; Heart Diseases; Lipopolysaccharides; Male; MicroRNAs; Microscopy, Electron, Transmission; Myocardium; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2021 |
Astragalus Ⅳ ameliorates the dry eye injury in rabbit model via MUC1-ErbB1 pathway.
Topics: Animals; Benzalkonium Compounds; Cell Line; Conjunctiva; Cornea; Dry Eye Syndromes; ErbB Receptors; Female; Goblet Cells; Humans; Male; Mucin-1; Ophthalmic Solutions; Rabbits; Saponins; Signal Transduction; Tears; Triterpenes | 2021 |
[Astragaloside Ⅳ's Therapeutic Effect on Myocardial Infarction via Affecting Autophagy and the Mechanism Study].
Topics: Animals; Apoptosis; Autophagy; Myocardial Infarction; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Saponins; Signal Transduction; Triterpenes | 2021 |
Protective effects of Astragaloside IV against oxidative injury and apoptosis in cultured astrocytes by regulating Nrf2/JNK signaling.
Topics: Animals; Apoptosis; Astrocytes; Cells, Cultured; Kelch-Like ECH-Associated Protein 1; MAP Kinase Signaling System; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Oxygen; Rats; Reperfusion Injury; Saponins; Triterpenes | 2021 |
Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Astragalus propinquus; Autophagy; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucose; Homeostasis; Insulin Resistance; Liver; Male; Oxidative Stress; Quality of Life; Rats; Rats, Sprague-Dawley; Saponins; Streptozocin; TOR Serine-Threonine Kinases; Triterpenes | 2021 |
Extraction Optimization of Astragaloside IV by Response Surface Methodology and Evaluation of Its Stability during Sterilization and Storage.
Topics: Astragalus Plant; Astragalus propinquus; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Plant Roots; Plants, Medicinal; Protein Stability; Saponins; Sterilization; Surface Properties; Triterpenes | 2021 |
Astragaloside alleviates alcoholic fatty liver disease by suppressing oxidative stress.
Topics: Animals; Apoptosis; Cell Line; Disease Models, Animal; Fatty Liver, Alcoholic; Inflammation; Lipid Metabolism; Liver Function Tests; Male; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Saponins; Signal Transduction; Triterpenes | 2021 |
Accelerated Bone Regeneration by Astragaloside IV through Stimulating the Coupling of Osteogenesis and Angiogenesis.
Topics: Animals; Bone Marrow; Bone Regeneration; Cell Proliferation; Cells, Cultured; Drugs, Chinese Herbal; Male; Models, Animal; Neovascularization, Physiologic; Osteoblasts; Osteogenesis; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2021 |
Astragaloside regulates lncRNA LOC100912373 and the miR‑17‑5p/PDK1 axis to inhibit the proliferation of fibroblast‑like synoviocytes in rats with rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Cell Cycle; Cell Proliferation; Fibroblasts; Gene Expression Regulation; Male; MicroRNAs; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Rats, Sprague-Dawley; RNA, Long Noncoding; Saponins; Specific Pathogen-Free Organisms; Synoviocytes; Triterpenes | 2021 |
Astragaloside IV prevents acute myocardial infarction by inhibiting the TLR4/MyD88/NF-κB signaling pathway.
Topics: Animals; Molecular Docking Simulation; Myeloid Differentiation Factor 88; Myocardial Infarction; NF-kappa B; Rats; Rats, Sprague-Dawley; Saponins; Signal Transduction; Toll-Like Receptor 4; Triterpenes | 2021 |
Astragaloside IV Suppresses Hepatic Proliferation in Regenerating Rat Liver after 70% Partial Hepatectomy via Down-Regulation of Cell Cycle Pathway and DNA Replication.
Topics: Animals; Cell Cycle; Cell Proliferation; Cyclin D1; DNA Replication; Down-Regulation; Gene Expression Regulation; Gene Regulatory Networks; Hepatectomy; Hepatocyte Growth Factor; Liver; Liver Regeneration; Male; Molecular Sequence Annotation; Rats, Sprague-Dawley; RNA, Messenger; Saponins; Sequence Analysis, RNA; Transforming Growth Factor beta1; Triterpenes | 2021 |
Protective role of astragaloside IV in gastric cancer through regulation of microRNA-195-5p-mediated PD-L1.
Topics: B7-H1 Antigen; Cell Line, Tumor; Dose-Response Relationship, Drug; Epithelial-Mesenchymal Transition; Human Umbilical Vein Endothelial Cells; Humans; MicroRNAs; Saponins; Stomach Neoplasms; Triterpenes | 2021 |
Astragaloside IV Prevents Memory Impairment in D-galactose-induced Aging Rats Via the AGEs/RAGE/ NF-κB Axis.
Topics: Aging; Animals; Cytokines; Galactose; Glycation End Products, Advanced; Male; Memory Disorders; NF-kappa B; Oxidative Stress; Prospective Studies; Rats; Receptor for Advanced Glycation End Products; Saponins; Triterpenes | 2022 |
Suppression of plasmacytoid dendritic cell migration to colonic isolated lymphoid follicles abrogates the development of colitis.
Topics: Alkaloids; Animals; Cell Movement; Colitis; Colon; Dendritic Cells; Dextran Sulfate; Male; Mice; Mice, Inbred BALB C; Quinolizines; Saponins; Tertiary Lymphoid Structures; Triterpenes | 2021 |
Astragaloside IV ameliorates fat metabolism in the liver of ageing mice through targeting mitochondrial activity.
Topics: Aging; Animals; Fatty Acids; Lipid Metabolism; Liver; Mice; Mice, Inbred C57BL; Mitochondria; Saponins; Triterpenes | 2021 |
Astragaloside IV Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction in Rats via IKK/NF-κB Pathway.
Topics: Animals; Disease Models, Animal; Heart Diseases; NF-kappa B; Rats; Rats, Sprague-Dawley; Saponins; Sepsis; Triterpenes; Tumor Necrosis Factor-alpha | 2021 |
Astragaloside IV Ameliorates Cognitive Impairment and Neuroinflammation in an Oligomeric Aβ Induced Alzheimer's Disease Mouse Model via Inhibition of Microglial Activation and NADPH Oxidase Expression.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astragalus Plant; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Hippocampus; Male; Maze Learning; Mice, Inbred ICR; Microglia; NADP; NADPH Oxidases; Neuroinflammatory Diseases; Neurons; Neuroprotective Agents; Phytotherapy; Reactive Oxygen Species; Saponins; Triterpenes | 2021 |
Hypoglycemic effect of astragaloside IV via modulating gut microbiota and regulating AMPK/SIRT1 and PI3K/AKT pathway.
Topics: Adenylate Kinase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Dietary Sucrose; Gastrointestinal Microbiome; Gene Expression Regulation; Glucose; Hep G2 Cells; Humans; Hypoglycemic Agents; Insulin; Male; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Saponins; Sirtuin 1; Specific Pathogen-Free Organisms; Triterpenes | 2021 |
[Effect of intestinal flora changes on pharmacokinetics of astragaloside Ⅳ].
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Liquid; Diabetes Mellitus, Type 2; Gastrointestinal Microbiome; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Tandem Mass Spectrometry; Triterpenes | 2021 |
Astragaloside IV suppresses histamine-induced inflammatory factors and mucin 5 subtype AC overproduction in nasal epithelial cells via regulation of inflammation-related genes.
Topics: Cells, Cultured; Cytokines; Epithelial Cells; Histamine; Histamine Antagonists; Humans; Inflammation; Mucin 5AC; Nasal Mucosa; Rhinitis, Allergic; Saponins; Triterpenes | 2021 |
Astragaloside IV enhances the sensibility of lung adenocarcinoma cells to bevacizumab by inhibiting autophagy.
Topics: Adenocarcinoma of Lung; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Bevacizumab; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Proto-Oncogene Proteins c-akt; Saponins; TOR Serine-Threonine Kinases; Triterpenes | 2022 |
Astragaloside IV- and nesfatin-1-encapsulated phosphatidylserine liposomes conjugated with wheat germ agglutinin and leptin to activate anti-apoptotic pathway and block phosphorylated tau protein expression for Parkinson's disease treatment.
Topics: Dopaminergic Neurons; Humans; Leptin; Liposomes; Parkinson Disease; Phosphatidylserines; Saponins; tau Proteins; Triterpenes; Wheat Germ Agglutinins | 2021 |
Astragaloside IV alleviates Schwann cell injury in diabetic peripheral neuropathy by regulating microRNA-155-mediated autophagy.
Topics: Animals; Apoptosis; Autophagy; Diabetes Mellitus; Diabetic Neuropathies; MicroRNAs; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Saponins; Schwann Cells; Triterpenes | 2021 |
Depichering the Effects of Astragaloside IV on AD-Like Phenotypes: A Systematic and Experimental Investigation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astragalus propinquus; Computational Biology; Disease Models, Animal; Drugs, Chinese Herbal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Network Pharmacology; Neuroinflammatory Diseases; Peptide Fragments; Phenotype; Phosphorylation; Phytotherapy; PPAR gamma; Pyroptosis; Saponins; Signal Transduction; Support Vector Machine; tau Proteins; Triterpenes | 2021 |
Astragaloside IV attenuates hypoxia/reoxygenation injury-induced apoptosis of type II alveolar epithelial cells through miR-21-5p.
Topics: Alveolar Epithelial Cells; Animals; Apoptosis; Cell Hypoxia; Cell Line; MicroRNAs; Rats; Saponins; Triterpenes | 2021 |
Astragaloside IV alleviates heart failure by modulating Nrf-2.
Topics: Heart Failure; Humans; Saponins; Triterpenes | 2022 |
Borneol enhances the protective effect against cerebral ischemia/reperfusion injury by promoting the access of astragaloside IV and the components of Panax notoginseng saponins into the brain.
Topics: Animals; Brain; Brain Ischemia; Camphanes; Panax notoginseng; Rats; Reperfusion Injury; Saponins; Triterpenes | 2022 |
Evaluation of the effect of Shengxian Decoction on doxorubicin-induced chronic heart failure model rats and a multicomponent comparative pharmacokinetic study after oral administration in normal and model rats.
Topics: Animals; Astragalus propinquus; Cardiovascular Agents; Chromatography, High Pressure Liquid; Chronic Disease; Drugs, Chinese Herbal; Electrocardiography; Heart Failure; Male; Mass Spectrometry; Medicine, Chinese Traditional; Rats; Rats, Sprague-Dawley; Saponins; Triterpenes | 2021 |
Astragaloside IV Attenuates Ocular Hypertension in a Mouse Model of TGFβ2 Induced Primary Open Angle Glaucoma.
Topics: Animals; Aqueous Humor; Disease Models, Animal; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Mice; Ocular Hypertension; Saponins; Trabecular Meshwork; Transforming Growth Factor beta2; Triterpenes | 2021 |
Astragaloside IV Reduces OxLDL-Induced BNP Overexpression by Regulating HDAC.
Topics: Animals; Histone Deacetylases; Lipoproteins, LDL; Mice; Natriuretic Peptide, Brain; Quality of Life; Saponins; Triterpenes | 2021 |
Major Chemical Compounds and Mineral Elements of Astragalus membranaceus Cultivated on the Qinghai-Tibet Plateau with Different Planting Densities.
Topics: Astragalus propinquus; Biomass; Chromatography, High Pressure Liquid; Flavonoids; Minerals; Principal Component Analysis; Saponins; Tibet; Triterpenes | 2022 |
[Mechanism of astragaloside Ⅳ alleviating PC12 cell injury by activating PI3K/AKT signaling pathway: based on network pharmacology and in vitro experiments].
Topics: Animals; Drugs, Chinese Herbal; Molecular Docking Simulation; Network Pharmacology; PC12 Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Saponins; Signal Transduction; Triterpenes | 2021 |
Astragaloside IV pre-treatment attenuates PM2.5-induced lung injury in rats: Impact on autophagy, apoptosis and inflammation.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Inflammation; Lung Injury; Particulate Matter; Rats; Saponins; Triterpenes | 2022 |
Astragaloside IV promotes the angiogenic capacity of adipose-derived mesenchymal stem cells in a hindlimb ischemia model by FAK phosphorylation via CXCR2.
Topics: Adipose Tissue; Animals; Cell Proliferation; Chronic Limb-Threatening Ischemia; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Hindlimb; Human Umbilical Vein Endothelial Cells; Humans; Ischemia; Mesenchymal Stem Cells; Mice; Neovascularization, Physiologic; Phosphorylation; Receptors, Interleukin-8B; Saponins; Triterpenes | 2022 |
Astragaloside IV ameliorates peripheral immunosuppression induced by cerebral ischemia through inhibiting HPA axis.
Topics: Animals; Humans; Hypothalamo-Hypophyseal System; Immunosuppression Therapy; Infarction, Middle Cerebral Artery; Mice; Pituitary-Adrenal System; Saponins; Triterpenes | 2022 |
[Effects of astragaloside Ⅳ on inflammatory response and percentage of peripheral blood Th17 cells in mice with ulcerative colitis].
Topics: Animals; Colitis, Ulcerative; Mice; Saponins; T-Lymphocytes, Regulatory; Th17 Cells; Triterpenes | 2022 |
[Molecular mechanism of astragaloside Ⅳ against atherosclerosis by regulating miR-17-5p and PCSK9/VLDLR signal pathway].
Topics: Animals; Atherosclerosis; Lipoproteins, LDL; Mice; MicroRNAs; Proprotein Convertase 9; Receptors, LDL; Saponins; Signal Transduction; Triterpenes | 2022 |
Astragaloside IV-enhanced anti-hepatocarcinoma immunity of dendritic cells.
Topics: Carcinoma, Hepatocellular; Dendritic Cells; Humans; Liver Neoplasms; Saponins; Triterpenes | 2022 |
Astragaloside IV alleviates oxidative stress-related damage via inhibiting NLRP3 inflammasome in a MAPK signaling dependent pathway in human lens epithelial cells.
Topics: Cataract; Epithelial Cells; Humans; Inflammasomes; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Saponins; Triterpenes | 2022 |
The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy.
Topics: Animals; Benzoxazoles; Diabetic Nephropathies; Mice; Obesity; Saponins; Triazines; Triterpenes | 2022 |
Implication of IGF1R signaling in the protective effect of Astragaloside IV on ischemia and reperfusion-induced cardiac microvascular endothelial hyperpermeability.
Topics: Adenosine Triphosphate; Animals; Endothelial Cells; Endothelium; Ischemia; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Reperfusion; Saponins; Signal Transduction; Triterpenes | 2022 |
Astragaloside IV protects against C/EBP homologous protein-mediated apoptosis in oxidized low-density lipoprotein-treated macrophages by promoting autophagy.
Topics: Animals; Apoptosis; Autophagy; Beclin-1; Endoplasmic Reticulum Stress; Lipoproteins, LDL; Macrophages; Mice; Saponins; Signal Transduction; Sirolimus; Transcription Factor CHOP; Triterpenes | 2022 |
Implications for herbal polypharmacy: coumarin-induced hepatotoxicity increased through common herbal phytochemicals astragaloside IV and atractylenolide I.
Topics: Chemical and Drug Induced Liver Injury; Coumarins; Cytochrome P-450 Enzyme System; Herb-Drug Interactions; Humans; Lactones; Phytochemicals; Polypharmacy; Rifampin; Saponins; Sesquiterpenes; Triterpenes | 2022 |
Astragaloside IV exhibits anti-tumor function in gastric cancer via targeting circRNA dihydrolipoamide S-succinyltransferase (circDLST)/miR-489-3p/ eukaryotic translation initiation factor 4A1(EIF4A1) pathway.
Topics: Humans; MicroRNAs; Peptide Initiation Factors; RNA, Circular; Saponins; Stomach Neoplasms; Thioctic Acid; Triterpenes | 2022 |
Astragaloside IV alleviates PM2.5-caused lung toxicity by inhibiting inflammasome-mediated pyroptosis via NLRP3/caspase-1 axis inhibition in mice.
Topics: Animals; Caspase 1; Inflammasomes; Lung; Lung Diseases; Mice; Nigericin; NLR Family, Pyrin Domain-Containing 3 Protein; Particulate Matter; Pneumonia; Pyroptosis; Saponins; Signal Transduction; Triterpenes | 2022 |
Mitogen-activating protein kinase kinase kinase kinase-3, inhibited by Astragaloside IV through H3 lysine 4 monomethylation, promotes the progression of diabetic nephropathy by inducing apoptosis.
Topics: Animals; Apoptosis; Creatinine; Diabetes Mellitus; Diabetic Nephropathies; Female; Lysine; Male; Mice; Mitogens; Protein Kinases; Protein Serine-Threonine Kinases; Rats, Sprague-Dawley; Saponins; Triterpenes | 2022 |
Astragaloside IV drug-loaded exosomes (AS-IV EXOs) derived from endothelial progenitor cells improve the viability and tube formation in high-glucose impaired human endothelial cells by promoting miR-214 expression.
Topics: Cell Movement; Cell Proliferation; Endothelial Progenitor Cells; Exosomes; Glucose; Humans; MicroRNAs; Saponins; Triterpenes | 2022 |
Astragaloside IV improved antioxidative stress capacity and related gene expression of the Keap1-Nrf2 pathway in grass carp (Ctenopharyngodon idella) hepatocytes under heat stress.
Topics: Animal Feed; Animals; Carps; Copper; Diet; Fish Proteins; Gene Expression; Heat-Shock Response; Hepatocytes; Interleukin-6; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Oxidative Stress; Saponins; Signal Transduction; Superoxide Dismutase; Triterpenes | 2022 |
Astragaloside IV ameliorates pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension by restraining the T follicular helper cell response and expanding T follicular regulatory cell response.
Topics: Animals; Hypertension, Pulmonary; Hypoxia; Mice; Pulmonary Artery; Quality of Life; Saponins; Sildenafil Citrate; T Follicular Helper Cells; Triterpenes; Vascular Remodeling | 2022 |
Astragaloside IV attenuated TGF-β1- induced epithelial-mesenchymal transition of renal tubular epithelial cells via connexin 43 and Akt/mTOR signaling pathway.
Topics: Connexin 43; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Kidney Diseases; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; TOR Serine-Threonine Kinases; Transforming Growth Factor beta1; Triterpenes | 2022 |
Astragaloside IV Ameliorates Isoprenaline-Induced Cardiac Fibrosis in Mice
Topics: Akkermansia; Amino Acids; Animals; Bacteroidetes; Feces; Fibrosis; Gastrointestinal Microbiome; Isoproterenol; Male; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S; Saponins; Triterpenes | 2022 |
Astragaloside IV Alleviates Renal Tubular Epithelial-Mesenchymal Transition via CX3CL1-RAF/MEK/ERK Signaling Pathway in Diabetic Kidney Disease.
Topics: Animals; Chemokine CX3CL1; Diabetes Mellitus; Diabetic Nephropathies; Epithelial-Mesenchymal Transition; Fibrosis; Hyperglycemia; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Saponins; Signal Transduction; Triterpenes | 2022 |
Investigation on the potential targets of Astragaloside IV against intracerebral hemorrhage based on network pharmacology and experimental validation.
Topics: Animals; Cerebral Hemorrhage; Hematoma; Molecular Docking Simulation; Network Pharmacology; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Saponins; Stroke; Triterpenes | 2022 |
Astragaloside Ⅳ alleviates ulcerative colitis by regulating the balance of Th17/Treg cells.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL; Saponins; T-Lymphocytes, Regulatory; Th17 Cells; Triterpenes | 2022 |
A network pharmacology-based study on the mechanism of astragaloside IV alleviating renal fibrosis through the AKT1/GSK-3β pathway.
Topics: Animals; Epithelial-Mesenchymal Transition; Fibrosis; Glycogen Synthase Kinase 3 beta; Kidney Diseases; Molecular Docking Simulation; Network Pharmacology; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Saponins; Signal Transduction; Transforming Growth Factor beta1; Triterpenes | 2022 |
Effect of astragaloside IV on the immunoregulatory function of adipose-derived mesenchymal stem cells from patients with psoriasis vulgaris.
Topics: Adipose Tissue; B7-H1 Antigen; Cell Differentiation; Cells, Cultured; Humans; Mesenchymal Stem Cells; Osteogenesis; Psoriasis; Saponins; Transforming Growth Factor beta; Triterpenes; Tumor Necrosis Factor-alpha | 2022 |
[Molecular mechanism underlying difference of astragaloside Ⅳ content in imitating wild and cultivated Astragalus mongholicus].
Topics: Astragalus Plant; Astragalus propinquus; Saponins; Triterpenes | 2022 |
Protective effect of Astragalus membranaceus and Astragaloside IV in sepsis-induced acute kidney injury.
Topics: Acute Kidney Injury; Astragalus propinquus; Humans; Lipopolysaccharides; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Saponins; Sepsis; Triterpenes | 2022 |
Astragaloside IV Protects Detrusor from Partial Bladder Outlet Obstruction-Induced Oxidative Stress by Activating Mitophagy through AMPK-ULK1 Pathway.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy-Related Protein-1 Homolog; Female; Mitophagy; Muscle Contraction; Oxidative Stress; Rats; Saponins; Triterpenes; Urinary Bladder Neck Obstruction | 2022 |
Astragalus polysaccharides and astragaloside IV alleviate inflammation in bovine mammary epithelial cells by regulating Wnt/β-catenin signaling pathway.
Topics: Animals; Astragalus Plant; beta Catenin; Cattle; Epithelial Cells; Inflammation; Lipopolysaccharides; Polysaccharides; Saponins; Triterpenes; Wnt Signaling Pathway | 2022 |
Analysis of astragaloside IV metabolism to cycloastragenol in human gut microorganism, bifidobacteria, and lactic acid bacteria.
Topics: Bacteria; Bifidobacterium; Glucose; Humans; Lactobacillales; Sapogenins; Saponins; Triterpenes; Xylose | 2022 |
Astragaloside IV in Hypoxic Pulmonary Hypertension: an In Vivo and In Vitro Experiments.
Topics: Animals; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Rats; Saponins; Tumor Necrosis Factor-alpha | 2022 |
Astragaloside IV alleviates senescence of vascular smooth muscle cells through activating Parkin-mediated mitophagy.
Topics: Animals; beta-Galactosidase; Bleomycin; Cellular Senescence; Mice; Mitophagy; Muscle, Smooth, Vascular; Saponins; Triterpenes; Ubiquitin-Protein Ligases | 2022 |
Effect of astragaloside IV and salvianolic acid B on antioxidant stress and vascular endothelial protection in the treatment of atherosclerosis based on metabonomics.
Topics: Antioxidants; Atherosclerosis; Benzofurans; Endothelial Cells; Humans; Methionine; Saponins; Succinic Acid; Triterpenes | 2022 |
Astragaloside IV Protects Sepsis-induced Acute Kidney Injury by Attenuating Mitochondrial Dysfunction and Apoptosis in Renal Tubular Epithelial Cells.
Topics: Acute Kidney Injury; Animals; Apoptosis; Electron Transport Complex I; Epithelial Cells; Mice; Mitochondria; Saponins; Sepsis | 2022 |
Photoreceptor and vision protective effects of astragaloside IV in mice model with light-evoked retinal damage.
Topics: Animals; Disease Models, Animal; Mice; Retinal Cone Photoreceptor Cells; Retinal Degeneration; Saponins; Triterpenes | 2022 |
LC-MS/MS combined with blood-brain dual channel microdialysis for simultaneous determination of active components of astragali radix-safflower combination and neurotransmitters in rats with cerebral ischemia reperfusion injury: Application in pharmacokine
Topics: Animals; Aspartic Acid; Astragalus Plant; Blood-Brain Barrier; Carthamus tinctorius; Chalcone; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dopamine; Drugs, Chinese Herbal; gamma-Aminobutyric Acid; Glucosides; Glutamates; Microdialysis; Neurotransmitter Agents; Phenylpropionates; Quinones; Rats; Reperfusion Injury; Saponins; Serotonin; Tandem Mass Spectrometry; Triterpenes | 2022 |
Astragaloside IV ameliorates cerebral ischemia-reperfusion injury via upregulation of PKA and Cx36.
Topics: Animals; bcl-2-Associated X Protein; Brain Ischemia; Cerebral Infarction; Isoquinolines; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins; Sulfonamides; Triterpenes; Up-Regulation | 2022 |
Astragaloside IV ameliorates diet-induced hepatic steatosis in obese mice by inhibiting intestinal FXR via intestinal flora remodeling.
Topics: Animals; Bile Acids and Salts; Ceramides; Diet, High-Fat; Fibroblast Growth Factors; Gastrointestinal Microbiome; Glucagon-Like Peptide 1; Intestines; Liver; Mice; Mice, Inbred C57BL; Mice, Obese; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear; RNA, Ribosomal, 16S; Saponins; Sterols; Triterpenes | 2022 |
The bacterial consortia promote plant growth and secondary metabolite accumulation in Astragalus mongholicus under drought stress.
Topics: Astragalus propinquus; Bacteria; Droughts; Glucosides; Phosphates; Plant Roots; Plants; Potassium; Proline; Saponins; Siderophores; Superoxide Dismutase; Triterpenes; Water | 2022 |
Astragaloside IV ameliorates sepsis-induced myocardial dysfunction by regulating NOX4/JNK/BAX pathway.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Lipopolysaccharides; Myocytes, Cardiac; NADPH Oxidase 4; Rats; Rats, Sprague-Dawley; Saponins; Sepsis; Triterpenes | 2022 |
Antihypertension effect of astragaloside IV during cerebral ischemia reperfusion in rats.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Rats; Rats, Sprague-Dawley; Reperfusion; Reperfusion Injury; Saponins; Triterpenes | 2023 |
Biofilm inhibition based on controlling the transmembrane transport and extracellular accumulation of quorum sensing signals.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Biofilms; Eugenol; Quorum Sensing; Saponins | 2023 |
The combination of astragaloside IV and Panax notoginseng saponins attenuates cerebral ischaemia-reperfusion injury in rats through ferroptosis and inflammation inhibition via activating Nrf2.
Topics: Animals; Ferroptosis; Inflammation; NF-E2-Related Factor 2; Panax notoginseng; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Saponins | 2023 |
Astragaloside IV targets PRDX6, inhibits the activation of RAC subunit in NADPH oxidase 2 for oxidative damage.
Topics: Animals; Mice; NADPH Oxidase 2; Oxidative Stress; Peroxiredoxin VI; Phospholipases A2; Saponins | 2023 |
Systems pharmacology reveals the mechanism of Astragaloside IV in improving immune activity on cyclophosphamide-induced immunosuppressed mice.
Topics: Animals; Cyclophosphamide; Mice; Molecular Docking Simulation; Network Pharmacology; NF-kappa B; Saponins | 2023 |
Effects of borneol combined with astragaloside IV and Panax notoginseng saponins regulation of microglia polarization to promote neurogenesis after cerebral ischaemia.
Topics: Animals; Brain Ischemia; Microglia; Myeloid Differentiation Factor 88; Neurogenesis; NF-kappa B; Panax notoginseng; Rats; Reperfusion Injury; Saponins; Toll-Like Receptor 4 | 2023 |
Astragaloside IV ameliorate acute alcohol-induced liver injury in mice
Topics: Animals; Caspase 1; Chemical and Drug Induced Liver Injury, Chronic; Gastrointestinal Microbiome; Humans; Inflammasomes; Lipopolysaccharides; Liver; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Saponins; Signal Transduction | 2023 |
Astragaloside IV against Alzheimer's disease via microglia-mediated neuroinflammation using network pharmacology and experimental validation.
Topics: Alzheimer Disease; ErbB Receptors; Humans; Inflammation; Microglia; Molecular Docking Simulation; Network Pharmacology; Neuroinflammatory Diseases; Proto-Oncogene Proteins c-bcl-2; Saponins; Triterpenes | 2023 |
Astragaloside IV antagonizes the malignant progression of breast cancer induced by macrophage M2 polarization through the TGF-β-regulated Akt/Foxo1 pathway.
Topics: Breast Neoplasms; Female; Humans; Macrophages; Proto-Oncogene Proteins c-akt; Saponins | 2023 |
Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts through regulation of the HOXA6/ZBTB12 axis.
Topics: Cancer-Associated Fibroblasts; DNA-Binding Proteins; Genes, Homeobox; Humans; Saponins; Stomach Neoplasms; Transcription Factors; Tumor Microenvironment | 2023 |
Astragaloside IV inhibits experimental autoimmune encephalomyelitis by modulating the polarization of both microglia/macrophages and astrocytes.
Topics: Animals; Astrocytes; Encephalomyelitis, Autoimmune, Experimental; Humans; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Saponins | 2023 |