asteltoxin and avenaciolide

A strategy for the synthesis of chiral molecules that receives growing popularity among organic chemists employs the photochemically mediated [2 + 2] cycloaddition reaction. These reactions can be performed on a multigram scale and often proceed with high yield and with stereocontrol. These features, in combination with the useful properties of the four-membered ring photoproducts in subsequent chemical transformations, make them attractive options in the early stage of a synthesis design. Various combinations of unsaturated functional groups can participate in this reaction process. Accordingly, these chemical reactions can be economical solutions to problems relating to the synthesis of a variety of target molecules.

Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Chemical Phenomena; Chemistry; Cockroaches; Female; Furans; Lactones; Male; Mycotoxins; Photochemistry; Pyrones; Sex Attractants; Stereoisomerism