astemizole and piperidines

astemizole has been researched along with piperidines in 25 studies

Research

Studies (25)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (16.00)	18.7374
1990's	7 (28.00)	18.2507
2000's	10 (40.00)	29.6817
2010's	2 (8.00)	24.3611
2020's	2 (8.00)	2.80

Authors

Authors	Studies
Goossens, JG; van Wauwe, JP	1
Janssen, M; Janssen, PA; Janssens, F; Luyckx, M; Stokbroekx, RA; Torremans, J	2
Nicholson, AN; Stone, BM	1
del Prado, M; Egan, RW; Hey, JA; Kreutner, W	1
Peláez, A	1
De Mol, NJ; Fischer, MJ; Janssen, LH; Kok-Van Esterik, JA; Paulussen, JJ; Van der Heijden, VS	1
Mattila, MJ; Paakkari, I	1
Gong, Q; January, CT; Vorperian, VR; Zhang, S; Zhou, Z	1
Roberts, DJ	1
Gong, Q; January, CT; Zhou, Z	1
Górska, M; Grzelewska-Rzymowska, I; Pietrzkowicz, M	1
Brown, AM; Ficker, E; Obejero-Paz, CA; Zhao, S	1
Paakkari, I	1
Hirama, T; Matsubara, T; Matsumoto, S; Nagata, K; Yamazoe, Y	1
Jeong, HE; Lee, SS; Liu, KH; Moon, T; Oh, SJ; Ryu, JY; Shin, JG; Yoon, CN; Yun, CH	1
Contreras-Jurado, C; Furini, S; García-Ferreiro, R; Gómez-Varela, D; Pardo, LA; Stühmer, W	1
Hefni, A; Lever, R; Moffatt, JD; Page, CP; Paul, W	1
Christ, A; Green, LG; Guba, W; Kratochwil, N; Martin, RE	1
Bissantz, C; Christ, A; Green, LG; Guba, W; Kratochwil, N; Martin, RE; Mauser, H; Roche, O; Stahl, M	1
Blay, J; Cowley, EA; Linsdell, P; Roy, J; Vantol, B	1
Cioc, RC; Maes, BU; Mampuys, P; Orru, RV; Ruijter, E; Vlaar, T	1
Jee, JG; Lee, J; Liu, KH; Park, SH; Phuc, NM; Shon, JC	1
Chen, LY; Xu, L	1
Asano, A; Ijiri, M; Ikenaka, Y; Ishizuka, M; Kawaguchi, H; Mizukawa, H; Murayama, N; Nakayama, SMM; Shiraishi, M; Teraoka, H; Uno, Y; Yamato, O; Yamazaki, H	1

Reviews

3 review(s) available for astemizole and piperidines

Article	Year
Variations among non-sedating antihistamines: are there real differences? European journal of clinical pharmacology, 1999, Volume: 55, Issue:2 Topics: Astemizole; Benzimidazoles; Butyrophenones; Central Nervous System; Cetirizine; Drug Interactions; Heart; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Piperidines; Potassium Channel Blockers; Terfenadine; Triprolidine	1999
[The effect of second generation histamine antagonists on the heart]. Pneumonologia i alergologia polska, 2001, Volume: 69, Issue:3-4 Topics: Animals; Area Under Curve; Astemizole; Butyrophenones; Electrocardiography; Heart; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Tachycardia; Terfenadine; Torsades de Pointes	2001
Cardiotoxicity of new antihistamines and cisapride. Toxicology letters, 2002, Feb-28, Volume: 127, Issue:1-3 Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Diseases; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Serotonin Receptor Agonists; Terfenadine; Triprolidine	2002

Trials

2 trial(s) available for astemizole and piperidines

Article	Year
Performance studies with the H1-histamine receptor antagonists, astemizole and terfenadine. British journal of clinical pharmacology, 1982, Volume: 13, Issue:2 Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cognition; Emotions; Female; Histamine H1 Antagonists; Humans; Mental Processes; Motor Skills; Piperidines; Terfenadine; Time Factors; Triprolidine	1982
Clinical efficacy of ebastine in the treatment and prevention of seasonal allergic rhinitis. Drugs, 1996, Volume: 52 Suppl 1 Topics: Astemizole; Butyrophenones; Double-Blind Method; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Seasonal; Seasons	1996

Other Studies

20 other study(ies) available for astemizole and piperidines

Article	Year
Arabinogalactan- and dextran-induced ear inflammation in mice: differential inhibition by H1-antihistamines, 5-HT-serotonin antagonists and lipoxygenase blockers. Agents and actions, 1989, Volume: 28, Issue:1-2 Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Aprotinin; Astemizole; Benzimidazoles; Benzoquinones; Cinanserin; Cyproheptadine; Dextrans; Galactans; Histamine H1 Antagonists; Kinetics; Lipoxygenase Inhibitors; Male; Metergoline; Mice; Otitis; Piperidines; Pyrazoles; Quinones; Ritanserin; Serotonin Antagonists	1989
New antihistaminic N-heterocyclic 4-piperidinamines. 2. Synthesis and antihistaminic activity of 1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-a mines. Journal of medicinal chemistry, 1985, Volume: 28, Issue:12 Topics: Administration, Oral; Animals; Astemizole; Benzimidazoles; Chemical Phenomena; Chemistry; Guinea Pigs; Histamine; Histamine Antagonists; Male; p-Methoxy-N-methylphenethylamine; Piperidines; Pupil; Rats; Rats, Inbred Strains; Serotonin; Skin Tests; Structure-Activity Relationship	1985
New antihistaminic N-heterocyclic 4-piperidinamines. 3. Synthesis and antihistaminic activity of N-(4-piperidinyl)-3H-imidazo[4,5-b]pyridin-2-amines. Journal of medicinal chemistry, 1985, Volume: 28, Issue:12 Topics: Administration, Oral; Aminopyridines; Animals; Astemizole; Benzimidazoles; Guinea Pigs; Histamine; Histamine Antagonists; Imidazoles; Male; p-Methoxy-N-methylphenethylamine; Piperidines; Rats; Rats, Inbred Strains; Structure-Activity Relationship	1985
Terfenadine, astemizole, and ebastine produce QTc interval prolongation in an experimental model predictive of adverse clinical ECG effects. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1996, Volume: 76, Issue:5 Topics: Animals; Astemizole; Butyrophenones; Electrocardiography; Guinea Pigs; Histamine H1 Antagonists; Models, Biological; Piperidines; Terfenadine	1996
Effects of the anti-allergics astemizole and norastemizole on Fc epsilon RI receptor-mediated signal transduction processes. European journal of pharmacology, 1997, Mar-12, Volume: 322, Issue:1 Topics: Animals; Anti-Allergic Agents; Astemizole; Benzimidazoles; Calcium; Cell Adhesion; Cell Line; Erythrocyte Membrane; Exocytosis; Fibronectins; Hemolysis; Hypotonic Solutions; Inosine Triphosphate; Piperidines; Protein Tyrosine Phosphatases; Rats; Receptors, IgE; Signal Transduction	1997
Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole. Journal of cardiovascular electrophysiology, 1999, Volume: 10, Issue:6 Topics: Astemizole; Benzimidazoles; Cation Transport Proteins; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Humans; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Terfenadine; Trans-Activators; Transcriptional Regulator ERG	1999
Cardiotoxicity of second-generation antihistamines. Drugs, 1999, Volume: 57, Issue:6 Topics: Astemizole; Butyrophenones; Heart Diseases; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine	1999
Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects. The Journal of biological chemistry, 1999, Oct-29, Volume: 274, Issue:44 Topics: Anti-Arrhythmia Agents; Astemizole; Biological Transport; Cation Transport Proteins; Cell Compartmentation; Cisapride; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Glycerol; Humans; Long QT Syndrome; Mutation; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Folding; Pyridines; Recombinant Proteins; Temperature; Trans-Activators; Transcriptional Regulator ERG	1999
The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations. The Journal of biological chemistry, 2002, Feb-15, Volume: 277, Issue:7 Topics: Anti-Arrhythmia Agents; Astemizole; Benzimidazoles; Binding Sites; Blotting, Western; Cation Transport Proteins; Cell Line; Cell Membrane; Cisapride; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Inhibitory Concentration 50; Ions; Long QT Syndrome; Models, Chemical; Mutagenesis, Site-Directed; Mutation; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Folding; Pyridines; Quaternary Ammonium Compounds; Quinidine; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG	2002
Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:11 Topics: Animals; Antibodies, Blocking; Arachidonic Acid; Astemizole; Blotting, Western; Butyrophenones; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Cloning, Molecular; COS Cells; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; DNA, Complementary; Enzyme Inhibitors; Gene Library; Histamine H1 Antagonists; Humans; In Vitro Techniques; Intestinal Mucosa; Mass Spectrometry; Microsomes, Liver; Oxygenases; Piperidines; Rabbits; Recombinant Proteins	2002
Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity. Pharmacogenetics and genomics, 2005, Volume: 15, Issue:2 Topics: Alleles; Animals; Astemizole; Butyrophenones; Catalysis; Cell Line; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; DNA Primers; Dose-Response Relationship, Drug; Gene Frequency; Genetic Variation; Heterozygote; Histamine H1 Antagonists; Humans; Insecta; Kinetics; Korea; Methylation; Models, Molecular; Mutation; Oxygenases; Piperidines; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Recombinant Proteins; Recombination, Genetic; Sequence Analysis, DNA; Time Factors	2005
Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide. FEBS letters, 2006, Sep-18, Volume: 580, Issue:21 Topics: Astemizole; Benzopyrans; Ether-A-Go-Go Potassium Channels; Humans; Imipramine; Ion Channel Gating; Models, Molecular; Phenethylamines; Piperidines; Point Mutation; Potassium Channel Blockers; Structure-Activity Relationship; Sulfonamides	2006
Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2007, Volume: 37, Issue:6 Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents; Astemizole; Benzimidazoles; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Dermatitis, Atopic; Dexamethasone; Disease Models, Animal; Endothelium, Vascular; Eosinophils; Guinea Pigs; Histamine H1 Antagonists; Humans; Inflammation; Intercellular Adhesion Molecule-1; Male; Mice; Mice, Inbred BALB C; Piperidines; Receptors, Histamine H1; Respiratory Hypersensitivity; Umbilical Veins; Vascular Cell Adhesion Molecule-1	2007
Discovery of the first nonpeptidic, small-molecule, highly selective somatostatin receptor subtype 5 antagonists: a chemogenomics approach. Journal of medicinal chemistry, 2007, Dec-13, Volume: 50, Issue:25 Topics: Amino Acid Sequence; Astemizole; Benzoxazoles; Binding Sites; Histamine H1 Antagonists; Humans; Molecular Sequence Data; Piperidines; Radioligand Assay; Receptors, Somatostatin; Sequence Homology, Amino Acid; Structure-Activity Relationship	2007
From astemizole to a novel hit series of small-molecule somatostatin 5 receptor antagonists via GPCR affinity profiling. Journal of medicinal chemistry, 2007, Dec-13, Volume: 50, Issue:25 Topics: Astemizole; Binding Sites; Combinatorial Chemistry Techniques; Databases, Factual; Histamine H1 Antagonists; Humans; Piperidines; Receptors, G-Protein-Coupled; Receptors, Somatostatin; Spiro Compounds; Structure-Activity Relationship	2007
Pharmacological separation of hEAG and hERG K+ channel function in the human mammary carcinoma cell line MCF-7. Oncology reports, 2008, Volume: 19, Issue:6 Topics: Adenocarcinoma; Anti-Allergic Agents; Anti-Arrhythmia Agents; Astemizole; Breast Neoplasms; Cell Proliferation; Cell Size; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Imipramine; Long QT Syndrome; Piperidines; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured	2008
Sustainable synthesis of diverse privileged heterocycles by palladium-catalyzed aerobic oxidative isocyanide insertion. Angewandte Chemie (International ed. in English), 2012, Dec-21, Volume: 51, Issue:52 Topics: Astemizole; Benzimidazoles; Catalysis; Cyanides; Diamines; Guanidines; Heterocyclic Compounds; Oxidation-Reduction; Palladium; Piperidines	2012
The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018, Mar-15, Volume: 42 Topics: Antineoplastic Agents, Phytogenic; Astemizole; Butyrophenones; Cell Proliferation; Chalcones; Chromatography, Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Forkhead Box Protein O3; Hep G2 Cells; Humans; Microsomes, Liver; Molecular Docking Simulation; Piperidines; Resorcinols; Tandem Mass Spectrometry	2018
Molecular determinant of substrate binding and specificity of cytochrome P450 2J2. Scientific reports, 2020, 12-17, Volume: 10, Issue:1 Topics: Arachidonic Acid; Astemizole; Butyrophenones; Catalytic Domain; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Molecular Docking Simulation; Oxidation-Reduction; Piperidines; Protein Binding; Substrate Specificity	2020
Cytochrome Drug metabolism and disposition: the biological fate of chemicals, 2022, Volume: 50, Issue:11 Topics: Animals; Astemizole; Butyrophenones; Cats; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dogs; Humans; Phylogeny; Piperidines; Swine; Terfenadine	2022