astemizole has been researched along with diphenhydramine in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (22.73) | 18.7374 |
| 1990's | 6 (27.27) | 18.2507 |
| 2000's | 7 (31.82) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cale, AD; Gero, TW; Jaques, LW; Johnson, AF; Johnson, DN; Leonard, CA; Lo, YS; Nolan, JC; Walker, KR; Welstead, WJ | 1 |
| Carrupt, PA; Jolliet, P; Morin, C; Morin, D; Pagliara, A; Rihoux, JP; Testa, B; Tillement, JP; Urien, S | 1 |
| Carrupt, PA; Crivori, P; Cruciani, G; Testa, B | 1 |
| Keserü, GM | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Caron, G; Ermondi, G | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Jia, L; Sun, H | 1 |
| Sen, S; Sinha, N | 1 |
| Elz, S; Strasser, A; Wagner, E; Wittmann, HJ | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Jancelewicz, Z; Sussman, G | 1 |
| Chand, N; Diamantis, W; Pillar, J; Sofia, RD | 1 |
| Foxwell, MH; Johnson, DN; Kilpatrick, BF; Leonard, CA; Nolan, JC; Proakis, AG; Stephens, DJ; Yanni, JM | 1 |
| Marzanatti, M; Monopoli, A; Ongini, E; Trampus, M | 1 |
| Awouters, F; Janssen, PA; Van den Broeck, WA; Wauquier, A | 1 |
| Biswas, K; Biswas, NR; Griyappanavar, CR; Lal, A; Sankaranarayanan, A; Sharma, PL; Tripathi, SK | 1 |
| Rice, VJ; Snyder, HL | 2 |
| Woosley, RL | 1 |
| Back, HM; Chae, JW; Kwon, KI; Lee, JH; Seo, JW; Song, B; Yun, HY | 1 |
1 review(s) available for astemizole and diphenhydramine
| Article | Year |
|---|---|
Cardiac actions of antihistamines.
Topics: Animals; Astemizole; Cetirizine; Diphenhydramine; Drug Interactions; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Terfenadine; Torsades de Pointes | 1996 |
4 trial(s) available for astemizole and diphenhydramine
| Article | Year |
|---|---|
Controlled trial of H1 antagonists in the treatment of chronic idiopathic urticaria.
Topics: Adult; Aged; Astemizole; Chronic Disease; Diphenhydramine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Hydroxyzine; Male; Middle Aged; Skin Tests; Urticaria | 1991 |
Evaluation of antimuscarinic activity in human volunteers: a teaching aid in clinical pharmacology.
Topics: Adult; Astemizole; Diphenhydramine; Education, Medical; Heart Rate; Humans; Male; Muscarinic Antagonists; Oxyphenonium; Pupil; Salivation; Students, Medical | 1995 |
The effects of Benadryl and Hismanal on mood, physiological measures, antihistamine detection, and subjective symptoms.
Topics: Adult; Affect; Astemizole; Blood Pressure; Body Temperature; Diphenhydramine; Double-Blind Method; Humans; Male; Perception; Pulse; Sleep Stages | 1993 |
The effects of Benadryl and Hismanal on psychomotor performance and perceived performance.
Topics: Adult; Astemizole; Cognition; Diphenhydramine; Humans; Male; Perception; Psychological Tests; Psychomotor Performance; Time Factors | 1993 |
17 other study(ies) available for astemizole and diphenhydramine
| Article | Year |
|---|---|
Benzo- and pyrido-1,4-oxazepin-5-ones and -thiones: synthesis and structure-activity relationships of a new series of H1 antihistamines.
Topics: Animals; Azepines; Cats; Chemical Phenomena; Chemistry; Female; Guinea Pigs; Histamine H1 Antagonists; Hypnotics and Sedatives; Male; Molecular Conformation; Oxazepines; Structure-Activity Relationship | 1989 |
Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist.
Topics: Alkanes; Animals; Biological Transport; Blood Proteins; Brain; Cetirizine; Histamine H1 Antagonists; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydroxyzine; Isomerism; Models, Molecular; Molecular Conformation; Octanols; Rats; Water | 1998 |
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Mepyramine-JNJ7777120-hybrid compounds show high affinity to hH(1)R, but low affinity to hH(4)R.
Topics: Histamine H1 Antagonists; Indoles; Models, Molecular; Piperazines; Pyrilamine; Receptors, Histamine H1 | 2011 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Inhibition of IgE-mediated allergic histamine release from rat peritoneal mast cells by azelastine and selected antiallergic drugs.
Topics: Animals; Astemizole; Benzimidazoles; Diphenhydramine; Histamine Release; Hypersensitivity; Immunoglobulin E; Ketotifen; Male; Mast Cells; Ovalbumin; Phosphatidylserines; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Theophylline | 1985 |
Rocastine (AHR-11325), a rapid acting, nonsedating antihistamine.
Topics: Anaphylaxis; Animals; Astemizole; Azepines; Benzhydryl Compounds; Benzimidazoles; Brompheniramine; Cats; Chlorpheniramine; Diphenhydramine; Electroencephalography; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; Kinetics; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Oxazepines; Piperazines; Promethazine; Pyrilamine; Terfenadine; Yohimbine | 1989 |
Effects of nonsedating histamine H1-antagonists on EEG activity and behavior in the cat.
Topics: Animals; Astemizole; Behavior, Animal; Benzhydryl Compounds; Benzimidazoles; Cats; Cyproheptadine; Diphenhydramine; Dose-Response Relationship, Drug; Electroencephalography; Histamine Antagonists; Histamine H1 Antagonists; Loratadine; Male; Phenothiazines; Sleep; Terfenadine | 1989 |
A comparison between astemizole and other antihistamines on sleep-wakefulness cycles in dogs.
Topics: Animals; Astemizole; Benzimidazoles; Chlorpheniramine; Diphenhydramine; Dogs; Histamine H1 Antagonists; Ketotifen; Male; Periodicity; Pyrilamine; Sleep; Sleep Stages; Sleep, REM; Wakefulness | 1981 |
A novel HPLC-MS/MS method for the simultaneous determination of astemizole and its major metabolite in dog or monkey plasma and application to pharmacokinetics.
Topics: Administration, Oral; Animals; Astemizole; Calibration; Chromatography, High Pressure Liquid; Diphenhydramine; Dogs; Haplorhini; Liquid-Liquid Extraction; Macaca fascicularis; Reproducibility of Results; Species Specificity; Tandem Mass Spectrometry; Trifluoroacetic Acid | 2015 |