aspirin has been researched along with thromboxane b2 in 828 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 284 (34.30) | 18.7374 |
| 1990's | 219 (26.45) | 18.2507 |
| 2000's | 157 (18.96) | 29.6817 |
| 2010's | 150 (18.12) | 24.3611 |
| 2020's | 18 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Blombäck, M; Hamberg, M; Svensson, J | 1 |
| Johnson, MC; Kelly, JP; Parker, CW | 1 |
| Castrucci, G; Ciabattoni, G; De Salvo, A; Parachini, M; Patrono, C; Pinca, E; Pugliese, F; Satta, MA | 2 |
| Okuma, M; Uchino, H | 1 |
| Marcus, AJ | 1 |
| Bailey, JM; Butler, J; Makheja, AN; Salata, K | 1 |
| Chang, WC; Murota, SI; Tsurufuji, S | 1 |
| Björck, T; Dahlén, B; Dahlén, SE; Granström, E; Kumlin, M; Zetterström, O | 1 |
| Bizzi, B; Castellana, MA; Ciabattoni, G; Landolfi, R; Patrignani, P; Patrono, C; Pogliani, E | 1 |
| Christiansen, SC; Juergens, UR; Stevenson, DD; Zuraw, BL | 2 |
| Chen, YC; Huang, ZS; Lee, TK; Ng, SK | 1 |
| Hamm, CW; Kupper, W; Ruchelka, A; Terres, W; Weilepp, A | 1 |
| Burhop, KE; Estep, T; Farrell, L; Nigro, C; Tan, D | 1 |
| Hayashi, Y; Nakahama, H; Nakanishi, T; Shimizu, S; Sugita, M; Takiguchi, A; Uyama, O; Yamamoto, S | 1 |
| Husted, SE; Kristensen, SD; Mørn, B; Nielsen, HK; Schmidt, EB; Vissinger, H | 1 |
| Kawano, K; Kimura, B; Konno, S; Tamura, K; Tohgi, H | 1 |
| Diss, EM; Gabbe, SG; Kniss, DA; Moore, JW | 1 |
| Simmet, T; Tschorn, K; Weide, I | 1 |
| Edhag, O; Gréen, K; Henriksson, P; Rasmanis, G; Vesterqvist, O | 1 |
| Bleifeld, W; Krüger, K; Terres, W | 1 |
| Ardlie, NG; Bartlett, MR; McGuiness, JA; Selley, ML | 1 |
| Mochizuki, M; Morikawa, H; Ohashi, M; Takashima, M; Yamasaki, M | 1 |
| Giessler, C; Heinroth-Hoffmann, I; Mest, HJ | 1 |
| Craven, PA; DeRubertis, FR | 1 |
| Albanese, S; Bianchi, C; Ciabattoni, G; Coppola, E; Lanza, GA; Natale, A; Rebuzzi, AG | 1 |
| Burke, V; Douglas, AJ; McCulloch, RK; Mori, TA; Vandongen, R | 1 |
| Matsumoto, T; Toda, N; Yoshida, K | 1 |
| Ohkubo, H; Ohmuro, S; Taga, F; Tsukada, Y; Uchida, H | 1 |
| Axford, T; Feingold, H; Gray, AD; Khabbaz, K; Khuri, SF; Marquardt, C; Ragno, G; Valeri, CR | 1 |
| Broughton Pipkin, F; Fox, S; Heptinstall, S; Louden, KA; Mitchell, JR; O'Callaghan, C; Symonds, EM; Tuohy, P | 1 |
| de la Cruz, JP; Mata, JM; Sanchez de la Cuesta, F | 1 |
| Olsen, JO; Osterud, B; Wilsgård, L | 1 |
| Dupont, J; Krumhardt, B | 1 |
| Addonizio, VP; Bell, P; Campbell, F; Ellison, N; Fisher, CA; Kappa, JR; Stenach, N; Todd, B | 1 |
| Ditter, H; Matthias, FR | 1 |
| Aznar, J; Broekman, MJ; Marcus, AJ; Martinez-Sales, V; Portoles, M; Safier, LB; Santos, MT; Valles, J | 1 |
| Breimer, DD; Cohen, AF; Danhof, M; de Boer, A; Magnani, HN | 1 |
| Chiabrando, C; Fanelli, R; Martelli, L; Rivoltella, L; Valzacchi, S | 1 |
| Abbas, NA; Hirschelmann, R; Mest, HJ; Taube, C | 1 |
| Charman, SA; Charman, WN; FitzGerald, GA; Lupinetti, M | 1 |
| Khosseĭn Shakhavat, AF; Shelest, AN; Shushliapin, OI | 1 |
| Cheng, WW; Zhang, ZJ | 1 |
| Förster, W; Hoffman, W | 1 |
| Keery, RJ; Lumley, P; Watts, IS; Wharton, KA; White, BP | 1 |
| Ciabattoni, G; Davì, G; Patrono, C | 2 |
| McLeod, LJ; Roberts, MS; Vial, JH | 1 |
| Bhakdi, S; Eberspächer, B; Grimminger, F; Holland, IB; Hugo, F; Obernitz, R; Seeger, W; Suttorn, N; Thomas, M; Walmrath, D | 1 |
| Bernini, W; Buti Strata, G; De Caterina, R; Giannessi, D; Lazzerini, G; Sicari, R | 1 |
| Barrow, DV; Gross, PL; Packham, MA; Rand, ML | 1 |
| Cole, AT; Hawkey, CJ; Hawthorne, AB; Mahida, YR | 1 |
| Asai, F; Ito, T; Matsuda, K; Oshima, T; Ushiyama, S | 1 |
| Cambridge, H; Hooke, RE; Lees, P; Russell, CS | 1 |
| Cattaneo, M; Lecchi, A; Mannucci, PM; Tenconi, PM | 1 |
| Bauman, JE; Domoto, DT; Joist, JH | 1 |
| Benedict, CR; Buja, LM; Campbell, WB; Falinska, B; McNatt, J; Rosolowsky, M; Willerson, JT; Yao, SK | 1 |
| Fitzgerald, DJ; FitzGerald, GA; Mayo, G; Murray, R; Rocki, W | 1 |
| Ahmed, Y; Elder, MG; Sullivan, MH | 1 |
| Eldor, A; Goldfarb, A; Lellouche, F; Maclouf, J; Rachmilewitz, EA | 1 |
| Lefort, J; Lellouch-Tubiana, A; Terlain, B; Vannier, E; Vargaftig, BB | 1 |
| Bucchi, F; Cerletti, C; Davies, JA; de Gaetano, G; Donati, MB; Hampton, KK; Loizou, LA; Prentice, CR | 1 |
| Grabowski, EF | 1 |
| Burch, JW; Burch, PT | 1 |
| Antonucci, R; Herion, J; Orringer, E; Walker, R | 1 |
| Boem, A; Ciabattoni, G; De Caterina, R; Gazzetti, P; Giannessi, D; Patrono, C; Sicari, R | 1 |
| Akagi, T; Inoue, O; Kato, H; Sato, N | 1 |
| McLeod, LJ; Roberts, MS; Seville, PR; Vial, JH | 1 |
| Covatto, RH; Niewiarowski, S | 1 |
| Arnout, J; De Reys, S; Deckmyn, H; Falcon, C; Hoet, B; Vermylen, J | 1 |
| Bochner, F; Duncan, EM; Lloyd, JV; Siebert, DM; Somogyi, AA; Wilson, KM | 1 |
| Hamano, S; Ikeda, S; Kikuchi, S; Kojima, M; Komatsu, H; Kusama, H; Okegawa, T; Takehana, Y | 1 |
| Arnljots, B; Dougan, P; Salemark, L; Wieslander, JB | 1 |
| Brown, CE; Cox, K; Gant, NF; Magness, RR; Rosenfeld, CR; Spitz, B | 1 |
| Bochner, F; Lloyd, JV; Rodgers, SE; Vanags, D | 1 |
| Alberti, P; Corona, C; Gresele, P; Nenci, GG | 1 |
| Grande, P; Grauholt, AM; Midttun, M | 1 |
| Fuller, RW; Joyce, H; Lim, TK; Pride, NB; Turner, NC; Watson, A | 1 |
| Hato, T; Kobayashi, Y; Okuda, H; Sumida, M; Watanabe, A; Yasukawa, M | 1 |
| Eckert, B; Thorngren, M; Vinge, E | 1 |
| Mikashima, H; Muramoto, Y | 1 |
| Anton, RF; Becker, HC; Randall, CL | 1 |
| Averna, M; Catalano, I; Ciabattoni, G; Davì, G; Notarbartolo, A; Patrono, C; Strano, A | 1 |
| Elder, MG; Gleeson, RP; Sullivan, MH; Zosmer, A | 1 |
| Born, GV; Ciabattoni, G; Fragasso, G; Hackett, D; Lipkin, DP; Maseri, A; Patrono, C; Vejar, M | 1 |
| Brunelli, C; Caponnetto, S; Galassi, AR; Hackett, D; Ianetti, M; Lipkin, D; Maseri, A; Patrono, C; Spallarossa, P; Vejar, M | 1 |
| Girolami, A; Martinelli, S; Patrassi, GM; Picchinenna, A | 1 |
| Fabris, F; Girolami, A; Luzzatto, G; Mazzucato, M | 1 |
| Fulton, DR; Meissner, C; Peterson, MB | 1 |
| Hato, T; Ikeda, K; Kobayashi, Y; Watanabe, A; Yasukawa, M | 1 |
| Disa, J; Kowalska, MA; Rao, AK | 1 |
| Begnis, R; Benigni, A; Garattini, S; Livio, M; Morelli, C; Remuzzi, G; Rossini, M; Zoja, C | 1 |
| Kadowitz, PJ; Mayeux, PR; McNamara, DB | 1 |
| Peskar, BA; Sinzinger, H; Virgolini, I | 1 |
| Abbate, M; Benigni, A; Bergamelli, A; Bertani, T; Livio, M; Orisio, S; Remuzzi, G; Zoja, C | 1 |
| Fujii, Y; Sakurai, J | 1 |
| Lages, B; Weiss, HJ | 1 |
| Bleifeld, W; Kupper, W; Schuster, O; Terres, W | 1 |
| Davies, BH; Pawlowicz, A; Williams, WR | 1 |
| Brenner, B; Eichler, HG; Heistinger, M; Kyrle, PA; Lechner, K; Marosi, L; Minar, E | 1 |
| Catella, F; Fitzgerald, GA; Lupinetti, MD; Sheller, JR | 1 |
| Chenoweth, DE; Engler, RL; Ito, BR; Lefer, AM; Roth, DM | 1 |
| Carpenter-Deyo, L; Roth, RA | 1 |
| Chakraborti, S; Gurtner, GH; Michael, JR | 1 |
| Cook, JA; Halushka, PV; Heffner, JE | 1 |
| Bonta, IL; Elliott, GR; Lauwen, AP | 1 |
| Gentry, PA; Liptrap, RM; Niemuller, C; Ross, ML | 1 |
| Barrow, SE; Beacham, J; Cockcroft, JR; Doktor, HS; Ritter, JM | 1 |
| Chen, YC; Huang, ZS; Kuo, TL; Lee, TK; Lien, IN; Liu, MC | 1 |
| Capaldi, L; Folli, G; Guerrera, G; Melina, D; Satta, MA; Scoppola, A | 1 |
| Ballerini, S; Benigni, A; Chiabrando, C; Fanelli, R; Frusca, T; Gregorini, G; Orisio, S; Piccinelli, A; Pinciroli, V; Valcamonico, A | 1 |
| Faergeman, O; Husted, SE; Kraemmer Nielsen, H; Krusell, LR | 1 |
| Heng, MC; Heng, MK; Song, MK | 1 |
| Danesh, BJ; Forbes, CD; Lowe, GD; McLaren, M; Russell, RI | 1 |
| Benigni, A; Chiabrando, C; Fanelli, R; FitzGerald, GA; Patrono, C; Perico, N; Remuzzi, G | 1 |
| McCulloch, RK; Rouse, IL; Summers, J; Vandongen, R | 1 |
| Chesney, CM; Leffler, C; Mirro, R; Sibai, BM | 1 |
| Joyce, RM; McLeod, LJ; Roberts, MS; Seville, PR; Vial, JH | 1 |
| Koyama, T; Maruyama, Y; Numano, F | 1 |
| Docherty, JC; Gerrard, JM; Kobrinsky, NL; Kostolansky, I; McKenzie, JK; McNicol, A; Rowe, R; Singhroy, S; Taback, S | 1 |
| Frölich, JC; Küster, LJ | 2 |
| Andou, K; Kobayashi, N; Maekawa, T; Takada, M | 1 |
| Barlow, B; Connellan, JM; Lowe, M; McKenzie, IF; Thurlow, PJ | 1 |
| Callow, AD; Connolly, RJ; Eldrup-Jorgensen, J; Mackey, WC; O'Donnell, TF; Ramberg, K; Valeri, CR | 1 |
| Kakkar, VV; Kyrle, PA; Lewis, GP; Scully, MF; Westwick, J | 1 |
| Cronenwett, JL; Huntsman, WT; McDaniel, MD; Miett, TO | 1 |
| FitzGerald, GA; Nowak, J | 1 |
| Barsacchi, R; De Caterina, R; Giannessi, D; Lazzerini, G; Nanni, N; Pelosi, G | 1 |
| Boss, AH; Catella, F; Ciabattoni, G; Daffonchio, L; Daugherty, J; Dray, F; FitzGerald, GA; Patrono, C | 1 |
| Catella, F; Fitzgerald, DJ; FitzGerald, GA; Lawson, JA | 1 |
| De la Cruz, JP; Garcia-Arnes, J; Pavia, J; Sanchez de la Cuesta, F | 1 |
| Berk, L; van der Giessen, WJ; Verdouw, PD; Zijlstra, FJ | 1 |
| Palmer, RM; Salmon, JA | 1 |
| Hiller, E; Höfling, B; Riess, H; von Arnim, T | 1 |
| Altman, R; Cacchione, R; Rouvier, J; Scazziota, A | 1 |
| Bucchi, F; Cerletti, C; de Gaetano, G | 1 |
| Brath, PC; Thorp, JA; Walsh, SW | 1 |
| Barabás, K; Matkovics, B; Mézes, M | 1 |
| Ciabattoni, G; Cominelli, F; Gentilini, P; La Villa, G; Laffi, G; Mannelli, M; Patrignani, P; Pinzani, M | 1 |
| Huijgens, PC; Imandt, LM; Langenhuijsen, MM; Miltenburg, A; van den Berg, CA | 1 |
| Emms, H; Lewis, GP | 1 |
| Buchanan, MR; Butt, RW; Hirsh, J; Markham, BA; Nazir, DJ | 1 |
| Fischer, C; Frölich, JC; Meese, CO; Rosenkranz, B | 1 |
| Kyrle, P; Poll, C; Westwick, J | 1 |
| Bartolini, G; Chiricolo, M; Fidan, M; Franceschi, C; Guerrini, F; Minghetti, L; Orlandi, M; Tomasi, V | 1 |
| Ciabattoni, G; Fitzgerald, GA; Lawson, JA; Patrono, C | 1 |
| Cerletti, C; de Gaetano, G; Gambino, MC; Garattini, S | 1 |
| Setty, BN; Stuart, MJ; Walenga, RW; Wall, SF | 1 |
| Altman, R; Scazziota, A | 1 |
| Ghai, R; Lindsay, LA; Olson, RW; Sakane, Y; Smith, EF | 1 |
| Bush, HL; Curl, GR; Deykin, D; Jakubowski, JA | 1 |
| Cerbone, AM; DiMinno, G; Murphy, S; Silver, MJ | 1 |
| Eynard, A; Galli, G; Gregori, M; Maderna, P; Tremoli, E | 1 |
| Boukili, MA; Bureau, M; Lagente, V; Lefort, J; Lellouch-Tubiana, A; Malanchère, E; Vargaftig, BB | 1 |
| Deykin, D; Faigel, D; Jakubowski, JA; Stampfer, MJ; Vaillancourt, R | 1 |
| Bucchi, F; Cerletti, C; de Goetano, G; Gambino, MC; Rajtar, G; Riva, E | 1 |
| Henderson, B; Higgs, GA; Salmon, JA; Vane, JR | 1 |
| Bodzenta, A; Bucchi, F; Cerletti, C; de Gaetano, G | 1 |
| Kagawa, K; Kagawa, T; Kasahara, K; Masuda, A; Nonoyama, A; Omoto, K; Sakurai, Y | 1 |
| Ambler, J; Butler, KD; Butler, PA; Shand, RA; Wallis, RB | 1 |
| Costantini, V; Goracci, G; Nenci, GG; Pistolesi, R; Porcellati, S; Porrovecchio, P; Prosdocimi, M | 1 |
| Rak, K; Török, I; Udvardy, M | 1 |
| Farquhar, C; Ritter, JM; Rodin, A; Thom, MH | 1 |
| Anderson, CB; Freeman, MB; Mangino, MJ; Neuberger, S; Sicard, GA; Valentin, LI | 1 |
| Berndt, J; Hamm, U; Krug, HF | 1 |
| Bucchi, F; Cerletti, C; Chen, ZM; de Gaetano, G; Gambino, MC; Gori, G; Latini, R; Passaghe, S | 1 |
| Boysen, G; Knudsen, JB; Petersen, P; Waldemar, G | 1 |
| Allen, BT; Anderson, CB; Freeman, MB; McGoff, MA; Sicard, GA; Valentin, LI | 1 |
| Altman, R; Funes, JC; Scazziota, A | 1 |
| Hamasaki, Y; Ichimaru, T; Miyazaki, S; Tasaki, H | 1 |
| Förster, W; Lueddeckens, G; Schaper, U; Scheuch, DW | 1 |
| Bernini, W; Boem, A; De Caterina, R; Filabozzi, P; Giannessi, D; Patrignani, P; Patrono, C | 1 |
| Brown, CE; Cox, SM; Gant, NF; Magness, RR; Rosenfeld, CR; Spitz, B | 1 |
| Caruso, D; Galli, G; Maderna, P; Tremoli, E | 1 |
| Fitscha, P; Kaliman, J; O'Grady, J; Sinzinger, H | 1 |
| Hauser, A; Heinroth-Hoffmann, I; Mest, HJ; Taube, C | 1 |
| Grandjean, CJ; Park, JH; Vanderhoof, JA | 1 |
| FitzGerald, GA; Healy, C; Knapp, HR; Lawson, J | 1 |
| Frazer, CE; Ritter, JM | 1 |
| Cerletti, C; de Gaetano, G; Dejana, E; Domanin, M; Latini, R; Lauri, D; Lorenzi, G; Marchi, S; Urso, R | 1 |
| Beckman, J; Klein, RC; Peake, G | 1 |
| Konturek, SJ; Kwiecień, N; Obtułwicz, W; Oleksy, J | 1 |
| Donadio, JV; Holley, KE; Ilstrup, DM; Romero, JC | 1 |
| McLeod, LJ; Roberts, MS; Seville, PR | 1 |
| Agusti-Vidal, A; Castillo, JA; Coronas, A; Ordinas, A; Picado, C; Pujades, M; Schinca, N | 1 |
| Gaspari, F; Locatelli, M; Remuzzi, G; Viganò, G | 1 |
| Fujitani, RM; Marcus, CS; Nordestgaard, AG; Wilson, SE | 1 |
| Chen, YC; Huang, ZS; Lee, TK; Lien, IN; Liu, MC | 1 |
| Fitscha, P; Kaliman, J; Silberbauer, K; Sinzinger, H | 1 |
| Kimura, B; Kimura, M; Suzuki, H; Tamura, K; Tohgi, H | 1 |
| Christakis, GT; Ivanov, J; Levitt, DS; Madonik, MM; Mee, AV; Reilly, PA; Rosenfeld, JM; Teoh, KH; Weisel, RD; Wong, PY | 1 |
| Anttila, M; Kahela, P; Uotila, P | 1 |
| Catella, F; FitzGerald, GA; Healy, D; Lawson, JA | 1 |
| Bochner, F; Duncan, EM; Herd, CM; Lloyd, JV; Rodgers, SE; Tunbridge, LJ | 1 |
| Benveniste, J; Brink, C; Brunelleschi, S; Haye-Legrand, I; Labat, C; Norel, X | 1 |
| Konturek, SJ; Kopp, B; Kwiecień, N; Obtułowicz, W; Oleksy, J | 1 |
| Barbui, T; Buelli, M; Cortelazzo, S; De Gaetano, G; Viero, P | 1 |
| Granack, K; Hamilton, J; Subbarao, V; Ts'ao, C | 1 |
| Vesterqvist, O | 1 |
| Kääpä, P; Mäkilä, UM; Viinikka, L; Ylikorkala, O | 1 |
| Aiken, JW; Humphrey, WR; Weselcouch, EO | 1 |
| Gay, WA; Karwande, SV; Subramanian, VA; Weksler, BB | 1 |
| Eichler, HG; Jäger, U; Kyrle, PA; Lechner, K | 1 |
| de Groot, PG; Kallmann, R; Nieuwenhuis, HK; Sixma, JJ; van Gijn, J | 1 |
| Inaba, M; Ishii, J; Katayama, S; Kawazu, S; Maruno, Y; Omoto, A | 1 |
| Chen, YC; Kuo, TL; Lee, TK | 1 |
| Angoli, L; Bramucci, E; Bré, E; Corsico, G; De Servi, S; Ferrario, M; Ghio, S; Mussini, A; Poma, E; Rondanelli, R | 1 |
| Ang, A; Chen, YC; Kuo, TL; Lee, TK; Lien, IN; Liu, MC | 1 |
| Carey, F; Haworth, D | 1 |
| Carriero, MR; Cerletti, C; de Gaetano, G; Mussoni, L | 1 |
| Filep, J; Frölich, JC; Küster, LJ | 1 |
| FitzGerald, GA; Reilly, IA | 1 |
| Buckels, JA; Nordestgaard, AG; Wilson, SE | 1 |
| Baxter, GM; Moore, JN | 1 |
| Butler, J; Jindal, SK; Kirk, W; Lakshminarayanan, S | 1 |
| Cerletti, C; Costantini, V; De Amicis, G; de Gaetano, G; Dejana, E; Lorenzi, G | 1 |
| Frölich, JC; Rosenkranz, B | 1 |
| Isomäki, H; Laitinen, O; Nissilä, M; Nuotio, P; Nykänen, E; Seppälä, E; Vapaatalo, H | 1 |
| Chang, SF; Goldlust, MB; Harrison, LI; McQuain, C; Morris, HG; Sherman, NA | 1 |
| Brooks, P; Byars, TD; Kopp, KJ; Moore, JN | 1 |
| Bertelé, V; Castagnoli, MN; Cerletti, C; de Gaetano, G; Rajtar, G | 1 |
| Toivanen, J; Viinikka, L; Ylikorkala, O | 1 |
| Cerletti, C; de Gaetano, G; Lauri, D | 1 |
| Guccione, MA; O'Brien, KM; Packham, MA | 1 |
| Canciani, MT; Cattaneo, M; Mannucci, PM | 1 |
| Deykin, D; Jakubowski, JA; Stampfer, MJ; Vaillancourt, R | 1 |
| Atkinson, PM; Bradlow, BA; Chetty, N | 1 |
| Bernini, W; De Caterina, R; Donato, L; Filabozzi, P; Gazzetti, P; Giannessi, D; L'Abbate, A; Michelassi, C; Patrignani, P; Patrono, C | 1 |
| Gorczynska, E; James, M; Masiak, M; Wegrzynowicz, R | 1 |
| Catella, F; Ciabattoni, G; Davì, G; Filabozzi, P; Forni, L; Patrignani, P; Patrono, C; Pugliese, F | 1 |
| Colwell, JA; Halushka, PV; Mayfield, R | 1 |
| Boss, AH; Boysen, G; Olseen, JS | 1 |
| Eynard, AR; Galli, G; Maderna, P; Magni, F; Paoletti, R; Tremoli, E | 1 |
| Blair, IA; Ciabattoni, G; FitzGerald, GA; Patrono, C; Pierucci, A; Pugliese, F | 1 |
| Dietrich, M; Nawroth, PP; Stern, DM | 1 |
| Addonizio, VP; Fisher, CA; Harken, AH; Hirshfeld, JW; Laskey, WK; Martin, JL; Untereker, WJ | 1 |
| Bernini, W; De Caterina, R; Gazzetti, P; Giannessi, D | 1 |
| Cook, JA; Halushka, PV; Loadholt, CB; Reines, HD | 1 |
| Dusse, J; Stuart, MJ | 1 |
| Amado, JA; Richard, C; Sedano, MC; Suárez, M | 1 |
| Cerletti, C; de Gaetano, G; Dejana, E; Del Maschio, A; Galletti, F; Latini, R | 1 |
| Battaglia, D; Bernini, W; Boem, A; De Caterina, R; Dell'Amico, F; Giannessi, D; L'Abbate, A; Michelassi, C; Patrignani, P; Patrono, C | 1 |
| D'Angelo, A; Mannucci, PM; Pareti, FI; Smith, JB | 1 |
| Allen, PD; Dunham, B; Hechtman, HB; Krausz, MM; Mannick, JA; Shepro, D; Utsunomiya, T | 1 |
| Foegh, ML; Helfrich, GB; Ramwell, PW; Schreiner, GE; Winchester, JF; Zmudka, M | 1 |
| Born, GV; Shafi, S; Thorngren, M | 1 |
| Moncada, S; Salmon, JA; Simmons, PM | 1 |
| Buchanan, MR; Butt, R; Hirsh, J; Rischke, JA; Rosenfeld, J; Turpie, AG | 1 |
| Brash, AR; FitzGerald, GA; Lawson, JA; Maas, RL; Oates, JA; Roberts, LJ | 1 |
| Ciabattoni, G; Cinotti, GA; Filabozzi, P; Patrignani, P; Patrono, C; Pierucci, A; Pinca, E; Pugliese, F; Satta, MA; Simonetti, BM; van Dorne, D | 1 |
| Callow, AD; Connolly, RJ; Keough, EM; Mackey, WC; McCullough, JL; Melaragno, A; O'Donnell, TF; Ramberg-Laskaris, K; Valeri, CR; Weiblen, B | 1 |
| Kaplan, S; Marcoe, KF; Sauvage, LR; Wu, HD; Zammit, M | 1 |
| Barbieri, B; Bertelé, V; Bianchi, L; Cerletti, C; de Gaetano, G; Dejana, E; di Minno, G; Silver, MJ | 1 |
| Best, LC; Bone, EA; Graham, R; Russell, G | 1 |
| Mahmud, I; Miura, Y | 1 |
| Bianchine, J; Greenwald, JE; Metz, EN; Sagone, AL; Singh, D | 1 |
| Abbate, R; Galanti, G; Gensini, GF; Laureano, R; Neri Serheri, GG; Paoli, G | 1 |
| Borgeat, P; Picard, S; Roy, S; Sirois, P; Vallerand, P | 1 |
| Viinikka, L; Ylikorkala, O | 2 |
| Eldor, A; Levy, M; Polliack, G; Vlodavsky, I | 1 |
| Cromwell, M; Kaliman, J; Sinzinger, H | 1 |
| Kauppila, A; Viinikka, L; Ylikorkala, O | 1 |
| FitzGerald, GA; Oates, JA | 1 |
| Ritter, JM | 1 |
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| Berlin, I; Decroix, D; Herrmann, MA; Molinier, P; Peraudeau, P; Scheck, F | 1 |
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| Alessandri, C; Basili, S; Cipollone, F; Cordova, C; Davì, G; Gazzaniga, P; Santarone, S; Vieri, M; Violi, F | 1 |
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| Alberti, L; De Montis, MG; Franconi, F; Miceli, M; Seghieri, G; Tagliamonte, A | 1 |
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| Aoki, T; Honda, S; Okubo, M; Seki, J; Senzaki, K; Takahashi, F; Takasugi, H; Tanaka, A; Tomiyama, Y | 1 |
| Boylan, PC; Fitzgerald, DJ; FitzGerald, GA; McAdam, BF; McParland, P; Regan, CL | 1 |
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| Basili, S; Cordova, C; Fitzgerald, GA; Praticò, D; Vieri, M; Violi, F | 1 |
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| Beck, O; Fitzgerald, D; Granström, E; Harhen, B; Hjemdahl, P; Perneby, C | 1 |
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| Adderley, SR; Cunningham, AJ; Dowd, NP; Fitzgerald, DJ; Scully, M | 1 |
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| FitzGerald, GA; Hennekens, CH; Schror, K; Weisman, S | 1 |
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| Backman, JT; Kankuri, E; Karhunen, PJ; Lassila, R; Lepäntalo, A; Mikkelsson, J; Reséndiz, JC; Viiri, L | 1 |
| Kanazawa, S; Kinoshita, Y; Komiyama, Y; Muramatsu, M; Nomura, S; Yamaguchi, K | 1 |
| Fitzgerald, D; Hjemdahl, P; Perneby, C; Rooney, C; Wallén, NH | 1 |
| de Moerloose, P; Fontana, P; Nolli, S; Reber, G | 1 |
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| Becker, DM; Becker, LC; Bray, PF; Faraday, N; Herrera-Galeano, JE; Moy, TF; Segal, JB; Yanek, LR | 1 |
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| Flipo, RM | 1 |
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| Arima, J; Iguro, Y; Kariyazono, H; Masuda, H; Nakamura, K; Sakata, R; Yamada, K | 1 |
| Cagney, G; Coppinger, JA; Fitzgerald, DJ; Flanagan, M; Maguire, PB; O'Connor, R; Sullivan, M; Wynne, K | 1 |
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| Cox, D; Fitzgerald, DJ; Maree, AO | 1 |
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| Anzellotti, P; Capone, ML; Di Francesco, L; Di Gregorio, P; Merciaro, G; Patrignani, P; Sciulli, MG; Tacconelli, S | 1 |
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| Bliden, KP; Chaganti, SK; DiChiara, J; Etherington, A; Gesheff, T; Gurbel, PA; Neerchal, NK; Newcomer, J; Tantry, US; Weng, W | 1 |
| De La Cruz, JP; González-Correa, JA; Guerrero, A; López-Villodres, JA; Muñoz-Marín, J; Navas, MD; Torres, JA | 1 |
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| Fixler, DE; Heistein, LC; Journeycake, JM; Lemler, MS; Ramaciotti, C; Scott, WA; Zellers, TM | 1 |
| Ameln, W; Bjørnsen, S; Brosstad, F; Erikssen, G; Gjertsen, E; Khiabani, H; Lauritsen, ME; Meen, O; Ng, EC; Pedersen, TM; Schjelderup, NM; Siddique, SP; Wettergreen, M | 1 |
| Gu, Y; Lewis, DF; Wang, Y; Zhao, S | 1 |
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| Hartman, SJ; Jaffe, AS; Karon, BS; McConnell, JP; Santrach, PJ; Scott, R; Wockenfus, A | 1 |
| Davì, G; De Cristofaro, R; Dragani, A; Falco, A; Fioritoni, F; Lattanzio, S; Lessiani, G; Mattoscio, D; Recchiuti, A; Rocca, B; Romano, M; Santilli, F | 1 |
| Chen, KY; Gao, L; Li, YJ | 1 |
| Dobaczewski, M; Durackova, Z; Golanski, J; Kazmierczak, P; Kostka, B; Lapshina, E; Markuszewski, L; Nocun, M; Ulicna, O; Watala, C; Zavodnik, I; Zavodnik, L | 1 |
| Bergeron, AL; Delao, T; Dong, JF; Guthikonda, S; Kleiman, NS; Lev, EI; Mangalpally, K; Patel, R; Vaduganathan, M | 1 |
| McKeown, PP; McMullin, MF; Muir, AR; Patterson, C | 1 |
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| Asensi, R; Correa, JA; De La Cruz, JP; Espartero, JL; López-Villodres, JA; Rodríguez-Gutiérez, G | 1 |
| Choi, CI; Gao, L; Joseph, S; Kopelovich, L; Patlolla, JM; Rao, CV; Rigas, B; Steele, VE | 1 |
| Dukat, A; Kriska, M; Rajec, J; Risnyovszki, Z; Sapak, M; Vojtko, R | 1 |
| Bhatt, DL; Easton, JD; Eikelboom, JW; Fox, KA; Hamm, C; Hankey, GJ; Hu, T; Johnston, SC; Mak, KH; Montalescot, G; Steg, PG; Steinhubl, SR; Thom, J; Topol, EJ | 1 |
| Bauer, KS; Kapetanovic, IM; Lindeblad, MO; Lubet, R; Lyubimov, A; Tessier, DM; Zakharov, AD | 1 |
| Kankaanranta, H; Kerola, M; Kosonen, O; Moilanen, E; Sarna, S; Vuolteenaho, K | 1 |
| Hanayama, K; Hirashima, T; Imamura, F; Kanazawa, S; Kinoshita, Y; Nomura, S; Sasada, S; Siomi, K; Tujimoto, M; Yamaguchi, K | 1 |
| Ciabattoni, G; Davì, G; De Cristofaro, R; Ferrante, E; Habib, A; Lattanzio, S; Patrono, C; Pettinella, C; Pietrangelo, L; Recchiuti, A; Rocca, B; Santilli, F | 1 |
| Lev, EI | 1 |
| Davì, G; Liani, R; Pettinella, C; Romano, M; Santilli, F; Stuppia, L | 1 |
| Abderazek, F; Addad, F; Ben-Farhat, M; Chakroun, T; Dridi, Z; Elalamy, I; Gamra, H; Hamdi, S; Hassine, M; Samama, MM | 1 |
| Antonino, MJ; Bliden, KP; Coppolecchia, R; Gurbel, PA; Mahla, E; Tantry, US | 1 |
| de Metz, M; Huntjens-Fleuren, HW; Schuijt, MP; Vollaard, EJ | 1 |
| Eriksson, AC; Hedbäck, B; Jonasson, L; Lindahl, TL; Whiss, PA | 1 |
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| Blais, N; Diodati, JG; Lordkipanidzé, M; Merhi, Y; Pharand, C; Sia, YK | 1 |
| Drolet, M; Herzog, W; Karon, H; Mitchell, BD; Newcomer, S; Pakyz, R; Ryan, KA; Sack, P; Shen, H; Shi, X; Shuldiner, AR; Zhao, Y | 1 |
| Brune, K; Hochberg, MC; Oldenhof, J; Schiff, M | 1 |
| Angiolillo, DJ; Capodanno, D | 1 |
| Ciabattoni, G; Davì, G; Dragani, A; Ferrante, E; Habib, A; Lattanzio, S; Mattoscio, D; Mucci, L; Pascale, S; Patrono, C; Petrucci, G; Ranelletti, FO; Recchiuti, A; Rocca, B | 1 |
| Adhikari, CM; Gao, XR; Guo, XG; He, XY; Lin, J; Peng, LY; Zhai, YS; Zhang, LY; Zuo, ZY | 1 |
| Grove, EL; Hvas, AM; Kristensen, SD; Würtz, M | 1 |
| Carroll, RC; Craft, RM; Dakin, PA; Jarrett, A; Scott, J; Snider, CC; Wortham, DC; Worthington, RE | 1 |
| Armstrong, PC; Dhanji, AR; Mitchell, JA; Tucker, AT; Warner, TD | 1 |
| Barnard, MR; Christie, DJ; Fox, ML; Frelinger, AL; Furman, MI; Li, Y; Linden, MD; Michelson, AD | 1 |
| Jiang, D; Liu, H; Ou, B; Zhang, S | 1 |
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| Diodati, JG; Lordkipanidzé, M; Palisaitis, DA; Pharand, C; Schampaert, E | 1 |
| Samuelsson, K; Svensson, J | 1 |
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| De La Cruz, JP; Del Río, S; González-Correa, JA; Jebrouni, N; López-Villodres, JA; Villalobos, MA | 1 |
| Derhaschnig, U; Frossard, M; Fuchs, I; Jilma, B; Riedmüller, E; Spiel, AO | 1 |
| Brune, K; Hochberg, M; Oldenhof, J; Schiff, M | 1 |
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| Dong, JF; Guthikonda, S; Kleiman, NS; Mangalpally, KK; Siqueiros-Garcia, A; Vaduganathan, M | 1 |
| Alfieris, GM; Blumberg, N; Cholette, JM; Lerner, NB; Mamikonian, L | 1 |
| Cardona, F; Derhaschnig, U; Jilma, B; Marsik, C; Minuz, P; Schweeger-Exeli, I | 1 |
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| Grove, EL; Hvas, AM; Jensen, LO; Kaltoft, AK; Kristensen, SD; Tilsted, HH; Wulff, LN; Würtz, M | 1 |
| Grove, EL; Hvas, AM; Kristensen, SD; Larsen, SB; Mortensen, SB | 1 |
| Basselin, M; Chen, M; Ramadan, E; Rapoport, SI | 1 |
| De la Cruz, JP; Gonzalez-Correa, JA; Jebrouni, N; Lopez-Villodres, JA; Reyes, JJ; Ruiz-Moreno, MI | 1 |
| Cuccurullo, C; Davì, G; Di Iorio, P; Di Michele, D; Di Ruscio, P; Ferrante, E; Lattanzio, S; Laurora, G; Lessiani, G; Liani, R; Sgrò, G; Simeone, E; Vazzana, N | 1 |
| De Caterina, R; Malatesta, G; Renda, G; Ruggieri, B; Zurro, M | 1 |
| Gremmel, T; Kopp, CW; Koppensteiner, R; Panzer, S; Seidinger, D; Steiner, S | 1 |
| Guiso, M; Latina, V; Marra, C; Togna, AR; Togna, GI; Trefiletti, G | 1 |
| Anzellotti, P; Bruno, A; Capone, ML; Di Francesco, L; Di Gregorio, P; Garcia Rodriguez, LA; Grossi, L; Jeyam, A; Merciaro, G; Patrignani, P; Price, TS; Renda, G; Tacconelli, S; Tontodonati, P | 1 |
| Angiolillo, DJ; Bass, TA; Capodanno, D; Capranzano, P; Darlington, A; Desai, B; Dharmashankar, K; Ferreiro, JL; Kodali, M; Patel, A; Seecheran, N; Tello-Montoliu, A; Tomasello, SD; Ueno, M | 1 |
| Cherdon, C; de Leval, L; Defraigne, JO; Dogné, JM; Drion, P; Hanson, J; Masereel, B; Michiels, C; Ooms, A; Pirotte, B; Rolin, S; Sakalihassan, N | 1 |
| Akagi, Y; Aoyama, T; Nio, Y; Shimada, S | 1 |
| Cho, SH; Choi, BW; Choi, IS; Hong, CS; Jang, AS; Kim, MK; Kim, YH; Lee, JY; Lee, YM; Lee, YW; Oh, SH; Park, BL; Park, CS; Park, JS; Park, SM; Park, SW; Shin, HD; Uh, ST | 1 |
| Alves, MT; Bosco, AA; Carvalho, Md; Dusse, LM; Fernandes, AP; Freitas, FR; Gomes, KB; Gonçalves, LH; Komatsuzaki, F; Pianett, GA; Rodrigues, KF; Sóter, MO; Sousa, MO | 1 |
| Deev, AD; Dobrovol'skiĭ, AB; Katkova, OV; Laguta, PS; Panchenko, EP; Titaeva, EV | 1 |
| Adefurin, A; Ford, I; Greaves, M; Halawani, SH; Webster, J; Williams, DJ | 1 |
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| Huras, H; Jach, R; Musiał, J; Reroń, A; Rytlewski, K; Undas, A; Wilczak, M; Wójtowicz, A | 1 |
| Cosín-Sales, J; Dalli, E; Milara, J; Moscardó, A; Santos, MT; Sotillo, JF; Vallés, J | 1 |
| Gao, F; Men, JL; Ren, J; Wang, ZX; Wei, MX | 1 |
| Dworacki, G; Golanski, J; Kozubski, W; Kufel-Grabowska, J; Lukasik, M; Michalak, S; Watala, C | 1 |
| Arnetz, L; Brismar, K; Hjemdahl, P; Li, N; Östenson, CG; Spectre, G | 1 |
| Byron, JK; Hoh, CM; McMichael, MA; Smith, SA | 1 |
| Barbarulo, A; Felli, MP; Frati, L; Gaudio, C; Gazzaniga, P; Guerriero, R; Lotti, LV; Mattiello, T; Pucci, B; Pulcinelli, FM; Trifirò, E | 1 |
| Gruzdev, AK; Lomakin, NV | 1 |
| Angiolillo, DJ; Datto, C; Desai, B; Hwang, C; Sostek, M | 1 |
| Bähler, L; Gerdes, VE; Hoekstra, JB; Holleman, F; Kamphuisen, PW; Lemkes, BA; Nieuwland, R; Stroobants, AK; Van Den Dool, EJ | 1 |
| Eikelboom, JW; Hirsh, J; Johnston, MA; Li, C; Xie, C | 1 |
| Bednar, F; Kopa, M; Paluch, Z; Plasil, P; Prucha, M; Sadilkova, L; Tencer, T | 1 |
| Arieselia, Z; Baziad, A; Hartanto, MD; Setiabudy, R; Setiawati, A | 1 |
| Blakemore, D; Boutaud, O; Chen, Q; Haddad, EV; Oates, JA; Oram, D; Smith, JP; Taylor, MB | 1 |
| Al-Nadaf, S; Brainard, BM; Budsberg, SC; Cathcart, CJ; Reynolds, LR | 1 |
| Cefali, G; Gilmer, JF; Harmon, S; Jones, M; Kerins, DM; Ledwidge, MT; O'Connell, D; Ryan, F | 1 |
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| Amore, C; Dell'Elba, G; Di Santo, A; Evangelista, V; Martelli, N; Piccoli, A; Totani, L | 1 |
| Cardillo, C; Davì, G; Del Ponte, A; Ferrante, E; Ghirlanda, G; Lattanzio, S; Liani, R; Martini, F; Mattoscio, D; Mirabella, M; Morosetti, R; Mucci, L; Patrono, C; Petrucci, G; Pitocco, D; Rocca, B; Santilli, F; Vazzana, N; Vitacolonna, E; Zaccardi, F | 1 |
| Ames, PR; Batuca, JR; De La Torre, IG; Guyer, K; Lopez, LR; Matsuura, E; Muncy, IJ; Pascoe-Gonzales, S | 1 |
| Grove, EL; Hvas, AM; Kristensen, SD; Larsen, SB; Neergaard-Petersen, S | 1 |
| Bai, J; DeBeer, J; Eikelboom, JW; Hirsh, J; Johnston, MA; Li, C; Liang, Y; Paikin, J; Sloane, D | 1 |
| Andersson, T; Morrison, D; Nagy, P; Pisupati, J; Schettler, J; Warner, TD | 1 |
| Acconcia, MC; Barillà, F; Dominici, T; Gaudio, C; Mangieri, E; Paravati, V; Pellicano, M; Pulcinelli, FM; Tanzilli, G; Torromeo, C | 1 |
| Guyer, K; Inoue, K; Lopez, LR; Matsuura, E; Yamamoto, H | 1 |
| Ju, HK; Kwon, SW; Lee, CH; Lee, JG; Park, JH; Park, MK; Park, SJ | 1 |
| Hoshina, K; Manita, S; Matsuzawa, S; Miyata, Y; Ooie, T; Sasahara, T; Sueyoshi, S; Yasue, T | 1 |
| Chi, L; Han, Z; Lin, J; Yi, X; Zhou, Q | 1 |
| Kitagawa, Y; Suzuki, Y; Tokuoka, K; Watanabe, M; Yaguchi, T; Yamada, Y; Yokoyama, H | 1 |
| ElSafady, LA; Morad, AR; Sabri, NA; Salama, MM; Saleh, MA; Zaki, MM | 1 |
| Aligeti, VR; Carroll, RC; Craft, RM; Snider, CC; Wortham, DC | 1 |
| Grove, EL; Hvas, AM; Kristensen, SD; Larsen, SB | 1 |
| Dharmasaroja, PA; Muengtaweepongsa, S; Sae-Lim, S | 1 |
| Goodall, AH; Hayes, PD; Jones, CI; McMahon, GS; Naylor, AR | 1 |
| Czlonkowski, A; Filipiak, KJ; Grygorowicz, T; Janicki, PK; Kaplon-Cieslicka, A; Opolski, G; Postula, M; Przybylkowski, A; Rosiak, M; Trzepla, E | 1 |
| Duval, S; Hirsch, AT; Luepker, RV; Miller, K; Oldenburg, N; Zantek, ND | 1 |
| Gremmel, T; Kopp, CW; Koppensteiner, R; Panzer, S; Perkmann, T; Seidinger, D; Steiner, S | 1 |
| Curzen, N; Englyst, N; Radhakrishnan, A; Sambu, N; Weir, N | 1 |
| Blaha, CA; Drew, RC; Herr, MD; Mast, JL; Muller, MD; Sinoway, LI; Stocker, SD | 1 |
| Andrikopoulou, E; Blumenthal, RS; DeFilippis, AP; Fasoro, YA; Gerstenblith, G; Guallar, E; Jaffe, AS; Kickler, TS; Oloyede, OS; Palachuvattil, JM; Rade, JJ; Saenger, AK; Schulman, SP | 1 |
| Avalos, I; Chung, CP; Kawai, VK; Milne, GL; Oates, JA; Oeser, A; Solus, JF; Stein, CM | 1 |
| Filipiak, KJ; Kapłon-Cieślicka, A; Kondracka, A; Opolski, G; Postuła, M; Rosiak, M; Serafin, A | 1 |
| Chełstowski, K; Clark, J; Jastrzębska, M; Nowacki, P; Siennicka, A; Wódecka, A | 1 |
| Leuratti, C; Loprete, L; Radicioni, M; Scarsi, C | 1 |
| Bosco, AA; Carvalho, Md; Duarte, RC; Dusse, LM; Fernandes, AP; Gomes, KB; Gonçalves, LH; Silva, MV | 1 |
| Bolli, R; Cambon, A; DeFilippis, AP; Jaffe, AS; Jones, RO; Miles, RJ; Moser, AB; Rai, SN; Schulman, SP | 1 |
| Good, RI; Goodall, AH; James, TE; McConnachie, A; McGarrity, A; Miller, H; Oldroyd, KG; Sheehan, R; Stephens, J; Watkins, S | 1 |
| Binzen, U; Bugert, P; Greffrath, W; Maurer, K; Mörz, H; Schedel, A; Treede, RD | 1 |
| Christensen, KH; Grove, EL; Hvas, AM; Kristensen, SD; Würtz, M | 1 |
| Bliden, KP; Ens, G; Franzese, CJ; Gesheff, MG; Gurbel, PA; Guyer, K; Singh, M; Singla, A; Stapleton, D; Tabrizchi, A; Tantry, US; Toth, PP | 1 |
| Anand, SS; Chasman, DI; Connolly, SJ; Eikelboom, J; Eriksson, N; Gerstein, HC; Mehta, S; Paré, G; Ridker, PM; Rose, L; Ross, S; Wallentin, L; Yusuf, S | 1 |
| Del Boccio, P; Di Francesco, L; Dovizio, M; Guillem-Llobat, P; Lanas, A; Marcantoni, E; Patrignani, P; Patrono, C; Piazuelo, E; Sostres, C; Tacconelli, S; Zucchelli, M | 1 |
| Davì, G; Di Marco, M; Di Nicola, M; La Barba, S; Lattanzio, S; Liani, R; Mascellanti, M; Paloscia, L; Pascale, S; Santilli, F | 1 |
| Aukrust, P; Consoli, A; Davì, G; Di Fulvio, P; Formoso, G; Lattanzio, S; Liani, R; Santilli, F; Ueland, T; Vazzana, N | 1 |
| Arrivi, A; Barillà, F; Basili, S; Calvieri, C; Carnevale, R; Dominici, M; Farcomeni, A; Mangieri, E; Pignatelli, P; Placanica, A; Raparelli, V; Tanzilli, G; Violi, F | 1 |
| Becker, S; Campbell, J; Chen, N; Ferro, A; Floyd, CN; Goodman, T; Mustafa, A; Schofield, E; Sharma, P; Ward, M | 1 |
| Filipiak, KJ; Kaplon-Cieslicka, A; Kondracka, A; Opolski, G; Peller, M; Postula, M; Rosiak, M; Serafin, A; Trzepla, E | 1 |
| Bonten, TN; Eikenboom, J; Rosendaal, FR; Saris, A; Snoep, JD; van der Bom, JG; van der Meer, PF; van Oostrom, MJ; Zwaginga, J | 1 |
| Bertazzoni, G; Bucci, T; Calabrese, CM; Calvieri, C; Cangemi, R; Casciaro, M; Falcone, M; Farcomeni, A; Grieco, S; Palange, P; Pignatelli, P; Rossi, E; Taliani, G; Violi, F | 1 |
| Borhade, N; Burhan, A; Desai, DC; Dhiman, M; Gaikwad, P; Gund, M; Nemmani, KVS; Patil, M; Satyam, A; Sharma, A; Sharma, S; Sheikh, J; Thakre, G; Tipparam, SG | 1 |
| Chłopicki, S; Komar, M; Musiałek, P; Olszowska, M; Pajak, J; Podolec, J; Podolec, P; Rubis, P; Sitek, B; Tomkiewicz-Pajak, L; Wojcik, T | 1 |
| Chan, NC; Eikelboom, JW; Ginsberg, JS; Hirsh, J; Johnston, M; Paikin, JS; Pare, G; Weitz, JI; Whitlock, RP | 1 |
| Albisetti, M; Knirsch, W; Kretschmar, O; Kroiss, S; Rand, ML; Schmugge, M; Speer, O | 1 |
| Guarino, ML; Massimi, I; Montemari, AL; Pulcinelli, FM; Rina, A; Temperilli, F; Zicari, A | 1 |
| Good, RI; Goodall, AH; James, TE; McConnachie, A; McGarrity, A; Miller, H; Oldroyd, KG | 1 |
| Chuansumrit, A; Kadegasem, P; Sirachainan, N; Soisamrong, A; Wijarn, P; Wongwerawattanakoon, P | 1 |
| Hohlfeld, T; Kelm, M; Merx, MW; Polzin, A; Rassaf, T; Richter, S; Schrör, K; Zeus, T | 1 |
| Calver, AL; Corbett, S; Curzen, N; Dimitrov, BD; Englyst, N; Gray, H; Khanna, V; Mikael, R; Sambu, N; Simpson, IA; Thayalasamy, K; Wilkinson, JR | 1 |
| Holinstat, M; Reheman, A | 1 |
| Grove, EL; Hvas, AM; Kristensen, SD; Larsen, SB; Pareek, M | 1 |
| Grove, EL; Hvas, AM; Kristensen, SD; Larsen, SB; Neergaard-Petersen, S; Würtz, M | 1 |
| Choi, HI; Lee, JY; Sung, KC | 1 |
| Chen, X; Feng, X; Fu, SW; Liu, M; Liu, T; McCaffrey, TA; Zhang, J | 1 |
| Alusik, S; Burianova, I; Cybulja, A; Paluch, Z; Richter, T; Sadilkova, L | 1 |
| Brun, C; Combescure, C; Daali, Y; Fontana, P; Frelinger, AL; Michelson, AD; Reny, JL; Zufferey, A | 1 |
| Blaha, CA; Drew, RC; Herr, MD; Sinoway, LI; Stocker, SD | 1 |
| Bijak, M; Boryczka, K; Golanski, J; Golanski, R; Kaczmarski, J; Kuliczkowski, W; Watala, C | 1 |
| Gaspar, L; Klasic, A; Kruzliak, P; Lakusic, N | 1 |
| Bai, ZS; Chen, XH; Feng, XR; Liu, ML; Liu, TF; Zhang, JW | 1 |
| Balogh, L; Bereczky, Z; Édes, I; Haramura, G; Homoródi, N; Katona, É; Kiss, RG; Kovács, EG; Leé, S; Muszbek, L; Péterfy, H; Shemirani, AH; Szőke, G | 1 |
| Becerra, AZ; Block, R; Brenna, JT; Chalupa, D; Frampton, MW; Georas, S; Hopke, PK; Kane, C; Rich, DQ | 1 |
| Abumiya, T; Furui, E; Hattori, A; Hosomi, N; Isshiki, T; Kada, A; Kaikita, K; Kario, K; Katayama, Y; Kawamura, A; Kimura, K; Kitagawa, K; Minematsu, K; Miyata, S; Miyata, T; Nagao, T; Nagatsuka, K; Nakagawara, J; Nakane, H; Nishikawa, M; Ogawa, H; Okada, H; Saito, K; Takiuchi, S; Tanaka, K; Taomoto, K; Uchiyama, S; Wada, H; Yamawaki, T; Yonemoto, N | 1 |
| Didier, R; Galinat, H; Gilard, M; Gillet, B; Ianotto, JC; Lippert, E; Mingant, F; Ugo, V | 1 |
| Cai, YF; Chen, LY; Chen, XM; Huang, M; Jin, J; Li, JL; Peng, LL; Zhao, M; Zhao, YQ; Zhou, ZY | 1 |
| Berger, J; Diab, Y; Freishtat, R; Klugman, D; Patregnani, J; Sinha, P; Zurakowski, D | 1 |
| Bennett-Firmin, J; Bottiglieri, T; Lopez, LR; McCullough, PA; Peterson, M; Schiffmann, R; Swift, C; Vasudevan, A | 1 |
| Crosbie, L; Duttaroy, AK; Horgan, G; O'Kennedy, N; Song, HJ; Zhang, X | 1 |
| Cortina, B; Latorre, A; Moscardó, A; Santos, MT; Vallés, J | 1 |
| Ander, C; Dalén, M; Hjemdahl, P; Ivert, T; Lordkipanidzé, M; Näsman, P; Stålesen, R | 1 |
| Bennett-Firmin, J; Bottiglieri, T; Lopez, LR; McCullough, PA; Peterson, M; Sathyamoorthy, M; Schiffmann, R; Schussler, JM; Swift, C; Tecson, KM; Vasudevan, A; Velasco, CE | 1 |
| Backman, JD; Donnelly, P; Drolet, M; Horenstein, RB; Lewis, JP; Mitchell, BD; Morrisey, M; Newcomer, S; O'Connell, JR; Pavlovich, MA; Shaub, S; Tanner, K; Yerges-Armstrong, LM | 1 |
| Patrono, C; Rocca, B | 2 |
| Breitenstein, S; Erbel, R; Hohlfeld, T; Münzel, T; Pap, ÁF; Roitenberg, A; Trenk, D; Vom Dahl, J; Zahn, R; Zeymer, U | 1 |
| Chan, NC; Eikelboom, JW; Ginsberg, JS; Hirsh, J; Paikin, JS; Pare, G; Weitz, JI; Whitlock, RP | 1 |
| Ali Wasti, A; Carresi, C; Coluccio, M; Di Fabrizio, E; Fini, M; Gliozzi, M; Maiuolo, J; Malara, N; Mollace, R; Mollace, V; Muscoli, C; Musolino, V; Rosano, G; Silvestrini, B; Vitale, C | 1 |
| Gelbenegger, G; Heinz, G; Hobl, EL; Jilma, B; Lang, I; Reiter, B; Schoergenhofer, C; Schwameis, M; Speidl, WS; Staudinger, T; Zauner, C | 1 |
| Bliden, KP; Centofanti, R; Gurbel, PA; Jarvis, S; Tantry, US; Troullos, E; Venkataraman, P; Zhu, J | 1 |
| Caulfield, M; Fitzgerald, DJ; Ho, E; Howard, P; Hughes, AD; Johnson, T; McCarthy, NS; Munroe, PB; O'Brien, E; Rooney, C; Sever, P; Shields, DC; Stanton, AV; Surendran, P; Thom, S; Treumann, A; Vangjeli, C | 1 |
| Kou, N; Miao, Y; Qu, H; Shi, DZ; Wang, MM; Xue, M; Yang, B; Yang, L; Zang, MX | 1 |
| Brown, MD; Cook, MD; Grimm, H; Kretzschmar, J | 1 |
| Han, M; Han, N; Liu, Z; Lv, G; Song, Z; Yin, J; Yu, B; Zhou, J | 1 |
| Bao, L; Che, D; Deng, Q; Fang, Z; Gu, X; Li, J; Li, M; Li, W; Lin, S; Liu, T; Liu, Y; Long, H; Pi, L; Zhang, L; Zhang, Y | 1 |
| Beggiato, E; Bertozzi, I; Betti, S; Carli, G; Carpenedo, M; Cattaneo, D; Cavalca, V; De Stefano, V; Dragani, A; Elli, E; Finazzi, G; Iurlo, A; Lanzarone, G; Lissandrini, L; Palandri, F; Paoli, C; Patrono, C; Petrucci, G; Rambaldi, A; Ranalli, P; Randi, ML; Ricco, A; Rocca, B; Rodeghiero, F; Rossi, E; Ruggeri, M; Soldati, D; Specchia, G; Timillero, A; Tosetto, A; Turnu, L; Vannucchi, AM; Vianelli, N | 1 |
| Cao, J; Fan, L; Hao, WJ; Ke, SZ; Li, JH; Liu, L; Luo, XX; Sun, YF | 1 |
| Al-Sofiani, ME; Becker, DM; Becker, LC; Faraday, N; Kalyani, RR; Kral, BG; Mathias, R; Vaidya, D; Yanek, LR | 1 |
| Dannenberg, L; Helten, C; Hohlfeld, T; Kelm, M; Knoop, B; Naguib, D; Pöhl, M; Polzin, A; Schneider, T; Zeus, T | 1 |
| Bian, YY; Wang, LL; Yan, HY; Zou, CC | 1 |
| Chen, XH; Fu, SW; Liu, ML; Liu, WW; Wang, H | 1 |
| Angiolillo, DJ; Bhatt, DL; Cryer, B; Deliargyris, EN; Dong, JF; Jeske, W; Lanza, F; Marathi, U; Prats, J; von Chong, E; Zimmerman, RR | 1 |
| Bhatta, RS; Chhonker, YS; Dikshit, M; Kanuri, BN; Misra, A; Narain, VS; Negi, MPS; Pandey, CP | 1 |
| Bal Dit Sollier, C; Berge, N; Dautry, R; Dillinger, JG; Drouet, L; Gautier, JF; Henry, P; Paven, E; Riveline, JP; Vidal-Trecan, T | 1 |
| Abheiden, CNH; Arduç, A; Bij de Weg, JM; de Vries, JIP; Fuijkschot, WW; Mager, D; Smulders, YM; Thijs, A; van Diemen, JJK; Veraart, O | 1 |
| Barrett, TJ; Berger, JS; Eppler, M; Fisher, EA; Garshick, MS; Jelic, S; Krueger, JG; Lee, A; Mehta, NN; Neimann, AL; Salud-Gnilo, CM; Scher, JU; Tawil, M | 1 |
| Caldeira, D; Costa, J; Duarte, GS; Ferreira, J; Mainoli, B | 1 |
| Abdallah, IM; Ahmed, MS; Ali, M; AlSaud, AE; Danjuma, MI; Elshafei, MN; Imam, Y; Mohamed, MFH; Obeidat, K; Parray, AS; Saeid, R | 1 |
| Eichinger, S; Kaider, A; Kollars, M; Kyrle, PA; Siller-Matula, JM; Steinbrecher, O; Traby, L; Wolzt, M | 1 |
| Eichelberger, B; Gremmel, T; Kopp, CW; Lee, S; Panzer, S | 1 |
| Ambs, S; Baker, F; Cook, MB; Dorsey, TH; Kiely, M; Loffredo, CA; Milne, GL; Minas, TZ; Smith, CJ; Tang, W; Yates, C | 1 |
| Abdus, S; Bai, J; Eikelboom, JW; Gong, X; Gu, Q; Li, C; Lu, Y; Mei, L; Shi, L; Tan, C; Ullah, I; Wang, G; Yang, M; Ye, Z | 1 |
| Cheng, YQ; Guo, SF; Han, Y; Huo, YJ; Ke, J; Li, MT; Liu, AJ; Ma, J; Wu, Y; Zhang, L | 1 |
| Boucher, AA; Francisco, BJ; Luchtman-Jones, L; Martin, J; Martin, M; Nathan, JD; Pfeiffer, A; Shova, A; Tiao, GM | 1 |
| Chandra, SR; Christopher, R; Ramanujam, N; Sundaravadivel, P | 1 |
| Brodowski, J; Drozd, A; Kotlęga, D; Kozioł, I; Szczuko, M | 1 |
| Alfirevic, A; Francis, B; Gupta, JK; Lian, LY; Mcauliffe, FM; Meher, S; Mone, F; Mulcahy, C; Navaratnam, K; Phelan, MM; Zhang, E | 1 |
| Abdallah, IM; Abdelmoneim, MS; Akhtar, N; Ali, M; Alsaud, AE; Ayadathil, R; Chandra, P; Danjuma, MI; Elshafei, MN; Imam, Y; Mohamed, MFH; Mohammed, S; Obeidat, K; Parray, A; Saeid, R | 1 |
| Hutchinson, D; Kim, K; Kirkham, A; Kroencke, R; Munger, M; Nay, I; Rondina, M; Tolley, ND; Trujillo, T | 1 |
| Armitage, J; Aung, T; Bowman, L; Buck, G; Clark, S; Collins, R; Hill, MR; Mafham, M; Parish, S | 1 |
19 review(s) available for aspirin and thromboxane b2
| Article | Year |
|---|---|
The role of prostaglandins in platelet function.
Topics: Animals; Arteriosclerosis; Aspirin; Bleeding Time; Blood Platelets; Chemical Phenomena; Chemistry; Cyclic AMP; Epoprostenol; Haplorhini; Humans; Male; Platelet Aggregation; Prostaglandins; Thromboxane A2; Thromboxane B2; Thromboxanes | 1979 |
Thromboxane biosynthesis in cardiovascular diseases.
Topics: Aspirin; Cardiovascular Diseases; Humans; Platelet Activation; Risk Factors; Thromboxane A2; Thromboxane B2 | 1990 |
Clinical pharmacology of platelet cyclooxygenase inhibition.
Topics: Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Epoprostenol; Fibrinolytic Agents; Humans; Sulfinpyrazone; Sulindac; Thromboxane B2; Time Factors | 1985 |
Insulin and arachidonic acid metabolism in diabetes mellitus.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arthritis, Rheumatoid; Aspirin; Blood Platelets; Diabetes Mellitus; Epoprostenol; Humans; Insulin; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1985 |
Optimal dose for starting and maintaining low-dose aspirin.
Topics: Aspirin; Humans; Thrombosis; Thromboxane B2 | 1993 |
Characterization of biochemical and functional effects of antiplatelet drugs as a key to their clinical development.
Topics: Aspirin; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; Cyclooxygenase Inhibitors; Drug Design; Enzyme Inhibitors; Humans; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 1995 |
Monitoring the antiplatelet action of aspirin.
Topics: Aspirin; Dose-Response Relationship, Drug; Drug Monitoring; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane B2 | 2001 |
Aspirin resistance: definition, mechanisms and clinical read-outs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Clinical Trials as Topic; Drug Interactions; Drug Resistance; Humans; Models, Biological; Risk; Thrombosis; Thromboxane A2; Thromboxane B2; Time Factors | 2003 |
Terms and conditions: semantic complexity and aspirin resistance.
Topics: Aspirin; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Cyclooxygenase Inhibitors; Drug Interactions; Drug Resistance; Follow-Up Studies; Genetic Variation; Humans; Patient Compliance; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk; Thromboxane A2; Thromboxane B2; Treatment Failure | 2004 |
Pharmacodynamic interaction of naproxen with low-dose aspirin in healthy subjects.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Cardiovascular Diseases; Cyclooxygenase 1; Drug Interactions; Drug Therapy, Combination; Humans; In Vitro Techniques; Membrane Proteins; Naproxen; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 2005 |
A critical appraisal of the phenomenon of aspirin resistance.
Topics: Aspirin; Atherosclerosis; Cardiovascular Diseases; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Thromboxane A2; Thromboxane B2 | 2005 |
Can platelet function tests predict the clinical efficacy of aspirin?
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Clinical Trials as Topic; Drug Resistance; Flow Cytometry; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Thromboxane B2; Time Factors | 2005 |
[Are the NSAIDs able to compromising the cardio-preventive efficacy of aspirin?].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Cyclooxygenase Inhibitors; Drug Interactions; Follow-Up Studies; Humans; Ibuprofen; MEDLINE; Middle Aged; Multivariate Analysis; Naproxen; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk; Thromboxane B2; Ticlopidine; Time Factors | 2006 |
New mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications.
Topics: Acetylation; Aspirin; Cyclooxygenase Inhibitors; Humans; Lipoxins; Neutrophils; Randomized Controlled Trials as Topic; Sex Factors; Thromboxane B2 | 2006 |
Variable platelet response to aspirin and clopidogrel in atherothrombotic disease.
Topics: Adenosine Diphosphate; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Biomarkers; Biotransformation; Blood Coagulation Tests; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Interactions; Drug Resistance; Hemorrhage; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thrombosis; Thromboxane A2; Thromboxane B2; Ticlopidine; Treatment Failure | 2007 |
[Cyclooxygenase inhibitors and antiplatelet effect of acetylsalicylic acid. selective approach to nonsteroidal anti-inflammatory drugs in cardiological practice].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cardiovascular Diseases; Cardiovascular System; Cyclooxygenase 2 Inhibitors; Drug Interactions; Humans; Infusions, Parenteral; Platelet Activation; Platelet Aggregation Inhibitors; Risk Adjustment; Thromboxane B2 | 2011 |
Once- versus Twice-Daily Aspirin in Patients at High Risk of Thrombotic Events: Systematic Review and Meta-Analysis.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Administration Schedule; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis; Thromboxane B2 | 2021 |
The Role of Thromboxane in the Course and Treatment of Ischemic Stroke: Review.
Topics: Animals; Aspirin; Cardiovascular Diseases; Fibrinolytic Agents; Humans; Ischemic Stroke; Thromboxane B2 | 2021 |
Platelet response to aspirin in UK and Irish pregnancy cohorts: a genome-wide approach.
Topics: Aspirin; Cross-Sectional Studies; Female; Genome-Wide Association Study; Humans; Platelet Aggregation Inhibitors; Pregnancy; Prospective Studies; Thromboxane B2; United Kingdom | 2022 |
235 trial(s) available for aspirin and thromboxane b2
| Article | Year |
|---|---|
Importance of reperfusion on thromboxane A2 metabolite excretion after thrombolysis.
Topics: Aspirin; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Platelet Activation; Streptokinase; Thrombolytic Therapy; Thromboxane A2; Thromboxane B2; Tissue Plasminogen Activator | 1992 |
A randomized placebo-controlled study of the effect of low dose aspirin on platelet reactivity and serum thromboxane B2 production in non-pregnant women, in normal pregnancy, and in gestational hypertension.
Topics: Adult; Arachidonic Acid; Aspirin; Collagen; Female; Humans; Hypertension; Platelet Aggregation; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy Complications, Cardiovascular; Thromboxane B2 | 1992 |
Interaction study between Org 10172, a low molecular weight heparinoid, and acetylsalicylic acid in healthy male volunteers.
Topics: Adult; Aspirin; Blood Coagulation; Chondroitin Sulfates; Dermatan Sulfate; Drug Interactions; Factor Xa Inhibitors; Glycosaminoglycans; Hemostasis; Heparinoids; Heparitin Sulfate; Humans; Male; Platelet Aggregation; Thromboxane B2 | 1991 |
[Pharmacological correction by roxicam of the prostacyclin-thromboxane system in acute myocardial infarction complicated by heart failure].
Topics: 6-Ketoprostaglandin F1 alpha; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiac Glycosides; Diuretics; Epoprostenol; Heart Failure; Humans; Myocardial Infarction; Nitrates; Piroxicam; Thromboxane A2; Thromboxane B2; Thromboxanes | 1991 |
[Low-dose aspirin preventing pregnancy induced hypertension].
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Double-Blind Method; Female; Fibronectins; Humans; Pre-Eclampsia; Pregnancy; Prospective Studies; Thromboxane B2 | 1991 |
Two year Cottbus reinfarction study with 30 mg aspirin per day.
Topics: Aged; Aspirin; Dinoprost; Follow-Up Studies; Gastrointestinal Diseases; Germany; Hospitals, District; Humans; Middle Aged; Myocardial Infarction; Random Allocation; Recurrence; Survival Rate; Thromboxane B2 | 1991 |
Aspirin-induced gastric mucosal damage: prevention by enteric-coating and relation to prostaglandin synthesis.
Topics: Adult; Aspirin; Dinoprostone; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Male; Salicylates; Stomach Diseases; Tablets, Enteric-Coated; Thromboxane B2 | 1991 |
Combined aspirin and sulfinpyrazone in the prevention of recurrent hemodialysis vascular access thrombosis.
Topics: Aspirin; Blood Coagulation Tests; Blood Platelets; Catheters, Indwelling; Drug Evaluation; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Renal Dialysis; Sulfinpyrazone; Thrombosis; Thromboxane B2 | 1991 |
Coagulation, fibrinolytic and platelet function in patients on long-term therapy with aspirin 300 mg or 1,200 mg daily compared with placebo.
Topics: Aged; Aged, 80 and over; Aspirin; Bleeding Time; Blood Coagulation; Dose-Response Relationship, Drug; Female; Fibrinolysis; Fibrinopeptide A; Humans; Male; Middle Aged; Placebos; Plasminogen Activators; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Thromboembolism; Thromboxane B2; Time Factors | 1990 |
Long-term maintenance of thromboxane inhibition by two different aspirin regimens in patients with unstable angina.
Topics: Angina, Unstable; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Thromboxane B2; Thromboxanes | 1990 |
A study on the optimal dose of aspirin therapy in Kawasaki disease--clinical evaluation and arachidonic acid metabolism.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Chi-Square Distribution; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Mucocutaneous Lymph Node Syndrome; Prostaglandins F; Thromboxane B2 | 1990 |
Selective inhibition of platelet cyclooxygenase with controlled release, low-dose aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Blood Platelets; Delayed-Action Preparations; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 1990 |
R68070, a combined thromboxane/endoperoxide receptor antagonist and thromboxane synthase inhibitor, inhibits human platelet activation in vitro and in vivo: a comparison with aspirin.
Topics: Aspirin; Bleeding Time; Blood Platelets; Cyclic AMP; Dose-Response Relationship, Drug; Double-Blind Method; Humans; In Vitro Techniques; Pentanoic Acids; Phosphoproteins; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane B2; Thromboxane-A Synthase; Valerates | 1990 |
Effect of aspirin infusions on platelet function in humans.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Time Factors | 1990 |
Effects of nonsteroidal anti-inflammatory drugs on the bronchial hyperresponsiveness of middle-aged male smokers.
Topics: Aged; Airway Resistance; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bronchial Provocation Tests; Bronchoconstriction; Double-Blind Method; Flurbiprofen; Forced Expiratory Volume; Histamine; Humans; Male; Middle Aged; Smoking; Thromboxane B2 | 1990 |
Equivalent inhibition of in vivo platelet function by low dose and high dose aspirin treatment.
Topics: Aspirin; Blood Platelets; Creatinine; Humans; Thromboxane B2 | 1990 |
Dissociation of platelet activation and spontaneous myocardial ischemia in unstable angina.
Topics: Adolescent; Adult; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Coronary Circulation; Drug Therapy, Combination; Electrocardiography; Humans; Isosorbide; Middle Aged; Platelet Activation; Radioimmunoassay; Thromboxane B2 | 1990 |
Comparison of low-dose aspirin and coronary vasodilators in acute unstable angina.
Topics: Angina Pectoris; Angina, Unstable; Aspirin; Diltiazem; Drug Therapy, Combination; Electrocardiography; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Platelet Aggregation; Randomized Controlled Trials as Topic; Thromboxane A2; Thromboxane B2 | 1990 |
Response of thromboxane B2, malondialdehyde and platelet sensitivity to 3 weeks low-dose aspirin (ASA) in healthy volunteers.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Epoprostenol; Female; Humans; In Vitro Techniques; Male; Malonates; Malondialdehyde; Platelet Aggregation; Thromboxane B2 | 1989 |
Thromboxane biosynthesis in allergen-induced bronchospasm. Evidence for platelet activation.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Allergens; Aspirin; Blood Platelets; Bronchial Spasm; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Female; Forced Expiratory Volume; Gas Chromatography-Mass Spectrometry; Humans; Male; Placebos; Platelet Activation; Thromboxane A2; Thromboxane B2 | 1989 |
Differential effect of aspirin on thromboxane and prostaglandin biosynthesis in man.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Humans; Infusions, Intravenous; Injections; Male; Prostaglandins; Thromboxane B2; Thromboxanes | 1989 |
Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Epoprostenol; Female; Fetus; Humans; Hypertension; Pregnancy; Pregnancy Complications, Cardiovascular; Random Allocation; Thromboxane A2; Thromboxane B2; Thromboxanes | 1989 |
Acetylsalicylic acid 100 mg and 1000 mg daily in acute myocardial infarction suspects: a placebo-controlled trial.
Topics: Aspirin; Clinical Trials as Topic; Creatine Kinase; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Placebos; Platelet Aggregation; Random Allocation; Thromboxane B2 | 1989 |
Comparison of the effect of aspirin and choline magnesium trisalicylate on thromboxane biosynthesis in human platelets: role of the acetyl moiety.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bleeding Time; Blood Platelets; Choline; Double-Blind Method; Female; Humans; Male; Random Allocation; Salicylates; Thromboxane B2; Thromboxanes | 1989 |
Role of thromboxane A2 as a mediator of platelet-activating-factor-induced aggregation of human platelets.
Topics: Adult; Aspirin; Collagen; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Serotonin; Thromboxane A2; Thromboxane B2 | 1989 |
Low-dose aspirin in pregnancy.
Topics: Alprostadil; Apgar Score; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Ductus Arteriosus, Patent; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Platelet Aggregation; Pregnancy; Pregnancy Trimester, Third; Prospective Studies; Thromboxane B2 | 1989 |
Slow-release aspirin and prostaglandin inhibition.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Delayed-Action Preparations; Humans; Thromboxane B2 | 1986 |
Antiaggregative aspirin dosage at the affected vessel wall.
Topics: Aortic Arch Syndromes; Arm; Aspirin; Clinical Trials as Topic; Female; Humans; Platelet Aggregation; Random Allocation; Takayasu Arteritis; Thrombosis; Thromboxane B2 | 1986 |
Thromboxane receptor blockade versus cyclooxigenase inhibition: antiplatelet effects in patients.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angioplasty, Balloon; Arteriosclerosis; Aspirin; Bleeding Time; Blood Platelets; Clinical Trials as Topic; Collagen; Cyclooxygenase Inhibitors; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane B2; Thromboxanes | 1986 |
Effects of salicylic and acetylsalicylic acid alone and in combination on platelet aggregation and prostanoid synthesis in man.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Dinoprostone; Diuresis; Drug Interactions; Electrolytes; Humans; Platelet Aggregation; Prostaglandins; Prostaglandins E; Random Allocation; Salicylates; Thromboxane B2 | 1986 |
Effects of 1 gram oral or intravenous aspirin on urinary excretion of thromboxane B2 and 6-keto-PGF1 alpha in healthy subjects.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Adult; Aspirin; Biotransformation; Blood Platelets; Cyclooxygenase Inhibitors; Esterases; Humans; Injections, Intravenous; Kidney; Male; Thromboxane B2 | 1986 |
Inhibition of platelet function by low-dose plain and micro-encapsulated acetylsalicylic acid.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Bleeding Time; Blood Platelets; Double-Blind Method; Drug Compounding; Humans; Male; Platelet Aggregation; Platelet Function Tests; Tablets; Thromboxane B2 | 1988 |
Diminished platelet residence time on active human atherosclerotic lesions in-vivo--evidence for an optimal dose of aspirin?
Topics: Administration, Oral; Aged; Arteriosclerosis; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Male; Middle Aged; Thromboxane B2; Time Factors | 1988 |
Absence of differential inhibition of thromboxane A2 and prostacyclin by low and high dose aspirin in coronary artery disease.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aspirin; Coronary Disease; Electrocardiography; Epoprostenol; Humans; Lactates; Lactic Acid; Male; Middle Aged; Thromboxane A2; Thromboxane B2 | 1987 |
Gastroprotection by sucralfate against acetylsalicylic acid in humans. Role of endogenous prostaglandins.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Clinical Trials as Topic; Dinoprostone; DNA; Double-Blind Method; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Male; Prostaglandins; Prostaglandins E; Sucralfate; Thromboxane B2 | 1987 |
Dipyridamole preserved platelets and reduced blood loss after cardiopulmonary bypass.
Topics: Administration, Oral; Aspirin; Blood Platelets; Blood Transfusion; Cardiopulmonary Bypass; Dipyridamole; Erythrocyte Count; Female; Hemorrhage; Humans; Infusions, Intravenous; Leukocyte Count; Male; Middle Aged; Platelet Count; Platelet Factor 4; Postoperative Complications; Prospective Studies; Random Allocation; Thromboxane B2 | 1988 |
A dose-ranging study of the antiplatelet effect of enteric coated aspirin in man.
Topics: Adult; Aspirin; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation; Thrombosis; Thromboxane A2; Thromboxane B2 | 1987 |
Double blind controlled study on the effect of sucralfate on gastric prostaglandin formation and microbleeding in normal and aspirin treated man.
Topics: Adult; Aspirin; DNA; Double-Blind Method; Drug Evaluation; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Male; Prostaglandins; Sucralfate; Thromboxane B2 | 1986 |
Effect of preoperative antiplatelet drugs on vascular prostacyclin synthesis.
Topics: Aspirin; Blood Platelets; Blood Vessels; Coronary Disease; Dipyridamole; Drug Evaluation; Drug Therapy, Combination; Epoprostenol; Humans; Platelet Aggregation; Premedication; Thromboxane A2; Thromboxane B2 | 1987 |
Inhibition of prostacyclin and thromboxane A2 generation by low-dose aspirin at the site of plug formation in man in vivo.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Bleeding Time; Blood Platelets; Blood Vessels; Double-Blind Method; Epoprostenol; Hemostasis; Humans; Male; Thrombosis; Thromboxane A2; Thromboxane B2 | 1987 |
Effects of low doses of aspirin, 10 mg and 30 mg daily, on bleeding time, thromboxane production and 6-keto-PGF1 alpha excretion in healthy subjects.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Bleeding Time; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Function Tests; Thromboxane A2; Thromboxane B2; Thromboxanes; Time Factors | 1987 |
Coronary vasoconstrictor response to cold pressor test in variant angina: lack of relation to intracoronary thromboxane concentrations.
Topics: Adult; Angina Pectoris, Variant; Angiography; Aorta; Aspirin; Blood Pressure; Cold Temperature; Coronary Circulation; Hemodynamics; Humans; Male; Middle Aged; Osmolar Concentration; Thromboxane A2; Thromboxane B2; Vasoconstriction | 1987 |
Low-dose aspirin in patients recovering from myocardial infarction. Evidence for a selective inhibition of thromboxane-related platelet function.
Topics: Adult; Aged; Aspirin; Bleeding Time; Blood Platelets; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Infarction; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Thromboxane B2 | 1985 |
Estimated rate of thromboxane secretion into the circulation of normal humans.
Topics: Adult; Aspirin; Chromatography, Thin Layer; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Male; Metabolic Clearance Rate; Radioimmunoassay; Thromboxane B2 | 1986 |
Equal antiplatelet effects of aspirin 50 or 324 mg/day in patients after acute myocardial infarction.
Topics: Administration, Oral; Aged; Aspirin; Bleeding Time; Blood Platelets; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Myocardial Infarction; Partial Thromboplastin Time; Platelet Aggregation; Prothrombin Time; Thromboxane B2 | 1985 |
Platelets and the vessel wall: how much aspirin?
Topics: Adult; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Epoprostenol; Humans; Male; Platelet Aggregation; Thromboxane B2; Veins | 1980 |
Maintenance of cardiodynamics with aspirin during abdominal aortic aneurysmectomy (AAA).
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Triphosphatases; Aged; Aorta, Abdominal; Aortic Aneurysm; Aspirin; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Cardiac Output; Female; Humans; Intraoperative Care; Male; Middle Aged; Myocardial Contraction; Myocardium; Papillary Muscles; Premedication; Pulmonary Wedge Pressure; Thromboxane B2; Thromboxanes | 1981 |
Prostaglandins and endometriosis.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Clinical Trials as Topic; Endometriosis; Epoprostenol; Female; Humans; In Vitro Techniques; Indomethacin; ortho-Aminobenzoates; Prostaglandin Antagonists; Prostaglandins; Thromboxane A2; Thromboxane B2; Thromboxanes | 1983 |
[Venous prostacycline synthesis and plasma thromboxane B2 after low-dose aspirin].
Topics: Adult; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Endothelium; Epoprostenol; Humans; Leg; Middle Aged; Thromboxane B2; Veins | 1983 |
Prostacyclin and thromboxane in ovarian cancer: effect of cytostatics and prostaglandin synthesis inhibitors.
Topics: 6-Ketoprostaglandin F1 alpha; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Epoprostenol; Female; Humans; Indomethacin; Ovarian Neoplasms; Thromboxane A2; Thromboxane B2; Thromboxanes | 1983 |
Reduced side effects by low dose of acetylsalicylic acid (ASA) in patients with myocardial infarction; estimations of serum thromboxane B2 and PGF2 alpha.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Dinoprost; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Prostaglandins F; Thromboxane B2; Thromboxanes | 1984 |
Effect of acetylsalicylic acid on plasma thromboxane B2 and platelet aggregation in man.
Topics: Adult; Aspirin; Dose-Response Relationship, Drug; Humans; Male; Platelet Aggregation; Thromboembolism; Thromboxane B2; Thromboxanes | 1983 |
The effect of a thromboxane synthetase inhibitor, dazoxiben, and acetylsalicylic acid on platelet function and prostaglandin metabolism.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Aspirin; Blood Platelets; Humans; Imidazoles; Male; Middle Aged; Oxidoreductases; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins; Thromboxane B2; Thromboxane-A Synthase | 1983 |
The effect of acetylsalicylic acid in 3 different formulations on in vitro and in vivo platelet function tests. An experimental study on healthy male volunteers.
Topics: Adult; Aspirin; Bleeding Time; Blood Platelets; Delayed-Action Preparations; Dosage Forms; Humans; Male; Platelet Aggregation; Thromboxane B2 | 1984 |
Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials.
Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Arteries; Aspirin; Clinical Trials as Topic; Coronary Circulation; Coronary Vessels; Double-Blind Method; Female; Humans; Indomethacin; Ischemia; Male; Middle Aged; Recurrence; Thromboxane A2; Thromboxane B2; Thromboxanes; Time Factors; Veins | 1981 |
Prostacyclin, thromboxane and prostaglandin F2 alpha in suction blister fluid of human skin: effect of systemic aspirin and local glucocorticosteroid treatment.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Betamethasone; Blister; Clobetasol; Dinoprost; Epoprostenol; Exudates and Transudates; Humans; Male; Prostaglandins; Prostaglandins F; Skin; Thromboxane A2; Thromboxane B2; Thromboxanes | 1981 |
Aprotinin preserves hemostasis in aspirin-treated patients undergoing cardiopulmonary bypass.
Topics: Aprotinin; Aspirin; Blood Platelets; Cardiopulmonary Bypass; Double-Blind Method; Hemostasis; Hemostasis, Surgical; Humans; Middle Aged; Platelet Aggregation; Thromboxane B2 | 1994 |
Hemostatic function of aspirin-treated platelets vulnerable to cardiopulmonary bypass. Altered shear-induced pathway.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Coagulation Tests; Blood Loss, Surgical; Blood Platelets; Cardiopulmonary Bypass; Coronary Artery Bypass; Double-Blind Method; Hemostasis; Humans; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Thromboxane B2 | 1995 |
Maternal serum thromboxane B2 reduction versus pregnancy outcome in a low-dose aspirin trial.
Topics: Aspirin; Birth Weight; Double-Blind Method; Embryonic and Fetal Development; Female; Humans; Obstetric Labor, Premature; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Thromboxane B2 | 1995 |
Increased prostacyclin production during exercise in untrained and trained men: effect of low-dose aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Dinoprostone; Epoprostenol; Exercise; Gas Chromatography-Mass Spectrometry; Humans; Male; Physical Endurance; Physical Fitness; Platelet Aggregation; Thromboxane B2 | 1995 |
Aspirin therapy: optimized platelet inhibition with different loading and maintenance doses.
Topics: Administration, Oral; Adult; Analysis of Variance; Aspirin; Bleeding Time; Depression, Chemical; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Platelet Aggregation; Reference Values; Thromboxane B2; Time Factors | 1995 |
Pilot trial of the effects of low-dose acetylsalicylic acid on platelet thromboxane B2 production.
Topics: Adult; Aspirin; Blood Platelets; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Pilot Projects; Platelet Aggregation; Thromboxane B2 | 1995 |
Effects of unfractionated and low molecular weight heparins on platelet thromboxane biosynthesis "in vivo".
Topics: Adult; Aspirin; Blood Platelets; Evaluation Studies as Topic; Female; Heparin; Heparin, Low-Molecular-Weight; Humans; Male; Middle Aged; Thromboxane A2; Thromboxane B2 | 1994 |
Low dose aspirin: selective inhibition of rectal dialysis thromboxane B2 in healthy volunteers.
Topics: Adult; Aspirin; Blood Platelets; Cross-Over Studies; Dialysis; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Rectum; Thromboxane B2 | 1994 |
Effects of low-dose aspirin on in vitro platelet aggregation in the early minutes after ingestion in normal subjects.
Topics: Administration, Oral; Adult; Arachidonic Acid; Aspirin; Cross-Over Studies; Female; Humans; Longitudinal Studies; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Time Factors | 1994 |
Hemodynamic and humoral effects of low-dose aspirin in treated and untreated essential hypertensive patients.
Topics: Adult; Aldosterone; Aspirin; Captopril; Cross-Over Studies; Double-Blind Method; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Renin; Thromboxane B2 | 1994 |
Neonatal platelet reactivity and serum thromboxane B2 production in whole blood: the effect of maternal low dose aspirin.
Topics: Adult; Aspirin; Double-Blind Method; Female; Fetal Blood; Humans; Hypertension; In Vitro Techniques; Infant, Newborn; Platelet Aggregation; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Thromboxane B2 | 1994 |
[Improvement of prostacyclin-thromboxane A2 balance in patients with acute myocardial infarction by intermittent aspirin].
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Aged, 80 and over; Aspirin; Female; Humans; Male; Middle Aged; Myocardial Infarction; Thromboxane B2 | 1993 |
The effect of low-dose aspirin on fetal urine output and amniotic fluid volume.
Topics: Adult; Amniotic Fluid; Analysis of Variance; Aspirin; Chi-Square Distribution; Double-Blind Method; Female; Fetus; Gestational Age; Humans; Maternal-Fetal Exchange; Parity; Pregnancy; Regression Analysis; Thromboxane B2; Ultrasonography, Prenatal; Urinary Bladder; Urination | 1993 |
The effect of low-dose aspirin on umbilical artery Doppler measurements.
Topics: Aspirin; Blood Pressure; Double-Blind Method; Female; Fetus; Follow-Up Studies; Humans; Maternal-Fetal Exchange; Patient Compliance; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Regression Analysis; Rheology; Thromboxane B2; Ultrasonography, Prenatal; Umbilical Arteries; Vascular Resistance | 1993 |
Are pill counts valid measures of compliance in clinical obstetric trials?
Topics: Aspirin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Patient Compliance; Pre-Eclampsia; Pregnancy; Thromboxane B2 | 1993 |
[The effect of low dose aspirin on the platelet function in patients with acute myocardial infarction].
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Aspirin; Blood Platelets; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Function Tests; Thromboxane B2 | 1993 |
Dose effects of aspirin on gastric prostaglandins and stomach mucosal injury.
Topics: Adult; Aged; Aspirin; Dinoprost; Dinoprostone; DNA; Dose-Response Relationship, Drug; Female; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Hemoglobins; Humans; Male; Middle Aged; Prostaglandins; Reference Values; Thromboxane B2 | 1994 |
Effect of low-dose aspirin on thromboxane production and the antihypertensive effect of captopril.
Topics: Adult; Aspirin; Blood Platelets; Blood Pressure; Captopril; Double-Blind Method; Drug Interactions; Female; Humans; Hypertension; Kidney; Male; Middle Aged; Thromboxane B2; Thromboxanes | 1993 |
Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction. The Ridogrel Versus Aspir
Topics: Aged; Aspirin; Coronary Angiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Pentanoic Acids; Pyridines; Receptors, Prostaglandin; Receptors, Thromboxane; Thrombolytic Therapy; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Treatment Outcome; Vascular Patency | 1994 |
The effect of regular and enteric-coated aspirin on bleeding time, thromboxane, and prostacyclin.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Aspirin; Bleeding Time; Dosage Forms; Eicosanoids; Epoprostenol; Humans; Male; Middle Aged; Tablets, Enteric-Coated; Thromboxane A2; Thromboxane B2 | 1993 |
Aspirin, but not heparin, suppresses the transient increase in thromboxane biosynthesis associated with cardiac catheterization or coronary angioplasty.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiac Catheterization; Dose-Response Relationship, Drug; Female; Heparin; Humans; Male; Middle Aged; Models, Cardiovascular; Platelet Activation; Thromboxane A2; Thromboxane B2 | 1993 |
Low-dose aspirin therapy to prevent preeclampsia.
Topics: Adult; Aspirin; Eclampsia; Female; Humans; Hypertension; Parity; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Prospective Studies; Thromboxane B2 | 1993 |
Single-dose effect of enteric-coated aspirin on platelet function and thromboxane generation in middle-aged men.
Topics: Aged; Aspirin; Blood Platelets; Humans; Male; Middle Aged; Salicylates; Tablets, Enteric-Coated; Thromboxane B2 | 1993 |
The effectiveness of low dose slow release aspirin as an antiplatelet agent.
Topics: Adult; Aspirin; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 1993 |
The evolution of platelet aggregability in patients undergoing catheter ablation for supraventricular tachycardia with radiofrequency energy: the role of antiplatelet therapy.
Topics: Adenosine Diphosphate; Adult; Aorta; Aspirin; Catheter Ablation; Collagen; Electric Impedance; Female; Follow-Up Studies; Humans; Male; Monitoring, Intraoperative; Placebos; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Care; Pulmonary Artery; Tachycardia, Supraventricular; Temperature; Thromboxane B2; Time Factors | 1995 |
Influence of systemic cyclooxygenase inhibition with single-dose aspisol on kinetics of arachidonic acid metabolites in the venous effluate of transplanted kidney grafts in humans.
Topics: Adult; Arachidonic Acids; Aspirin; Creatinine; Cyclooxygenase Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Histocompatibility Testing; Humans; Kidney Transplantation; Leukotriene B4; Lysine; Male; Middle Aged; Prostaglandins F; Thromboxane B2 | 1996 |
[Effects of low dose aspirin on platelet function and prostaglandins metabolism in systemic and coronary circulation in patients with ischemia heart disease].
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Coronary Circulation; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Activation; Platelet Aggregation Inhibitors; Thromboxane B2 | 1995 |
[Low doses of acetylsalicylic acid effectively inhibits thrombocyte aggregation after ischemic stroke].
Topics: Aged; Aged, 80 and over; Aspirin; Blood Coagulation Tests; Brain Ischemia; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins F; Thromboxane A2; Thromboxane B2 | 1996 |
Effects of single oral doses of lysine clonixinate and acetylsalicylic acid on platelet functions in man.
Topics: Administration, Oral; Adult; Aspirin; Blood Platelets; Clonixin; Collagen; Cyclooxygenase Inhibitors; Dinoprost; Dose-Response Relationship, Drug; Humans; Lysine; Male; Platelet Aggregation; Thromboxane B2 | 1996 |
Modulation of oxidant stress in vivo in chronic cigarette smokers.
Topics: Administration, Cutaneous; Adolescent; Adult; Antioxidants; Ascorbic Acid; Aspirin; Cross-Sectional Studies; Dinoprost; Dose-Response Relationship, Drug; F2-Isoprostanes; Humans; Middle Aged; Nicotine; Oxidative Stress; Smoking; Thromboxane B2; Vitamin E | 1996 |
[Antiaggregant effect and tolerance of calcium carbasalate administrated immediately after aorto-coronary bypass. Results of a double-blind versus placebo study].
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Analgesics; Antithrombin III; Aspirin; beta-Thromboglobulin; Coronary Artery Bypass; Double-Blind Method; Drug Tolerance; Female; Fibrin Fibrinogen Degradation Products; Humans; Male; Malondialdehyde; Middle Aged; Platelet Aggregation; Postoperative Care; Thromboxane B2; Urea | 1996 |
Low-dose aspirin in polycythaemia vera: a pilot study. Gruppo Italiano Studio Policitemia (GISP).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Count; Polycythemia Vera; Thromboxane B2 | 1997 |
Diabetes mellitus, hypercholesterolemia, and hypertension but not vascular disease per se are associated with persistent platelet activation in vivo. Evidence derived from the study of peripheral arterial disease.
Topics: Adult; Aged; Aspirin; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Multivariate Analysis; Platelet Activation; Prospective Studies; Reproducibility of Results; Risk Factors; Smoking; Thromboxane A2; Thromboxane B2; Vascular Diseases | 1997 |
Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production.
Topics: Abortion, Habitual; Adult; Aspirin; Autoimmune Diseases; Blood Platelets; Epoprostenol; Female; Humans; Pregnancy; Thromboxane A2; Thromboxane B2 | 1997 |
Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina.
Topics: Aged; Angina, Unstable; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Isoenzymes; Isoindoles; Male; Membrane Proteins; Middle Aged; Phenylbutyrates; Prostaglandin-Endoperoxide Synthases; Reference Values; Thromboxane A2; Thromboxane B2 | 1997 |
[Comparison between effects of morning and evening administration of effervescent calcium carbasalate (equivalent of 160 mg aspirin) on the gastroduodenal mucosa in healthy volunteers].
Topics: Adult; Analgesics; Aspirin; Chronobiology Phenomena; Cross-Over Studies; Drug Tolerance; Duodenum; Female; Gastric Mucosa; Healthy Worker Effect; Humans; Intestinal Mucosa; Male; Platelet Aggregation; Salicylates; Thromboxane B2; Urea; Volunteers | 1997 |
Continued thromboxane A2 formation despite administration of a platelet glycoprotein IIb/IIIa antagonist in patients undergoing coronary angioplasty.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Biphenyl Compounds; Bleeding Time; Cell Division; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Fibrinogen; Heparin; Humans; Infusions, Intravenous; Male; Middle Aged; Muscle, Smooth, Vascular; P-Selectin; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyrrolidines; Thrombosis; Thromboxane A2; Thromboxane B2; Vasoconstriction | 1997 |
Thromboxane production in human lung during cardiopulmonary bypass: beneficial effect of aspirin?
Topics: Aged; Aged, 80 and over; Aspirin; Cardiopulmonary Bypass; Female; Humans; Lung; Male; Middle Aged; Thromboxane B2; Thromboxanes | 1998 |
Reduced fetal exposure to aspirin using a novel controlled-release preparation in normotensive and hypertensive pregnancies.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Cyclooxygenase Inhibitors; Delayed-Action Preparations; Double-Blind Method; Eicosanoids; Female; Fetal Blood; Humans; Pre-Eclampsia; Pregnancy; Thromboxane B2 | 1998 |
Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Endoscopy; Female; Humans; Knee Joint; Male; Middle Aged; Naproxen; Osteoarthritis; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrazoles; Safety; Severity of Illness Index; Stomach Ulcer; Sulfonamides; Thromboxane B2; Treatment Outcome | 1998 |
Maternal serum thromboxane B2 concentrations do not predict improved outcomes in high-risk pregnancies in a low-dose aspirin trial. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medical Units.
Topics: Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Osmolar Concentration; Predictive Value of Tests; Pregnancy; Pregnancy Outcome; Risk Factors; Thromboxane B2 | 1998 |
[Long term effects of 50 mg acetylsalicylic acid alone and in combination with dipyridamole on platelet function after coronary bypass surgery].
Topics: Anticoagulants; Aspirin; Blood Platelets; Coronary Artery Bypass; Coronary Disease; Dipyridamole; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Phenprocoumon; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Thromboxane B2; Time Factors | 1998 |
Effects of very low dose daily, long-term aspirin therapy on gastric, duodenal, and rectal prostaglandin levels and on mucosal injury in healthy humans.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Duodenum; Endoscopy, Digestive System; Female; Gastric Mucosa; Humans; Intestinal Mucosa; Male; Middle Aged; Prostaglandins; Rectum; Stomach; Thromboxane B2; Time Factors | 1999 |
Comparison of antiplatelet activity of microencapsulated aspirin 162.5 Mg (Caspac XL), with enteric coated aspirin 75 mg and 150 mg in patients with atherosclerosis.
Topics: Arteriosclerosis; Aspirin; Blood Platelets; Capsules; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Single-Blind Method; Thromboxane B2 | 1999 |
Administration of low-dose aspirin to mothers with small for gestational age fetuses and abnormal umbilical Doppler studies to increase birthweight: a randomised double-blind controlled trial.
Topics: Adult; Aspirin; Birth Weight; Double-Blind Method; Female; Fetal Growth Retardation; Humans; Platelet Aggregation Inhibitors; Pregnancy; Thromboxane B2; Ultrasonography, Doppler; Umbilical Cord | 1999 |
Increased thromboxane biosynthesis is associated with poststroke dementia.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Brain Ischemia; Cerebral Hemorrhage; Chronic Disease; Cognition; Creatinine; Dementia, Vascular; Female; Humans; Male; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Radioimmunoassay; Thromboxane A2; Thromboxane B2 | 1999 |
Aspirin absorption rates and platelet inhibition times with 325-mg buffered aspirin tablets (chewed or swallowed intact) and with buffered aspirin solution.
Topics: Absorption; Administration, Oral; Adult; Aspirin; Buffers; Chromatography, High Pressure Liquid; Citrates; Cross-Over Studies; Drug Combinations; Female; Follow-Up Studies; Humans; Male; Mastication; Middle Aged; Myocardial Infarction; Nonprescription Drugs; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Radioimmunoassay; Sodium Bicarbonate; Thromboxane B2 | 1999 |
Effect of aspirin on blood pressure in hypertensive patients taking enalapril or losartan.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aspirin; Blood Pressure; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Enalapril; Female; Humans; Hypertension; Losartan; Male; Middle Aged; Patient Compliance; Thromboxane B2 | 1999 |
Intravenous acetylsalicylic acid, magnesium and their combination in experimental arterial thrombosis in rats.
Topics: Animals; Arteriosclerosis; Aspirin; Blood Pressure; Double-Blind Method; Hemorrhage; Magnesium; Male; Rats; Rats, Wistar; Single-Blind Method; Thrombosis; Thromboxane B2 | 1999 |
Determinants of enhanced thromboxane biosynthesis in patients with systemic lupus erythematosus.
Topics: Adult; Antibodies, Antiphospholipid; Antigens; Aspirin; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Humans; Ischemia; Lupus Erythematosus, Systemic; Male; Middle Aged; Myocardial Infarction; Stroke; Thromboxane B2; Thromboxanes; Tissue Plasminogen Activator; Venous Thrombosis; von Willebrand Factor | 1999 |
Optimization of an enzyme immunoassay for 11-dehydro-thromboxane B(2) in urine: comparison with GC-MS.
Topics: Aspirin; Blood Platelets; Chromatography, Affinity; Evaluation Studies as Topic; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Immunoenzyme Techniques; Male; Reagent Kits, Diagnostic; Reference Values; Regression Analysis; Reproducibility of Results; Sensitivity and Specificity; Thromboxane B2; Time Factors; Urinalysis | 1999 |
40 mg of aspirin are not sufficient to inhibit platelet function under conditions of limited compliance.
Topics: Adult; Aspirin; Collagen; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Humans; Male; Patient Compliance; Platelet Aggregation; Thromboxane B2 | 2000 |
Monitoring of aspirin (ASA) pharmacodynamics with the platelet function analyzer PFA-100.
Topics: Adenosine Diphosphate; Adult; Antigens; Antigens, CD; Aspirin; Blood Coagulation Tests; Blood Platelets; Collagen; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Epinephrine; Female; Fibrinolytic Agents; Flow Cytometry; Genotype; Homozygote; Humans; Integrin alpha2; Longitudinal Studies; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Point Mutation; Prospective Studies; Thromboxane B2; Time Factors; von Willebrand Factor | 2000 |
Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Epoprostenol; F2-Isoprostanes; Female; Humans; Isoenzymes; Macrophages; Male; Membrane Proteins; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Thromboxane A2; Thromboxane B2 | 2000 |
A new cyclooxygenase-2 inhibitor, rofecoxib (VIOXX), did not alter the antiplatelet effects of low-dose aspirin in healthy volunteers.
Topics: Adolescent; Adult; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Female; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Sulfones; Thromboxane B2 | 2000 |
A comparison of every-third-day versus daily low-dose aspirin therapy on serum thromboxane concentrations in healthy men and women.
Topics: Adolescent; Adult; Aspirin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Thromboxane B2; Thromboxanes; Time Factors | 2001 |
Effects of low-dose aspirin on serum C-reactive protein and thromboxane B2 concentrations: a placebo-controlled study using a highly sensitive C-reactive protein assay.
Topics: Adult; Aspirin; C-Reactive Protein; Double-Blind Method; Female; Humans; Immunoassay; Male; Middle Aged; Prospective Studies; Thromboxane B2 | 2001 |
Effect of low-dose aspirin in combination with stable fish oil on whole blood production of eicosanoids.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Drug Interactions; Eicosanoids; Eicosapentaenoic Acid; Fish Oils; Humans; Leukotriene B4; Middle Aged; Thromboxane B2 | 2001 |
Oral glycoprotein IIb/IIIa antagonism in patients with coronary artery disease.
Topics: Administration, Oral; Adult; Aged; Aspirin; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Humans; Middle Aged; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombocytopenia; Thromboxane B2 | 2001 |
Comparison of the effects of ketoprofen on platelet function in the presence and absence of aspirin.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Delayed-Action Preparations; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; Ketoprofen; Male; Platelet Aggregation; Thromboxane B2 | 2001 |
Incomplete thromboxane inhibition with 100 mg of intravenous acetylsalicylic acid in patients with acute ST elevation myocardial infarction: a placebo-controlled pilot trial.
Topics: Aged; Aspirin; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Humans; Injections, Intravenous; Male; Middle Aged; Myocardial Infarction; Pilot Projects; Streptokinase; Thromboxane A2; Thromboxane B2; Thromboxanes | 2001 |
Urinary 11-dehydro-thromboxane B(2) and coagulation activation markers measured within 24 h of human acute ischemic stroke.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Aspirin; Biomarkers; Blood Coagulation; Brain Ischemia; Fibrinogen; Humans; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Stroke; Thromboxane B2 | 2001 |
Cyclooxygenase inhibitors and the antiplatelet effects of aspirin.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Drug Interactions; Drug Therapy, Combination; Humans; Ibuprofen; Isoenzymes; Lactones; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Sulfones; Thromboxane B2 | 2001 |
Aspirin and urinary 11-dehydrothromboxane B(2) in African American stroke patients.
Topics: Adult; Aged; Aspirin; Black People; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Stroke; Thromboxane B2 | 2002 |
Effects of enteric-coated, low-dose aspirin on parameters of platelet function.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Tablets, Enteric-Coated; Thromboxane B2 | 2002 |
Celecoxib does not affect the antiplatelet activity of aspirin in healthy volunteers.
Topics: Adenosine Diphosphate; Adolescent; Adult; Arachidonic Acid; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Female; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thromboxane B2 | 2002 |
Modulation of aspirin-insensitive eicosanoid biosynthesis by 6-methylprednisolone in unstable angina.
Topics: Adult; Angina, Unstable; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Double-Blind Method; Eicosanoids; Female; Glucocorticoids; Humans; Leukotriene E4; Male; Methylprednisolone; Middle Aged; Myocardial Ischemia; Thromboxane B2 | 2003 |
Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiotonic Agents; Digestive System; Double-Blind Method; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Intestinal Mucosa; Male; Pilot Projects; Placebos; Platelet Aggregation; Thromboxane B2 | 2003 |
Effects of cyclooxygenases inhibitors on vasoactive prostanoids and thrombin generation at the site of microvascular injury in healthy men.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bleeding Time; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Endothelium, Vascular; Fibrinolytic Agents; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Naproxen; Prostaglandin-Endoperoxide Synthases; Sulfones; Thrombin; Thromboxane B2 | 2003 |
Aspirin dosage and thromboxane synthesis in patients with vascular disease.
Topics: Aged; Aspirin; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation Inhibitors; Thromboxane B2; Thromboxanes; Vascular Diseases | 2003 |
Differences in the effects of extended-release aspirin and plain-formulated aspirin on prostanoids and nitric oxide in healthy volunteers.
Topics: Adult; Aspirin; Cross-Over Studies; Delayed-Action Preparations; Dinoprost; Double-Blind Method; Epoprostenol; Female; Humans; Male; Nitric Oxide; Platelet Aggregation Inhibitors; Salicylic Acid; Thromboxane B2 | 2003 |
Pharmacokinetic and pharmacodynamic differences between two low dosages of aspirin may affect therapeutic outcomes.
Topics: Adult; Area Under Curve; Aspirin; Blood Platelets; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Epoprostenol; Female; Fibrinolytic Agents; Humans; Male; Platelet Aggregation Inhibitors; Salicylates; Tablets, Enteric-Coated; Thromboxane B2; Treatment Outcome | 2003 |
Effects of diltiazem on platelet activation and cytosolic calcium during percutaneous transluminal coronary angioplasty.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Calcium; Calcium Channel Blockers; Coronary Thrombosis; Cytosol; Diltiazem; Drug Therapy, Combination; Female; Humans; Male; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thromboxane B2; Ticlopidine | 2003 |
Serial urinary 11-dehydrothromboxane B2, aspirin dose, and vascular events in blacks after recent cerebral infarction.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Black People; Cerebral Infarction; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Predictive Value of Tests; Recurrence; Risk Factors; Thromboxane B2; Ticlopidine | 2004 |
Reduction of daily life ischaemia by aspirin in patients with angina: underlying link between thromboxane A2 and macrophage colony stimulating factor.
Topics: Adult; Aged; Aspirin; Biomarkers; Cohort Studies; Coronary Artery Disease; Cross-Over Studies; Double-Blind Method; Electrocardiography, Ambulatory; Female; Humans; Interleukin-6; Macrophage Colony-Stimulating Factor; Male; Middle Aged; Myocardial Ischemia; Peptide Fragments; Platelet Aggregation Inhibitors; Prothrombin; Thromboxane A2; Thromboxane B2 | 2004 |
What is the lowest dose of aspirin for maximum suppression of in vivo thromboxane production after a transient ischemic attack or ischemic stroke?
Topics: Adult; Aged; Aspirin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Patient Compliance; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Thromboxane B2; Thromboxanes; Treatment Outcome | 2004 |
Clinical pharmacology of platelet, monocyte, and vascular cyclooxygenase inhibition by naproxen and low-dose aspirin in healthy subjects.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Cardiotonic Agents; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial Cells; Endothelium, Vascular; Female; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; Monocytes; Naproxen; Prostaglandin-Endoperoxide Synthases; Prostaglandins I; Thromboxane B2 | 2004 |
Meloxicam does not affect the antiplatelet effect of aspirin in healthy male and female volunteers.
Topics: Adult; Aspirin; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Interactions; Female; Humans; Isoenzymes; Male; Meloxicam; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Thiazines; Thiazoles; Thromboxane B2 | 2004 |
Short-term prevention of thromboembolic complications in patients with atrial fibrillation with aspirin plus clopidogrel: the Clopidogrel-Aspirin Atrial Fibrillation (CLAAF) pilot study.
Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Bleeding Time; Clopidogrel; Drug Therapy, Combination; Echocardiography, Transesophageal; Electric Countershock; Female; Humans; International Normalized Ratio; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Thromboembolism; Thromboxane B2; Ticlopidine; Warfarin | 2004 |
Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans.
Topics: Administration, Oral; Adult; Aspirin; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Duodenum; Flow Cytometry; Gastric Mucosa; Humans; Intestinal Mucosa; Male; Monocytes; Platelet Activation; Platelet Aggregation Inhibitors; Reference Values; Single-Blind Method; Stomach; Thromboxane A2; Thromboxane B2 | 2004 |
Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Female; Humans; Inflammation Mediators; Isoenzymes; Lipoxins; Male; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 2004 |
Prostacyclin, thromboxane A and the effect of low-dose ASA in pregnancies at high risk for hypertensive disorders.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Female; Humans; Hypertension, Pregnancy-Induced; Longitudinal Studies; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Pregnancy, High-Risk; Prostaglandins; Thromboxane A2; Thromboxane B2 | 2004 |
Platelet activation in patients with colorectal cancer.
Topics: Aged; Aspirin; Biomarkers; Colorectal Neoplasms; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Female; Humans; Male; Membrane Proteins; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 2005 |
Double-blind, randomized, parallel, placebo-controlled study of ibuprofen effects on thromboxane B2 concentrations in aspirin-treated healthy adult volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Double-Blind Method; Drug Antagonism; Female; Humans; Ibuprofen; Luminescent Measurements; Male; Middle Aged; Platelet Aggregation Inhibitors; Thromboxane B2 | 2005 |
Cigarette smoking is associated with increased circulating proinflammatory and procoagulant markers in patients with chronic coronary artery disease: effects of aspirin treatment.
Topics: Adult; Aged; Aspirin; C-Reactive Protein; Coronary Disease; Double-Blind Method; Female; Humans; Macrophage Colony-Stimulating Factor; Male; Middle Aged; Peptide Fragments; Prospective Studies; Prothrombin; Smoking; Thromboxane B2 | 2005 |
The influence of acetylsalicylic acid intake by healthy volunteers on duplicate PFA-100 measurements.
Topics: Adult; Aspirin; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Reproducibility of Results; Thromboxane B2 | 2005 |
Lumiracoxib does not affect the ex vivo antiplatelet aggregation activity of low-dose aspirin in healthy subjects.
Topics: Adolescent; Adult; Arachidonic Acid; Aspirin; Collagen; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Epoprostenol; Female; Humans; Male; Middle Aged; Organic Chemicals; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2005 |
Inhibition of thromboxane biosynthesis by triflusal in type 2 diabetes mellitus.
Topics: Adult; Aged; Aspirin; Biomarkers; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Radioimmunoassay; Retrospective Studies; Salicylates; Thromboxane B2; von Willebrand Factor | 2005 |
Aspirin has a gender-dependent impact on antiinflammatory 15-epi-lipoxin A4 formation: a randomized human trial.
Topics: Acetylation; Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Humans; Lipoxins; Middle Aged; Placebos; Sex Characteristics; Thromboxane B2 | 2006 |
Thromboxane-dependent CD40 ligand release in type 2 diabetes mellitus.
Topics: Aged; Aspirin; CD40 Ligand; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dinoprost; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Oxidative Stress; Platelet Activation; Platelet Aggregation Inhibitors; Radioimmunoassay; Thromboxane A2; Thromboxane B2 | 2006 |
Determinants of platelet activation in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspirin; Body Mass Index; C-Reactive Protein; Case-Control Studies; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Cyclooxygenase 2 Inhibitors; Dinoprost; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-6; Lactones; Logistic Models; Male; Odds Ratio; Platelet Activation; Radioimmunoassay; Sulfones; Thromboxane B2; Tumor Necrosis Factor-alpha; Vitamin E | 2007 |
Aspirin reduces adverse effects of gefitinib.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Carcinoma, Non-Small-Cell Lung; Drug Interactions; Female; Gefitinib; Humans; Lung Neoplasms; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Quinazolines; Thromboxane B2 | 2006 |
Biological effects of aspirin and clopidogrel in a randomized cross-over study in 96 healthy volunteers.
Topics: Adolescent; Adult; Aspirin; Blood Coagulation Tests; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thromboxane B2; Ticlopidine; Treatment Outcome | 2006 |
Aspirin resistance detected with aggregometry cannot be explained by cyclooxygenase activity: involvement of other signaling pathway(s) in cardiovascular events of aspirin-treated patients.
Topics: Aged; Aspirin; Blood Platelets; Cardiovascular Diseases; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Resistance; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Factors; Signal Transduction; Thromboxane B2; Treatment Outcome | 2006 |
Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers.
Topics: Adult; Aspirin; Aspirin, Dipyridamole Drug Combination; Body Weight; Cross-Over Studies; Dipyridamole; Dose-Response Relationship, Drug; Drug Combinations; Humans; Logistic Models; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Tablets, Enteric-Coated; Therapeutic Equivalency; Thromboxane B2; Treatment Outcome | 2006 |
Heterogeneity in the suppression of platelet cyclooxygenase-1 activity by aspirin in coronary heart disease.
Topics: Aged; Arachidonic Acid; Aspirin; Blood Platelets; Calcimycin; Coronary Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; Humans; Indans; Lipopolysaccharides; Male; Middle Aged; Neutrophils; Thromboxane A2; Thromboxane B2 | 2006 |
Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Celecoxib; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Ibuprofen; Male; Middle Aged; Myocardial Ischemia; Osteoarthritis; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Pyrazoles; Sulfonamides; Thromboxane B2; Treatment Outcome | 2006 |
Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity.
Topics: Adult; Asian People; Aspirin; Drug Resistance; Gene Frequency; Genotype; Humans; Japan; Male; Membrane Glycoproteins; Membrane Proteins; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Polymorphism, Single Nucleotide; Receptors, Thromboxane A2, Prostaglandin H2; Reference Values; Salicylic Acid; Thromboxane B2 | 2007 |
Effects of atorvastatin and aspirin combined therapy on inflammatory responses in patients undergoing coronary artery bypass grafting.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antithrombins; Aspirin; Atorvastatin; Blood Platelets; Cholesterol; Coronary Artery Bypass; Cytokines; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Inflammation; Male; Middle Aged; P-Selectin; Pyrroles; Receptors, Cytokine; Thrombin; Thromboxane B2; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2006 |
Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin.
Topics: Adenosine Diphosphate; Administration, Oral; Adult; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Resistance; Female; Flow Cytometry; Humans; Male; Membrane Proteins; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Reference Values; Tablets, Enteric-Coated; Thromboxane B2 | 2007 |
Human pharmacology of naproxen sodium.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Humans; Lipopolysaccharides; Monocytes; Naproxen; Platelet Aggregation; Thromboxane B2 | 2007 |
Variable platelet response to aspirin in patients with ischemic stroke.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Biological Availability; Blood Platelets; Brain Ischemia; Collagen; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Middle Aged; Patient Compliance; Platelet Aggregation; Platelet Aggregation Inhibitors; Stroke; Thromboxane B2; Treatment Outcome | 2007 |
Lack of aspirin-induced decrease in thrombin formation in subjects resistant to aspirin.
Topics: Aspirin; Bleeding Time; Blood Platelets; Cardiovascular Diseases; Dose-Response Relationship, Drug; Drug Resistance; Humans; Male; Microcirculation; Middle Aged; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Prothrombin; Risk Factors; Thrombin; Thromboxane B2 | 2007 |
Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Coronary Disease; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Female; Flow Cytometry; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Thrombelastography; Thromboxane B2 | 2007 |
Effects of selective cyclooxygenase isoform inhibition on systemic prostacyclin synthesis and on platelet function at rest and after exercise in healthy volunteers.
Topics: Adenosine Diphosphate; Adult; Aspirin; Atherosclerosis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Endothelium; Epoprostenol; Exercise; Humans; Isoenzymes; Lactones; Male; Platelet Activation; Rest; Risk Factors; Sulfones; Thrombosis; Thromboxane B2 | 2007 |
The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the aspirin-induced platelet effect (ASPECT) study.
Topics: Aged; Aspirin; Blood Platelets; Coronary Disease; Cross-Over Studies; Diabetic Angiopathies; Double-Blind Method; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Thromboxane B2 | 2007 |
No case of COX-1-related aspirin resistance found in 289 patients with symptoms of stable CHD remitted for coronary angiography.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Coronary Angiography; Coronary Disease; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Reference Values; Thromboxane B2 | 2008 |
Effect of aspirin on airway inflammation and pulmonary function in patients with persistent asthma.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Breath Tests; Bronchial Provocation Tests; Double-Blind Method; Female; Humans; Inflammation; Lipoxins; Lung; Male; Nitric Oxide; Placebos; Respiratory Function Tests; Thromboxane B2 | 2008 |
Platelet aggregation and recruitment with aspirin-clopidogrel therapy.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Stroke; Thromboxane B2; Ticlopidine | 2008 |
Aspirin responsiveness in healthy volunteers measured with multiple assay platforms.
Topics: Aspirin; Dose-Response Relationship, Drug; Drug Resistance; Humans; Immunoassay; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Thromboxane B2; Time Factors | 2008 |
[Effects of supplementing qi and activating blood circulation method on platelet aggregation rate, adhesion rate and thromboxane B2 level in patients with stable angina pectoris and intolerable to aspirin].
Topics: Aged; Angina Pectoris; Aspirin; Blood Circulation; Cell Adhesion; Drug Tolerance; Drugs, Chinese Herbal; Female; Humans; Male; Middle Aged; Platelet Aggregation; Qi; Thromboxane B2; Treatment Outcome | 2008 |
Increased platelet sensitivity among individuals with aspirin resistance - platelet aggregation to submaximal concentration of arachidonic acid predicts response to antiplatelet therapy.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Receptors, Thromboxane; Reference Values; Thromboxane B2; Treatment Failure | 2008 |
Comparison of oral aspirin versus topical applied methyl salicylate for platelet inhibition.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Area Under Curve; Aspirin; Cross-Over Studies; Double-Blind Method; Epinephrine; Humans; Immunoenzyme Techniques; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Salicylates; Statistics, Nonparametric; Thromboxane B2; Time Factors | 2008 |
Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid: determinants and effect on cardiovascular risk.
Topics: Aged; Aspirin; Cardiovascular Diseases; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Follow-Up Studies; Humans; Internationality; Male; Middle Aged; Risk Factors; Survival Rate; Thromboxane B2; Thromboxanes | 2008 |
Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Ibuprofen; Male; Nabumetone; Sulfonamides; Thromboxane B2 | 2009 |
Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: implications for aspirin "resistance".
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Resistance; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombopoietin; Thromboxane B2; Young Adult | 2009 |
Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin.
Topics: Administration, Oral; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Resistance; Female; Gene Frequency; Haplotypes; Heterozygote; Homozygote; Humans; Italy; Male; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Young Adult | 2009 |
Antiplatelet effects of aspirin with phytosterols: comparison with non-enteric coated aspirin alone.
Topics: Adolescent; Adult; Aspirin; Female; Humans; Male; Middle Aged; Phytosterols; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Young Adult | 2010 |
The interaction of ibuprofen and diclofenac with aspirin in healthy volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Delayed-Action Preparations; Diclofenac; Drug Interactions; Female; Humans; Ibuprofen; Male; Middle Aged; Platelet Aggregation; Risk Factors; Thromboxane B2 | 2009 |
Static platelet adhesion, flow cytometry and serum TXB2 levels for monitoring platelet inhibiting treatment with ASA and clopidogrel in coronary artery disease: a randomised cross-over study.
Topics: Aged; Aspirin; Case-Control Studies; Clopidogrel; Coronary Disease; Cross-Over Studies; Female; Fibrinogen; Flow Cytometry; Health; Humans; Male; Middle Aged; P-Selectin; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Principal Component Analysis; Regression Analysis; Thromboxane B2; Ticlopidine | 2009 |
Platelet inhibitory effects of OTC doses of naproxen sodium compared with prescription dose naproxen sodium and low-dose aspirin.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Naproxen; Nonprescription Drugs; Placebos; Platelet Aggregation Inhibitors; Reference Values; Thromboxane B2 | 2009 |
The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy.
Topics: Adult; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Etoricoxib; Female; Humans; Immunohistochemistry; Male; Middle Aged; Platelet Aggregation Inhibitors; Pyridines; Sulfones; Thrombocythemia, Essential; Thromboxane A2; Thromboxane B2; Thromboxanes; Treatment Outcome | 2010 |
Efficacy of different doses of aspirin in decreasing blood levels of inflammatory markers in patients with cardiovascular metabolic syndrome.
Topics: Adult; Aged; Anti-Inflammatory Agents; Aspirin; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Inflammation; Inflammation Mediators; Interleukin-6; Male; Metabolic Syndrome; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Thromboxane B2; Tumor Necrosis Factor-alpha | 2009 |
Reduction of platelet thromboxane A2 production ex vivo and in vivo by clopidogrel therapy.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Clopidogrel; Down-Regulation; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thromboxane A2; Thromboxane B2; Ticlopidine; Young Adult | 2010 |
Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Celecoxib; Drug Therapy, Combination; F2-Isoprostanes; Female; Humans; Male; Naproxen; Pyrazoles; Sulfonamides; Thromboxane B2; Treatment Outcome | 2010 |
Heterogeneity in platelet cyclooxygenase inhibition by aspirin in coronary artery disease.
Topics: Adult; Aspirin; Coronary Artery Disease; Cyclooxygenase Inhibitors; Female; Genetic Heterogeneity; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Thromboxane B2 | 2011 |
Platelet hyperfunction is decreased by additional aspirin loading in patients presenting with myocardial infarction on daily aspirin therapy.
Topics: Acute Coronary Syndrome; Aspirin; Cohort Studies; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Emergency Service, Hospital; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane B2 | 2010 |
Effect of maximum OTC doses of naproxen sodium or acetaminophen on low-dose aspirin inhibition of serum thromboxane B2.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Aspirin; Cyclooxygenase Inhibitors; Female; Humans; Male; Middle Aged; Naproxen; Nonprescription Drugs; Platelet Aggregation Inhibitors; Thromboxane B2; Young Adult | 2010 |
Effects of aspirin and NO-aspirin (NCX 4016) on platelet function and coagulation in human endotoxemia.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Coagulation; Blood Platelets; Double-Blind Method; Endotoxemia; Endotoxins; Humans; Male; Platelet Activation; Thromboxane B2; Young Adult | 2010 |
Effects of different doses, enteric-coated preparation of aspirin, and sex on urinary 11-dehydrothromboxane B2 in healthy volunteers.
Topics: Adult; Aspirin; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation Inhibitors; Sex Factors; Tablets, Enteric-Coated; Thromboxane B2; Time Factors | 2010 |
Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of iloprost.
Topics: Aged; Aged, 80 and over; Aspirin; Biomarkers; Blood Platelets; CD40 Ligand; Chi-Square Distribution; Critical Illness; Dinoprost; Drug Administration Schedule; Female; Humans; Iloprost; Inflammation Mediators; Infusions, Intravenous; Ischemia; Italy; Lipid Peroxidation; Male; Middle Aged; Nitric Oxide; Oxidative Stress; Platelet Activation; Platelet Aggregation Inhibitors; Thromboxane B2; Time Factors; Treatment Outcome | 2011 |
Low-dose naproxen interferes with the antiplatelet effects of aspirin in healthy subjects: recommendations to minimize the functional consequences.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Naproxen; Platelet Aggregation Inhibitors; Platelet-Rich Plasma; Reference Values; Thromboxane B2; Young Adult | 2011 |
Pharmacodynamic effects of different aspirin dosing regimens in type 2 diabetes mellitus patients with coronary artery disease.
Topics: Aged; Aspirin; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Thromboxane B2 | 2011 |
[Aspirin resistance in patients with stable ischemic heart disease].
Topics: Aged; Aspirin; Coronary Angiography; Drug Monitoring; Drug Resistance; Echocardiography, Transesophageal; Electrocardiography; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Activating Factor; Risk Factors; Severity of Illness Index; Thromboxane B2; Treatment Outcome | 2010 |
Effects of hawthorn (Crataegus laevigata) on platelet aggregation in healthy volunteers.
Topics: Adult; Analysis of Variance; Aspirin; Crataegus; Cross-Over Studies; Female; Fibrinolytic Agents; Flowers; Humans; Male; Plant Extracts; Plant Leaves; Platelet Aggregation; Platelet Aggregation Inhibitors; Spain; Thromboxane B2; Young Adult | 2011 |
Effect of polymorphism and type II diabetes on aspirin resistance in patients with unstable coronary artery disease.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Genotype; Humans; Male; Membrane Glycoproteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIb-IX Complex; Polymerase Chain Reaction; Polymorphism, Genetic; Receptors, Purinergic P2Y1; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane B2 | 2011 |
Aspirin treatment influences platelet-related inflammatory biomarkers in healthy individuals but not in acute stroke patients.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Case-Control Studies; CD40 Ligand; Cyclooxygenase 1; Female; Flow Cytometry; Humans; Inflammation; Male; Middle Aged; Monocytes; P-Selectin; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Stroke; Thromboxane B2 | 2011 |
Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications.
Topics: Aspirin; Blood Platelets; Cells, Cultured; Clinical Protocols; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Dosage Calculations; Humans; Microvessels; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2011 |
Impact of a fixed-dose combination of naproxen and esomeprazole magnesium on serum thromboxane B2 inhibition by low-dose aspirin over 5 days in healthy adults: a phase I, randomized, double-blind, placebo-controlled, noninferiority trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Combinations; Esomeprazole; Female; Humans; Male; Middle Aged; Naproxen; Pilot Projects; Placebos; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Tablets, Enteric-Coated; Thromboxane B2; Time Factors; United States | 2011 |
The influence of aspirin dose and glycemic control on platelet inhibition in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Aspirin; Biomarkers; Blood Platelets; Cardiovascular Diseases; Chi-Square Distribution; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Middle Aged; Multivariate Analysis; Netherlands; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Regression Analysis; Thromboxane B2; Treatment Outcome | 2012 |
Reversal of the anti-platelet effects of aspirin and clopidogrel.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Biomarkers; Blood Platelets; Clopidogrel; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Ontario; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Transfusion; Recovery of Function; Thromboxane B2; Ticlopidine; Time Factors | 2012 |
Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome.
Topics: Aged; Aspirin; Blood Platelets; Cardiovascular Diseases; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Gas Chromatography-Mass Spectrometry; Humans; Male; Metabolic Syndrome; Middle Aged; Platelet Aggregation; Prospective Studies; Thromboxane B2; Treatment Outcome | 2012 |
Lack of inhibitory effect of acetylsalicylic acid and meloxicam on whole blood platelet aggregation in cats.
Topics: Animals; Aspirin; Cats; Cross-Over Studies; Male; Meloxicam; Platelet Aggregation; Thiazines; Thiazoles; Thromboxane B2 | 2012 |
The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes.
Topics: Aged; Aspirin; Blood Platelets; Case-Control Studies; Cyclooxygenase 1; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Male; Thromboxane B2 | 2012 |
Aspirin insensitive thromboxane generation is associated with oxidative stress in type 2 diabetes mellitus.
Topics: Administration, Oral; Antioxidants; Aspirin; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Oxidative Stress; Thromboxane B2 | 2012 |
Aspirin response variability after major orthopedic surgery.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Aspirin; Blood Platelets; Cohort Studies; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; Thromboxane B2 | 2012 |
Evaluation of the pharmacodynamics of acetylsalicylic acid 81 mg with or without esomeprazole 20 mg in healthy volunteers.
Topics: Adolescent; Adult; Aged; Aspirin; Cross-Over Studies; Drug Interactions; Esomeprazole; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Thromboxane B2; Young Adult | 2012 |
Clopidogrel plus indobufen in acute coronary syndrome patients with hypersensitivity to aspirin undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Drug Hypersensitivity; Drug Therapy, Combination; Female; Humans; Isoindoles; Male; Middle Aged; Percutaneous Coronary Intervention; Phenylbutyrates; Platelet Aggregation Inhibitors; Risk Factors; Thromboxane B2; Ticlopidine; Treatment Outcome | 2013 |
Resistance to low-dose aspirin therapy among patients with acute coronary syndrome in relation to associated risk factors.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aspirin; Collagen; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Factors; Thromboxane B2 | 2012 |
Transient heparin-induced platelet activation linked to generation of platelet 12-lipoxygenase. Findings from a randomised controlled trial.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adenosine Diphosphate; Aged; Arachidonate 12-Lipoxygenase; Aspirin; Blood Platelets; Dalteparin; Endarterectomy, Carotid; Female; Gene Expression Regulation, Enzymologic; Heparin; Humans; Lipase; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Thromboxane B2 | 2013 |
Thromboxane A(2) generation, in the absence of platelet COX-1 activity, in patients with and without atherothrombotic myocardial infarction.
Topics: Aged; Aspirin; Blood Platelets; Coronary Artery Disease; Creatinine; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Thrombosis; Thromboxane A2; Thromboxane B2 | 2013 |
Suboptimal inhibition of platelet cyclooxygenase 1 by aspirin in systemic lupus erythematosus: association with metabolic syndrome.
Topics: Adult; Aspirin; Biomarkers; Blood Platelets; C-Reactive Protein; Chi-Square Distribution; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Female; Humans; Lupus Erythematosus, Systemic; Male; Metabolic Syndrome; Middle Aged; Obesity; Prospective Studies; Thromboxane B2; Time Factors; Treatment Outcome | 2014 |
Predictors of high platelet reactivity during aspirin treatment in patients with type 2 diabetes.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Biomarkers; Blood Platelet Disorders; Blood Platelets; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Logistic Models; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Thromboxane B2 | 2013 |
Pharmacodynamics and pharmacokinetics of a novel, low-dose, soft-gel capsule of acetylsalicylic acid in comparison with an oral solution after single-dose administration to healthy volunteers: a phase I, two-way crossover study.
Topics: Administration, Oral; Adult; Aspirin; Capsules; Cross-Over Studies; Female; Healthy Volunteers; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Solutions; Therapeutic Equivalency; Thromboxane B2; Young Adult | 2014 |
Acetylsalicylic acid therapy: influence of metformin use and other variables on urinary 11-dehydrothromboxane B2 levels.
Topics: Aspirin; Biological Transport; Diabetes Mellitus, Type 2; Female; Glucose; Humans; Hypoglycemic Agents; Insulin Resistance; Intestinal Absorption; Male; Metformin; Middle Aged; Oxidative Stress; Risk Factors; Thromboxane B2 | 2014 |
Reappraisal of the clinical pharmacology of low-dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action.
Topics: Acetylation; Area Under Curve; Aspirin; Biomarkers; Cyclooxygenase 1; Dose-Response Relationship, Drug; Thromboxane B2 | 2014 |
Aspirin reload before elective percutaneous coronary intervention: impact on serum thromboxane b2 and myocardial reperfusion indexes.
Topics: Aged; Aspirin; Female; Humans; Male; Microvessels; Middle Aged; Myocardial Reperfusion Injury; Percutaneous Coronary Intervention; Postoperative Complications; Preoperative Period; Thrombosis; Thromboxane B2; Treatment Outcome; Troponin I | 2014 |
Younger age, higher body mass index and lower adiponectin concentration predict higher serum thromboxane B2 level in aspirin-treated patients with type 2 diabetes: an observational study.
Topics: Adiponectin; Age Factors; Aged; Aspirin; Biomarkers; Body Mass Index; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Thromboxane B2; Treatment Outcome | 2014 |
Effect of aspirin intake at bedtime versus on awakening on circadian rhythm of platelet reactivity. A randomised cross-over trial.
Topics: Aspirin; Biomarkers; Blood Platelets; Circadian Rhythm; Cross-Over Studies; Cyclooxygenase 1; Drug Administration Schedule; Female; Healthy Volunteers; Humans; Male; Netherlands; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Thromboxane B2; Time Factors; Treatment Outcome; Young Adult | 2014 |
Platelet activation is associated with myocardial infarction in patients with pneumonia.
Topics: Aged; Aspirin; Biomarkers; CD40 Ligand; Community-Acquired Infections; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Pneumonia; Prognosis; Prospective Studies; Thromboxane B2; Troponin T | 2014 |
Multiple daily doses of acetyl-salicylic acid (ASA) overcome reduced platelet response to once-daily ASA after coronary artery bypass graft surgery: a pilot randomized controlled trial.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Coronary Artery Bypass; Drug Administration Schedule; Drug Resistance; Female; Humans; Male; Middle Aged; Ontario; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Thromboxane B2; Time Factors; Treatment Outcome | 2015 |
Prevention of dipyrone (metamizole) induced inhibition of aspirin antiplatelet effects.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Aspirin; Biomarkers; Blood Platelets; Chromatography, High Pressure Liquid; Coronary Artery Disease; Cross-Over Studies; Dipyrone; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Thromboxane B2 | 2015 |
Healthy older humans exhibit augmented carotid-cardiac baroreflex sensitivity with aspirin during muscle mechanoreflex and metaboreflex activation.
Topics: 6-Ketoprostaglandin F1 alpha; Age Factors; Aspirin; Baroreflex; Blood Pressure; Chemoreceptor Cells; Cyclooxygenase Inhibitors; Female; Healthy Volunteers; Heart Rate; Humans; Lower Extremity; Male; Mechanoreceptors; Mechanotransduction, Cellular; Middle Aged; Muscle Contraction; Muscle, Skeletal; Thromboxane B2 | 2015 |
High on Aspirin Platelet Reactivity in Pediatric Patients Undergoing the Fontan Procedure.
Topics: Aspirin; Blood Platelets; Child, Preschool; Female; Fontan Procedure; Humans; Male; Platelet Activation; Thrombelastography; Thromboxane B2 | 2016 |
A randomised controlled trial comparing a dietary antiplatelet, the water-soluble tomato extract Fruitflow, with 75 mg aspirin in healthy subjects.
Topics: Aged; Arachidonic Acid; Aspirin; Blood Platelets; Cross-Over Studies; Diet; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Plant Extracts; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Solanum lycopersicum; Thromboxane B2 | 2017 |
Platelet function one and three months after coronary bypass surgery in relation to once or twice daily dosing of acetylsalicylic acid.
Topics: Aged; Aspirin; Blood Platelets; Coronary Artery Bypass; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Thrombosis; Thromboxane B2 | 2017 |
Prospective, randomised trial of the time dependent antiplatelet effects of 500 mg and 250 mg acetylsalicylic acid i. v. and 300 mg p. o. in ACS (ACUTE).
Topics: Acute Coronary Syndrome; Administration, Intravenous; Administration, Oral; Adult; Aged; Aspirin; Biomarkers; Blood Platelets; Drug Monitoring; Female; Germany; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Factors; Thromboxane B2; Time Factors; Treatment Outcome | 2017 |
Once versus twice daily aspirin after coronary bypass surgery: a randomized trial.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Coronary Artery Bypass; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Ontario; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane B2; Time Factors; Treatment Outcome | 2017 |
Aspirin wears smart.
Topics: Administration, Sublingual; Animals; Aspirin; Biomarkers; Collagen; Double-Blind Method; Drug Compounding; Fibrinolytic Agents; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Rats; Thromboxane B2 | 2017 |
Acetylsalicylic acid in critically ill patients: a cross-sectional and a randomized trial.
Topics: Administration, Oral; Aged; Analysis of Variance; Aspirin; Critical Illness; Cross-Sectional Studies; Female; Humans; Infusions, Intravenous; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2017 |
Thromboxane inhibition during concurrent therapy with low-dose aspirin and over-the-counter naproxen sodium.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Middle Aged; Naproxen; Platelet Aggregation Inhibitors; Thromboxane B2; Thromboxanes | 2018 |
The Aspirin Regimens in Essential Thrombocythemia (ARES) phase II randomized trial design: Implementation of the serum thromboxane B
Topics: Aspirin; Biomarkers; Clinical Protocols; Disease Management; Female; Humans; Male; Patient Selection; Platelet Aggregation Inhibitors; Research Design; Thrombocythemia, Essential; Thrombosis; Thromboxane B2 | 2018 |
Pharmacokinetic/pharmacodynamic assessment of a novel, pharmaceutical lipid-aspirin complex: results of a randomized, crossover, bioequivalence study.
Topics: Adult; Aspirin; Cross-Over Studies; Drug Carriers; Gastrointestinal Tract; Humans; Lipids; Middle Aged; Mucous Membrane; Therapeutic Equivalency; Thromboxane B2; Young Adult | 2019 |
Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis via COX-1.
Topics: Adult; Aspirin; Blood Platelets; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Endothelial Cells; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Adhesiveness; Psoriasis; Severity of Illness Index; Signal Transduction; Thromboxane B2; Treatment Outcome | 2020 |
An investigation into the impact of enteric coated of aspirin in patients with newly diagnosed ischemic stroke (ECASIS).
Topics: Adolescent; Adult; Aged; Aspirin; Blood Platelets; Brain Ischemia; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Single-Blind Method; Socioeconomic Factors; Stroke; Tablets, Enteric-Coated; Thromboxane B2; Young Adult | 2020 |
Differential Effects of Clopidogrel With or Without Aspirin on Platelet Reactivity and Coagulation Activation: A Randomized Trial in Healthy Volunteers.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; beta-Thromboglobulin; Blood Coagulation; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Drug Therapy, Combination; Healthy Volunteers; Humans; Male; Microfilament Proteins; P-Selectin; Phosphoproteins; Platelet Aggregation Inhibitors; Thromboxane B2; Whole Blood Coagulation Time; Young Adult | 2021 |
Pharmacodynamic effects of indobufen compared with aspirin in patients with coronary atherosclerosis.
Topics: Aged; Aspirin; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Isoindoles; Male; Middle Aged; Phenylbutyrates; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2021 |
Prospective, randomized, controlled, trial to assess ASA DOSing by body mass index in HEalthy volunteers (DOSE study).
Topics: Adult; Aspirin; Body Mass Index; Cardiovascular Diseases; Female; Healthy Volunteers; Humans; Male; Middle Aged; Obesity; Platelet Aggregation Inhibitors; Prospective Studies; Thromboxane B2; Young Adult | 2023 |
Effect of low-dose aspirin on urinary 11-dehydro-thromboxane B2 in the ASCEND (A Study of Cardiovascular Events iN Diabetes) randomized controlled trial.
Topics: Aspirin; Cardiovascular Diseases; Diabetes Mellitus; Humans; Thromboxane B2 | 2023 |
574 other study(ies) available for aspirin and thromboxane b2
| Article | Year |
|---|---|
A method for measurement of platelet regeneration in man.
Topics: Aspirin; Blood Platelets; Humans; In Vitro Techniques; Methods; Prostaglandin-Endoperoxide Synthases; Regeneration; Thromboxane B2; Time Factors | 1978 |
Effect of inhibitors of arachidonic acid metabolism on mitogenesis in human lymphocytes: possible role of thromboxanes and products of the lipoxygenase pathway.
Topics: Antilymphocyte Serum; Arachidonic Acids; Aspirin; Concanavalin A; Fatty Acids, Unsaturated; Humans; Lipids; Lipoxygenase; Lymphocyte Activation; Phytohemagglutinins; Thromboxane B2; Thromboxanes; Thymidine; Time Factors | 1979 |
Inhibition of platelet cyclooxygenase by aspirin-like drugs: methods for in vitro and ex vivo assessment.
Topics: Anti-Inflammatory Agents; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Humans; Indomethacin; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 1979 |
Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders.
Topics: Adult; Aged; Arachidonic Acids; Aspirin; Blood Platelets; Female; Humans; Lipoxygenase; Male; Middle Aged; Myeloproliferative Disorders; Platelet Aggregation; Prostaglandins E; Prostaglandins F; Thromboxane B2; Time Factors | 1979 |
Anti-inflammatory drugs in experimental atherosclerosis. Part 4. Inhibition of atherosclerosis in vivo and thromboxane synthesis and platelet aggregation in vitro.
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Arteriosclerosis; Aspirin; Drug Evaluation; Flufenamic Acid; In Vitro Techniques; Male; Mefenamic Acid; Phenylbutazone; Platelet Aggregation; Rabbits; Thromboxane B2 | 1979 |
Inhibition of thromboxane B2 and 6-ketoprostaglandin F1 alpha formation by anti-inflammatory drugs in carrageenin-induced granuloma.
Topics: Animals; Arachidonic Acids; Aspirin; Carrageenan; Depression, Chemical; Granuloma; Hydrocortisone; In Vitro Techniques; Indomethacin; Male; Prostaglandins F; Rats; Thromboxane B2; Thromboxanes | 1978 |
Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics.
Topics: Adult; Allergens; Aspirin; Asthma; Bronchial Provocation Tests; Female; Histamine; Humans; Leukotriene E4; Male; Middle Aged; SRS-A; Thromboxane B2 | 1992 |
Increased thromboxane biosynthesis in patients with polycythemia vera: evidence for aspirin-suppressible platelet activation in vivo.
Topics: Adult; Aged; Aspirin; Blood Platelets; Female; Humans; Kinetics; Leukotriene E4; Male; Middle Aged; Platelet Activation; Polycythemia Vera; SRS-A; Thromboxane A2; Thromboxane B2 | 1992 |
Arachidonic acid metabolism in monocytes of aspirin-sensitive asthmatic patients before and after oral aspirin challenge.
Topics: Administration, Oral; Adult; Arachidonic Acid; Aspirin; Asthma; Bronchial Spasm; Calcimycin; Eicosanoids; Female; Humans; Leukotriene B4; Male; Middle Aged; Monocytes; Thromboxane B2 | 1992 |
Dissociation of inhibitory effects of low-dose ASA on thromboxane production and platelet aggregation in ischemic stroke patients.
Topics: Aged; Aspirin; Cerebrovascular Disorders; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Thromboxane B2 | 1992 |
Residual platelet function under acetylsalicylic acid and the risk of restenosis after coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Coronary Disease; Cyclic AMP; Female; Humans; Male; Platelet Aggregation; Recurrence; Thromboxane B2 | 1992 |
Effects of intravenous infusions of diaspirin cross-linked hemoglobin (DCLHb) on sheep.
Topics: Animals; Aspirin; Blood Substitutes; Complement C3a; Cross-Linking Reagents; Drug Tolerance; Female; Hemoglobins; Inflammation; Infusions, Intravenous; Safety; Serum Albumin; Sheep; Thromboxane B2 | 1992 |
Urinary 11-dehydro-thromboxane B2: a quantitative index of platelet activation in cerebral infarction.
Topics: Adult; Aged; Arteriosclerosis; Aspirin; Atrial Fibrillation; Carotid Artery Diseases; Cerebral Infarction; Female; Humans; Male; Middle Aged; Platelet Activation; Thromboxane A2; Thromboxane B2 | 1992 |
Intravenous acetylsalicylic acid--dose-related effects on platelet function and fibrinolysis in healthy males.
Topics: Adult; Aspirin; Bleeding Time; Blood Platelets; Dose-Response Relationship, Drug; Fibrinolysis; Humans; Injections, Intravenous; Male; Thromboxane B2; Time Factors | 1992 |
Effects of low-to-high doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclin.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aspirin; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Epoprostenol; Female; Humans; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1992 |
Study of thromboxane and prostacyclin metabolism in an in vitro model of first-trimester human trophoblast.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Aspirin; Chorionic Villi; Epoprostenol; Female; Humans; Karyotyping; Pregnancy; Pregnancy Trimester, First; Thromboxane B2; Thromboxanes; Trophoblasts | 1992 |
Effects of cyclooxygenase inhibitors on ex vivo cysteinyl-leukotriene production by whole human blood allowed to clot spontaneously. Comparison to stimulated blood.
Topics: Adult; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Aspirin; Blood Coagulation; Calcimycin; Cyclooxygenase Inhibitors; Depression, Chemical; Dose-Response Relationship, Drug; Humans; Ibuprofen; Leukotrienes; Male; N-Formylmethionine Leucyl-Phenylalanine; Thromboxane B2 | 1992 |
Evidence of increased platelet activation after thrombolysis in patients with acute myocardial infarction.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Streptokinase; Thrombolytic Therapy; Thromboxane B2; Thromboxanes | 1992 |
Prevalence and mechanism of streptokinase-induced platelet stimulation. Effect of acetylsalicylic acid.
Topics: Adult; Aspirin; Female; Humans; Immunoglobulin E; Immunoglobulin G; In Vitro Techniques; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Radioallergosorbent Test; Streptokinase; Thrombolytic Therapy; Thromboxane B2 | 1992 |
Effect of anethole dithiolthione on human platelet aggregation.
Topics: Adenosine Diphosphate; Adult; Anethole Trithione; Arachidonic Acid; Aspirin; Butylated Hydroxytoluene; Humans; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Radioimmunoassay; Thrombin; Thromboxane B2 | 1992 |
[A trial of low-dose aspirin therapy in high-risk pregnancy].
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Calcium; Female; Fetal Death; Fetal Growth Retardation; Humans; Lupus Coagulation Inhibitor; Placenta; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Thromboxane B2; Treatment Outcome | 1992 |
Relevance of vasoactive mediators for the blood pressure effects of intravenous arachidonic acid injection in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Aspirin; Blood Pressure; Cyproheptadine; Diterpenes; Ginkgolides; Imidazoles; Injections, Intravenous; Lactones; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sulfonamides; Thromboxane B2 | 1992 |
Contribution of platelet thromboxane production to enhanced urinary excretion and glomerular production of thromboxane and to the pathogenesis of albuminuria in the streptozotocin-diabetic rat.
Topics: Albuminuria; Animals; Aspirin; Blood Platelets; Diabetes Mellitus, Experimental; Dinoprostone; Female; Glomerular Filtration Rate; Kidney Glomerulus; Rats; Rats, Inbred Strains; Thrombocytopenia; Thromboxane B2 | 1992 |
Differential effect of aspirin on platelet aggregation in IDDM.
Topics: Adult; Aspirin; Blood Pressure; Cholesterol; Collagen; Diabetes Mellitus, Type 1; Fatty Acids, Omega-3; Humans; Linoleic Acid; Linoleic Acids; Male; Membrane Fluidity; Phospholipids; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Thromboxane B2 | 1992 |
Comparison of hypoxia-induced contraction in human, monkey, and dog coronary arteries.
Topics: Animals; Aspirin; Coronary Vessels; Dinoprost; Dogs; Endothelium, Vascular; Female; Humans; Hypoxia; In Vitro Techniques; Indomethacin; Isometric Contraction; Macaca; Male; Methacrylates; Muscle Relaxation; Muscle, Smooth, Vascular; Papaverine; Prostaglandins; Species Specificity; Superoxide Dismutase; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 1992 |
Protective effect of the new antiplatelet agent 2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine on myocardial damage due to coronary occlusion and reperfusion in rabbit.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspartate Aminotransferases; Aspirin; Bridged Bicyclo Compounds; Chemotaxis, Leukocyte; Creatine Kinase; Guinea Pigs; L-Lactate Dehydrogenase; Male; Myocardial Infarction; Myocardial Reperfusion Injury; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nicotinic Acids; Platelet Aggregation Inhibitors; Rabbits; Thromboxane B2 | 1992 |
Effect of skin temperature on platelet function in patients undergoing extracorporeal bypass.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Bleeding Time; Blood Platelets; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Humans; Male; Middle Aged; Platelet Function Tests; Skin Temperature; Thromboxane B2 | 1992 |
Triflusal vs aspirin on the inhibition of human platelet and vascular cyclooxygenase.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Salicylates; Thromboxane B2 | 1992 |
Increased lipopolysaccharide-induced tissue factor activity and tumour necrosis factor production in monocytes after intake of aspirin: possible role of prostaglandin E2.
Topics: Adult; Aspirin; Dinoprostone; Female; Humans; Lipopolysaccharides; Male; Middle Aged; Monocytes; Thromboplastin; Thromboxane B2; Tumor Necrosis Factor-alpha | 1992 |
The relationship between thromboxane and cytosolic calcium modifiers in rat platelets.
Topics: Animals; Aspirin; Blood Platelets; Calcium; Calcium Chloride; Collagen; Cytosol; Dietary Fats; Fatty Acids; Linoleic Acid; Linoleic Acids; Male; Nifedipine; Ouabain; Rats; Rats, Zucker; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Thrombin; Thromboxane B2 | 1991 |
Intraoperative management of patients with heparin-induced thrombocytopenia.
Topics: Adult; Aged; Aspirin; beta-Thromboglobulin; Bleeding Time; Epoprostenol; Fibrinopeptide A; Heparin; Humans; Iloprost; Intraoperative Period; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Factor 4; Thrombocytopenia; Thromboxane B2 | 1990 |
The effects of an infusion of prostacyclin on their endotoxin shock in rabbits.
Topics: Animals; Aspirin; Blood Coagulation; Blood Platelets; Blood Pressure; Carbon Dioxide; Epoprostenol; Fibrin; Fibrinogen; Lactates; Lactic Acid; Leukocyte Count; Oxygen; Partial Thromboplastin Time; Platelet Aggregation; Platelet Count; Prothrombin Time; Rabbits; Shock, Septic; Survival Analysis; Thromboxane B2 | 1990 |
Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Aspirin; beta-Thromboglobulin; Blood Platelets; Collagen; Erythrocytes; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Membrane Glycoproteins; Serotonin; Thromboxane A2; Thromboxane B2; Thromboxanes | 1991 |
Urinary excretion of thromboxane and prostacyclin metabolites during chronic low-dose aspirin: evidence for an extrarenal origin of urinary thromboxane B2 and 6-keto-prostaglandin F1 alpha in healthy subjects.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Epoprostenol; Humans; Male; Thromboxane B2; Thromboxanes; Urine | 1992 |
Thromboxane plasma level in kappa-carrageenin-induced acronecrosis of the tail in rats.
Topics: Animals; Aspirin; Carrageenan; Chlorpromazine; Dexamethasone; Heparin; Imidazoles; Naphthalenes; Necrosis; Pentanoic Acids; Pyridines; Radioimmunoassay; Rats; Rats, Inbred Strains; Thromboxane A2; Thromboxane B2 | 1991 |
Presystemic acetylation of platelets by aspirin: reduction in rate of drug delivery to improve biochemical selectivity for thromboxane A2.
Topics: Acetylation; Aspirin; Blood Platelets; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Delivery Systems; Duodenum; Humans; Intestinal Absorption; Liver; Male; Thromboxane A2; Thromboxane B2 | 1991 |
Maximal blockade of TxA2 without compromised PGI2 formation; a superior profile of the TxA2 receptor blocking drug GR32191 over aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Biphenyl Compounds; Dose-Response Relationship, Drug; Epoprostenol; Heptanoic Acids; Humans; Male; Platelet Aggregation; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane B2 | 1991 |
Thromboxane-dependent platelet activation as a transducer of enhanced risk of coronary and cerebral thrombosis.
Topics: Aspirin; Coronary Thrombosis; Cross-Sectional Studies; Humans; Intracranial Embolism and Thrombosis; Platelet Activation; Risk Factors; Thromboxane A2; Thromboxane B2 | 1991 |
Rebound elevation in urinary thromboxane B2 and 6-keto-PGF1 alpha excretion after aspirin withdrawal.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Disease Susceptibility; Female; Humans; Male; Random Allocation; Thrombosis; Thromboxane B2; Time Factors | 1991 |
Lung vascular injury after administration of viable hemolysin-forming Escherichia coli in isolated rabbit lungs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Pressure; Capillary Permeability; Epoprostenol; Escherichia coli; Female; Hemolysin Proteins; Hypertension, Pulmonary; In Vitro Techniques; L-Lactate Dehydrogenase; Lung; Male; Neutrophils; Perfusion; Potassium; Pulmonary Artery; Rabbits; Receptors, Prostaglandin; Receptors, Thromboxane; Respiratory Insufficiency; Sulfonamides; Thromboxane B2; Thromboxanes | 1991 |
Benefit/risk profile of combined antiplatelet therapy with ticlopidine and aspirin.
Topics: Aged; Aspirin; Bleeding Time; Drug Synergism; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Thromboxane B2; Ticlopidine | 1991 |
Platelet hypersensitivity in cholesterol-fed rabbits: enhancement of thromboxane A2-dependent and thrombin-induced, thromboxane A2-independent platelet responses.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Cholesterol; Collagen; Hypercholesterolemia; Male; Platelet Aggregation; Platelet Count; Prostaglandin Endoperoxides, Synthetic; Rabbits; Serotonin; Thrombin; Thromboxane A2; Thromboxane B2 | 1991 |
In vitro antiplatelet profiles of the new thromboxane synthetase inhibitor sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylate.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Animals; Aspirin; Dogs; Humans; Imidazoles; In Vitro Techniques; Male; Methacrylates; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thiophenes; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1991 |
Antithrombotic actions of aspirin in the horse.
Topics: Adenosine Diphosphate; Animals; Aspirin; Bleeding Time; Blood Platelets; Collagen; Horses; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 1991 |
In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Drug Interactions; Female; Humans; Male; Malondialdehyde; Phthalic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Sulfonamides; Thromboxane B2 | 1991 |
Effect of aspirin on local prostaglandin production and serotonin accumulation in a canine model with coronary cyclic flow variations or thrombosis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Coronary Circulation; Coronary Disease; Coronary Thrombosis; Dogs; Electricity; Female; Male; Platelet Aggregation; Serotonin; Thromboxane B2 | 1991 |
Thromboxane A2 synthesis in pregnancy-induced hypertension.
Topics: Adolescent; Adult; Aspirin; Evaluation Studies as Topic; Female; Humans; Hypertension; Platelet Activation; Platelet Count; Pregnancy; Pregnancy Complications, Cardiovascular; Severity of Illness Index; Thromboxane A2; Thromboxane B2 | 1990 |
Increased platelet turnover in a patient with previous recurrent pre-eclampsia and failure of aspirin therapy. Case report.
Topics: Adult; Aspirin; Blood Platelets; Female; Humans; Platelet Activating Factor; Platelet Aggregation; Pre-Eclampsia; Pregnancy; Thromboxane B2 | 1991 |
In vivo platelet activation in beta-thalassemia major reflected by increased platelet-thromboxane urinary metabolites.
Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Aspirin; Female; Humans; Male; Platelet Activation; Thalassemia; Thromboxane B2 | 1991 |
Lipopolysaccharide from Escherichia coli reduces antigen-induced bronchoconstriction in actively sensitized guinea pigs.
Topics: Animals; Antigens; Aspirin; Bronchoconstriction; Cell Degranulation; Endotoxins; Escherichia coli; Guinea Pigs; Hemodynamics; Histamine; Hypersensitivity; Leukopenia; Lipopolysaccharides; Mast Cells; Microscopy, Electron; N-Formylmethionine Leucyl-Phenylalanine; Ovalbumin; Platelet Activating Factor; Pyrilamine; Thromboxane B2 | 1991 |
Platelet aggregation in flowing blood at a site of injury to an endothelial cell monolayer: quantitation and real-time imaging with the TAB monoclonal antibody.
Topics: Animals; Antibodies, Monoclonal; Aspirin; Cattle; Endothelium, Vascular; Epoprostenol; Humans; In Vitro Techniques; Lysine; Platelet Adhesiveness; Platelet Aggregation; Platelet Membrane Glycoproteins; Rheology; Stress, Mechanical; Thromboxane B2; Video Recording | 1990 |
Glutathione disulfide production during arachidonic acid oxygenation in human platelets.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Glutathione; Glutathione Disulfide; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Thrombin; Thromboxane B2 | 1990 |
Enhancement of sickle erythrocyte adherence to endothelium by autologous platelets.
Topics: Anemia, Sickle Cell; Aspirin; Blood Platelets; Cell Adhesion; Endothelium, Vascular; Epoprostenol; Erythrocyte Aggregation; Erythrocytes; Erythrocytes, Abnormal; Hemoglobin, Sickle; Humans; Thromboxane B2 | 1990 |
Platelet thromboxane A2/prostaglandin H2 receptors in human volunteers on low doses of aspirin.
Topics: Adult; Aspirin; Blood Platelets; Female; Humans; Male; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thrombin; Thromboxane A2; Thromboxane B2 | 1990 |
Effect of a thromboxane A2 synthetase inhibitor (OKY-046.HCl) on airway hyperresponsiveness in guinea pigs.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Airway Resistance; Animals; Antigens; Aspirin; Bronchoalveolar Lavage Fluid; Guinea Pigs; Leukotriene E4; Methacrylates; N-Formylmethionine Leucyl-Phenylalanine; Phthalazines; Physostigmine; Platelet Activating Factor; Propranolol; Respiratory System; SRS-A; Thromboxane B2; Thromboxane-A Synthase | 1990 |
Time of low-dose acetylsalicylic acid administration influences in vivo platelet function and thrombus formation following arteriotomy and intimectomy; an experimental study in small arteries of rabbits.
Topics: Animals; Arteries; Aspirin; Blood Coagulation; Blood Platelets; Ear, External; Female; Male; Microscopy, Electron, Scanning; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thrombosis; Thromboxane B2; Time Factors; Vascular Patency | 1990 |
Low-dose aspirin. II. Relationship of angiotensin II pressor responses, circulating eicosanoids, and pregnancy outcome.
Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Analysis of Variance; Angiotensin II; Aspirin; Blood Pressure; Chi-Square Distribution; Dinoprostone; Eicosanoids; Female; Humans; Hypertension; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Pregnancy Trimester, Third; Thromboxane B2 | 1990 |
The antiplatelet effect of daily low dose enteric-coated aspirin in man: a time course of onset and recovery.
Topics: Adolescent; Adult; Aspirin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Platelet Aggregation Inhibitors; Tablets, Enteric-Coated; Thromboxane B2 | 1990 |
Picotamide protects mice from death in a pulmonary embolism model by a mechanism independent from thromboxane suppression.
Topics: Animals; Aspirin; Disease Models, Animal; Epoprostenol; Male; Mice; Phthalic Acids; Platelet Aggregation Inhibitors; Platelet Count; Pulmonary Embolism; Thromboxane B2 | 1990 |
[Thrombocyte aggregation and serum thromboxane in patients with acute myocardial infarction].
Topics: Aged; Aspirin; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Thromboxane B2 | 1990 |
Induction of platelet Ca2+ influx and mobilization by a monoclonal antibody to CD9 antigen.
Topics: Adenosine Triphosphate; Antibodies, Monoclonal; Antigen-Antibody Reactions; Antigens, CD; Antigens, Differentiation; Aspirin; Blood Platelets; Calcium; Creatine Kinase; Humans; In Vitro Techniques; Membrane Glycoproteins; Phosphocreatine; Platelet Activation; Platelet Membrane Glycoproteins; Tetraspanin 29; Thrombasthenia; Thromboxane B2; Time Factors | 1990 |
Low dose acetylsalicylic acid and thromboxane release at the site of plug formation in vivo in elderly patients with cardiovascular disease.
Topics: Aged; Aged, 80 and over; Aspirin; Bleeding Time; Cardiovascular Diseases; Cerebrovascular Disorders; Hemostasis; Humans; Thromboxane B2 | 1990 |
Protective effect of Y-20811, a long-lasting thromboxane synthetase inhibitor, on endotoxin shock in rabbits.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Pressure; Imidazoles; Male; Rabbits; Shock, Septic; Survival Rate; Thromboxane B2; Thromboxane-A Synthase | 1990 |
Ethanol increases PGE and thromboxane production in mouse pregnant uterine tissue.
Topics: Analysis of Variance; Animals; Aspirin; Ethanol; Female; Mice; Mice, Inbred C57BL; Pregnancy; Pregnancy, Animal; Prostaglandins E; Thromboxane B2; Uterus | 1990 |
Thromboxane biosynthesis and platelet function in type II diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Thromboxanes | 1990 |
Contact phase of coagulation in diabetes mellitus after aspirin administration.
Topics: Aspirin; Blood Coagulation; Blood Platelets; Diabetes Mellitus, Type 1; Factor XI; Factor XII; Female; Humans; Male; Middle Aged; Prekallikrein; Thromboxane B2 | 1985 |
PF 4 versus beta TG as evidence for platelet activation in myeloproliferative disorders.
Topics: Adult; Age Factors; Aged; Aspirin; Beta-Globulins; beta-Thromboglobulin; Dipyridamole; Female; Humans; Male; Middle Aged; Myeloproliferative Disorders; Platelet Count; Platelet Factor 4; Thromboxane B2 | 1985 |
Effects of current therapy of Kawasaki disease on eicosanoid metabolism.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Child; Child, Preschool; Drug Therapy, Combination; gamma-Globulins; Humans; Infant; Infusions, Intravenous; Mucocutaneous Lymph Node Syndrome; Prostaglandins E; Thromboxane B2; Time Factors | 1988 |
Exposure of platelet fibrinogen receptors by a monoclonal antibody to CD9 antigen.
Topics: Animals; Antibodies, Monoclonal; Antigen-Antibody Reactions; Antigens, CD; Antigens, Differentiation; Aspirin; Binding Sites, Antibody; Blood Platelets; Epitopes; Fibrinogen; Humans; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Phosphocreatine; Platelet Aggregation; Platelet Membrane Glycoproteins; Tetraspanin 29; Thromboxane B2 | 1988 |
High concentrations of exogenous arachidonate inhibit calcium mobilization in platelets by stimulation of adenylate cyclase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenylyl Cyclases; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcium; Cyclic AMP; Deoxyadenosines; Dideoxyadenosine; Enzyme Induction; Epoprostenol; Humans; Iloprost; In Vitro Techniques; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Pyrazoles; Thromboxane B2 | 1988 |
Differential inhibition by aspirin of platelet thromboxane and renal prostaglandins in the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dinoprostone; Injections, Intravenous; Kidney; Male; Rats; Rats, Inbred Strains; Thromboxane B2 | 1989 |
Evidence for a bidirectional prostaglandin endoperoxide shunt between platelets and the bovine coronary artery.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cattle; Coronary Vessels; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Epoprostenol; Humans; Imidazoles; Intramolecular Oxidoreductases; Isomerases; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Pyridines; Thromboxane B2; Thromboxane-A Synthase | 1989 |
Selective inhibition of platelet thromboxane generation with low-dose aspirin does not protect rats with reduced renal mass from the development of progressive disease.
Topics: Animals; Aspirin; Blood Platelets; Kidney; Kidney Diseases; Kidney Glomerulus; Male; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Proteinuria; Rats; Rats, Inbred Strains; Thromboxane B2 | 1989 |
Contraction of the rat isolated aorta caused by Clostridium perfringens alpha toxin (phospholipase C): evidence for the involvement of arachidonic acid metabolism.
Topics: Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Bacterial Toxins; Calcium-Binding Proteins; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Male; Methacrylates; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Thromboxane B2; Thromboxane-A Synthase; Type C Phospholipases | 1989 |
Inhibition of human platelet function in vitro and ex vivo by acetaminophen.
Topics: Acetaminophen; Arachidonic Acids; Aspirin; Blood Platelets; Calcimycin; Collagen; Epinephrine; Humans; In Vitro Techniques; Indomethacin; Platelet Aggregation Inhibitors; Serotonin; Thromboxane B2 | 1989 |
[Effects of low-dose acetylsalicylic acid on thrombocytes in health subjects and in patients with coronary heart disease].
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Coronary Disease; Dose-Response Relationship, Drug; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Thromboxane B2; Time Factors | 1989 |
Aspirin-like effects of selected food additives and industrial sensitizing agents.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Female; Food Additives; Humans; Hypersensitivity; Male; Middle Aged; Pharmaceutic Aids; Phthalic Anhydrides; Platelet Aggregation; Platelet Aggregation Inhibitors; Sulfites; Thromboxane B2 | 1989 |
Thromboxane A2 and prostacyclin generation in the microvasculature of patients with atherosclerosis--effect of low-dose aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Arteriosclerosis; Aspirin; Bleeding Time; Blood Platelets; Drug Administration Schedule; Endothelium, Vascular; Epoprostenol; Female; Humans; Male; Microcirculation; Middle Aged; Thromboxane A2; Thromboxane B2 | 1989 |
Thromboxane is produced in response to intracoronary infusions of complement C5a in pigs. Cyclooxygenase blockade does not reduce the myocardial ischemia and leukocyte accumulation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Complement C5a; Coronary Disease; Coronary Vessels; Cyclooxygenase Inhibitors; Female; Indomethacin; Injections, Intra-Arterial; Leukocyte Count; Leukocytes; Male; Myocardium; Prostaglandin Endoperoxides, Synthetic; Swine; Thromboxane B2; Thromboxanes | 1989 |
Cyclooxygenase inhibition in lungs or in neutrophils attenuates neutrophil-dependent edema in rat lungs perfused with phorbol myristate acetate.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Cyclooxygenase Inhibitors; Lung; Male; Neutrophils; Oxygen; Pulmonary Edema; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1989 |
Oxidant-mediated activation of phospholipase A2 in pulmonary endothelium.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Calcium Channel Blockers; Cattle; Cells, Cultured; Cycloheximide; Dactinomycin; Dexamethasone; Dinoprostone; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Kinetics; Peroxides; Phospholipases; Phospholipases A; Phospholipases A2; Prostaglandin D2; Pulmonary Artery; tert-Butylhydroperoxide; Thromboxane B2; Vitamin E | 1989 |
Human platelets modulate edema formation in isolated rabbit lungs.
Topics: Animals; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Dehydroepiandrosterone; Fatty Acids, Unsaturated; Female; Glucosephosphate Dehydrogenase; Humans; Hydrazines; Male; Papaverine; Perfusion; Pulmonary Edema; Pulmonary Wedge Pressure; Purines; Rabbits; Thromboxane B2; Xanthine Oxidase | 1989 |
Prostaglandin E2 inhibits and indomethacin and aspirin enhance, A23187-stimulated leukotriene B4 synthesis by rat peritoneal macrophages.
Topics: Animals; Aspirin; Calcimycin; In Vitro Techniques; Indomethacin; Leukotriene B4; Macrophages; Male; Prostaglandins E; Rats; Rats, Inbred Strains; Thromboxane B2 | 1989 |
Platelet aggregation in the Asian elephant is not dependent on thromboxane B2 production.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Elephants; Female; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Verapamil | 1989 |
Effect of low dose acetylsalicylic acid upon plasma thromboxane B2 levels and platelet aggregation in ischemic stroke patients.
Topics: Adenosine Diphosphate; Aged; Aspirin; Brain Ischemia; Cerebrovascular Disorders; Female; Humans; Male; Middle Aged; Platelet Aggregation; Random Allocation; Thromboxane B2 | 1989 |
[The relationship between high-density lipoproteins, thromboxane B2 and arteriosclerosis in a case of primary hypoalphalipoproteinemia].
Topics: Adult; Arteriosclerosis; Aspirin; Chronic Disease; Histiocytes; Humans; Hypolipoproteinemias; Lipoproteins, HDL; Lymph Nodes; Male; Skin; Thromboxane B2 | 1989 |
Healing of necrobiotic ulcers with antiplatelet therapy. Correlation with plasma thromboxane levels.
Topics: Adult; Aged; Aspirin; Blood Platelets; Dipyridamole; Drug Therapy, Combination; Humans; Leg Ulcer; Male; Middle Aged; Necrobiosis Lipoidica; Radioimmunoassay; Thromboxane B2 | 1989 |
Renal metabolism and urinary excretion of thromboxane B2 in the rat.
Topics: Animals; Aspirin; Kidney; Perfusion; Rats; Rats, Inbred Strains; Thromboxane B2 | 1989 |
In vivo measurement of thromboxane B2 and 6-keto-prostaglandin F1 alpha in humans in response to a standardized vascular injury and the influence of aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Bleeding Time; Diabetes Mellitus; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Sex Characteristics; Smoking; Thromboxane B2; Time Factors | 1989 |
PAF-induced platelet aggregation and TXB2 formation.
Topics: Aspirin; Humans; Platelet Activating Factor; Platelet Aggregation; Thromboxane B2 | 1989 |
Effect of changes in prostaglandin synthesis by platelets and vessel wall on the formation of arterial thrombosis in rabbits.
Topics: Animals; Aspirin; Blood Platelets; Femoral Artery; Platelet Aggregation; Prostaglandins; Rabbits; Thrombosis; Thromboxane B2 | 1985 |
Investigation of alternative mechanisms of collagen-induced platelet activation by using monoclonal antibodies to glycoprotein IIb-IIIa and fibrinogen.
Topics: Antibodies, Monoclonal; Aspirin; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Fibrinogen; Glycoproteins; Humans; Iodine Radioisotopes; Membrane Proteins; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Binding; Structure-Activity Relationship; Thromboxane B2 | 1986 |
Antiplatelet therapy and vascular grafts. Studies in a baboon ex vivo shunt.
Topics: Animals; Aspirin; Bleeding Time; Blood Coagulation; Blood Platelets; Blood Vessel Prosthesis; Graft Occlusion, Vascular; Heparin; Male; Papio; Polyethylene Terephthalates; Polytetrafluoroethylene; Thromboxane B2 | 1986 |
Investigation of the interaction of blood platelets with the coagulation system at the site of plug formation in vivo in man--effect of low-dose aspirin.
Topics: Adult; Aspirin; beta-Thromboglobulin; Bleeding Time; Blood Coagulation; Blood Platelets; Fibrinopeptide A; Hemostasis; Humans; Male; Platelet Aggregation; Thrombin; Thromboxane B2 | 1987 |
Effect of a selective thromboxane synthase inhibitor on arterial graft patency and platelet deposition in dogs.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Arteries; Aspirin; Benzofurans; Blood Platelets; Blood Vessel Prosthesis; Carotid Arteries; Dipyridamole; Dogs; Female; Indium; Polyethylene Terephthalates; Polytetrafluoroethylene; Radioisotopes; Random Allocation; Thromboxane B2; Thromboxane-A Synthase | 1987 |
In vivo formation of prostacyclin and thromboxane A2 at the site of platelet-vascular interaction in humans.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Bleeding Time; Blood Platelets; Blood Vessels; Epoprostenol; Female; Humans; Male; Thromboxane A2; Thromboxane B2 | 1987 |
Characteristics of thromboxane production by the isolated-perfused rat heart.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Heart; Ibuprofen; In Vitro Techniques; Methacrylates; Myocardium; Perfusion; Rats; Thromboxane B2 | 1987 |
Radioimmunoassay measurement of 2,3-dinor metabolites of prostacyclin and thromboxane in human urine.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Female; Humans; Kidney; Male; Radioimmunoassay; Sulindac; Thromboxane B2 | 1987 |
Analysis of multiple thromboxane metabolites in plasma and urine.
Topics: Aspirin; Humans; Thromboxane B2; Thromboxanes; Vascular Diseases | 1987 |
Effects of triflusal and acetylsalicylic acid on platelet aggregation in whole blood of diabetic patients.
Topics: Adult; Aspirin; beta-Thromboglobulin; Diabetes Mellitus, Type 1; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins F; Salicylates; Thromboxane B2 | 1988 |
The effect of the thromboxane receptor antagonist BM 13.177 on experimentally induced coronary artery thrombosis in the pig.
Topics: Animals; Anti-Arrhythmia Agents; Aspirin; Coronary Disease; Coronary Thrombosis; Electric Stimulation; Hemodynamics; In Vitro Techniques; Platelet Aggregation; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Swine; Thromboxane B2 | 1988 |
Comparison of the effects of some compounds on human neutrophil degranulation and leukotriene B4 and thromboxane B2 synthesis.
Topics: Arachidonic Acids; Aspirin; Calcimycin; Humans; In Vitro Techniques; Indomethacin; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenylbutazone; Thromboxane B2; Thromboxanes | 1985 |
Synergistic actions of PAF-acether and sodium arachidonate in human platelet aggregation. 1. Studies in normal human platelet rich plasma.
Topics: Adult; Arachidonic Acids; Aspirin; Dose-Response Relationship, Drug; Drug Synergism; Humans; Lipoxygenase Inhibitors; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thromboxane B2; Time Factors | 1986 |
Inhibition of platelet thromboxane generation by suloctidil in man.
Topics: Adult; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Dinoprostone; Drug Interactions; Epoprostenol; Female; Humans; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Propanolamines; Prostaglandins E; Rats; Suloctidil; Thromboxane A2; Thromboxane B2 | 1986 |
Low-dose aspirin inhibits thromboxane, but not prostacyclin, production by human placental arteries.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Arteries; Aspirin; Epoprostenol; Female; Humans; Placenta; Pregnancy; Thromboxane B2 | 1988 |
Effects of Gramoxone-induced reactive oxygen radicals on eicosanoid synthesis of mouse lung.
Topics: Animals; Aspirin; Epoprostenol; Female; Free Radicals; Lethal Dose 50; Lipid Peroxidation; Lung; Male; Mice; Oxygen; Paraquat; Superoxide Dismutase; Thromboxane A2; Thromboxane B2 | 1988 |
Altered renal and platelet arachidonic acid metabolism in cirrhosis.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Kidney Injury; Adult; Aged; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Creatinine; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Epoprostenol; Female; Humans; Kidney; Liver Cirrhosis; Male; Middle Aged; Natriuresis; Prostaglandins E; Prostaglandins F; Renin-Angiotensin System; Sulindac; Thromboxane A2; Thromboxane B2 | 1986 |
Aspirin does not inhibit human megakaryocyte thromboxane synthesis in vivo.
Topics: Aspirin; Blood Platelets; Bone Marrow Cells; Cyclooxygenase Inhibitors; Humans; Megakaryocytes; Platelet Count; Thromboxane B2 | 1986 |
The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation in man and the rat.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Creatine Kinase; Dose-Response Relationship, Drug; Humans; Imidazoles; In Vitro Techniques; Male; Phosphocreatine; Platelet Aggregation; Prostaglandin Endoperoxides; Rats; Rats, Inbred Strains; Species Specificity; Thromboxane A2; Thromboxane B2 | 1986 |
Role of lipoxygenase metabolism in platelet function: effect of aspirin and salicylate.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Aspirin; Blood Platelets; Collagen; Humans; Hydroxyeicosatetraenoic Acids; Lipoxygenase; Platelet Adhesiveness; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Salicylates; Salicylic Acid; Thromboxane B2 | 1986 |
Activation of protein kinase C inhibits sodium fluoride-induced elevation of human platelet cytosolic free calcium and thromboxane B2 generation.
Topics: Aspirin; Blood Platelets; Calcium; Chlorides; Cytosol; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Humans; Manganese; Manganese Compounds; Protein Kinase C; Serotonin; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1986 |
Regulation of thromboxane A2 biosynthesis in platelet-free human monocytes and the possible role of polypeptide growth factor(s) in the induction of cyclooxygenase system.
Topics: ABO Blood-Group System; Animals; Aspirin; Blood; Cattle; Dactinomycin; Dinoprostone; Enzyme Induction; Humans; Hydrogen-Ion Concentration; Indomethacin; Kinetics; Monocytes; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Thromboxane A2; Thromboxane B2 | 1986 |
Long-lived enzymatic metabolites of thromboxane B2 in the human circulation.
Topics: Adult; Animals; Aspirin; Chromatography, Thin Layer; Deuterium; Gas Chromatography-Mass Spectrometry; Guinea Pigs; Half-Life; Humans; In Vitro Techniques; Male; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 1986 |
Biochemical selectivity of oral versus intravenous aspirin in rats. Inhibition by oral aspirin of cyclooxygenase activity in platelets and presystemic but not systemic vessels.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Aorta, Abdominal; Aspirin; Blood Platelets; Blood Vessels; Injections, Intravenous; Male; Portal Vein; Prostaglandin-Endoperoxide Synthases; Rats; Thromboxane B2; Vena Cava, Inferior | 1986 |
Time-dependent inhibition of platelet cyclooxygenase by indomethacin is slowly reversible.
Topics: Adult; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Kinetics; Male; Microsomes; Thromboxane B2 | 1986 |
Synergistic actions of paf-acether and sodium arachidonate in human platelet aggregation. 2. Unexpected results after aspirin intake.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenosine; Administration, Oral; Adult; Apyrase; Arachidonic Acids; Aspirin; Catechols; Drug Synergism; Epoprostenol; Humans; Indomethacin; Masoprocol; Platelet Activating Factor; Platelet Aggregation; Pyrazoles; Thromboxane B2; Time Factors; Umbelliferones | 1986 |
Dazoxiben, UK 38,485 and aspirin: duration of effect for preventing thrombotic sudden death in rabbits.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Imidazoles; Male; Rabbits; Thrombocytopenia; Thrombosis; Thromboxane B2; Time Factors | 1986 |
Beneficial effect of aspirin in maintaining the patency of small-caliber prosthetic grafts after thrombolysis with urokinase or tissue-type plasminogen activator.
Topics: Animals; Aspirin; Blood Vessel Prosthesis; Dogs; Graft Occlusion, Vascular; Platelet Aggregation; Polytetrafluoroethylene; Thrombosis; Thromboxane B2; Time Factors; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 1986 |
Trial of repeated low-dose aspirin in diabetic angiopathy.
Topics: Adenosine Triphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Diabetes Mellitus; Diabetic Angiopathies; Drug Administration Schedule; Female; Humans; Male; Malondialdehyde; Middle Aged; Platelet Aggregation; Thromboxane B2 | 1986 |
In vitro effects of aspirin and non steroidal anti-inflammatory drugs on the formation of 12-hydroxyeicosatetraenoic acid by platelets.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Anti-Inflammatory Agents; Aspirin; Blood Platelets; Collagen; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Lipoxygenase; Platelet Aggregation; Pyrazoles; Sodium Salicylate; Thromboxane B2 | 1986 |
Pharmacological modulation of the effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine in guinea-pigs: involvement of the arachidonic acid cascade.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Cell Count; Blood Platelets; Bronchi; Female; Guinea Pigs; Indomethacin; Lung; Male; Microscopy, Electron; N-Formylmethionine Leucyl-Phenylalanine; Pyrazoles; Thromboxane B2 | 1986 |
Low-dose enteric-coated aspirin: a practical approach to continuous-release low-dose aspirin and presystemic acetylation of human platelet cyclooxygenase.
Topics: Acetylation; Aspirin; Bleeding Time; Blood Platelets; Drug Administration Schedule; Humans; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Tablets, Enteric-Coated; Thromboxane A2; Thromboxane B2 | 1986 |
Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man.
Topics: Adenosine Diphosphate; Adolescent; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Thromboxane B2; Thromboxanes | 1986 |
Comparison of the effects of oral and intravenous aspirin administration on platelet and peripheral vascular cyclo-oxygenase activity: studies in rats and in man.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Aspirin; Biological Availability; Blood Platelets; Blood Vessels; Female; Fibrinolysis; Humans; Injections, Intravenous; Kinetics; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Rats; Thromboxane B2 | 1986 |
Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Inflammation; Kinetics; Male; Prostaglandins E; Rats; Rats, Inbred Strains; Salicylates; Thromboxane B2 | 1987 |
Prolongation of rat cardiac allograft survival with arachidonic acid metabolism inhibitor.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acids; Aspirin; Graft Survival; Heart Transplantation; Lysine; Male; Methacrylates; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Thromboxane B2; Thromboxanes; Transplantation, Homologous | 1987 |
Prolongation of platelet survival in hypercholesterolaemic rabbits by CGS 12970 (3-methyl-2-(3-pyridyl)-1 indoleoctanoic acid) and dazoxiben.
Topics: Animals; Aspirin; Blood Platelets; Cell Survival; Cholesterol, Dietary; Cyclooxygenase Inhibitors; Hypercholesterolemia; Imidazoles; Pyridines; Rabbits; Sulfinpyrazone; Thromboxane B2; Thromboxane-A Synthase | 1987 |
AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxycarbonyl-meth oxy coumarin) inhibits the release of arachidonic acid in human platelets stimulated by thrombin.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Chromonar; Coumarins; Diglycerides; Dose-Response Relationship, Drug; Humans; Phospholipids; Platelet Aggregation; Radioisotopes; Thrombin; Thromboxane B2 | 1987 |
Plasma thromboxane and prostacyclin metabolite ratio in atherosclerosis and diabetes mellitus.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arteriosclerosis; Aspirin; Diabetes Mellitus; Epoprostenol; Female; Humans; Male; Middle Aged; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Thromboxane B2 | 1987 |
Low dose aspirin treatment in late pregnancy differentially inhibits cyclo-oxygenase in maternal platelets.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Fetal Blood; Humans; In Vitro Techniques; Pregnancy; Pregnancy Trimester, Third; Thromboxane B2; Umbilical Arteries | 1987 |
The association of in vitro arachidonic acid responsiveness and plasma thromboxane levels with early platelet deposition on the luminal surface of small-diameter grafts.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Benzofurans; Blood Vessel Prosthesis; Dogs; Graft Occlusion, Vascular; Platelet Aggregation; Polytetrafluoroethylene; Thromboxane B2; Thromboxane-A Synthase | 1988 |
Mechanism of inhibition of cyclo-oxygenase in human blood platelets by carbamate insecticides.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Blood Proteins; Carbamates; Carbaryl; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Insecticides; Phenylcarbamates; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 1988 |
Selectivity of oral aspirin as an inhibitor of platelet vs. vascular cyclooxygenase activity is reduced by portacaval shunt in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Aspirin; Blood Platelets; Blood Vessels; Cyclooxygenase Inhibitors; Gastric Mucosa; Liver; Male; Portacaval Shunt, Surgical; Rats; Salicylates; Salicylic Acid; Thromboxane B2; Time Factors | 1988 |
Combined arachidonic acid and ADP platelet inhibition maximizes patency of small-diameter vascular grafts.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Vessel Prosthesis; Carotid Arteries; Dogs; Femoral Artery; Platelet Aggregation; Polytetrafluoroethylene; Thromboxane B2; Ticlopidine; Vascular Patency | 1988 |
Why single daily dose of aspirin may not prevent platelet aggregation.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Drug Synergism; Female; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 1988 |
Studies on the effect of long-term use of low dose aspirin in Kawasaki disease.
Topics: Adenosine Diphosphate; Aspirin; Child, Preschool; Collagen; Dose-Response Relationship, Drug; Epinephrine; Epoprostenol; Female; Humans; Male; Mucocutaneous Lymph Node Syndrome; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins; Prostaglandins F; Thromboxane A2; Thromboxane B2; Time Factors | 1988 |
Inhibition of lipoxygenase (LOX) or of cyclooxygenase (COX) improves survival of rats in endotoxin shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Cyclooxygenase Inhibitors; Disease Models, Animal; Lauric Acids; Leukocyte Count; Lipoxygenase; Lipoxygenase Inhibitors; Male; Oximes; Platelet Count; Rats; Rats, Inbred Strains; Shock, Septic; Thromboxane B2 | 1988 |
Aspirin after acute myocardial infarction: a systematic approach to compare the hemostatic effects of three different doses.
Topics: Aspirin; Bleeding Time; Blood Platelets; Hemostasis; Humans; Myocardial Infarction; Thromboxane B2 | 1985 |
Low-dose aspirin. I. Effect on angiotensin II pressor responses and blood prostaglandin concentrations in pregnant women sensitive to angiotensin II.
Topics: Angiotensin II; Aspirin; Blood Pressure; Drug Administration Schedule; Drug Resistance; Female; Humans; Hypertension; Osmolar Concentration; Parity; Pregnancy; Pregnancy Complications, Cardiovascular; Prostaglandins; Thromboxane B2 | 1988 |
Differential effects of oral administrations to human volunteers of acetylsalicylic acid, sodium salicylate and indomethacin on 12-hydroxyeicosatetraenoic acid formation by stimulated platelets.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Administration, Oral; Adult; Aspirin; Blood Platelets; Drug Administration Schedule; Female; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Male; Platelet Aggregation; Sodium Salicylate; Thromboxane B2 | 1988 |
Effects of trapidil and trapidil derivatives on arachidonic acid and prostaglandin endoperoxide analogue U 46619-induced blood pressure changes in rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 6-Ketoprostaglandin F1 alpha; Animals; Antihypertensive Agents; Aspirin; Blood Pressure; Calcium Channel Blockers; Male; Prostaglandin Endoperoxides, Synthetic; Pyrimidines; Rats; Rats, Inbred Strains; Reference Values; Thromboxane B2; Trapidil | 1988 |
Reduced mucosal prostaglandin synthesis after massive small bowel resection.
Topics: alpha-Glucosidases; Animals; Aspirin; Dinoprost; Dinoprostone; DNA; Intestinal Mucosa; Intestine, Small; Male; Postoperative Period; Prostaglandins E; Prostaglandins F; Proteins; Rats; Rats, Inbred Strains; Short Bowel Syndrome; Thromboxane B2 | 1988 |
Effects of low-dose aspirin on endogenous eicosanoid formation in normal and atherosclerotic men.
Topics: Adult; Age Factors; Arteriosclerosis; Aspirin; Epoprostenol; Humans; Male; Middle Aged; Prostaglandins E; Thromboxane B2 | 1988 |
Recovery of prostacyclin synthesis by rabbit aortic endothelium and other tissues after inhibition by aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Thoracic; Aspirin; Cycloheximide; Depression, Chemical; Endothelium; Epidermal Growth Factor; Epoprostenol; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Rabbits; Thromboxane B2 | 1987 |
Pharmacokinetics of enteric-coated aspirin and inhibition of platelet thromboxane A2 and vascular prostacyclin generation in humans.
Topics: Adult; Aspirin; Blood Platelets; Epoprostenol; Female; Humans; Kinetics; Salicylates; Salicylic Acid; Saphenous Vein; Tablets, Enteric-Coated; Thromboxane A2; Thromboxane B2 | 1987 |
Platelet-inhibitor treatment of diabetic nephropathy: a 10-year prospective study.
Topics: Adult; Aspirin; Blood Platelets; Cell Survival; Creatinine; Diabetic Nephropathies; Dipyridamole; Drug Therapy, Combination; Female; Humans; Iothalamic Acid; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Proteinuria; Thromboxane B2 | 1988 |
Low-dose enteric-coated aspirin as an antiplatelet preparation.
Topics: Adolescent; Adult; Aspirin; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation Inhibitors; Tablets, Enteric-Coated; Thromboxane B2 | 1988 |
Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study.
Topics: Adult; Aged; Albuterol; Aspirin; Asthma; Dietary Fats, Unsaturated; Docosahexaenoic Acids; Drug Combinations; Eicosapentaenoic Acid; Fatty Acids; Fatty Acids, Unsaturated; Female; Fish Oils; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Thromboxane B2 | 1988 |
Influence of antacid administrations on aspirin absorption in patients with chronic renal failure on maintenance hemodialysis.
Topics: Absorption; Adult; Aluminum Hydroxide; Antacids; Aspirin; Calcium Carbonate; Drug Administration Schedule; Drug Combinations; Drug Interactions; Female; Humans; Kidney Failure, Chronic; Magnesium Hydroxide; Male; Middle Aged; Renal Dialysis; Thromboxane B2 | 1988 |
Perioperative suppression of platelet adherence to small-diameter polytetrafluoroethylene (PTFE) grafts.
Topics: Animals; Aorta; Aspirin; Blood Vessel Prosthesis; Dipyridamole; Drug Combinations; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Polytetrafluoroethylene; Preoperative Care; Regional Blood Flow; Thromboxane B2; Vascular Patency | 1988 |
Inhibitory effect of acetylsalicylic acid on platelet function in patients with completed stroke or reversible ischemic neurologic deficit.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cerebrovascular Disorders; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation; Thromboxane B2 | 1988 |
20 mg aspirin daily--evidence for a clinical future of this extremely low-dose in arterial disease?
Topics: Adult; Arterial Occlusive Diseases; Aspirin; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation; Thromboxane B2 | 1988 |
Individual variation in platelet aggregability and serum thromboxane B2 concentrations after low-dose aspirin.
Topics: Aged; Aged, 80 and over; Aspirin; Cerebrovascular Disorders; Female; Humans; Male; Middle Aged; Platelet Aggregation; Thromboxane B2 | 1988 |
The absorption of acetylsalicylic acid from an enteric-coated formulation and the inhibition of thromboxane formation.
Topics: Adult; Aspirin; Depression, Chemical; Female; Half-Life; Humans; Intestinal Absorption; Male; Salicylates; Salicylic Acid; Tablets; Tablets, Enteric-Coated; Thromboxane B2; Thromboxanes | 1988 |
11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation.
Topics: Aspirin; Humans; Kinetics; Platelet Aggregation; Thromboxane B2; Thromboxanes; Time Factors | 1986 |
Platelet-activating factor-acether-induced relaxation of guinea pig airway muscle: role of prostaglandin E2 and the epithelium.
Topics: Acetylcholine; Animals; Aspirin; Dinoprostone; Epithelium; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Platelet Activating Factor; Prostaglandins E; Serotonin; SRS-A; Thromboxane B2; Trachea | 1987 |
Aspirin and risk of bleeding in patients with thrombocythemia.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adolescent; Adult; Aged; Aspirin; Bleeding Time; Blood Platelets; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Middle Aged; Myeloproliferative Disorders; Polycythemia Vera; Risk; Serotonin; Thrombocythemia, Essential; Thromboxane B2; Time Factors; von Willebrand Factor | 1987 |
Platelet interaction with a pancreatic ascites tumor.
Topics: Animals; Antithrombin III; Apyrase; Ascites; Aspirin; Blood Coagulation; Blood Platelets; Cricetinae; Epoprostenol; Fibrinogen; Humans; Mesocricetus; Microscopy, Electron; Pancreatic Neoplasms; Platelet Aggregation; Platelet Count; Serotonin; Thromboxane B2 | 1986 |
Rapid recovery of in vivo prostacyclin formation after inhibition by aspirin. Evidence from measurements of the major urinary metabolite of prostacyclin by GC-MS.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Epoprostenol; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Prostaglandin Antagonists; Thromboxane B2; Time Factors | 1986 |
Maternal ingestion of acetylsalicylic acid inhibits fetal and neonatal prostacyclin and thromboxane in humans.
Topics: Adult; Aspirin; Epoprostenol; Female; Fetal Blood; Humans; Infant, Newborn; Pregnancy; Thromboxane A2; Thromboxane B2; Thromboxanes | 1986 |
Effects of low doses of aspirin and dipyridamole on platelet aggregation in the dog coronary artery.
Topics: Animals; Aspirin; Coronary Circulation; Dipyridamole; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Epoprostenol; Female; Indomethacin; Male; Platelet Aggregation; Thromboxane B2 | 1987 |
Increased thromboxane B2 excretion in diabetes mellitus.
Topics: Adult; Aspirin; Blood Platelets; Diabetes Mellitus; Female; Glomerular Filtration Rate; Humans; Kidney; Male; p-Aminohippuric Acid; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1987 |
Comparison of the effect of acetylsalicylic acid on platelet function in male and female patients with ischemic stroke.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Brain Ischemia; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Salicylates; Salicylic Acid; Sex Factors; Thromboxane B2 | 1987 |
Studies of platelet hyperactivity in patients with ischemic cerebrovascular diseases: IV. Determination of the optimal dosage of aspirin by measuring plasma salicylate level.
Topics: Aged; Aspirin; Blood Platelets; Brain Ischemia; Female; Humans; Male; Middle Aged; Salicylates; Salicylic Acid; Thromboxane B2 | 1987 |
Thromboxane synthase inhibition: implications for prostaglandin endoperoxide metabolism. II. Testing the 'redirection hypothesis' in an acute intravenous challenge model.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Indoles; Kinetics; Male; Prostaglandin Endoperoxides; Rats; Rats, Inbred Strains; Thromboxane B2; Thromboxane-A Synthase | 1986 |
Low dose aspirin does not prevent fibrinolytic response to venous occlusion.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Aspirin; Fibrinolysis; Hematocrit; Humans; Isoindoles; Phenylbutyrates; Thrombosis; Thromboxane B2 | 1986 |
Mechanism of PAF-induced platelet aggregation in man.
Topics: Adult; Aspirin; Blood Platelets; Calcium Channel Blockers; Diterpenes; Female; Ginkgolides; Humans; Kinetics; Lactones; Male; Masoprocol; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Thromboxane B2; Trifluoperazine | 1986 |
Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs.
Topics: Adult; Aspirin; Blood Platelets; Humans; Imidazoles; Male; Metabolic Clearance Rate; Middle Aged; Platelet Count; Salicylates; Thromboxane A2; Thromboxane B2 | 1987 |
Platelet antagonists eliminate thromboembolic complications of small-diameter arterial prostheses.
Topics: Animals; Aspirin; Blood Vessel Prosthesis; Dipyridamole; Graft Occlusion, Vascular; Male; Platelet Aggregation; Polytetrafluoroethylene; Postoperative Complications; Rabbits; Thromboembolism; Thromboxane B2; Vascular Patency | 1987 |
Effect of aspirin on ex vivo generation of thromboxane in healthy horses.
Topics: Animals; Aspirin; Horses; Thromboxane B2 | 1987 |
Regulation of increase in anastomotic blood flow following pulmonary arterial occlusion.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arterial Occlusive Diseases; Arteriovenous Anastomosis; Aspirin; Bronchi; Dogs; Indomethacin; Pulmonary Artery; Regional Blood Flow; Thromboxane B2 | 1985 |
Differential salicylate-aspirin interaction on vascular prostacyclin and platelet thromboxane synthesis in patients undergoing saphenectomy.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Drug Interactions; Female; Humans; Middle Aged; Salicylates; Salicylic Acid; Thromboxane B2; Varicose Veins; Veins | 1985 |
Plasma concentrations and anti-platelet effects after low dose acetylsalicylic acid.
Topics: Adult; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation; Thromboxane B2; Time Factors | 1985 |
Comparison of the effects of different anti-inflammatory drugs on synovial fluid prostanoid concentrations in patients with rheumatoid arthritis.
Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Carbazoles; Diclofenac; Dinoprostone; Guanidines; Humans; Indomethacin; Naproxen; ortho-Aminobenzoates; Prednisolone; Prostaglandins; Prostaglandins E; Quinazolines; Synovial Fluid; Thromboxane B2 | 1985 |
Effects of salsalate (nonacetylated salicylate) and aspirin on serum prostaglandins in humans.
Topics: Adult; Aspirin; Dinoprostone; Humans; Male; Prostaglandins E; Salicylates; Thromboxane B2 | 1985 |
Template bleeding time and thromboxane generation in the horse: effects of three non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bleeding Time; Blood Coagulation; Clonixin; Horses; Phenylbutazone; Thromboxane B2 | 1985 |
Prostaglandins and human platelet aggregation. Implications for the anti-aggregating activity of thromboxane-synthase inhibitors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Dinoprost; Dinoprostone; Drug Synergism; Humans; Imidazoles; Oxidoreductases; Platelet Aggregation; Prostaglandin D2; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Prostaglandins D; Prostaglandins E; Prostaglandins F; Prostanoic Acids; Thromboxane B2; Thromboxane-A Synthase | 1985 |
Differential inhibition of platelet thromboxane and lung prostacyclin production by sulphinpyrazone, acetylsalicylic acid and indomethacin by human tissues in vitro.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Epoprostenol; Humans; In Vitro Techniques; Indomethacin; Lung; Sulfinpyrazone; Thromboxane A2; Thromboxane B2 | 1985 |
Amplification of primary response of human platelets to platelet-activating factor: aspirin-sensitive and aspirin-insensitive pathways.
Topics: Arachidonate Lipoxygenases; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Drug Resistance; Humans; In Vitro Techniques; Lipoxygenase Inhibitors; Platelet Activating Factor; Platelet Aggregation; Serotonin; Thromboxane B2 | 1985 |
Duration of the effect of aspirin on the synthesis of thromboxane by density subpopulations of rabbit platelets stimulated with thrombin.
Topics: Animals; Aspirin; Blood Platelets; Cell Separation; Prostaglandin-Endoperoxide Synthases; Rabbits; Thrombin; Thromboxane B2; Thromboxanes; Time Factors | 1985 |
Human platelet aggregation and release reaction induced by platelet activating factor (PAF-acether)--effects of acetylsalicylic acid and external ionized calcium.
Topics: Aspirin; Blood Platelets; Calcium Chloride; Cyclooxygenase Inhibitors; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Serotonin; Thromboxane B2 | 1985 |
Cumulative antiplatelet effect of low-dose enteric coated aspirin.
Topics: Adenosine Triphosphate; Adult; Aspirin; Bleeding Time; Blood Platelets; Dose-Response Relationship, Drug; Humans; Male; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Tablets, Enteric-Coated; Thromboxane B2 | 1985 |
Long-term ultra-low-dose aspirin therapy and platelet function.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Bleeding Time; Collagen; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Male; Platelet Aggregation; Thromboxane B2; Thromboxanes; Time Factors | 1985 |
[Effect of various stimulators on cyclooxygenase activity, platelet aggregation and TxB2 synthesis after using a platelet inhibitor (Aspro Clear) in vivo and in vitro].
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Collagen; Drug Synergism; Epinephrine; Female; Humans; In Vitro Techniques; Male; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 1985 |
Effect of incremental doses of aspirin on bleeding time, platelet aggregation and thromboxane production in patients with cerebrovascular disease.
Topics: Adult; Aged; Aspirin; Bleeding Time; Brain Ischemia; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Male; Middle Aged; Platelet Aggregation; Thrombosis; Thromboxane B2 | 1985 |
Aspirin inhibits platelet 12-hydroxy-eicosatetraenoic acid formation.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adult; Aspirin; Blood Platelets; Collagen; Depression, Chemical; Humans; Hydroxyeicosatetraenoic Acids; Male; Platelet Aggregation; Thromboxane B2 | 1986 |
Thromboxane production by perturbed bovine aortic endothelial cells in culture.
Topics: Animals; Aorta; Aspirin; Cattle; Cells, Cultured; Clone Cells; Cycloheximide; Dactinomycin; Endothelium; Endotoxins; Imidazoles; Thromboxane B2; Thromboxanes; Time Factors | 1985 |
Effect of high dose aspirin on coronary hemodynamics during pacing-induced myocardial ischemia.
Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Aspirin; Cardiac Pacing, Artificial; Coronary Circulation; Coronary Disease; Female; Hemodynamics; Humans; Lactates; Lactic Acid; Male; Middle Aged; Myocardial Infarction; Thromboxane B2; Vascular Resistance | 1985 |
Inhibition of platelet aggregation and thromboxane B2 production during aspirin treatment: dependence on the dose of the aggregating agent.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Male; Platelet Aggregation; Thromboxane B2; Thromboxanes | 1985 |
Lack of effect of glucocorticoids upon plasma thromboxane in patients in a state of shock.
Topics: Aspirin; Blood Coagulation; Glucocorticoids; Humans; Methylprednisolone; Oxygen; Oxygen Consumption; Radioimmunoassay; Shock, Septic; Thromboxane B2; Thromboxanes | 1985 |
In vitro comparison of the efficacy of cyclooxygenase inhibitors on the adult versus neonatal platelet.
Topics: Adult; Aspirin; Blood Platelets; Female; Fetal Blood; Humans; Indomethacin; Infant, Newborn; Male; Thrombin; Thromboxane B2 | 1985 |
Influence of acetylsalicylic acid on bleeding time and serum thromboxane B2 in diabetes mellitus type I.
Topics: Adolescent; Adult; Aspirin; Bleeding Time; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Female; Glycated Hemoglobin; Humans; Lipids; Male; Thromboxane B2 | 1985 |
Aspirin kinetics and inhibition of platelet thromboxane generation-relevance for a solution of the "aspirin dilemma".
Topics: Adult; Aspirin; Blood Platelets; Capsules; Humans; Kinetics; Male; Salicylates; Salicylic Acid; Tablets; Thromboxane B2 | 1985 |
Aspirin inhibition of thromboxane release in thrombosis and renal transplant rejection.
Topics: Aspirin; Graft Rejection; Humans; Kidney Transplantation; Thrombophlebitis; Thromboxane B2; Thromboxanes | 1982 |
Thromboxane A2 in skin-bleeding-time blood and in clotted venous blood before and after administration of acetylsalicylic acid.
Topics: Adenosine Diphosphate; Adult; Aspirin; Bleeding Time; England; Hemorrhage; Hemostasis; Humans; Male; Platelet Aggregation; Platelet Function Tests; Skin; Sweden; Thromboxane A2; Thromboxane B2; Thromboxanes | 1983 |
The effects of BW755C and other anti-inflammatory drugs on eicosanoid concentrations and leukocyte accumulation in experimentally-induced acute inflammation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Aspirin; Cell Movement; Dexamethasone; Dinoprostone; Exudates and Transudates; Fatty Acids, Unsaturated; Indomethacin; Inflammation; Leukocyte Count; Leukocytes; Leukotriene B4; Male; Prostaglandins E; Pyrazoles; Rats; Thromboxane B2 | 1983 |
The sex-related differences in aspirin pharmacokinetics in rabbits and man and its relationship to antiplatelet effects.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Animals; Aorta, Thoracic; Aspirin; beta-Thromboglobulin; Blood Platelets; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Endothelium; Epoprostenol; Female; Half-Life; Humans; Kinetics; Male; Platelet Aggregation; Rabbits; Sex Factors; Thromboxane B2 | 1983 |
Aspirin inhibits endogenous prostacyclin and thromboxane biosynthesis in man.
Topics: Aspirin; Humans; Kinetics; Prostaglandins F, Synthetic; Thromboxane B2; Thromboxanes | 1983 |
Evidence for a renal origin of urinary thromboxane B2 in health and disease.
Topics: Adult; Aspirin; Blood Platelets; Female; Glomerulonephritis; Humans; Kidney; Kinetics; Reference Values; Sulindac; Thromboxane B2; Thromboxanes | 1983 |
Aspirin decreases platelet uptake on Dacron vascular grafts in baboons.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Vessel Prosthesis; Carotid Arteries; Graft Survival; Indium; Male; Papio; Platelet Adhesiveness; Platelet Aggregation; Polyethylene Terephthalates; Radioisotopes; Radionuclide Imaging; Thromboxane B2; Time Factors | 1984 |
Aspirin therapy in small-caliber arterial prostheses: long-term experimental observations.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Antigens; Aspirin; Blood Platelets; Blood Vessel Prosthesis; Dogs; Epoprostenol; Factor VIII; Malondialdehyde; Platelet Aggregation; Polyethylene Terephthalates; Thromboxane A2; Thromboxane B2; Time Factors; von Willebrand Factor | 1984 |
Effects of any epoxymethano stable analogue of prostaglandin endoperoxides (U-46619) on human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Blood Platelets; Calcium; Cyclic AMP; Fibrinogen; Humans; L-Lactate Dehydrogenase; Magnesium; Malondialdehyde; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Serotonin; Thromboxane B2 | 1981 |
Strontium ions induce production of thromboxane B2 and secretion of 5-hydroxytryptamine in washed human platelets.
Topics: Aspirin; Blood Platelets; Bucladesine; Humans; Prostaglandins E; Serotonin; Strontium; Thromboxane B2; Thromboxanes | 1981 |
Effects of stimulators and inhibitors on arachidonic acid metabolism in hepatoma.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Butylated Hydroxytoluene; Carcinoma, Hepatocellular; Indomethacin; Liver Neoplasms; Prostaglandins; Rats; Sodium Salicylate; Thromboxane B2; Thromboxanes; Tryptophan | 1981 |
Evidence for the generation of hydroxyl radical during arachidonic acid metabolism by human platelets.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Carbon Dioxide; Cell Separation; Dimethyl Sulfoxide; Free Radicals; Humans; Hydroxides; Hydroxyl Radical; Thromboxane B2; Time Factors | 1981 |
Platelet aggregation and thromboxane A2 production after adrenergic stimulation in young healthy humans.
Topics: Adolescent; Adult; Aspirin; beta-Thromboglobulin; Cold Temperature; Female; Humans; Male; Platelet Aggregation; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Thromboxane A2; Thromboxane B2; Thromboxanes; Vascular Resistance | 1982 |
Evidence for a mediator role of thromboxane A2 in the myotropic action of leukotriene B4 (LTB4) on the guinea-pig lung.
Topics: Animals; Arachidonic Acids; Aspirin; Female; Flufenamic Acid; Guinea Pigs; Imidazoles; Indoles; Leukotriene B4; Leukotrienes; Lipid Peroxides; Lung; Male; Muscle Contraction; Peroxides; Prostaglandins; Pyridines; Quinacrine; Thromboxane A2; Thromboxane B2; Thromboxanes | 1982 |
Effects of dipyrone on prostaglandin production by human platelets and cultured bovine aortic endothelial cells.
Topics: Aminopyrine; Animals; Aorta; Aspirin; Blood Platelets; Blood Vessels; Cattle; Cells, Cultured; Dipyrone; Endothelium; Epoprostenol; Humans; Platelet Aggregation; Prostaglandins; Thromboxane B2 | 1983 |
Selective and nonselective inhibition of thromboxane formation.
Topics: Aspirin; Blood Platelets; Collagen; Epoprostenol; Humans; Imidazoles; Male; Pyridines; Random Allocation; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1984 |
Prostanoid synthesis by aortic rings in human blood: selective increase of prostacyclin mediated by a serum factor.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Aspirin; Citrates; Epoprostenol; Humans; In Vitro Techniques; Male; Methacrylates; Muscle, Smooth, Vascular; Prostaglandins; Radioimmunoassay; Rats; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1984 |
Conversion from chronic to acute coronary artery disease: speculation regarding mechanisms.
Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Angina, Unstable; Aorta; Aspirin; Blood Pressure; Coronary Circulation; Coronary Disease; Coronary Vessels; Epoprostenol; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Prostaglandins; Thromboxane A2; Thromboxane B2 | 1984 |
Monitoring the entry of new platelets into the circulation after ingestion of aspirin.
Topics: Adenosine Triphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Female; Humans; Male; Middle Aged; Platelet Aggregation; Thromboxane B2; Time Factors | 1983 |
Platelet malondialdehyde production kinetics after cyclooxygenase block. A study performed with a modified high sensitivity assay.
Topics: Adult; Aged; Aspirin; Blood Platelets; Cell Survival; Cyclooxygenase Inhibitors; Humans; Lung Diseases, Obstructive; Malonates; Malondialdehyde; Middle Aged; Prostaglandin-Endoperoxide Synthases; Thrombocytopenia; Thromboxane B2 | 1983 |
Role of thromboxanes in vasotonic versus vaso-occlusive angina.
Topics: Angina Pectoris; Angina Pectoris, Variant; Arterial Occlusive Diseases; Aspirin; Blood Platelets; Cardiac Pacing, Artificial; Coronary Disease; Coronary Vasospasm; Heparin; Humans; Lactates; Thromboxane B2; Thromboxanes | 1983 |
Thromboxane A2 generation by the larval cestode, Taenia taeniaeformis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Horses; Imidazoles; Indomethacin; Kinetics; Larva; Platelet Aggregation; Rats; Taeniasis; Thromboxane A2; Thromboxane B2; Thromboxanes | 1983 |
The effects of aspirin and dipyridamole on the metabolism of arachidonic acid in human platelets.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Dipyridamole; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Humans; In Vitro Techniques; Leukotrienes; Male; Thromboxane B2 | 1983 |
Effects of ASA on thromboxane and prostacyclin synthesis by rabbit aorta and pulmonary artery.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Female; In Vitro Techniques; Prostaglandins; Pulmonary Artery; Rabbits; Thromboxane A2; Thromboxane B2; Thromboxanes; Time Factors | 1983 |
Sodium salicylate interferes with the inhibitory effects of aspirin and indomethacin on human platelets.
Topics: Adult; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Humans; Indomethacin; Male; Platelet Aggregation; Sodium Salicylate; Thromboxane B2 | 1983 |
The effect of two low doses of aspirin on whole blood thromboxane and prostacyclin generation in healthy subjects.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Coagulation; Cyclooxygenase Inhibitors; Epoprostenol; Female; Humans; Male; Thromboxane B2; Thromboxanes; Time Factors | 1983 |
Sensitivity of rabbit platelet and aortic cyclooxygenase to inhibition by aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Epoprostenol; Female; In Vitro Techniques; Rabbits; Thrombosis; Thromboxane B2 | 1983 |
Recovery of cyclooxygenase activity after aspirin in populations of platelets separated on stractan density gradients.
Topics: Aspirin; Blood Platelets; Cell Separation; Cell Survival; Centrifugation, Density Gradient; Humans; In Vitro Techniques; Prostaglandin-Endoperoxide Synthases; Thromboxane B2; Time Factors | 1983 |
Unidirectional transfer of prostaglandin endoperoxides between platelets and endothelial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcimycin; Cattle; Cell Communication; Endothelium; Epoprostenol; Humans; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandins F; Thromboxane B2 | 1984 |
Maternal aspirin administration inhibits pulmonary arachidonic acid metabolism in fetal rabbits.
Topics: Animals; Arachidonic Acids; Aspirin; Chromatography, Thin Layer; Cyclooxygenase Inhibitors; Female; Fetus; Lipid Metabolism; Lung; Maternal-Fetal Exchange; Pregnancy; Rabbits; Thromboxane B2 | 1984 |
Enteric-coated aspirin, platelet cyclooxygenase activity and function.
Topics: Animals; Arachidonic Acids; Aspirin; Biological Availability; Blood Platelets; Cyclooxygenase Inhibitors; Dogs; Humans; Prostaglandin-Endoperoxide Synthases; Tablets, Enteric-Coated; Thromboxane B2; Time Factors | 1984 |
The effects of aspirin and OKY-1581 on the metabolism of exogenous arachidonic acid in rat alveolar macrophages.
Topics: Acrylates; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Dinoprost; Dinoprostone; Macrophages; Methacrylates; Oxidoreductases; Prostaglandins E; Prostaglandins F; Pulmonary Alveoli; Rats; Thromboxane B2; Thromboxane-A Synthase | 1984 |
Comparative study on the effects of acetylsalicylic acid, indomethacin and paracetamol on metabolites of arachidonic acid in plasma, serum and urine in man.
Topics: Acetaminophen; Arachidonic Acid; Arachidonic Acids; Aspirin; Dinoprostone; Humans; Indomethacin; Prostaglandins E; Thromboxane B2 | 1983 |
Macrophage-dependent arachidonate metabolism in hydronephrosis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Bradykinin; Chromatography, Thin Layer; Dinoprostone; Disease Models, Animal; Endotoxins; Hydronephrosis; Kidney Cortex; Macrophages; Male; Mechlorethamine; Microsomes; Prostaglandins E; Rabbits; Thromboxane B2; Time Factors | 1984 |
Prostaglandin endoperoxides and thromboxane A2 in thrombus formation in the hamster cheek pouch in vivo.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cheek; Cricetinae; Cyclooxygenase Inhibitors; Dipyridamole; Epoprostenol; Male; Mesocricetus; Microscopy, Electron; Platelet Aggregation; Sulfinpyrazone; Thrombosis; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1984 |
Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase.
Topics: Acetylation; Administration, Oral; Adult; Aspirin; Biological Availability; Blood Platelets; Deuterium; Dose-Response Relationship, Drug; Humans; Injections, Intravenous; Kinetics; Male; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 1984 |
Mechanism of nitroglycerin-induced coronary dilatation: lack of relation to intracoronary thromboxane concentrations.
Topics: Adult; Aged; Aspirin; Coronary Circulation; Coronary Disease; Coronary Vessels; Female; Humans; Male; Middle Aged; Nitroglycerin; Thromboxane A2; Thromboxane B2; Thromboxanes; Vasodilation | 1984 |
Spasmogenic activity of C5adesArg anaphylatoxin on guinea pig lung parenchymal strips: sensitivity of the leukotriene-mediated component to cyclooxygenase inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Complement C5; Complement C5a, des-Arginine; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Guinea Pigs; Imidazoles; Indomethacin; Lung; Muscle Contraction; Piroxicam; Prostaglandins E; Prostaglandins F; SRS-A; Thiazines; Thromboxane B2 | 1984 |
Comparative effects of some non-steroidal anti-inflammatory drugs on the ultrastructural integrity and prostaglandin levels in the rat gastric mucosa: relationship to drug uptake.
Topics: Animals; Anti-Inflammatory Agents; Apazone; Aspirin; Chromatography, Gas; Dinoprostone; Gastric Mucosa; Indomethacin; Intestinal Absorption; Kinetics; Lipoxygenase; Male; Mass Spectrometry; Microscopy, Electron; Propionates; Prostaglandins; Prostaglandins E; Rats; Rats, Inbred Strains; Thromboxane B2 | 1984 |
Urinary excretion of 2,3-dinor-thromboxane B2 in man under normal conditions, following drugs and during some pathological conditions.
Topics: Acetaminophen; Adult; Amino Acid Metabolism, Inborn Errors; Aspirin; Circadian Rhythm; Diabetes Mellitus; Female; Humans; Indomethacin; Male; Myocardial Infarction; Physical Exertion; Pregnancy; Reference Values; Thromboxane B2; Thromboxanes | 1984 |
Platelet activity in relation to smoke and exercise in patients with chronic obstructive lung disease: effects of platelet antiaggregating drugs.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Blood Platelets; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Physical Exertion; Platelet Aggregation; Smoking; Thromboxane B2 | 1984 |
Effect of TEI-4120 (3-benzoyl-N-beta-ethoxyisopropyl-2-methlindole) on carrageenan induced disseminated intravascular coagulation (DIC) in rats.
Topics: Animals; Aspirin; Bleeding Time; Carrageenan; Disseminated Intravascular Coagulation; Fibrinolytic Agents; Hemodynamics; Heparin; Indoles; Male; Rats; Rats, Inbred Strains; Thromboxane B2; Warfarin | 1984 |
Plasmatic TXB2 and 6-keto-PGF1 alpha levels during charcoal hemoperfusion in chronic renal failure patients.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Charcoal; Hemoperfusion; Heparin; Humans; Kidney Failure, Chronic; Middle Aged; Platelet Count; Thromboxane B2; Thromboxanes | 1983 |
Effect of prolonged treatment with acetylsalicylic acid and dipyridamole on platelet thromboxane A2 production in atherosclerotic subjects.
Topics: Aged; Arteriosclerosis; Aspirin; Blood Platelets; Dipyridamole; Female; Humans; Kinetics; Male; Thromboxane A2; Thromboxane B2; Thromboxanes | 1983 |
Manipulation of the local thromboxane and prostacyclin balance in vivo by the antithrombotic compounds dazoxiben, acetylsalicylic acid and nafazatrom.
Topics: Animals; Aspirin; Dinoprost; Drug Interactions; Fibrinolytic Agents; Functional Laterality; Imidazoles; Kinetics; Male; Prostaglandins F; Pyrazoles; Pyrazolones; Rabbits; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1983 |
Salicylate does not interfere with aspirin in human blood in vivo.
Topics: Adult; Aspirin; Blood Coagulation; Blood Platelets; Humans; Male; Salicylates; Salicylic Acid; Thromboxane B2; Thromboxanes | 1984 |
Spasmogenic properties of platelet-activating factor: evidence for a direct mechanism in the contractile response of pulmonary tissues.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aspirin; Blood Platelets; Catechols; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Lung; Masoprocol; Muscle Contraction; Muscle, Smooth; Platelet Activating Factor; Rats; Sulfinpyrazone; Thromboxane B2 | 1983 |
Thromboxane production in the pregnant rat: differential recovery by platelets and uterus following aspirin administration.
Topics: Animals; Aspirin; Blood Platelets; Female; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Thromboxane B2; Thromboxanes; Uterus | 1983 |
Thromboxane synthesis by sources other than platelets in association with complement-induced pulmonary leukostasis and pulmonary hypertension in sheep.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Platelets; Complement Activation; Female; Hypertension, Pulmonary; In Vitro Techniques; Leukocytes; Lung; Male; Pulmonary Artery; Sheep; Thrombocytopenia; Thromboxane B2; Thromboxanes | 1983 |
Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with dazoxiben hydrochloride (UK 37,248-01).
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Platelets; Electric Stimulation; Imidazoles; Indium; Male; Oxidoreductases; Rabbits; Radioisotopes; Thrombosis; Thromboxane B2; Thromboxane-A Synthase | 1983 |
The involvement of prostaglandins and thromboxanes in the response to pulmonary embolism in anaesthetized rabbits and isolated perfused lungs.
Topics: 6-Ketoprostaglandin F1 alpha; Anesthesia, General; Animals; Aspirin; Hypotension; Indomethacin; Lung; Male; Perfusion; Pressure; Pulmonary Artery; Pulmonary Embolism; Rabbits; Thromboxane B2; Thromboxanes | 1983 |
Studies on the beneficial effects of aspirin in endotoxic shock. Relationship to inhibition of arachidonic acid metabolism.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acids; Aspirin; Blood Platelets; Fibrin Fibrinogen Degradation Products; Macrophages; Male; Radioimmunoassay; Rats; Shock, Septic; Thromboxane B2 | 1983 |
Urinary excretion of thromboxane B2 in patients with venous thromboembolic disease.
Topics: Angiography; Aspirin; Humans; Lung; Platelet Function Tests; Pulmonary Embolism; Radioimmunoassay; Thrombophlebitis; Thromboxane B2; Thromboxanes | 1984 |
Recovery of megakaryocyte thromboxane production in vitro after aspirin inhibition.
Topics: Animals; Aspirin; Blood Platelets; Cells, Cultured; Guinea Pigs; Kinetics; Megakaryocytes; Radioimmunoassay; Thromboxane B2; Thromboxanes | 1984 |
Plasma levels of salicylate and aspirin in healthy volunteers: relevance to drug interaction on platelet function.
Topics: Adult; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Drug Interactions; Humans; Male; Platelet Aggregation; Salicylates; Sodium Salicylate; Thromboxane B2; Time Factors | 1984 |
Activation of platelet prostaglandin biosynthesis pathway during neoplastic cell-induced platelet aggregation.
Topics: Animals; Apyrase; Aspirin; Blood Platelets; Cell Line; Cell Transformation, Neoplastic; Fibrosarcoma; Humans; Mice; Platelet Aggregation; Thromboxane B2; Thromboxanes | 1984 |
A study of the bioavailability and platelet inhibitory effects of a new enteric-coated acetylsalicylic acid preparation.
Topics: Aspirin; Biological Availability; Blood Platelets; Collagen; Female; Humans; Male; Tablets, Enteric-Coated; Thromboxane B2; Thromboxanes | 1984 |
Bleeding time in rats: a comparison of different experimental conditions.
Topics: Anesthetics; Animals; Aspirin; Bleeding Time; Blood Coagulation; Blood Platelet Disorders; Dipyridamole; Disease Models, Animal; Epoprostenol; Heparin; Indomethacin; Rats; Tail; Thromboxane B2 | 1982 |
Aspirin, prostacyclin and post-occlusive reactive hyperaemia in man.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Epoprostenol; Humans; Hyperemia; Male; Prostaglandins; Thromboxane B2 | 1982 |
Prostacyclin production in rabbit arteries in situ: inhibition by arachidonic acid-induced endothelial cell damage or by low-dose aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Arteries; Aspirin; Ear; Endothelium; Epoprostenol; Male; Prostaglandins; Prostaglandins F; Rabbits; Thromboxane B2 | 1981 |
Non-steroidal anti-inflammatory drugs react with two sites on platelet cyclo-oxygenase. Evidence from "in vivo" drug interaction studies in rats.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Binding Sites; Blood Platelets; Kinetics; Male; Malondialdehyde; Prostaglandin-Endoperoxide Synthases; Protein Binding; Rats; Sodium Salicylate; Thromboxane B2 | 1982 |
Variables associated with radioimmunoassay of prostaglandins in plasma.
Topics: Aspirin; Edetic Acid; False Positive Reactions; Humans; Indomethacin; Prostaglandins; Radioimmunoassay; Specimen Handling; Thromboxane B2 | 1981 |
Arachidonic acid induces human platelet-fibrin retraction: the role of platelet cyclic endoperoxides.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alprostadil; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Clot Retraction; Epoprostenol; Fatty Acids, Unsaturated; Fibrin; Humans; Imidazoles; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins D; Prostaglandins E; Prostaglandins H; Prostaglandins, Synthetic; Thromboxane B2 | 1982 |
Human platelet activation in the absence of aggregation: a calcium-dependent phenomenon independent of thromboxane formation.
Topics: Aspirin; Blood Platelets; Calcimycin; Calcium; Humans; Microscopy, Electron; Platelet Aggregation; Platelet Count; Serotonin; Thromboxane B2; Thromboxanes | 1982 |
Aspirin inhibits rat megakaryocyte thromboxane synthesis.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Humans; Megakaryocytes; Radioimmunoassay; Rats; Rats, Inbred Strains; Thromboxane B2; Thromboxanes | 1982 |
Effect of acetaminophen and salicylate on aspirin-induced inhibition of human platelet cyclo-oxygenase.
Topics: Acetaminophen; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Humans; Salicylates; Thromboxane B2 | 1982 |
The facilitating effects of adrenaline on platelet aggregation.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Drug Synergism; Epinephrine; Humans; Platelet Aggregation; Radioimmunoassay; Thromboxane B2 | 1982 |
Effect of acetylsalicylic acid on platelet aggregation and thromboxane B2 production in flowing aortic blood in the rat studied with a filter loop technique.
Topics: Adenosine Diphosphate; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Aspirin; Male; Methods; Platelet Aggregation; Rats; Rats, Inbred Strains; Salicylates; Thromboxane B2; Thromboxanes | 1982 |
Low-dose aspirin inhibits platelet and venous cyclo-oxygenase in man.
Topics: Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Epoprostenol; Female; Forearm; Humans; Male; Prostaglandin-Endoperoxide Synthases; Thromboxane B2; Veins | 1982 |
Platelet activating factor (PAF) causes human platelet aggregation through the mechanism of membrane modulation.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cell Membrane; Epinephrine; Epoprostenol; Humans; Platelet Activating Factor; Platelet Aggregation; Thromboxane B2; Time Factors | 1982 |
Comparison of umbilical vein models for measurement of relative prostacyclin and thromboxane production.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Arachidonic Acids; Aspirin; Epoprostenol; Humans; Methacrylates; Models, Biological; Prostaglandins; Specimen Handling; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes; Umbilical Veins | 1982 |
Aspirin usage and perioperative blood loss in patients undergoing unexpected operations.
Topics: Arachidonic Acids; Aspirin; Bleeding Time; Blood Coagulation; Blood Platelets; Hemorrhage; Humans; Intraoperative Period; Surgical Procedures, Operative; Thromboxane B2; Time Factors | 1983 |
Aspirin, prostaglandins, and peripheral gangrene.
Topics: Adult; Aged; Aspirin; Blood Platelets; Female; Gangrene; Humans; Male; Middle Aged; Platelet Aggregation; Prostaglandins; Thrombocytosis; Thromboxane B2; Time Factors; Toes; Veins | 1983 |
Changes in the levels of prostaglandins and thromboxane and their roles in the accumulation of exudate in rat carrageenin-induced pleurisy--a profile analysis using gas chromatography-mass spectrometry.
Topics: Animals; Aspirin; Carrageenan; Gas Chromatography-Mass Spectrometry; Imidazoles; Male; Pleurisy; Prostaglandins; Rats; Rats, Inbred Strains; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1982 |
Protective effects of aspirin in endotoxic shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Glucose; Fibrin Fibrinogen Degradation Products; Lysosomes; Male; Platelet Aggregation; Prostaglandins F; Rats; Shock, Septic; Thromboxane B2 | 1981 |
Comparative effects of acetylsalicylic acid (ASA) and sulfinpyrazone on isoproterenol-induced heart damage.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Urea Nitrogen; Creatine Kinase; Isoproterenol; Male; Myocardial Infarction; Prostaglandins F; Rats; Sulfinpyrazone; Thromboxane B2 | 1981 |
Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with thromboxane synthetase inhibitor dazoxiben hydrochloride, (UK-37, 248-01).
Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Aspirin; Carotid Artery Thrombosis; Cells, Cultured; Enzyme Inhibitors; Fibrinolytic Agents; Imidazoles; In Vitro Techniques; Oxidoreductases; Platelet Aggregation; Rabbits; Thromboxane B2; Thromboxane-A Synthase | 1982 |
Significance of platelet function and thromboxane B2 levels across the human myocardial vascular bed.
Topics: Arteriosclerosis; Aspirin; Coronary Circulation; Coronary Disease; Coronary Vessels; Dipyridamole; Humans; Platelet Aggregation; Propranolol; Tachycardia; Thromboxane B2; Thromboxanes | 1981 |
Recent concepts on platelet function and dietary lipids in coronary thrombosis, vasospasm and angina.
Topics: Angina Pectoris; Arachidonic Acids; Aspirin; Constriction, Pathologic; Coronary Disease; Dietary Fats; Epoprostenol; Fatty Acids, Unsaturated; Fish Oils; Humans; Platelet Aggregation; Risk; Thromboxane B2 | 1980 |
Activation of guinea-pig platelets induced by convulxin, a substance extracted from the venom of Crotalus durissus cascavella.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Blood Platelets; Crotalid Venoms; Epoprostenol; Guinea Pigs; In Vitro Techniques; Indomethacin; Lectins, C-Type; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1980 |
Humoral heartache -- do platelets have a role?
Topics: Angina Pectoris; Angina Pectoris, Variant; Animals; Aspirin; Blood Platelets; Coronary Circulation; Dogs; Epoprostenol; Humans; Indomethacin; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Thromboxanes | 1981 |
Prostaglandins and platelet aggregation.
Topics: Alprostadil; Animals; Arteries; Aspirin; Blood Platelets; Cattle; Epoprostenol; Humans; Platelet Aggregation; Prostaglandin D2; Prostaglandins; Prostaglandins D; Prostaglandins E; Thromboxane B2 | 1981 |
Role of prostaglandins in positive end-expiratory pressure-induced negative inotropism.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Dogs; Female; Hemodynamics; Imidazoles; Indomethacin; Male; Myocardial Contraction; Positive-Pressure Respiration; Prostaglandins; Thromboxane B2 | 1981 |
Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Male; Prostaglandins E; Prostaglandins F; Renin; Thromboxane B2; Thromboxanes | 1982 |
Sex related differences in platelet function: the effect of aspirin.
Topics: Animals; Aspirin; Blood Platelets; Collagen; Female; Fibrinolytic Agents; Male; Platelet Aggregation; Platelet Count; Rabbits; Sex Factors; Sodium Salicylate; Thromboxane B2 | 1982 |
Aspirin inhibits platelet function independent of the acetylation of cyclo-oxygenase.
Topics: Acetylation; Adenosine Diphosphate; Animals; Aspirin; Bleeding Time; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Oxygenases; Platelet Aggregation; Rabbits; Serotonin; Thromboxane B2 | 1982 |
Failure of thromboxane A2 blockade to prevent attacks of vasospastic angina.
Topics: Adult; Aspirin; Coronary Disease; Coronary Vasospasm; Electrocardiography; Humans; Male; Middle Aged; Thromboxane A2; Thromboxane B2; Thromboxanes | 1982 |
Dosage frequency for suppression of platelet function by low dose aspirin therapy.
Topics: Adenosine Diphosphate; Aspirin; Cell Survival; Collagen; Depression, Chemical; Dose-Response Relationship, Drug; Epinephrine; Humans; Malondialdehyde; Platelet Aggregation; Platelet Function Tests; Thrombosis; Thromboxane B2 | 1982 |
Adrenaline and PAF-acether synergize to trigger cyclooxygenase-independent activation of plasma-free human platelets.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Aspirin; Creatine Kinase; Drug Synergism; Epinephrine; Humans; Phosphocreatine; Platelet Activating Factor; Platelet Aggregation; Rabbits; Stimulation, Chemical; Thromboxane B2 | 1982 |
The relationship between the production of thromboxane B2 and malondialdehyde by human blood platelets.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Humans; In Vitro Techniques; Malonates; Malondialdehyde; Platelet Aggregation; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1980 |
Effects of very low versus standard dose acetyl salicylic acid, dipyridamole and sulfinpyrazone on platelet function and thromboxane formation in man.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Dipyridamole; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation; Sulfinpyrazone; Thromboxane B2; Thromboxanes | 1981 |
Preservation of platelets during extracorporeal circulation in sheep. A comparison between aspirin and sulfinpyrazone.
Topics: Animals; Aspirin; Blood Platelets; Blood Preservation; Blood Pressure; Extracorporeal Circulation; Leukocyte Count; Oxygenators; Platelet Count; Pulmonary Artery; Sheep; Sulfinpyrazone; Thromboxane B2 | 1981 |
Differential effects of itanoxone--a new hypolipidemic and hypouricemic drug--on platelet and vascular prostaglandin generation in rats.
Topics: Animals; Aspirin; Biphenyl Compounds; Blood Platelets; Blood Vessels; Butyrophenones; Dose-Response Relationship, Drug; Hypolipidemic Agents; Male; Malondialdehyde; Prostaglandins; Rats; Thromboxane B2; Uricosuric Agents | 1981 |
Evidence that platelet buoyant density, but not size, correlates with platelet age in man.
Topics: Adult; Aspirin; Blood Platelets; Cell Survival; Centrifugation; Chromium Radioisotopes; Galactans; Hemostasis; Humans; Male; Thromboxane B2 | 1981 |
Aspirin inhibits the early myocardial release of thromboxane B2 and ventricular ectopic activity following acute coronary artery occlusion in dogs.
Topics: Animals; Arrhythmias, Cardiac; Aspirin; Coronary Disease; Dogs; Myocardium; Thromboxane B2; Thromboxanes | 1981 |
Plasma concentrations of thromboxane B2 in patients with hypertension or cerebrovascular disease.
Topics: Adolescent; Adult; Aged; Arteries; Aspirin; Cerebrovascular Disorders; Female; Humans; Hypertension; Jugular Veins; Male; Middle Aged; Thromboxane B2; Thromboxanes; Veins | 1981 |
Clinical response and serum prostaglandin levels in aspirin idiosyncrasy. Effect of aspirin and a new nonsteroidal anti-inflammatory agent.
Topics: Adult; Anti-Inflammatory Agents; Aspirin; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Prostaglandins; Prostaglandins E; Prostaglandins F; Respiratory Function Tests; Steroids; Thromboxane B2 | 1981 |
Heparin-induced thrombocytopenia: effect of heparin platelet antibody on platelets.
Topics: Adenosine Diphosphate; Adult; Antibodies; Aspirin; Blood Platelets; Complement Fixation Tests; Dipyridamole; Female; Heparin; Humans; Indomethacin; Male; Malondialdehyde; Middle Aged; Platelet Aggregation; Platelet Factor 3; Thrombocytopenia; Thromboxane B2 | 1981 |
Platelet aggregation induced by arachidonic acid and thromboxane generation in patients with hypertension or cerebrovascular disease.
Topics: Adolescent; Adult; Aged; Arachidonic Acids; Aspirin; Blood Platelets; Brain Ischemia; Female; Humans; Hypertension; In Vitro Techniques; Male; Middle Aged; Platelet Aggregation; Prostaglandins H; Thromboxane B2; Thromboxanes | 1981 |
Changes of prostaglandin and thromboxane levels in pleural fluid of rat carrageenin-induced pleurisy.
Topics: Animals; Aspirin; Butylated Hydroxytoluene; Carrageenan; Disease Models, Animal; Imidazoles; Inflammation; Pleural Effusion; Pleurisy; Prostaglandin Endoperoxides; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Thromboxane B2; Thromboxanes | 1980 |
Radioimmunoassay of serum thromboxane B2: a simple method of assessing pharmacologic effects on platelet function.
Topics: Aspirin; Blood Coagulation; Blood Platelets; Cross Reactions; Diflunisal; Dipyridamole; Humans; Platelet Aggregation; Radioimmunoassay; Thromboxane B2; Thromboxanes | 1980 |
Influence of epinephrine on the aggregation response of aspirin-treated platelets.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Blood Platelets; Epinephrine; Humans; Platelet Aggregation; Serotonin; Thrombin; Thromboxane B2 | 1980 |
Thromboxane B2 and 6-keto-prostaglandin F1 alpha synthesis during infusion of collagen and arachidonic acid in rabbits: inhibition by aspirin and sulfinpyrazone.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Pressure; Collagen; Dose-Response Relationship, Drug; Female; Platelet Aggregation; Platelet Count; Prostaglandins F; Rabbits; Sulfinpyrazone; Thromboxane B2; Thromboxanes | 1980 |
Thromboxane generation in patients with essential hypertension or cerebrovascular disease and effect of oral aspirin.
Topics: Adolescent; Adult; Aged; Arachidonic Acids; Aspirin; Blood Platelets; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Male; Middle Aged; Prostaglandins H; Thromboxane B2; Thromboxanes | 1980 |
Thromboxane B2 (TxB2) release during IgE anaphylaxis in the rabbit.
Topics: Anaphylaxis; Animals; Aspirin; Basophils; Blood Platelets; Female; Guinea Pigs; Horseradish Peroxidase; Immunoglobulin E; Male; Neutrophils; Platelet Factor 4; Rabbits; Thromboxane B2; Thromboxanes | 1980 |
Impaired thromboxane production by newly formed platelets after aspirin administration to thrombocytopenic rats.
Topics: Animals; Aspirin; Blood Platelets; Male; Malondialdehyde; Platelet Count; Rats; Thrombocytopenia; Thromboxane B2; Thromboxanes; Time Factors | 1980 |
Platelet recovery from aspirin inhibition in vivo; differing patterns under various assay conditions.
Topics: Aspirin; Blood Platelets; Cell Survival; Centrifugation; Chromium Radioisotopes; Ethylmaleimide; Humans; Malondialdehyde; Thrombin; Thromboxane B2 | 1981 |
Measurement of thromboxane B2 in human plasma or serum by radioimmunoassay.
Topics: Aspirin; Blood Platelets; Blood Specimen Collection; Female; Humans; Platelet Aggregation; Radioimmunoassay; Temperature; Thromboxane B2; Thromboxanes | 1980 |
The effect of aspirin and indomethacin on prostacyclin and thromboxane production by placental tissue incubated with immunoglobulin G fractions from patients with lupus anticoagulant.
Topics: Antibodies, Antiphospholipid; Aspirin; Epoprostenol; Female; Humans; Immunoglobulin G; Indomethacin; Kinetics; Lupus Coagulation Inhibitor; Placenta; Pregnancy; Thromboxane B2 | 1995 |
Prostaglandin D2 and endothelin-1 induce the production of prostaglandin F2 alpha, 9 alpha, 11 beta-prostaglandin F2, prostaglandin E2, and thromboxane in capillary endothelium of human brain.
Topics: 1-Methyl-3-isobutylxanthine; Aspirin; Brain; Capillaries; Cells, Cultured; Dexamethasone; Dinoprost; Dinoprostone; Endothelins; Endothelium, Vascular; Humans; Indomethacin; Prostaglandin D2; Thromboxane B2 | 1993 |
Stimulation of glycogen phosphorylase in rat hepatocytes via prostanoid release from Kupffer cells by recombinant rat anaphylatoxin C5a but not by native human C5a in hepatocyte/Kupffer cell co-cultures.
Topics: Acetylglucosaminidase; Animals; Aspirin; Cells, Cultured; Coculture Techniques; Complement C5a; Kupffer Cells; Liver; Male; Norepinephrine; Phosphorylases; Prostaglandins; Rats; Rats, Wistar; Recombinant Proteins; Thromboxane A2; Thromboxane B2 | 1995 |
Inhibition of monocyte leukotriene B4 production after aspirin desensitization.
Topics: Adult; Aspirin; Asthma; Desensitization, Immunologic; Female; Humans; Leukotriene B4; Leukotriene C4; Male; Middle Aged; Monocytes; Thromboxane B2 | 1995 |
Implications of the prognostic importance of exercise-induced thromboxane formation in survivors of an acute myocardial infarction.
Topics: 6-Ketoprostaglandin F1 alpha; Adrenergic beta-Antagonists; Adult; Aged; Aspirin; Epoprostenol; Exercise; Exercise Test; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Myocardial Infarction; Prognosis; Thromboxane A2; Thromboxane B2 | 1995 |
Characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases.
Topics: Adult; Aspirin; Blood Platelets; Female; Humans; Lipopolysaccharides; Male; Middle Aged; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Thromboxane B2; Time Factors | 1995 |
Arterial wall rather than platelets is responsible for diminished thrombogenicity during isradipine therapy.
Topics: Animals; Arteries; Aspirin; Blood Platelets; Endothelium, Vascular; Epoprostenol; Humans; In Vitro Techniques; Indium Radioisotopes; Isradipine; Male; Perfusion; Rabbits; Thrombosis; Thromboxane B2 | 1995 |
Amelioration of radiation nephropathy by acetylsalicylic acid.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Female; Kidney Diseases; Kidney Function Tests; Mice; Mice, Inbred C3H; Radiation Injuries, Experimental; Rats; Thromboxane B2; X-Rays | 1995 |
Cyclooxygenase-dependent formation of the isoprostane 8-epi prostaglandin F2 alpha.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Aspirin; Blood Platelets; Dinoprost; Humans; Hydroxyeicosatetraenoic Acids; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 1994 |
Salicylamide reverses the aspirin-antagonistic effect of salicylic acid on rat platelet cyclooxygenase.
Topics: Animals; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Salicylamides; Salicylates; Salicylic Acid; Thromboxane B2 | 1994 |
Effect of intraventricular haemorrhage and rebleeding following subarachnoid haemorrhage on CSF eicosanoids.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Brain Damage, Chronic; Cerebral Ventricles; Dexamethasone; Dinoprost; Dinoprostone; Drug Therapy, Combination; Eicosanoids; Humans; Infusions, Intravenous; Intracranial Aneurysm; Nimodipine; Prognosis; Recurrence; Reference Values; Subarachnoid Hemorrhage; Thromboxane B2 | 1994 |
Synthesis and inhibitory effects of 1,4,5-trialkyl-2-thioimidazole derivatives on platelet aggregation.
Topics: Aspirin; Humans; Imidazoles; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 1994 |
Risk factors for carotid atherosclerosis and platelet activation.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Arteriosclerosis; Aspirin; Carotid Artery Diseases; Female; Humans; Hypercholesterolemia; Male; Middle Aged; Multivariate Analysis; Platelet Activation; Risk Factors; Smoking; Thromboxane B2 | 1994 |
In vitro and ex vivo effects of aspirin in patients on a low-dose aspirin therapy.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Collagen; Coronary Disease; Humans; Middle Aged; Platelet Aggregation; Thromboxane B2 | 1993 |
Effects of acetylsalicylic acid on pulmonary vascular tone and membrane permeability in blood-perfused dog lung.
Topics: 6-Ketoprostaglandin F1 alpha; Airway Resistance; Animals; Aspirin; Blood Pressure; Capillary Permeability; Dogs; Extravascular Lung Water; Female; Leukotrienes; Male; Muscle, Smooth, Vascular; Organ Size; Perfusion; Pulmonary Circulation; Salicylates; Salicylic Acid; Thromboxane B2; Vascular Resistance | 1993 |
Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis.
Topics: Adolescent; Adult; Arthritis, Juvenile; Aspirin; Child; Gas Chromatography-Mass Spectrometry; Humans; Leukotriene C4; Leukotriene D4; Leukotriene E4; Thromboxane B2 | 1994 |
Norepinephrine-induced human platelet activation in vivo is only partly counteracted by aspirin.
Topics: Adult; Aspirin; beta-Thromboglobulin; Exercise; Humans; Male; Norepinephrine; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Premedication; Sympathetic Nervous System; Thromboxane B2 | 1994 |
Low dose aspirin in pregnancy: a clinical and biochemical study of effects on the newborn.
Topics: Aspirin; Birth Weight; Cerebral Hemorrhage; Female; Fetal Blood; Fetal Growth Retardation; Gestational Age; Humans; Hypertension; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications, Cardiovascular; Reference Values; Thromboxane B2 | 1993 |
Peroxide induces vasoconstriction in the human placenta by stimulating thromboxane.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Aspirin; Female; Humans; Organ Culture Techniques; Oxidants; Peroxides; Placenta; Pregnancy; tert-Butylhydroperoxide; Thromboxane B2; Vasoconstriction | 1993 |
Effect of policosanol on cerebral ischemia in Mongolian gerbils: role of prostacyclin and thromboxane A2.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Brain Ischemia; Drug Synergism; Epoprostenol; Fatty Alcohols; Gerbillinae; Thromboxane A2; Thromboxane B2 | 1993 |
Rapid, direct enzyme immunoassay of 11-keto-thromboxane B2 in urine, validated by immunoaffinity/gas chromatography-mass spectrometry.
Topics: Aspirin; Cardiopulmonary Bypass; False Negative Reactions; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Immunoenzyme Techniques; Platelet Activation; Quality Control; Sensitivity and Specificity; Thromboxane B2 | 1993 |
Beneficial effects of combined thromboxane synthase inhibition/receptor blockade with CGS 22652 in a canine model of coronary thrombosis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Caprylates; Coronary Circulation; Coronary Thrombosis; Dinoprostone; Dogs; Hemodynamics; Indoles; Male; Myocardial Reperfusion; Phenylacetates; Platelet Activation; Platelet Aggregation Inhibitors; Pyridines; Receptors, Thromboxane; Streptokinase; Sulfonamides; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1993 |
Influence of aspirin on human megakaryocyte prostaglandin synthesis.
Topics: Aspirin; Bone Marrow Cells; Humans; In Vitro Techniques; Megakaryocytes; Thrombin; Thromboxane B2 | 1993 |
Urinary excretion and origin of 11-dehydro-2,3-dinor-thromboxane B2 in man.
Topics: Adult; Aspirin; Blood Platelets; Humans; Male; Reference Values; Smoking; Thromboxane B2; Thromboxanes | 1993 |
Mechanisms of platelet aggregation by Streptococcus sanguis, a causative organism in infective endocarditis.
Topics: Agglutination; Aspirin; Blood Platelets; Cells, Cultured; Endocarditis, Bacterial; Humans; Platelet Aggregation; Serotonin; Streptococcal Infections; Streptococcus sanguis; Thrombasthenia; Thromboxane B2; von Willebrand Diseases | 1993 |
Transdermal modification of platelet function. A dermal aspirin preparation selectively inhibits platelet cyclooxygenase and preserves prostacyclin biosynthesis.
Topics: Administration, Cutaneous; Adult; Aspirin; Blood Platelets; Bradykinin; Cyclooxygenase Inhibitors; Epoprostenol; Female; Humans; Male; Middle Aged; Salicylates; Salicylic Acid; Thromboxane B2 | 1993 |
U 46619 induces different blood pressure effects in male and female spontaneously hypertensive rats (SHR).
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Administration, Oral; Animals; Aorta; Aspirin; Blood Pressure; Drug Synergism; Female; Injections, Intravenous; Male; Prostaglandin Endoperoxides, Synthetic; Prostaglandins F; Rats; Rats, Inbred SHR; Thromboxane B2; Vasoconstrictor Agents | 1993 |
Platelet-derived growth factor release and antiplatelet treatment with low-dose acetylsalicylic acid.
Topics: Adult; Aspirin; beta-Thromboglobulin; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Humans; Male; Platelet-Derived Growth Factor; Stimulation, Chemical; Thromboxane B2; Time Factors | 1993 |
Arachidonic acid metabolism by isolated and cultured middle ear epithelial cells from the chinchilla.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acids; Aspirin; Cell Separation; Cells, Cultured; Chinchilla; Dinoprost; Dinoprostone; Ear, Middle; Epithelial Cells; Epithelium; Indomethacin; Prostaglandin D2; Thromboxane B2; Time Factors; Tritium | 1993 |
Cysteinyl leukotrienes overproduction and mast cell activation in aspirin-provoked bronchospasm in asthma.
Topics: Adult; Aspirin; Asthma; Blood Proteins; Bronchial Provocation Tests; Bronchoconstriction; Chymases; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Leukotriene E4; Male; Mast Cells; Methacholine Chloride; Middle Aged; Ribonucleases; Serine Endopeptidases; SRS-A; Thromboxane B2; Tryptases | 1993 |
Reduction by arachidonic acid of prostaglandin I2-induced cyclic AMP formation. Involvement of prostaglandins E2 and F2 alpha.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Colforsin; Cyclic AMP; Dinoprost; Dinoprostone; Drug Interactions; Epoprostenol; Humans; Pentanoic Acids; Platelet Aggregation; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Pyridines; Thromboxane B2 | 1993 |
Aspirin effect on early and late changes in acute lung injury in sheep.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Aspirin; Blood Gas Analysis; Hemodynamics; Least-Squares Analysis; Lung; Lung Diseases; Oleic Acid; Oleic Acids; Premedication; Pulmonary Gas Exchange; Respiration; Sheep; Thromboxane B2 | 1993 |
Increased in vivo production of thromboxane in patients with sickle cell disease is accompanied by an impairment of platelet functions to the thromboxane A2 agonist U46619.
Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Anemia, Sickle Cell; Aspirin; Blood Platelets; Female; Humans; Male; Phosphorylation; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxane A2; Thromboxane B2 | 1993 |
Thin layer chromatographic identification of thromboxane B2 in serum, and platelet rich plasma stimulated by arachidonic acid and collagen.
Topics: Adult; Arachidonic Acid; Aspirin; Blood Platelets; Chromatography, Thin Layer; Collagen; Female; Humans; Male; Middle Aged; Platelet Count; Thromboxane B2 | 1993 |
Lipopolysaccharide-induced expression of prostaglandin H synthase-2 in alveolar macrophages is inhibited by dexamethasone but not by aspirin.
Topics: Animals; Aspirin; Bronchoalveolar Lavage Fluid; Dexamethasone; Female; Gene Expression; In Vitro Techniques; Lipopolysaccharides; Macrophages, Alveolar; Prostaglandin-Endoperoxide Synthases; Rabbits; RNA, Messenger; Thromboxane B2 | 1993 |
Improved assay for the quantification of 11-dehydrothromboxane B2 by gas chromatography-mass spectrometry.
Topics: Aspirin; Chromatography, Thin Layer; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Prostaglandin D2; Solvents; Thromboxane B2 | 1993 |
Importance of secondary TXA2 release in mediating of endothelin-1 induced bronchoconstriction and vasopressin in the guinea-pig.
Topics: Animals; Aspirin; Blood Pressure; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Endothelins; Guinea Pigs; Imidazoles; Male; Naphthalenes; Prostaglandin-Endoperoxide Synthases; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Vasopressins | 1993 |
The influence of aspirin on plasma and platelet catecholamine levels, and platelet function in normal man.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Catecholamines; Collagen; Epinephrine; Female; Humans; Male; Norepinephrine; Platelet Aggregation; Platelet Function Tests; Thromboxane B2 | 1993 |
Platelet adhesivity to subendothelium is influenced by polymorphonuclear leukocytes: studies with aspirin and salicylate.
Topics: 6-Ketoprostaglandin F1 alpha; Alprostadil; Animals; Aspirin; Blood Platelets; Cell Communication; Cyclooxygenase Inhibitors; Endothelium, Vascular; Humans; Lipoxygenase Inhibitors; Neutrophils; Platelet Adhesiveness; Rabbits; Salicylates; Salicylic Acid; Thromboxane B2 | 1993 |
Effects of aspirin DL-lysine on thrombin generation in unstable angina pectoris.
Topics: Aged; Aged, 80 and over; Angina, Unstable; Antithrombin III; Aspirin; Blood Coagulation; Female; Humans; Lysine; Male; Middle Aged; Peptide Hydrolases; Platelet Aggregation Inhibitors; Thrombin; Thromboxane B2 | 1993 |
Prevention of experimental hepatic metastasis with thromboxane synthase inhibitor.
Topics: Animals; Aspirin; Colonic Neoplasms; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Liver Neoplasms, Experimental; Male; Methacrylates; Mice; Mice, Inbred C57BL; Prostaglandins F; Thromboxane B2; Thromboxane-A Synthase | 1995 |
Oesophagostomum dentatum: population dynamics and synthesis of prostanoids by histotropic stages cultured in vitro.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Female; Indomethacin; Larva; Male; Morphogenesis; Oesophagostomum; Prostaglandin D2; Prostaglandins; Swine; Thromboxane B2 | 1995 |
Effects of dietary fibre on dimethylhydrazine-induced changes in prostanoid concentrations in rat colonic mucosa.
Topics: 1,2-Dimethylhydrazine; 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Carcinogens; Chromatography, High Pressure Liquid; Colon; Colonic Neoplasms; Dietary Fiber; Dimethylhydrazines; Dinoprostone; Galactans; Injections, Subcutaneous; Intestinal Mucosa; Male; Mannans; Plant Gums; Prostaglandin D2; Prostaglandins; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 1995 |
Transdermal modification of platelet function: an aspirin patch system results in marked suppression of platelet cyclooxygenase.
Topics: Administration, Cutaneous; Adult; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Skin; Thromboxane B2 | 1996 |
In vitro study of the anti-aggregating activity of two nitroderivatives of acetylsalicylic acid.
Topics: Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2; Thromboxane B2 | 1996 |
Magnesium inhibits human platelets.
Topics: Aspirin; Blood Platelets; Collagen; Female; Hirudins; Humans; In Vitro Techniques; Magnesium; Magnesium Sulfate; Male; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1996 |
Human whole blood assays for inhibition of prostaglandin G/H synthases-1 and -2 using A23187 and lipopolysaccharide stimulation of thromboxane B2 production.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcimycin; Cyclooxygenase Inhibitors; Escherichia coli; Female; Humans; In Vitro Techniques; Ionophores; Lipopolysaccharides; Male; Thromboxane B2 | 1996 |
Vascular thromboxane formation in hemostasis mechanism: correlation between bleeding time and vascular TXB2 in a patient with congenital platelet cyclo-oxygenase deficiency.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Adult; Arteries; Aspirin; Bleeding Time; Blood Platelets; Bone Marrow; Cyclooxygenase Inhibitors; Endothelium, Vascular; Epoprostenol; Female; Fibroblasts; Hemorrhagic Disorders; Humans; Isoenzymes; Monocytes; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Thromboxane B2; Uterus | 1996 |
More uses of known drugs.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Cyclooxygenase Inhibitors; Humans; Myocardial Infarction; Thromboxane B2 | 1995 |
Effect of aspirin treatment on plasma levels of keto PGF 1 alpha and thromboxane B2.
Topics: 6-Ketoprostaglandin F1 alpha; Arrhythmias, Cardiac; Aspirin; Case-Control Studies; Coronary Artery Bypass; Cyclooxygenase Inhibitors; Humans; Myocardial Infarction; Postoperative Care; Thromboxane B2; Time Factors | 1995 |
Effect of single and repeated doses of a new nitroderivative of acetylsalicylic acid on platelet TXA2 production in rats.
Topics: Animals; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Female; Nitrites; Rats; Rats, Sprague-Dawley; Thromboxane A2; Thromboxane B2 | 1996 |
Two mechanisms for platelet-mediated killing of tumour cells: one cyclo-oxygenase dependent and the other nitric oxide dependent.
Topics: Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Cytotoxicity, Immunologic; Hemoglobins; Humans; Indomethacin; Methylene Blue; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Tumor Cells, Cultured | 1996 |
Drug actions in preeclampsia: aspirin, but not magnesium chloride or dihydralazine, differentially inhibits cultured human trophoblast release of thromboxane and prostacyclin without affecting angiotensin II, endothelin-1, or leukotriene B4 secretion.
Topics: Angiotensin II; Antihypertensive Agents; Aspirin; Cells, Cultured; Cyclooxygenase Inhibitors; Dihydralazine; Endothelin-1; Epoprostenol; Female; Humans; Leukotriene B4; Magnesium Chloride; Pre-Eclampsia; Pregnancy; Thromboxane B2; Trophoblasts | 1997 |
Urinary leukotriene E4 and 11-dehydrothromboxane B2 in patients with aspirin-sensitive asthma.
Topics: Aspirin; Asthma; Case-Control Studies; Drug Hypersensitivity; Female; Humans; Leukotriene E4; Male; Middle Aged; Severity of Illness Index; Thromboxane B2 | 1997 |
Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Deferoxamine; Enzyme Activation; Fatty Acids, Unsaturated; Humans; Hydrazines; Hydrogen Peroxide; Leukotrienes; Lipid Peroxides; Oligopeptides; Peroxides; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; tert-Butylhydroperoxide; Thromboxane B2; Vitamin E | 1997 |
Experimental fat embolism induces urine 2,3-dinor-6-ketoprostaglandin F1alpha and 11-dehydrothromboxane B2 excretion in pigs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Cyclooxygenase Inhibitors; Embolism, Fat; Epoprostenol; Evaluation Studies as Topic; Hemodynamics; Hypertension, Pulmonary; Lung Diseases; Random Allocation; Swine; Thromboxane A2; Thromboxane B2 | 1997 |
Aspirin induces increased expression of both prostaglandin H synthase-1 and prostaglandin H synthase-2 in cultured human placental trophoblast.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cells, Cultured; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Humans; Hydroxyeicosatetraenoic Acids; Isomerism; Platelet Aggregation Inhibitors; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Synthesis Inhibitors; Radioimmunoassay; Thromboxane B2; Time Factors; Trophoblasts | 1997 |
Characteristics of protein kinase C-independent exocytosis in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Blood Platelets; Exocytosis; Humans; Indoles; Maleimides; Molecular Weight; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Thromboxane B2; Vasoconstrictor Agents | 1997 |
Cyclooxygenase inhibition decreases nitric oxide synthase activity in human platelets.
Topics: Aspirin; Blood Platelets; Blotting, Western; Calcium; Cyclic GMP; Cyclooxygenase Inhibitors; Cytosol; Humans; Indomethacin; Nitric Oxide Synthase; Osmolar Concentration; Thromboxane B2 | 1997 |
In vivo formation of 8-Epi-prostaglandin F2 alpha is increased in hypercholesterolemia.
Topics: Antioxidants; Aspirin; Cardiovascular Diseases; Cross-Sectional Studies; Cyclooxygenase Inhibitors; Dinoprost; Female; Humans; Hypercholesterolemia; Isoindoles; Lipid Peroxidation; Lipoproteins, LDL; Male; Middle Aged; Phenylbutyrates; Platelet Activation; Platelet Aggregation Inhibitors; Reactive Oxygen Species; Thromboxane B2; Vitamin E | 1997 |
Enhanced thromboxane biosynthesis in patients with chronic obstructive pulmonary disease. The Chronic Obstructive Bronchitis and Haemostasis Study Group.
Topics: Aged; Aspirin; Blood Platelets; Creatinine; Cyclooxygenase Inhibitors; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Oxygen Inhalation Therapy; Peptide Fragments; Platelet Activation; Prothrombin; Thromboxane B2; Thromboxanes | 1997 |
Immunosuppressive therapy for recurrent aborters with positive antiphospholipid antibodies and alteration of 6ketoPGF1 alpha/TXB2 ratio.
Topics: 6-Ketoprostaglandin F1 alpha; Abortion, Habitual; Adult; Antibodies, Antiphospholipid; Aspirin; Drugs, Chinese Herbal; Female; Humans; Immunosuppressive Agents; Prednisolone; Pregnancy; Thromboxane B2 | 1997 |
Effect of some cyclooxygenase inhibitors on the increase in guanosine 3':5'-cyclic monophosphate induced by NO-donors in human whole platelets.
Topics: Acetophenones; Aspirin; Blood Platelets; Cyclic GMP; Cyclooxygenase Inhibitors; Diclofenac; Humans; Indomethacin; Indoprofen; Nitric Oxide; Nitroprusside; Penicillamine; Phospholipases A; Thromboxane B2 | 1998 |
Aspirin-like molecules that covalently inactivate cyclooxygenase-2.
Topics: Acetylation; Acetylene; Alkynes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Cell Division; Cell Line; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Design; Humans; Indomethacin; Isoenzymes; Macrophages; Membrane Proteins; Mutagenesis, Site-Directed; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Sulfides; Thromboxane B2; Tumor Cells, Cultured | 1998 |
Further insights into the anti-aggregating activity of NMDA in human platelets.
Topics: Aspirin; Blood Platelets; Calcium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; In Vitro Techniques; Indomethacin; N-Methylaspartate; Nitric Oxide Synthase; omega-N-Methylarginine; Platelet Aggregation Inhibitors; Thromboxane B2 | 1998 |
Differing profiles of prostaglandin formation inhibition between selective prostaglandin H synthase-2 inhibitors and conventional NSAIDs in inflammatory and non-inflammatory sites of the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Gastric Juice; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitrobenzenes; Pleurisy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Sodium Chloride; Sulfonamides; Thromboxane B2 | 1998 |
Difference of (Ca2+)i movements in platelets stimulated by thrombin and TRAP: the involvement of alpha(IIb)beta3-mediated TXA2 synthesis.
Topics: Adenosine Diphosphate; Antibodies, Monoclonal; Apyrase; Aspirin; Blood Platelets; Calcium; Cyclooxygenase Inhibitors; Dipeptides; Fibrinogen; Humans; Ion Transport; Peptide Fragments; Phenylacetates; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Thrombin; Signal Transduction; Sulfonamides; Thrombin; Thromboxane A2; Thromboxane B2; Tirofiban; Tyrosine | 1998 |
Effective long-term inhibition of thromboxane production but not of serotonin release in patients with coronary heart disease by 30 mg/d acetylsalicylic acid dosage.
Topics: Aspirin; Blood Coagulation; Coronary Disease; Dose-Response Relationship, Drug; Humans; Myocardial Ischemia; Serotonin; Thromboxane A2; Thromboxane B2 | 1998 |
Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2alpha-III, an index of oxidant stress.
Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arachidonic Acids; Aspirin; Case-Control Studies; Creatinine; Cross-Sectional Studies; Cyclooxygenase Inhibitors; Dinoprost; Female; Follow-Up Studies; Free Radicals; Humans; Lipid Peroxidation; Lung Diseases, Obstructive; Male; Middle Aged; Oxidative Stress; Oxygen; Sex Factors; Smoking; Thromboxane B2; Time Factors | 1998 |
Effects of copper-aspirin complex on platelet aggregation and thrombosis in rabbits and mice.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Aspirin; Copper; Drug Combinations; Female; In Vitro Techniques; Intubation, Gastrointestinal; Male; Mice; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Radioimmunoassay; Random Allocation; Thrombosis; Thromboxane B2 | 1998 |
The effects of aspirin and hypothermia on platelet function in vivo.
Topics: Aspirin; Bleeding Time; Blood Platelets; Humans; Hyperthermia, Induced; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 1999 |
Effects of antiaggregant and antiinflammatory doses of aspirin on coronary hemodynamics and myocardial reactive hyperemia in conscious dogs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Bradykinin; Coronary Disease; Coronary Vessels; Cyclooxygenase Inhibitors; Diclofenac; Dogs; Dose-Response Relationship, Drug; Hyperemia; Male; Myocardium; Nitric Oxide Synthase; Nitroarginine; Salicylic Acid; Thromboxane B2; Time Factors | 1999 |
Inhibitory effects of copper-aspirin complex on platelet aggregation.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Female; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Serotonin; Thromboxane B2 | 1997 |
Thromboxane-dependent platelet activation in vivo precedes arterial thrombosis in thrombocythaemia: a rationale for the use of low-dose aspirin as an antithrombotic agent.
Topics: Adult; Aged; Aspirin; Erythromelalgia; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Activation; Platelet Aggregation Inhibitors; Thrombocytosis; Thromboxane B2 | 1999 |
Production of prostanoids and nitric oxide by infarcted heart in situ and the effect of aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Coronary Vessels; Enzyme Activation; Epoprostenol; Heart; Myocardial Infarction; Myocardium; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Prostaglandins; Rabbits; Thromboxane A2; Thromboxane B2 | 1999 |
Cyclosporine-induced coronary artery constriction--dissociation between thromboxane release and coronary vasospasm.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Cyclooxygenase Inhibitors; Cyclosporine; Endothelium, Vascular; Heart; Heart Rate; Immunosuppressive Agents; Male; Myocardial Contraction; Myocardium; Nifedipine; Nitric Oxide Donors; Nitroglycerin; Pharmaceutical Vehicles; Polyethylene Glycols; Prostanoic Acids; Rats; Rats, Wistar; Receptors, Thromboxane; Thromboxane B2; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Effects of dl-3-n-butylphthalide on production of TXB2 and 6-keto-PGF1 alpha in rat brain during focal cerebral ischemia and reperfusion.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Benzofurans; Brain; Ischemic Attack, Transient; Neuroprotective Agents; Rats; Reperfusion Injury; Thromboxane B2 | 1997 |
Ex vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Blood Pressure; Carcinoma; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Indans; Isoenzymes; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Salicylates; Substrate Specificity; Sulfonamides; Sulindac; Thromboxane B2; Tumor Cells, Cultured | 1999 |
Iron-dependent human platelet activation and hydroxyl radical formation: involvement of protein kinase C.
Topics: Adult; Aspirin; Blood Platelets; Catalase; Chelating Agents; Collagen; Deferoxamine; Deoxyribose; Diuretics, Osmotic; Dose-Response Relationship, Drug; Edetic Acid; Enzyme Inhibitors; Female; Humans; Hydroxyl Radical; Indoles; Iron; Isoquinolines; Male; Maleimides; Mannitol; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Sulfonamides; Thromboxane A2; Thromboxane B2 | 1999 |
Increased formation of thromboxane in vivo in humans with mastocytosis.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Aspirin; beta-Thromboglobulin; Cyclooxygenase Inhibitors; Female; Humans; Male; Methylhistamines; Middle Aged; Platelet Factor 4; Prostaglandins D; Thromboxane B2; Urticaria Pigmentosa | 1999 |
Superiority of platelet integrin GPIIb-IIIa receptor antagonist over aspirin in preventing cyclic flow reductions in the guinea pig middle cerebral artery.
Topics: Amides; Animals; Aspirin; Brain; Cerebral Arteries; Cerebrovascular Circulation; Fibrinolytic Agents; Guinea Pigs; Male; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Regional Blood Flow; Thromboxane B2 | 1999 |
Effects of sodium selenite on in vitro interactions between platelets and endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Aspirin; Blood Platelets; Cells, Cultured; Culture Media, Conditioned; Endothelium, Vascular; Enzyme Activation; Glutathione Peroxidase; Humans; Nitric Oxide; Platelet Aggregation; Selenium; Sodium Selenite; Thromboxane A2; Thromboxane B2 | 1999 |
Plasma thromboxane and prostacyclin are linear related and increased in patients presenting with acute myocardial infarction.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aspirin; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Myocardial Infarction; Reference Values; Thromboxane B2 | 1999 |
Induction of cytosolic phospholipase A2 and prostaglandin H2 synthase-2 by lipopolysaccharide in human polymorphonuclear leukocytes.
Topics: Aspirin; Calcimycin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Induction; Group IV Phospholipases A2; Humans; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Neutrophils; Nitrobenzenes; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Thromboxane B2; Thromboxane-A Synthase | 1999 |
Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4).
Topics: Animals; Aspirin; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Activation; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Ibuprofen; Indomethacin; Isoenzymes; Lipoxins; Liver; Male; Membrane Proteins; Phenobarbital; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Thromboxane B2 | 1999 |
Monitoring of the thromboxane A2/prostacyclin ratio in the urine of patients with retinal vascular occlusion through the low-dose-aspirin therapy using the gas chromatography/selected ion monitoring method.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aspirin; Dose-Response Relationship, Drug; Epoprostenol; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Pilot Projects; Prostaglandins F; Retinal Artery Occlusion; Retinal Vein Occlusion; Thromboxane A2; Thromboxane B2; Thromboxanes | 1999 |
[The effect of monotherapy with ciprofibrate and in combination with acetylsalicylic acid on the spectrum of lipids, thromboxane and fibrinogen in patients with atherosclerosis and hyperlipoproteinemia].
Topics: Aged; Arteriosclerosis; Aspirin; Clofibric Acid; Drug Therapy, Combination; Female; Fibric Acids; Fibrinogen; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Lipids; Male; Middle Aged; Platelet Aggregation Inhibitors; Thromboxane B2 | 1999 |
Renal glomerular response to the inhibition of prostaglandin E2 synthesis and protein loading after the relief of unilateral ureteropelvic junction obstruction.
Topics: Adolescent; Aspirin; Child; Dinoprostone; Endothelins; Female; Glomerular Filtration Rate; Humans; Kidney Pelvis; Male; Postoperative Care; Thromboxane B2; Ureteral Obstruction | 2000 |
Ulinastatin, an elastase inhibitor, inhibits the increased mRNA expression of prostaglandin H2 synthase-type 2 in Kawasaki disease.
Topics: Aspirin; Child; Child, Preschool; Female; Glycoproteins; Humans; Isoenzymes; Lipopolysaccharides; Male; Mucocutaneous Lymph Node Syndrome; Neutrophils; Pancreatic Elastase; Phospholipases A; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Thromboxane B2; Thromboxane-A Synthase | 2000 |
The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice: evidence that eicosanoids other than thromboxane contribute to atherosclerosis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Aspirin; Body Weight; Cell Adhesion; Cholesterol; Endothelium, Vascular; Female; Humans; Intercellular Adhesion Molecule-1; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Naphthalenes; Platelet Aggregation Inhibitors; Propionates; Receptors, Thromboxane; Tetrahydronaphthalenes; Thromboxane A2; Thromboxane B2; U937 Cells; Umbilical Veins; Vasoconstrictor Agents | 2000 |
Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis.
Topics: Age Factors; Animals; Aorta; Arteriosclerosis; Aspirin; Diet, Atherogenic; Disease Models, Animal; Eicosanoids; Epoprostenol; Female; Hominidae; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins F; Receptors, LDL; Thromboxane A2; Thromboxane B2 | 2000 |
Tramadol anti-inflammatory activity is not related to a direct inhibitory action on prostaglandin endoperoxide synthases.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; In Vitro Techniques; Isoenzymes; Membrane Proteins; Monocytes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Thromboxane B2; Tramadol | 2000 |
Assay of cyclooxygenase-1 and 2 in human monocytes.
Topics: Aspirin; Blotting, Western; Cell Separation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Eicosanoids; Humans; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Monocytes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Thromboxane B2 | 2000 |
Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Apoptosis; Arachidonic Acid; Aspirin; Biomarkers; Cardiomyopathies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Doxorubicin; Enzyme Induction; Epoprostenol; Heart; Iloprost; Isoenzymes; L-Lactate Dehydrogenase; Male; Membrane Proteins; Myocardium; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sulfonamides; Thromboxane B2; Transcription Factors; Troponin T | 2001 |
Thromboxane synthase regulates the migratory phenotype of human glioma cells.
Topics: Arachidonic Acids; Aspirin; Astrocytes; Benzofurans; Brain Neoplasms; Cell Adhesion; Cell Movement; Enzyme Induction; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; GTP-Binding Proteins; Humans; Imidazoles; Indomethacin; Lysine; Models, Biological; Neoplasm Proteins; Neoplastic Stem Cells; Oligodendroglia; Pentanoic Acids; Phenotype; Pyridines; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Thromboxane B2; Thromboxane-A Synthase; Tumor Cells, Cultured | 1999 |
NCX4016 (NO-Aspirin) has multiple inhibitory effects in LPS-stimulated human monocytes.
Topics: Aspirin; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrinolytic Agents; Guanylate Cyclase; Humans; Interleukin-6; Lipopolysaccharides; Monocytes; Nitric Oxide; Oxadiazoles; Quinoxalines; Thromboplastin; Thromboxane B2; Tumor Necrosis Factor-alpha | 2001 |
Possible involvement of mast-cell activation in aspirin provocation of aspirin-induced asthma.
Topics: Adult; Aged; Aspirin; Asthma; Bronchial Provocation Tests; Cyclooxygenase Inhibitors; Dinoprost; Female; Forced Expiratory Volume; Humans; Leukotriene E4; Male; Mast Cells; Methylhistamines; Middle Aged; Sensitivity and Specificity; Thromboxane A2; Thromboxane B2; Time Factors | 2001 |
Anti-platelet and anti-thrombotic effects of triacetylshikimic acid in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Abdominal; Aspirin; Blood Platelets; Cyclic AMP; Cyclic GMP; Male; Partial Thromboplastin Time; Platelet Aggregation Inhibitors; Prothrombin Time; Radioimmunoassay; Rats; Rats, Wistar; Shikimic Acid; Thrombin Time; Thrombosis; Thromboxane B2 | 2002 |
Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients.
Topics: Adult; Anti-Asthmatic Agents; Aspirin; Asthma; Blood Proteins; Bronchial Provocation Tests; Chromones; Drug Hypersensitivity; Eosinophil Granule Proteins; Eosinophils; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Leukotriene D4; Leukotriene E4; Male; Middle Aged; Ribonucleases; Thromboxane B2 | 2002 |
Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Biphenyl Compounds; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Cells, Cultured; Enzyme Inhibitors; Fatty Acids, Unsaturated; Heptanoic Acids; Humans; Hydrazines; Imidazoles; Inositol Phosphates; Kidney; Methacrylates; Phenylacetates; Platelet Activating Factor; Platelet Activation; Prostaglandin H2; Prostaglandins H; Protein Isoforms; Receptors, Thromboxane; Recombinant Fusion Proteins; Sulfonamides; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 2002 |
Nitric oxide, anti-inflammatory drugs on renal prostaglandins and cyclooxygenase-2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Isoenzymes; Kidney; Male; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostaglandins F; Pyrazoles; Rabbits; Salicylates; Sulfonamides; Thromboxane B2 | 2002 |
Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Canada; Cardiovascular Diseases; Case-Control Studies; Cohort Studies; Comorbidity; Cyclooxygenase Inhibitors; Death, Sudden, Cardiac; Demography; Female; Follow-Up Studies; Humans; Male; Myocardial Infarction; Odds Ratio; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Secondary Prevention; Stroke; Thromboxane B2; Thromboxanes; Vitamin E | 2002 |
NCX4016 (NO-aspirin) reduces infarct size and suppresses arrhythmias following myocardial ischaemia/reperfusion in pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Aspirin; Coronary Disease; Endothelium, Vascular; Hemodynamics; Leukocytes; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Platelet Aggregation; Swine; Thromboxane B2; Ventricular Fibrillation | 2002 |
Association between ibuprofen, aspirin therapy found.
Topics: Aspirin; Drug Interactions; Humans; Ibuprofen; Platelet Aggregation; Thromboxane B2 | 2002 |
In vivo effects of meloxicam and aspirin on blood, gastric mucosal, and synovial fluid prostanoid synthesis in dogs.
Topics: Animals; Aspirin; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dinoprostone; Dog Diseases; Dogs; Gastric Mucosa; Isoenzymes; Male; Meloxicam; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Stifle; Synovial Fluid; Thiazines; Thiazoles; Thromboxane B2 | 2002 |
Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Benzene Derivatives; Calcimycin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Furans; Humans; Indomethacin; Ionophores; Isoenzymes; Leukotrienes; Lipopolysaccharides; Lipoxygenase; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Thromboxane B2 | 2002 |
Effects of the selective inhibition of platelet thromboxane synthesis on the platelet-subendothelium interaction.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Animals; Aspirin; Blood Platelets; Chlorobenzenes; Cyclooxygenase Inhibitors; Dinoprost; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Imidazoles; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; Rabbits; Receptors, Thromboxane; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 2002 |
Circulation and hemostatic function of autologous fresh, liquid-preserved, and cryopreserved baboon platelets transfused to correct an aspirin-induced thrombocytopathy.
Topics: Animals; Aspirin; Bleeding Time; Blood Platelets; Blood Preservation; Blood Transfusion, Autologous; Cell Survival; Citric Acid; Cryopreservation; Glucose; Hemorrhagic Disorders; Hemostasis; Male; Papio; Platelet Count; Platelet Transfusion; Solutions; Species Specificity; Temperature; Thromboxane B2; Time Factors | 2002 |
Induction of thromboxane A2 synthesizing enzymes in DMSO-induced granulocytic differentiation of HL-60 cells.
Topics: Aspirin; Cell Differentiation; Cyclooxygenase 1; Cyclooxygenase 2; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Induction; HL-60 Cells; Humans; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Time Factors | 2002 |
NCX-4016 (NO-aspirin) inhibits lipopolysaccharide-induced tissue factor expression in vivo: role of nitric oxide.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cyclooxygenase 2; Cysteine Proteinase Inhibitors; Drug Administration Schedule; Flow Cytometry; Gastric Mucosa; Interleukin-1; Isoenzymes; Isosorbide Dinitrate; Male; Monocytes; Nitric Oxide; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thromboplastin; Thromboxane B2; Tumor Necrosis Factor-alpha | 2002 |
Aspirin resistance.
Topics: Aspirin; Biomarkers; Cyclooxygenase Inhibitors; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Risk; Thrombosis; Thromboxane B2; Thromboxanes | 2002 |
Genetic variation in cyclooxygenase 1: effects on response to aspirin.
Topics: Adult; Alanine; Aspirin; Blood Platelets; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Cysteine; Dinoprost; DNA, Complementary; Ethanol; Female; Glycine; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Polymorphism, Genetic; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Reference Values; Sequence Analysis, DNA; Sex Characteristics; Threonine; Thromboxane B2 | 2003 |
Synergistic effect of D-003 and aspirin on experimental thrombosis models.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Aspirin; Death, Sudden; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fatty Acids; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thrombosis; Thromboxane B2 | 2003 |
Single dose of acetylsalicylic acid prevents thromboxane release after tourniquet ischemia.
Topics: Adult; Aspirin; Humans; Ischemia; Thromboxane B2; Tourniquets | 2003 |
Aspirin alters arterial function in patients with chronic heart failure treated with ACE inhibitors: a dose-mediated deleterious effect.
Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Arteries; Aspirin; Blood Pressure; Chronic Disease; Controlled Clinical Trials as Topic; Cyclooxygenase Inhibitors; Diastole; Dose-Response Relationship, Drug; Enalapril; Endpoint Determination; Female; Heart Failure; Heart Rate; Humans; Lisinopril; Male; Manometry; Middle Aged; Observer Variation; Prospective Studies; Ramipril; Renin; Reproducibility of Results; Single-Blind Method; Systole; Thromboxane B2; Time Factors; Treatment Outcome | 2003 |
Effects of camonagrel, a selective inhibitor of platelet thromboxane synthase, on the platelet-subendothelium interaction.
Topics: Adolescent; Adult; Animals; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Humans; Imidazoles; Indans; Male; Middle Aged; Platelet Aggregation; Prostaglandins; Prostaglandins E; Rabbits; Thrombosis; Thromboxane B2; Thromboxane-A Synthase; Tunica Intima | 2003 |
[Effect of aspirin combined with perindopril on prostacyclin, thromboxone A2, and norepinephrine in the blood of arteriosclerosis rabbit models and the cardiac function].
Topics: Animals; Arteriosclerosis; Aspirin; Drug Synergism; Epoprostenol; Female; Heart Function Tests; Heart Rate; Male; Norepinephrine; Perindopril; Rabbits; Random Allocation; Thromboxane A2; Thromboxane B2 | 2003 |
Nitric oxide-releasing aspirin inhibits vasoconstriction in perfused tail artery of normotensive and spontaneously hypertensive rats.
Topics: Animals; Arteries; Aspirin; Blood Pressure; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Nitrates; Nitric Oxide Donors; Nitrites; Perfusion; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tail; Thromboxane B2; Time Factors; Vasoconstriction | 2003 |
In vitro effects of clopidogrel on the platelet-subendothelium interaction, platelet thromboxane and endothelial prostacyclin production, and nitric oxide synthesis.
Topics: Adult; Aspirin; Blood Platelets; Cells, Cultured; Clopidogrel; Epoprostenol; Humans; Male; Middle Aged; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Ticlopidine | 2004 |
Lack of aspirin effect: aspirin resistance or resistance to taking aspirin?
Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Cohort Studies; Disease-Free Survival; Drug Resistance; Follow-Up Studies; Humans; Outcome Assessment, Health Care; Patient Compliance; Platelet Aggregation Inhibitors; Risk Factors; Thromboxane B2; Treatment Refusal | 2004 |
Cyclooxygenase inhibition is associated with downregulation of apolipoprotein AI promoter activity in cultured hepatoma cell line HepG2.
Topics: Apolipoprotein A-I; Arachidonic Acid; Aspirin; Blotting, Northern; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Down-Regulation; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Isoenzymes; Liver Neoplasms; Membrane Proteins; Plasmids; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Prostaglandins; RNA, Messenger; Thromboxane B2; Transcription, Genetic | 2004 |
Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation.
Topics: Acetates; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Epinephrine; Humans; In Vitro Techniques; Isoenzymes; Lipoxygenase Inhibitors; Membrane Proteins; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyrroles; Quinolines; Thrombin; Thromboxane B2 | 2004 |
Aspirin resistance and diabetic angiopathy: back to the future.
Topics: Aspirin; Blood Platelets; Diabetic Angiopathies; Drug Resistance; Humans; Platelet Aggregation; Thromboxane B2 | 2004 |
Thrombosis and neointima formation in vein grafts are inhibited by locally applied aspirin through endothelial protection.
Topics: Animals; Arteriosclerosis; Aspirin; Blood Vessel Prosthesis Implantation; Carotid Arteries; Disease Models, Animal; Endothelium, Vascular; Fibrinolytic Agents; Graft Occlusion, Vascular; Hyperplasia; Mice; Mice, Knockout; Mice, Transgenic; Platelet Aggregation Inhibitors; Postoperative Complications; Receptor, TIE-2; Thrombosis; Thromboxane B2; Tunica Intima; Venae Cavae | 2004 |
Biological assessment of aspirin efficacy on healthy individuals: heterogeneous response or aspirin failure?
Topics: Absorption; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Creatinine; Cyclooxygenase 2; Factor XIII; Female; Genetic Variation; Genotype; Humans; Integrin alpha2beta1; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Risk Factors; Thromboxane B2; Time Factors | 2005 |
Thromboxane and prostacyclin biosynthesis in patients with acute spontaneous intracerebral hemorrhage.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Aged; Aspirin; Bleeding Time; Blood Coagulation; Cerebral Hemorrhage; Epoprostenol; Female; Humans; Male; Middle Aged; Prospective Studies; Regression Analysis; Thromboxane A2; Thromboxane B2 | 2005 |
Streptococcus sanguis-induced platelet activation involves two waves of tyrosine phosphorylation mediated by FcgammaRIIA and alphaIIbbeta3.
Topics: Adaptor Proteins, Signal Transducing; Antigens, CD; Aspirin; Blood Platelets; Cross-Linking Reagents; Enzyme Precursors; Humans; Immunoglobulin G; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Phosphatidic Acids; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Endothelial Cell Adhesion Molecule-1; Platelet Glycoprotein GPIIb-IIIa Complex; Protein-Tyrosine Kinases; Receptors, IgG; Serotonin; Signal Transduction; Streptococcus sanguis; Syk Kinase; Thromboxane B2; Type C Phospholipases; Tyrosine | 2005 |
Cyclooxygenase inhibition with acetylsalicylic acid unmasks a role for prostacyclin in erythropoietin-induced hypertension in uremic rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Thoracic; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelin-1; Epoprostenol; Erythropoietin; Humans; Hypertension; Kidney Cortex; Kidney Function Tests; Male; Mesenteric Arteries; Rats; Rats, Wistar; Recombinant Proteins; Thromboxane B2; Uremia | 2005 |
Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016).
Topics: Animals; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dialysis; Dinoprostone; Dose-Response Relationship, Drug; Hemostatics; Humans; Kinetics; Molecular Structure; Monocytes; Platelet Aggregation Inhibitors; Sheep; Spectrophotometry; Thrombin; Thromboxane B2; Time Factors | 2005 |
Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular disease.
Topics: Aged; Aspirin; Blood Platelets; Cardiovascular Diseases; Female; Humans; Middle Aged; Tablets, Enteric-Coated; Thromboxane B2 | 2005 |
2-(2-Br-phenyl)-8-methoxy-benzoxazinone (HPW-RX2), a direct thrombin inhibitor with a suppressive effect on thromboxane formation in platelets.
Topics: Adenosine Triphosphate; Arachidonic Acid; Aspirin; Benzoxazines; Blood Platelets; Calcium; Calcium Signaling; Collagen; Dose-Response Relationship, Drug; Humans; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin D2; Receptors, Thrombin; Thrombin; Thromboxane A2; Thromboxane B2 | 2005 |
Stabilization of advanced atherosclerosis in low-density lipoprotein receptor-deficient mice by aspirin.
Topics: Animals; Aorta, Thoracic; Aspirin; Atherosclerosis; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Immunohistochemistry; Male; Mice; Receptors, LDL; Thromboxane B2; Treatment Outcome | 2006 |
Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Coronary Artery Disease; Cyclooxygenase 1; Diabetes Mellitus; Female; Genotype; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Membrane Glycoproteins; Polymorphism, Single Nucleotide; Sex Factors; Thromboxane B2 | 2006 |
Dose- and time-dependent antiplatelet effects of aspirin.
Topics: Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cross-Over Studies; Dose-Response Relationship, Drug; Epoprostenol; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Thromboxanes; Time Factors | 2006 |
Reduced blood platelet sensitivity to aspirin in coronary artery disease: are dyslipidaemia and inflammatory states possible factors predisposing to sub-optimal platelet response to aspirin?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; C-Reactive Protein; Cholesterol; Coronary Artery Disease; Cross-Sectional Studies; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Inflammation; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Triglycerides | 2006 |
Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism.
Topics: Antigens, Neoplasm; Aspirin; Blood Platelets; Coronary Artery Disease; Cyclooxygenase 1; Dinoprost; Drug Resistance; Humans; Integrin beta3; Lipid Peroxidation; Nephelometry and Turbidimetry; Oxidative Stress; Platelet Aggregation; Polymorphism, Genetic; Polymorphism, Single Nucleotide; RNA, Messenger; Thromboxane A2; Thromboxane B2 | 2006 |
Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Clopidogrel; Coronary Artery Disease; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Resistance; Female; Flow Cytometry; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Signal Transduction; Thrombosis; Thromboxane B2; Ticlopidine; Time Factors; Treatment Refusal | 2006 |
Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Coronary Artery Disease; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Thromboxane B2; Whole Blood Coagulation Time | 2006 |
Moderation of the platelet releasate response by aspirin.
Topics: Aspirin; Blood Platelets; Collagen; Cytokines; Gene Expression Regulation; Humans; Immunoenzyme Techniques; Inflammation; Mass Spectrometry; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombospondins; Thromboxane B2; Time Factors | 2007 |
Drug insight: aspirin resistance-fact or fashion?
Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2007 |
Determination of aspirin responsiveness by use of whole blood platelet aggregometry.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Blood Donors; Clopidogrel; Collagen; Coronary Artery Disease; Drug Resistance; Electric Impedance; Female; Humans; In Vitro Techniques; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; Reference Values; Sex Factors; Thromboxane B2; Ticlopidine | 2007 |
Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1.
Topics: Adult; Arachidonic Acid; Aspirin; beta-Thromboglobulin; Black or African American; Blood Platelets; Cardiovascular Diseases; Coronary Disease; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Resistance; Dyslipidemias; Female; Genetic Heterogeneity; Genetic Predisposition to Disease; Genetic Variation; Humans; Hyperglycemia; Hypertension; Male; Membrane Proteins; Middle Aged; Phenotype; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Sex Characteristics; Smoking; Thrombophilia; Thrombosis; Thromboxane B2; White People | 2007 |
Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study.
Topics: Aspirin; Atherosclerosis; Biomarkers; Black or African American; Case-Control Studies; Coronary Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Longitudinal Studies; Male; Middle Aged; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Stroke; Thromboxane B2; United States; White People | 2008 |
Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits.
Topics: Adenosine Diphosphate; Analysis of Variance; Animals; Aspirin; Biomarkers; Bleeding Time; Blood Platelets; Carotid Artery Thrombosis; Carotid Artery, Common; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Hemostasis; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Protein Binding; Rabbits; Receptors, Purinergic P2; Regional Blood Flow; Thromboxane B2; Ticlopidine | 2007 |
Gallic acid, a dietary polyphenolic component, blunts the inhibition of platelet COX-1 by aspirin: preliminary in-vitro findings.
Topics: Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Food-Drug Interactions; Gallic Acid; Humans; In Vitro Techniques; Platelet Aggregation; Salicylic Acid; Thromboxane B2 | 2007 |
Screening for aspirin resistance in stable coronary artery patients by three different tests.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Bleeding Time; Blood Platelets; Coronary Artery Disease; Drug Evaluation, Preclinical; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboembolism; Thromboxane B2 | 2007 |
Differences in the influence of the interaction between acetylsalicylic acid and salicylic acid on platelet function in whole blood and isolated platelets: influence of neutrophils.
Topics: Adult; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Drug Interactions; Humans; In Vitro Techniques; Male; Neutrophils; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Salicylic Acid; Thromboxane B2 | 2007 |
French maritime pine bark extract Pycnogenol reduces thromboxane generation in blood from diabetic male rats.
Topics: Animals; Aspirin; Blood Glucose; Body Weight; C-Peptide; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Flavonoids; Male; Plant Extracts; Rats; Rats, Wistar; Thromboxane B2; Thromboxanes | 2008 |
Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Portal; Lasers; Leukotriene B4; Male; Nitrobenzenes; Platelet Activation; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Thrombosis; Thromboxane B2 | 2007 |
Aspirin resistance in children with heart disease at risk for thromboembolism: prevalence and possible mechanisms.
Topics: Adolescent; Aspirin; Blood Platelets; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Resistance; Female; Follow-Up Studies; Heart Defects, Congenital; Humans; Infant; Male; Platelet Aggregation Inhibitors; Prevalence; Prognosis; Retrospective Studies; Risk Factors; Texas; Thromboembolism; Thromboxane B2 | 2008 |
Predominant basal directional release of thromboxane, but not prostacyclin, by placental trophoblasts from normal and preeclamptic pregnancies.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arachidonic Acid; Aspirin; Epoprostenol; Female; Humans; Placenta; Pre-Eclampsia; Pregnancy; Receptors, Thromboxane; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes; Trophoblasts; Vasoconstriction | 2008 |
AspirinWorks: a new immunologic diagnostic test for monitoring aspirin effect.
Topics: Aspirin; Cyclooxygenase Inhibitors; Humans; Immunoassay; Reproducibility of Results; Thromboxane B2 | 2008 |
Circulating endothelial progenitor cells and residual in vivo thromboxane biosynthesis in low-dose aspirin-treated polycythemia vera patients.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Aspirin; Blood; Case-Control Studies; Colony-Forming Units Assay; Endothelial Cells; Female; Humans; Male; Middle Aged; Polycythemia Vera; Stem Cells; Thromboxane A2; Thromboxane B2; Thromboxanes | 2008 |
Targeting the urine and plasma determinants of thromboxane A2 metabolism in detection of aspirin effectiveness.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Resistance; Male; Models, Biological; Rats; Rats, Wistar; Thromboxane A2; Thromboxane B2 | 2008 |
Assessment of aspirin resistance varies on a temporal basis in patients with ischaemic heart disease.
Topics: Aspirin; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2009 |
Virgin olive oil polyphenol hydroxytyrosol acetate inhibits in vitro platelet aggregation in human whole blood: comparison with hydroxytyrosol and acetylsalicylic acid.
Topics: 6-Ketoprostaglandin F1 alpha; Acetates; Adult; Aspirin; Blood Platelets; Catechols; Dose-Response Relationship, Drug; Female; Humans; Leukocytes; Male; Nitric Oxide; Olive Oil; Phenylethyl Alcohol; Plant Oils; Platelet Aggregation; Thromboxane B2 | 2009 |
Pharmacokinetic and pharmacodynamic study of NO-donating aspirin in F344 rats.
Topics: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colon; Drug Evaluation, Preclinical; Eicosanoids; Male; Nitric Oxide; Rats; Rats, Inbred F344; Salicylic Acid; Thromboxane B2; Time Factors | 2008 |
Biochemical evaluation of the antiplatelet effect of aspirin in patients at different levels of cardiovascular risk.
Topics: Aged; Aspirin; Cardiovascular Diseases; Diabetes Mellitus; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk; Thromboxane B2 | 2008 |
Comparison of pharmacokinetic and pharmacodynamic profiles of aspirin following oral gavage and diet dosing in rats.
Topics: Administration, Oral; Animals; Aspirin; Colon; Diet; Dinoprostone; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred F344; Salicylates; Thromboxane B2; Time Factors | 2009 |
Effect of low-dose aspirin for skin rash associated with erlotinib therapy in patients with lung cancer.
Topics: Aged; Aspirin; Dose-Response Relationship, Drug; Erlotinib Hydrochloride; Exanthema; Female; Humans; Lung Neoplasms; Male; Platelet Activation; Platelet Aggregation Inhibitors; Protein Kinase Inhibitors; Quinazolines; Thromboxane B2; Treatment Outcome | 2009 |
Aspirin resistance transient laboratory finding or important clinical entity?
Topics: Adult; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Drug Resistance; Humans; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 2009 |
Response variability to aspirin and one-year prediction of vascular events in patients with stable coronary artery disease.
Topics: Aged; Aspirin; Blood Platelets; Coronary Artery Disease; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Thromboxane B2 | 2010 |
Letter by cattaneo regarding article, "incomplete inhibition of thromboxane biosynthesis by acetylsalicylic Acid: determinants and effect on cardiovascular risk".
Topics: Aged; Aspirin; Cardiovascular Diseases; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Follow-Up Studies; Humans; Internationality; Male; Middle Aged; Risk Factors; Survival Rate; Thromboxane B2; Thromboxanes | 2009 |
Response to aspirin in healthy individuals. Cross-comparison of light transmission aggregometry, VerifyNow system, platelet count drop, thromboelastography (TEG) and urinary 11-dehydrothromboxane B(2).
Topics: Adult; Aspirin; Blood Platelets; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; ROC Curve; Sensitivity and Specificity; Thrombelastography; Thromboxane B2; Young Adult | 2009 |
Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study).
Topics: Adult; Aspirin; Cohort Studies; Drug Resistance; Female; Humans; Male; Middle Aged; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Prevalence; Sex Factors; Thromboxane B2 | 2009 |
Platelet monitoring for PCI: which test is the one to choose?
Topics: Acute Coronary Syndrome; Aspirin; Blood Platelets; Clopidogrel; Electric Impedance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Thromboxane B2; Ticlopidine | 2009 |
The antiplatelet effect of aspirin is reduced by proton pump inhibitors in patients with coronary artery disease.
Topics: Aged; Aspirin; Biomarkers; Case-Control Studies; Coronary Artery Disease; Drug Interactions; Female; Humans; Male; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Registries; Thromboxane B2 | 2010 |
Post interventional cardiology urinary thromboxane correlates with PlateletMapping detected aspirin resistance.
Topics: Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Arachidonic Acid; Aspirin; Blood Platelets; Cardiology; Humans; Platelet Activation; Platelet Count; Thromboxane B2 | 2010 |
Association of cyclooxygenase-1-dependent and -independent platelet function assays with adverse clinical outcomes in aspirin-treated patients presenting for cardiac catheterization.
Topics: Adult; Aspirin; Blood Platelets; Cardiac Catheterization; Collagen; Coronary Artery Disease; Cyclooxygenase 1; Drug Resistance; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; P-Selectin; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Thromboxane B2; Treatment Outcome | 2009 |
Aspirin inhibits fractalkine expression in atherosclerotic plaques and reduces atherosclerosis in ApoE gene knockout mice.
Topics: Animals; Aorta; Apolipoproteins E; Aspirin; Atherosclerosis; C-Reactive Protein; Chemokine CX3CL1; Cholesterol; Cyclooxygenase 1; Cyclooxygenase 2; Dietary Fats; Gene Expression; Male; Membrane Proteins; Mice; Mice, Knockout; Prostaglandins F; Thromboxane B2; Triglycerides | 2010 |
Platelet function recovery after cessation of aspirin: preliminary study of volunteers and surgical patients.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Coagulation; Blood Platelets; Case-Control Studies; Drug Administration Schedule; Elective Surgical Procedures; Epinephrine; Female; Humans; International Normalized Ratio; Longitudinal Studies; Male; Middle Aged; Partial Thromboplastin Time; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Recovery of Function; Thromboxane B2; Time Factors; Young Adult | 2010 |
Serum thromboxane B2 compared to five other platelet function tests for the evaluation of aspirin effect in stable cardiovascular disease.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Pressure; Cardiovascular Diseases; Case-Control Studies; Clopidogrel; Female; Fish Oils; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Statistics as Topic; Statistics, Nonparametric; Surveys and Questionnaires; Thromboxane B2; Ticlopidine | 2010 |
Inhibition of platelet function by low dose acetylsalicylic acid in patients with cerebrovascular disease.
Topics: Aged; Aged, 80 and over; Aspirin; Bleeding Time; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 1983 |
Laboratory evaluation of aspirin responsiveness.
Topics: Aspirin; Humans; Platelet Aggregation; Platelet Function Tests; Thromboxane B2 | 2010 |
Virgin olive oil administration improves the effect of aspirin on retinal vascular pattern in experimental diabetes mellitus.
Topics: Animals; Aorta; Aspirin; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Horseradish Peroxidase; Male; Nitric Oxide; Olea; Olive Oil; Permeability; Plant Oils; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Retinal Vessels; Thromboxane B2 | 2010 |
The inhibitory effect of statins on urinary 11-dehydrothromboxane levels.
Topics: Aged; Aspirin; Atorvastatin; Biomarkers; Blood Glucose; Blood Platelets; C-Reactive Protein; Cholesterol, HDL; Cholesterol, LDL; Czech Republic; Down-Regulation; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; Platelet Aggregation Inhibitors; Pyrroles; Simvastatin; Thromboxane B2; Time Factors; Treatment Outcome; Triglycerides | 2010 |
Platelet activation patterns in platelet size sub-populations: differential responses to aspirin in vitro.
Topics: Acid Phosphatase; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Cell Size; Cells, Cultured; Fibrinogen; Humans; Isoenzymes; P-Selectin; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Tartrate-Resistant Acid Phosphatase; Thromboxane B2; von Willebrand Factor | 2010 |
Aspirin resistance following pediatric cardiac surgery.
Topics: Administration, Oral; Administration, Rectal; Aspirin; Biomarkers; C-Reactive Protein; Cardiac Surgical Procedures; Drug Resistance; Fibrinolytic Agents; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Inflammation Mediators; Logistic Models; New York; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Assessment; Risk Factors; Suppositories; Thrombosis; Thromboxane B2; Time Factors; Treatment Outcome; Up-Regulation | 2010 |
Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes.
Topics: Acetaminophen; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Cell Line, Tumor; Cyclooxygenase Inhibitors; Dinoprostone; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen Peroxide; Mice; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Salicylic Acid; Thromboxane B2 | 2010 |
Clinical determinants of aspirin resistance in diabetes.
Topics: Albuminuria; Aspirin; Cohort Studies; Diabetic Angiopathies; Drug Resistance; Female; Glycated Hemoglobin; Humans; Insulin Resistance; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Waist Circumference | 2010 |
Patients with previous definite stent thrombosis have a reduced antiplatelet effect of aspirin and a larger fraction of immature platelets.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Blood Platelets; Case-Control Studies; Chi-Square Distribution; Coronary Artery Disease; Denmark; Drug Resistance; Female; Flow Cytometry; Humans; Linear Models; Male; Medication Adherence; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Retrospective Studies; Stents; Thrombosis; Thromboxane B2; Time Factors; Treatment Outcome | 2010 |
Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Biomarkers; Blood Platelets; Case-Control Studies; Chi-Square Distribution; Collagen; Coronary Artery Disease; Denmark; Diabetes Mellitus, Type 2; Female; Humans; Linear Models; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Registries; Risk Assessment; Risk Factors; Smoking; Thrombopoietin; Thromboxane B2 | 2011 |
Anti-inflammatory effects of chronic aspirin on brain arachidonic acid metabolites.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Brain; Dinoprostone; Humans; Leukotriene B4; Lipopolysaccharides; Lipoxins; Male; Rats; Rats, Inbred F344; Thromboxane B2 | 2011 |
Differences in the in vitro antiplatelet effect of dexibuprofen, ibuprofen, and flurbiprofen in human blood.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Dinoprostone; Dose-Response Relationship, Drug; Female; Flurbiprofen; Humans; Ibuprofen; Leukocytes; Male; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2010 |
Inconsistency of different methods for assessing ex vivo platelet function: relevance for the detection of aspirin resistance.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane B2; Young Adult | 2010 |
Comparison of methods to evaluate aspirin-mediated platelet inhibition after percutaneous intervention with stent implantation.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cardiovascular Diseases; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thromboxane B2; Treatment Outcome | 2011 |
1-Phenyl-6,7-dihydroxy-isochroman suppresses lipopolysaccharide-induced pro-inflammatory mediator production in human monocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Chromans; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Inflammation; Lipopolysaccharides; Monocytes; NF-kappa B; Olive Oil; Plant Oils; Thromboxane B2 | 2011 |
BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apolipoproteins E; Aspirin; Atherosclerosis; Dinoprost; Drug Therapy, Combination; Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Mice; Mice, Knockout; Receptors, Thromboxane; Saphenous Vein; Sulfonylurea Compounds; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Vascular Cell Adhesion Molecule-1 | 2011 |
Influence of nonsteroidal anti-inflammatory drugs on the antiplatelet effects of aspirin in rats.
Topics: Acetylation; Adenosine Diphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Collagen; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Drug Interactions; Etodolac; Ibuprofen; Male; Phenylpropionates; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 2011 |
Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients.
Topics: Adolescent; Adult; Aged; Alleles; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma, Aspirin-Induced; Female; Forced Expiratory Volume; Gene Frequency; Genetic Diseases, Inborn; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Thromboxane B2; Thromboxane-A Synthase; Young Adult | 2011 |
Urinary 11-dehydro thromboxane B₂ levels in type 2 diabetic patients before and during aspirin intake.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Diabetes Mellitus, Type 2; Humans; Male; Middle Aged; Thromboxane B2 | 2011 |
Aspirin failure in patients presenting with acute cerebrovascular ischaemia.
Topics: Acute Disease; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Brain Ischemia; Drug Resistance; Female; Humans; Male; P-Selectin; Patient Compliance; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane B2 | 2011 |
Aspirin resistance in off-pump coronary artery bypass grafting.
Topics: Aged; Aspirin; Biomarkers; Case-Control Studies; Coronary Artery Bypass, Off-Pump; Drug Administration Schedule; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Postoperative Care; Postoperative Period; Thrombosis; Thromboxane B2 | 2012 |
Aspirin resistance may be associated with adverse pregnancy outcomes.
Topics: Adult; Aspirin; Cesarean Section; Drug Resistance; Female; Fetal Distress; Humans; Infant, Newborn; Infant, Small for Gestational Age; Lupus Erythematosus, Systemic; Obstetric Labor, Premature; Parity; Platelet Aggregation Inhibitors; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Thromboxane B2; Young Adult | 2011 |
Evaluation of effects of low-dose aspirin administration on urinary thromboxane metabolites in healthy dogs.
Topics: Animals; Aspirin; Dogs; Enzyme-Linked Immunosorbent Assay; Female; Male; Platelet Aggregation Inhibitors; Thromboxane B2 | 2011 |
Aspirin extrusion from human platelets through multidrug resistance protein-4-mediated transport: evidence of a reduced drug action in patients after coronary artery bypass grafting.
Topics: Adult; Aspirin; Biological Transport; Blood Platelets; Cells, Cultured; Coronary Artery Bypass; Cyclic AMP; Cyclooxygenase 1; Dinoprostone; Drug Interactions; Drug Resistance; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Propionates; Prostaglandin-Endoperoxide Synthases; Quinolines; RNA, Small Interfering; Salicylic Acid; Thromboxane B2 | 2011 |
Evaluation of aspirin's effect on platelet function early after coronary artery bypass grafting.
Topics: Aged; Aspirin; Blood Platelets; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Thromboxane B2 | 2012 |
Urinary 11-dehydro-thromboxane B₂ and 2,3-dinor-6-keto-prostaglandin-F₁α in healthy post-menopausal and pre-menopausal women receiving aspirin 100 mg.
Topics: Adult; Aspirin; Cardiovascular Diseases; Female; Humans; Middle Aged; Platelet Aggregation Inhibitors; Postmenopause; Premenopause; Prostaglandins F; Thromboxane B2 | 2012 |
In vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D2: is this a new immediate-release therapeutic option for niacin?
Topics: Animals; Apolipoproteins B; Aspirin; Blood Glucose; Chemistry, Pharmaceutical; Cholesterol, LDL; Cyclooxygenase Inhibitors; Hyperglycemia; Hypolipidemic Agents; Isosorbide; Lipid Metabolism; Lipids; Macaca fascicularis; Models, Biological; Niacin; Postprandial Period; Prodrugs; Prostaglandin D2; Salicylates; Thromboxane B2; Triglycerides | 2012 |
The purification step is not crucial in EIA measurements of thromboxane B2 and 11-dehydrothromboxane B2 in human plasma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cardiovascular Diseases; Humans; Immunoenzyme Techniques; Platelet Activation; Prognosis; Reagent Kits, Diagnostic; Reproducibility of Results; Solid Phase Extraction; Thromboxane B2 | 2012 |
Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Biomarkers; Blood Platelets; Disease Models, Animal; Down-Regulation; Humans; Inflammation Mediators; Leukocytes; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Piperazines; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Selenoprotein P; Shock, Septic; Thiophenes; Thromboxane B2; Tumor Necrosis Factor-alpha | 2012 |
Increased platelet aggregation and serum thromboxane levels in aspirin-treated patients with prior myocardial infarction.
Topics: Aged; Aspirin; Coronary Artery Disease; Disease Progression; Drug Resistance; Female; Humans; Male; Middle Aged; Myocardial Infarction; P-Selectin; Platelet Aggregation; Thromboxane B2 | 2012 |
On aspirin treatment but not baseline thromboxane B2 levels predict adverse outcomes in patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aspirin; Humans; Thromboxane B2 | 2012 |
Metabolomic investigation of the anti-platelet aggregation activity of ginsenoside Rk₁ reveals attenuated 12-HETE production.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ginsenosides; Male; Membrane Proteins; Metabolome; Metabolomics; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Principal Component Analysis; Protein Transport; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 2012 |
The effect of selected pre-analytical phase variables on plasma thromboxane A₂ measurements in humans.
Topics: Anticoagulants; Aspirin; Blood Platelets; Citrates; Cyclooxygenase Inhibitors; Humans; Immunoenzyme Techniques; Platelet Aggregation Inhibitors; Specimen Handling; Temperature; Thromboxane A2; Thromboxane B2; Time Factors | 2013 |
Ibudilast, a phosphodiesterase inhibitor, in combination with low-dose aspirin potently inhibits guinea pig carotid artery thrombosis without extending bleeding time and causing gastric mucosal injury.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Bleeding Time; Carotid Artery Thrombosis; Drug Therapy, Combination; Gastric Mucosa; Guinea Pigs; Immunoenzyme Techniques; Indicators and Reagents; Male; Mice; Phosphodiesterase Inhibitors; Photochemistry; Platelet Aggregation Inhibitors; Pyridines; Rolipram; Salicylic Acid; Stomach Diseases; Thromboxane B2 | 2012 |
Platelet response to aspirin in Chinese stroke patients is independent of genetic polymorphisms of COX-1 C50T and COX-2 G765C.
Topics: Aged; Aspirin; Base Sequence; Blood Platelets; China; Cyclooxygenase 1; Cyclooxygenase 2; DNA Primers; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Platelet Aggregation; Polymerase Chain Reaction; Prospective Studies; Stroke; Thromboxane B2 | 2013 |
Theoretical investigation of aspirin dosage regimen to exhibit optimal antiplatelet effects and decrease risk of upper gastrointestinal lesions.
Topics: Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrointestinal Diseases; Models, Biological; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2012 |
A comparison of VerifyNowR with PlateletMappingR--detected aspirin resistance and correlation with urinary thromboxane.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Biological Assay; Blood Platelets; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Risk Assessment; Risk Management; Thrombelastography; Thromboxane B2 | 2013 |
Reduced antiplatelet effect of aspirin is associated with low-grade inflammation in patients with coronary artery disease.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; C-Reactive Protein; Coronary Artery Disease; Cross-Sectional Studies; Cyclooxygenase 1; Drug Resistance; Female; Humans; Inflammation; Inflammation Mediators; Interleukin-6; Linear Models; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Thromboxane B2; Treatment Outcome | 2013 |
Aspirin nonresponders in patients with ischaemic stroke.
Topics: Aspirin; Brain Ischemia; Female; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Survival Analysis; Thromboxane B2; Treatment Outcome | 2013 |
Association of plasma concentrations of salicylic acid and high on ASA platelet reactivity in type 2 diabetes patients.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Chromatography, High Pressure Liquid; Coronary Artery Disease; Cyclooxygenase 1; Diabetes Mellitus, Type 2; Drug Resistance; Female; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Platelet Function Tests; Poland; Predictive Value of Tests; Prospective Studies; Risk Factors; Salicylic Acid; Thromboxane B2 | 2013 |
Confirmation of reported aspirin use in community studies: utility of serum thromboxane B2 measurement.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Drug Monitoring; Female; Humans; Immunoenzyme Techniques; Male; Medication Adherence; Middle Aged; Thromboxane B2 | 2014 |
Differential impact of inflammation on six laboratory assays measuring residual arachidonic acid-inducible platelet reactivity during dual antiplatelet therapy.
Topics: Aged; Arachidonic Acids; Aspirin; Blood Platelets; C-Reactive Protein; Electrochemistry; Female; Humans; Immunoassay; Inflammation; Interleukin-6; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Risk Factors; Thromboxane B2 | 2013 |
"Aspirin resistance" in ischemic stroke: insights using short thrombelastography.
Topics: Aged; Aged, 80 and over; Aspirin; Biomarkers; Brain Ischemia; Cytokines; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Stroke; Thrombelastography; Thromboxane B2 | 2013 |
Aspirin augments carotid-cardiac baroreflex sensitivity during muscle mechanoreflex and metaboreflex activation in humans.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arterial Pressure; Aspirin; Baroreflex; Chemoreceptor Cells; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Female; Heart Rate; Humans; Isometric Contraction; Male; Mechanoreceptors; Mechanotransduction, Cellular; Muscle, Skeletal; Reflex, Stretch; Thromboxane A2; Thromboxane B2; Time Factors | 2013 |
Factors influencing multiplate whole blood impedance platelet aggregometry measurements, during aspirin treatment in acute ischemic stroke: a pilot study.
Topics: Adult; Aged; Aspirin; Blood Platelets; Brain Ischemia; C-Reactive Protein; Cholesterol, HDL; Clopidogrel; Electric Impedance; Female; Fibrinogen; Glycated Hemoglobin; Humans; Leukocyte Count; Leukocytes; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stroke; Thromboxane B2; Ticlopidine; von Willebrand Factor | 2013 |
Fatty acids and TxA(2) generation, in the absence of platelet-COX-1 activity.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Cardiovascular Diseases; Chromatography, Liquid; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Fatty Acids, Omega-3; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; Smoking; Tandem Mass Spectrometry; Thromboxane A2; Thromboxane B2 | 2014 |
Variation in thromboxane B2 concentrations in serum and plasma in patients taking regular aspirin before and after clopidogrel therapy.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thromboxane B2; Ticlopidine; Treatment Outcome | 2015 |
Acetylsalicylic acid enhances tachyphylaxis of repetitive capsaicin responses in TRPV1-GFP expressing HEK293 cells.
Topics: Acetylation; Analgesics; Animals; Aspirin; Blood Platelets; Calcium; Capsaicin; Cyclooxygenase 1; Green Fluorescent Proteins; HEK293 Cells; Humans; Rats; Recombinant Fusion Proteins; Tachyphylaxis; Thromboxane B2; TRPV Cation Channels | 2014 |
Reduced antiplatelet effect of aspirin during 24 hours in patients with coronary artery disease and type 2 diabetes.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Time Factors; Treatment Outcome | 2015 |
Statin therapy and thromboxane generation in patients with coronary artery disease treated with high-dose aspirin.
Topics: Aged; Aspirin; Biomarkers; Blood Coagulation; Chi-Square Distribution; Coronary Artery Disease; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Lipids; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Platelet Aggregation Inhibitors; Proportional Hazards Models; Risk Factors; Sex Factors; Thrombelastography; Thromboxane B2; Treatment Outcome; Ultracentrifugation | 2014 |
Association of cyclooxygenase-2 genetic variant with cardiovascular disease.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aspirin; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; Heterozygote; Humans; Male; Multicenter Studies as Topic; Myocardial Infarction; Polymorphism, Genetic; Prospective Studies; Randomized Controlled Trials as Topic; Stroke; Thromboxane B2 | 2014 |
Circulating myeloid-related protein-8/14 is related to thromboxane-dependent platelet activation in patients with acute coronary syndrome, with and without ongoing low-dose aspirin treatment.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Calgranulin A; Calgranulin B; Chronic Disease; Dinoprost; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Activation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2014 |
Circulating dickkopf-1 in diabetes mellitus: association with platelet activation and effects of improved metabolic control and low-dose aspirin.
Topics: Aged; Arginine; Aspirin; Biomarkers; Cardiovascular Diseases; Case-Control Studies; CD40 Ligand; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Intercellular Signaling Peptides and Proteins; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Thromboxane B2; Wnt Signaling Pathway | 2014 |
Increased platelet expression of glycoprotein IIIa following aspirin treatment in aspirin-resistant but not aspirin-sensitive subjects.
Topics: Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cohort Studies; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Resistance; Female; Healthy Volunteers; Humans; Integrin beta3; Male; Platelet Aggregation; Thromboxane B2 | 2014 |
Gastric-sparing nitric oxide-releasable 'true' prodrugs of aspirin and naproxen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Drug Design; Drug Stability; Gastric Mucosa; Half-Life; Humans; Naproxen; Nitrates; Nitric Oxide; Platelet Aggregation Inhibitors; Prodrugs; Rats; Rats, Sprague-Dawley; ROC Curve; Thromboxane B2 | 2014 |
Aspirin resistance in adult patients after Fontan surgery.
Topics: Adult; Aspirin; CD40 Antigens; Drug Resistance; Endothelium, Vascular; Female; Fontan Procedure; Heart Defects, Congenital; Humans; Inflammation; Male; Neutrophil Activation; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Count; Postoperative Complications; Thrombosis; Thromboxane B2 | 2015 |
Monitoring aspirin therapy in children after interventional cardiac catheterization: laboratory measures, dose response, and clinical outcomes.
Topics: Adolescent; Arachidonic Acids; Aspirin; Cardiac Catheterization; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Monitoring; Drug Resistance; Female; Humans; Infant; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Thromboxane B2; Young Adult | 2015 |
Arachidonic acid-stimulated platelet tests: Identification of patients less sensitive to aspirin treatment.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Platelets; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Retrospective Studies; Thromboxane B2 | 2015 |
Dual antiplatelet response during PCI: VerifyNow P2Y12 predicts myocardial necrosis and thromboxane B2 generation confirms wide variation in aspirin response.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Myocardium; Necrosis; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Purinergic P2Y12; Regression Analysis; Thromboxane B2; Ticlopidine | 2015 |
Aspirin resistance in children and young adults with splenectomized thalassemia diseases.
Topics: Adolescent; Aspirin; Blood Coagulation; Child; Child, Preschool; Drug Resistance; Female; Fibrin Fibrinogen Degradation Products; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Splenectomy; Thalassemia; Thromboembolism; Thromboxane B2; Young Adult | 2015 |
Does the response to aspirin and clopidogrel vary over 6 months in patients with ischemic heart disease?
Topics: Aged; Area Under Curve; Aspirin; Biomarkers; Blood Platelets; Clopidogrel; Drug Therapy, Combination; England; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Receptors, Purinergic P2Y12; Reproducibility of Results; ROC Curve; Thrombelastography; Thromboxane B2; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Dual antiplatelet therapy for PCI: Are we tailored to all?
Topics: Aspirin; Female; Humans; Male; Myocardium; Necrosis; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Receptors, Purinergic P2Y12; Thromboxane B2 | 2015 |
Calprotectin and platelet aggregation in patients with stable coronary artery disease.
Topics: Aged; Aspirin; C-Reactive Protein; Coronary Artery Disease; Cross-Sectional Studies; Female; Humans; Interleukin-6; Leukocyte L1 Antigen Complex; Male; Medication Adherence; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2015 |
Determinants of reduced antiplatelet effect of aspirin in patients with stable coronary artery disease.
Topics: Aged; Aspirin; Body Mass Index; Coronary Artery Disease; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Thromboxane B2 | 2015 |
Comparison of aspirin and indobufen in healthy volunteers.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Cross-Over Studies; Drug Administration Schedule; Female; Healthy Volunteers; Humans; Isoindoles; Male; Middle Aged; Phenylbutyrates; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 2016 |
Comparison between urinary 11-dehydrothromboxane B2 detection and platelet Light Transmission Aggregometry (LTA) assays for evaluating aspirin response in elderly patients with coronary artery disease.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Platelets; Coronary Artery Disease; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane B2; Treatment Outcome | 2015 |
Suppressive effect of citalopram on plasma concentrations of thromboxane B2.
Topics: Aged; Aged, 80 and over; Aspirin; Citalopram; Female; Humans; Male; Middle Aged; Selective Serotonin Reuptake Inhibitors; Thromboxane B2 | 2015 |
Aspirin response: Differences in serum thromboxane B2 levels between clinical studies.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Cardiovascular Diseases; Chromatography, Liquid; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Tandem Mass Spectrometry; Thromboxane B2; Treatment Outcome | 2016 |
Relationship between high on aspirin platelet reactivity and oxidative stress in coronary artery by-pass grafted patients.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Coronary Artery Bypass; Coronary Artery Disease; Coronary Vessels; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Oxidative Stress; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2016 |
The monitoring of antiaggregation effect of acetylsalicylic acid therapy by measuring serum thromboxane B2 in patients with coronary artery bypass grafting.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Case-Control Studies; Coronary Artery Bypass; Coronary Artery Disease; Drug Administration Schedule; Drug Monitoring; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane B2 | 2016 |
[Correlation between the level of the urinary 11-dehydrothromboxane B2 and the clinical efficacy of aspirin in patients with type 2 diabetes and coronary artery disease].
Topics: Aspirin; Beijing; Blood Platelets; Coronary Artery Disease; Diabetes Mellitus, Type 2; Humans; Platelet Aggregation Inhibitors; Prospective Studies; Thromboxane B2; Treatment Outcome | 2015 |
The lack of aspirin resistance in patients with coronary artery disease.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Coronary Artery Disease; Cyclooxygenase 1; Cyclooxygenase 2; Drug Resistance; Female; Gene Expression Regulation, Enzymologic; Humans; Male; Middle Aged; Platelet Aggregation; RNA, Messenger; Thromboxane B2 | 2016 |
Increases in ambient particulate matter air pollution, acute changes in platelet function, and effect modification by aspirin and omega-3 fatty acids: A panel study.
Topics: Adult; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Aspirin; Blood Platelets; Collagen; Diabetes Mellitus, Type 2; Fatty Acids, Omega-3; Female; Humans; Male; Middle Aged; Particle Size; Particulate Matter; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane B2; Weather | 2016 |
Cardiovascular events occur independently of high on-aspirin platelet reactivity and residual COX-1 activity in stable cardiovascular patients.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cardiovascular Diseases; Cohort Studies; Cyclooxygenase 1; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Risk Factors; Secondary Prevention; Thromboxane B2 | 2016 |
Multiple Electrode Aggregometry is an adequate method for aspirin response testing in myeloproliferative neoplasms and differentiates the mechanisms of aspirin resistance.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Platelets; Drug Resistance; Electrodes; Female; Humans; Male; Middle Aged; Myeloproliferative Disorders; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Thromboxane B2; Young Adult | 2016 |
Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Aged; Asian People; Aspirin; ATP Binding Cassette Transporter, Subfamily B; Blood Platelets; Brain Ischemia; Female; Gene Frequency; Genetic Association Studies; Humans; Linkage Disequilibrium; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Receptors, Cell Surface; Receptors, Thromboxane A2, Prostaglandin H2; Stroke; Thromboxane B2; Treatment Failure | 2016 |
Oxidative stress reflected by increased F
Topics: Aged; Aspirin; Coronary Artery Disease; Cross-Sectional Studies; Cyclooxygenase 1; Dinoprost; F2-Isoprostanes; Female; Humans; Male; Middle Aged; Oxidative Stress; Platelet Aggregation Inhibitors; Thromboxane B2 | 2016 |
The time between venepuncture and blood incubation is critical for serum thromboxane B2 synthesis.
Topics: Aspirin; Thromboxane B2; Thromboxanes | 2017 |
Residual thromboxane activity and oxidative stress: influence on mortality in patients with stable coronary artery disease.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Biomarkers; Cause of Death; Coronary Artery Disease; Cyclooxygenase Inhibitors; Dinoprost; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Middle Aged; Oxidative Stress; Prognosis; Prospective Studies; Risk Factors; Survival Rate; Texas; Thromboxane B2; Time Factors | 2017 |
Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin-Dependent Effects on Platelet Aggregation Pathways.
Topics: Adenosine Diphosphate; Adult; Alleles; Amish; Aspirin; Biomarkers; Blood Platelets; Collagen; Epinephrine; Female; Genotype; Healthy Volunteers; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prospective Studies; Receptors, Cell Surface; Thromboxane B2 | 2017 |
Type 2 Diabetes, Obesity, and Aspirin Responsiveness.
Topics: Aspirin; Diabetes Mellitus, Type 2; Humans; Obesity; Platelet Aggregation Inhibitors; Thromboxane B2 | 2017 |
Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A
Topics: Aged; Aspirin; Cardiovascular Agents; Cardiovascular Diseases; Carrier Proteins; Contactins; Europe; Female; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Genome-Wide Association Study; Haplotypes; Humans; Incidence; Male; Middle Aged; Multicenter Studies as Topic; Phenotype; Polymorphism, Single Nucleotide; Primary Prevention; Progression-Free Survival; Randomized Controlled Trials as Topic; Risk Factors; RNA-Binding Proteins; Thromboxane A2; Thromboxane B2; Time Factors; White People | 2018 |
Panax quinquefolius saponins combined with dual antiplatelet drug therapy alleviate gastric mucosal injury and thrombogenesis through the COX/PG pathway in a rat model of acute myocardial infarction.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Platelets; Clopidogrel; Cyclooxygenase 2; Gastric Mucosa; Male; Myocardial Infarction; Myocardium; Panax; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Saponins; Thromboxane B2; Ticlopidine; Tissue Plasminogen Activator; Vascular Endothelial Growth Factor A | 2018 |
The Effects of Exercise, Aspirin, and Celecoxib in an Atherogenic Environment.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Celecoxib; Cells, Cultured; Epoprostenol; Exercise; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Nitric Oxide Synthase Type III; Stress, Mechanical; Thromboxane B2; Tumor Necrosis Factor-alpha | 2018 |
Evaluation of the antithrombotic activity of Zhi-Xiong Capsules, a Traditional Chinese Medicinal formula, via the pathway of anti-coagulation, anti-platelet activation and anti-fibrinolysis.
Topics: Acute Disease; Animals; Anticoagulants; Antithrombins; Aspirin; Blood Coagulation; Capsules; Carotid Arteries; Chlorides; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Ferric Compounds; Fibrinolysis; Heparin; Lung; Mice; Platelet Activation; Platelet Aggregation; Prostaglandins F; Pulmonary Embolism; Rabbits; Rats, Sprague-Dawley; Thrombolytic Therapy; Thrombosis; Thromboxane B2 | 2018 |
Immature platelets and antiplatelet therapy response to aspirin in Kawasaki disease.
Topics: Aspirin; Blood Platelets; CD40 Ligand; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Humans; Infant; Male; Mucocutaneous Lymph Node Syndrome; P-Selectin; Platelet Aggregation Inhibitors; Thromboxane B2 | 2018 |
[The experimental study of simvastatin on improving aspirin resistance in diabetic rats].
Topics: Animals; Aspirin; Diabetes Mellitus, Experimental; Endothelium, Vascular; Epoprostenol; Male; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Simvastatin; Thromboxane B2 | 2016 |
Diabetes and Platelet Response to Low-Dose Aspirin.
Topics: Adult; Aspirin; Blood Platelets; Coronary Artery Disease; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane B2; Treatment Outcome | 2018 |
Malondialdehyde Assay in the Evaluation of Aspirin Antiplatelet Effects.
Topics: Aged; Aspirin; Blood Platelets; Case-Control Studies; Female; Humans; Male; Malondialdehyde; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane B2 | 2019 |
[Anti-platelet aggregation and anti-thrombotic mechanism of Trichosanthis Fructus combined with aspirin based on network pharmacology].
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Cyclic AMP; Drugs, Chinese Herbal; Fruit; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Signal Transduction; Thrombosis; Thromboxane B2; Trichosanthes | 2019 |
miR-34b-3p May Promote Antiplatelet Efficiency of Aspirin by Inhibiting Thromboxane Synthase Expression.
Topics: Aged; Aged, 80 and over; Aspirin; Biomarkers, Pharmacological; Blood Platelets; Cardiovascular Diseases; Cell Line; Cell Proliferation; Drug Resistance; Female; Gene Expression Regulation; Humans; Male; Megakaryocytes; MicroRNAs; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Thromboxane-A Synthase | 2019 |
Aspirin & clopidogrel non-responsiveness & its association with genetic polymorphisms in patients with myocardial infarction.
Topics: Aged; Alleles; Aspirin; CD40 Ligand; Clopidogrel; Cyclooxygenase 1; Cytochrome P-450 Enzyme System; Dual Anti-Platelet Therapy; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Polymorphism, Genetic; Receptors, Purinergic P2Y12; Thromboxane B2 | 2019 |
Determinants of aspirin resistance in patients with type 2 diabetes.
Topics: Aged; Arachidonic Acid; Aspirin; C-Reactive Protein; Coronary Artery Disease; Diabetes Mellitus, Type 2; Drug Resistance; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Insulin Resistance; Interleukin-10; Interleukin-6; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Severity of Illness Index; Thrombopoietin; Thromboxane B2; Tumor Necrosis Factor-alpha; Vascular Calcification | 2020 |
The relationship of a Prothrombin G20210A mutation or a factor V Leiden mutation and on-aspirin platelet (re-)activity.
Topics: Adult; Aspirin; Case-Control Studies; Cohort Studies; Factor V; Female; Heterozygote; Humans; Middle Aged; Mutation; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prothrombin; Thromboxane B2 | 2020 |
Residual platelet reactivity in low-dose aspirin-treated patients with class 1 obesity.
Topics: Aged; Angioplasty; Aspirin; Biomarkers; Blood Platelets; Cardiovascular Diseases; Dual Anti-Platelet Therapy; Female; Flow Cytometry; Humans; Male; Middle Aged; Obesity; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Thromboxane B2; Time Factors; Treatment Outcome | 2021 |
Urinary Thromboxane B2 and Lethal Prostate Cancer in African American Men.
Topics: Aspirin; Black or African American; Humans; Male; Prostatic Neoplasms; Thromboxane A2; Thromboxane B2 | 2022 |
The Synergistic Effect of
Topics: Animals; Arachidonic Acid; Aspirin; Chromatography, High Pressure Liquid; Cyclic AMP; Drug Synergism; Ginkgo biloba; Male; Mass Spectrometry; Plant Extracts; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, G-Protein-Coupled; Thromboxane B2 | 2021 |
Urinary 11-dehydrothromboxane B2 aspirin efficacy testing is sensitive to perioperative inflammation in pediatric solid-organ transplant patients.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Inflammation; Organ Transplantation; Pediatrics; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Thromboxane B2; Young Adult | 2022 |
Serum thromboxane B2 but not soluble P-selectin levels identify ischemic stroke patients with persistent platelet reactivity while on aspirin therapy.
Topics: Aspirin; Brain Ischemia; Humans; Ischemic Stroke; P-Selectin; Thromboxane B2 | 2021 |
Less Thromboxane, Longer Life.
Topics: Aspirin; Blood Platelets; Humans; Thromboxane B2; Thromboxanes | 2022 |
The impact of enteric coating of aspirin on aspirin responsiveness in patients with suspected or newly diagnosed ischemic stroke: prospective cohort study: results from the (ECASIS) study.
Topics: Aspirin; Gastrointestinal Hemorrhage; Glycated Hemoglobin; Humans; Ischemic Stroke; Platelet Aggregation Inhibitors; Prospective Studies; Thromboxane B2 | 2022 |