aspirin has been researched along with thromboxane a2 in 588 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 215 (36.56) | 18.7374 |
| 1990's | 188 (31.97) | 18.2507 |
| 2000's | 109 (18.54) | 29.6817 |
| 2010's | 62 (10.54) | 24.3611 |
| 2020's | 14 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Vargaftig, BB | 2 |
| de Gaetano, G; Livio, M; Villa, S | 1 |
| Kester, R; Penny, A; Rajah, SM | 1 |
| Burch, JW; Majerus, PW | 1 |
| Cervini, L; Geroldi, D | 1 |
| Moncada, S; Vane, JR | 5 |
| Marcus, AJ | 2 |
| Kam, ST; Portoghese, PS | 1 |
| Waitzman, MB | 1 |
| Vane, JR | 1 |
| Kuratowska, Z | 1 |
| Gryglewski, RJ; Korbut, R; Ocetkiewicz, A; Spławiński, J; Swies, J; Wojtaszek, B | 1 |
| Gryglewski, RJ; Szczeklik, AJ | 1 |
| Korbut, R; Moncada, S | 1 |
| Machleder, HI | 1 |
| Benveniste, J; Chignard, M; Le Couedic, JP; Tence, M; Vargaftig, BB | 1 |
| Amezcua, JL; Moncada, S | 1 |
| Köln, RB | 1 |
| Dusting, GJ; Moncada, S; Mullane, KM; Salmon, JA; Vane, JR | 1 |
| Bergamaschi, M; Ceserani, R; Pierucci, L; Pogliani, E; Spelta, A | 1 |
| Grodzińska, L; Gryglewski, RJ; Marcinkiewicz, E; Musiał, J; Serwońska, M; Szczeklik, A | 1 |
| Amezcua, JL; Moncada, S; O'Grady, J; Salmon, JA | 1 |
| Chignard, M; Lefort, J; Vargaftig, BB | 1 |
| Murao, S; Uchida, Y; Yoshimoto, N | 1 |
| Amezcua, JL; Moncada, S; Parsons, M | 1 |
| Schröder, H; Schrör, K | 1 |
| Balsano, F; Censi, C; Davì, G; Violi, F | 1 |
| Aranyi, Z; Ballagi-Pordány, G; Hadházy, P; Koltai, MZ; Pogátsa, G; Rösen, P | 1 |
| Bizzi, B; Castellana, MA; Ciabattoni, G; Landolfi, R; Patrignani, P; Patrono, C; Pogliani, E | 1 |
| FitzGerald, GA; Shipp, E | 1 |
| Hayashi, Y; Nakahama, H; Nakanishi, T; Shimizu, S; Sugita, M; Takiguchi, A; Uyama, O; Yamamoto, S | 1 |
| Carroll, RC; Rubinstein, E; Urso, I | 1 |
| Kawano, K; Kimura, B; Konno, S; Tamura, K; Tohgi, H | 1 |
| Cámara, S; De La Cruz, JP; Frutos, MA; Sánchez De La Cuesta, F | 1 |
| Araki, S; Fukuchi, M; Nakashima, M; Uematsu, T | 1 |
| Bremer, HA; Wallenburg, HC | 1 |
| Dotts, IB; Shuev, BV | 1 |
| Hubbell, JA; Wagner, WR | 1 |
| Albanese, S; Bianchi, C; Ciabattoni, G; Coppola, E; Lanza, GA; Natale, A; Rebuzzi, AG | 1 |
| Matsumoto, T; Toda, N; Yoshida, K | 1 |
| Barrow, DV; Gross, PL; Packham, MA; Rand, ML | 2 |
| Miura, K; Okumura, M; Yamamoto, K; Yamanaka, S; Yukimura, T | 1 |
| Averna, M; Barbagallo, C; Catalano, I; Ciabattoni, G; Davì, G; Ganci, A; Notarbartolo, A; Patrono, C | 1 |
| Ohkubo, H; Ohmuro, S; Sasahara, T; Taga, F; Uchida, H | 1 |
| Boucheix, C; Carroll, RC; Rubinstein, E; Urso, I | 1 |
| Bastida, E; Cardona, M; Escolar, G; Ordinas, A; Roig, E; Sanz, G | 1 |
| Bottoms, SF; Mammen, EF; Saleh, AA | 1 |
| Bauer, E; Lüscher, TF; Stulz, P; Turina, M; von Segesser, L; Yang, ZH | 1 |
| Kinlough-Rathbone, RL; Packham, MA; Rand, ML; Ruben, DH | 1 |
| Aznar, J; Broekman, MJ; Marcus, AJ; Martinez-Sales, V; Portoles, M; Safier, LB; Santos, MT; Valles, J | 1 |
| Jimenez, AH; Muller, JE; Stubbs, ME; Tofler, GH; Williams, GH; Winther, K | 1 |
| Bakhoviddinova, GSh | 1 |
| Abbas, NA; Hirschelmann, R; Mest, HJ; Taube, C | 1 |
| Charman, SA; Charman, WN; FitzGerald, GA; Lupinetti, M | 1 |
| Khosseĭn Shakhavat, AF; Shelest, AN; Shushliapin, OI | 1 |
| Morgenstern, E; Patscheke, H; Ruf, A | 1 |
| Evsiukova, EV | 1 |
| Karasawa, A; Kubo, K; Shirakura, S | 1 |
| Charman, W; Clarke, R; Fitzgerald, DJ; FitzGerald, GA; Funk, C; Furci, L; Moran, N; Murray, R | 1 |
| Keery, RJ; Lumley, P; Watts, IS; Wharton, KA; White, BP | 1 |
| Gréen, K; Vesterqvist, O | 1 |
| Carreras, L; Falcon, C; Lellouche, F; Maclouf, J | 1 |
| Ciabattoni, G; Davì, G; Patrono, C | 2 |
| Drvota, V; Gréen, K; Vesterqvist, O | 1 |
| Abbate, R; Poggesi, L; Prisco, D; Rostagno, C | 1 |
| Danchin, N; Heyndrickx, GR; Mast, EG; Rensing, BJ; Rutsch, W; Serruys, PW; Stibbe, J; Vos, J; Wijns, W | 1 |
| Iida, N | 1 |
| Braden, GA; FitzGerald, GA; Knapp, HR | 1 |
| Clarke, RJ; FitzGerald, GA; Mayo, G; Price, P | 1 |
| McCall, NT; Muller, JE; Schafer, AI; Tofler, GH; Williams, GH | 1 |
| Bonavita, MS; Ghiselli, A; Iuliano, L; Praticò, D; Violi, F | 1 |
| Cullaré, C; de Castellarnau, C; de Moragas, JM; Puig, L; Solá, J; Vila, L | 1 |
| Go, K; Goda, T; Matsui, Y; Sakuma, M; Yasuda, K | 1 |
| Ladnyĭ, AI; Malaia, LT | 1 |
| Fitzgerald, DJ; FitzGerald, GA; Mayo, G; Murray, R; Rocki, W | 1 |
| Fujiwara, M; Kurahashi, K; Shimaji, H; Shirahase, H; Usui, H | 2 |
| Dekker, GA; Makovitz, JW; Rotmans, N; Wallenburg, HC | 1 |
| Feng, HF; Zhang, YH; Zhao, X | 1 |
| Bollinger, A | 1 |
| Hornberger, W; Patscheke, H; Zehender, H | 1 |
| Benthin, G; Carlsson, I; Petersson, AS; Wennmalm, A | 1 |
| Pinto, A; Sorrentino, L; Sorrentino, R | 1 |
| Bisacci, R; Boschetti, E; Cipolloni, S; Costantini, V; Nenci, GG; Talpacci, A; Tristaino, B | 1 |
| Furui, H; Furumichi, T; Hayashi, H; Saito, H; Suzuki, T; Yamada, Y; Yamauchi, K; Yokota, M | 1 |
| Alessandri, C; Balsano, F; Cordova, C; Ghiselli, A; Iuliano, L; Pratico, D; Violi, F | 1 |
| Aoyama, T; Hattori, R; Kawai, C; Yui, Y | 1 |
| Markov, KhM | 1 |
| Higashihara, M; Kariya, T; Kume, S; Matsumoto, Y; Ozaki, Y; Yatomi, Y | 1 |
| Ballagi-Pordány, G; Hadházy, P; Koltai, MZ; Pogátsa, G; Rösen, P | 1 |
| Braun, M; Schrör, K | 1 |
| Patrono, C | 2 |
| Bech, FR; Cronenwett, JL; Freeman, DH; McDaniel, MD; Ogletree, ML | 1 |
| Anderson, HV; Buja, LM; De Clerck, F; Golino, P; NcNatt, JM; Rosolowsky, M; Willerson, JT; Yao, SK | 1 |
| Covatto, RH; Niewiarowski, S | 1 |
| Fasciolo, JC; Lama, MC; Nolly, H; Vargas, L | 1 |
| de Gaetano, G | 1 |
| Derian, CK; Friedman, PA; Gould, RJ | 1 |
| Bochner, F; Duncan, EM; Lloyd, JV; Siebert, DM; Somogyi, AA; Wilson, KM | 1 |
| Kinlough-Rathbone, RL; Mustard, JF; Packham, MA; Vickers, JD | 1 |
| Patscheke, H | 1 |
| Viinikka, L | 1 |
| Iwata, I; Iwata, M; Masuhiro, K; Mitsuda, N; Nishino, E; Takagi, T; Tanizawa, O | 1 |
| Maseri, A | 1 |
| Ayaziki, K; Okamura, T; Toda, N | 1 |
| Boucheix, C; Carroll, RC; Worthington, RE | 1 |
| Bath, PM; Kristensen, SD; Martin, JF | 1 |
| Boncinelli, S; Castellani, S; Chelucci, GL; Cresci, F; Gensini, GF; Linden, M; Lorenzi, P; Marsili, M; Merciai, V; Rostagno, C | 1 |
| Averna, M; Catalano, I; Ciabattoni, G; Davì, G; Notarbartolo, A; Patrono, C; Strano, A | 1 |
| Brunelli, C; Caponnetto, S; Galassi, AR; Hackett, D; Ianetti, M; Lipkin, D; Maseri, A; Patrono, C; Spallarossa, P; Vejar, M | 1 |
| Maderna, P; Paoletti, R; Tremoli, E | 1 |
| Fujiwara, M; Kurahashi, K; Manabe, K; Shirahase, H; Usui, H | 1 |
| Awano, K; Fukuzaki, H; Yokoyama, M | 1 |
| Barradas, MA; Dandona, P; Hoffbrand, AV; Jeremy, JY; Kontoghiorghes, GJ; Mikhailidis, DP | 1 |
| Alessandri, C; Balsano, F; Ghiselli, A; Guzzo, A; Praticò, D; Violi, F | 1 |
| Cieslar, P; Jáchymová, M; Knotková, V; Nĕmecek, K; Pelèska, J; Petrů, I; Pick, P; Tomasy, M | 1 |
| Brenner, B; Eichler, HG; Heistinger, M; Kyrle, PA; Lechner, K; Marosi, L; Minar, E | 1 |
| Catella, F; Fitzgerald, GA; Lupinetti, MD; Sheller, JR | 1 |
| Fitzgerald, DJ; FitzGerald, GA; Kerins, DM; Roy, L | 1 |
| Arosio, E; Guzzo, P; Lechi, A; Lechi, C; Minuz, P; Paluani, F; Sinigaglia, D | 1 |
| Grover, GJ; Schumacher, WA | 1 |
| Hatakeyama, H; Hori, Y; Kurosawa, A; Yamada, K | 1 |
| Baker, RC; Fish, HT; Fitzpatrick, FA | 1 |
| Ciabattoni, G; Cinotti, GA; Feriozzi, S; Mavrikakis, G; Patrignani, P; Patrono, C; Pecci, G; Pierucci, A; Simonetti, BM | 1 |
| Cairns, JA; Collins, R; Dalen, JE; Fuster, V; Harker, L; Hirsh, J; Salzman, EW | 1 |
| Egberg, N; Green, K; Lewin, J; Swedenborg, J; Vesterqvist, O | 1 |
| Barkai, G; Ben-Baruch, G; Blankstein, J; Goldenberg, M; Peleg, E; Rosenthal, T; Ruppin, E; Schiff, E; Tamarkin, M; Yahal, I | 1 |
| Ballerini, S; Benigni, A; Chiabrando, C; Fanelli, R; Frusca, T; Gregorini, G; Orisio, S; Piccinelli, A; Pinciroli, V; Valcamonico, A | 1 |
| Walsh, SW | 1 |
| McCulloch, RK; Rouse, IL; Summers, J; Vandongen, R | 1 |
| Gentry, PA; Ross, ML; Tremblay, RR | 1 |
| Fujiwara, M; Fukui, K; Kurahashi, K; Shirahase, H; Usui, H | 2 |
| Remuzzi, G | 1 |
| Edhag, O; Gréen, K; Henriksson, P; Rasmanis, G; Vesterqvist, O | 1 |
| Irwin, JT; Lane, IF; McCollum, CN; Peters, AM; Sinclair, M | 1 |
| FitzGerald, GA; Nowak, J | 1 |
| Hashimoto, Y; Kato, H; Kawamura, M; Kume, S; Naito, C; Oka, H; Teramoto, T; Watanabe, T | 1 |
| Botha, JH; Leary, WP; Robinson, KM | 1 |
| Abramson, S; Edelson, H; Haines, K; Herman, R; Kimmel, S; Korchak, H; Levin, RI; Ludewig, R; Rider, L; Weissmann, G | 1 |
| Krop, I; Lawson, D; Letts, LG; Mehta, J; Mehta, P | 1 |
| Bucchi, F; Cerletti, C; de Gaetano, G | 1 |
| Banga, HS; Brass, LF; Rittenhouse, SE; Simons, ER | 1 |
| Inoue, M; Kojima, T; Morikawa, M; Tsuboi, M | 2 |
| Köpernick, H; Mest, HJ; Schwarz, B | 1 |
| Vesterqvist, O | 1 |
| Barabás, K; Matkovics, B; Mézes, M | 1 |
| Ciabattoni, G; Cominelli, F; Gentilini, P; La Villa, G; Laffi, G; Mannelli, M; Patrignani, P; Pinzani, M | 1 |
| Emms, H; Lewis, GP | 1 |
| Bartolini, G; Chiricolo, M; Fidan, M; Franceschi, C; Guerrini, F; Minghetti, L; Orlandi, M; Tomasi, V | 1 |
| Cerletti, C; de Gaetano, G; Gambino, MC; Garattini, S; Marchi, S | 1 |
| Deykin, D; Faigel, D; Jakubowski, JA; Stampfer, MJ; Vaillancourt, R | 1 |
| Bochner, F; Lloyd, J | 1 |
| Bonati, M; Gaspari, F; Livio, M; Orisio, S; Remuzzi, G; Viganò, G | 1 |
| Le Breton, GC; Zaragoza, R | 1 |
| Abbate, R; Favilla, S; Gensini, GF; Neri Serneri, GG; Panetta, A; Pinto, S; Prisco, D | 1 |
| Rak, K; Török, I; Udvardy, M | 1 |
| Szczeklik, A | 1 |
| Andries, R; Bourgain, RH; Braquet, P; Decuyper, K | 1 |
| Hamasaki, Y; Ichimaru, T; Miyazaki, S; Tasaki, H | 1 |
| Cassina, G; Livio, M; Macconi, D; Morelli, C; Morzenti, G; Remuzzi, G | 1 |
| Patscheke, H; Stegmeier, K | 1 |
| Bochner, F; Lloyd, JV; Morris, PM; Siebert, DM; Williams, DB | 1 |
| Catella, F; Fitzgerald, DJ; FitzGerald, GA; Roy, L | 1 |
| Cerletti, C; de Gaetano, G; Dejana, E; Domanin, M; Latini, R; Lauri, D; Lorenzi, G; Marchi, S; Urso, R | 1 |
| Parkin, JD | 1 |
| Chen, ZJ; Gao, SW; Tao, SQ | 1 |
| Rotmans, N; Wallenburg, HC | 1 |
| Foreman, RK; James, MJ; Walsh, JA | 1 |
| Beckman, J; Klein, RC; Peake, G | 1 |
| Alessandri, C; Balsano, F; Ghiselli, A; Iuliano, L; Praticò, D; Violi, F | 1 |
| Barr, RD; Buchanan, MR; Gibson, BE; White, JG | 1 |
| Bochner, F; Duncan, EM; Herd, CM; Lloyd, JV; Rodgers, SE; Tunbridge, LJ | 1 |
| Bendtsen, F; Dupont, M; Engquist, A; Sørensen, JN | 1 |
| Kaplan, S; Marcoe, KF; Mathisen, SR; Sauvage, LR; Walker, MW; Wu, HD; Zammit, M | 1 |
| McCauley, FA; Wells, HD; Wilson, TW | 1 |
| Hulsman, LO; Kort, WJ; van Schalkwijk, WP; Weijma, IM; Westbroek, DL; Zondervan, PE | 1 |
| Sierakowski, S | 1 |
| Kääpä, P; Mäkilä, UM; Viinikka, L; Ylikorkala, O | 1 |
| Deykin, D; Hennekens, CH; Jakubowski, JA; Schafer, AI; Stampfer, MJ; Willett, WC | 1 |
| Carroll, SE; Thibert, MR | 1 |
| Gay, WA; Karwande, SV; Subramanian, VA; Weksler, BB | 1 |
| Merz, B | 1 |
| Eichler, HG; Jäger, U; Kyrle, PA; Lechner, K | 1 |
| de Groot, PG; Kallmann, R; Nieuwenhuis, HK; Sixma, JJ; van Gijn, J | 1 |
| Inaba, M; Ishii, J; Katayama, S; Kawazu, S; Maruno, Y; Omoto, A | 1 |
| Angoli, L; Bramucci, E; Bré, E; Corsico, G; De Servi, S; Ferrario, M; Ghio, S; Mussini, A; Poma, E; Rondanelli, R | 1 |
| Lawson, D; Mehta, J; Mehta, P; Ward, MB | 1 |
| Schrör, K; Verheggen, R | 1 |
| Dworski, R; Gajewski, P; Nizankowska, E; Splawinska, B; Splawinski, J; Szczeklik, A | 1 |
| FitzGerald, GA; Reilly, IA | 1 |
| Corrigan, JJ; Fenster, PE; Ring, ME | 1 |
| Bastida, E; Castillo, R; Escolar, G; Garrido, M; Ordinas, A; Rodríguez-Gómez, J | 1 |
| Cerletti, C; de Gaetano, G; de Marchi, F; Guarneri, L; Molinari, A; Pacei, E | 1 |
| Gay, WA; Subramanian, VA; Tack-Goldman, K; Weksler, BB | 1 |
| Wang, RL; Xu, DC; Xu, LN | 1 |
| Moncada, S | 3 |
| Toivanen, J; Viinikka, L; Ylikorkala, O | 2 |
| Colli, S; Maderna, P; Morazzoni, G; Stragliotto, E; Tremoli, E | 1 |
| Bernini, W; De Caterina, R; Donato, L; Filabozzi, P; Gazzetti, P; Giannessi, D; L'Abbate, A; Michelassi, C; Patrignani, P; Patrono, C | 2 |
| Colwell, JA; Halushka, PV; Mayfield, R | 1 |
| Carter, AJ; Heptinstall, S | 1 |
| Okuma, M | 1 |
| Gewirtz, H; Most, AS; Sasken, H; Steiner, M | 1 |
| Dhawan, BN; Dikshit, M; Srimal, RC; Srivastava, R | 1 |
| D'Angelo, A; Galli, G; Mannucci, PM; Pareti, FI; Sautebin, L; Smith, JB | 1 |
| Bevan, J; Cockbill, SR; Hanley, SP; Heptinstall, S | 2 |
| Born, GV; Shafi, S; Thorngren, M | 1 |
| Berti, F; Brunelli, G; Folco, GC; Omini, C; Rossoni, G; Viganó, T | 2 |
| Hiraku, S; Iizuka, K; Katsube, N; Kawasaki, A; Komatsu, H; Naito, J; Tsuboshima, M; Ujiie, A; Wakitani, K | 1 |
| Mitchell, JR | 1 |
| Amplatz, K; Bruhlmann, WF; Castaneda, F; Castaneda-Zuniga, WR; Cragg, AH; Einzig, S; Rysavy, JA; Shebuski, RJ; Zollikofer, CL | 1 |
| Biland, L; Bollinger, A; Brunner, U; Kappert, A; Krähenbühl, B; Mahler, F; Monti, M; Nachbur, B; Schneider, E; Widmer, LK | 1 |
| Kaplan, S; Marcoe, KF; Sauvage, LR; Wu, HD; Zammit, M | 1 |
| Hata, S; Koide, T; Matsushita, H; Mizukami, M; Nakano, M; Neichi, T; Noda, Y; Yamazaki, T | 1 |
| Birgens, HS; Hansen, MS | 1 |
| Köhler, P; Müller, M; Peskar, BA; Rösen, P; Schrör, K | 1 |
| Abbate, R; Galanti, G; Gensini, GF; Laureano, R; Neri Serheri, GG; Paoli, G | 1 |
| Borgeat, P; Picard, S; Roy, S; Sirois, P; Vallerand, P | 1 |
| Gaillard, JL; Kher, A; Lecompte, T; Samama, M | 1 |
| Majerus, PW | 1 |
| Alonso, D; Gay, WA; Pett, SB; Richter, RC; Stelzer, P; Subramanian, V; Tack-Goldman, K; Weksler, BB | 1 |
| Cauchie, C | 1 |
| Borda, ES; Gimeno, AL; Gimeno, MF; Lazzari, MA; Sterin-Borda, L | 1 |
| Viinikka, L; Ylikorkala, O | 1 |
| Fields, WS | 1 |
| Gustafson, A; Thorngren, M | 1 |
| Kauppila, A; Viinikka, L; Ylikorkala, O | 1 |
| Inoue, T | 1 |
| Fitzpatrick, JW; Freed, N; Giudice, JC; Papa, L | 1 |
| FitzGerald, GA; Oates, JA | 1 |
| Zoler, ML | 1 |
| Aguila, E; Lopez, L; Mehta, JL; Mehta, P; Ostrowski, N | 1 |
| Weksler, BB | 1 |
| Apprill, P; Ashton, J; Buja, LM; Bush, L; Campbell, WB; Firth, BG; Schmitz, J; Smitherman, T; Willerson, JT; Winniford, MD | 1 |
| Dworski, R; Musiał, J; Szczeklik, A | 1 |
| Nakamizo, N; Shuto, K; Yamada, K | 1 |
| Granström, E; Lundström, V; Swahn, ML | 1 |
| Mehta, J; Roberts, A | 1 |
| Catalano, PM; De Marco, L; Di Minno, G; Murphy, S; Shapiro, SS | 1 |
| Leid, RW; McConnell, LA | 1 |
| Ali, M; de Kergommeaux, BD; McDonald, JW | 1 |
| Lapetina, EG; Siess, W | 1 |
| Corell, T; Hasselmann, G; Splawinski, J; Wojtaszek, B | 1 |
| Anggård, E | 1 |
| Hatmi, M; Joseph, D; Rotilio, D; Vargaftig, BB | 1 |
| Agozzino, S; Bellavite, O; Donà, GC; Pagella, PG | 1 |
| Lewis, GP; Smith, JR | 1 |
| Finiasz, M; Gimeno, M; Lazzari, MA; Schattner, MA | 1 |
| Campbell, WB; Hillis, LD; Jackson, JA; Rehr, RB; Winniford, MD | 1 |
| Leĭtin, VL; Mazurov, AB; Repin, VS | 1 |
| Joist, JH; Stevens, DE; Sutera, SP | 1 |
| Salokannel, J; Viinikka, L; Ylikorkala, O | 1 |
| Bach, MK; Bothwell, WM; Creese, BR; Fitzpatrick, FA | 1 |
| Das, UN | 1 |
| Gryglewski, RJ | 1 |
| Benveniste, J; Chignard, M; Le Couedic, JP; Vargaftig, BB | 1 |
| Aharony, D; Pilo, R; Raz, A | 1 |
| Badenhorst, PN; Deckmyn, H; Vermylen, J | 1 |
| Crews, F; Horalek, C; Mehta, J; Mehta, P; Ostrowski, N; Roy, L | 1 |
| Held, E; Lorenz, R; Scherer, B; Siess, W; Weber, PC; Witzgall, H | 1 |
| Parker, CW; Stenson, WF | 1 |
| Kinlough-Rathbone, RL; Mustard, JF; Packham, MA | 1 |
| Benveniste, J; Chignard, M; Lefort, J; Vargaftig, BB | 1 |
| Araki, H; Lefer, AM; Smith, JB | 1 |
| French, AJ; Jackson, CA; Preston, FE; Stoddard, CJ; Whipps, S; Wyld, PJ | 1 |
| Buchanan, MR; Dejana, E; Gent, M; Hirsch, J; Mustard, JF | 1 |
| Chignard, M; Lefort, J; Marlas, G; Prado-Franceschi, J; Vargaftig, BB | 1 |
| Alexander, RW; Handin, RI | 1 |
| FitzGerald, GA; Friesinger, GC; Maas, RL; Oates, JA; Roberts, LJ; Robertson, D; Robertson, RM | 1 |
| Boyd, J; Eling, T; Korbut, R | 2 |
| Herman, AG | 1 |
| Kiistala, U; Oikarinen, A; Rytsälä, H; Viinikka, L; Ylikorkala, O | 1 |
| Abbate, R; Gensini, GF; Mannelli, M; Masotti, G; Poggesi, L; Serneri, GG | 1 |
| Mehta, JL | 1 |
| Frishman, WH | 2 |
| Chierchia, S; Crea, F; de Caterina, R; Maseri, A; Patrono, C | 1 |
| Breton-Gorius, J; Chignard, M; Conard, J; Dechavanne, M; Hotchen, M; Lagarde, M; Lecrubier, C; Samama, M; Vargaftig, B | 1 |
| Hwang, DH; LeBlanc, P | 1 |
| Ladd, N; Lewis, GP | 1 |
| Bessot, JC; Pauli, G; Vargaftig, BB | 1 |
| Berti, F; Folco, GC; Mandelli, V; Omini, C; Rossoni, G; Vigano, T | 1 |
| Becker, K; Brodde, OE; Giessler, C; Heinroth-Hoffmann, I; Pönicke, K | 1 |
| Imura, Y; Kiyota, Y; Nagai, Y; Nishikawa, K; Terashita, Z | 1 |
| Azevedo, I; Bachelet, M; de Blic, J; Scheinmann, P; Vargaftig, BB | 1 |
| Götze, O; Hespeling, U; Jungermann, K; Püschel, GP; Zwirner, J | 1 |
| Bass, T; Bove, AA; Deutsch, E; Goldberg, S; Macdonald, RG; Margolis, JR; Savage, MP; Taussig, A; Vetrovec, G; Whitworth, HB | 1 |
| Ichikawa, Y; Suzui, J; Suzuki, H; Watanabe, Y; Yoshida, K | 1 |
| Frölich, JC | 1 |
| Gréen, K; Henriksson, P; Rasmanis, G; Vesterqvist, O | 1 |
| Gomoll, AW; Ogletree, ML | 1 |
| Higo, K; Karasawa, A | 3 |
| Bertolet, BD; Pepine, CJ | 1 |
| Biagini, D; Cecioni, I; Colella, A; Costoli, A; Migliorini, A; Modesti, PA; Neri Serneri, GG | 1 |
| Antinori, A; Ciabattoni, G; De Candia, E; Landolfi, R; Masetti, R; Patrono, C; Rocca, B | 1 |
| Kurahashi, K; Nishimura, Y; Suzuki, A; Usui, H | 1 |
| Evans, RJ; Hayes, LJ; Heath, MF; Littler, RM; McEvoy, RJ; Poole, AW | 1 |
| Michalowski, AS | 1 |
| Li, ZY; Lian, EC; Yu, TF | 1 |
| Dabaghi, SF; Kamat, SG; Kleiman, NS; Marks, GF; Payne, J; Roberts, R; Schafer, AI | 1 |
| Higo, K; Karasawa, A; Shirakura, S; Takeda, M | 1 |
| Husted, SE; Vissinger, H; Winther, K | 1 |
| Lumley, P; Sullivan, AT; White, BP | 1 |
| Calza, R; Cattani, L; Ferri, A; Pellegrini, A | 1 |
| Castiglioni, C; Gazzaniga, PP; Parisi, S; Pignatelli, P; Pulcinelli, FM; Riondino, S | 1 |
| Higo, K; Karasawa, A; Kobayashi, T; Satoh, H | 1 |
| Anastasio, P; Borsatti, A; Calò, L; Cantaro, S; Capasso, G; Coppola, S; DeSanto, NG; Favaro, S | 1 |
| Egarter, C; Husslein, P; Karas, H | 1 |
| Beaufils, M; Uzan, S | 1 |
| oude Egbrink, MG; Reneman, RS; Slaaf, DW; Tangelder, GJ | 1 |
| Boddi, M; Gensini, GF; Gori, AM; Ieri, A; Margheri, M; Martini, F; Modesti, PA; Neri Serneri, GG; Poggesi, L; Rostagno, C | 1 |
| Hartikainen-Sorri, AL; Hiilesmaa, V; Lumme, R; Viinikka, L; Ylikorkala, O | 1 |
| Goldman, IS; Levine, L; Rigas, B | 1 |
| Arruzazabala, ML; Carbajal, D; Más, R; Molina, V; Valdés, S | 1 |
| Inazu, T; Maeda, H; Nakagawara, G; Taniguchi, T; Yamamura, H; Yang, C | 1 |
| Adams, KE; Brown, PA; Heys, SD; Whiting, PH | 1 |
| Roberts, MS; Seddon, RJ; Shen, J; Wanwimolruk, S; Wilson, PD | 1 |
| FitzGerald, GA; Meagher, EA | 1 |
| Ebbeling, L; Gerrard, JM; Gow, JA | 1 |
| Dekker, GA; Sibai, BM | 1 |
| Bachir, D; Foulon, I; Galacteros, F; Maclouf, J | 1 |
| Anastasio, P; Borsatti, A; Calò, L; Cantaro, S; Capasso, G; Coppola, S; De Santo, NG; Favaro, S | 1 |
| Becker, K; Bigl, H; Braquet, P; Förster, W; Lueddeckens, G; Sperling, J | 1 |
| Andreotti, F; Ciabattoni, G; Davies, G; Maseri, A; Patrono, C; Simonetti, BM; Sritara, P; Ujang, S | 1 |
| Ciabattoni, G; Rångemark, C; Wennmalm, A | 1 |
| Bode-Böger, SM; Böger, RH; Frölich, JC; Gutzki, FM; Tsikas, D; Weskott, HP | 1 |
| Landolfi, R; Patrignani, P; Patrono, C; Rocca, B | 1 |
| Adami, A; Benoni, G; Bonapace, S; Cuzzolin, L; Degan, M; Gaino, S; Lechi, C; Minuz, P; Tommasoli, R; Zuliani, V | 1 |
| Durham, SK; Megill, JR; Schumacher, WA; Steinbacher, TE | 1 |
| Akita, H; Chiba, H; Hui, SP; Jamieson, GA; Kobayashi, K; Matsuno, K; Nagasaka, H; Nakamura, H; Takahashi, Y; Tandon, NN | 1 |
| Bereczki, D; Bordánné, JE; Fekete, I; Misz, M; Oláh, L; Takács, EI | 1 |
| Evans, RJ; Jarvis, GE | 1 |
| Bonapace, S; Degan, M; Fontana, L; Gaino, S; Lechi, A; Lechi, C; Minuz, P; Tommasoli, R; Zuliani, V | 1 |
| Husted, SE; Kristensen, SD; Ravn, HB; Vissinger, H | 1 |
| Hart, HH; Norris, RM; White, HD; Williams, BF | 1 |
| Adami, A; Benoni, G; Bonapace, S; Crivellente, F; Cuzzolin, L; Degan, M; Minuz, P | 1 |
| Branch, DW; Martin, C; Mitchell, MD; Rodgers, G; Varner, MW | 1 |
| Cooper, J; Hardy, E; Heptinstall, S; Horn, EH; Rubin, PC | 1 |
| Imura, Y; Nishikawa, K; Terashita, Z | 1 |
| Dekker, GA | 1 |
| Hitsumoto, Y; Kodama, T; Okada, M; Sagawa, T; Tominaga, A | 1 |
| Andrioli, G; Bellavite, P; Benoni, G; Degan, M; Gaino, S; Lechi, A; Lechi, C; Minuz, P; Ortolani, R; Tommasoli, R; Zuliani, V | 1 |
| Landolfi, R; Patrono, C | 1 |
| Baenkler, HW; Bölcskei, PL; Lindenthal, U; Schäfer, D; Wagner, M | 1 |
| Audet, R; Burhop, KE; Drapeau, G; Marceau, F; Rioux, F | 1 |
| Farndale, RW; Heemskerk, JW; Sage, SO | 1 |
| Anges, C; Zou, M | 1 |
| Karanikas, G; Kritz, H; Sinzinger, H | 1 |
| Hiraishi, S; Horie, S; Ishii, H; Kazama, M; Kizaki, K; Kurusu, O; Nakahara, T; Noritake, S; Satoh, M; Yamada, M | 1 |
| Gullichsen, E; Kuttila, K; Mucha, I; Nelimarkka, O; Niinikoski, J; Rautanen, M; Riutta, A | 1 |
| Basili, S; Catalano, M; Ciabattoni, G; Davì, G; Giammarresi, C; Gresele, P; Nenci, GG; Patrono, C; Violi, F; Volpato, R | 1 |
| Ailus, K; Foudila, T; Marttunen, M; Palosuo, T; Söderstrom-Anttila, V; Tulppala, M; Ylikorkala, O | 1 |
| Bangerter, M; Griesshammer, M; Michiels, JJ; van Vliet, HH | 1 |
| Cipollone, F; Cuccurullo, F; Greco, A; Liuzzo, G; Maseri, A; Padovano, R; Panara, MR; Patrignani, P; Patrono, C; Quaranta, G; Rebuzzi, AG | 1 |
| Patrono, C; Renda, G | 1 |
| Hirai, A; Saitoh, Y; Shiina, T; Tamura, Y; Terano, T | 1 |
| Bronson, R; Martin, A; Meydani, M; Meydani, SN; Russell, RM; Smith, D; Stickel, F; Wu, D | 1 |
| Byrne, A; Crean, P; Fitzgerald, DJ; Maher, M; Moran, N; Walsh, N | 1 |
| Campbell, WB; Deinhart, DD; Pfister, SL | 1 |
| Nakayama, K; Shigenobu, K; Tanaka, Y | 1 |
| Ambroise-Thomas, P; Chumpitazi, BF; Peyron, F; Picot, S; Polack, B; Ricard, J; Simon, J | 1 |
| Barbui, T; Buchanan, MR; Cortelazzo, S; Falanga, A; Marchetti, M; Orlando, E | 1 |
| Fitzgerald, GA; Kinsella, T; Lawson, J; O'Mahony, D; Pratico, D | 1 |
| Aoki, T; Honda, S; Okubo, M; Seki, J; Senzaki, K; Takahashi, F; Takasugi, H; Tanaka, A; Tomiyama, Y | 1 |
| Berrettini, M; De Cunto, M; Nenci, GG; Orzalesi, G; Romanelli, A; Volpato, I | 1 |
| Dzúrik, R; Gajdos, M; Krivosiková, Z; Sebeková, K; Spustová, V | 1 |
| Konan, K; Nedogoda, VV; Spasov, AA | 1 |
| Hung, DY; Masci, PP; Mellick, GD; Roberts, MS; Whitaker, AN; Whitehouse, MW | 1 |
| Kääpä, P; Soukka, H; Viinikka, L | 1 |
| FitzGerald, GA; Habib, A; Maclouf, J | 1 |
| Frölich, JC; Ikic, M; Raida, M; Tewes, KS; Tsikas, D | 1 |
| Ala-Fossi, SL; Mäenpää, J; Riutta, A; Tuimala, R; Vainio, M; Ylitalo, P | 1 |
| Fitzgerald, D; Kearney, D | 1 |
| Bing, RJ; Cho, YK; Cohen, AM; Johnson, PE; Kakar, NR; Yamamoto, M; Yamamoto, T | 1 |
| Barry, OP; FitzGerald, GA; Ghiselli, A; Iuliano, L; Pasin, M; Praticó, D; Sabatino, G; Violi, F | 1 |
| Ciabattoni, G; Grobbee, DE; Kluft, C; Koudstaal, PJ; Patrono, C; van Kooten, F | 1 |
| Bellisola, G; Guidi, GC; Perona, G; Ricetti, MM; Rigo, A; Tecchio, C | 1 |
| Bing, RJ; Cohen, A; Kakar, R; Yamamoto, M; Yamamoto, T | 1 |
| Hishinuma, T; Matsumura, E; Mizugaki, M; Murai, Y; Tamai, M; Yamanobe, S; Yamazaki, T | 1 |
| Abe, F; Abe, K; Ito, S; Omata, K; Yamada, M | 1 |
| Dangelmaier, C; Daniel, JL; Jin, J; Kunapuli, SP; Smith, JB | 1 |
| Cayatte, AJ; Cohen, RA; Du, Y; Lavielle, G; Oliver-Krasinski, J; Verbeuren, TJ | 1 |
| Caughey, GE; Cleland, LG; Demasi, M; James, MJ; Penglis, PS | 1 |
| Hohlfeld, T; Liesener, S; Schanz, A; Schrör, K; Weber, AA | 1 |
| Camacho, M; Vila, L | 1 |
| Belton, O; Byrne, D; Fitzgerald, DJ; Kearney, D; Leahy, A | 1 |
| Bucciarelli, T; Ciabattoni, G; Cipollone, F; Cuccurullo, F; Davì, G; Di Gregorio, D; Pasquale, M; Patrignani, P; Patrono, C | 1 |
| Smulders, Y | 1 |
| Bing, RJ; Johnson, PE; Kakar, NR; Vina, ER; Yamamoto, T | 2 |
| Poullis, M | 1 |
| Cryer, B; Feldman, M; Shewmake, K | 1 |
| Andrioli, G; Bellavite, P; Lussignoli, S; Minuz, P; Ortolani, R; Pincelli, S; Solero, P | 1 |
| Cameron, KE; Heptinstall, S; May, JA; Sanderson, HM; Storey, RF; White, AE | 1 |
| Cyrus, T; FitzGerald, GA; Li, H; Praticò, D | 1 |
| Dewit, LG; Oussoren, YG; Stewart, FA; Te Poele, JA; van der Wal, A; van Kleef, EM | 1 |
| Bourassa, M; Brister, SJ; Buchanan, MR; Peniston, CM; Schwartz, L | 1 |
| Becker, BF; Heindl, B | 1 |
| Madan, ZM; Sainani, GS | 1 |
| Bing, RJ | 1 |
| Beckmann, I; Ben-Efraim, S; Vervoort, M; Wallenburg, HC | 1 |
| García Rodríguez, LA; Patrignani, P; Patrono, C | 1 |
| Caughey, GE; Cleland, LG; Gamble, JR; James, MJ; Penglis, PS | 1 |
| Gairard, A; Gaubert, E; Matz, RL; Van Overloop, B | 1 |
| Husted, SE; Jensen, HK; Kristensen, SD; Nielsen, HK; Vissinger, H; Ziegler, BK | 1 |
| Akiyama, K; Endoh, S; Kawagishi, Y; Kobayashi, M; Kudoh, M; Mita, H; Taniguchi, M | 1 |
| Gresele, P; Mezzasoma, AM; Venditti, G; Vezza, R | 1 |
| Halushka, MK; Halushka, PV | 1 |
| Hinek, A; Pace-Asciak, CR; Reynaud, D | 1 |
| Ballerio, R; Buccellati, C; Casagrande, C; Ciceri, P; Folco, G; Nicosia, S | 1 |
| Hamasaki, Y; Ishii, E; Zaitsu, M | 1 |
| Edenius, C; Ehnhage, A; Kölbeck, KG; Lindgren, JA; Tornhamre, S | 1 |
| Fang, YX; Li, J; Zhuang, HP | 1 |
| Fischer, MB; Gruber, R; Karreth, F; Schöfnagl, M; Watzek, G | 1 |
| Adnot, S; Belhassen, L; Dubois-Rande, JL; Pelle, G | 1 |
| Lund, T; Østerud, B | 1 |
| Li, J; Liu, LH; Zhuang, HP | 1 |
| Charman, SA; Charman, WN; Fitzgerald, GA; Frisbee, SE; Lockhart, EA; Monkhouse, DC; Weisman, S | 1 |
| Chen, CH; Qiu, LY; Yu, J; Zhou, Y | 1 |
| Chida, M; Hoshikawa, Y; Kondo, T; Kubo, H; Song, C; Suzuki, S; Tabata, T | 1 |
| Byrne, A; Cox, D; Crean, P; Fitzgerald, DJ; Kearney, D | 1 |
| Bose, R; McNicol, A; Roberts, DE | 1 |
| Andreotti, F; Ikonomidis, I; Nihoyannopoulos, P | 1 |
| Bolla, M; Habib, A; Henrion, D; Levy, BI; Levy-Toledano, S; Loufrani, L; You, D | 1 |
| Cazenave, JP; Eckly, A; Gachet, C; Lanza, F; Mangin, P; Ohlmann, P | 1 |
| Guth, BD; Narjes, H; Nehmiz, G; Riedel, A; Schubert, HD; Tanswell, P | 1 |
| Antman, EM; Wiviott, SD | 1 |
| Chlopicki, S; Janiszewski, M; Laurindo, FR; Miedzobrodzki, J; Olszanecki, R; Panz, T | 1 |
| del Soldato, P; Fiorucci, S; Lechi, A; Mencarelli, A; Meneguzzi, A; Minuz, P; Morelli, A; Renga, B | 1 |
| FitzGerald, GA; Hennekens, CH; Schror, K; Weisman, S | 1 |
| Coccheri, S; Marubini, E; Neri Serneri, GG; Violi, F | 1 |
| Koivisto, AM; Mäenpää, J; Riutta, A; Vainio, M | 1 |
| Hillbom, M; Juvela, S; Pyhtinen, J; Riutta, A; Saloheimo, P | 1 |
| Chen, XS; Cheng, Y; Fan, J; Fitzgerald, GA; Funk, CD; Klein-Szanto, A; Yu, Y | 1 |
| Atar, D; Kristensen, SR; Mickley, H; Svenstrup Poulsen, T | 1 |
| Chubb, A; Cox, D; Crean, P; Curtin, RJ; Dolan, C; Fitzgerald, DJ; Maree, AO; O'Brien, J; Shields, DC | 1 |
| Hsieh, PW; Wang, TW; Wang, WY; Wu, CC; Wu, YC | 1 |
| Baigent, C; García Rodríguez, LA; Landolfi, R; Patrono, C | 1 |
| de Leon-Casasola, OA; Kotob, F; Lema, MJ | 1 |
| Celestini, A; Di Renzo, L; Pignatelli, P; Pulcinelli, FM; Riondino, S; Trifirò, E; Violi, F | 1 |
| Chłopicki, S; Jawień, J; Korbut, R; Lomnicka, M | 1 |
| Bishop-Bailey, D; Mitchell, JA; Vojnovic, I; Warner, TD | 1 |
| Basili, S; Ciabattoni, G; Cipollone, F; Consoli, A; Davì, G; Devangelio, E; Falco, A; Mezzetti, A; Patrono, C; Santilli, F; Taraborelli, T | 1 |
| Musiał, J; Nizankowski, R; Sanak, M; Szczeklik, A; Undas, A | 1 |
| Pulcinelli, FM; Riondino, S | 1 |
| Capone, ML; D'Angelo, S; Di Francesco, L; Di Santo, A; Evangelista, V; Manarini, S; Patrignani, P; Ricciotti, E; Sacchetti, A; Scilimati, A; Sciulli, MG; Tacconelli, S | 1 |
| Buchanan, MR | 1 |
| Ferrer, JM; Lago, A; Pareja, A; Ponz, A; Santos, MT; Tembl, JI; Vallés, J | 1 |
| Barst, RJ; Christman, BW; Cunningham, G; Kawut, SM; Kimmel, SE; Lloyd, W; Loscalzo, J; Reilly, MP; Robbins, IM; Yung, D | 1 |
| Bellm, S; Cornelissen, J; Goddard, M; Kirtland, S; Large, S; Lim, E; Sheridan, K; Vuylsteke, A | 1 |
| Verbeuren, TJ | 1 |
| Aznar, J; Broekman, MJ; Cosin, J; Lago, A; Marcus, AJ; Moscardó, A; Piñón, M; Sanchez, E; Santos, MT; Vallés, J | 1 |
| Kranzhofer, R; Ruef, J | 1 |
| Pignatelli, P; Violi, F | 2 |
| Freedman, JE | 1 |
| Capone, ML; Evangelista, V; Manarini, S; Patrignani, P; Rebuzzi, A; Renda, G; Ricciotti, E; Sciulli, MG; Tacconelli, S | 1 |
| Cerletti, C; Dell'Elba, G; Evangelista, V; Manarini, S; Rotondo, S | 1 |
| Lip, GY; Shantsila, E; Watson, T | 1 |
| Aznar, J; Breña, S; Fuset, MP; Moscardo, A; Perez, F; Piñon, M; Ruano, M; Santos, MT; Valles, J | 1 |
| Dager, W; Ellison, J | 1 |
| Fitzgerald, DJ; Maree, AO | 1 |
| Alonso-Orgaz, S; Azcona, L; Bernardo, E; de Prada, TP; Fernández-Arquero, M; Fernández-Ortiz, A; López-Farré, AJ; Macaya, C; Mateos-Cáceres, PJ; Sacristán, D | 1 |
| Diodati, JG; Lordkipanidzé, M; Palisaitis, DA; Pharand, C; Schampaert, E; Turgeon, J | 1 |
| Cattaneo, M | 1 |
| Amore, C; Avanzini, F; Brero, L; de Berardis, G; de Simone, G; Dell'Elba, G; di Summa, P; Evangelista, V; Giorda, CB; Iacuitti, G; Levantesi, G; Maione, A; Manarini, S; Marelli, G; Nada, E; Nicolucci, A; Pecce, R; Pozzoli, G; Pupillo, M; Tognoni, G; Totani, L | 1 |
| Moonis, M; Patel, D | 1 |
| Barrabés, JA; Garcia-Dorado, D; Mirabet, M; Quiroga, A | 1 |
| Cosemans, JM; Eckes, B; Heemskerk, JW; Kuijpers, MJ; Munnix, IC; Nieswandt, B; Pozgajova, M | 1 |
| Avalos, I; Borntrager, H; Chung, CP; Milne, GL; Morrow, JD; Oeser, A; Raggi, P; Solus, J; Stein, CM | 1 |
| Censarek, P; Fleckenstein, D; Grosser, T; Hohlfeld, T; Paolini, C; Schrör, K; Steger, G; Weber, AA; Zimmermann, N | 1 |
| Cosin, J; Lago, A; Moscardo, A; Sánchez, E; Santos, MT; Tembl, J; Valles, J | 1 |
| Bailey, SR; Cunningham, FM; Elliott, J; Menzies-Gow, NJ; Sepulveda, MF | 1 |
| Biasucci, LM; Crea, F; Di Renzo, L; Gaudio, C; Mascioletti, S; Principessa, L; Pulcinelli, FM; Riondino, S; Trifirò, E | 1 |
| Grove, EL; Hvas, AM; Kristensen, SD; Mortensen, J; Nielsen, HL; Pedersen, SB; Thygesen, SS | 1 |
| Davì, G; De Cristofaro, R; Dragani, A; Falco, A; Fioritoni, F; Lattanzio, S; Lessiani, G; Mattoscio, D; Recchiuti, A; Rocca, B; Romano, M; Santilli, F | 1 |
| Dobaczewski, M; Durackova, Z; Golanski, J; Kazmierczak, P; Kostka, B; Lapshina, E; Markuszewski, L; Nocun, M; Ulicna, O; Watala, C; Zavodnik, I; Zavodnik, L | 1 |
| Barillà, F; Di Santo, S; Gaudio, C; Pignatelli, P; Violi, F | 1 |
| Ali, FY; Armstrong, PC; Bishop-Bailey, D; Dhanji, AA; Mitchell, JA; Paul-Clark, MJ; Truss, NJ; Tucker, AT; Vojnovic, I; Warner, TD; Zain, ZN | 1 |
| Barnard, MR; Fox, ML; Frelinger, AL; Li, Y; Linden, MD; Michelson, AD; Tarnow, I | 1 |
| Feher, A; Feher, G; Gasztonyi, B; Kotai, K; Lupkovics, G; Papp, E; Pusch, G; Szapary, L; Tibold, A | 1 |
| Biasucci, LM; Crea, F; Di Renzo, L; Ghirlanda, G; Giubilato, S; Leo, A; Liuzzo, G; Mattiello, T; Pitocco, D; Pulcinelli, FM; Riondino, S; Trifirò, E | 1 |
| Alberts, P; Bounameaux, H; Fontana, P; Mann, J; Sakariassen, KS; Sorensen, AS | 1 |
| Ciabattoni, G; Davì, G; Dragani, A; Ferrante, E; Habib, A; Lattanzio, S; Mattoscio, D; Mucci, L; Pascale, S; Patrono, C; Petrucci, G; Ranelletti, FO; Recchiuti, A; Rocca, B | 1 |
| Adachi, S; Akamatsu, S; Doi, T; Enomoto, Y; Iwama, T; Kozawa, O; Matsushima-Nishiwaki, R; Niwa, M; Ogura, S; Tokuda, H; Yoshimura, S | 1 |
| Fuset, MP; Moscardó, A; Ruano, M; Santos, MT; Valles, J | 2 |
| Si, XY; Zhao, YQ | 1 |
| Armstrong, PC; Dhanji, AR; Mitchell, JA; Tucker, AT; Warner, TD | 1 |
| Diodati, JG; Lordkipanidzé, M; Palisaitis, DA; Pharand, C; Schampaert, E | 1 |
| Aylward, PE; Behan, MW; Chew, DP | 1 |
| Ansara, AJ; Arif, SA; Koehler, JM; Nisly, SA; Nordmeyer, ST | 1 |
| d'Audiffret, AC; Frisbee, JC; Frisbee, SJ; Goodwill, AG; Stapleton, PA | 1 |
| Leśniak, M; Siudak, Z; Topór-Mądry, R; Tracz, W; Undas, A | 1 |
| Dawson, J; Rafferty, M; Walters, MR | 1 |
| Coimbra, LS; Gerlach, RF; Guimarães, MR; Herrera, BS; Muscará, MN; Rossa, C; Spolidorio, DM; Spolidorio, LC | 1 |
| Lordkipanidzé, M | 1 |
| Bal dit Sollier, C; Boval, B; Dillinger, JG; Drouet, L; Guyetand, C; Henry, P; Petroni, T; Sideris, G; Vermillet, A | 1 |
| Armstrong, PC; Chan, MV; Jakubowski, JA; Kirkby, NS; Leadbeater, PD; Mitchell, JA; Warner, TD | 1 |
| Chen, SX; Fan, XF; Wang, LX; Wang, MS; Zeng, HH | 1 |
| Nylander, S; Warner, TD; Whatling, C | 1 |
| Cherdon, C; de Leval, L; Defraigne, JO; Dogné, JM; Drion, P; Hanson, J; Masereel, B; Michiels, C; Ooms, A; Pirotte, B; Rolin, S; Sakalihassan, N | 1 |
| Anada, T; Asakura, H; Imanishi, K; Kusaka, A; Matsumoto, M; Miyamoto, K; Sai, Y; Sugama, J; Sugimoto, N; Takahashi, R | 1 |
| Battinelli, EM; Italiano, JE; Markens, BA | 1 |
| Dragani, A; Habib, A; Pagliaccia, F; Pascale, S; Patrono, C; Petrucci, G; Pocaterra, D; Ragazzoni, E; Rocca, B; Rolandi, G; Zaccardi, F | 1 |
| Tefferi, A | 1 |
| Biasucci, LM; Burzotta, F; Cataneo, L; Cosentino, N; Crea, F; Fracassi, F; Giubilato, S; Leo, A; Leone, AM; Narducci, ML; Niccoli, G; Porto, I; Pulcinelli, FM; Trani, C | 1 |
| De Caterina, R; Renda, G | 2 |
| Alusik, S; Bednar, F; Mottlova, J; Paluch, Z; Sadilkova, L | 1 |
| Azhar, KF; Haider, S; Miana, GA; Mushtaq, N; Naz, A; Nisa, M; Rasheed, H; Saify, ZS | 1 |
| Carlson, LM; Idborg, H; Jakobsson, PJ; Kogner, P; Rasmuson, A; Segerström, L; Sveinbjörnsson, B | 1 |
| Latorre, A; Madrid, I; Moscardó, A; Santos, MT; Vallés, J | 1 |
| Diamond, SL; Fries, S; Grosser, T; Li, R; Li, X | 1 |
| Campos-Estrada, C; Duaso, J; Ferreira, J; Galanti, N; Kemmerling, U; Lapier, M; López-Muñoz, R; Maya, JD; Molina-Berríos, A; Morello, A | 1 |
| Lago, A; Moscardo, A; Parkhutik, V; Santos, MT; Tembl, J; Valles, J | 1 |
| Bonastre, J; Latorre, AM; Madrid, I; Moscardo, A; Ruano, M; Santos, MT; Valles, J | 1 |
| Blaha, CA; Drew, RC; Herr, MD; Mast, JL; Muller, MD; Sinoway, LI; Stocker, SD | 1 |
| Andrikopoulou, E; Blumenthal, RS; DeFilippis, AP; Fasoro, YA; Gerstenblith, G; Guallar, E; Jaffe, AS; Kickler, TS; Oloyede, OS; Palachuvattil, JM; Rade, JJ; Saenger, AK; Schulman, SP | 1 |
| Ferro, A; Floyd, CN | 1 |
| Alberti, S; Dovizio, M; Guillem-Llobat, P; Patrignani, P | 1 |
| Golanski, J; Rozalski, M; Watala, C | 1 |
| Bolli, R; Cambon, A; DeFilippis, AP; Jaffe, AS; Jones, RO; Miles, RJ; Moser, AB; Rai, SN; Schulman, SP | 1 |
| Adam, I; Ashur, BM; Elbareg, AM; Elmahashi, MO; Essadi, FM | 1 |
| Barbieri, SS; Cavalca, V; Dragani, A; Pagliaccia, F; Patrono, C; Porro, B; Rocca, B; Squellerio, I; Tremoli, E; Veglia, F | 1 |
| Fan, J; Li, J; Yu, G | 1 |
| Davì, G; La Barba, S; Lapenna, D; Santilli, F | 1 |
| Boyce, JA; Feng, C; Garofalo, D; Katz, H; Lai, J; Laidlaw, TM; Liu, T | 1 |
| Blair, TA; Hers, I; Moore, SF | 1 |
| Boyce, JA; Laidlaw, TM | 1 |
| Davì, G; Pignatelli, P; Santilli, F; Violi, F | 1 |
| Cavalca, V; Ciaffardini, F; Ciminello, A; Habib, A; Pagliaccia, F; Patrono, C; Petrucci, G; Pitocco, D; Rizzi, A; Rizzo, P; Rocca, B; Squellerio, I; Tanese, L; Tremoli, E; Zaccardi, F | 1 |
| Kimple, ME; Wisinski, JA | 1 |
| Hsu, MT; Huang, SW; Huang, TF; Kuo, HL; Kuo, SC; Lien, JC; Lin, SW; Peng, HC; Tseng, YJ | 1 |
| Kong, XJ; Li, JY; Liu, XW; Ma, N; Mohamed, I; Shen, DS; Yang, YJ; Zhao, XL | 1 |
| Kucheryavenko, AF; Spasov, AA; Suzdalev, KF; Tian, M | 1 |
| Cox, D; Fitzgerald, DJ | 1 |
| Al-Asady, N; Caro, J; Clavijo, LC; Dhillon, A; Matthews, RV; Rowe, V; Shavelle, DM; Tun, H | 1 |
| Caulfield, M; Fitzgerald, DJ; Ho, E; Howard, P; Hughes, AD; Johnson, T; McCarthy, NS; Munroe, PB; O'Brien, E; Rooney, C; Sever, P; Shields, DC; Stanton, AV; Surendran, P; Thom, S; Treumann, A; Vangjeli, C | 1 |
| Canino, J; Canobbio, I; Guidetti, GF; Torti, M; Visconte, C; Zarà, M | 1 |
| Chen, J; Chen, W; Li, H; Mao, J; Wang, M; Wang, W; Zhang, H | 1 |
| Huang, R; Ye, W; Zhang, J; Zhu, J | 1 |
| Huang, MZ; Jiao, ZH; Kong, XJ; Li, JY; Li, SH; Liu, XW; Ma, N; Qin, Z; Shen, DS; Yang, YJ | 1 |
| Feghhi, S; John, AS; Karchin, A; Lim, E; Rue, T; Smith, AO; Sniadecki, NJ; Taparia, N; Ting, LH; Wang, X; White, NJ | 1 |
| Allen, PD; Armstrong, PC; Cerutti, C; Gil-Bernabé, AM; Gomes, AL; Lucotti, S; Markelc, B; Mitchell, JA; Muschel, RJ; Ridley, AJ; Smart, S; Soyer, M; Warner, TD; Watson, K | 1 |
| Jiao, Z; Kong, X; Li, J; Li, S; Liu, X; Ma, N; Qin, Z; Shen, D; Yang, Y | 1 |
| Li, RHL; Nguyen, N; Tablin, F | 1 |
| Bai, R; Bode, AM; Chang, X; Dong, Z; Falk, GW; Foster, NR; Iyer, PG; Johnson, ML; Limburg, PJ; Ma, WY; Wang, K; Wang, Q; Zhang, T | 1 |
| El Kadiry, AEH; Kojok, K; Merhi, Y; Mohsen, M; Mourad, W | 1 |
| Allan, HE; BioResource, N; Chan, MV; Crescente, M; Dong, L; Downes, K; Edin, ML; Freson, K; Greene, D; Hanif, M; Hart, DP; Hayman, MA; Laffan, MA; Lentaigne, C; Malkowski, MG; Milne, GL; O'Donnell, VB; Ouwehand, WH; Sivapalaratnam, S; Stephens, J; Stubbs, M; Turro, E; Warner, TD; Wedderburn, K; Zeldin, DC | 1 |
| Amadio, P; Barbieri, S; Barbieri, SS; Cavalca, V; Cosentino, N; Di Minno, A; Eligini, S; Fiorelli, S; Giuliani, M; Gorini, A; Olivares, P; Porro, B; Trabattoni, D; Tremoli, E; Veglia, F; Werba, JP | 1 |
| Fan, X; Liu, J; Ma, X; Wei, M; Wu, X; Xue, M; Zhang, H | 1 |
| Ballerini, P; Bruno, A; Chakraborty, R; Contursi, A; D'Agostino, I; Dovizio, M; Falcone, L; Hu, X; Hwa, J; Jain, K; Landolfi, R; Mucci, L; Patrignani, P; Sacco, A; Tacconelli, S; Xie, Y; Zucchelli, M | 1 |
| Ambs, S; Baker, F; Cook, MB; Dorsey, TH; Kiely, M; Loffredo, CA; Milne, GL; Minas, TZ; Smith, CJ; Tang, W; Yates, C | 1 |
| Böhnlein, H; Eichler, S; Göbel, K; Huntemann, N; Kehrel, BE; Loser, K; Masanneck, L; Meuth, SG; Nieswandt, B; Schüngel, L; Vogelsang, A; Willison, A; Zarbock, A | 1 |
| Abdelazeem, H; Aljesri, K; Norel, X; Ozen, G; Topal, G; Turkyılmaz, G; Turkyılmaz, S | 1 |
| Chen, W; Dong, Z; Li, H; Xu, R; Yan, Y; Zhang, H; Zheng, X | 1 |
| Abadi, SSD; Abdi, M; Lamardi, ZH; Massoudi, N; Mohammadi, L; Nasiri, MJ; Shirjan, F; Zangiabadian, M | 1 |
| Honma, M; Kariya, Y; Konagaya, A; Suzuki, H; Tokuda, K | 1 |
| Chen, W; Dai, Y; Li, H; Wu, G; Xu, R; Yin, Z; Zhang, H | 1 |
| Perry, RJ | 1 |
| Ballerini, P; Bruno, A; Contursi, A; Patrignani, P; Tacconelli, S | 1 |
89 review(s) available for aspirin and thromboxane a2
| Article | Year |
|---|---|
The role of prostaglandins in platelet function.
Topics: Acetylation; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Aspirin; Blood Platelets; Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Epoprostenol; Hemostasis; Humans; Peroxides; Phospholipases; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Thromboxane A2; Thromboxanes | 1979 |
The role of prostacyclin in vascular tissue.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Coagulation; Blood Platelets; Blood Vessels; Cyclic AMP; Dipyridamole; Epoprostenol; Linolenic Acids; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Thrombosis; Thromboxane A2; Vasodilation | 1979 |
The role of prostaglandins in platelet function.
Topics: Animals; Arteriosclerosis; Aspirin; Bleeding Time; Blood Platelets; Chemical Phenomena; Chemistry; Cyclic AMP; Epoprostenol; Haplorhini; Humans; Male; Platelet Aggregation; Prostaglandins; Thromboxane A2; Thromboxane B2; Thromboxanes | 1979 |
Proposed metabolic dysfunctions in diabetic microthromboses and microangiopathy.
Topics: Alprostadil; Aspirin; Blood Platelets; Calcimycin; Collagen; Cyclic AMP; Cyclic GMP; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Dinoprost; Dinoprostone; Humans; Indomethacin; Models, Biological; Platelet Aggregation; Prostaglandins; Prostaglandins E; Prostaglandins F; Thromboxane A2 | 1979 |
[Aspirin in the prevention of thromboembolic diseases].
Topics: Animals; Aspirin; Clinical Trials as Topic; Depression, Chemical; Epoprostenol; Humans; Platelet Aggregation; Rats; Thromboembolism; Thromboxane A2 | 1978 |
Strokes, transient ischemic attacks and asymptomatic bruits.
Topics: Aged; Anticoagulants; Aspirin; Auscultation; Blood Platelets; Blood Pressure; Carotid Arteries; Cerebrovascular Disorders; Endarterectomy; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Ophthalmic Artery; Pulse; Risk; Thromboxane A2; Ultrasonography | 1979 |
[Acetylsalicyl acid (ASA) and prostaglandins].
Topics: Arthritis, Rheumatoid; Aspirin; Asthma; Chemical Phenomena; Chemistry; Collagen; Drug Interactions; Female; Humans; Male; Platelet Aggregation; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Thromboxane A2; Uterine Contraction | 1977 |
[Clinical pharmacology of acetylsalicylic acid].
Topics: Administration, Oral; Animals; Aspirin; Biological Availability; Coronary Artery Bypass; Dose-Response Relationship, Drug; Graft Occlusion, Vascular; Humans; Myocardial Infarction; Platelet Aggregation; Thromboxane A2 | 1992 |
[Prostaglandins and ischemic cardiopathy].
Topics: Angina, Unstable; Aspirin; Coronary Thrombosis; Humans; Myocardial Ischemia; Platelet Activation; Prostaglandins; Thrombolytic Therapy; Thromboxane A2 | 1992 |
Antiplatelet and anticoagulant drugs in coronary vascular disease.
Topics: Animals; Anticoagulants; Aspirin; Blood Platelets; Coronary Thrombosis; Humans; Platelet Aggregation Inhibitors; Thromboxane A2 | 1992 |
Principles and applications of manipulation of prostaglandin synthesis in pregnancy.
Topics: Aspirin; Diet; Dietary Fats; Epoprostenol; Fatty Acids, Unsaturated; Female; Humans; Indomethacin; Platelet Aggregation; Pregnancy; Pregnancy Complications; Prostaglandins; Thromboxane A2 | 1992 |
[Aspirin as a cyclooxygenase inhibitor in various complications of the gestational period].
Topics: Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Epoprostenol; Female; Fetal Growth Retardation; Humans; Placenta; Placental Insufficiency; Pre-Eclampsia; Pregnancy; Prostaglandin-Endoperoxide Synthases; Thromboxane A2 | 1992 |
Activation of thromboxane and prostacyclin biosynthesis in humans.
Topics: Aspirin; Epoprostenol; Humans; Myocardial Infarction; Reference Values; Thromboxane A2 | 1991 |
Effects of non-steroidal anti-inflammatory drugs on the in vivo synthesis of thromboxane and prostacyclin in humans.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Depression, Chemical; Epoprostenol; Humans; Piroxicam; Thromboxane A2; Time Factors | 1991 |
[Therapy of arterial occlusive disease].
Topics: Arterial Occlusive Diseases; Aspirin; Fish Oils; Humans; Platelet Aggregation Inhibitors; Prostaglandin Antagonists; Thromboxane A2 | 1990 |
Pathophysiological role of thromboxane A2 and pharmacological approaches to its inhibition.
Topics: Angina, Unstable; Animals; Aspirin; Humans; Myocardial Infarction; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2; Thromboxane-A Synthase | 1990 |
[Pharmacological correction of disorders of the prostacyclin- thromboxane balance in ischemic heart disease: problems and prospects].
Topics: Aspirin; Coronary Disease; Epoprostenol; Humans; Thrombosis; Thromboxane A2; Thromboxane-A Synthase | 1990 |
Platelets as a source of vasoactive mediators.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Endothelium, Vascular; Humans; Prostaglandins; Serotonin; Thromboxane A2; Vasomotor System | 1990 |
Biosynthesis and pharmacological modulation of thromboxane in humans.
Topics: Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Humans; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2; Thromboxane-A Synthase | 1990 |
Aspirin as an antithrombotic drug: from the aggregometer to clinical trials.
Topics: Aspirin; Cerebrovascular Disorders; Humans; Meta-Analysis as Topic; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Antagonists; Randomized Controlled Trials as Topic; Thrombosis; Thromboxane A2 | 1990 |
Current concepts for a drug-induced inhibition of formation and action of thromboxane A2.
Topics: Aspirin; Humans; Thromboxane A2 | 1990 |
Acetylsalicylic acid and the balance between prostacyclin and thromboxane A2.
Topics: Arteriosclerosis; Aspirin; Clinical Trials as Topic; Drug Administration Schedule; Epoprostenol; Female; Humans; Pre-Eclampsia; Pregnancy; Thromboxane A2 | 1990 |
Thromboxane biosynthesis in cardiovascular diseases.
Topics: Aspirin; Cardiovascular Diseases; Humans; Platelet Activation; Risk Factors; Thromboxane A2; Thromboxane B2 | 1990 |
Pathological significance of the thromboxane-prostacyclin hypothesis.
Topics: Animals; Arteriosclerosis; Aspirin; Blood Platelets; Blood Vessels; Epoprostenol; Humans; Prostaglandins, Synthetic; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes; Vascular Diseases | 1985 |
Aspirin and other platelet active drugs. Relationship among dose, effectiveness, and side effects.
Topics: Aspirin; Blood Platelets; Dipyridamole; Epoprostenol; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Stomach Diseases; Thromboxane A2 | 1989 |
Bleeding in renal failure.
Topics: Anemia; Aspirin; Bleeding Time; Blood Platelets; Blood Transfusion; Cryoprotective Agents; Deamino Arginine Vasopressin; Erythrocyte Transfusion; Erythropoietin; Estrogens; Hemorrhage; Humans; Parathyroid Hormone; Platelet Adhesiveness; Platelet Aggregation; Thromboxane A2; Uremia; von Willebrand Factor | 1988 |
Measurements of the in vivo synthesis of thromboxane and prostacyclin in humans.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Vessel Prosthesis; Epoprostenol; Heart, Artificial; Humans; Myocardial Infarction; Thromboxane A2 | 1988 |
Is there an optimal dose and formulation of aspirin to prevent arterial thrombo-embolism in man?
Topics: Aspirin; Blood Platelets; Blood Vessels; Chemistry, Pharmaceutical; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Epoprostenol; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation; Pregnancy; Thromboembolism; Thromboxane A2 | 1986 |
[New theories on the pathogenesis and methods of treating thrombotic thrombocytopenic purpura (Moschkowitz disease)].
Topics: Adolescent; Adult; Aspirin; Blood Coagulation Disorders; Child; Dipyridamole; Epoprostenol; Female; Humans; Immunologic Deficiency Syndromes; Male; Plasmapheresis; Purpura, Thrombotic Thrombocytopenic; Thromboxane A2 | 1986 |
Prostacyclin, from discovery to clinical application.
Topics: Animals; Arteriosclerosis; Aspirin; Cell Survival; Disease; Epoprostenol; Extracorporeal Circulation; Freezing; Humans; Thromboxane A2; Thromboxane-A Synthase | 1985 |
Insulin and arachidonic acid metabolism in diabetes mellitus.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arthritis, Rheumatoid; Aspirin; Blood Platelets; Diabetes Mellitus; Epoprostenol; Humans; Insulin; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1985 |
Clinical aspects of the arachidonic acid--thromboxane pathway.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Coagulation; Cerebrovascular Disorders; Epoprostenol; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation; Receptors, Prostaglandin; Receptors, Thromboxane; Thrombosis; Thromboxane A2; Thromboxane-A Synthase | 1983 |
[Pharmacology of anti-platelet agents].
Topics: Animals; Anticoagulants; Aspirin; Blood Platelets; Cyclic AMP; Cyclooxygenase Inhibitors; Dipyridamole; Epoprostenol; Female; Fibrinolytic Agents; Humans; In Vitro Techniques; Intestinal Absorption; Kinetics; Male; Papio; Platelet Aggregation; Prostaglandin Antagonists; Rabbits; Sulfinpyrazone; Thiophenes; Thrombosis; Thromboxane A2; Ticlopidine | 1983 |
Arachidonate metabolism in vascular disorders.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Blood Vessels; Cyclic AMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium; Epoprostenol; Fatty Acids, Unsaturated; Fibrinolytic Agents; Humans; Thromboxane A2; Thromboxane-A Synthase; Vascular Diseases | 1983 |
Aspirin for prevention of stroke: a review.
Topics: Aspirin; Cell Adhesion; Cerebrovascular Disorders; Humans; Ischemic Attack, Transient; Platelet Aggregation; Prostaglandins; Thrombosis; Thromboxane A2 | 1983 |
Effects of acetylsalicylic acid and dietary intervention on primary hemostasis.
Topics: Animals; Aspirin; Blood Coagulation; Dietary Fats; Dose-Response Relationship, Drug; Epoprostenol; Fatty Acids, Unsaturated; Fishes; Hemostasis; Humans; Thromboxane A2 | 1983 |
Eicosanoids and venous thromboembolism.
Topics: Animals; Arachidonic Acids; Aspirin; Dipyridamole; Dogs; Epoprostenol; Hemostasis; Humans; Platelet Adhesiveness; Platelet Aggregation; Pulmonary Embolism; Thromboembolism; Thrombophlebitis; Thromboxane A2 | 1983 |
[Blood platelets and myocardial infarction].
Topics: Aspirin; Blood Platelets; Dipyridamole; Epoprostenol; Humans; Myocardial Infarction; Platelet Aggregation; Prostaglandins, Synthetic; Sulfinpyrazone; Thromboxane A2 | 1984 |
The possible roles of prostaglandins and related compounds in endometrial bleeding. A mini-review.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Endometrium; Endothelium; Epoprostenol; Female; Fibrin; Hemostasis; Humans; Intrauterine Devices; Menstruation; Prostaglandin Endoperoxides; Prostaglandins; Thromboxane A2; Uterine Hemorrhage; Uterus | 1983 |
The role of phospholipase C in platelet responses.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Diglycerides; Enzyme Activation; Humans; Phosphatidic Acids; Phospholipases; Phospholipases A; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thrombin; Thromboxane A2; Type C Phospholipases | 1983 |
Atherosclerosis and prostaglandins.
Topics: Alprostadil; Arteriosclerosis; Aspirin; Blood Vessels; Cell Membrane Permeability; Cell Survival; Cholesterol; Endothelium; Epoprostenol; Humans; Platelet Adhesiveness; Prostaglandins; Prostaglandins E; Thromboxane A2 | 1982 |
Prostaglandins, platelets, and atherosclerosis.
Topics: Animals; Arachidonic Acids; Arteriosclerosis; Aspirin; Blood Circulation; Blood Vessels; Carotid Artery Thrombosis; Cyclooxygenase Inhibitors; Dogs; Epoprostenol; Female; Humans; Infusions, Parenteral; Male; Mice; Myocardial Infarction; Platelet Aggregation; Prostaglandins; Rabbits; Rats; Structure-Activity Relationship; Thromboembolism; Thromboxane A2; Thromboxanes | 1980 |
Prostaglandins, macrophages, and immunity.
Topics: Arachidonic Acids; Aspirin; Cell Division; Cell Separation; Epoprostenol; Immunity, Cellular; Indomethacin; Inflammation; Lymphocytes; Lymphokines; Macrophages; Prostaglandins; Prostaglandins E; Thromboxane A2 | 1980 |
Prostaglandins and platelets.
Topics: Arachidonic Acids; Aspirin; Blood Platelets; Epoprostenol; Fatty Acids; Humans; Oxygenases; Phospholipases A; Phospholipases A1; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins; Sulfinpyrazone; Thrombosis; Thromboxane A2 | 1980 |
Thromboxane A2, prostacyclin and aspirin: effects on vascular tone and platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Vessels; Cats; Coronary Vessels; Epoprostenol; Guinea Pigs; Humans; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandins; Prostaglandins E; Prostaglandins F; Rabbits; Thromboxane A2; Thromboxanes | 1980 |
The role of prostacyclin and thromboxane A2 in the regulation of platelet behaviour.
Topics: Aspirin; Dipyridamole; Epoprostenol; Hemorrhage; Humans; Platelet Aggregation; Prostaglandins; Thrombosis; Thromboxane A2; Thromboxanes | 1980 |
Prostacyclin and the vascular endothelium.
Topics: Animals; Aspirin; Blood Pressure; Depression, Chemical; Dogs; Epoprostenol; Guinea Pigs; Humans; Kidney; Platelet Aggregation; Prostaglandin Antagonists; Prostaglandins; Rabbits; Rats; Thromboxane A2; Vascular Resistance; Vasodilator Agents | 1981 |
Eighth Gaddum Memorial Lecture. University of London Institute of Education, December 1980. Biological importance of prostacyclin.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Platelets; Blood Vessels; Cattle; Epoprostenol; Fibrinolytic Agents; Hemostasis; History of Medicine; Humans; Pharmacology; Prostaglandins; Thromboxane A2; Thromboxane-A Synthase | 1982 |
Antiplatelet therapy in coronary heart disease.
Topics: Adenosine Diphosphate; Adult; Aged; Angina Pectoris; Aspirin; Blood Platelets; Cerebrovascular Disorders; Coronary Disease; Epinephrine; Epoprostenol; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Adhesiveness; Platelet Aggregation; Propranolol; Thromboxane A2 | 1982 |
Daily life cardiac ischaemia. Should it be treated?
Topics: Activities of Daily Living; Adrenergic beta-Antagonists; Aspirin; Calcium Channel Blockers; Drug Therapy, Combination; Humans; Myocardial Ischemia; Myocardial Revascularization; Nitrates; Outcome Assessment, Health Care; Risk Factors; Thromboxane A2 | 1995 |
Low dose acetylsalicylic acid in the antithrombotic treatment of patients with stable angina pectoris and acute coronary syndromes (unstable angina pectoris and acute myocardial infarction).
Topics: Administration, Oral; Angina Pectoris; Antithrombins; Aspirin; Humans; Injections, Intravenous; Male; Myocardial Infarction; Thromboxane A2 | 1994 |
[Acetylsalicylic acid in pregnancy].
Topics: Aspirin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Epoprostenol; Female; Fetal Growth Retardation; Humans; Infant, Newborn; Obstetric Labor, Premature; Pre-Eclampsia; Pregnancy; Thromboxane A2 | 1993 |
[Pregnancy nephropathies].
Topics: Adult; Antihypertensive Agents; Aspirin; Epoprostenol; Female; Hemostasis; Humans; Hypertension; Kidney Diseases; Placental Insufficiency; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Thromboxane A2 | 1993 |
Disordered eicosanoid formation in pregnancy-induced hypertension.
Topics: Aspirin; Eicosanoids; Epoprostenol; Female; Humans; Hypertension; Pregnancy; Pregnancy Complications, Cardiovascular; Thromboxane A2 | 1993 |
Low-dose aspirin in the prevention of preeclampsia and fetal growth retardation: rationale, mechanisms, and clinical trials.
Topics: Angiotensin II; Aspirin; Clinical Trials as Topic; Epoprostenol; Female; Fetal Growth Retardation; Humans; Platelet Aggregation Inhibitors; Pre-Eclampsia; Pregnancy; Thromboxane A2 | 1993 |
Characterization of biochemical and functional effects of antiplatelet drugs as a key to their clinical development.
Topics: Aspirin; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; Cyclooxygenase Inhibitors; Drug Design; Enzyme Inhibitors; Humans; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 1995 |
The pharmacological prevention of pre-eclampsia.
Topics: Aspirin; Epoprostenol; Female; Humans; Platelet Aggregation Inhibitors; Pre-Eclampsia; Pregnancy; Randomized Controlled Trials as Topic; Thromboxane A2 | 1995 |
Aspirin in polycythemia vera and essential thrombocythemia: current facts and perspectives.
Topics: Adult; Aged; Aspirin; Cyclooxygenase Inhibitors; Erythromelalgia; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Polycythemia Vera; Thrombocythemia, Essential; Thromboxane A2 | 1996 |
Aspirin in essential thrombocythemia: status quo and quo vadis.
Topics: Abortion, Habitual; Aspirin; Cerebrovascular Disorders; Cohort Studies; Contraindications; Erythromelalgia; Female; Fibrinolytic Agents; Forecasting; Hemorrhage; Humans; Incidence; Middle Aged; Myeloproliferative Disorders; Pilot Projects; Platelet Activation; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy Complications, Hematologic; Retrospective Studies; Safety; Thrombocythemia, Essential; Thrombophilia; Thrombosis; Thromboxane A2; Vision Disorders; von Willebrand Diseases | 1997 |
Platelet activation and inhibition in unstable coronary syndromes.
Topics: Angina, Unstable; Aspirin; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Thromboxane A2; Ticlopidine | 1997 |
Mechanism of anti-proliferative action of eicosapentaenoic acid (EPA) in vascular cell growth: its effect on signal transduction system.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arteriosclerosis; Arteriosclerosis Obliterans; Aspirin; Cell Division; Cells, Cultured; Clinical Trials as Topic; Eicosanoids; Eicosapentaenoic Acid; Epoprostenol; Fibrinolytic Agents; Growth Inhibitors; Hemostasis; Humans; Hypolipidemic Agents; Muscle, Smooth, Vascular; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Signal Transduction; Thrombophilia; Thrombosis; Thromboxane A2 | 1997 |
The anti-thrombotic effects of statins.
Topics: Aspirin; Blood Coagulation Factors; Cholesterol, HDL; Cholesterol, LDL; Coronary Thrombosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thromboxane A2; Treatment Outcome | 1999 |
New look at myocardial infarction: toward a better aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Drug Combinations; Drug Design; Epoprostenol; Humans; Macrophages; Myocardial Infarction; Myocardium; Nitric Oxide; Thromboxane A2 | 1999 |
Myocardial ischemia and infarction: growth of ideas.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; Cyclooxygenase Inhibitors; Endothelial Growth Factors; Epoprostenol; Gene Transfer Techniques; Genetic Therapy; Humans; Lymphokines; Myocardial Infarction; Myocardial Ischemia; Myocardium; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Blood Platelets; Cardiovascular Diseases; Celecoxib; Colorectal Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Depression, Chemical; Dinoprostone; Epoprostenol; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Incidence; Intestinal Mucosa; Isoenzymes; Lactones; Membrane Proteins; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Randomized Controlled Trials as Topic; Substrate Specificity; Sulfonamides; Sulfones; Thromboembolism; Thromboxane A2; Treatment Outcome | 2001 |
Aspirin resistance: definition, mechanisms and clinical read-outs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Clinical Trials as Topic; Drug Interactions; Drug Resistance; Humans; Models, Biological; Risk; Thrombosis; Thromboxane A2; Thromboxane B2; Time Factors | 2003 |
Terms and conditions: semantic complexity and aspirin resistance.
Topics: Aspirin; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Cyclooxygenase Inhibitors; Drug Interactions; Drug Resistance; Follow-Up Studies; Genetic Variation; Humans; Patient Compliance; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk; Thromboxane A2; Thromboxane B2; Treatment Failure | 2004 |
A critical appraisal of the phenomenon of aspirin resistance.
Topics: Aspirin; Atherosclerosis; Cardiovascular Diseases; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Thromboxane A2; Thromboxane B2 | 2005 |
Low-dose aspirin for the prevention of atherothrombosis.
Topics: Arteriosclerosis; Aspirin; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Interactions; Drug Resistance; Gastrointestinal Hemorrhage; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk; Stroke; Thrombosis; Thromboxane A2 | 2005 |
Aspirin resistance.
Topics: Aspirin; Cardiovascular Diseases; Drug Resistance; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Risk Factors; Thromboxane A2; Treatment Outcome | 2005 |
[Terutroban and endothelial TP receptors in atherogenesis].
Topics: Animals; Apolipoproteins E; Aspirin; Atherosclerosis; Cell Adhesion; Cell Adhesion Molecules; Cholesterol; Clinical Trials as Topic; Dogs; Drug Evaluation, Preclinical; Endothelium, Vascular; Fibrinolytic Agents; Foam Cells; Guinea Pigs; Humans; Macrophages; Mice; Mice, Knockout; Models, Biological; Monocytes; Naphthalenes; Platelet Aggregation Inhibitors; Propionates; Receptors, Thromboxane A2, Prostaglandin H2; Swine; Thromboxane A2 | 2006 |
Aspirin resistance: is this term meaningful?
Topics: Aspirin; Blood Platelets; Cyclooxygenase 1; Drug Resistance; Humans; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2 | 2006 |
Aspirin resistance: what, why and when?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cardiovascular Diseases; Drug Resistance; Humans; Platelet Aggregation; Thromboxane A2 | 2007 |
Variable platelet response to aspirin and clopidogrel in atherothrombotic disease.
Topics: Adenosine Diphosphate; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Biomarkers; Biotransformation; Blood Coagulation Tests; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Interactions; Drug Resistance; Hemorrhage; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thrombosis; Thromboxane A2; Thromboxane B2; Ticlopidine; Treatment Failure | 2007 |
Clinical implications of aspirin resistance.
Topics: Aspirin; Cyclooxygenase 1; Drug Resistance; Enzyme Inhibitors; Heart Diseases; Humans; Ischemia; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Thromboxane A2 | 2007 |
Aspirin resistance: focus on clinical endpoints.
Topics: Aspirin; Bleeding Time; Cardiovascular Diseases; Drug Resistance; Evidence-Based Medicine; Humans; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Reproducibility of Results; Terminology as Topic; Thromboxane A2; Treatment Outcome | 2008 |
Effect of pharmaceutical interventions targeting thromboxane receptors and thromboxane synthase in cardiovascular and renal diseases.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Humans; Kidney Diseases; Platelet Aggregation Inhibitors; Proteinuria; Receptors, Thrombin; Thrombosis; Thromboxane A2; Thromboxane-A Synthase; Ticlopidine | 2009 |
[Research advances in aspirin resistance].
Topics: Aspirin; Drug Resistance; Humans; Thromboxane A2 | 2009 |
The role of antiplatelet therapy in the secondary prevention of coronary artery disease.
Topics: Adenosine; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Secondary Prevention; Thiophenes; Thromboxane A2; Ticagrelor; Ticlopidine | 2010 |
Aspirin dosing for the prevention and treatment of ischemic stroke: an indication-specific review of the literature.
Topics: Aspirin; Atherosclerosis; Carotid Artery Diseases; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Ischemia; Myocardial Infarction; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Stroke; Thromboxane A2 | 2010 |
Anti-platelet therapy and aspirin resistance - clinically and chemically relevant?
Topics: Aspirin; Blood Platelets; Clinical Medicine; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Thromboxane A2 | 2010 |
Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy.
Topics: Aspirin; Blood Platelets; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins; Purinergic P2Y Receptor Antagonists; Thrombosis; Thromboxane A2 | 2011 |
Clinical use of aspirin in ischemic heart disease: past, present and future.
Topics: Animals; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Hemorrhage; History, 20th Century; History, 21st Century; Humans; Myocardial Ischemia; Patient Selection; Platelet Aggregation Inhibitors; Primary Prevention; Risk Factors; Secondary Prevention; Thromboxane A2; Treatment Outcome | 2012 |
Mechanisms of aspirin resistance.
Topics: Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Interactions; Drug Resistance; Humans; Integrin beta3; Medication Adherence; Tachyphylaxis; Thromboembolism; Thromboxane A2; Treatment Failure | 2014 |
Role of platelets in inflammation and cancer: novel therapeutic strategies.
Topics: Animals; Aspirin; Blood Platelets; Cardiovascular Diseases; Colorectal Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Endothelial Cells; Humans; Inflammation; Leukocytes; Neoplasms; Platelet Activation; Platelet Aggregation Inhibitors; Stromal Cells; Thromboxane A2; Up-Regulation | 2014 |
Oxidative stress-related mechanisms affecting response to aspirin in diabetes mellitus.
Topics: Aldehyde Reductase; Aspirin; Blood Platelets; Diabetes Mellitus, Type 2; F2-Isoprostanes; Glucose; Glycosylation; Humans; Lipid Peroxides; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Platelet Activation; Platelet Aggregation Inhibitors; Thrombosis; Thromboxane A2 | 2015 |
Platelets in patients with aspirin-exacerbated respiratory disease.
Topics: Animals; Aspirin; Asthma, Aspirin-Induced; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Movement; Clinical Trials as Topic; Eosinophils; Gene Expression; Humans; Leukotrienes; Oxazoles; Piperazines; Platelet Activating Factor; Platelet Activation; Prasugrel Hydrochloride; Receptors, Leukotriene; Thiophenes; Thromboxane A2 | 2015 |
Aspirin for primary prevention in diabetes mellitus: from the calculation of cardiovascular risk and risk/benefit profile to personalised treatment.
Topics: Animals; Aspirin; Biomarkers, Pharmacological; Blood Platelets; Cardiovascular Diseases; Cyclooxygenase 1; Diabetes Mellitus, Type 2; Humans; Platelet Activation; Precision Medicine; Risk Assessment; Thromboxane A2 | 2015 |
The Effect of Aspirin on the Prevention of Pro-thrombotic States in Hospitalized COVID-19 Patients: Systematic Review.
Topics: Antiviral Agents; Aspirin; COVID-19 Drug Treatment; Humans; Interleukin-6; Lipoxins; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Prostaglandins; SARS-CoV-2; Thrombosis; Thromboxane A2 | 2022 |
85 trial(s) available for aspirin and thromboxane a2
| Article | Year |
|---|---|
[Aspirin in the prevention of thromboembolic diseases].
Topics: Animals; Aspirin; Clinical Trials as Topic; Depression, Chemical; Epoprostenol; Humans; Platelet Aggregation; Rats; Thromboembolism; Thromboxane A2 | 1978 |
Importance of reperfusion on thromboxane A2 metabolite excretion after thrombolysis.
Topics: Aspirin; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Platelet Activation; Streptokinase; Thrombolytic Therapy; Thromboxane A2; Thromboxane B2; Tissue Plasminogen Activator | 1992 |
[The effect of low-dose acetylsalicylic acid on platelet aggregation parameters in vitro].
Topics: Aspirin; Dipyridamole; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Platelet Aggregation; Preoperative Care; Thromboxane A2; Time Factors | 1992 |
Different interactions of platelets with arterial and venous coronary bypass vessels.
Topics: Apyrase; Arginine; Aspirin; Blood Platelets; Coronary Artery Bypass; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; In Vitro Techniques; Indomethacin; Isometric Contraction; Ketanserin; Mammary Arteries; Muscle, Smooth, Vascular; Norepinephrine; omega-N-Methylarginine; Platelet Aggregation; Saphenous Vein; Thromboxane A2 | 1991 |
[Pharmacological correction by roxicam of the prostacyclin-thromboxane system in acute myocardial infarction complicated by heart failure].
Topics: 6-Ketoprostaglandin F1 alpha; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiac Glycosides; Diuretics; Epoprostenol; Heart Failure; Humans; Myocardial Infarction; Nitrates; Piroxicam; Thromboxane A2; Thromboxane B2; Thromboxanes | 1991 |
Prevention of restenosis after percutaneous transluminal coronary angioplasty with thromboxane A2-receptor blockade. A randomized, double-blind, placebo-controlled trial. Coronary Artery Restenosis Prevention on Repeated Thromboxane-Antagonism Study (CARP
Topics: Angioplasty, Balloon, Coronary; Aspirin; Biphenyl Compounds; Constriction, Pathologic; Coronary Disease; Double-Blind Method; Female; Follow-Up Studies; Heptanoic Acids; Humans; Male; Middle Aged; Receptors, Prostaglandin; Receptors, Thromboxane; Recurrence; Thromboxane A2 | 1991 |
Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirin.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Bradykinin; Delayed-Action Preparations; Depression, Chemical; Drug Administration Schedule; Epoprostenol; Humans; Male; Middle Aged; Salicylates; Thromboxane A2 | 1991 |
The effect of enteric-coated aspirin on the morning increase in platelet activity.
Topics: Adult; Aspirin; Blood Platelets; Circadian Rhythm; Humans; Male; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Single-Blind Method; Tablets, Enteric-Coated; Thromboxane A2; Tissue Plasminogen Activator | 1991 |
Effect of low-dose aspirin on vascular refractoriness in angiotensin-sensitive primigravid women.
Topics: Administration, Oral; Adolescent; Adult; Angiotensin II; Aspirin; Blood Pressure; Double-Blind Method; Drug Antagonism; Female; Heart Rate; Humans; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, Third; Thromboxane A2; Vasoconstriction | 1991 |
[Drug modulation of thromboxane A2/prostacyclin balance and lipid peroxidation in patients with coronary artery disease].
Topics: Aged; Aspirin; Coronary Disease; Diltiazem; Epoprostenol; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Superoxide Dismutase; Thromboxane A2 | 1990 |
Effect of aspirin and dipyridamole treatment on prostacyclin production by human veins.
Topics: Aspirin; Dipyridamole; Double-Blind Method; Endothelium, Vascular; Epoprostenol; Humans; Prospective Studies; Randomized Controlled Trials as Topic; Saphenous Vein; Thromboxane A2; Varicose Veins | 1990 |
Effect of aspirin infusions on platelet function in humans.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Time Factors | 1990 |
Comparison of low-dose aspirin and coronary vasodilators in acute unstable angina.
Topics: Angina Pectoris; Angina, Unstable; Aspirin; Diltiazem; Drug Therapy, Combination; Electrocardiography; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Platelet Aggregation; Randomized Controlled Trials as Topic; Thromboxane A2; Thromboxane B2 | 1990 |
Thromboxane biosynthesis in allergen-induced bronchospasm. Evidence for platelet activation.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Allergens; Aspirin; Blood Platelets; Bronchial Spasm; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Female; Forced Expiratory Volume; Gas Chromatography-Mass Spectrometry; Humans; Male; Placebos; Platelet Activation; Thromboxane A2; Thromboxane B2 | 1989 |
Improvement of renal function with selective thromboxane antagonism in lupus nephritis.
Topics: Adolescent; Adult; Aged; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Kidney; Lupus Nephritis; Male; Middle Aged; Random Allocation; Renal Circulation; Sulfonamides; Thromboxane A2 | 1989 |
The use of aspirin to prevent pregnancy-induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies.
Topics: Adult; Aspirin; Clinical Trials as Topic; Double-Blind Method; Epoprostenol; Female; Humans; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Prospective Studies; Random Allocation; Thromboxane A2 | 1989 |
Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Epoprostenol; Female; Fetus; Humans; Hypertension; Pregnancy; Pregnancy Complications, Cardiovascular; Random Allocation; Thromboxane A2; Thromboxane B2; Thromboxanes | 1989 |
Role of thromboxane A2 as a mediator of platelet-activating-factor-induced aggregation of human platelets.
Topics: Adult; Aspirin; Collagen; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Serotonin; Thromboxane A2; Thromboxane B2 | 1989 |
Effects of intermittent treatment with aspirin on thromboxane and prostacyclin formation in patients with acute myocardial infarction.
Topics: Administration, Oral; Aged; Aspirin; Drug Administration Schedule; Epoprostenol; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Thromboxane A2 | 1988 |
Is there an optimal dose and formulation of aspirin to prevent arterial thrombo-embolism in man?
Topics: Aspirin; Blood Platelets; Blood Vessels; Chemistry, Pharmaceutical; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Epoprostenol; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation; Pregnancy; Thromboembolism; Thromboxane A2 | 1986 |
Prevention of recurrent idiopathic fetal growth retardation by low-dose aspirin and dipyridamole.
Topics: Adult; Aspirin; Birth Weight; Clinical Trials as Topic; Dipyridamole; Epoprostenol; Female; Fetal Growth Retardation; Humans; Infant, Newborn; Pregnancy; Recurrence; Thromboxane A2 | 1987 |
Absence of differential inhibition of thromboxane A2 and prostacyclin by low and high dose aspirin in coronary artery disease.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aspirin; Coronary Disease; Electrocardiography; Epoprostenol; Humans; Lactates; Lactic Acid; Male; Middle Aged; Thromboxane A2; Thromboxane B2 | 1987 |
A dose-ranging study of the antiplatelet effect of enteric coated aspirin in man.
Topics: Adult; Aspirin; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation; Thrombosis; Thromboxane A2; Thromboxane B2 | 1987 |
Effects of low-dose aspirin on responses to furosemide.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Body Weight; Eicosanoic Acids; Electrolytes; Female; Furosemide; Humans; Male; Radioimmunoassay; Renin; Thromboxane A2; Time Factors | 1986 |
Effect of alternate-day regular and enteric-coated aspirin on platelet aggregation, bleeding time, and thromboxane A2 levels in bleeding-time blood.
Topics: Adult; Aspirin; Bleeding Time; Blood Platelets; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Platelet Aggregation; Random Allocation; Tablets, Enteric-Coated; Thromboxane A2 | 1986 |
Effect of preoperative antiplatelet drugs on vascular prostacyclin synthesis.
Topics: Aspirin; Blood Platelets; Blood Vessels; Coronary Disease; Dipyridamole; Drug Evaluation; Drug Therapy, Combination; Epoprostenol; Humans; Platelet Aggregation; Premedication; Thromboxane A2; Thromboxane B2 | 1987 |
Inhibition of prostacyclin and thromboxane A2 generation by low-dose aspirin at the site of plug formation in man in vivo.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Bleeding Time; Blood Platelets; Blood Vessels; Double-Blind Method; Epoprostenol; Hemostasis; Humans; Male; Thrombosis; Thromboxane A2; Thromboxane B2 | 1987 |
Effects of low doses of aspirin, 10 mg and 30 mg daily, on bleeding time, thromboxane production and 6-keto-PGF1 alpha excretion in healthy subjects.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Bleeding Time; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Function Tests; Thromboxane A2; Thromboxane B2; Thromboxanes; Time Factors | 1987 |
Coronary vasoconstrictor response to cold pressor test in variant angina: lack of relation to intracoronary thromboxane concentrations.
Topics: Adult; Angina Pectoris, Variant; Angiography; Aorta; Aspirin; Blood Pressure; Cold Temperature; Coronary Circulation; Hemodynamics; Humans; Male; Middle Aged; Osmolar Concentration; Thromboxane A2; Thromboxane B2; Vasoconstriction | 1987 |
Low-dose aspirin in patients recovering from myocardial infarction. Evidence for a selective inhibition of thromboxane-related platelet function.
Topics: Adult; Aged; Aspirin; Bleeding Time; Blood Platelets; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Infarction; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Thromboxane B2 | 1985 |
Differential inhibition by low-dose aspirin of human venous prostacyclin synthesis and platelet thromboxane synthesis.
Topics: Aspirin; Blood Platelets; Depression, Chemical; Epoprostenol; Humans; Platelet Aggregation; Prostaglandins; Thromboxane A2; Thromboxanes; Veins | 1981 |
Prostaglandins and endometriosis.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Clinical Trials as Topic; Endometriosis; Epoprostenol; Female; Humans; In Vitro Techniques; Indomethacin; ortho-Aminobenzoates; Prostaglandin Antagonists; Prostaglandins; Thromboxane A2; Thromboxane B2; Thromboxanes | 1983 |
Prostacyclin and thromboxane in ovarian cancer: effect of cytostatics and prostaglandin synthesis inhibitors.
Topics: 6-Ketoprostaglandin F1 alpha; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Epoprostenol; Female; Humans; Indomethacin; Ovarian Neoplasms; Thromboxane A2; Thromboxane B2; Thromboxanes | 1983 |
A regimen for low-dose aspirin?
Topics: Adult; Aspirin; Blood Platelets; Drug Administration Schedule; Epoprostenol; Female; Humans; Male; Malondialdehyde; Middle Aged; Serotonin; Thromboxane A2 | 1982 |
Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials.
Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Arteries; Aspirin; Clinical Trials as Topic; Coronary Circulation; Coronary Vessels; Double-Blind Method; Female; Humans; Indomethacin; Ischemia; Male; Middle Aged; Recurrence; Thromboxane A2; Thromboxane B2; Thromboxanes; Time Factors; Veins | 1981 |
Prostacyclin, thromboxane and prostaglandin F2 alpha in suction blister fluid of human skin: effect of systemic aspirin and local glucocorticosteroid treatment.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Betamethasone; Blister; Clobetasol; Dinoprost; Epoprostenol; Exudates and Transudates; Humans; Male; Prostaglandins; Prostaglandins F; Skin; Thromboxane A2; Thromboxane B2; Thromboxanes | 1981 |
Effect of thromboxane A2 blockade on clinical outcome and restenosis after successful coronary angioplasty. Multi-Hospital Eastern Atlantic Restenosis Trial (M-HEART II)
Topics: Angioplasty, Balloon, Coronary; Aspirin; Coronary Angiography; Coronary Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Sulfonamides; Thromboxane A2; Time Factors; Treatment Outcome | 1995 |
Effects of unfractionated and low molecular weight heparins on platelet thromboxane biosynthesis "in vivo".
Topics: Adult; Aspirin; Blood Platelets; Evaluation Studies as Topic; Female; Heparin; Heparin, Low-Molecular-Weight; Humans; Male; Middle Aged; Thromboxane A2; Thromboxane B2 | 1994 |
Effects of low-dose aspirin on in vitro platelet aggregation in the early minutes after ingestion in normal subjects.
Topics: Administration, Oral; Adult; Arachidonic Acid; Aspirin; Cross-Over Studies; Female; Humans; Longitudinal Studies; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Time Factors | 1994 |
The role of extraplatelet thromboxane A2 in unstable angina investigated with a dual thromboxane A2 inhibitor: importance of activated monocytes.
Topics: Aged; Angina Pectoris; Angina, Unstable; Aspirin; Double-Blind Method; Female; Follow-Up Studies; Humans; Leukocytes, Mononuclear; Lymphocytes; Male; Middle Aged; Myocardial Ischemia; Phthalic Acids; Placebos; Platelet Aggregation Inhibitors; Prospective Studies; Thromboxane A2 | 1994 |
Low dose aspirin in hypertensive pregnant women: effect on pregnancy outcome and prostacyclin-thromboxane balance in mother and newborn.
Topics: Adult; Aspirin; Drug Administration Schedule; Epoprostenol; Female; Humans; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Prospective Studies; Thromboxane A2; Time Factors | 1993 |
Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction. The Ridogrel Versus Aspir
Topics: Aged; Aspirin; Coronary Angiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Pentanoic Acids; Pyridines; Receptors, Prostaglandin; Receptors, Thromboxane; Thrombolytic Therapy; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Treatment Outcome; Vascular Patency | 1994 |
The effect of regular and enteric-coated aspirin on bleeding time, thromboxane, and prostacyclin.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Aspirin; Bleeding Time; Dosage Forms; Eicosanoids; Epoprostenol; Humans; Male; Middle Aged; Tablets, Enteric-Coated; Thromboxane A2; Thromboxane B2 | 1993 |
Aspirin, but not heparin, suppresses the transient increase in thromboxane biosynthesis associated with cardiac catheterization or coronary angioplasty.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiac Catheterization; Dose-Response Relationship, Drug; Female; Heparin; Humans; Male; Middle Aged; Models, Cardiovascular; Platelet Activation; Thromboxane A2; Thromboxane B2 | 1993 |
Rapid and selective inhibition of platelet aggregation and thromboxane formation by intravenous low dose aspirin in man.
Topics: Adult; Aspirin; Blood Platelets; Drug Administration Schedule; Humans; Infusions, Intravenous; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Prostaglandins; Single-Blind Method; Thromboxane A2 | 1993 |
[Low doses of acetylsalicylic acid effectively inhibits thrombocyte aggregation after ischemic stroke].
Topics: Aged; Aged, 80 and over; Aspirin; Blood Coagulation Tests; Brain Ischemia; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins F; Thromboxane A2; Thromboxane B2 | 1996 |
Comparison of aspirin with a thromboxane antagonist for patients with prolonged chest pain and ST segment depression.
Topics: Aged; Aspirin; Biphenyl Compounds; Coronary Care Units; Double-Blind Method; Electrocardiography; Female; Heptanoic Acids; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Platelet Aggregation Inhibitors; Recurrence; Streptokinase; Thromboxane A2 | 1996 |
Dose-related effects of low dose aspirin on hemostasis parameters and prostacyclin/thromboxane ratios in late pregnancy.
Topics: Adolescent; Adult; Aspirin; Bleeding Time; Blood Coagulation; Dose-Response Relationship, Drug; Epoprostenol; Female; Humans; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Thromboxane A2 | 1996 |
Aspirin in polycythemia vera and essential thrombocythemia: current facts and perspectives.
Topics: Adult; Aged; Aspirin; Cyclooxygenase Inhibitors; Erythromelalgia; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Polycythemia Vera; Thrombocythemia, Essential; Thromboxane A2 | 1996 |
Diabetes mellitus, hypercholesterolemia, and hypertension but not vascular disease per se are associated with persistent platelet activation in vivo. Evidence derived from the study of peripheral arterial disease.
Topics: Adult; Aged; Aspirin; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Multivariate Analysis; Platelet Activation; Prospective Studies; Reproducibility of Results; Risk Factors; Smoking; Thromboxane A2; Thromboxane B2; Vascular Diseases | 1997 |
Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production.
Topics: Abortion, Habitual; Adult; Aspirin; Autoimmune Diseases; Blood Platelets; Epoprostenol; Female; Humans; Pregnancy; Thromboxane A2; Thromboxane B2 | 1997 |
Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina.
Topics: Aged; Angina, Unstable; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Isoenzymes; Isoindoles; Male; Membrane Proteins; Middle Aged; Phenylbutyrates; Prostaglandin-Endoperoxide Synthases; Reference Values; Thromboxane A2; Thromboxane B2 | 1997 |
Continued thromboxane A2 formation despite administration of a platelet glycoprotein IIb/IIIa antagonist in patients undergoing coronary angioplasty.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Biphenyl Compounds; Bleeding Time; Cell Division; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Fibrinogen; Heparin; Humans; Infusions, Intravenous; Male; Middle Aged; Muscle, Smooth, Vascular; P-Selectin; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyrrolidines; Thrombosis; Thromboxane A2; Thromboxane B2; Vasoconstriction | 1997 |
In the dose range of 0.5-2.0 mg/kg, acetylsalicylic acid does not affect prostacyclin production in hypertensive pregnancies.
Topics: Aspirin; Epoprostenol; Female; Humans; Hypertension; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy Complications, Cardiovascular; Thromboxane A2 | 1999 |
Increased thromboxane biosynthesis is associated with poststroke dementia.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Brain Ischemia; Cerebral Hemorrhage; Chronic Disease; Cognition; Creatinine; Dementia, Vascular; Female; Humans; Male; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Radioimmunoassay; Thromboxane A2; Thromboxane B2 | 1999 |
Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Epoprostenol; F2-Isoprostanes; Female; Humans; Isoenzymes; Macrophages; Male; Membrane Proteins; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Thromboxane A2; Thromboxane B2 | 2000 |
Oxidant stress and aspirin-insensitive thromboxane biosynthesis in severe unstable angina.
Topics: Angina, Unstable; Antioxidants; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprost; Dose-Response Relationship, Drug; Drug Resistance; F2-Isoprostanes; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; Oxidative Stress; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Time Factors | 2000 |
Time course inhibition of gastric and platelet COX activity by acetylsalicylic acid in humans.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Female; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Prostaglandin-Endoperoxide Synthases; Regression Analysis; Stomach Ulcer; Thromboxane A2; Time Factors | 2000 |
Incomplete thromboxane inhibition with 100 mg of intravenous acetylsalicylic acid in patients with acute ST elevation myocardial infarction: a placebo-controlled pilot trial.
Topics: Aged; Aspirin; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Humans; Injections, Intravenous; Male; Middle Aged; Myocardial Infarction; Pilot Projects; Streptokinase; Thromboxane A2; Thromboxane B2; Thromboxanes | 2001 |
Improved endothelial function by the thromboxane A2 receptor antagonist S 18886 in patients with coronary artery disease treated with aspirin.
Topics: Acetylcholine; Aged; Aspirin; Coronary Artery Disease; Cyclooxygenase Inhibitors; Double-Blind Method; Endothelium, Vascular; Forearm; Humans; Male; Middle Aged; Naphthalenes; Nitroprusside; Norepinephrine; Propionates; Receptors, Thromboxane; Regional Blood Flow; Tetrahydronaphthalenes; Thromboxane A2; Treatment Outcome; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2003 |
Optimal suppression of thromboxane A(2) formation by aspirin during percutaneous transluminal coronary angioplasty: no additional effect of a selective cyclooxygenase-2 inhibitor.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Biphenyl Compounds; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprost; Epoprostenol; Female; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; Peroxidases; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prostaglandin-Endoperoxide Synthases; Pyrrolidines; Sulfonamides; Thromboxane A2 | 2004 |
Reduction of daily life ischaemia by aspirin in patients with angina: underlying link between thromboxane A2 and macrophage colony stimulating factor.
Topics: Adult; Aged; Aspirin; Biomarkers; Cohort Studies; Coronary Artery Disease; Cross-Over Studies; Double-Blind Method; Electrocardiography, Ambulatory; Female; Humans; Interleukin-6; Macrophage Colony-Stimulating Factor; Male; Middle Aged; Myocardial Ischemia; Peptide Fragments; Platelet Aggregation Inhibitors; Prothrombin; Thromboxane A2; Thromboxane B2 | 2004 |
Pharmacokinetics and pharmacodynamics of terbogrel, a combined thromboxane A2 receptor and synthase inhibitor, in healthy subjects.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Bleeding Time; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Platelet Aggregation; Pyridines; Thromboxane A2; Thromboxane-A Synthase | 2004 |
Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans.
Topics: Administration, Oral; Adult; Aspirin; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Duodenum; Flow Cytometry; Gastric Mucosa; Humans; Intestinal Mucosa; Male; Monocytes; Platelet Activation; Platelet Aggregation Inhibitors; Reference Values; Single-Blind Method; Stomach; Thromboxane A2; Thromboxane B2 | 2004 |
Picotamide, a combined inhibitor of thromboxane A2 synthase and receptor, reduces 2-year mortality in diabetics with peripheral arterial disease: the DAVID study.
Topics: Adult; Aged; Aspirin; Diabetic Angiopathies; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Peripheral Vascular Diseases; Phthalic Acids; Platelet Aggregation Inhibitors; Risk Factors; Survival Analysis; Thromboxane A2 | 2004 |
Prostacyclin, thromboxane A and the effect of low-dose ASA in pregnancies at high risk for hypertensive disorders.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Female; Humans; Hypertension, Pregnancy-Induced; Longitudinal Studies; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Pregnancy, High-Risk; Prostaglandins; Thromboxane A2; Thromboxane B2 | 2004 |
Persistent production of platelet thromboxane A2 in patients chronically treated with aspirin.
Topics: Aged; Aspirin; Blood Platelets; Cardiovascular Diseases; Collagen; Cyclooxygenase 1; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Thromboxane A2 | 2005 |
Thromboxane-dependent CD40 ligand release in type 2 diabetes mellitus.
Topics: Aged; Aspirin; CD40 Ligand; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dinoprost; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Oxidative Stress; Platelet Activation; Platelet Aggregation Inhibitors; Radioimmunoassay; Thromboxane A2; Thromboxane B2 | 2006 |
A study of aspirin and clopidogrel in idiopathic pulmonary arterial hypertension.
Topics: Adult; Aspirin; Clopidogrel; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2; Ticlopidine | 2006 |
Biological efficacy of low against medium dose aspirin regimen after coronary surgery: analysis of platelet function.
Topics: Adenosine Diphosphate; Administration, Oral; Adult; Aged; Aspirin; Blood Platelets; Collagen; Coronary Artery Bypass; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Complications; Thromboxane A2; Time Factors | 2006 |
Heterogeneity in the suppression of platelet cyclooxygenase-1 activity by aspirin in coronary heart disease.
Topics: Aged; Arachidonic Acid; Aspirin; Blood Platelets; Calcimycin; Coronary Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; Humans; Indans; Lipopolysaccharides; Male; Middle Aged; Neutrophils; Thromboxane A2; Thromboxane B2 | 2006 |
Persistent platelet activation in patients with type 2 diabetes treated with low doses of aspirin.
Topics: Aspirin; Biomarkers; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Glycemic Index; Humans; Inflammation; Platelet Activation; Thromboxane A2 | 2007 |
Aspirin therapy and thromboxane biosynthesis in systemic lupus erythematosus.
Topics: Adult; Aspirin; Cyclooxygenase Inhibitors; Drug Resistance; Epoprostenol; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Thromboxane A2 | 2007 |
Alternative splicing of platelet cyclooxygenase-2 mRNA in patients after coronary artery bypass grafting.
Topics: Administration, Oral; Alternative Splicing; Animals; Aspirin; Base Sequence; Blood Platelets; Chlorocebus aethiops; Coronary Artery Bypass; Coronary Artery Disease; COS Cells; Cyclooxygenase 2; Drug Resistance; Epoprostenol; Frameshifting, Ribosomal; Humans; Isoenzymes; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleic Acid Conformation; Platelet Aggregation; Platelet Aggregation Inhibitors; RNA, Messenger; Thromboxane A2; Transfection; Treatment Outcome; Up-Regulation | 2007 |
Lack of biological relevance of platelet cyclooxygenase-2 dependent thromboxane A2 production.
Topics: Aged; Algorithms; Aspirin; Blood Platelets; Cardiovascular Diseases; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Resistance; Female; Hematology; Humans; Male; Middle Aged; Patient Compliance; Platelet Aggregation Inhibitors; Thromboxane A2 | 2008 |
The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy.
Topics: Adult; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Etoricoxib; Female; Humans; Immunohistochemistry; Male; Middle Aged; Platelet Aggregation Inhibitors; Pyridines; Sulfones; Thrombocythemia, Essential; Thromboxane A2; Thromboxane B2; Thromboxanes; Treatment Outcome | 2010 |
Effect of atorvastatin on platelet thromboxane A(2) synthesis in aspirin-treated patients with acute myocardial infarction.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Atorvastatin; Blood Platelets; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Pyrroles; Thromboxane A2; Treatment Outcome | 2009 |
Reduction of platelet thromboxane A2 production ex vivo and in vivo by clopidogrel therapy.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Clopidogrel; Down-Regulation; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thromboxane A2; Thromboxane B2; Ticlopidine; Young Adult | 2010 |
Heterogeneity in platelet cyclooxygenase inhibition by aspirin in coronary artery disease.
Topics: Adult; Aspirin; Coronary Artery Disease; Cyclooxygenase Inhibitors; Female; Genetic Heterogeneity; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Thromboxane B2 | 2011 |
A randomized, quadruple crossover single-blind study on immediate action of chewed and unchewed low-dose acetylsalicylic acid tablets in healthy volunteers.
Topics: Administration, Oral; Adult; Area Under Curve; Aspirin; Cross-Over Studies; Humans; Mastication; Middle Aged; Platelet Aggregation; Reference Values; Single-Blind Method; Tablets; Thromboxane A2 | 2011 |
Aspirin-insensitive thromboxane biosynthesis in essential thrombocythemia is explained by accelerated renewal of the drug target.
Topics: Acceleration; Adult; Aged; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Cross-Sectional Studies; Cyclooxygenase 1; Cyclooxygenase 2; Drug Resistance; Female; Half-Life; Humans; Male; Metabolic Networks and Pathways; Middle Aged; Molecular Targeted Therapy; Protein Biosynthesis; Thrombocythemia, Essential; Thromboxane A2 | 2012 |
Thromboxane A(2) generation, in the absence of platelet COX-1 activity, in patients with and without atherothrombotic myocardial infarction.
Topics: Aged; Aspirin; Blood Platelets; Coronary Artery Disease; Creatinine; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Thrombosis; Thromboxane A2; Thromboxane B2 | 2013 |
Low dose aspirin and low-molecular-weight heparin in the treatment of pregnant Libyan women with recurrent miscarriage.
Topics: Abortion, Habitual; Adult; Aspirin; Birth Weight; Embryo Implantation; Enoxaparin; Female; Fibrinolytic Agents; Humans; Infant, Newborn; Libya; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Outcome; Prostaglandins I; Thrombophilia; Thromboxane A2; Trophoblasts; Vasodilation; Young Adult | 2014 |
In vivo prostacyclin biosynthesis and effects of different aspirin regimens in patients with essential thrombocythaemia.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aspirin; Blood Platelets; Clinical Protocols; Drug Dosage Calculations; Epoprostenol; Female; Humans; Male; Middle Aged; Platelet Aggregation; Thrombocythemia, Essential; Thromboxane A2 | 2014 |
Targeting the COX1/2-Driven thromboxane A2 pathway suppresses Barrett's esophagus and esophageal adenocarcinoma development.
Topics: Adenocarcinoma; Animals; Aspirin; Barrett Esophagus; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Esophageal Neoplasms; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Inflammation; Male; Mice, Inbred C57BL; Middle Aged; Molecular Targeted Therapy; Signal Transduction; STAT3 Transcription Factor; Thromboxane A2 | 2019 |
417 other study(ies) available for aspirin and thromboxane a2
| Article | Year |
|---|---|
Salicylic acid fails to inhibit generation of thromboxane A2 activity in platelets after in vivo administration to the rat.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Platelets; Depression, Chemical; Male; Platelet Aggregation; Rats; Salicylates; Thromboxane A2; Thromboxanes; Time Factors | 1978 |
Aspirin, thromboxane, and prostacyclin in rats: A dilemma resolved?
Topics: Animals; Aspirin; Blood Platelets; Blood Vessels; Epoprostenol; Male; Platelet Aggregation; Prostaglandin Antagonists; Prostaglandins; Rats; Thromboxane A2; Thromboxanes | 1978 |
Aspirin and bleeding-time.
Topics: Aspirin; Dose-Response Relationship, Drug; Epoprostenol; Hemorrhage; Humans; Platelet Aggregation; Thromboxane A2; Time Factors | 1978 |
The inhibition of cyclo-oxygenase of rabbit platelets by aspirin is prevented by salicylic acid and by phenanthrolines.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dithiothreitol; In Vitro Techniques; Indomethacin; Phenanthrolines; Platelet Aggregation; Rabbits; Salicylates; Thromboxane A2; Time Factors | 1978 |
[Effect of factor VIII concentrate on malondialdehyde release by normal human platelets].
Topics: Adult; Aspirin; Blood Coagulation; Blood Platelets; Collagen; Epinephrine; Ethylmaleimide; Factor VIII; Female; Heparin; Humans; Male; Malonates; Malondialdehyde; Platelet Aggregation; Thrombin; Thromboxane A2 | 1979 |
9, 11-Azo-12-oxa-15-hydroxyprostanoic acid: a potent thromboxane synthetase inhibitor and a PGH2/TxA2 receptor antagonist.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Humans; Microsomes; Oxidoreductases; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Cell Surface; Receptors, Prostaglandin; Swine; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes | 1979 |
[Perspectives in science].
Topics: Aspirin; Blood Coagulation; Epoprostenol; Humans; Thromboxane A2 | 1977 |
Lungs as a generator of prostacyclin--hypothesis on physiological significance.
Topics: Animals; Arachidonic Acids; Aspirin; Cats; Epoprostenol; Guinea Pigs; Lung; Male; Platelet Aggregation; Positive-Pressure Respiration; Prostaglandins; Rats; Thromboxane A2 | 1978 |
Prostaglandins and aspirin-sensitive asthma.
Topics: Aspirin; Asthma; Depression, Chemical; Epoprostenol; Humans; Prostaglandins; Prostaglandins E; Thromboxane A2 | 1978 |
Prostacyclin (PGI2) and thromboxane A2 interaction in vivo. Regulation by aspirin and relationship with anti-thrombotic therapy.
Topics: Animals; Arachidonic Acids; Aspirin; Cats; Dose-Response Relationship, Drug; Drug Interactions; Epoprostenol; Fibrinolytic Agents; Injections, Intravenous; Male; Platelet Aggregation; Prostaglandins; Rabbits; Thromboxane A2; Thromboxanes | 1978 |
The role of platelet-activating factor in platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation Factors; Calcimycin; Calcium; Creatine Kinase; Humans; Lysophosphatidylcholines; Phosphocreatine; Phospholipases; Platelet Aggregation; Rabbits; Thromboxane A2 | 1979 |
Prostacyclin, thromboxane A2 interactions in haemostasis and thrombosis.
Topics: Animals; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Epoprostenol; Humans; Platelet Aggregation; Prostaglandins; Thrombosis; Thromboxane A2; Thromboxanes | 1979 |
Biotransformation and cardiovascular effects of arachidonic acid in the dog.
Topics: Animals; Arachidonic Acids; Aspirin; Biotransformation; Dogs; Female; Hemodynamics; Indomethacin; Male; Prostaglandins H; Thromboxane A2 | 1979 |
Indobufen, a new inhibitor of platelet aggregation. Studies in guinea pigs.
Topics: Animals; Aspirin; Blood Platelets; Blood Specimen Collection; Dipyridamole; Guinea Pigs; In Vitro Techniques; Indoles; Indomethacin; Isoindoles; Phenylbutyrates; Platelet Aggregation; Prostaglandins; Prothrombin Time; Serotonin; Thrombin; Thromboxane A2; Time Factors | 1979 |
Platelet aggregability, thromboxane A2 and malonaldehyde formation following administration of aspirin to man.
Topics: Adult; Arachidonic Acids; Aspirin; Blood Platelets; Coronary Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Malonates; Malondialdehyde; Middle Aged; Myocardial Infarction; Platelet Aggregation; Thromboxane A2; Thromboxanes | 1979 |
Prolonged paradoxical effect of aspirin on platelet behaviour and bleeding time in man.
Topics: Adult; Aspirin; Bleeding Time; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Partial Thromboplastin Time; Platelet Aggregation; Salicylates; Thromboxane A2; Time Factors | 1979 |
Platelet effects of arachidonic acid in dog blood. II. Involvement of cyclo-oxygenase in the in vitro situation.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Platelets; Dogs; Drug Interactions; Erythrocytes; Ethanol; Humans; Linoleic Acids; Oxygenases; Platelet Aggregation; Rabbits; Saponins; Thrombocytopenia; Thromboxane A2 | 1977 |
Prostaglandin E2 and epinephrine participate in cyclical reduction of coronary blood pressure and flow.
Topics: Animals; Aspirin; Blood Flow Velocity; Blood Pressure; Coronary Circulation; Dogs; Epinephrine; Glutathione; Platelet Aggregation; Prostaglandins E; Thromboxane A2 | 1978 |
Unstable metabolites of arachidonic acid aspirin and the formation of the haemostatic plug.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Coagulation Tests; Dose-Response Relationship, Drug; Hemostasis; Linoleic Acids; Male; Prostaglandins G; Rabbits; Thrombosis; Thromboxane A2 | 1978 |
Disturbed lipid metabolism in diabetic coronary vessels.
Topics: Alloxan; Animals; Arachidonic Acids; Aspirin; Coronary Circulation; Coronary Vessels; Diabetes Mellitus, Experimental; Dogs; Epoprostenol; Female; Indomethacin; Male; Microcirculation; Myocardium; Norepinephrine; Phentolamine; Prazosin; Prostaglandin-Endoperoxide Synthases; Receptors, Adrenergic, alpha; Thromboxane A2; Vasoconstriction | 1992 |
Increased thromboxane biosynthesis in patients with polycythemia vera: evidence for aspirin-suppressible platelet activation in vivo.
Topics: Adult; Aged; Aspirin; Blood Platelets; Female; Humans; Kinetics; Leukotriene E4; Male; Middle Aged; Platelet Activation; Polycythemia Vera; SRS-A; Thromboxane A2; Thromboxane B2 | 1992 |
Urinary 11-dehydro-thromboxane B2: a quantitative index of platelet activation in cerebral infarction.
Topics: Adult; Aged; Arteriosclerosis; Aspirin; Atrial Fibrillation; Carotid Artery Diseases; Cerebral Infarction; Female; Humans; Male; Middle Aged; Platelet Activation; Thromboxane A2; Thromboxane B2 | 1992 |
Low concentrations of sodium azide specifically inhibit a thromboxane A2 pathway in human platelets.
Topics: Adenosine Diphosphate; Apyrase; Arachidonic Acid; Aspirin; Azides; Blood Platelets; Calcium; Collagen; Energy Metabolism; Enzyme Activation; Humans; Hydrogen-Ion Concentration; Myosin-Light-Chain Kinase; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Secretory Rate; Serotonin; Sodium Azide; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2 | 1992 |
Effects of low-to-high doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclin.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aspirin; Cerebrovascular Disorders; Dose-Response Relationship, Drug; Epoprostenol; Female; Humans; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1992 |
Effect of dipyridamole with or without aspirin on urine protein excretion in patients with membranous glomerulonephritis.
Topics: Adult; Aspirin; Dipyridamole; Drug Therapy, Combination; Female; Glomerulonephritis, Membranous; Humans; Kidney Function Tests; Male; Platelet Aggregation; Proteinuria; Thromboxane A2 | 1992 |
Photochemically induced thrombosis of the rat coronary artery and functional evaluation of thrombus formation by occurrence of ventricular arrhythmias. Effects of acetylsalicylic acid and a thromboxane A2 synthetase inhibitor of thrombus formation.
Topics: Animals; Arrhythmias, Cardiac; Aspirin; Coronary Thrombosis; Histocytochemistry; Imidazoles; Male; Myocardium; Photochemistry; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Thromboxane A2; Thromboxane-A Synthase; Ventricular Function | 1992 |
Evidence for a role in thrombus stabilization for thromboxane A2 in human platelet deposition on collagen.
Topics: Aspirin; Biphenyl Compounds; Blood Platelets; Citrates; Collagen; Heparin; Heptanoic Acids; Humans; In Vitro Techniques; Kinetics; Microscopy, Electron, Scanning; Platelet Adhesiveness; Receptors, Prostaglandin; Receptors, Thromboxane; Thrombosis; Thromboxane A2 | 1992 |
Comparison of hypoxia-induced contraction in human, monkey, and dog coronary arteries.
Topics: Animals; Aspirin; Coronary Vessels; Dinoprost; Dogs; Endothelium, Vascular; Female; Humans; Hypoxia; In Vitro Techniques; Indomethacin; Isometric Contraction; Macaca; Male; Methacrylates; Muscle Relaxation; Muscle, Smooth, Vascular; Papaverine; Prostaglandins; Species Specificity; Superoxide Dismutase; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 1992 |
Acute in vitro effects of ethanol on responses of platelets from cholesterol-fed and Watanabe heritable hyperlipidemic rabbits.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Cholesterol, Dietary; Collagen; Ethanol; Hyperlipidemias; Male; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Thrombin; Thromboxane A2 | 1992 |
Putative mechanism of hypotensive action of platelet-activating factor in dogs.
Topics: Animals; Aspirin; Blood Pressure; Cardiac Output; Dogs; Female; Hemodynamics; Hypotension; Male; Platelet Activating Factor; Prostaglandins; Thromboxane A2; Time Factors; Vasodilation; Veins | 1992 |
Increased thromboxane biosynthesis in type IIa hypercholesterolemia.
Topics: Adult; Aged; Anticholesteremic Agents; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Thromboxane A2 | 1992 |
Antiplatelet effects of 2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine in relation to its disposition in rats, rabbits and dogs.
Topics: Animals; Aspirin; Bridged Bicyclo Compounds; Dogs; Epoprostenol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicotinic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Thromboxane A2; Tissue Distribution | 1992 |
Platelet activation by cross-linking HLA class I molecules and Fc receptor.
Topics: Adenosine Diphosphate; Antibodies, Monoclonal; Apyrase; Aspirin; Blood Platelets; Calcium; Cross-Linking Reagents; Cytoplasmic Granules; Histocompatibility Antigens Class I; Humans; Hydrogen-Ion Concentration; Immunoglobulin G; Inositol 1,4,5-Trisphosphate; Phosphoproteins; Platelet Activation; Platelet Aggregation; Receptors, Fc; Thromboxane A2 | 1992 |
Low-dose-aspirin: treatment of the imbalance of increased thromboxane and decreased prostacyclin in preeclampsia.
Topics: Aspirin; Blood Platelets; Endothelium, Vascular; Epoprostenol; Female; Humans; Pre-Eclampsia; Pregnancy; Thromboxane A2 | 1992 |
Effect of calcium concentration and inhibitors on the responses of platelets stimulated with collagen: contrast between human and rabbit platelets.
Topics: Animals; Aspirin; Blood Platelets; Calcium; Cell Degranulation; Collagen; Cyclooxygenase Inhibitors; Cytosol; Humans; In Vitro Techniques; Indomethacin; Ketanserin; Kinetics; Rabbits; Thromboxane A2 | 1991 |
Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Aspirin; beta-Thromboglobulin; Blood Platelets; Collagen; Erythrocytes; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Membrane Glycoproteins; Serotonin; Thromboxane A2; Thromboxane B2; Thromboxanes | 1991 |
Rapidity and duration of platelet suppression by enteric-coated aspirin in healthy young men.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Epinephrine; Epoprostenol; Humans; Male; Platelet Aggregation; Reference Values; Tablets, Enteric-Coated; Thromboxane A2; Time Factors | 1992 |
[The level of vasoactive prostanoids in patients with ischemic heart disease in the early period following aortocoronary bypass].
Topics: Aspirin; Combined Modality Therapy; Coronary Artery Bypass; Coronary Disease; Dipyridamole; Drug Therapy, Combination; Epoprostenol; Humans; Phenindione; Postoperative Care; Postoperative Complications; Thromboxane A2; Time Factors | 1991 |
Thromboxane plasma level in kappa-carrageenin-induced acronecrosis of the tail in rats.
Topics: Animals; Aspirin; Carrageenan; Chlorpromazine; Dexamethasone; Heparin; Imidazoles; Naphthalenes; Necrosis; Pentanoic Acids; Pyridines; Radioimmunoassay; Rats; Rats, Inbred Strains; Thromboxane A2; Thromboxane B2 | 1991 |
Presystemic acetylation of platelets by aspirin: reduction in rate of drug delivery to improve biochemical selectivity for thromboxane A2.
Topics: Acetylation; Aspirin; Blood Platelets; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Delivery Systems; Duodenum; Humans; Intestinal Absorption; Liver; Male; Thromboxane A2; Thromboxane B2 | 1991 |
Role of internalization in platelet activation induced by collagen fibers--differential effects of aspirin, cytochalasin D, and prostaglandin E1.
Topics: Alprostadil; Aspirin; Biometry; Collagen; Cytochalasin D; Humans; Image Processing, Computer-Assisted; Microscopy, Electron; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Serotonin; Thromboxane A2 | 1991 |
[Characteristics of functional activity of thrombocytes in patients with "aspirin" bronchial asthma].
Topics: Aspirin; Asthma; Epoprostenol; Humans; In Vitro Techniques; Platelet Aggregation; Platelet Count; Platelet Function Tests; Stimulation, Chemical; Thromboxane A2 | 1991 |
Protective effects of the novel thromboxane A2 receptor antagonist sodium (E)-11-[2-(5,6-dimethyl-1-benzimidazolyl)-ethylidene]-6,11- dihydrodibenz[b,e]oxepine-2-carboxylate monohydrate against 9,11-dideoxy- 9 alpha, 11 alpha-epoxymethano-prostaglandin F2
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Benzimidazoles; Benzoxepins; Blood Pressure; Death, Sudden; Dose-Response Relationship, Drug; Guinea Pigs; Male; Phenylacetates; Platelet Aggregation Inhibitors; Platelet Count; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Sulfonamides; Thromboxane A2; Thromboxanes; Ticlopidine | 1991 |
Mechanisms of eicosanoid action.
Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Eicosanoids; Epoprostenol; Humans; Thromboxane A2 | 1991 |
Maximal blockade of TxA2 without compromised PGI2 formation; a superior profile of the TxA2 receptor blocking drug GR32191 over aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Biphenyl Compounds; Dose-Response Relationship, Drug; Epoprostenol; Heptanoic Acids; Humans; Male; Platelet Aggregation; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane B2 | 1991 |
Selective inhibition of platelet-derived thromboxane A2 in patients with lupus anticoagulant using low doses aspirin as assessed by enzyme immunoassay.
Topics: Aspirin; Autoantibodies; Blood Coagulation Factors; Blood Platelets; Humans; Immunoenzyme Techniques; Lupus Coagulation Inhibitor; Thromboxane A2 | 1991 |
Thromboxane-dependent platelet activation as a transducer of enhanced risk of coronary and cerebral thrombosis.
Topics: Aspirin; Coronary Thrombosis; Cross-Sectional Studies; Humans; Intracranial Embolism and Thrombosis; Platelet Activation; Risk Factors; Thromboxane A2; Thromboxane B2 | 1991 |
Pulmonary hypertension associated with long-standing thrombocytosis.
Topics: Adult; Aspirin; beta-Thromboglobulin; Fibrinopeptide A; Heparin; Humans; Hypertension, Pulmonary; Male; Platelet Activation; Splenectomy; Thalassemia; Thrombocytosis; Thromboxane A2; Time Factors | 1991 |
[Inhibitor of thromboxane A2 synthesis as anticoagulant in hemodialysis].
Topics: Animals; Aspirin; Blood Coagulation Disorders; Cyclooxygenase Inhibitors; Dogs; Fatty Acids, Monounsaturated; Humans; Methacrylates; Phospholipases; Receptors, Prostaglandin; Receptors, Thromboxane; Renal Dialysis; Sulfinpyrazone; Thromboxane A2; Thromboxane-A Synthase | 1991 |
Suppression of eicosanoid biosynthesis during coronary angioplasty by fish oil and aspirin.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Chest Pain; Eicosanoids; Epoprostenol; Fish Oils; Humans; Male; Patient Compliance; Thromboxane A2; Thromboxanes | 1991 |
Platelet hypersensitivity in cholesterol-fed rabbits: enhancement of thromboxane A2-dependent and thrombin-induced, thromboxane A2-independent platelet responses.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Cholesterol; Collagen; Hypercholesterolemia; Male; Platelet Aggregation; Platelet Count; Prostaglandin Endoperoxides, Synthetic; Rabbits; Serotonin; Thrombin; Thromboxane A2; Thromboxane B2 | 1991 |
Superoxide dismutase triggers activation of "primed" platelets.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Catalase; Collagen; Humans; Male; Platelet Activation; Platelet Aggregation; Serotonin; Superoxide Dismutase; Thromboxane A2 | 1991 |
Cyclooxygenase activity is increased in platelets from psoriatic patients.
Topics: Adult; Arachidonic Acid; Aspirin; Blood Platelets; Carbon Radioisotopes; Collagen; Humans; Kinetics; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Psoriasis; Thromboxane A2 | 1991 |
[Chronic arterial occlusive diseases--drug therapy and thromboxane A2 synthetase inhibitor].
Topics: Arterial Occlusive Diseases; Aspirin; Chronic Disease; Epoprostenol; Fatty Acids, Monounsaturated; Humans; Methacrylates; Polydeoxyribonucleotides; Pyridines; Thromboxane A2; Thromboxane-A Synthase | 1991 |
[Pathogenetic and therapeutic significance of the angioprotective systems in patients with coronary arteriosclerosis].
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Coronary Artery Disease; Depression, Chemical; Drug Therapy, Combination; Humans; Leukotriene B4; Male; Middle Aged; Quercetin; Stimulation, Chemical; Thromboxane A2 | 1990 |
Thromboxane A2 synthesis in pregnancy-induced hypertension.
Topics: Adolescent; Adult; Aspirin; Evaluation Studies as Topic; Female; Humans; Hypertension; Platelet Activation; Platelet Count; Pregnancy; Pregnancy Complications, Cardiovascular; Severity of Illness Index; Thromboxane A2; Thromboxane B2 | 1990 |
Endothelium-independent and endothelium-dependent contractions mediated by P2X- and P2Y-purinoceptors in canine basilar arteries.
Topics: Adenosine Triphosphate; Animals; Aspirin; Basilar Artery; Calcium; Dogs; Endothelium, Vascular; Female; Male; Methacrylates; Nifedipine; Receptors, Purinergic; Thromboxane A2; Vasoconstriction | 1991 |
Endothelium-independent and -dependent contractions induced by endothelin-1 in canine basilar arteries.
Topics: Animals; Arteries; Aspirin; Basilar Artery; Dogs; Endothelins; Endothelium; Female; In Vitro Techniques; Male; Methacrylates; Muscle Contraction; Muscle, Smooth, Vascular; Thromboxane A2; Time Factors; Vasoconstriction | 1991 |
Differential inhibition of thromboxane A2 and prostacyclin synthesis by low dose acetylsalicylic acid in atherosclerotic patients.
Topics: Aged; Aged, 80 and over; Arteriosclerosis; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Female; Humans; Male; Thromboxane A2 | 1990 |
Levamisole inhibits in vivo rat platelet aggregation by a release of prostacyclin-like factor.
Topics: Adenosine Diphosphate; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Epoprostenol; Half-Life; In Vitro Techniques; Leukocytes; Levamisole; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Thromboxane A2 | 1990 |
Inhibitory effects of endothelial cells and calcium channel blockers on platelet aggregation.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Aspirin; Blood Platelets; Bone Marrow Cells; Calcium Channel Blockers; Collagen; Diltiazem; Endothelium, Vascular; Epoprostenol; Fibroblasts; Humans; Nicardipine; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2; Verapamil | 1990 |
Inhibition of cyclooxygenase-independent platelet aggregation by low vitamin E concentration.
Topics: alpha-Tocopherol; Apyrase; Aspirin; Blood Platelets; Collagen; Epinephrine; Humans; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Tocopherols; Vitamin E | 1990 |
[Ischemic heart disease and prostanoids: pathogenesis and its implications for treatment].
Topics: Arachidonic Acids; Aspirin; Coronary Artery Disease; Coronary Disease; Coronary Vasospasm; Cyclooxygenase Inhibitors; Epoprostenol; Humans; Thromboxane A2 | 1990 |
Effects of various inhibitors on platelet activation induced by TP 82, a CD 9 monoclonal antibody.
Topics: Adenosine Diphosphate; Aequorin; Amino Acid Sequence; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Dose-Response Relationship, Drug; Humans; Membrane Glycoproteins; Molecular Sequence Data; Oligopeptides; Platelet Activation; Serotonin; Tetraspanin 29; Thromboxane A2 | 1990 |
Increased vasoconstrictor response to noradrenaline in femoral vascular bed of diabetic dogs. Is thromboxane A2 involved?
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Dogs; Dose-Response Relationship, Drug; Epoprostenol; Female; Femoral Vein; Indomethacin; Male; Norepinephrine; Organ Culture Techniques; Phentolamine; Thromboxane A2; Vasoconstriction | 1990 |
The effect of thromboxane receptor blockade versus thromboxane synthase inhibition on canine arterial graft patency.
Topics: Animals; Aspirin; Benzofurans; Bridged Bicyclo Compounds, Heterocyclic; Dipyridamole; Dogs; Fatty Acids, Unsaturated; Graft Occlusion, Vascular; Hydrazines; Male; Platelet Aggregation; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase; Vascular Patency | 1990 |
Combined thromboxane A2 synthetase inhibition and receptor blockade are effective in preventing spontaneous and epinephrine-induced canine coronary cyclic flow variations.
Topics: Animals; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Coronary Circulation; Coronary Disease; Dogs; Epinephrine; Epoprostenol; Ergolines; Fatty Acids, Unsaturated; Female; Hydrazines; Imidazoles; Male; Pentanoic Acids; Pyridines; Receptors, Prostaglandin; Receptors, Thromboxane; Serotonin Antagonists; Thromboxane A2; Thromboxane-A Synthase | 1990 |
Platelet thromboxane A2/prostaglandin H2 receptors in human volunteers on low doses of aspirin.
Topics: Adult; Aspirin; Blood Platelets; Female; Humans; Male; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thrombin; Thromboxane A2; Thromboxane B2 | 1990 |
Bradykinin-induced vasoconstriction of rat mesenteric arteries precontracted with noradrenaline.
Topics: Animals; Aspirin; Bradykinin; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase Inhibitors; Eicosanoids; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Imidazoles; In Vitro Techniques; Indomethacin; Meclofenamic Acid; Mesenteric Arteries; Norepinephrine; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction | 1990 |
Proaggregatory effect of epinephrine on rabbit platelets inhibited by ticlopidine.
Topics: Adenosine Diphosphate; Amiloride; Animals; Aspirin; Drug Interactions; Epinephrine; Hydrogen-Ion Concentration; Male; Methylamines; Monensin; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Receptors, Adrenergic, alpha; Sodium; Thromboxane A2; Ticlopidine | 1990 |
Inositol phospholipid metabolism in human platelets stimulated by ADP.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Calcium; Fibrinogen; Humans; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Platelet Aggregation; Thromboxane A2; Type C Phospholipases | 1990 |
[Effect of low-dose aspirin therapy on utero-placental blood flow and malondialdehyde (MDA) as an indicator of its therapeutic effect].
Topics: Adult; Aspirin; Epoprostenol; Female; Fetal Growth Retardation; Humans; Malondialdehyde; Middle Aged; Placenta; Pre-Eclampsia; Pregnancy; Regional Blood Flow; Thromboxane A2; Uterus | 1990 |
Pathogenetic components of acute ischemic syndromes. Focus on acute ischemic stimuli.
Topics: Aspirin; Coronary Artery Disease; Coronary Disease; Coronary Thrombosis; Humans; Thromboxane A2 | 1990 |
Modifications by endogenous prostaglandins of angiotensin II-induced contractions in dog and monkey cerebral and mesenteric arteries.
Topics: Angiotensin II; Animals; Aspirin; Cerebral Arteries; Dogs; Female; In Vitro Techniques; Indomethacin; Macaca; Male; Mesenteric Arteries; Prostaglandins; Thromboxane A2; Vasoconstriction | 1990 |
Stimulus-response coupling in human platelets activated by monoclonal antibodies to the CD9 antigen, a 24 kDa surface-membrane glycoprotein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Aspirin; Blood Platelets; Calcium; Collagen; Humans; Hydrogen-Ion Concentration; Immunoglobulin Fab Fragments; Isoquinolines; Membrane Glycoproteins; Phosphoproteins; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Kinase C; Serotonin; Signal Transduction; Tetraspanin 29; Thromboxane A2 | 1990 |
Differences in bleeding time, aspirin sensitivity and adrenaline between acute myocardial infarction and unstable angina.
Topics: Aged; Angina Pectoris; Angina, Unstable; Aspirin; Bleeding Time; Blood Platelets; Chest Pain; Epinephrine; Female; Humans; Male; Middle Aged; Myocardial Infarction; Norepinephrine; Thromboxane A2 | 1990 |
The prominent role of thromboxane A2 formation on early pulmonary hypertension induced by oleic acid administration in sheep.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Platelets; Blood Pressure; Disease Models, Animal; Hypertension, Pulmonary; Leukocytes; Oleic Acid; Oleic Acids; Sheep; Thromboxane A2; Vascular Resistance | 1990 |
Thromboxane biosynthesis and platelet function in type II diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Thromboxanes | 1990 |
An endothelium-dependent contraction induced by A-23187, a Ca++ ionophore in canine basilar artery.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aspirin; Basilar Artery; Calcimycin; Dogs; Endothelium, Vascular; Female; Male; Methacrylates; Nifedipine; Quinacrine; Thromboxane A2; Vasoconstriction | 1988 |
Role of serotonin, histamine, and thromboxane A2 in platelet-induced contractions of coronary arteries and aortae from rabbits.
Topics: Animals; Aorta, Thoracic; Aspirin; Blood Platelets; Coronary Vessels; Diphenhydramine; Endothelium, Vascular; Female; Histamine; In Vitro Techniques; Isometric Contraction; Ketanserin; Male; Methysergide; Muscle Contraction; Muscle, Smooth, Vascular; Phentolamine; Rabbits; Serotonin; Thromboxane A2 | 1989 |
Iron chelators inhibit human platelet aggregation, thromboxane A2 synthesis and lipoxygenase activity.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Deferiprone; Deferoxamine; Epinephrine; Humans; Iron; Iron Chelating Agents; Lipoxygenase; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyridones; Thromboxane A2 | 1989 |
Inhibition of cyclooxygenase-independent platelet aggregation by sodium salicylate.
Topics: Adult; Aspirin; Epinephrine; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Sodium Salicylate; Thromboxane A2 | 1989 |
[Treatment of chronic proliferative glomerulonephritis using acetylsalicylic acid and dipyridamole].
Topics: Adult; Aspirin; Chronic Disease; Dipyridamole; Drug Therapy, Combination; Epoprostenol; Female; Glomerulonephritis, Membranoproliferative; Humans; Male; Platelet Aggregation; Thromboxane A2 | 1989 |
Thromboxane A2 and prostacyclin generation in the microvasculature of patients with atherosclerosis--effect of low-dose aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Arteriosclerosis; Aspirin; Bleeding Time; Blood Platelets; Drug Administration Schedule; Endothelium, Vascular; Epoprostenol; Female; Humans; Male; Microcirculation; Middle Aged; Thromboxane A2; Thromboxane B2 | 1989 |
Platelet and vascular function during coronary thrombolysis with tissue-type plasminogen activator.
Topics: Adult; Aged; Aspirin; Epoprostenol; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Platelet Activation; Thrombolytic Therapy; Thromboxane A2; Tissue Plasminogen Activator | 1989 |
Increased platelet aggregation and intracellular calcium in hypertensive patients: effects of cyclo-oxygenase blockade.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcium; Cyclooxygenase Inhibitors; Female; Humans; Hypertension; Male; Middle Aged; Platelet Aggregation; Thromboxane A2 | 1989 |
Effect of the thromboxane A2 receptor antagonist SQ 30,741 on ultimate myocardial infarct size, reperfusion injury and coronary flow reserve.
Topics: Adenosine; Animals; Aspirin; Coronary Circulation; Dogs; Female; Male; Myocardial Infarction; Receptors, Prostaglandin; Receptors, Thromboxane; Reperfusion Injury; Thromboxane A2 | 1989 |
Effect of a novel thromboxane A2 receptor antagonist, S-145, on collagen-induced ECG changes and thrombocytopenia in rodents.
Topics: Administration, Oral; Animals; Aspirin; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Collagen; Electrocardiography; Fatty Acids, Monounsaturated; Imidazoles; In Vitro Techniques; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Prostaglandins; Rats; Receptors, Prostaglandin; Receptors, Thromboxane; Thrombocytopenia; Thromboxane A2 | 1989 |
Effects of ethanol on human platelets stimulated with platelet-activating factor, a biologically active ether phospholipid.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Blood Platelets; Ethanol; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides, Synthetic; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Prostaglandin; Receptors, Thromboxane; Serotonin; Thromboxane A2 | 1989 |
Effect of acetyl salicylic acid on increased production of thromboxane after aortic graft surgery.
Topics: Aged; Aorta, Abdominal; Aortic Aneurysm; Aortic Diseases; Arterial Occlusive Diseases; Aspirin; Blood Vessel Prosthesis; Epoprostenol; Female; Humans; Male; Thromboxane A2 | 1989 |
Thromboxane production in placentas of women with preeclampsia.
Topics: Aspirin; Female; Humans; Placenta; Pre-Eclampsia; Pregnancy; Thromboxane A2; Thromboxanes | 1989 |
Failure of aspirin to impair bovine platelet function.
Topics: Animals; Aspirin; Blood Platelets; Cattle; Female; Platelet Aggregation; Thromboxane A2; Time Factors | 1989 |
Aspirin and pre-eclampsia.
Topics: Aspirin; Blood Platelets; Female; Humans; Placenta; Pre-Eclampsia; Pregnancy; Thromboxane A2 | 1986 |
Endothelium-dependent contraction induced by nicotine in isolated canine basilar artery--possible involvement of a thromboxane A2 (TXA2) like substance.
Topics: Animals; Aspirin; Atropine; Basilar Artery; Dogs; Endothelium, Vascular; Female; Hexamethonium; Hexamethonium Compounds; Male; Methacrylates; Microscopy, Electron, Scanning; Muscle Contraction; Muscle, Smooth, Vascular; Nicotine; Phentolamine; Physostigmine; Serotonin; Thromboxane A2; Thromboxane-A Synthase | 1988 |
The effects of thromboxane antagonism on the transit time of platelets through the spleen.
Topics: Aged; Aspirin; Biphenyl Compounds; Blood Circulation; Blood Platelets; Dipyridamole; Double-Blind Method; Humans; Kinetics; Middle Aged; Platelet Aggregation; Random Allocation; Receptors, Prostaglandin; Receptors, Thromboxane; Spleen; Thromboxane A2 | 1985 |
In vivo formation of prostacyclin and thromboxane A2 at the site of platelet-vascular interaction in humans.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Bleeding Time; Blood Platelets; Blood Vessels; Epoprostenol; Female; Humans; Male; Thromboxane A2; Thromboxane B2 | 1987 |
High concentrations of arachidonic acid induce platelet aggregation and serotonin release independent of prostaglandin endoperoxides and thromboxane A2.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Albumins; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Bucladesine; Culture Media; Diglycerides; Dose-Response Relationship, Drug; Edetic Acid; Fatty Acids; Fatty Acids, Unsaturated; Humans; Molecular Weight; Phosphatidic Acids; Phosphocreatine; Phosphorylation; Platelet Aggregation; Prostaglandin Endoperoxides; Secretory Rate; Serotonin; Thromboxane A2 | 1985 |
The response of human carcinoma cell lines to gamma-linolenic acid with special reference to the effects of agents which influence prostaglandin and thromboxane synthesis.
Topics: Alprostadil; Aspirin; Cell Division; Cell Line; Cell Survival; gamma-Linolenic Acid; Humans; Imidazoles; Indomethacin; Linolenic Acids; Neoplasms; Prostaglandins; Prostaglandins E; Thromboxane A2; Thromboxanes | 1985 |
Modes of action of aspirin-like drugs.
Topics: Anti-Inflammatory Agents; Aspirin; Blood Platelets; Calcium; Cell Aggregation; Complement C5; Cyclic AMP; Cyclooxygenase Inhibitors; Indomethacin; Leukotriene B4; Lymphocyte Activation; Neutrophils; Piroxicam; Prostaglandin Antagonists; Salicylates; Superoxides; Thiazines; Thromboxane A2 | 1985 |
Leukotrienes potentiate the effects of epinephrine and thrombin on human platelet aggregation.
Topics: Aspirin; Calcium; Drug Synergism; Epinephrine; Humans; Leukotriene E4; Methacrylates; Platelet Aggregation; SRS-A; Thrombin; Thromboxane A2; Time Factors | 1986 |
Inhibition of platelet thromboxane generation by suloctidil in man.
Topics: Adult; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Dinoprostone; Drug Interactions; Epoprostenol; Female; Humans; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Propanolamines; Prostaglandins E; Rats; Suloctidil; Thromboxane A2; Thromboxane B2 | 1986 |
Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Carrier Proteins; Enzyme Activation; Epinephrine; Fibrinogen; Humans; Hydrogen-Ion Concentration; Phospholipases; Phospholipases A; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Sodium-Hydrogen Exchangers; Thromboxane A2; Type C Phospholipases | 1986 |
Comparison of the inhibitory effects of aspirin and ticlopidine on platelet aggregation and Ca2+ mobilization in rat platelets.
Topics: Animals; Anticoagulants; Aspirin; Blood Platelets; Calcium; Cyclic AMP; Female; Male; Malondialdehyde; Platelet Aggregation; Rats; Rats, Inbred Strains; Sex Factors; Thromboxane A2; Ticlopidine | 1986 |
Pharmacological management of an impending placental insufficiency.
Topics: Aspirin; Epoprostenol; Female; Gestational Age; Humans; Microcirculation; Placenta Diseases; Placental Insufficiency; Pregnancy; Thromboxane A2; Trapidil; Ultrasonics | 1988 |
Effects of Gramoxone-induced reactive oxygen radicals on eicosanoid synthesis of mouse lung.
Topics: Animals; Aspirin; Epoprostenol; Female; Free Radicals; Lethal Dose 50; Lipid Peroxidation; Lung; Male; Mice; Oxygen; Paraquat; Superoxide Dismutase; Thromboxane A2; Thromboxane B2 | 1988 |
Altered renal and platelet arachidonic acid metabolism in cirrhosis.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Kidney Injury; Adult; Aged; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Creatinine; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Epoprostenol; Female; Humans; Kidney; Liver Cirrhosis; Male; Middle Aged; Natriuresis; Prostaglandins E; Prostaglandins F; Renin-Angiotensin System; Sulindac; Thromboxane A2; Thromboxane B2 | 1986 |
The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation in man and the rat.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Creatine Kinase; Dose-Response Relationship, Drug; Humans; Imidazoles; In Vitro Techniques; Male; Phosphocreatine; Platelet Aggregation; Prostaglandin Endoperoxides; Rats; Rats, Inbred Strains; Species Specificity; Thromboxane A2; Thromboxane B2 | 1986 |
Regulation of thromboxane A2 biosynthesis in platelet-free human monocytes and the possible role of polypeptide growth factor(s) in the induction of cyclooxygenase system.
Topics: ABO Blood-Group System; Animals; Aspirin; Blood; Cattle; Dactinomycin; Dinoprostone; Enzyme Induction; Humans; Hydrogen-Ion Concentration; Indomethacin; Kinetics; Monocytes; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Thromboxane A2; Thromboxane B2 | 1986 |
Sex difference in the effect of aspirin on intracellular Ca2+ mobilization and thromboxane A2 production in rat platelets.
Topics: Animals; Aspirin; Blood Platelets; Calcium; Castration; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Sex Factors; Testosterone; Thrombin; Thromboxane A2 | 1986 |
Slow intravenous administration of low dose aspirin inhibits both vascular and platelet cyclooxygenase activity: an experimental study in the rat.
Topics: Animals; Aspirin; Blood Platelets; Blood Vessels; Cyclooxygenase Inhibitors; Epoprostenol; Injections, Intravenous; Male; Rats; Thromboxane A2 | 1986 |
Low-dose enteric-coated aspirin: a practical approach to continuous-release low-dose aspirin and presystemic acetylation of human platelet cyclooxygenase.
Topics: Acetylation; Aspirin; Bleeding Time; Blood Platelets; Drug Administration Schedule; Humans; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Tablets, Enteric-Coated; Thromboxane A2; Thromboxane B2 | 1986 |
Aspirin prolongs bleeding time in uremia by a mechanism distinct from platelet cyclooxygenase inhibition.
Topics: Acetylation; Adult; Aged; Aspirin; Bleeding Time; Blood Platelets; Cyclooxygenase Inhibitors; Female; Hemorrhagic Disorders; Humans; Ibuprofen; Kinetics; Male; Middle Aged; Platelet Function Tests; Thromboxane A2; Uremia | 1987 |
Effect of single-dose aspirin on TXA2 and PGI2 cyclooxygenases in vivo.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Dose-Response Relationship, Drug; Epoprostenol; Mice; Osmolar Concentration; Prostaglandin-Endoperoxide Synthases; Thromboxane A2 | 1987 |
Altered intraplatelet arachidonic acid metabolism during the acute state of unstable angina.
Topics: Acute Disease; Angina Pectoris; Angina, Unstable; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Female; Humans; In Vitro Techniques; Male; Middle Aged; Thromboxane A2 | 1987 |
Plasma thromboxane and prostacyclin metabolite ratio in atherosclerosis and diabetes mellitus.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arteriosclerosis; Aspirin; Diabetes Mellitus; Epoprostenol; Female; Humans; Male; Middle Aged; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Thromboxane B2 | 1987 |
Eicosanoids and aspirin-sensitive asthma.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Blood Platelets; Humans; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Thromboxane A2; Thromboxanes | 1987 |
Exchange of cyclooxygenase dependent metabolites between vessel wall and platelets in arterial thrombosis.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Epoprostenol; Imidazoles; Male; Mesenteric Arteries; Platelet Aggregation; Propionates; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Thrombosis; Thromboxane A2; Tranylcypromine | 1988 |
Studies on the effect of long-term use of low dose aspirin in Kawasaki disease.
Topics: Adenosine Diphosphate; Aspirin; Child, Preschool; Collagen; Dose-Response Relationship, Drug; Epinephrine; Epoprostenol; Female; Humans; Male; Mucocutaneous Lymph Node Syndrome; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins; Prostaglandins F; Thromboxane A2; Thromboxane B2; Time Factors | 1988 |
Acetyl glycerylphosphorylcholine aggregates human platelets through two distinct pathways, both dependent on arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Catechols; Chromatography, Thin Layer; Cyclooxygenase Inhibitors; Humans; Imidazoles; In Vitro Techniques; Lipoxygenase Inhibitors; Masoprocol; Phospholipases; Platelet Activating Factor; Platelet Aggregation; Prostanoic Acids; Quinacrine; Radioimmunoassay; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase | 1985 |
Effects of the prostaglandin H2/thromboxane A2 antagonist BM 13.177 on human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Blood Platelets; Collagen; Humans; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Serotonin; Sulfonamides; Thrombin; Thromboxane A2; Thromboxanes | 1985 |
Pharmacokinetics of low-dose oral modified release, soluble and intravenous aspirin in man, and effects on platelet function.
Topics: Administration, Oral; Adult; Aspirin; Female; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Platelet Aggregation; Salicylates; Salicylic Acid; Thromboxane A2 | 1988 |
Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction.
Topics: Aspirin; Blood Platelets; Epoprostenol; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Streptokinase; Thromboxane A2 | 1988 |
Pharmacokinetics of enteric-coated aspirin and inhibition of platelet thromboxane A2 and vascular prostacyclin generation in humans.
Topics: Adult; Aspirin; Blood Platelets; Epoprostenol; Female; Humans; Kinetics; Salicylates; Salicylic Acid; Saphenous Vein; Tablets, Enteric-Coated; Thromboxane A2; Thromboxane B2 | 1987 |
The enigma of aspirin.
Topics: Aspirin; Dose-Response Relationship, Drug; Epoprostenol; Humans; Platelet Aggregation; Thromboembolism; Thromboxane A2 | 1987 |
[Effects of low-dose aspirin on platelet aggregation and the biosynthesis of PGI2 and TXA2 in patients with coronary heart disease].
Topics: Aspirin; Coronary Disease; Epoprostenol; Female; Humans; Male; Middle Aged; Platelet Aggregation; Thromboxane A2 | 1987 |
Effect of 50 mg enteric-coated aspirin (Astrix) on thromboxane and prostacyclin synthesis.
Topics: Aspirin; Delayed-Action Preparations; Epoprostenol; Fibrinolytic Agents; Humans; Thromboxane A2 | 1987 |
Inhibition by picotamide of thromboxane production in vitro and ex vivo.
Topics: Adult; Aspirin; Blood Platelets; Female; Humans; In Vitro Techniques; Male; Phthalic Acids; Platelet Aggregation; Prostaglandins; Thromboxane A2; Thromboxane-A Synthase | 1988 |
Primary thrombocythaemia in childhood: symptomatic episodes and their relationship to thromboxane A2, 6-keto-PGE1 and 12-hydroxy-eicosatetraenoic acid production: a case report.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 6-Ketoprostaglandin F1 alpha; Alprostadil; Arachidonate 12-Lipoxygenase; Aspirin; Asthma; Blood Platelets; Child; Eosinophilia; Humans; Hydroxyeicosatetraenoic Acids; Male; Platelet Aggregation; Thrombocytosis; Thromboxane A2 | 1987 |
[Acute pulmonary failure in acetylsalicylic acid poisoning].
Topics: Adult; Aspirin; Dinoprost; Female; Humans; Middle Aged; Prostaglandins F; Pulmonary Alveoli; Respiration, Artificial; Respiratory Insufficiency; Thromboxane A2 | 1987 |
The effect of predetermined thrombotic potential of the recipient on small-caliber graft performance.
Topics: Animals; Aspirin; Blood Cell Count; Blood Vessel Prosthesis; Carotid Arteries; Dogs; Drug Therapy, Combination; Epoprostenol; Graft Occlusion, Vascular; Imidazoles; Male; Malondialdehyde; Platelet Aggregation; Prostaglandins; Thrombosis; Thromboxane A2; Thromboxane-A Synthase | 1986 |
Reductive effect of aspirin treatment on primary tumor growth and metastasis of implanted fibrosarcoma in rats.
Topics: Animals; Aspirin; Epoprostenol; Female; Fibrosarcoma; Neoplasm Metastasis; Neoplasm Transplantation; Platelet Aggregation; Prostaglandins; Rats; Rats, Inbred BN; Theophylline; Thromboxane A2 | 1986 |
Maternal ingestion of acetylsalicylic acid inhibits fetal and neonatal prostacyclin and thromboxane in humans.
Topics: Adult; Aspirin; Epoprostenol; Female; Fetal Blood; Humans; Infant, Newborn; Pregnancy; Thromboxane A2; Thromboxane B2; Thromboxanes | 1986 |
Oral acetylsalicylic acid improves patency rates in small-vessel anastomoses.
Topics: Administration, Oral; Animals; Aspirin; Femoral Artery; Male; Platelet Aggregation; Postoperative Complications; Rats; Rats, Inbred Strains; Suture Techniques; Thrombosis; Thromboxane A2; Vascular Patency | 1986 |
Why a little aspirin is better than a lot.
Topics: Aspirin; Dose-Response Relationship, Drug; Epoprostenol; Thromboxane A2 | 1987 |
Increased thromboxane B2 excretion in diabetes mellitus.
Topics: Adult; Aspirin; Blood Platelets; Diabetes Mellitus; Female; Glomerular Filtration Rate; Humans; Kidney; Male; p-Aminohippuric Acid; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1987 |
Endothelium-dependent vasocontraction in response to noradrenaline in the canine cerebral artery.
Topics: Animals; Aspirin; Cerebral Arteries; Dogs; Endothelium; Female; In Vitro Techniques; Male; Methacrylates; Norepinephrine; Prazosin; Serotonin; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction; Yohimbine | 1987 |
Spontaneous platelet aggregation: observations on potential mechanisms.
Topics: Adult; Apyrase; Aspirin; Blood Platelet Disorders; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; In Vitro Techniques; Methacrylates; Platelet Aggregation; Thromboxane A2; Yohimbine | 1987 |
Inhibition of platelet 5-HT secretion and of 5-HT induced vasoconstriction by paracetamol.
Topics: Acetaminophen; Adenosine Diphosphate; Aspirin; Blood Platelets; Humans; In Vitro Techniques; Platelet Aggregation; Salicylates; Salicylic Acid; Serotonin; Thromboxane A2; Vasoconstriction | 1987 |
Effects of inhibition of thromboxane A2 synthesis in aspirin-induced asthma.
Topics: Acrylates; Adult; Aspirin; Asthma; Female; Humans; Male; Methacrylates; Middle Aged; Respiratory Function Tests; Thromboxane A2 | 1987 |
Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs.
Topics: Adult; Aspirin; Blood Platelets; Humans; Imidazoles; Male; Metabolic Clearance Rate; Middle Aged; Platelet Count; Salicylates; Thromboxane A2; Thromboxane B2 | 1987 |
Effects of oral diltiazem on platelet function: alone and in combination with "low dose" aspirin.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Administration, Oral; Aspirin; Bleeding Time; Blood Platelets; Diltiazem; Epinephrine; Humans; Male; Platelet Aggregation; Thromboxane A2 | 1986 |
Sex-related differences in the effects of aspirin on the interaction of platelets with subendothelium.
Topics: Administration, Oral; Adult; Aspirin; Blood Platelets; Blood Vessels; Endothelium; Female; Humans; Male; Platelet Adhesiveness; Platelet Aggregation; Sex Factors; Thrombosis; Thromboxane A2 | 1986 |
Mouse antithrombotic assay: the effects of Ca++ channel blockers are platelet-independent.
Topics: Animals; Aspirin; Blood Platelets; Calcium Channel Blockers; Collagen; Death, Sudden; Epinephrine; Erythrocytes; Fibrinolytic Agents; Mice; Platelet Aggregation; Platelet Count; Platelet Factor 4; Thromboxane A2 | 1987 |
Cumulative inhibitory effect of low-dose aspirin on vascular prostacyclin and platelet thromboxane production in patients with atherosclerosis.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Blood Platelets; Blood Vessels; Coronary Disease; Epoprostenol; Humans; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxanes | 1985 |
[Effects of sodium ferulate combined with acetylsalicylic acid on rat platelet aggregation and on modulation of PGI2-TXA2 balance].
Topics: Animals; Anticoagulants; Aspirin; Cinnamates; Coumaric Acids; Drug Synergism; Epoprostenol; Male; Platelet Aggregation; Rabbits; Rats; Thromboxane A2; Thromboxanes | 1985 |
Differential inhibition of platelet thromboxane and lung prostacyclin production by sulphinpyrazone, acetylsalicylic acid and indomethacin by human tissues in vitro.
Topics: 6-Ketoprostaglandin F1 alpha; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Epoprostenol; Humans; In Vitro Techniques; Indomethacin; Lung; Sulfinpyrazone; Thromboxane A2; Thromboxane B2 | 1985 |
Differential effects of aspirin and indomethacin on platelet and leukocyte thromboxane A2 formation.
Topics: Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Indomethacin; Leukocytes; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Thromboxanes | 1985 |
Platelet aggregation in whole blood: the role of thromboxane A2 and adenosine diphosphate.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenosine Diphosphate; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Cyclooxygenase Inhibitors; Epinephrine; Flurbiprofen; Humans; Imidazoles; In Vitro Techniques; Lipoxygenase Inhibitors; Platelet Aggregation; Pyrazoles; Thrombin; Thromboxane A2; Thromboxane-A Synthase | 1985 |
Selective inhibition of thromboxane-related platelet function by low-dose aspirin in patients after myocardial infarction.
Topics: Aged; Aspirin; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Thromboxane A2; Thromboxanes | 1985 |
[Arachidonic acids].
Topics: Arachidonic Acids; Aspirin; Blood Platelets; Diabetes Mellitus; Humans; Methods; Myeloproliferative Disorders; Thromboxane A2 | 1985 |
Impaired arteriolar vasodilation induced by thrombosis of a coronary arterial stenosis.
Topics: Animals; Arterial Occlusive Diseases; Aspirin; Coronary Circulation; Heart Rate; Hemodynamics; Imidazoles; Lactates; Lactic Acid; Prostaglandin Endoperoxides, Synthetic; Regional Blood Flow; Swine; Thrombosis; Thromboxane A2; Vascular Resistance; Vasodilation | 1985 |
Anti-thrombotic effect of curcumin.
Topics: Animals; Aspirin; Blood Platelets; Catechols; Collagen; Curcumin; Epinephrine; Macaca mulatta; Male; Malondialdehyde; Mice; Thrombosis; Thromboxane A2 | 1985 |
Congenital deficiency of thromboxane and prostacyclin.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Blood Coagulation Tests; Blood Platelet Disorders; Cells, Cultured; Chromatography, Thin Layer; Epoprostenol; Hemorrhage; Humans; Male; Oxygenases; Plasma; Platelet Aggregation; Prostaglandins; Thromboxane A2; Thromboxanes | 1980 |
Thromboxane A2 in skin-bleeding-time blood and in clotted venous blood before and after administration of acetylsalicylic acid.
Topics: Adenosine Diphosphate; Adult; Aspirin; Bleeding Time; England; Hemorrhage; Hemostasis; Humans; Male; Platelet Aggregation; Platelet Function Tests; Skin; Sweden; Thromboxane A2; Thromboxane B2; Thromboxanes | 1983 |
Biological activity of leukotriene C4 in guinea pigs: in vitro and in vivo studies.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Pressure; Bradykinin; Epoprostenol; Guinea Pigs; Histamine; Indomethacin; Lung; Male; Muscle Contraction; SRS-A; Thromboxane A2; Trachea | 1982 |
Pharmacological studies on OKY-1581: a selective thromboxane synthetase inhibitor.
Topics: Acrylates; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Biological Assay; Blood Platelets; Cerebral Infarction; Haplorhini; Kinetics; Methacrylates; Muscle Contraction; Oxidoreductases; Platelet Aggregation; Rabbits; Rats; Thrombosis; Thromboxane A2; Thromboxane-A Synthase | 1983 |
Prostaglandins and angioplasty. An experimental study in canine arteries.
Topics: Angioplasty, Balloon; Animals; Aspirin; Carotid Arteries; Cyclooxygenase Inhibitors; Dogs; Epoprostenol; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Platelet Aggregation; Thromboxane A2; Thromboxanes | 1983 |
[Therapy of peripheral arterial occlusive diseases. Round table conference].
Topics: Alprostadil; Angioplasty, Balloon; Anti-Bacterial Agents; Anticoagulants; Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Dipyridamole; Endarterectomy; Exercise Therapy; Fibrinolysis; Humans; Hyperlipidemias; Hypertension; Infusions, Intra-Arterial; Intermittent Claudication; Prostaglandins E; Serotonin Antagonists; Sympathectomy; Thromboxane A2 | 1983 |
Aspirin therapy in small-caliber arterial prostheses: long-term experimental observations.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Antigens; Aspirin; Blood Platelets; Blood Vessel Prosthesis; Dogs; Epoprostenol; Factor VIII; Malondialdehyde; Platelet Aggregation; Polyethylene Terephthalates; Thromboxane A2; Thromboxane B2; Time Factors; von Willebrand Factor | 1984 |
Effects of AVS (1,2-bis(nicotinamido)propane) on platelet function and vascular endothelium.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Blood Vessels; Cerebrovascular Disorders; Collagen; Dinoprostone; Endothelium; In Vitro Techniques; Mice; Microscopy, Electron, Scanning; Niacinamide; Platelet Aggregation; Prostaglandins E; Rabbits; Rats; Rats, Inbred Strains; Thromboembolism; Thrombosis; Thromboxane A2 | 1984 |
[Prevention of thrombosis by thrombocyte inhibitors. 1. Cell regulation mechanisms and pharmacological modification].
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Cyclic AMP; Dextrans; Dipyridamole; Humans; Hydroxychloroquine; Indomethacin; Platelet Aggregation; Prostaglandins; Sulfinpyrazone; Thrombosis; Thromboxane A2 | 1980 |
Interrelationships between prostacyclin and thromboxane A2.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Platelets; Cardiovascular Physiological Phenomena; Cardiovascular System; Cyclic AMP; Epoprostenol; Heart; Humans; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandins; Pulmonary Circulation; Thromboxane A2; Thromboxanes; Vasodilation | 1980 |
Prostacyclin-thromboxane interactions in the platelet-perfused in vitro heart.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Platelets; Blood Pressure; Cyclic AMP; Epoprostenol; Female; Guinea Pigs; Heart; Humans; In Vitro Techniques; Kinetics; Male; Perfusion; Prostaglandins; Thromboxane A2; Thromboxanes | 1981 |
Platelet aggregation and thromboxane A2 production after adrenergic stimulation in young healthy humans.
Topics: Adolescent; Adult; Aspirin; beta-Thromboglobulin; Cold Temperature; Female; Humans; Male; Platelet Aggregation; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Thromboxane A2; Thromboxane B2; Thromboxanes; Vascular Resistance | 1982 |
Evidence for a mediator role of thromboxane A2 in the myotropic action of leukotriene B4 (LTB4) on the guinea-pig lung.
Topics: Animals; Arachidonic Acids; Aspirin; Female; Flufenamic Acid; Guinea Pigs; Imidazoles; Indoles; Leukotriene B4; Leukotrienes; Lipid Peroxides; Lung; Male; Muscle Contraction; Peroxides; Prostaglandins; Pyridines; Quinacrine; Thromboxane A2; Thromboxane B2; Thromboxanes | 1982 |
Differential inhibition by aspirin of vascular and platelet prostaglandin synthesis in atherosclerotic patients.
Topics: Administration, Oral; Aged; Arteries; Arteriosclerosis; Aspirin; Blood Platelets; Blood Vessels; Culture Techniques; Epoprostenol; Female; Humans; Male; Middle Aged; Platelet Aggregation; Prostaglandins; Thromboxane A2; Veins | 1983 |
[Surveillance of treatment with antiaggregating agents].
Topics: Aspirin; Blood Coagulation Tests; Dipyridamole; Epoprostenol; Humans; Platelet Aggregation; Prostaglandins; Thromboxane A2; Thromboxanes | 1983 |
The stimulatory effect of prostacyclin (PGI2) on isolated rabbit and rat aorta is probably associated to the generation of a thromboxane A2 (TXA2) "like-material".
Topics: Adenosine Diphosphate; Animals; Aorta, Thoracic; Aspirin; Corticosterone; Epoprostenol; Imidazoles; In Vitro Techniques; Indomethacin; Male; Prostaglandins; Rabbits; Rats; Species Specificity; Thromboxane A2; Thromboxanes; Vasoconstriction | 1983 |
Aspirin as an antithrombotic medication.
Topics: Arachidonic Acids; Aspirin; Epoprostenol; Humans; Platelet Aggregation; Postoperative Complications; Thrombophlebitis; Thromboxane A2 | 1983 |
[Blood thromboxane A2 and prostaglandin I2 levels and platelet phospholipid fatty acid composition ratios in ischemic heart disease and cerebral infarction--with special reference to the effect of antiplatelet agents].
Topics: Aged; Aspirin; Blood Platelets; Cerebral Infarction; Coronary Disease; Dipyridamole; Epoprostenol; Fatty Acids; Female; Humans; Male; Middle Aged; Phospholipids; Thromboxane A2; Thromboxanes; Trapidil | 1983 |
Selective and nonselective inhibition of thromboxane formation.
Topics: Aspirin; Blood Platelets; Collagen; Epoprostenol; Humans; Imidazoles; Male; Pyridines; Random Allocation; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1984 |
MI: recent insights--and new treatments?
Topics: Animals; Aspirin; Coronary Disease; Diet; Dogs; Epoprostenol; Humans; Male; Platelet Aggregation; Risk; Thromboxane A2 | 1984 |
The aspirin dilemma revisited.
Topics: Aspirin; Epoprostenol; Humans; Thrombosis; Thromboxane A2 | 1984 |
Platelet function and biosynthesis of prostacyclin and thromboxane A2 in whole blood after aspirin administration in human subjects.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Triphosphate; Adult; Aspirin; Blood Platelets; Epoprostenol; Female; Humans; Male; Platelet Aggregation; Thromboxane A2; Thromboxanes | 1984 |
Prostaglandins and vascular function.
Topics: Aspirin; Blood Platelets; Blood Vessels; Cardiovascular Diseases; Diet; Epoprostenol; Hemostasis; Humans; Platelet Aggregation; Prostaglandins; Prostaglandins E; Thromboxane A2; Vascular Diseases | 1984 |
Conversion from chronic to acute coronary artery disease: speculation regarding mechanisms.
Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Angina, Unstable; Aorta; Aspirin; Blood Pressure; Coronary Circulation; Coronary Disease; Coronary Vessels; Epoprostenol; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Prostaglandins; Thromboxane A2; Thromboxane B2 | 1984 |
Inhibition of platelet aggregation by a new agent, 2,2'-dithiobis-(N-2-hydroxypropyl benzamide) (KF4939).
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Benzamides; Collagen; Dose-Response Relationship, Drug; Fibrinolytic Agents; Humans; In Vitro Techniques; Male; Mice; Papaverine; Platelet Aggregation; Rabbits; Rats; Rats, Inbred Strains; Thrombin; Thrombocytopenia; Thrombosis; Thromboxane A2 | 1983 |
Human vascular tissues produce thromboxane as well as prostacyclin.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Epoprostenol; Female; Humans; Mammary Arteries; Middle Aged; Muscle, Smooth, Vascular; Pregnancy; Prostaglandins; Saphenous Vein; Thromboxane A2; Thromboxanes; Umbilical Arteries; Umbilical Veins | 1983 |
The role of ADP secretion and thromboxane synthesis in factor VIII binding to platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Factor VIII; Humans; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxane A2; Thromboxanes | 1983 |
Thromboxane A2 generation by the larval cestode, Taenia taeniaeformis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Horses; Imidazoles; Indomethacin; Kinetics; Larva; Platelet Aggregation; Rats; Taeniasis; Thromboxane A2; Thromboxane B2; Thromboxanes | 1983 |
Effects of ASA on thromboxane and prostacyclin synthesis by rabbit aorta and pulmonary artery.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Female; In Vitro Techniques; Prostaglandins; Pulmonary Artery; Rabbits; Thromboxane A2; Thromboxane B2; Thromboxanes; Time Factors | 1983 |
Fenflumizole: interactions with the arachidonic acid cascade.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Platelets; Cattle; Cyclooxygenase Inhibitors; Dinoprostone; Drug Interactions; Epoprostenol; Exudates and Transudates; Guinea Pigs; Imidazoles; In Vitro Techniques; Indomethacin; Inflammation; Male; Platelet Aggregation; Prostaglandins E; Rabbits; Rats; Rats, Inbred Strains; Thromboxane A2 | 1983 |
Prostaglandins and related compounds -- a general physiologic control system.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Diet; Epoprostenol; Fatty Acids; Female; Humans; Indomethacin; Pregnancy; Prostaglandins; SRS-A; Thromboxane A2; Thromboxanes | 1983 |
Structural requirements for preventing the aspirin- and the arachidonate-induced inactivation of platelet cyclo-oxygenase: additional evidence for distinct enzymatic sites.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Rabbits; Salicylates; Structure-Activity Relationship; Thromboxane A2 | 1984 |
Reversible inhibition of thromboxane A2 production by imidazole 2-hydroxybenzoate (ITF 182) in the arachidonic acid injected rat. A comparison with acetylsalicylic acid and indometacin.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Imidazoles; Indomethacin; Injections, Intravenous; Male; Prostaglandins; Rats; Rats, Inbred Strains; Salicylates; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes | 1984 |
Prostaglandin endoperoxides and thromboxane A2 in thrombus formation in the hamster cheek pouch in vivo.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cheek; Cricetinae; Cyclooxygenase Inhibitors; Dipyridamole; Epoprostenol; Male; Mesocricetus; Microscopy, Electron; Platelet Aggregation; Sulfinpyrazone; Thrombosis; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1984 |
Human lymphocyte aggregation?
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Cell Aggregation; Humans; In Vitro Techniques; Lymphocytes; Prostaglandin-Endoperoxide Synthases; Thromboxane A2 | 1984 |
Mechanism of nitroglycerin-induced coronary dilatation: lack of relation to intracoronary thromboxane concentrations.
Topics: Adult; Aged; Aspirin; Coronary Circulation; Coronary Disease; Coronary Vessels; Female; Humans; Male; Middle Aged; Nitroglycerin; Thromboxane A2; Thromboxane B2; Thromboxanes; Vasodilation | 1984 |
[Thrombocyte interaction with a collagen substrate: the role of thrombocyte-synthesized prostaglandin endoperoxides and thromboxane A2].
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Humans; Microscopy, Electron, Scanning; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Thrombosis; Thromboxane A2; Thromboxanes | 1984 |
Role of platelet-prostaglandin synthesis in shear-induced platelet alterations.
Topics: Aspirin; beta-Thromboglobulin; Blood Platelets; Female; Humans; L-Lactate Dehydrogenase; Male; Platelet Aggregation; Platelet Count; Prostaglandins; Serotonin; Stress, Mechanical; Thromboxane A2 | 1980 |
One milligramme of acetylsalicylic acid daily inhibits platelet thromboxane A2 production.
Topics: Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Humans; Platelet Count; Thromboxane A2; Thromboxanes | 1984 |
Effect of prolonged treatment with acetylsalicylic acid and dipyridamole on platelet thromboxane A2 production in atherosclerotic subjects.
Topics: Aged; Arteriosclerosis; Aspirin; Blood Platelets; Dipyridamole; Female; Humans; Kinetics; Male; Thromboxane A2; Thromboxane B2; Thromboxanes | 1983 |
Leukotriene-induced contraction and thromboxane production in guinea-pig lung parenchymal strips.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Dinoprost; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Lung; Muscle Contraction; Muscle, Smooth; Prostaglandins F; SRS-A; Thromboxane A2; Thromboxanes | 1984 |
One, two, three or more pathways for platelet aggregation.
Topics: Acetophenones; Adenosine Diphosphate; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Humans; Lysophosphatidylcholines; Platelet Activating Factor; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thrombin; Thromboxane A2 | 1980 |
Testosterone potentiation of ionophore and ADP induced platelet aggregation: relationship to arachidonic acid metabolism.
Topics: Adenosine Diphosphate; Animals; Anti-Bacterial Agents; Arachidonic Acids; Aspirin; Blood Platelets; Calcimycin; Humans; Indomethacin; Platelet Aggregation; Rabbits; Serum Albumin; Testosterone; Thromboxane A2 | 1981 |
The effect of sulphinpyrazone on whole blood thromboxane and prostacyclin generation in man.
Topics: Adult; Aspirin; Collagen; Cyclooxygenase Inhibitors; Depression, Chemical; Epoprostenol; Humans; Leukocytes; Platelet Aggregation; Prostaglandins; Radioimmunoassay; Stimulation, Chemical; Sulfinpyrazone; Thromboxane A2; Thromboxanes; Time Factors | 1982 |
Comparison of umbilical vein models for measurement of relative prostacyclin and thromboxane production.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Arachidonic Acids; Aspirin; Epoprostenol; Humans; Methacrylates; Models, Biological; Prostaglandins; Specimen Handling; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes; Umbilical Veins | 1982 |
Arachidonic acid metabolites, hypertension and arteriosclerosis.
Topics: Arachidonic Acids; Arteriosclerosis; Aspirin; Dinoprostone; Humans; Hypertension; Platelet Adhesiveness; Prostaglandins; Prostaglandins E; Thromboxane A2 | 1982 |
Biological significance and therapeutic potential of prostacyclin.
Topics: Animals; Arteriosclerosis; Aspirin; Blood Coagulation; Blood Platelets; Epoprostenol; Humans; Lipid Peroxides; Platelet Aggregation; Prostaglandins; Thromboxane A2 | 1980 |
Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives.
Topics: Animals; Aspirin; Blood Platelets; Bronchial Spasm; Epoprostenol; In Vitro Techniques; Lysophosphatidylcholines; Platelet Activating Factor; Platelet Aggregation; Prostaglandins; Rabbits; Thromboxane A2; Time Factors | 1980 |
Inhibition of prostacyclin and platelet thromboxane A2 after low-dose aspirin.
Topics: Adult; Aspirin; Bleeding Time; Blood Platelets; Epoprostenol; Female; Humans; In Vitro Techniques; Male; Platelet Aggregation; Prostaglandin Antagonists; Thromboxane A2; Thromboxanes; Veins | 1981 |
The anti-thrombotic effects of prostacyclin.
Topics: Animals; Arteries; Aspirin; Cardiovascular Diseases; Dipyridamole; Epoprostenol; Fatty Acids; Hemostasis; Homeostasis; Humans; Lipid Peroxides; Platelet Aggregation; Prostaglandins; Thrombosis; Thromboxane A2 | 1980 |
Enhanced platelet accumulation onto injured carotid arteries in rabbits after aspirin treatment.
Topics: Animals; Aspirin; Blood Platelets; Carotid Arteries; Carotid Artery Injuries; Carotid Artery Thrombosis; Dose-Response Relationship, Drug; Epoprostenol; Microscopy, Electron; Platelet Aggregation; Rabbits; Thromboxane A2; Time Factors | 1981 |
Activation of guinea-pig platelets induced by convulxin, a substance extracted from the venom of Crotalus durissus cascavella.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Blood Platelets; Crotalid Venoms; Epoprostenol; Guinea Pigs; In Vitro Techniques; Indomethacin; Lectins, C-Type; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1980 |
Humoral heartache -- do platelets have a role?
Topics: Angina Pectoris; Angina Pectoris, Variant; Animals; Aspirin; Blood Platelets; Coronary Circulation; Dogs; Epoprostenol; Humans; Indomethacin; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Thromboxanes | 1981 |
Inhibition of prostacyclin and platelet thromboxane A2 by aspirin.
Topics: Animals; Aspirin; Blood Platelets; Epoprostenol; Humans; Prostaglandin Antagonists; Rats; Thromboxane A2; Thromboxanes | 1981 |
Respiratory movements alter the generation of prostacyclin and thromboxane A2 in isolated rat lungs: the influence of arachidonic acid-pathway inhibitors on the ratio between pulmonary prostacyclin and thromboxane A2.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acids; Aspirin; Epoprostenol; Fatty Acids; Hyperventilation; Indomethacin; Lung; Male; Prostaglandins; Prostaglandins F; Rats; Thromboxane A2; Thromboxanes; Tranylcypromine | 1981 |
[The role of prostacycline, thromboxane A2 and prostaglandins in platelet aggregation (author's transl)].
Topics: Arteriosclerosis; Aspirin; Epoprostenol; Hemostasis; Platelet Aggregation; Prostaglandin Antagonists; Prostaglandins; Thrombosis; Thromboxane A2; Thromboxanes | 1981 |
Leukotriene-C4 induces generation of PGI2 and TXA2 in guinea-pig in vivo.
Topics: Airway Resistance; Animals; Aspirin; Blood Pressure; Epoprostenol; Guinea Pigs; Lung; Lung Compliance; Muscle Contraction; Muscle, Smooth, Vascular; Prostaglandins; SRS-A; Thromboxane A2; Thromboxanes | 1981 |
Prostacyclin and thromboxane A2 formation in response to adrenergic stimulation in humans: a mechanism for local control of vascular response to sympathetic activation?
Topics: Adolescent; Adrenergic Fibers; Adult; Aspirin; Catecholamines; Cold Temperature; Epoprostenol; Female; Humans; Male; Prostaglandins; Thromboxane A2; Thromboxanes; Vascular Resistance | 1981 |
Prostacyclin and thromboxane A2 release in isolated rat lungs.
Topics: Animals; Aspirin; Blood Platelets; Cell Membrane; Epoprostenol; In Vitro Techniques; Lung; Male; Phospholipases A; Phospholipases A2; Prostaglandins; Quinacrine; Rats; Rats, Inbred Strains; Thromboxane A2; Thromboxanes | 1982 |
Platelets and coronary heart disease: therapy update.
Topics: Arteriosclerosis; Aspirin; Blood Platelets; Coronary Disease; Dipyridamole; Epoprostenol; Hemostasis; Humans; Propranolol; Prostaglandin Antagonists; Risk; Sulfinpyrazone; Thromboxane A2 | 1982 |
Failure of thromboxane A2 blockade to prevent attacks of vasospastic angina.
Topics: Adult; Aspirin; Coronary Disease; Coronary Vasospasm; Electrocardiography; Humans; Male; Middle Aged; Thromboxane A2; Thromboxane B2; Thromboxanes | 1982 |
Constitutional thrombocytopathy with subnormal response to thromboxane A2.
Topics: Adolescent; Aspirin; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets; Female; Humans; Platelet Aggregation; Serotonin; Thromboxane A2; Thromboxanes | 1981 |
Heparin inhibits the formation of endoperoxide metabolites in rat platelets: aspirin-like activity.
Topics: Animals; Aspirin; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Heparin; Male; Platelet Aggregation; Prostaglandins E; Rats; Thromboxane A2; Thromboxanes | 1981 |
Determination of specific inhibitors of thromboxane A2 formation.
Topics: Achilles Tendon; Animals; Aorta; Aspirin; Blood Platelets; Clotrimazole; Depression, Chemical; Gastric Mucosa; In Vitro Techniques; Rabbits; Thromboxane A2; Thromboxanes | 1980 |
Is tartrazine-induced asthma related to inhibition of prostaglandin biosynthesis?
Topics: Aspirin; Asthma; Azo Compounds; Blood Platelets; Humans; Platelet Aggregation; Prostaglandins; Sulfanilic Acids; Tartrazine; Thromboxane A2 | 1980 |
Bronchoconstriction by histamine and bradykinin in guinea pigs: relationship to thromboxane A2 generation and the effect of aspirin.
Topics: Acetylcholine; Animals; Aspirin; Blood Pressure; Bradykinin; Bronchial Spasm; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine; Male; Pulse; Rabbits; Thromboxane A2; Thromboxanes | 1980 |
PAF effects on eicosanoid release in neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Aspirin; Azepines; Cyclooxygenase Inhibitors; Epoprostenol; Heart; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thromboxane A2; Triazoles | 1995 |
Beneficial effect of CV-4151 (Isbogrel), a thromboxane A2 synthase inhibitor, in a rat middle cerebral artery thrombosis model.
Topics: Animals; Aspirin; Brain Chemistry; Brain Edema; Cerebral Arteries; Cerebral Infarction; Drug Evaluation, Preclinical; Fatty Acids, Monounsaturated; Fibrinolytic Agents; Guinea Pigs; Intracranial Embolism and Thrombosis; Lactates; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methacrylates; Photochemistry; Potassium; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; Rose Bengal; Sodium; Thromboxane A2; Ticlopidine | 1995 |
Enhanced arachidonic acid metabolism in alveolar macrophages from wheezy infants. Modulation by dexamethasone.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Calcimycin; Case-Control Studies; Dexamethasone; Dose-Response Relationship, Drug; Female; Glucocorticoids; Humans; In Vitro Techniques; Infant; Ionophores; Leukotriene B4; Lysine; Macrophages, Alveolar; Male; Respiratory Sounds; Thromboxane A2 | 1995 |
Stimulation of glycogen phosphorylase in rat hepatocytes via prostanoid release from Kupffer cells by recombinant rat anaphylatoxin C5a but not by native human C5a in hepatocyte/Kupffer cell co-cultures.
Topics: Acetylglucosaminidase; Animals; Aspirin; Cells, Cultured; Coculture Techniques; Complement C5a; Kupffer Cells; Liver; Male; Norepinephrine; Phosphorylases; Prostaglandins; Rats; Rats, Wistar; Recombinant Proteins; Thromboxane A2; Thromboxane B2 | 1995 |
[The effect of peripheral blood mononuclear cell products from children with nephrotic syndrome on thromboxane A2 metabolism].
Topics: Albuminuria; Animals; Aspirin; Blood Platelets; Cells, Cultured; Child; Female; Humans; Kidney Glomerulus; Leukocytes, Mononuclear; Male; Nephrosis, Lipoid; Rats; Rats, Wistar; Thromboxane A2 | 1995 |
[Aspirin--yes, but 30 mg??].
Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Epoprostenol; Humans; Myocardial Infarction; Recurrence; Thromboxane A2; Thromboxane-A Synthase | 1995 |
Implications of the prognostic importance of exercise-induced thromboxane formation in survivors of an acute myocardial infarction.
Topics: 6-Ketoprostaglandin F1 alpha; Adrenergic beta-Antagonists; Adult; Aged; Aspirin; Epoprostenol; Exercise; Exercise Test; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Myocardial Infarction; Prognosis; Thromboxane A2; Thromboxane B2 | 1995 |
Failure of aspirin to interfere with the cardioprotective effects of ifetroban.
Topics: Animals; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Drug Interactions; Ferrets; Heart; Hemodynamics; Male; Myocardial Reperfusion Injury; Oxazoles; Propionates; Receptors, Thromboxane; Thromboxane A2 | 1994 |
Effects of a thromboxane A2-receptor antagonist, a thromboxane synthetase inhibitor and aspirin on prostaglandin I2 production in endothelium-intact and -injured aorta of guinea pigs.
Topics: Angioplasty, Balloon; Animals; Aorta, Thoracic; Aspirin; Benzimidazoles; Benzoxepins; Endothelium, Vascular; Epoprostenol; Guinea Pigs; In Vitro Techniques; Male; Methacrylates; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase | 1994 |
Increased number of thromboxane A2-prostaglandin H2 platelet receptors in active unstable angina and causative role of enhanced thrombin formation.
Topics: Aged; Angina Pectoris; Angina, Unstable; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Fibrinopeptide A; Heparin; Humans; Middle Aged; Physical Exertion; Platelet Activation; Prostaglandins H; Radioligand Assay; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thrombin; Thromboxane A2 | 1995 |
Endothelium-dependent contraction induced by acetylcholine in isolated rat renal arteries.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arginine; Aspirin; Atropine; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Hexamethonium; Hydrazines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroarginine; Phospholipases A; Quinacrine; Rats; Rats, Inbred WKY; Receptors, Prostaglandin; Renal Artery; Terpenes; Thromboxane A2; Thromboxane-A Synthase | 1995 |
The effects of aspirin and paracetamol on the aggregation of equine blood platelets.
Topics: Acetaminophen; Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Cell Size; Collagen; Dose-Response Relationship, Drug; Horses; In Vitro Techniques; Nephelometry and Turbidimetry; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1994 |
Is coronary artery disease associated with radiotherapy preventable by salicylates?
Topics: Animals; Aspirin; Coronary Disease; Epoprostenol; Humans; Radiotherapy; Thromboxane A2 | 1995 |
Purification and characterization of L-amino acid oxidase from king cobra (Ophiophagus hannah) venom and its effects on human platelet aggregation.
Topics: Alprostadil; Amino Acid Oxidoreductases; Animals; Antimycin A; Aspirin; Blood Coagulation Tests; Blood Platelets; Catalase; Chromatography, Gel; Chromatography, Ion Exchange; Drug Interactions; Edetic Acid; Elapid Venoms; Electrophoresis, Polyacrylamide Gel; Heparin; Hirudins; Humans; Hydrogen Peroxide; Indomethacin; Isoelectric Point; L-Amino Acid Oxidase; Molecular Weight; Nitroprusside; Platelet Aggregation; Quinacrine; Thromboxane A2; Verapamil | 1994 |
Antithrombotic effects of KW-3635, a thromboxane A2-receptor antagonist, in guinea pigs.
Topics: Animals; Arterial Occlusive Diseases; Aspirin; Benzimidazoles; Benzoxepins; Blood Coagulation; Blood Platelets; Disease Models, Animal; Erythrocyte Count; Femoral Artery; Guinea Pigs; Lauric Acids; Male; Phenylacetates; Platelet Count; Sulfonamides; Thrombosis; Thromboxane A2; Thromboxanes; Ticlopidine | 1994 |
The novel thromboxane A2 receptor antagonist KW-3635 abolishes the cyclic flow reduction in the canine carotid artery.
Topics: Animals; Aspirin; Benzimidazoles; Benzoxepins; Carotid Arteries; Dogs; Female; Fibrinolytic Agents; Male; Platelet Aggregation Inhibitors; Receptors, Thromboxane; Regional Blood Flow; Thromboxane A2 | 1994 |
Prevention of intra-coronary thrombosis in the anaesthetised dog: the importance of thromboxane A2 and thrombin.
Topics: Anesthesia; Animals; Aspirin; Biphenyl Compounds; Blood Coagulation Tests; Coronary Circulation; Coronary Thrombosis; Dogs; Drug Synergism; Drug Therapy, Combination; Electric Stimulation; Female; Fibrinolytic Agents; Heptanoic Acids; Hirudin Therapy; Hirudins; Male; Platelet Aggregation; Recombinant Proteins; Thrombin; Thromboxane A2; Ticlopidine | 1994 |
Two distinct mechanisms of inhibition of platelets aggregation by acetylsalicylic acid.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Humans; Phospholipases A; Platelet Aggregation; Platelet Aggregation Inhibitors; Ristocetin; Thromboxane A2; von Willebrand Factor | 1994 |
Effect of picotamide on the calcium mobilization and phospholipase C activation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Chromatography, Gel; Enzyme Activation; Humans; In Vitro Techniques; Phthalic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptors, Thromboxane; Thrombin; Thromboxane A2; Type C Phospholipases | 1994 |
Protective effects of KW-3635, a thromboxane A2 antagonist, on arachidonic acid-induced transient cerebral ischemia in dogs.
Topics: Animals; Arachidonic Acid; Aspirin; Benzimidazoles; Benzoxepins; Blood Pressure; Carotid Arteries; Cerebrovascular Circulation; Dogs; Electroencephalography; Female; Heart Rate; In Vitro Techniques; Injections, Intra-Arterial; Ischemic Attack, Transient; Male; Platelet Aggregation; Thromboxane A2 | 1994 |
Renal synthesis of prostaglandins and thromboxane has no causative role for protein-induced glomerular hyperfiltration in healthy humans.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Adult; Aspirin; Dietary Proteins; Dinoprostone; Eating; Female; Glomerular Filtration Rate; Humans; Injections, Intravenous; Kidney; Kidney Glomerulus; Meat; Prostaglandins; Thromboxane A2; Time Factors | 1994 |
Inhibitory effect of KW-3635, a new thromboxane A2-receptor antagonist, on arterial thrombosis in guinea pigs.
Topics: Animals; Arachidonic Acid; Aspirin; Benzimidazoles; Benzoxepins; Collagen; Disease Models, Animal; Femoral Artery; Guinea Pigs; Male; Phenylacetates; Platelet Aggregation; Sulfonamides; Thrombosis; Thromboxane A2 | 1993 |
Different roles of prostaglandins in thromboembolic processes in arterioles and venules in vivo.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arterioles; Aspirin; Epoprostenol; Female; Hydroxyeicosatetraenoic Acids; Leukocytes; Male; Mesentery; Platelet Activation; Prostaglandins; Rabbits; Receptors, Thromboxane; Regional Blood Flow; Sulfonamides; Thromboembolism; Thromboxane A2; Venules; Videotape Recording | 1993 |
Altered eicosanoid levels in human colon cancer.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Aspirin; Colonic Neoplasms; Dinoprostone; Eicosanoids; Epoprostenol; Female; Humans; Intestinal Mucosa; Leukotriene B4; Male; Middle Aged; Thromboxane A2; Time Factors | 1993 |
Effect of policosanol on cerebral ischemia in Mongolian gerbils: role of prostacyclin and thromboxane A2.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Brain Ischemia; Drug Synergism; Epoprostenol; Fatty Alcohols; Gerbillinae; Thromboxane A2; Thromboxane B2 | 1993 |
Protein-tyrosine kinase p72syk is activated by thromboxane A2 mimetic U44069 in platelets.
Topics: Animals; Apyrase; Aspirin; Blood Platelets; Calcium; Enzyme Activation; Enzyme Precursors; Intracellular Signaling Peptides and Proteins; Prostaglandin Endoperoxides, Synthetic; Protein-Tyrosine Kinases; Swine; Syk Kinase; Thromboxane A2 | 1993 |
Alleviation of experimental cyclosporin A nephrotoxicity by low dose aspirin in the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Creatinine; Cyclosporine; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; Thromboxane A2; Urea | 1993 |
A clinical trial of a slow-release formulation of acetylsalicylic acid in patients at risk for preeclampsia.
Topics: Adult; Aspirin; Delayed-Action Preparations; Female; Fetal Blood; Humans; Indicators and Reagents; Infant, Newborn; Maternal-Fetal Exchange; Pre-Eclampsia; Pregnancy; Risk; Salicylates; Salicylic Acid; Thromboxane A2 | 1993 |
Increased in vivo production of thromboxane in patients with sickle cell disease is accompanied by an impairment of platelet functions to the thromboxane A2 agonist U46619.
Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Anemia, Sickle Cell; Aspirin; Blood Platelets; Female; Humans; Male; Phosphorylation; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxane A2; Thromboxane B2 | 1993 |
Renal prostaglandins and thromboxane A2 lack a functional significance in the genesis of protein-induced glomerular hyperfiltration in human renal disease.
Topics: Adult; Arachidonic Acids; Aspirin; Dietary Proteins; Dinoprost; Dinoprostone; Female; Glomerular Filtration Rate; Humans; Hyperemia; Kidney Diseases; Prostaglandins; Thromboxane A2 | 1993 |
Importance of secondary TXA2 release in mediating of endothelin-1 induced bronchoconstriction and vasopressin in the guinea-pig.
Topics: Animals; Aspirin; Blood Pressure; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Endothelins; Guinea Pigs; Imidazoles; Male; Naphthalenes; Prostaglandin-Endoperoxide Synthases; Receptors, Thromboxane; Sulfonamides; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Vasopressins | 1993 |
Excretion of thromboxane metabolites in healthy women after cessation of smoking.
Topics: Administration, Oral; Adult; Aspirin; Cotinine; Creatinine; Female; Humans; Middle Aged; Smoking; Smoking Cessation; Thromboxane A2; Thromboxanes | 1993 |
Antiaggregating and vasodilatory effects of a new nitroderivative of acetylsalicylic acid.
Topics: Adult; Animals; Aorta, Thoracic; Arachidonic Acid; Aspirin; Female; Humans; Muscle, Smooth, Vascular; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thrombin; Thromboxane A2; Vasodilation | 1995 |
A ferret model of electrical-induction of arterial thrombosis that is sensitive to aspirin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Carotid Arteries; Carotid Artery Injuries; Collagen; Disease Models, Animal; Electric Stimulation; Ferrets; Fibrin; Humans; In Vitro Techniques; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Oxazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Prothrombin Time; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Species Specificity; Thrombosis; Thromboxane A2; Vasoconstrictor Agents | 1996 |
Native lipoproteins inhibit platelet activation induced by oxidized lipoproteins.
Topics: Aspirin; Calcium; Copper; Copper Sulfate; Humans; In Vitro Techniques; Kinetics; Lipid Peroxidation; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Malondialdehyde; Oxidation-Reduction; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Thiobarbituric Acid Reactive Substances; Thromboxane A2; Time Factors | 1996 |
Platelet-activating factor and not thromboxane A2 is an important mediator of endotoxin-induced platelet aggregation in equine heparinised whole blood in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azepines; Carbazoles; Clonixin; Endotoxins; Heparin; Horses; In Vitro Techniques; Phospholipases A; Phospholipases A2; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinacrine; Thromboxane A2; Triazoles | 1996 |
In vitro study of the anti-aggregating activity of two nitroderivatives of acetylsalicylic acid.
Topics: Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2; Thromboxane B2 | 1996 |
Magnesium inhibits human platelets.
Topics: Aspirin; Blood Platelets; Collagen; Female; Hirudins; Humans; In Vitro Techniques; Magnesium; Magnesium Sulfate; Male; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1996 |
Effect of single and repeated doses of a new nitroderivative of acetylsalicylic acid on platelet TXA2 production in rats.
Topics: Animals; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Female; Nitrites; Rats; Rats, Sprague-Dawley; Thromboxane A2; Thromboxane B2 | 1996 |
Platelet reactivity in vitro in relation to thromboxane in healthy pregnancy.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adolescent; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cross-Sectional Studies; Cyclic AMP; Dioxanes; Female; Humans; Imidazoles; Platelet Aggregation; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Thromboxane-A Synthase | 1996 |
Inhibition of arachidonic acid induced-aggregation of rabbit platelets with CV-4151 (isbogrel), a selective thromboxane A2 (TXA2) synthase inhibitor: modulation of the antiplatelet action and prostanoid metabolism by rat aortic rings.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Arachidonic Acid; Aspirin; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Epoprostenol; Fatty Acids, Monounsaturated; In Vitro Techniques; Intramolecular Oxidoreductases; Isomerases; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; Thromboxane A2; Thromboxane-A Synthase | 1996 |
Two mechanisms for platelet-mediated killing of tumour cells: one cyclo-oxygenase dependent and the other nitric oxide dependent.
Topics: Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Cytotoxicity, Immunologic; Hemoglobins; Humans; Indomethacin; Methylene Blue; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Tumor Cells, Cultured | 1996 |
The antiplatelet effects of a new nitroderivative of acetylsalicylic acid--an in vitro study of inhibition on the early phase of platelet activation and on TXA2 production.
Topics: Adult; Aspirin; Blood Platelets; Calcium; Cyclic GMP; Humans; P-Selectin; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thromboxane A2 | 1996 |
Effect of prostaglandin E2 on eicosanoid release by human bronchial biopsy specimens from normal and inflamed mucosa.
Topics: Adult; Aged; Arachidonic Acids; Aspirin; Biopsy; Bronchi; Bronchitis; Caffeic Acids; Dinoprostone; Eicosanoids; Humans; Leukotrienes; Middle Aged; Thromboxane A2 | 1996 |
Mechanism of the contractile effect of diaspirin-cross-linked hemoglobin in rat isolated aorta strip denuded of endothelium as revealed using an oil-immersion procedure.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antioxidants; Aorta, Thoracic; Arachidonic Acid; Aspirin; Blood Substitutes; Cytological Techniques; Endothelium, Vascular; Hemoglobins; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Sprague-Dawley; Thromboxane A2; Vasoconstrictor Agents | 1996 |
Effects of U73122 and U73343 on human platelet calcium signalling and protein tyrosine phosphorylation.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Blood Proteins; Calcium; Collagen; Estrenes; Humans; Phosphodiesterase Inhibitors; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pyrrolidinones; Signal Transduction; Thapsigargin; Thrombin; Thromboxane A2; Type C Phospholipases | 1997 |
Cell-cell interaction between platelets and IL-1 beta-stimulated vascular smooth muscle cells in synthesis of thromboxane A2.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Cell Communication; Cells, Cultured; Coculture Techniques; Cycloheximide; Dactinomycin; Humans; Interleukin-1; Muscle, Smooth, Vascular; Phospholipids; Prostaglandin Endoperoxides; Prostaglandin H2; Prostaglandins H; Rats; Recombinant Proteins; Thrombin; Thromboxane A2 | 1997 |
Acetylsalicylic acid is unlikely to beneficially interfere with radiation-induced vasculopathy.
Topics: Aspirin; Coronary Disease; Epoprostenol; Humans; Platelet Aggregation Inhibitors; Radiotherapy; Salicylates; Thromboxane A2 | 1997 |
The potent inhibition of vapiprost, a novel thromboxane A2 receptor antagonist, on the secondary aggregation and ATP release of human platelets.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Aspirin; Biphenyl Compounds; Blood Platelets; Guinea Pigs; Heptanoic Acids; Humans; Male; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Rabbits; Rats; Rats, Wistar; Receptors, Thromboxane; Species Specificity; Thromboxane A2 | 1997 |
Experimental fat embolism induces urine 2,3-dinor-6-ketoprostaglandin F1alpha and 11-dehydrothromboxane B2 excretion in pigs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Cyclooxygenase Inhibitors; Embolism, Fat; Epoprostenol; Evaluation Studies as Topic; Hemodynamics; Hypertension, Pulmonary; Lung Diseases; Random Allocation; Swine; Thromboxane A2; Thromboxane B2 | 1997 |
Effect of vitamin E supplementation on prostaglandin concentrations in aspirin-induced acute gastric injury in aged rats.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Aging; Animals; Aspirin; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; Male; Prostaglandins; Rats; Rats, Sprague-Dawley; Thromboxane A2; Vitamin E | 1997 |
Methacholine-induced contraction of rabbit pulmonary artery: role of platelet-endothelial transcellular thromboxane synthesis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Endothelium, Vascular; In Vitro Techniques; Male; Methacholine Chloride; Models, Cardiovascular; Muscle Contraction; Muscle, Smooth, Vascular; Pulmonary Artery; Rabbits; Thromboxane A2; Vasoconstriction | 1998 |
Inhibitory actions of ONO-3708 on the stretch-induced contraction potentiated by hemolysate/oxyhemoglobin studied in dog cerebral artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Cerebral Arteries; Cyclooxygenase Inhibitors; Dinoprost; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Female; Male; Methacrylates; Muscle Contraction; Muscle, Smooth, Vascular; Oxyhemoglobins; Oxytocics; Reflex, Stretch; Thromboxane A2; Thromboxane-A Synthase; Vasoconstrictor Agents | 1997 |
Human platelet inhibition of Toxoplasma gondii growth.
Topics: Animals; Aspirin; Bicyclic Monoterpenes; Blood Platelets; Humans; Imidazoles; Insulin; Interleukin-6; Platelet Activation; Platelet-Derived Growth Factor; Thromboxane A2; Toxoplasma; Uracil | 1998 |
Aspirin increases the bleeding side effects in essential thrombocythemia independent of the cyclooxygenase pathway: role of the lipoxygenase pathway.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Aspirin; Bleeding Time; Blood Coagulation; Humans; Lipoxygenase; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Thrombocythemia, Essential; Thromboxane A2 | 1998 |
Cellular activation by thromboxane A2 and 8-EPI-PGF2 alpha.
Topics: Animals; Aspirin; Cell Line; Cyclic AMP-Dependent Protein Kinases; Dinoprost; Humans; Point Mutation; Protein Kinase C; Receptors, Thromboxane; Recombinant Proteins; Thromboxane A2; Transfection; Vasoconstrictor Agents | 1997 |
Difference of (Ca2+)i movements in platelets stimulated by thrombin and TRAP: the involvement of alpha(IIb)beta3-mediated TXA2 synthesis.
Topics: Adenosine Diphosphate; Antibodies, Monoclonal; Apyrase; Aspirin; Blood Platelets; Calcium; Cyclooxygenase Inhibitors; Dipeptides; Fibrinogen; Humans; Ion Transport; Peptide Fragments; Phenylacetates; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Thrombin; Signal Transduction; Sulfonamides; Thrombin; Thromboxane A2; Thromboxane B2; Tirofiban; Tyrosine | 1998 |
[In vitro study of the mechanism of the platelet anti-aggregant action of picotamide (G 137)].
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Humans; Malondialdehyde; Molecular Structure; Phthalic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Structure-Activity Relationship; Thromboxane A2; Thromboxane-A Synthase | 1983 |
Effective long-term inhibition of thromboxane production but not of serotonin release in patients with coronary heart disease by 30 mg/d acetylsalicylic acid dosage.
Topics: Aspirin; Blood Coagulation; Coronary Disease; Dose-Response Relationship, Drug; Humans; Myocardial Ischemia; Serotonin; Thromboxane A2; Thromboxane B2 | 1998 |
[Mechanism of changes in the platelet functional activity caused by low energy laser irradiation].
Topics: Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Humans; Imidazoles; In Vitro Techniques; Lasers; Platelet Aggregation; Platelet Count; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Thromboxane-A Synthase | 1998 |
Focused antithrombotic therapy: novel anti-platelet salicylates with reduced ulcerogenic potential and higher first-pass detoxification than aspirin in rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Blood Platelets; Diflunisal; Dose-Response Relationship, Drug; Female; Fibrinolytic Agents; Gastric Mucosa; In Vitro Techniques; Inactivation, Metabolic; Liver; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Steroids; Stomach Ulcer; Thromboxane A2 | 1998 |
Involvement of thromboxane A2 and prostacyclin in the early pulmonary hypertension after porcine meconium aspiration.
Topics: Adaptation, Physiological; Animals; Animals, Newborn; Aspirin; Cyclooxygenase Inhibitors; Disease Models, Animal; Epoprostenol; Humans; Infant, Newborn; Meconium Aspiration Syndrome; Persistent Fetal Circulation Syndrome; Swine; Thromboxane A2; Time Factors | 1998 |
Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets.
Topics: Arachidonic Acid; Aspirin; Biphenyl Compounds; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Electrophoresis, Polyacrylamide Gel; Fatty Acids, Unsaturated; Heptanoic Acids; Humans; Hydrazines; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Protein Kinase C; Receptors, Thromboxane; Thrombin; Thromboxane A2 | 1999 |
Inhibition of platelet aggregation by S-nitroso-cysteine via cGMP-independent mechanisms: evidence of inhibition of thromboxane A2 synthesis in human blood platelets.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Cyclic GMP; Cysteine; Fatty Acids, Unsaturated; Glutathione; Guanylate Cyclase; Humans; Hydrazines; Inhibitory Concentration 50; Nitric Oxide; Nitrites; Nitroprusside; Nitroso Compounds; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines; S-Nitrosoglutathione; S-Nitrosothiols; Thromboxane A2 | 1999 |
Production of prostanoids and nitric oxide by infarcted heart in situ and the effect of aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Coronary Vessels; Enzyme Activation; Epoprostenol; Heart; Myocardial Infarction; Myocardium; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Prostaglandins; Rabbits; Thromboxane A2; Thromboxane B2 | 1999 |
Iron-dependent human platelet activation and hydroxyl radical formation: involvement of protein kinase C.
Topics: Adult; Aspirin; Blood Platelets; Catalase; Chelating Agents; Collagen; Deferoxamine; Deoxyribose; Diuretics, Osmotic; Dose-Response Relationship, Drug; Edetic Acid; Enzyme Inhibitors; Female; Humans; Hydroxyl Radical; Indoles; Iron; Isoquinolines; Male; Maleimides; Mannitol; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Sulfonamides; Thromboxane A2; Thromboxane B2 | 1999 |
Effects of sodium selenite on in vitro interactions between platelets and endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Aspirin; Blood Platelets; Cells, Cultured; Culture Media, Conditioned; Endothelium, Vascular; Enzyme Activation; Glutathione Peroxidase; Humans; Nitric Oxide; Platelet Aggregation; Selenium; Sodium Selenite; Thromboxane A2; Thromboxane B2 | 1999 |
Monitoring of the thromboxane A2/prostacyclin ratio in the urine of patients with retinal vascular occlusion through the low-dose-aspirin therapy using the gas chromatography/selected ion monitoring method.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aspirin; Dose-Response Relationship, Drug; Epoprostenol; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Middle Aged; Pilot Projects; Prostaglandins F; Retinal Artery Occlusion; Retinal Vein Occlusion; Thromboxane A2; Thromboxane B2; Thromboxanes | 1999 |
Changes in prostacyclin, thromboxane A2 and F2-isoprostanes, and influence of eicosapentaenoic acid and antiplatelet agents in patients with hypertension and hyperlipidemia.
Topics: Aspirin; Dinoprost; Dipyridamole; Eicosapentaenoic Acid; Epoprostenol; Humans; Hyperlipidemias; Hypertension; Platelet Aggregation Inhibitors; Thromboxane A2; Ticlopidine | 1999 |
The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Blood Platelets; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Platelet Activation; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2Y1; Signal Transduction; Thromboxane A2; Vasoconstrictor Agents | 2000 |
The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice: evidence that eicosanoids other than thromboxane contribute to atherosclerosis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Aspirin; Body Weight; Cell Adhesion; Cholesterol; Endothelium, Vascular; Female; Humans; Intercellular Adhesion Molecule-1; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Naphthalenes; Platelet Aggregation Inhibitors; Propionates; Receptors, Thromboxane; Tetrahydronaphthalenes; Thromboxane A2; Thromboxane B2; U937 Cells; Umbilical Veins; Vasoconstrictor Agents | 2000 |
Differential regulation of prostaglandin E2 and thromboxane A2 production in human monocytes: implications for the use of cyclooxygenase inhibitors.
Topics: Arachidonic Acid; Aspirin; Cell Fractionation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Eicosanoids; Enzyme Induction; Humans; Interphase; Isoenzymes; Kinetics; Lipopolysaccharides; Membrane Proteins; Monocytes; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Thromboxane A2; Thromboxane-A Synthase; U937 Cells; Zymosan | 2000 |
Habitual smoking causes an abnormality in platelet thromboxane A2 metabolism and results in an altered susceptibility to aspirin effects.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Aspirin; Blood Platelets; Collagen; Epoprostenol; Erythrocytes; Humans; Male; Platelet Aggregation; Smoking; Thromboxane A2; Thromboxanes | 2000 |
Transcellular formation of thromboxane A(2) in mixed incubations of endothelial cells and aspirin-treated platelets strongly depends on the prostaglandin I-synthase activity.
Topics: Aspirin; Blood Platelets; Coculture Techniques; Cyclooxygenase 1; Cyclooxygenase 2; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Fatty Acids, Unsaturated; Humans; Interleukin-1; Intramolecular Oxidoreductases; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Prostaglandins; RNA, Messenger; Thromboxane A2 | 2000 |
PEP trial. Pulmonary Embolism Prevention.
Topics: Animals; Aspirin; Cause of Death; Cyclooxygenase Inhibitors; Disease Models, Animal; Humans; Platelet Aggregation Inhibitors; Pulmonary Embolism; Risk Factors; Thromboembolism; Thromboxane A2; Vasoconstrictor Agents | 2000 |
The effect of aspirin and two nitric oxide donors on the infarcted heart in situ.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Cyclooxygenase Inhibitors; Drug Interactions; Enzyme Activation; Heart Rate; Male; Myocardial Infarction; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rabbits; Thromboxane A2; Triazenes; Ventricular Pressure | 2000 |
Aspirin for the treatment of pulmonary embolism: vasoconstriction versus physical obstruction.
Topics: Aspirin; Cause of Death; Humans; Platelet Aggregation Inhibitors; Pulmonary Embolism; Survival Rate; Thromboxane A2; Vasoconstriction | 2000 |
Defective platelet response to arachidonic acid and thromboxane A(2) in subjects with Pl(A2) polymorphism of beta(3) subunit (glycoprotein IIIa).
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; beta-Thromboglobulin; Blood Platelets; Coronary Disease; Female; Flow Cytometry; Genotype; Humans; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Risk Factors; Statistics, Nonparametric; Thrombin; Thromboxane A2 | 2000 |
The central role of the P(2T) receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Analysis of Variance; Annexin A5; Aspirin; Blood Platelets; Calcium; Collagen; Cytosol; Fibrinolytic Agents; Flow Cytometry; Humans; Membrane Proteins; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Serotonin; Stimulation, Chemical; Thromboxane A2 | 2000 |
Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis.
Topics: Age Factors; Animals; Aorta; Arteriosclerosis; Aspirin; Diet, Atherogenic; Disease Models, Animal; Eicosanoids; Epoprostenol; Female; Hominidae; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins F; Receptors, LDL; Thromboxane A2; Thromboxane B2 | 2000 |
Influence of acetylsalicylic acid on development of radiation-induced nephropathy.
Topics: Animals; Aspirin; Dose-Response Relationship, Radiation; Edetic Acid; Female; Humans; In Vitro Techniques; Kidney Diseases; Kidney Function Tests; Mice; Mice, Inbred C3H; Platelet Aggregation; Radiation Injuries, Experimental; Thromboxane A2; Time Factors | 2000 |
Results of the BRAT study--a pilot study investigating the possible significance of ASA nonresponsiveness on the benefits and risks of ASA on thrombosis in patients undergoing coronary artery bypass surgery.
Topics: Aspirin; Bleeding Time; Coronary Artery Bypass; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Thrombosis; Thromboxane A2 | 2000 |
Aspirin, but not the more selective cyclooxygenase (COX)-2 inhibitors meloxicam and SC 58125, aggravates postischaemic cardiac dysfunction, independent of COX function.
Topics: Animals; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Eicosanoids; F2-Isoprostanes; Guinea Pigs; Heart; Hemodynamics; Isoenzymes; Male; Meloxicam; Myocardial Ischemia; Myocardial Reperfusion Injury; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Thiazines; Thiazoles; Thromboxane A2 | 2001 |
Effects of cyclo-oxygenase and thromboxane synthetase inhibitors on right atrial prostaglandins.
Topics: Aspirin; Benzofurans; Coronary Artery Bypass; Coronary Disease; Culture Techniques; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Heart Atria; Humans; Indomethacin; Prostaglandins; Thromboxane A2; Thromboxane-A Synthase | 2000 |
Release of tumor necrosis factor-alpha and prostanoids in whole blood cultures after in vivo exposure to low-dose aspirin.
Topics: Adult; Aspirin; Blood Cells; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Epoprostenol; Female; Furans; Humans; Isoenzymes; Leukocytes; Lipopolysaccharides; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Thromboxane A2; Tumor Necrosis Factor-alpha | 2001 |
Effect of cyclooxygenase-2 inhibitor (celecoxib) on the infarcted heart in situ.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Epoprostenol; Heart; Isoenzymes; Male; Myocardial Infarction; Myocardium; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rabbits; Sulfonamides; Thromboxane A2 | 2001 |
Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin synthesis by COX-2.
Topics: Aspirin; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Dinoprostone; Endothelium, Vascular; Enzyme Induction; Epoprostenol; Humans; Interleukin-1; Intramolecular Oxidoreductases; Isoenzymes; Kinetics; Membrane Proteins; Mitogen-Activated Protein Kinases; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Thromboxane A2; Thromboxane-A Synthase; Up-Regulation | 2001 |
Maturation reveals a decrease in endothelium-dependent contraction induced by depolarization in the aorta of spontaneously hypertensive rats.
Topics: Aging; Animals; Aorta; Aspirin; Biphenyl Compounds; Body Weight; Endothelium, Vascular; Heptanoic Acids; Hypertension; In Vitro Techniques; Muscle Contraction; Norepinephrine; Potassium Chloride; Prostaglandin Antagonists; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 2001 |
Possible involvement of mast-cell activation in aspirin provocation of aspirin-induced asthma.
Topics: Adult; Aged; Aspirin; Asthma; Bronchial Provocation Tests; Cyclooxygenase Inhibitors; Dinoprost; Female; Forced Expiratory Volume; Humans; Leukotriene E4; Male; Mast Cells; Methylhistamines; Middle Aged; Sensitivity and Specificity; Thromboxane A2; Thromboxane B2; Time Factors | 2001 |
Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Biphenyl Compounds; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Cells, Cultured; Enzyme Inhibitors; Fatty Acids, Unsaturated; Heptanoic Acids; Humans; Hydrazines; Imidazoles; Inositol Phosphates; Kidney; Methacrylates; Phenylacetates; Platelet Activating Factor; Platelet Activation; Prostaglandin H2; Prostaglandins H; Protein Isoforms; Receptors, Thromboxane; Recombinant Fusion Proteins; Sulfonamides; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 2002 |
Why are some individuals resistant to the cardioprotective effects of aspirin? Could it be thromboxane A2?
Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Dose-Response Relationship, Drug; Drug Resistance; Risk Factors; Thromboxane A2; Thromboxanes | 2002 |
The hepoxilin analog PBT-3 inhibits heparin-activated platelet aggregation evoked by ADP.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Diphosphate; Anticoagulants; Arachidonic Acids; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fatty Acids, Unsaturated; Heparin; Humans; Hydrazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2 | 2002 |
Evaluation of the effects of anti-thromboxane agents in platelet-vessel wall interaction.
Topics: Animals; Aorta, Thoracic; Arachidonic Acid; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Communication; Dinoprost; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Male; Methacrylates; Muscle Tonus; Muscle, Smooth, Vascular; Phthalic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Rabbits; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase | 2002 |
Induction of thromboxane A2 synthesizing enzymes in DMSO-induced granulocytic differentiation of HL-60 cells.
Topics: Aspirin; Cell Differentiation; Cyclooxygenase 1; Cyclooxygenase 2; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Induction; HL-60 Cells; Humans; Isoenzymes; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Time Factors | 2002 |
Uncoupled regulation of leukotriene C4 synthase in platelets from aspirin-intolerant asthmatics and healthy volunteers after aspirin treatment.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Asthma; Blood Platelets; Case-Control Studies; Collagen; Depression, Chemical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glutathione Transferase; Humans; Male; Middle Aged; Thromboxane A2 | 2002 |
[Effect of low-dosage aspirin combined with perindopril on prostacyclin, thromboxone A2, and norepinephrine in rabbits' blood].
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aspirin; Drug Synergism; Epoprostenol; Female; Male; Norepinephrine; Perindopril; Rabbits; Thromboxane A2 | 2002 |
The stable analog carbocyclic TXA2 but not platelet-released TXA2 induces osteoclast-like cell formation.
Topics: Acid Phosphatase; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Bone Marrow Cells; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Cell Nucleus; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Membrane Glycoproteins; Mice; Nitrobenzenes; Osteoclasts; Prostaglandin-Endoperoxide Synthases; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Stromal Cells; Sulfonamides; Tartrates; Thromboxane A2 | 2003 |
The promoting effect of epinephrine on lipopolysaccharide-induced interleukin-8 production in whole blood may be mediated by thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; Fatty Acids, Unsaturated; Humans; Hydrazines; Interleukin-8; Lipopolysaccharides; Receptors, Thromboxane; Thromboxane A2; Tumor Necrosis Factor-alpha | 2003 |
[Effect of aspirin combined with perindopril on prostacyclin, thromboxone A2, and norepinephrine in the blood of arteriosclerosis rabbit models and the cardiac function].
Topics: Animals; Arteriosclerosis; Aspirin; Drug Synergism; Epoprostenol; Female; Heart Function Tests; Heart Rate; Male; Norepinephrine; Perindopril; Rabbits; Random Allocation; Thromboxane A2; Thromboxane B2 | 2003 |
Biopharmaceutical characterisation of a low-dose (75 mg) controlled-release aspirin formulation.
Topics: Adolescent; Adult; Aspirin; Biological Availability; Delayed-Action Preparations; Food; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Thromboxane A2 | 1993 |
[Protective effects and mechanism of action of aspirin on focal cerebral ischemia-reperfusion in rats].
Topics: Animals; Aspirin; Brain Ischemia; Disease Models, Animal; Epoprostenol; Male; Malondialdehyde; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Thromboxane A2 | 2003 |
Effects of antiplatelet agents on pulmonary haemodynamic response to fMLP in endotoxin primed rats.
Topics: Animals; Aspirin; Blood Platelets; Cell Adhesion; Cilostazol; Endotoxins; Flow Cytometry; Hemodynamics; Lung; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Tetrazoles; Thromboxane A2 | 2004 |
Cyclooxygenase inhibition in patients with coronary artery disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Coronary Artery Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Humans; Isoenzymes; Membrane Proteins; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Thromboxane A2 | 2004 |
Mechanism of collagen activation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Benzofurans; Blood Platelets; Calcium; Collagen; Dose-Response Relationship, Drug; Egtazic Acid; Ethers, Cyclic; Fluoresceins; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Imidazoles; Inositol 1,4,5-Trisphosphate; Models, Biological; Organic Chemicals; Platelet Activation; Platelet Aggregation; Sodium; Sodium-Calcium Exchanger; Specimen Handling; Temperature; Thromboxane A2; Time Factors; Vasoconstrictor Agents | 2004 |
Cyclooxygenase involvement in thromboxane-dependent contraction in rat mesenteric resistance arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Endothelin-1; Fatty Acids, Unsaturated; Flurbiprofen; Hydrazines; Indomethacin; Isoenzymes; Male; Membrane Proteins; Mesenteric Arteries; Organic Chemicals; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred WKY; Receptors, Thromboxane A2, Prostaglandin H2; Sulfonamides; Thromboxane A2; Vascular Resistance; Vasoconstriction | 2004 |
The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Cell Shape; Collagen; Drug Synergism; GTP-Binding Protein alpha Subunits, Gq-G11; Kinetics; Mice; Mice, Knockout; Microscopy, Electron, Scanning; Platelet Activation; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; Thromboxane A2 | 2004 |
Is your daily aspirin falling down on the job? Not everyone gets the full effect of aspirin. A new test can show if it's working for you.
Topics: Aspirin; Biomarkers; Humans; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2; Treatment Failure | 2004 |
Clopidogrel resistance: a new chapter in a fast-moving story.
Topics: Angioplasty; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Disease; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Eptifibatide; Heparin; Humans; Peptides; Platelet Aggregation Inhibitors; Stents; Thromboxane A2; Ticlopidine; Treatment Outcome | 2004 |
Functional role of NADPH oxidase in activation of platelets.
Topics: Acetophenones; Antioxidants; Aspirin; Blood Platelets; Collagen; Enzyme Inhibitors; Free Radicals; Humans; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Neutrophils; Platelet Aggregation; Platelet Aggregation Inhibitors; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Thromboxane A2; Thromboxane-A Synthase | 2004 |
Thromboxane and prostacyclin biosynthesis in patients with acute spontaneous intracerebral hemorrhage.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Aged; Aspirin; Bleeding Time; Blood Coagulation; Cerebral Hemorrhage; Epoprostenol; Female; Humans; Male; Middle Aged; Prospective Studies; Regression Analysis; Thromboxane A2; Thromboxane B2 | 2005 |
Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition.
Topics: Animals; Arachidonic Acid; Aspirin; Blood Platelets; Cyclooxygenase 1; Edema; Estradiol; Female; Humans; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovary; Parturition; Pre-Eclampsia; Pregnancy; Progesterone; Prostaglandin-Endoperoxide Synthases; Receptors, Oxytocin; Thromboxane A2; Uterus | 2005 |
Cyclooxygenase-1 haplotype modulates platelet response to aspirin.
Topics: Adult; Arachidonic Acid; Aspirin; Cardiovascular Diseases; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Resistance; Female; Haplotypes; Humans; Likelihood Functions; Male; Pharmacogenetics; Platelet Aggregation; Polymorphism, Single Nucleotide; Prospective Studies; Thromboxane A2 | 2005 |
Aspirin therapy benefits bypass surgery.
Topics: Aspirin; Coronary Artery Bypass; Fibrinolytic Agents; Heart-Lung Machine; Humans; Lung; Oxygen; Thromboxane A2 | 2005 |
2-(2-Br-phenyl)-8-methoxy-benzoxazinone (HPW-RX2), a direct thrombin inhibitor with a suppressive effect on thromboxane formation in platelets.
Topics: Adenosine Triphosphate; Arachidonic Acid; Aspirin; Benzoxazines; Blood Platelets; Calcium; Calcium Signaling; Collagen; Dose-Response Relationship, Drug; Humans; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin D2; Receptors, Thrombin; Thrombin; Thromboxane A2; Thromboxane B2 | 2005 |
NSAIDs and cardiovascular risk.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular System; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Hypertension; Lactones; Sulfones; Thromboxane A2 | 2005 |
The involvement of adhesion molecules and lipid mediators in the adhesion of human platelets to eosinophils.
Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Azepines; Blood Platelets; Cell Adhesion Molecules; Cyclooxygenase Inhibitors; Eosinophils; Humans; Immunoglobulin Fab Fragments; In Vitro Techniques; Indoles; Inflammation Mediators; L-Selectin; Lipoxygenase Inhibitors; Neutrophils; P-Selectin; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Polysaccharides; Receptors, G-Protein-Coupled; Thromboxane A2; Triazoles | 2005 |
Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2.
Topics: Aspirin; Blood Platelets; Blood Proteins; Calcimycin; Calcium; Celecoxib; Cell Line; Cerebrospinal Fluid Proteins; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Indomethacin; Ionophores; Lactones; Meloxicam; Naproxen; Organ Specificity; Organic Chemicals; Protein Binding; Pyrazoles; Sodium Salicylate; Sulfonamides; Sulfones; Synovial Fluid; Thiazines; Thiazoles; Thromboxane A2 | 2006 |
More on aspirin resistance: position paper of the Working Group on Aspirin Resistance. Proposal for a Laboratory Test Guiding Algorithm.
Topics: Algorithms; Aspirin; Blood Platelets; Drug Resistance; Humans; In Vitro Techniques; Platelet Activation; Platelet Function Tests; Software Design; Thromboxane A2 | 2006 |
De novo synthesis of cyclooxygenase-1 counteracts the suppression of platelet thromboxane biosynthesis by aspirin.
Topics: Adult; Aspirin; Blood Platelets; Cyclooxygenase 1; Dose-Response Relationship, Drug; Humans; Middle Aged; Phosphatidylinositol 3-Kinases; Platelet Aggregation Inhibitors; Protein Biosynthesis; RNA, Messenger; Thromboxane A2 | 2006 |
Biological basis and clinical implications of acetylsalicylic acid resistance.
Topics: Acetylation; Acetyltransferases; Arachidonic Acid; Aspirin; Drug Resistance; Fibrinolytic Agents; Humans; Myocardial Infarction; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Stroke; Thromboxane A2 | 2006 |
Adherence to aspirin in secondary prevention of ischemic stroke.
Topics: Adult; Aged; Ambulatory Care; Aspirin; Brain Ischemia; Female; Follow-Up Studies; Health Care Surveys; Humans; Male; Middle Aged; Patient Compliance; Platelet Aggregation Inhibitors; Stroke; Thromboxane A2 | 2006 |
Aspirin therapy for inhibition of platelet reactivity in the presence of erythrocytes in patients with vascular disease.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Brain Ischemia; Collagen; Dose-Response Relationship, Drug; Drug Administration Schedule; Erythrocytes; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Serotonin; Thromboxane A2 | 2006 |
Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism.
Topics: Antigens, Neoplasm; Aspirin; Blood Platelets; Coronary Artery Disease; Cyclooxygenase 1; Dinoprost; Drug Resistance; Humans; Integrin beta3; Lipid Peroxidation; Nephelometry and Turbidimetry; Oxidative Stress; Platelet Aggregation; Polymorphism, Genetic; Polymorphism, Single Nucleotide; RNA, Messenger; Thromboxane A2; Thromboxane B2 | 2006 |
Aspirin resistance.
Topics: Aspirin; Coronary Disease; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Resistance; Humans; Thromboxane A2 | 2006 |
The aspirin resistance controversy: clinical entity or platelet heterogeneity?
Topics: Aspirin; Coronary Artery Disease; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Activation; Female; Flow Cytometry; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prevalence; Recurrence; Thromboxane A2; Time Factors; Treatment Refusal | 2006 |
The lipoxygenase-cyclooxygenase inhibitor licofelone prevents thromboxane A2-mediated cardiovascular derangement triggered by the inflammatory peptide fMLP in the rabbit.
Topics: Acetates; Animals; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Electrocardiography; Heart Rate; Inflammation; Lactones; Leukotriene B4; Lipoxygenase Inhibitors; Male; Myocardial Ischemia; N-Formylmethionine Leucyl-Phenylalanine; Pyrroles; Rabbits; Sulfones; Thromboxane A2; Time Factors | 2006 |
Partial inhibition of platelet thromboxane A2 synthesis by aspirin is associated with myonecrosis in patients with ST-segment elevation myocardial infarction.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Case-Control Studies; Drug Resistance; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardium; Necrosis; Platelet Aggregation; Platelet Aggregation Inhibitors; Severity of Illness Index; Thromboxane A2 | 2007 |
Recent FDA warning of the concomitant use of aspirin and ibuprofen and the effects on platelet aggregation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Interactions; Humans; Ibuprofen; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2; United States; United States Food and Drug Administration | 2007 |
Relationship between vitamin D binding protein and aspirin resistance in coronary ischemic patients: a proteomic study.
Topics: Aged; Aspirin; Blood Proteins; Coronary Disease; Drug Resistance; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Isoforms; Proteome; Proteomics; Thromboxane A2; Vitamin D-Binding Protein | 2007 |
A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Coronary Artery Disease; Cyclooxygenase 1; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reference Values; Thromboxane A2 | 2007 |
Laboratory detection of 'aspirin resistance': what test should we use (if any)?
Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Cyclooxygenase 1; Drug Resistance; Humans; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2 | 2007 |
Platelet pro-aggregatory effects of CD40L monoclonal antibody.
Topics: Adenosine Diphosphate; Animals; Antibodies, Monoclonal; Aspirin; Blood Platelets; Calcium; CD40 Antigens; CD40 Ligand; Chelating Agents; Humans; Immunoglobulin Fab Fragments; In Vitro Techniques; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Swine; Thromboxane A2 | 2008 |
Role of murine integrin alpha2beta1 in thrombus stabilization and embolization: contribution of thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Chlorides; Collagen; Ferric Compounds; Integrin alpha2beta1; Mice; Mice, Knockout; Thromboembolism; Thrombosis; Thromboxane A2 | 2007 |
Residual platelet thromboxane A2 and prothrombotic effects of erythrocytes are important determinants of aspirin resistance in patients with vascular disease.
Topics: Aged; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Resistance; Erythrocytes; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet-Rich Plasma; Serotonin; Thromboxane A2; Vascular Diseases | 2008 |
Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses.
Topics: Animals; Aspirin; Azepines; Benzamides; Blood Platelets; Calcimycin; Female; Horses; Leukocytes; Lipopolysaccharides; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, G-Protein-Coupled; Serotonin; Thromboxane A2; Time Factors; Triazoles; Tryptamines; Vasoconstriction | 2008 |
Aspirin response evaluated by the VerifyNow Aspirin System and light transmission aggregometry.
Topics: Adult; Aspirin; Blood Platelets; Case-Control Studies; Coronary Artery Disease; Drug Resistance; Female; Hemoglobins; Humans; Interviews as Topic; Male; Patient Compliance; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Reproducibility of Results; ROC Curve; Sensitivity and Specificity; Thromboxane A2 | 2008 |
Circulating endothelial progenitor cells and residual in vivo thromboxane biosynthesis in low-dose aspirin-treated polycythemia vera patients.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Aspirin; Blood; Case-Control Studies; Colony-Forming Units Assay; Endothelial Cells; Female; Humans; Male; Middle Aged; Polycythemia Vera; Stem Cells; Thromboxane A2; Thromboxane B2; Thromboxanes | 2008 |
Targeting the urine and plasma determinants of thromboxane A2 metabolism in detection of aspirin effectiveness.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Resistance; Male; Models, Biological; Rats; Rats, Wistar; Thromboxane A2; Thromboxane B2 | 2008 |
Multiple anti-atherosclerotic treatments impair aspirin compliance: effects on aspirin resistance.
Topics: Arachidonic Acid; Aspirin; Atherosclerosis; Drug Resistance; Drug Therapy, Combination; Humans; Patient Compliance; Platelet Activation; Thromboxane A2 | 2008 |
Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Drug Resistance; Humans; Platelet Aggregation; Thrombosis; Thromboxane A2 | 2008 |
Aspirin 'resistance': role of pre-existent platelet reactivity and correlation between tests.
Topics: Adult; Aspirin; Cyclooxygenase Inhibitors; Drug Resistance; Female; Humans; Male; Platelet Activation; Platelet Function Tests; Sensitivity and Specificity; Thromboxane A2; Young Adult | 2008 |
COX-1 sensitivity and thromboxane A2 production in type 1 and type 2 diabetic patients under chronic aspirin treatment.
Topics: Adult; Aged; Aspirin; Blood Platelets; C-Reactive Protein; Case-Control Studies; Cyclooxygenase 1; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Resistance; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Statistics, Nonparametric; Thromboxane A2 | 2009 |
Thromboxane A(2) promotes soluble CD40 ligand release from human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aged; Aspirin; Atherosclerosis; Blood Platelets; Carotid Artery Diseases; CD40 Ligand; Female; Humans; Male; MAP Kinase Kinase 4; Methacrylates; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrazoles; Ristocetin; Thromboxane A2 | 2010 |
Aspirin resistance with genetic dyslipidemia: contribution of vascular thromboxane generation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Apolipoproteins E; Arterioles; Aspirin; Blood Vessels; Drug Resistance; Dyslipidemias; Endothelium, Vascular; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, LDL; Thromboxane A2 | 2010 |
Simvastatin administration reduces thromboxane production in subjects taking aspirin: links between aspirin resistance and thrombin generation.
Topics: Aspirin; Cardiovascular Diseases; Drug Resistance; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation Inhibitors; Simvastatin; Thrombin; Thromboxane A2 | 2012 |
Influence of antiplatelet drugs in the pathogenesis of experimental periodontitis and periodontal repair in rats.
Topics: Alveolar Bone Loss; Animals; Aspirin; Blood Platelets; Bone Density; Bone Regeneration; Clopidogrel; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Interleukin-6; Leukocytes; Male; Mandibular Diseases; Periodontal Attachment Loss; Periodontitis; Periodontium; Platelet Activation; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Thromboxane A2; Ticlopidine; Time Factors; Tumor Necrosis Factor-alpha; Wound Healing; X-Ray Microtomography | 2011 |
Why an aspirin a day no longer keeps the doctor away ….
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Coronary Artery Disease; Drug Administration Schedule; Drug Monitoring; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Thromboxane A2; Time Factors; Treatment Outcome | 2011 |
24-hour time-dependent aspirin efficacy in patients with stable coronary artery disease.
Topics: Aged; Arachidonic Acid; Aspirin; Blood Platelets; Chi-Square Distribution; Coronary Artery Disease; Drug Administration Schedule; Drug Monitoring; Drug Resistance; Female; Humans; Male; Middle Aged; Odds Ratio; Paris; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Thromboxane A2; Time Factors; Treatment Outcome | 2011 |
In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Aspirin; Collagen; Drug Synergism; Epinephrine; Humans; In Vitro Techniques; Peptide Fragments; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thromboxane A2 | 2011 |
[Effect of aspirin on pulmonary hypertension in rat during chronic hypoxia and hypercapnia].
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Carotid Arteries; Epoprostenol; Hypercapnia; Hypertension, Pulmonary; Hypoxia; Male; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Thromboxane A2 | 2003 |
Residual cyclooxygenase-1 activity and epinephrine reduce the antiplatelet effect of aspirin in patients with acute myocardial infarction.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Platelets; Calcium Signaling; Cells, Cultured; Cyclooxygenase 1; Drug Interactions; Epinephrine; Female; Humans; Male; Middle Aged; Myocardial Infarction; Phosphatidylinositol 3-Kinases; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2 | 2011 |
BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apolipoproteins E; Aspirin; Atherosclerosis; Dinoprost; Drug Therapy, Combination; Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Mice; Mice, Knockout; Receptors, Thromboxane; Saphenous Vein; Sulfonylurea Compounds; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Vascular Cell Adhesion Molecule-1 | 2011 |
Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis.
Topics: Adenosine Diphosphate; Angiogenesis Modulating Agents; Aspirin; Blood Platelets; Breast Neoplasms; Carcinoma; Cells, Cultured; Endostatins; Endothelial Cells; Female; Humans; Models, Biological; Neovascularization, Pathologic; Neovascularization, Physiologic; Secretory Vesicles; Thromboxane A2; Vascular Endothelial Growth Factor A | 2011 |
Overcoming "aspirin resistance" in MPN.
Topics: Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Female; Humans; Male; Thrombocythemia, Essential; Thromboxane A2 | 2012 |
Predictors of thromboxane levels in patients with non-ST-elevation acute coronary syndromes on chronic aspirin therapy.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Biomarkers; Chronic Disease; Coronary Angiography; Electrocardiography; Female; Humans; Male; Middle Aged; Platelet Activation; Prognosis; Risk Factors; Thromboxane A2 | 2012 |
Measurements of thromboxane production and their clinical significance in coronary heart disease.
Topics: Acute Coronary Syndrome; Aspirin; Biomarkers; Female; Humans; Male; Thromboxane A2 | 2012 |
The effect of selected pre-analytical phase variables on plasma thromboxane A₂ measurements in humans.
Topics: Anticoagulants; Aspirin; Blood Platelets; Citrates; Cyclooxygenase Inhibitors; Humans; Immunoenzyme Techniques; Platelet Aggregation Inhibitors; Specimen Handling; Temperature; Thromboxane A2; Thromboxane B2; Time Factors | 2013 |
Investigation of piperidine derivatives in ex vivo models of pain and platelet aggregation.
Topics: Analgesics; Animals; Aspirin; Female; Humans; Inhibitory Concentration 50; Male; Mice; Pain; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins; Receptors, Opioid; Structure-Activity Relationship; Thromboxane A2 | 2012 |
Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma.
Topics: Animals; Aspirin; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Dendritic Cells; Disease Models, Animal; Disease Progression; Homozygote; Immunity, Innate; Inflammation; Macrophages; Mice; Mice, Transgenic; Neuroblastoma; Prostaglandin D2; Th2 Cells; Thromboxane A2; Transforming Growth Factor beta | 2013 |
Reduction of platelet cytosolic phospholipase A2 activity by atorvastatin and simvastatin: biochemical regulatory mechanisms.
Topics: Anticholesteremic Agents; Aspirin; Atorvastatin; Blood Platelets; Calcium; Collagen; Cyclooxygenase 1; Drug Combinations; Drug Synergism; Heptanoic Acids; Humans; Mitogen-Activated Protein Kinases; Phospholipase A2 Inhibitors; Phospholipases A2; Phosphorylation; Platelet Aggregation; Pravastatin; Pyrroles; Simvastatin; Thromboxane A2; Thromboxane-A Synthase | 2013 |
Microfluidic assay of platelet deposition on collagen by perfusion of whole blood from healthy individuals taking aspirin.
Topics: Administration, Oral; Adolescent; Adult; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 1; Female; Fluorescent Dyes; Humans; Male; Microfluidic Analytical Techniques; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reference Values; Regional Blood Flow; Signal Transduction; Stress, Mechanical; Thromboxane A2; Young Adult | 2013 |
Protection of vascular endothelium by aspirin in a murine model of chronic Chagas' disease.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Chagas Cardiomyopathy; Chronic Disease; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Male; Mice; Mice, Inbred BALB C; Parasitemia; Survival Analysis; Thromboxane A2 | 2013 |
TXA2 synthesis and COX1-independent platelet reactivity in aspirin-treated patients soon after acute cerebral stroke or transient ischaemic attack.
Topics: Acute Disease; Aged; Aspirin; Case-Control Studies; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Female; Humans; Ischemic Attack, Transient; Male; Platelet Aggregation; Stroke; Thromboxane A2 | 2013 |
The administration of a loading dose of aspirin to patients presenting with acute myocardial infarction while receiving chronic aspirin treatment reduces thromboxane A2-dependent platelet reactivity.
Topics: Aged; Aged, 80 and over; Aspirin; Biomarkers; Blood Platelets; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane A2 | 2014 |
Aspirin augments carotid-cardiac baroreflex sensitivity during muscle mechanoreflex and metaboreflex activation in humans.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arterial Pressure; Aspirin; Baroreflex; Chemoreceptor Cells; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Female; Heart Rate; Humans; Isometric Contraction; Male; Mechanoreceptors; Mechanotransduction, Cellular; Muscle, Skeletal; Reflex, Stretch; Thromboxane A2; Thromboxane B2; Time Factors | 2013 |
Various laboratory protocols for measuring thromboxane A2 generation to detect the effectiveness of acetylsalicylic acid therapy: a comparative study.
Topics: Adult; Aspirin; Blood Chemical Analysis; Blood Coagulation; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2 | 2014 |
Fatty acids and TxA(2) generation, in the absence of platelet-COX-1 activity.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Cardiovascular Diseases; Chromatography, Liquid; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Fatty Acids, Omega-3; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; Smoking; Tandem Mass Spectrometry; Thromboxane A2; Thromboxane B2 | 2014 |
Alditols and monosaccharides from sorghum vinegar can attenuate platelet aggregation by inhibiting cyclooxygenase-1 and thromboxane-A2 synthase.
Topics: Acetic Acid; Adult; Arachidonic Acid; Aspirin; Cyclooxygenase 1; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; In Vitro Techniques; Molecular Docking Simulation; Monosaccharides; Plant Extracts; Platelet Aggregation Inhibitors; Sorghum; Sugar Alcohols; Thromboxane A2; Thromboxane-A Synthase; Young Adult | 2014 |
Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors.
Topics: Allergens; Animals; Aspirin; Asthma; Blood Platelets; Bone Marrow Transplantation; Bronchoalveolar Lavage Fluid; Cysteine; Eosinophilia; Inflammation; Intercellular Adhesion Molecule-1; Leukotriene Antagonists; Leukotriene C4; Leukotrienes; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Platelet Activation; Receptors, Prostaglandin; Thromboxane A2; Vascular Cell Adhesion Molecule-1 | 2015 |
Circulating primers enhance platelet function and induce resistance to antiplatelet therapy.
Topics: Adenosine Triphosphate; Aspirin; Autoantigens; Biomarkers; Blood Coagulation; Blood Platelets; CD36 Antigens; Drug Resistance; Epinephrine; Humans; Insulin-Like Growth Factor I; Iodide Peroxidase; Iron-Binding Proteins; Phosphatidylinositol 3-Kinase; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase Inhibitors; Purinergic P2Y Receptor Antagonists; Receptor, PAR-1; Thromboxane A2 | 2015 |
In Vivo Platelet Activation and Aspirin Responsiveness in Type 1 Diabetes.
Topics: Adult; Albuminuria; Aspirin; Blood Glucose; Cross-Sectional Studies; Cyclooxygenase 1; Diabetes Mellitus, Type 1; Dinoprost; Epoprostenol; Female; Humans; Male; Matched-Pair Analysis; Microvessels; Middle Aged; Oxidative Stress; Platelet Activation; Platelet Aggregation Inhibitors; Sex Factors; Thromboxane A2 | 2016 |
Platelet Dysfunction in Type 1 Diabetes: Stressing the Thromboxanes.
Topics: Aspirin; Diabetes Mellitus, Type 1; Epoprostenol; Female; Humans; Male; Platelet Activation; Platelet Aggregation Inhibitors; Thromboxane A2 | 2016 |
A novel thromboxane receptor antagonist, nstpbp5185, inhibits platelet aggregation and thrombus formation in animal models.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Aspirin; Benzimidazoles; Blood Platelets; Calcium; Collagen; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Microvessels; P-Selectin; Platelet Aggregation; Pulmonary Embolism; Receptors, Thromboxane A2, Prostaglandin H2; Thrombosis; Thromboxane A2 | 2016 |
Evaluation on antithrombotic effect of aspirin eugenol ester from the view of platelet aggregation, hemorheology, TXB2/6-keto-PGF1α and blood biochemistry in rat model.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Aspirin; Blood Chemical Analysis; Eugenol; Fibrinolytic Agents; Hemorheology; Male; Platelet Aggregation; Rats; Rats, Wistar; Thrombosis; Thromboxane A2 | 2016 |
Effect of Compound Sbt-828, a New Indole Derivative Exhibiting Antiaggregant Activity, on the Prostacyclin-Thromboxane A
Topics: Animals; Animals, Outbred Strains; Aorta, Abdominal; Aspirin; Blood Platelets; Epinephrine; Epoprostenol; Indoles; Injections, Intravenous; Lethal Dose 50; Male; Malondialdehyde; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Thrombin; Thromboxane A2; Tissue Culture Techniques | 2017 |
Lack of Bioequivalence Among Low-dose, Enteric-coated Aspirin Preparations.
Topics: Arachidonic Acid; Aspirin; Dose-Response Relationship, Drug; Humans; Peptide Fragments; Platelet Aggregation Inhibitors; Tablets, Enteric-Coated; Therapeutic Equivalency; Thromboxane A2 | 2018 |
Prevalence of high on-treatment (aspirin and clopidogrel) platelet reactivity in patients with critical limb ischemia.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Critical Illness; Drug Therapy, Combination; Female; Humans; Ischemia; Male; Microfilament Proteins; Middle Aged; Peripheral Arterial Disease; Phosphoproteins; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thromboxane A2; Time Factors; Treatment Outcome | 2018 |
Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A
Topics: Aged; Aspirin; Cardiovascular Agents; Cardiovascular Diseases; Carrier Proteins; Contactins; Europe; Female; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Genome-Wide Association Study; Haplotypes; Humans; Incidence; Male; Middle Aged; Multicenter Studies as Topic; Phenotype; Polymorphism, Single Nucleotide; Primary Prevention; Progression-Free Survival; Randomized Controlled Trials as Topic; Risk Factors; RNA-Binding Proteins; Thromboxane A2; Thromboxane B2; Time Factors; White People | 2018 |
Molecular mechanisms of platelet activation and aggregation induced by breast cancer cells.
Topics: Amino Acid Chloromethyl Ketones; Aspirin; Blood Platelets; Breast Neoplasms; Caco-2 Cells; Calcium Chloride; Colorectal Neoplasms; Female; Fibrin; Fibrinogen; Humans; Integrin alpha2; MCF-7 Cells; Platelet Activation; Platelet Aggregation; Thromboxane A2; Type C Phospholipases | 2018 |
Genistein Ameliorates Non-alcoholic Fatty Liver Disease by Targeting the Thromboxane A
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Diet, High-Fat; Disease Models, Animal; Disease Progression; Genistein; Hep G2 Cells; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 2018 |
A prophylactic low-dose aspirin earlier than 12 weeks until delivery should be considered to prevent preeclampsia.
Topics: Anti-Inflammatory Agents; Aspirin; Endothelium, Vascular; Epoprostenol; Female; Humans; Obstetrics; Placenta; Placentation; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Risk; Thromboxane A2 | 2018 |
Aspirin eugenol ester inhibits agonist-induced platelet aggregation in vitro by regulating PI3K/Akt, MAPK and Sirt 1/CD40L pathways.
Topics: Animals; Aspirin; Calcium; Caspase 3; CD40 Ligand; Cell Adhesion Molecules; Cyclic AMP; Cyclic GMP; Eugenol; Gene Expression Regulation; Intracellular Space; L-Lactate Dehydrogenase; Male; MAP Kinase Signaling System; Microfilament Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Platelet Aggregation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Sirtuin 1; Thromboxane A2 | 2019 |
Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk.
Topics: Adult; Aspirin; Blood Coagulation; Blood Platelets; Computer Simulation; Cross-Sectional Studies; Drug Monitoring; Female; Hemorrhage; Humans; Male; Microfluidics; Middle Aged; Myosins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Prognosis; Thromboxane A2; Wounds and Injuries | 2019 |
Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cell Line, Tumor; Cyclooxygenase Inhibitors; Female; Humans; Lung Neoplasms; Macrophages; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Monocytes; Neoplasm Metastasis; Neoplasm Transplantation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins; Protein Isoforms; Thrombosis; Thromboxane A2 | 2019 |
UPLC-Q-TOF/MS-Based Plasma Metabolomics to Evaluate the Effects of Aspirin Eugenol Ester on Blood Stasis in Rats.
Topics: Animals; Aspirin; Blood; Blood Chemical Analysis; Blood Coagulation; Blood Viscosity; Chromatography, High Pressure Liquid; Disease Models, Animal; Epoprostenol; Eugenol; Female; Hematologic Diseases; Metabolomics; Platelet Aggregation; Rats; Thromboxane A2 | 2019 |
Canine platelets express functional Toll-like receptor-4: lipopolysaccharide-triggered platelet activation is dependent on adenosine diphosphate and thromboxane A2 in dogs.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Dogs; Lipopolysaccharides; Platelet Activation; Rhodobacter sphaeroides; Thromboxane A2; Toll-Like Receptor 4 | 2019 |
Aspirin Reduces the Potentiating Effect of CD40L on Platelet Aggregation via Inhibition of Myosin Light Chain.
Topics: Aspirin; Blood Platelets; CD40 Ligand; Humans; Myosin Light Chains; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Signal Transduction; Thromboxane A2 | 2020 |
Identification of a homozygous recessive variant in
Topics: Aspirin; Blood Platelets; Cyclooxygenase 1; Female; Humans; Platelet Aggregation; Platelet Function Tests; Thromboxane A2 | 2021 |
Persistent long-term platelet activation and endothelial perturbation in women with Takotsubo syndrome.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Case-Control Studies; Citrulline; Endothelium, Vascular; Female; Humans; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Takotsubo Cardiomyopathy; Thrombomodulin; Thromboxane A2; Time Factors | 2021 |
The Protective Effect of Aspirin against Myocardial Hypertrophy in Rats.
Topics: Animals; Apoptosis; Aspirin; Blood Pressure; Body Weight; Cardiotonic Agents; Disease Models, Animal; Fibrillar Collagens; Heart Ventricles; Hypertrophy; Inflammation Mediators; Interleukin-10; Male; Myocardium; Myocytes, Cardiac; Organ Size; Prostaglandins; Rats, Wistar; Thromboxane A2; Tumor Necrosis Factor-alpha | 2021 |
Low-dose Aspirin prevents hypertension and cardiac fibrosis when thromboxane A
Topics: Adult; Animals; Antifibrotic Agents; Antihypertensive Agents; Aspirin; Biomarkers; Blood Platelets; Blood Pressure; Cardiomyopathies; Case-Control Studies; Cells, Cultured; Disease Models, Animal; Essential Hypertension; Female; Fibrosis; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Myocytes, Cardiac; Myofibroblasts; Platelet Aggregation Inhibitors; Receptors, Epoprostenol; Receptors, Thromboxane; Thromboxane A2 | 2021 |
Urinary Thromboxane B2 and Lethal Prostate Cancer in African American Men.
Topics: Aspirin; Black or African American; Humans; Male; Prostatic Neoplasms; Thromboxane A2; Thromboxane B2 | 2022 |
Platelet Inhibition by Low-Dose Acetylsalicylic Acid Reduces Neuroinflammation in an Animal Model of Multiple Sclerosis.
Topics: Animals; Aspirin; Blood Platelets; Brain; CD4-Positive T-Lymphocytes; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Inflammation; Mice, Inbred C57BL; Multiple Sclerosis; Platelet Aggregation Inhibitors; Thromboxane A2 | 2021 |
Comparative study on the effect of aspirin, TP receptor antagonist and TxA
Topics: Arachidonic Acid; Aspirin; Benzofurans; Carbazoles; Enzyme Inhibitors; Female; Humans; Male; Mammary Arteries; Muscle, Smooth, Vascular; Phenylephrine; Receptors, Prostaglandin; Receptors, Thromboxane; Saphenous Vein; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction | 2021 |
Aspirin suppresses breast cancer metastasis to lung by targeting anoikis resistance.
Topics: Animals; Anoikis; Aspirin; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Lung; Lung Neoplasms; Mice; Neoplasm Metastasis; Neoplasms, Second Primary; Signal Transduction; Thromboxane A2 | 2022 |
Utility of constraints reflecting system stability on analyses for biological models.
Topics: Algorithms; Anti-Inflammatory Agents; Arachidonic Acid; Aspirin; Models, Biological; NF-kappa B; Prostaglandins I; Thromboxane A2 | 2022 |
Aspirin Suppresses Hepatic Glucagon Signaling Through Decreasing Production of Thromboxane A2.
Topics: Aspirin; Diabetes Mellitus; Glucagon; Gluconeogenesis; Glucose; Humans; Hyperglycemia; Hypoglycemic Agents; Liver; Thromboxane A2 | 2023 |
It's Not Just for Pain: A New Metabolic Function of Aspirin.
Topics: Aspirin; Glucagon; Humans; Pain; Thromboxane A2 | 2023 |
Cyclooxygenases and platelet functions.
Topics: Aspirin; Cyclooxygenase 2; Humans; Prostaglandin H2; Prostaglandins; Thromboxane A2 | 2023 |