aspirin has been researched along with simvastatin in 113 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (8.85) | 18.2507 |
| 2000's | 35 (30.97) | 29.6817 |
| 2010's | 62 (54.87) | 24.3611 |
| 2020's | 6 (5.31) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Harada, T; Nakagawa, Y; Potter, PM; Wadkins, RM; Wheelock, CE | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bharate, SS; Vishwakarma, RA | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Averna, M; Barbagallo, C; Catalano, I; Ciabattoni, G; Davì, G; Ganci, A; Notarbartolo, A; Patrono, C | 1 |
| Buja, LM; Casscells, SW; Goff, DC; Gould, KL | 1 |
| Aumont, MC; Seknadji, P | 1 |
| Savege, P; Sheridan, P; Silverman, S | 1 |
| Butler, R; MacDonald, TM; Morris, AD; Newton, RW | 1 |
| Cleland, JG; Walker, A | 1 |
| Cook, T; Faergeman, O; Kjekshus, J; Pedersen, TR; Pyörälä, K; Thorgeirsson, G; Wilhelmsen, L | 1 |
| Ferner, RE | 1 |
| Gajewski, P; Góra, P; Jankowski, M; Musiał, J; Swadźba, J; Szczeklik, A; Undas, A | 1 |
| Ferguson, JJ | 1 |
| Bloomfield, P; Boyd, J; Irving, RJ; McRae, F; Oram, SH; Rutledge, P | 1 |
| Hildebrandt, PR; Melchior, TM; Seibaek, MB; Snorgaard, O; Torp-Pedersen, CT | 1 |
| Isles, CG; Paterson, JR | 1 |
| Gajewski, P; Jankowski, M; Musial, J; Sydor, W; Szczeklik, A; Undas, A | 1 |
| Brozek, J; Musiał, J; Szczeklik, A; Undas, A; Undas, R | 1 |
| Fox, R | 1 |
| Fonarow, GC | 1 |
| George, A; Shakib, S | 1 |
| Ito, MK; Pieper, JA; Talbert, RL | 1 |
| Diener, HC | 1 |
| Basili, S; Cardarello, CM; Davi, G; Ferroni, P; Gazzaniga, PP; Martini, F | 1 |
| Fang, CH; Li, JJ | 1 |
| Kopff, A; Kopff, M; Kowalczyk, E | 1 |
| Altmann, P; Armitage, J; Baigent, C; Baxter, A; Cairns, HS; Collins, R; Foley, RN; Frighi, V; Kourellias, K; Landray, M; Leaper, C; Ratcliffe, PJ; Rogerson, M; Scoble, JE; Tomson, CR; Warwick, G; Wheeler, DC | 1 |
| Krane, V; Wanner, C | 1 |
| Antonopoulos, S; Filioti, K; Giannoulis, G; Karamanolis, D; Kokkoris, S; Mikros, S; Protopsaltis, J | 1 |
| Bruce, IN | 1 |
| Arutiunov, GP; Daĭter, II; Kartseva, TP; Malanichev, RV; Marfunina, AA; Nakhaev, VI; Rozanov, AV; Rylova, AK; Stepanova, LV; Voevodina, NIu | 1 |
| Bajraktari, G; Beqiri, A; Berisha, I; Elezi, S; Kastrati, S; Manaj, R; Thaqi, S | 1 |
| Grond, M | 1 |
| Kanorskiĭ, SG; Shevelev, VI; Zafiraki, VK; Zingilevskiĭ, KB | 1 |
| Buchan, AM; Demchuk, AM; Eliasziw, M; Hill, MD; Kennedy, J; Ryckborst, KJ | 1 |
| Berlion, AE; Morkel, H; Smedema, JP | 1 |
| Kumar, V; Shah, RP; Singh, S | 1 |
| Xiao, H; Yang, CS | 1 |
| Sundermeyer, M; Veeraputhiran, M | 1 |
| Afzal, R; Pais, P; Pogue, J; Sigamani, A; Xavier, D; Yusuf, S | 1 |
| Bläuer, M; Murtola, TJ; Pennanen, P; Syvälä, H; Tammela, TL; Ylikomi, T | 1 |
| Afzal, R; Eikelboom, J; Gupta, R; Mohan, V; Pais, P; Sigamani, A; Teo, K; Thomas, N; Xavier, D; Yusuf, S | 1 |
| Brummel-Ziedins, K; Mann, KG; Siudak, Z; Tracz, W; Undas, A | 1 |
| Buerke, M; Chen, L; Frister, A; Hofmann, B; Lautenschläger, M; Loppnow, H; Luther, T; Müller-Werdan, U; Rose-John, S; Schlitt, A; Silber, RE; Song, N; Werdan, K; Zhang, L | 1 |
| Chakraborty, BS; Desai, J; Ghosh, C; Jha, V; Khamar, B; Patel, A; Shah, G; Shah, T | 1 |
| Eckel, RH | 1 |
| Adámek, T; Alusik, S; Lejsková, M; Paluch, Z | 1 |
| Hwang, DY; Pless, ML | 1 |
| Birnbaum, Y; Long, B; Perez-Polo, JR; Qian, J; Ye, Y | 1 |
| Baker, M; Gupta, A; Maguire, M; Muwanga, C; Seidi, O | 1 |
| Berk, M; Henry, MJ; Jacka, FN; Kotowicz, MA; Nicholson, GC; Pasco, JA; Williams, LJ | 1 |
| Casulari, LA; Dos Santos, AM; Salgado, BJ; Salgado, JV | 1 |
| Birnbaum, Y; Perez-Polo, JR; Ye, Y | 1 |
| Leśniak, M; Siudak, Z; Topór-Mądry, R; Tracz, W; Undas, A | 1 |
| Al-Naamani, N; Bagiella, E; Barr, RG; Girgis, R; Hassoun, P; Horn, EM; Kawut, SM; Lederer, DJ; Post, W; Roberts, KE; Shimbo, D; Tracy, R | 1 |
| Dissanayake, WP; Furberg, CD; Gunaratne, PS; Jayasingne, IK; Mendis, S; Soliman, EZ; Somasundaram, NP | 1 |
| Ahn, BJ; Chae, HS; Choi, J; Doh, K; Han, S; Jun, YK; Kim, J; Lee, YW; Yim, DS | 1 |
| Malmioja, K; Peura, L; Rautio, J | 1 |
| de Leeuw, FE; van Deuren, M; van Dijk, EJ; van Gaalen, J | 1 |
| Bagiella, E; Barr, RG; Girgis, RE; Hassoun, PM; Hill, NS; Horn, EM; Kawut, SM; Lederer, DJ; Palevsky, HI; Post, W; Roberts, KE; Rosenzweig, EB; Shimbo, D; Tracy, RP | 1 |
| Rich, S | 1 |
| Barreiro-de-Acosta, M; Campos-Franco, J; Losada-Ares, L; Pérez-Pampín, E | 1 |
| Luzak, B; Rywaniak, J; Stanczyk, L; Watala, C | 1 |
| Carey, KM; Comee, MR; Donovan, JL; Kanaan, AO | 1 |
| Afzal, R; Gao, P; Pais, P; Sigamani, A; Teo, KK; Xavier, D; Yusuf, S | 1 |
| Chia, PL; Lee, E | 1 |
| Darshan, J; Gadola, SD; Gallagher, PJ; Green, B; Shaw, E | 1 |
| Bautista, LE; Casas, JP; Chirinos, JA; Ferrante, D; Ferreccio, C; Herrera, VM; Medina-Lezama, J; Miranda, JJ; Oróstegui Arenas, M; Pérez, CM; Pichardo, R; Sánchez Abanto, JR; Schapochnik, N; Silva, E; Vera-Cala, LM | 1 |
| Chee, FY; How, CH | 1 |
| Latorre, A; Madrid, I; Moscardó, A; Santos, MT; Vallés, J | 1 |
| Bots, ML; Grobbee, DE; Lafeber, M; Rodgers, A; Spiering, W; Thom, S; Visseren, FL; Webster, R | 1 |
| Ademi, Z; Liew, D; Magliano, DJ; Owen, A; Reid, CM; Zomer, E | 1 |
| Cohn, S; Deller, R; Edwards, D; Fletcher, K; Giles, M; Hobbs, V; Lasserson, D; Mant, J; McGuire, G; McManus, R; Norrie, J; Sims, D; Weir, C; Whittle, F | 1 |
| Billot, L; Bompoint, S; Bots, ML; Cidambi, R; Field, J; Grobbee, DE; Patel, A; Poulter, N; Prabhakaran, D; Reddy, KS; Rodgers, A; Stanton, A; Thom, S | 1 |
| Al-Gayyar, MM; El-Gayar, AM; Hassan, HM; Ibrahim, TM | 1 |
| Absi, M; Bruce, JI; Ward, DT | 1 |
| Beattie, D; Burkes, M; Cruickshank, R; Smith, L | 1 |
| Golden, SH; Joseph, JJ | 1 |
| Billot, L; Bompoint, S; Brown, A; Burch, C; Burke, H; Cass, A; Hayman, N; Hillis, GS; Jan, S; Molanus, B; Neal, B; Patel, A; Peiris, D; Rafter, N; Reid, CM; Rodgers, A; Shiel, L; Togni, S; Tonkin, A; Usherwood, T; Webster, R | 1 |
| Barbosa, SP; Bianco, HT; Camargo, LM; Fonseca, FA; França, CN; Izar, MC; Lins, LS; Pinheiro, LF | 1 |
| Bharucha, AE; Carlson, DA; Choi, KM; Farrugia, GF; Gibbons, SJ; Saw, JJ; Zinsmeister, AR | 1 |
| Ahmed, FR; Khan, MA; Manzoor, S; Nasiri, MI; Salam, FA; Shoaib, MH; Sultan, F; Yousuf, RI | 1 |
| Agmadova, ZM; Kallaeva, AN | 1 |
| Archer-Chicko, C; Bagiella, E; Girgis, RE; Hassoun, PM; Horn, EM; Kawut, SM; Lederer, DJ; Mathai, SC; Matura, LA; Palevsky, HI; Pinder, D; Roberts, KE; Tracy, RP; Ventetuolo, CE | 1 |
| Bourre, B; Lefaucheur, R; Maltête, D; Ozkul-Wermester, O; Wallon, D | 1 |
| Karam, I; Kong, XJ; Li, JY; Li, SH; Liu, XW; Ma, N; Yang, YJ | 1 |
| Cipollone, F; Creemers, EE; de Ronde, MW; Halliani, A; Kok, MG; Mandolini, C; Meijers, JC; Moerland, PD; Nieuwland, R; Pinto-Sietsma, SJ; Sondermeijer, BM | 1 |
| Barrios, V; Escobar, C | 1 |
| Lozano, I; Rondan, J; Sanchez, LI; Segovia, E; Vega, B; Vegas, JM | 1 |
| Luteijn, JM; Morris, JK; Oppenheimer, P; Taylor, D; Wald, NJ | 1 |
| Davidson, M; Nilsson, C; Offman, E | 1 |
| Bots, ML; Grobbee, DE; Lafeber, M; Patel, A; Prabhakaran, D; Rodgers, A; Spiering, W; Stanton, A; Thom, S; Visseren, FL; Webster, R | 1 |
| Cheruvu, HS; Devalapalli, MMR; Sampathi, S; Shivakumar, S; Veeravalli, VB; Yertha, T | 1 |
| Ahern, TP; Christiansen, P; Cronin-Fenton, D; Damkier, P; Ejlertsen, B; Lash, TL; Sørensen, HT | 1 |
| Cao, J; Fan, L; Hao, WJ; Ke, SZ; Li, JH; Liu, L; Luo, XX; Sun, YF | 1 |
| Almajaan, A; Andrews, GP; Healy, A; Jones, DS; Li, S; Martini, L; Yu, T | 1 |
| Campos-Estrada, C; Carillo, I; Castillo, C; González-Herrera, F; Greif, G; Guzmán-Rivera, D; Kemmerling, U; Liempi, A; Maya, JD; Robello, C | 1 |
| Abdelfattah, U; Elbanoby, T; Hong, JPJ; Kim, EN; Park, EJ; Suh, HP | 1 |
| Abdulwahab, S; Eissa, MS; Elsonbaty, A; Hassan, WS; Serag, A | 1 |
| Keikhosravi, N; Mirdamadian, SZ; Taheri, A; Varshosaz, J | 1 |
| Bosch, J; Christou, C; Dagenais, G; Dans, A; Gamra, H; Gao, P; Girish, P; Joseph, P; López-Jaramillo, P; McCready, T; Pais, P; Rocha, C; Santoso, A; Talukder, S; Teo, K; Tyrwhitt, J; Xavier, D; Xavier, F; Yeates, K; Yusoff, K; Yusuf, S | 1 |
| Huangtao, Z; Li, B; Liu, T; Pan, Y; Sun, L; Wang, B; Wang, J; Wang, S; Zhu, Z; Zuo, R | 1 |
16 review(s) available for aspirin and simvastatin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Secondary prevention after myocardial infarction; rôle of platelet antiaggregants and hypolipemic agents].
Topics: Anticholesteremic Agents; Aspirin; Coronary Disease; Cost-Benefit Analysis; Gemfibrozil; Humans; Hypolipidemic Agents; Lovastatin; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Simvastatin | 1996 |
Which drugs benefit diabetic patients for secondary prevention of myocardial infarction? DARTS/MEMO Collaboration.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Diabetes Complications; Humans; Hypolipidemic Agents; Myocardial Infarction; Simvastatin | 1998 |
Therapeutic options and cost considerations in the treatment of ischemic heart disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Coronary Artery Bypass; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Models, Economic; Myocardial Ischemia; Quality-Adjusted Life Years; Simvastatin | 1998 |
[Treatment of diabetic patients with ischaemic heart disease].
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Diabetes Complications; Diabetes Mellitus; Humans; Hypolipidemic Agents; Metabolic Diseases; Myocardial Ischemia; Simvastatin; Thrombolytic Therapy | 2000 |
Identifying patients at risk for coronary heart disease: implications from trials of lipid-lowering drug therapy.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Bezafibrate; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Dietary Supplements; Female; Fibrinolytic Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Life Style; Male; Middle Aged; Niacin; Patient Selection; Ramipril; Randomized Controlled Trials as Topic; Risk Factors; Simvastatin; Triglycerides | 2000 |
Aggressive treatment of atherosclerosis: the time is now.
Topics: Aspirin; Coronary Artery Disease; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Simvastatin | 2003 |
Choosing a drug from within a class.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Aspirin; Australia; Decision Making; Drug Costs; Drug Therapy, Combination; Drug Utilization; Drugs, Generic; Family Practice; Female; Humans; Hypertension; Indoles; Myocardial Infarction; Practice Patterns, Physicians'; Severity of Illness Index; Simvastatin | 2003 |
Cardiovascular disease in lupus patients: should all patients be treated with statins and aspirin?
Topics: Animals; Aspirin; Cardiovascular Diseases; Cyclooxygenase Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lupus Erythematosus, Systemic; Simvastatin; Treatment Outcome | 2005 |
Combination regimen with statins and NSAIDs: a promising strategy for cancer chemoprevention.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Atorvastatin; Celecoxib; Colorectal Neoplasms; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Evidence-Based Medicine; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Meta-Analysis as Topic; Neoplasms; Pravastatin; Pyrazoles; Pyridines; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin; Sulfonamides; Sulindac | 2008 |
Protecting against ischemia-reperfusion injury: antiplatelet drugs, statins, and their potential interactions.
Topics: Aspirin; Cilostazol; Dipyridamole; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Models, Cardiovascular; Myocardial Infarction; Myocardial Reperfusion Injury; Platelet Aggregation Inhibitors; Simvastatin; Tetrazoles | 2010 |
[Prodrug technology in the development of medicinal agents].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aspirin; Clopidogrel; Drug Delivery Systems; Drug Design; Humans; Lansoprazole; Oseltamivir; Prodrugs; Simvastatin; Ticlopidine | 2011 |
A polypill for all? Critical review of the polypill literature for primary prevention of cardiovascular disease and stroke.
Topics: Antihypertensive Agents; Aspirin; Atenolol; Cardiovascular Diseases; Drug Combinations; Humans; Hydrochlorothiazide; Hypolipidemic Agents; Platelet Aggregation Inhibitors; Primary Prevention; Ramipril; Simvastatin; Stroke | 2012 |
Type 2 diabetes and cardiovascular disease: what next?
Topics: Anticholesteremic Agents; Aspirin; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Therapy, Combination; Exercise; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Obesity; Risk Factors; Risk Reduction Behavior; Simvastatin; Sleep Wake Disorders; Socioeconomic Factors; Stress, Psychological | 2014 |
Improving cardiovascular protection: focus on a cardiovascular polypill.
Topics: Antihypertensive Agents; Aspirin; Atorvastatin; Cardiovascular Diseases; Drug Combinations; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Medication Adherence; Platelet Aggregation Inhibitors; Ramipril; Simvastatin | 2016 |
Long-term antiplatelet therapy with the polypill after stenting: More information is necessary.
Topics: Aged; Aspirin; Coronary Thrombosis; Drug Administration Schedule; Drug Combinations; Humans; Male; Platelet Aggregation Inhibitors; Ramipril; Simvastatin; Stents | 2016 |
27 trial(s) available for aspirin and simvastatin
| Article | Year |
|---|---|
Differences in the treatment of coronary heart disease between countries as revealed in the Scandinavian Simvastatin Survival Study (4S)
Topics: Angiotensin-Converting Enzyme Inhibitors; Anticholesteremic Agents; Aspirin; Calcium Channel Blockers; Cause of Death; Coronary Disease; Female; Finland; Follow-Up Studies; Humans; Iceland; Male; Middle Aged; Myocardial Revascularization; Prognosis; Scandinavian and Nordic Countries; Simvastatin; Survival Rate; Warfarin | 1998 |
Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia.
Topics: Adult; Aspirin; Biomarkers; Cholesterol; Drug Synergism; Drug Therapy, Combination; Fibrinopeptide A; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Peptide Fragments; Platelet Aggregation Inhibitors; Prognosis; Prothrombin; Safety; Simvastatin; Thrombin; Triglycerides | 1999 |
Treatment with simvastatin and low-dose aspirin depresses thrombin generation in patients with coronary heart disease and borderline-high cholesterol levels.
Topics: Adult; Aged; Aspirin; Cholesterol; Coronary Disease; Drug Therapy, Combination; Hemostatics; Humans; Hypolipidemic Agents; Male; Middle Aged; Peptide Fragments; Platelet Aggregation Inhibitors; Prothrombin; Simvastatin; Thrombin | 2001 |
Enhanced interleukin-1beta in hypercholesterolemia: effects of simvastatin and low-dose aspirin.
Topics: Adult; Aged; Aspirin; Female; Humans; Hypercholesterolemia; Interleukin-1; Male; Middle Aged; Platelet Aggregation Inhibitors; Simvastatin | 2003 |
First United Kingdom Heart and Renal Protection (UK-HARP-I) study: biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease.
Topics: Adult; Aged; Alanine Transaminase; Aspirin; Cardiovascular Diseases; Cholesterol, LDL; Chronic Disease; Creatine Kinase; Creatine Kinase, MM Form; Creatinine; Diabetic Nephropathies; Disease Progression; Feasibility Studies; Female; Hemorrhage; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Isoenzymes; Kidney Diseases; Kidney Transplantation; Lipids; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Renal Dialysis; Renal Replacement Therapy; Simvastatin; Single-Blind Method; Thrombophilia; Treatment Outcome | 2005 |
[Effects of aggressive therapy with simvastatin in patients with acute coronary syndrome and initially normal level of LDLP cholesterol on cardiovascular outcomes (LAOKOON). Pilot randomized trial].
Topics: Acute Disease; Aged; Anti-Inflammatory Agents; Aspirin; C-Reactive Protein; Cholesterol, LDL; Coronary Disease; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pilot Projects; Simvastatin; Syndrome; Treatment Outcome | 2005 |
[Prevention of ischemic stroke in middle aged patients with atrial fibrillation. Effect of sinus rhythm maintenance, aspirin, warfarin, and simvastatin].
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Brain Ischemia; Drug Therapy, Combination; Echocardiography; Electrocardiography; Female; Follow-Up Studies; Heart Rate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Contraction; Platelet Aggregation Inhibitors; Simvastatin; Sinoatrial Node; Treatment Outcome; Warfarin | 2007 |
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Ischemic Attack, Transient; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Risk Reduction Behavior; Secondary Prevention; Severity of Illness Index; Simvastatin; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
The need to test the theories behind the Polypill: rationale behind the Indian Polycap Study.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Atenolol; Capsules; Cardiovascular Agents; Cardiovascular Diseases; Diuretics; Double-Blind Method; Drug Combinations; Drug Costs; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; India; Platelet Aggregation Inhibitors; Primary Prevention; Ramipril; Research Design; Secondary Prevention; Simvastatin; Treatment Outcome | 2009 |
Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS): a phase II, double-blind, randomised trial.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aspirin; Atenolol; Cardiovascular Diseases; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; India; Middle Aged; Platelet Aggregation Inhibitors; Ramipril; Risk Factors; Risk Reduction Behavior; Simvastatin; Treatment Outcome | 2009 |
Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures.
Topics: Aspirin; Atorvastatin; Cell Separation; Coculture Techniques; Dose-Response Relationship, Drug; Drug Synergism; Heptanoic Acids; HMGB1 Protein; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indomethacin; Interleukin-1; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pyrroles; Recombinant Proteins; Simvastatin; STAT3 Transcription Factor; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Preservation of bioavailability of ingredients and lack of drug-drug interactions in a novel five-ingredient polypill (polycap): a five-arm phase I crossover trial in healthy volunteers.
Topics: Administration, Oral; Adolescent; Adult; Antihypertensive Agents; Area Under Curve; Aspirin; Atenolol; Biological Availability; Capsules; Cardiovascular Diseases; Chromatography, Liquid; Cross-Over Studies; Drug Combinations; Drug Interactions; Humans; Hydrochlorothiazide; Hypolipidemic Agents; Male; Middle Aged; Platelet Aggregation Inhibitors; Ramipril; Risk Factors; Simvastatin; Tandem Mass Spectrometry; Young Adult | 2010 |
Effects of low-dose of niacin associated to simvastatin in the treatment of mixed dyslipidemia Salgad.
Topics: Aged; Aspirin; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Drug Combinations; Dyslipidemias; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Male; Metabolic Syndrome; Middle Aged; Niacin; Platelet Aggregation Inhibitors; Prospective Studies; Simvastatin; Vasodilator Agents | 2010 |
Rationale and design of a phase II clinical trial of aspirin and simvastatin for the treatment of pulmonary arterial hypertension: ASA-STAT.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; C-Reactive Protein; Data Interpretation, Statistical; Double-Blind Method; Familial Primary Pulmonary Hypertension; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; P-Selectin; Quality of Life; Randomized Controlled Trials as Topic; Simvastatin; Treatment Outcome | 2011 |
A Polypill for primary prevention of cardiovascular disease: a feasibility study of the World Health Organization.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Attitude of Health Personnel; Biomarkers; Blood Pressure; Cardiovascular Agents; Cardiovascular Diseases; Chi-Square Distribution; Cholesterol; Diuretics; Drug Combinations; Feasibility Studies; Female; Health Knowledge, Attitudes, Practice; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lisinopril; Male; Medication Adherence; Middle Aged; Platelet Aggregation Inhibitors; Primary Prevention; Risk Assessment; Risk Factors; Simvastatin; Sri Lanka; Surveys and Questionnaires; Time Factors; Treatment Outcome; World Health Organization | 2011 |
Randomized clinical trial of aspirin and simvastatin for pulmonary arterial hypertension: ASA-STAT.
Topics: Adult; Aspirin; Cholesterol; Double-Blind Method; Drug Therapy, Combination; Endothelium, Vascular; Exercise Tolerance; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Retrospective Studies; Simvastatin; Treatment Outcome; Walking | 2011 |
Comparison of risk factor reduction and tolerability of a full-dose polypill (with potassium) versus low-dose polypill (polycap) in individuals at high risk of cardiovascular diseases: the Second Indian Polycap Study (TIPS-2) investigators.
Topics: Administration, Oral; Aged; Analysis of Variance; Antihypertensive Agents; Aspirin; Atenolol; Biomarkers; Blood Pressure; Capsules; Cardiovascular Diseases; Cholesterol, LDL; Creatinine; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Female; Heart Rate; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; India; Male; Middle Aged; Platelet Aggregation Inhibitors; Polypharmacy; Potassium; Ramipril; Risk Assessment; Risk Factors; Simvastatin; Tablets; Time Factors; Treatment Outcome | 2012 |
The evening versus morning polypill utilization study: the TEMPUS rationale and design.
Topics: Administration, Oral; Antihypertensive Agents; Aspirin; Biomarkers; Blood Platelets; Blood Pressure; Cardiovascular Diseases; Cholesterol, LDL; Clinical Protocols; Cross-Over Studies; Drug Chronotherapy; Drug Combinations; Dyslipidemias; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Lisinopril; Netherlands; Platelet Aggregation Inhibitors; Primary Prevention; Prospective Studies; Research Design; Simvastatin; Tablets; Time Factors; Treatment Outcome | 2014 |
RApid Primary care Initiation of Drug treatment for Transient Ischaemic Attack (RAPID-TIA): study protocol for a pilot randomised controlled trial.
Topics: Antihypertensive Agents; Aspirin; Cardiovascular Agents; Clinical Protocols; Dipyridamole; Drug Administration Schedule; Drug Therapy, Combination; Emergency Service, Hospital; England; Feasibility Studies; General Practice; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Attack, Transient; Pilot Projects; Primary Health Care; Referral and Consultation; Research Design; Secondary Prevention; Simvastatin; Time Factors; Treatment Outcome | 2013 |
Effects of a fixed-dose combination strategy on adherence and risk factors in patients with or at high risk of CVD: the UMPIRE randomized clinical trial.
Topics: Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atenolol; Blood Pressure; Cardiovascular Diseases; Cholesterol, LDL; Drug Combinations; Female; Humans; Hydrochlorothiazide; Lisinopril; Male; Medication Adherence; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Simvastatin; Treatment Outcome | 2013 |
A pragmatic randomized trial of a polypill-based strategy to improve use of indicated preventive treatments in people at high cardiovascular disease risk.
Topics: Administration, Oral; Adrenergic beta-1 Receptor Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aspirin; Atenolol; Australia; Biomarkers; Blood Pressure; Cardiovascular Diseases; Cholesterol; Drug Combinations; Drugs, Generic; Female; General Practice; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypertension; Lisinopril; Male; Middle Aged; Platelet Aggregation Inhibitors; Polypharmacy; Primary Prevention; Prospective Studies; Risk Factors; Simvastatin; Sodium Chloride Symporter Inhibitors; Tablets; Time Factors; Treatment Outcome | 2015 |
Effects of simvastatin/ezetimibe on microparticles, endothelial progenitor cells and platelet aggregation in subjects with coronary heart disease under antiplatelet therapy.
Topics: Aged; Anticholesteremic Agents; Aspirin; Azetidines; Cell-Derived Microparticles; Cholesterol, LDL; Clopidogrel; Coronary Disease; Drug Combinations; Endothelial Progenitor Cells; Ezetimibe; Female; Flow Cytometry; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Simvastatin; Ticlopidine; Triglycerides | 2014 |
Effects of aspirin & simvastatin and aspirin, simvastatin, & lipoic acid on heme oxygenase-1 in healthy human subjects.
Topics: Adult; Aspirin; Double-Blind Method; Female; Heme Oxygenase-1; Humans; Male; Middle Aged; Simvastatin; Thioctic Acid; Young Adult | 2014 |
Interleukin-6 and tumor necrosis factor-α are associated with quality of life-related symptoms in pulmonary arterial hypertension.
Topics: Administration, Oral; Aspirin; Biomarkers; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Pulmonary; Interleukin-6; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Pulmonary Wedge Pressure; Quality of Life; Simvastatin; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
No Effect of Omega-3 Carboxylic Acids on Pharmacokinetics/Pharmacodynamics of Warfarin or on Platelet Function When Co-administered with Acetylsalicylic Acid: Results of Two Phase I Studies in Healthy Volunteers.
Topics: Adult; Anticoagulants; Aspirin; Blood Platelets; Carboxylic Acids; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Middle Aged; Platelet Function Tests; Simvastatin; Warfarin; Young Adult | 2017 |
Impact of switching from different treatment regimens to a fixed-dose combination pill (polypill) in patients with cardiovascular disease or similarly high risk.
Topics: Administration, Oral; Aged; Antihypertensive Agents; Aspirin; Atenolol; Biomarkers; Blood Pressure; Cardiovascular Diseases; Cholesterol, LDL; Drug Combinations; Drug Substitution; Europe; Female; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; India; Lisinopril; Male; Medication Adherence; Middle Aged; Platelet Aggregation Inhibitors; Polypharmacy; Risk Assessment; Risk Factors; Simvastatin; Tablets; Time Factors; Treatment Outcome | 2017 |
Polypill with or without Aspirin in Persons without Cardiovascular Disease.
Topics: Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atenolol; Blood Pressure; Cardiovascular Diseases; Cholesterol, LDL; Drug Combinations; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Incidence; Male; Medication Adherence; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Simvastatin | 2021 |
70 other study(ies) available for aspirin and simvastatin
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.
Topics: Carboxylesterase; Carboxylic Ester Hydrolases; Enzyme Inhibitors; Humans; Ketones; Quantitative Structure-Activity Relationship | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
Topics: Drug Discovery; Pharmaceutical Preparations; Solubility; Thermodynamics | 2015 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Increased thromboxane biosynthesis in type IIa hypercholesterolemia.
Topics: Adult; Aged; Anticholesteremic Agents; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Thromboxane A2 | 1992 |
Non-invasive management of coronary artery disease. Report of a meeting at the University of Texas Medical School at Houston.
Topics: Aged; Anticholesteremic Agents; Aspirin; beta Carotene; Carotenoids; Cholesterol, Dietary; Coronary Disease; Diet, Fat-Restricted; Diltiazem; Drug Therapy, Combination; Enalapril; Humans; Lovastatin; Male; Simvastatin; Tomography, Emission-Computed; Vitamins | 1995 |
Use of statins. Other, cheaper and simpler, measures should be tried first.
Topics: Adrenergic beta-Agonists; Aspirin; Coronary Disease; Humans; Hypolipidemic Agents; Risk Assessment; Simvastatin | 1997 |
Secondary prevention in coronary heart disease. Cost effectiveness of treatment must be borne in mind.
Topics: Aspirin; Coronary Disease; Cost-Benefit Analysis; Humans; Hypolipidemic Agents; Simvastatin | 1998 |
Meeting highlights. Highlights of the 48th scientific sessions of the American College of Cardiology.
Topics: Abciximab; Alanine; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitors; Antibodies, Monoclonal; Aspirin; Benzamidines; Biphenyl Compounds; Cardiology; Cardiovascular Agents; Clinical Trials as Topic; Clopidogrel; Combined Modality Therapy; Coronary Disease; Dalteparin; Defibrillators, Implantable; Double-Blind Method; Enalapril; Endothelial Growth Factors; Fatty Acids, Omega-3; Guanidines; Heart Failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoglobulin Fab Fragments; Laser Therapy; Lymphokines; Metoprolol; Multicenter Studies as Topic; Myocardial Revascularization; Platelet Aggregation Inhibitors; Pyrrolidines; Randomized Controlled Trials as Topic; Simvastatin; Sodium-Hydrogen Exchangers; Stents; Sulfones; Thrombolytic Therapy; Ticlopidine; Tissue Plasminogen Activator; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vitamin E | 1999 |
Ten year audit of secondary prevention in coronary bypass patients.
Topics: Anticholesteremic Agents; Aspirin; Blood Pressure; Cholesterol; Coronary Artery Bypass; Humans; Medical Audit; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Factors; Simvastatin | 2000 |
Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; C-Reactive Protein; Humans; Hypercholesterolemia; Inflammation; Interleukin-6; Interleukin-8; Male; Middle Aged; Simvastatin; Tumor Necrosis Factor-alpha | 2001 |
American Heart Association 2001 scientific sessions: late-breaking science-statins: the new aspirin?
Topics: Adult; Aged; Anticholesteremic Agents; Antioxidants; Aspirin; Cardiovascular Diseases; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Simvastatin; Vitamins | 2001 |
Niacin and the National Cholesterol Education Program Adult Treatment Panel III Guidelines: case studies.
Topics: Aspirin; Atenolol; Blood Chemical Analysis; Coronary Disease; Female; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Niacin; Obesity; Risk Factors; Simvastatin | 2003 |
[Primary prevention of stroke. What helps--what does not help? The guidelines of the German Society of Neurology briefly summarized].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Alcohol Drinking; Anticholesteremic Agents; Anticoagulants; Antihypertensive Agents; Arrhythmias, Cardiac; Aspirin; Atenolol; Atrial Fibrillation; Carotid Artery, Internal; Carotid Stenosis; Chlorthalidone; Clinical Trials as Topic; Diabetes Complications; Diuretics; Doxazosin; Female; Fibrinolytic Agents; Hormone Replacement Therapy; Humans; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Life Style; Losartan; Male; Neurology; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Pravastatin; Primary Prevention; Risk Factors; Simvastatin; Smoking; Societies, Medical; Stroke | 2003 |
C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases.
Topics: Acute-Phase Reaction; Aspirin; Atorvastatin; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Clinical Trials as Topic; Coronary Artery Disease; Heptanoic Acids; Humans; Incidence; Inflammation; Interleukin-6; Lovastatin; Pravastatin; Predictive Value of Tests; Pyrroles; Risk Factors; Simvastatin | 2004 |
[Inhibition of adenosine deaminase activity by drugs influencing the cardiovascular system].
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Aspirin; Cardiovascular Agents; Cardiovascular System; Deoxyadenosines; Female; Fibrinolytic Agents; Isoenzymes; Isosorbide Dinitrate; Male; Metoprolol; Molsidomine; Rabbits; Random Allocation; Simvastatin; Vasodilator Agents; Vasomotor System | 2004 |
Statins and aspirin in chronic kidney disease: what does the UK-HARP-I trial tell us?
Topics: Aspirin; Cardiovascular Diseases; Cholesterol; Chronic Disease; Disease Progression; Hemorrhage; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Diseases; Kidney Transplantation; Peritoneal Dialysis; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Renal Dialysis; Research Design; Simvastatin; Treatment Outcome | 2005 |
A case of acute pancreatitis possibly associated with combined salicylate and simvastatin treatment.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Cholangiopancreatography, Magnetic Resonance; Coronary Disease; Drug Therapy, Combination; Humans; Hypercholesterolemia; Male; Middle Aged; Pancreatitis; Simvastatin; Tomography, X-Ray Computed | 2005 |
Acute myocardial infarction in a patient with severe unrecognized mitral stenosis.
Topics: Analgesics; Anti-Arrhythmia Agents; Anticholesteremic Agents; Anticoagulants; Aspirin; Atrial Fibrillation; Diuretics; Echocardiography, Transesophageal; Electrocardiography; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Hydrochlorothiazide; Metoprolol; Middle Aged; Mitral Valve Stenosis; Myocardial Infarction; Nadroparin; Simvastatin; Time Factors; Treatment Outcome | 2006 |
[Guidelines given by the DSG and DGN concerning stroke therapy--new therapeutic aspects].
Topics: Aged; Antihypertensive Agents; Aspirin; Carotid Stenosis; Cerebral Infarction; Combined Modality Therapy; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Secondary Prevention; Simvastatin | 2006 |
Myocardial infarcts in a patient with a single right sided coronary ostium and interarterial course of the circumflex artery: the role of multi-modality imaging.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Bisoprolol; Coronary Angiography; Coronary Vessel Anomalies; Coronary Vessels; Female; Humans; Magnetic Resonance Angiography; Middle Aged; Myocardial Infarction; Perindopril; Platelet Aggregation Inhibitors; Simvastatin; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed | 2009 |
LC and LC-MS methods for the investigation of polypills for the treatment of cardiovascular diseases. Part 1. Separation of active components and classification of their interaction/degradation products.
Topics: Aspirin; Atenolol; Atorvastatin; Cardiovascular Agents; Chromatography, High Pressure Liquid; Drug Combinations; Drug Interactions; Drug Stability; Heptanoic Acids; Hydrochlorothiazide; Lisinopril; Pravastatin; Pyrroles; Simvastatin; Spectrometry, Mass, Electrospray Ionization | 2008 |
Rhabdomyolysis resulting from pharmacologic interaction between erlotinib and simvastatin.
Topics: Aged; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atenolol; Azetidines; Carcinoma, Non-Small-Cell Lung; Coronary Artery Disease; Drug Interactions; Erlotinib Hydrochloride; Ezetimibe; Female; Humans; Hyperlipidemias; Hypertension; Lung Neoplasms; Neoplasm Recurrence, Local; Protein Kinase Inhibitors; Quinazolines; Rhabdomyolysis; Simvastatin; Tomography, X-Ray Computed | 2008 |
Effects of simvastatin, acetylsalicylic acid, and rosiglitazone on proliferation of normal and cancerous prostate epithelial cells at therapeutic concentrations.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Division; Cell Line, Transformed; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Epithelial Cells; Growth Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Prostate; Prostatic Neoplasms; Rosiglitazone; Simvastatin; Thiazolidinediones | 2009 |
Prothrombinase formation at the site of microvascular injury and aspirin resistance: the effect of simvastatin.
Topics: Arachidonic Acid; Aspirin; Bleeding Time; Drug Combinations; Drug Resistance; Factor X; Fasting; Humans; Male; Middle Aged; Outpatients; Platelet Aggregation; Simvastatin; Thromboplastin; Time Factors; Wounds and Injuries | 2010 |
Approach to the patient who is intolerant of statin therapy.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Atorvastatin; Coronary Disease; Diltiazem; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Middle Aged; Pyrroles; Simvastatin | 2010 |
The inhibitory effect of statins on urinary 11-dehydrothromboxane levels.
Topics: Aged; Aspirin; Atorvastatin; Biomarkers; Blood Glucose; Blood Platelets; C-Reactive Protein; Cholesterol, HDL; Cholesterol, LDL; Czech Republic; Down-Regulation; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; Platelet Aggregation Inhibitors; Pyrroles; Simvastatin; Thromboxane B2; Time Factors; Treatment Outcome; Triglycerides | 2010 |
How can stretching maneuvers involving the neck cause vertebral artery dissection and transient ischemic attack?
Topics: Adult; Aged; Aspirin; Confusion; Headache; Heparin; Humans; Ischemic Attack, Transient; Muscle Stretching Exercises; Neck; Simvastatin; Treatment Outcome; Vertebral Artery Dissection; Warfarin | 2010 |
Dipyridamole with low-dose aspirin augments the infarct size-limiting effects of simvastatin.
Topics: Animals; Aspirin; CREB-Binding Protein; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Simvastatin | 2010 |
Acute mutism: a useful lesson.
Topics: Acute Disease; Adult; Aphasia, Broca; Aspirin; Cerebral Infarction; Diagnosis, Differential; Drug Therapy, Combination; Emergency Service, Hospital; Follow-Up Studies; Frontal Lobe; Humans; Magnetic Resonance Angiography; Male; Mutism; Simvastatin; Tomography, X-Ray Computed; Treatment Outcome | 2011 |
Clinical implications of the cytokine hypothesis of depression: the association between use of statins and aspirin and the risk of major depression.
Topics: Aspirin; Atorvastatin; Case-Control Studies; Confidence Intervals; Cytokines; Depressive Disorder, Major; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kaplan-Meier Estimate; Middle Aged; Models, Psychological; Pravastatin; Pyrroles; Retrospective Studies; Risk Factors; Simvastatin; Time Factors | 2010 |
Simvastatin administration reduces thromboxane production in subjects taking aspirin: links between aspirin resistance and thrombin generation.
Topics: Aspirin; Cardiovascular Diseases; Drug Resistance; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation Inhibitors; Simvastatin; Thrombin; Thromboxane A2 | 2012 |
A population pharmacokinetic-pharmacodynamic model for simvastatin that predicts low-density lipoprotein-cholesterol reduction in patients with primary hyperlipidaemia.
Topics: Adult; Aspirin; Cholesterol, LDL; Computer Simulation; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Male; Middle Aged; Models, Biological; Predictive Value of Tests; Simvastatin; Young Adult | 2011 |
Dissection of the posterior inferior cerebellar artery in the hypereosinophilic syndrome.
Topics: Adolescent; Anti-Inflammatory Agents; Aortic Dissection; Arteries; Aspirin; Cerebellum; Female; Humans; Hypereosinophilic Syndrome; Interferon-alpha; Intracranial Aneurysm; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Platelet Aggregation Inhibitors; Prednisone; Simvastatin; Stroke | 2011 |
Future of clinical trials for pulmonary hypertension.
Topics: Aspirin; Drug Therapy, Combination; Exercise Tolerance; Humans; Hypertension, Pulmonary; Randomized Controlled Trials as Topic; Simvastatin; Treatment Outcome; Walking | 2011 |
Avascular necrosis of the knees and ulcerative colitis.
Topics: Adrenal Cortex Hormones; Adult; Aspirin; Cholecalciferol; Colitis, Ulcerative; Cyclosporine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Knee Joint; Male; Mesalamine; Osteonecrosis; Pain; Platelet Aggregation Inhibitors; Radiography; Simvastatin; Vitamins | 2011 |
Pravastatin and simvastatin improves acetylsalicylic acid-mediated in vitro blood platelet inhibition.
Topics: Adult; Aspirin; Atorvastatin; Blood Platelets; Cholesterol; Drug Interactions; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Pravastatin; Pyrroles; Simvastatin; Young Adult | 2012 |
Reverse Takotsubo pattern stress cardiomyopathy in a male patient induced during dobutamine stress echocardiography.
Topics: Aspirin; Bisoprolol; Cardiomyopathies; Cardiotonic Agents; Chest Pain; Dobutamine; Echocardiography, Stress; Enalapril; Humans; Male; Middle Aged; Simvastatin | 2012 |
Intestinal ischaemia and mesenteric necrosis in a heavy smoker.
Topics: Abdominal Pain; Aspirin; Diarrhea; Humans; Jejunal Diseases; Male; Mesenteric Arteries; Middle Aged; Necrosis; Simvastatin; Smoking Cessation; Thromboangiitis Obliterans; Treatment Outcome; Weight Loss | 2013 |
A 'polypill' aimed at preventing cardiovascular disease could prove highly cost-effective for use in Latin America.
Topics: Aged; Antihypertensive Agents; Aspirin; Atenolol; Cardiovascular Diseases; Cohort Studies; Cost-Benefit Analysis; Developing Countries; Drug Combinations; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Latin America; Male; Markov Chains; Middle Aged; Quality-Adjusted Life Years; Ramipril; Randomized Controlled Trials as Topic; Risk Factors; Simvastatin; Sodium Chloride Symporter Inhibitors | 2013 |
Doctor, my dentist wants your opinion.
Topics: Angioplasty; Antibiotic Prophylaxis; Aspirin; Dental Care for Chronically Ill; Dentists; Drug Interactions; Endocarditis; Humans; Hyperlipidemias; Macrolides; Male; Mitral Valve Prolapse; Myocardial Ischemia; Platelet Aggregation Inhibitors; Simvastatin; Streptococcal Infections; Tooth Extraction; Viridans Streptococci | 2013 |
Reduction of platelet cytosolic phospholipase A2 activity by atorvastatin and simvastatin: biochemical regulatory mechanisms.
Topics: Anticholesteremic Agents; Aspirin; Atorvastatin; Blood Platelets; Calcium; Collagen; Cyclooxygenase 1; Drug Combinations; Drug Synergism; Heptanoic Acids; Humans; Mitogen-Activated Protein Kinases; Phospholipase A2 Inhibitors; Phospholipases A2; Phosphorylation; Platelet Aggregation; Pravastatin; Pyrroles; Simvastatin; Thromboxane A2; Thromboxane-A Synthase | 2013 |
Predicting the impact of polypill use in a metabolic syndrome population: an effectiveness and cost-effectiveness analysis.
Topics: Adult; Aged; Antihypertensive Agents; Aspirin; Cardiovascular Diseases; Cost-Benefit Analysis; Drug Combinations; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Metabolic Syndrome; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Simvastatin; Treatment Outcome | 2013 |
Effect of simvastatin on inflammatory cytokines balance in air pouch granuloma model.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; C-Reactive Protein; Cells, Cultured; Cytokines; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Granuloma; Inflammation Mediators; Male; Malondialdehyde; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Simvastatin | 2014 |
The inhibitory effect of simvastatin and aspirin on histamine responsiveness in human vascular endothelial cells.
Topics: Actin Cytoskeleton; Actins; Antigens, CD; Aspirin; Cadherins; Calcium; Calcium Signaling; Cardiovascular Agents; Cell Shape; Cells, Cultured; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Histamine; Histamine Agonists; Histamine Antagonists; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Phosphorylation; Receptors, Histamine H1; Simvastatin; Time Factors | 2014 |
Tips for GP trainees working in vascular surgery.
Topics: Anticholesteremic Agents; Aspirin; Blood Pressure; Clinical Competence; Clopidogrel; Education, Medical, Graduate; General Practice; Humans; Learning; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Simvastatin; Smoking Cessation; Ticlopidine; Vascular Diseases; Vascular Surgical Procedures | 2014 |
Simultaneous quantitation of aspirin, amlodipine and simvastatin in a fixed dose combination of encapsulated tablet formulation by HPLC-UV method.
Topics: Amlodipine; Aspirin; Cardiovascular Agents; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drug Combinations; Limit of Detection; Reproducibility of Results; Simvastatin; Spectrophotometry, Ultraviolet; Tablets; Technology, Pharmaceutical | 2014 |
[Special characteristics of progression of myocardial remodeling in patients with various forms of unstable angina].
Topics: Aged; Angina, Unstable; Aspirin; Benzopyrans; Cardiovascular Agents; Disease Progression; Drug Therapy, Combination; Echocardiography, Doppler; Ethanolamines; Female; Heart Failure; Humans; Male; Middle Aged; Nebivolol; Outcome Assessment, Health Care; Perindopril; Platelet Aggregation Inhibitors; Prognosis; Severity of Illness Index; Simvastatin; Time Factors; Ventricular Remodeling | 2014 |
Stroke mimicking relapse in a patient with CLIPPERS syndrome.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Brain Stem; Encephalomyelitis; Gadolinium; Humans; Hypoglycemic Agents; Inflammation; Magnetic Resonance Imaging; Male; Metformin; Middle Aged; Recurrence; Simvastatin; Stroke | 2015 |
Regulation effect of Aspirin Eugenol Ester on blood lipids in Wistar rats with hyperlipidemia.
Topics: Animals; Aspirin; Dietary Fats; Eugenol; Hyperlipidemias; Hypolipidemic Agents; Male; Random Allocation; Rats; Simvastatin | 2015 |
Low miR-19b-1-5p expression in isolated platelets after aspirin use is related to aspirin insensitivity.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Blood Platelets; Coronary Artery Disease; Drug Resistance; Humans; Indomethacin; Male; MicroRNAs; Middle Aged; Platelet Aggregation Inhibitors; RNA; Simvastatin | 2016 |
Cost-benefit analysis of the polypill in the primary prevention of myocardial infarction and stroke.
Topics: Aged; Aged, 80 and over; Amlodipine; Aspirin; Cardiovascular Agents; Case-Control Studies; Cohort Studies; Cost-Benefit Analysis; Humans; Hydrochlorothiazide; Losartan; Markov Chains; Middle Aged; Myocardial Infarction; Polypharmacy; Primary Prevention; Quality-Adjusted Life Years; Simvastatin; Stroke; United Kingdom | 2016 |
Hansen solubility parameters for assay method optimization of simvastatin, ramipril, atenolol, hydrochlorothiazide and aspirin in human plasma using liquid chromatography with tandem mass spectrometry.
Topics: Aspirin; Atenolol; Chromatography, Liquid; Humans; Hydrochlorothiazide; Ramipril; Reproducibility of Results; Simvastatin; Solubility; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2017 |
Concurrent new drug prescriptions and prognosis of early breast cancer: studies using the Danish Breast Cancer Group clinical database.
Topics: Adrenergic beta-Antagonists; Analgesics, Opioid; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Cardiotonic Agents; Cyclooxygenase 2 Inhibitors; Databases, Factual; Denmark; Digoxin; Disease Progression; Estrogen Antagonists; Female; Glucocorticoids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neoplasm Recurrence, Local; Platelet Aggregation Inhibitors; Prognosis; Selective Serotonin Reuptake Inhibitors; Simvastatin; Tamoxifen | 2018 |
[The experimental study of simvastatin on improving aspirin resistance in diabetic rats].
Topics: Animals; Aspirin; Diabetes Mellitus, Experimental; Endothelium, Vascular; Epoprostenol; Male; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Simvastatin; Thromboxane B2 | 2016 |
Fixed Dose Combination Formulations: Multilayered Platforms Designed for the Management of Cardiovascular Disease.
Topics: Aspirin; Cardiovascular Diseases; Dosage Forms; Drug Combinations; Drug Compounding; Drug Delivery Systems; Drug Design; Drug Liberation; Hot Melt Extrusion Technology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Polyethylene Glycols; Polyvinyls; Pyrrolidines; Simvastatin; Solubility; Vinyl Compounds | 2019 |
Notch receptor expression in Trypanosoma cruzi-infected human umbilical vein endothelial cells treated with benznidazole or simvastatin revealed by microarray analysis.
Topics: Aspirin; Cells, Cultured; Chagas Disease; Gene Expression; HMGB1 Protein; Human Umbilical Vein Endothelial Cells; Humans; Nitroimidazoles; Receptor, Notch1; Simvastatin; Trypanosoma cruzi | 2020 |
Effect of Simvastatin Use in Free Tissue Transfer: An Experimental Study in a Rat Epigastric Free Flap Model.
Topics: Animals; Aspirin; Epigastric Arteries; Free Tissue Flaps; Graft Survival; Models, Animal; Rats; Rats, Sprague-Dawley; Simvastatin | 2020 |
Analysis of quinary therapy targeting multiple cardiovascular diseases using UV spectrophotometry and chemometric tools.
Topics: Algorithms; Aspirin; Atenolol; Capsules; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Humans; Hydrochlorothiazide; Least-Squares Analysis; Ramipril; Simvastatin; Spectrophotometry, Ultraviolet | 2020 |
Preparation and characterization of polypills containing aspirin and simvastatin using 3D printing technology for the prevention of cardiovascular diseases.
Topics: Aspirin; Cardiovascular Diseases; Humans; Printing, Three-Dimensional; Simvastatin; Technology, Pharmaceutical | 2020 |
Cardiovascular disease preventive effects of aspirin combined with different statins in the United States general population.
Topics: Aspirin; Cardiovascular Diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Rosuvastatin Calcium; Simvastatin; United States | 2023 |