astemizole has been researched along with pyrilamine in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (38.10) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Janssen, M; Janssen, PA; Janssens, F; Luyckx, M; Stokbroekx, RA; Torremans, J | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Achterrath, U; Duflos, M; Emig, P; Fouchard, F; Günther, E; Kutscher, B; Le Baut, G; Menciu, C; Nickel, B; Schmidt, J; Szelenyi, I | 1 |
| Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD | 1 |
| Caron, G; Ermondi, G | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Axe, FU; Bembenek, SD; Butler, CR; Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Karlsson, L; Lundeen, K; Riley, JP; Savall, BM; Tays, KL; Wei, J; Williams, KN; Xue, X | 1 |
| Elz, S; Strasser, A; Wagner, E; Wittmann, HJ | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Carmody, LC; Dandapani, S; Donckele, E; Feng, Y; Fernandez, C; Germain, AR; Gupta, PB; Lander, ES; Morgan, B; Munoz, B; Nag, PP; Palmer, M; Perez, JR; Schreiber, SL; Verplank, L | 1 |
| Chen, G; Huang, G; Zhou, S | 1 |
| Adachi, Y; Fujisawa, K; Izushi, K; Kamei, C; Kitazumi, K; Mio, M; Tasaka, K; Tsujimoto, S | 1 |
| Luck, W; Simmet, T | 1 |
| Foxwell, MH; Johnson, DN; Kilpatrick, BF; Leonard, CA; Nolan, JC; Proakis, AG; Stephens, DJ; Yanni, JM | 1 |
| Niemegeers, CJ; Wauquier, A | 1 |
| Awouters, F; Janssen, PA; Van den Broeck, WA; Wauquier, A | 1 |
| Gommeren, W; Janssen, PF; Laduron, PM; Leysen, JE | 1 |
| Obel, AO | 1 |
| Guinosso, PJ; Jurkiewicz, NK; Lynch, JJ; Salata, JJ; Stupienski, RF; Wallace, AA | 1 |
21 other study(ies) available for astemizole and pyrilamine
| Article | Year |
|---|---|
New antihistaminic N-heterocyclic 4-piperidinamines. 2. Synthesis and antihistaminic activity of 1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-a mines.
Topics: Administration, Oral; Animals; Astemizole; Benzimidazoles; Chemical Phenomena; Chemistry; Guinea Pigs; Histamine; Histamine Antagonists; Male; p-Methoxy-N-methylphenethylamine; Piperidines; Pupil; Rats; Rats, Inbred Strains; Serotonin; Skin Tests; Structure-Activity Relationship | 1985 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
New N-(pyridin-4-yl)-(indol-3-yl)acetamides and propanamides as antiallergic agents.
Topics: Acetylcholine; Animals; Anti-Allergic Agents; Bronchoalveolar Lavage; Capillary Permeability; Carbachol; Eosinophilia; Guinea Pigs; Histamine Release; Hypersensitivity; In Vitro Techniques; Indoleacetic Acids; Interleukin-4; Interleukin-5; Male; Mast Cells; Muscle Contraction; Muscle, Smooth; Peritoneal Cavity; Polyunsaturated Alkamides; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Rhinitis, Allergic, Perennial; Structure-Activity Relationship; Trachea | 1999 |
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship | 2008 |
Mepyramine-JNJ7777120-hybrid compounds show high affinity to hH(1)R, but low affinity to hH(4)R.
Topics: Histamine H1 Antagonists; Indoles; Models, Molecular; Piperazines; Pyrilamine; Receptors, Histamine H1 | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Design, synthesis and biological activity of a novel ethylenediamine derivatives as H
Topics: Animals; Basophils; Cell Line; Chlorpheniramine; Drug Design; Ethylenediamines; Female; Guinea Pigs; Histamine H1 Antagonists; Humans; Male; Mice; Models, Molecular; Molecular Structure; Protein Conformation; Random Allocation; Rats; Receptors, Histamine H1 | 2019 |
Antiallergic effects of major metabolites of astemizole in rats and guinea pigs.
Topics: Animals; Astemizole; Binding, Competitive; Bronchoconstriction; Cerebellum; Guinea Pigs; Heart Rate; Histamine H2 Antagonists; Histamine Release; Hypersensitivity; In Vitro Techniques; Lung; Male; Muscle Contraction; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Pyrilamine; Rats; Rats, Inbred Strains | 1991 |
H1-antihistamines and calmodulin antagonists inhibit the ionophore A23187-induced eicosanoid formation by human leukocytes.
Topics: Astemizole; Benzimidazoles; Calcimycin; Calcium Channel Blockers; Eicosanoic Acids; Histamine H1 Antagonists; Humans; In Vitro Techniques; Indomethacin; Leukocytes; Masoprocol; Piperazines; Pyrilamine; Reference Values; Sulfonamides; Trifluoperazine | 1989 |
Rocastine (AHR-11325), a rapid acting, nonsedating antihistamine.
Topics: Anaphylaxis; Animals; Astemizole; Azepines; Benzhydryl Compounds; Benzimidazoles; Brompheniramine; Cats; Chlorpheniramine; Diphenhydramine; Electroencephalography; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; Kinetics; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Oxazepines; Piperazines; Promethazine; Pyrilamine; Terfenadine; Yohimbine | 1989 |
Effects of chlorpheniramine, pyrilamine and astemizole on intracranial self-stimulation in rats.
Topics: Animals; Astemizole; Benzimidazoles; Chlorpheniramine; Histamine H1 Antagonists; Neurotransmitter Agents; Physostigmine; Pupil; Pyrilamine; Rats; Self Stimulation | 1981 |
A comparison between astemizole and other antihistamines on sleep-wakefulness cycles in dogs.
Topics: Animals; Astemizole; Benzimidazoles; Chlorpheniramine; Diphenhydramine; Dogs; Histamine H1 Antagonists; Ketotifen; Male; Periodicity; Pyrilamine; Sleep; Sleep Stages; Sleep, REM; Wakefulness | 1981 |
In vitro and in vivo binding characteristics of a new long-acting histamine H1 antagonist, astemizole.
Topics: Animals; Astemizole; Benzimidazoles; Binding, Competitive; Brain; Guinea Pigs; Histamine Antagonists; Histamine H1 Antagonists; In Vitro Techniques; Lung; Pyrilamine; Rats; Rats, Inbred Strains; Spiperone; Time Factors | 1982 |
Practical therapeutics: the use of histamine receptor antagonists in contemporary times.
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Child; Cimetidine; Conjunctivitis, Allergic; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Pyrilamine; Rhinitis, Allergic, Seasonal; Terfenadine | 1984 |
Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine.
Topics: Action Potentials; Animals; Astemizole; Chlorpheniramine; Dose-Response Relationship, Drug; Electrocardiography; Guinea Pigs; Heart; In Vitro Techniques; Potassium Channels; Pyrilamine; Refractory Period, Electrophysiological; Terfenadine | 1995 |