astemizole and chlorpheniramine

astemizole has been researched along with chlorpheniramine in 28 studies

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (32.14)	18.7374
1990's	10 (35.71)	18.2507
2000's	6 (21.43)	29.6817
2010's	3 (10.71)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Abou-Gharbia, M; Moyer, JA; Nielsen, ST; Patel, U; Webb, M	1
Carrupt, PA; Jolliet, P; Morin, C; Morin, D; Pagliara, A; Rihoux, JP; Testa, B; Tillement, JP; Urien, S	1
Keserü, GM	1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD	1
Caron, G; Ermondi, G	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Jia, L; Sun, H	1
Sen, S; Sinha, N	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, G; Huang, G; Zhou, S	1
Feldman, W; Ham-pong, A; Leiken, L; Peterson, R; Shanon, A	1
Wood, SF	1
McMillan, JL; Simons, FE; Simons, KJ	1
Kaiser, HB	1
Foxwell, MH; Johnson, DN; Kilpatrick, BF; Leonard, CA; Nolan, JC; Proakis, AG; Stephens, DJ; Yanni, JM	1
Kacker, SK; Sooknundun, M; Sundaram, KR	1
Bhatti, JZ; Hindmarch, I	1
Chung, M; Simons, FE; Simons, KJ; Yeh, J	1
Meltzer, EO	1
Krause, LB; Shuster, S	1
Niemegeers, CJ; Wauquier, A	1
Awouters, F; Janssen, PA; Van den Broeck, WA; Wauquier, A	1
Chen, F; Dai, ZS; Hou, SX	1
Feldman, W; Leikin, L; Peterson, R; Pong, AH; Shanon, A; Williams, V	1
Guinosso, PJ; Jurkiewicz, NK; Lynch, JJ; Salata, JJ; Stupienski, RF; Wallace, AA	1
Crawford, WW; Klaustermeyer, WB; Lee, PH; Placik, IM	1
Chen, Z; Kamei, C; Kawamoto, E; Sugimoto, Y	1

Reviews

3 review(s) available for astemizole and chlorpheniramine

Article	Year
Central nervous system side-effects of antihistamines in schoolchildren. Rhinology. Supplement, 1992, Volume: 13 Topics: Astemizole; Central Nervous System Diseases; Child; Chlorpheniramine; Double-Blind Method; Histamine H1 Antagonists; Humans; Sleep Stages	1992
Clinical experience with non-sedating antihistamines in paediatric allergic rhinitis. Rhinology. Supplement, 1992, Volume: 13 Topics: Adolescent; Astemizole; Asthma; Child; Child, Preschool; Chlorpheniramine; Clinical Trials as Topic; Conjunctivitis, Allergic; Humans; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Terfenadine	1992
H1-receptor antagonist treatment of seasonal allergic rhinitis. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:6 Pt 2 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Chlorpheniramine; Clemastine; Cyproheptadine; Histamine H1 Antagonists; Humans; Hydroxyzine; Ketotifen; Loratadine; Rhinitis, Allergic, Seasonal; Terfenadine	1990

Trials

6 trial(s) available for astemizole and chlorpheniramine

Article	Year
Central nervous system side-effects of antihistamines in schoolchildren. Rhinology. Supplement, 1992, Volume: 13 Topics: Astemizole; Central Nervous System Diseases; Child; Chlorpheniramine; Double-Blind Method; Histamine H1 Antagonists; Humans; Sleep Stages	1992
A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:4 Pt 1 Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Chlorpheniramine; Cyproheptadine; Double-Blind Method; Histamine; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Male; Placebos; Skin Tests; Terfenadine; Time Factors; Urticaria	1990
Psychomotor effects of astemizole and chlorpheniramine, alone and in combination with alcohol. International clinical psychopharmacology, 1987, Volume: 2, Issue:2 Topics: Adult; Astemizole; Automobile Driving; Benzimidazoles; Chlorpheniramine; Drug Synergism; Ethanol; Female; Histamine H1 Antagonists; Humans; Middle Aged; Psychomotor Performance	1987
A comparison of astemizole and chlorpheniramine in dermographic urticaria. The British journal of dermatology, 1985, Volume: 112, Issue:4 Topics: Adolescent; Adult; Aged; Astemizole; Benzimidazoles; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Middle Aged; Pruritus; Skin; Sleep Stages; Urticaria	1985
Comparison of CNS adverse effects between astemizole and chlorpheniramine in children: a randomized, double-blind study. Developmental pharmacology and therapeutics, 1993, Volume: 20, Issue:3-4 Topics: Adolescent; Astemizole; Attention; Behavior; Central Nervous System; Child; Chlorpheniramine; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Memory, Short-Term; Multivariate Analysis; Patient Compliance; Psychomotor Performance; Rhinitis, Allergic, Seasonal	1993
Comparative efficacy of terfenadine, loratadine, and astemizole in perennial allergic rhinitis. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1998, Volume: 118, Issue:5 Topics: Adrenergic Agents; Allergens; Ambulatory Care; Analysis of Variance; Anti-Allergic Agents; Astemizole; Bronchodilator Agents; Chlorpheniramine; Confidence Intervals; Cross-Over Studies; Ephedrine; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Nasal Mucosa; Nose; Rhinitis, Allergic, Perennial; Skin Tests; Terfenadine; Treatment Outcome	1998

Other Studies

20 other study(ies) available for astemizole and chlorpheniramine

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
New antihistamines: substituted piperazine and piperidine derivatives as novel H1-antagonists. Journal of medicinal chemistry, 1995, Sep-29, Volume: 38, Issue:20 Topics: Animals; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Male; Motor Activity; Piperazines; Piperidines; Rats; Structure-Activity Relationship	1995
Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist. Journal of medicinal chemistry, 1998, Mar-12, Volume: 41, Issue:6 Topics: Alkanes; Animals; Biological Transport; Blood Proteins; Brain; Cetirizine; Histamine H1 Antagonists; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydroxyzine; Isomerism; Models, Molecular; Molecular Conformation; Octanols; Rats; Water	1998
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18 Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2004
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Design, synthesis and biological activity of a novel ethylenediamine derivatives as H Bioorganic & medicinal chemistry, 2019, 12-15, Volume: 27, Issue:24 Topics: Animals; Basophils; Cell Line; Chlorpheniramine; Drug Design; Ethylenediamines; Female; Guinea Pigs; Histamine H1 Antagonists; Humans; Male; Mice; Models, Molecular; Molecular Structure; Protein Conformation; Random Allocation; Rats; Receptors, Histamine H1	2019
Rocastine (AHR-11325), a rapid acting, nonsedating antihistamine. Agents and actions, 1989, Volume: 28, Issue:1-2 Topics: Anaphylaxis; Animals; Astemizole; Azepines; Benzhydryl Compounds; Benzimidazoles; Brompheniramine; Cats; Chlorpheniramine; Diphenhydramine; Electroencephalography; Female; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; Kinetics; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Oxazepines; Piperazines; Promethazine; Pyrilamine; Terfenadine; Yohimbine	1989
Treatment of allergic rhinitis with a new long-acting H1 receptor antagonist: astemizole. Annals of allergy, 1987, Volume: 58, Issue:1 Topics: Adult; Appetite; Astemizole; Benzimidazoles; Chlorpheniramine; Drug Evaluation; Female; Histamine H1 Antagonists; Humans; Male; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sleep Stages; Xerostomia	1987
The comparative pharmacokinetics of H1-receptor antagonists. Annals of allergy, 1987, Volume: 59, Issue:6 Pt 2 Topics: Adult; Age Factors; Astemizole; Benzhydryl Compounds; Benzimidazoles; Brompheniramine; Cetirizine; Child; Chlorpheniramine; Dose-Response Relationship, Drug; Half-Life; Histamine H1 Antagonists; Humans; Hydroxyzine; Terfenadine	1987
The use of antihistamines for the treatment of airway disease. Cutis, 1988, Oct-27, Volume: 42, Issue:4A Topics: Astemizole; Asthma; Benzhydryl Compounds; Benzimidazoles; Child; Chlorpheniramine; Double-Blind Method; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Seasonal; Terfenadine	1988
Effects of chlorpheniramine, pyrilamine and astemizole on intracranial self-stimulation in rats. European journal of pharmacology, 1981, Jun-19, Volume: 72, Issue:2-3 Topics: Animals; Astemizole; Benzimidazoles; Chlorpheniramine; Histamine H1 Antagonists; Neurotransmitter Agents; Physostigmine; Pupil; Pyrilamine; Rats; Self Stimulation	1981
A comparison between astemizole and other antihistamines on sleep-wakefulness cycles in dogs. Neuropharmacology, 1981, Volume: 20, Issue:9 Topics: Animals; Astemizole; Benzimidazoles; Chlorpheniramine; Diphenhydramine; Dogs; Histamine H1 Antagonists; Ketotifen; Male; Periodicity; Pyrilamine; Sleep; Sleep Stages; Sleep, REM; Wakefulness	1981
Inhibitory effects of chlorpheniramine and astemizolum on contraction of isolated rat and rabbit uteri induced by oxytocin and PGF2 alpha. Journal of Tongji Medical University = Tong ji yi ke da xue xue bao, 1994, Volume: 14, Issue:3 Topics: Animals; Astemizole; Chlorpheniramine; Dinoprostone; Female; In Vitro Techniques; Oxytocin; Rabbits; Rats; Rats, Wistar; Uterine Contraction	1994
Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine. Circulation research, 1995, Volume: 76, Issue:1 Topics: Action Potentials; Animals; Astemizole; Chlorpheniramine; Dose-Response Relationship, Drug; Electrocardiography; Guinea Pigs; Heart; In Vitro Techniques; Potassium Channels; Pyrilamine; Refractory Period, Electrophysiological; Terfenadine	1995
A new model of allergic rhinitis in rats by topical sensitization and evaluation of H(1)-receptor antagonists. Immunopharmacology, 2000, Volume: 48, Issue:1 Topics: Allergens; Animals; Anti-Allergic Agents; Astemizole; Chlorpheniramine; Dibenzazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Imidazoles; Immunization; Ketotifen; Nasal Cavity; Ovalbumin; Passive Cutaneous Anaphylaxis; Rats; Rats, Wistar; Rhinitis, Allergic, Perennial; Sneezing; Time Factors	2000