aspirin and rofecoxib

aspirin has been researched along with rofecoxib in 111 studies

Research

Studies (111)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (1.80)	18.2507
2000's	97 (87.39)	29.6817
2010's	11 (9.91)	24.3611
2020's	1 (0.90)	2.80

Authors

Authors	Studies
Bohlin, L; Huss, U; Perera, P; Ringbom, T; Vasänge, M	1
Knaus, EE; McDonald, R; Praveen Rao, PN; Uddin, MJ	1
Backlund, A; Bohlin, L; Gottfries, J; Larsson, J	1
Chen, QH; Knaus, EE; Rao, PN	1
Franklin, PX; Nivsarkar, M; Padh, H; Pillai, AD; Rathod, PD; Sudarsanam, V; Vasu, KK; Yerande, S	1
Abdellatif, KR; Chen, QH; Chowdhury, MA; Dong, Y; Knaus, EE	3
Andricopulo, AD; Moda, TL; Montanari, CA	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chang, PT; Chen, CS; Chen, GS; Chern, JW; Tan, CM	1
Bhardwaj, A; Huang, Z; Kaur, J; Knaus, EE; Sharma, SK; Wuest, F	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Achenbach, J; Barzen, S; Brüggerhoff, A; Hofmann, B; Ihlefeld, K; Kretschmer, SB; Proschak, E; Rödl, CB; Stark, H; Steinhilber, D; Vogt, D	1
Hawkey, CJ	1
Bolognese, JA; Harper, SE; Hoover, ME; Lanza, FL; Quan, H; Rack, MF; Simon, TJ; Wilson, FR	1
Dorval, E; Gillen, L; Gottesdiener, K; Greenberg, HE; Huntington, M; Larson, P; Waldman, SA; Wildonger, L; Wong, P	1
Bjarnason, I; Rainsford, KD	1
Bochenek, G; Mejza, F; Nagraba, K; Nizankowska, E; Swierczynska, M; Szczeklik, A	1
Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Ptak, A; Sliwowski, Z	1
Bijlsma, JW; Lems, WF; van de Laar, MA	1
García Rodríguez, LA; Patrignani, P; Patrono, C	1
Simon, RA; Stevenson, DD	1
Hinrichs, R; Hunzelmann, N; Krieg, T; Ritzkowsky, A; Scharffetter-Kochanek, K	1
Nakamura, H	1
Cleland, LG; James, MJ; Penglis, PS; Stamp, LK	1
Ouellet, M; Percival, MD; Riendeau, D	1
Catella-Lawson, F; Cucchiara, AJ; DeMarco, S; FitzGerald, GA; Kapoor, SC; Reilly, MP; Tournier, B; Vyas, SN	1
Bottner, F; Grethen, C; Lindner, N; Roedl, R; Winkelmann, W; Wortler, K	1
Hawkey, CJ; Jones, JI	1
Barbagallo, M; Biasi, D; Corrocher, R; Di Lorenzo, G; Pacor, ML	1
Sharma, RA	1
Crofford, LJ	1
Barkun, AN; Baron, D; Bombardier, C; Bursey, FR; Hunt, RH; Marshall, JR; Morgan, DG; Paré, P; Thomson, AB; Whittaker, JS	1
Clifford, LJ; Dewitt, DL; Nair, MG; Rana, J	1
Alfaya, T; Berges, P; Camacho, E; García-Rodriguez, R; Hinojosa, M; Iscar, A; Martín-García, C	1
Stover, RR	1
Brozek, J; Gajewski, P; Jaeschke, R	1
Knaus, EE; Rahim, MA; Rao, PN	1
de Lima, OM; Dicay, M; Distrutti, E; Fiorucci, S; Ma, L; McKnight, W; Mencarelli, A; Morelli, A; Palazzetti, B; Romano, M; Wallace, JL	1
Clausen, C; Gires, O; Hölzel, D; Kastenbauer, E; Lang, S; Lauffer, L; Löhr, I; Schmitt, B; Wollenberg, B; Zeidler, R	1
de Lima, OM; Fiorucci, S; Souza, MH; Wallace, JL; Zamuner, SR	1
Inoue, K; Kawahito, Y; Sano, H; Takano, H; Yoshikawa, T	1
Gyr, N; Lehmann, FS	1
Cmiel, A; Mejza, F; Szczeklik, A; Tuleja, E	1
Charachon, A; Lamarque, D; Petit, T; Soulé, JC	1
Feige, U; Giulietti, A; Gysemans, C; Lannoo, M; Mathieu, C; Overbergh, L; Stoffels, K; Waer, M	1
Hawkey, CJ; James, MW	1
Burnier, M; Chiolero, A; Maillard, MP	1
Fernández, C; West, PM	1
Dixon, ME; Geba, GP; Johansson, G; Lisse, JR; Mollen, AJ; Perlman, M; Polis, AB; Schechtman, J; Shoemaker, JR; Skalky, CS	1
Gertz, BJ; Reicin, A; Sperling, RS; Weir, MR	1
Giddens, K; McInerney, MM; McQueen, MJ; Nassar, BA; Title, LM	1
Mastalerz, L; Radziszewski, W; Setkowicz, M; Szczeklik, A; Zembowicz, A	1
Gürton, AU; Olmez, H; Sari, E	1
Al-Falaki, O; Blaicher, AM; Gruber, D; Hoerauf, K; Landsteiner, HT; Volf, I; Zimpfer, M; Zwerina, J	1
Bavbek, S; Celik, G; Misirligil, Z; Mungan, D; Ozer, F	1
Arderiu, G; Escolar, G; Hernandez, MR; Pino, M; Serradell, M; Tonda, R	1
Ashley, SW; Benoit, E; Duxbury, M; Farivar, RS; Gardner-Thorpe, J; Ito, H; Whang, EE; Zinner, MJ	1
Brunner, M; Gehrmann, M; Kremmer, E; Multhoff, G; Pfister, K; Reichle, A	1
García Rodríguez, LA; González-Pérez, A; Maguire, A; Varas-Lorenzo, C	1
Laine, L; Maller, ES; Quan, H; Simon, T; Yu, C	1
Bertrand, F; Bogaty, P; Boyer, L; Brophy, JM; Dagenais, GR; Noel, M; Simard, S	1
Antonicelli, L; Bilò, MB; Bonadonna, P; Crivellaro, MA; Dama, AR; Schiappoli, M; Senna, G	1
Bannwarth, B; Logeart, I; Vergult, G	1
Bejarano, M; Cohen, J; Ferrante, RJ; Fox, J; Gutekunst, CA; Hersch, SM; Nanje, A; Norflus, F; Shi, G	1
Bardou, M; Barkun, AN; Ghosn, J; Hudson, M; Rahme, E	1
Blaicher, AM; Hoerauf, K; Landsteiner, HT; Leitgeb, U; Volf, I; Zwerina, J	1
Bégaud, B; Boisseau, M; Moore, N; Umar, A; Upur, H; Yusup, A	1
Simon, RA; Stevenson, DD; Woessner, KM	1
Mendoza, JL; Taxonera, C	1
Amengual Antich, I; Morón Canis, JM; Noguera Aguilar, JF; Plaza Martínez, A; Pujol Tugores, JJ; Tortajada Collado, C	1
Wolfe, MM	1
Bello, AE; Fort, JG; Goldstein, JL; Spalding, W; Suh, S	1
Berlin, JA; Chittams, J; Jaskowiak, J; Kimmel, SE; Kishel, L; Reilly, M; Strom, BL	1
Baron, JA; Bolognese, JA; Bresalier, RS; Horgan, K; Konstam, MA; Lanas, A; Lines, C; Morton, D; Oxenius, B; Quan, H; Riddell, R; Sandler, RS	1
Arellano, FM	1
Marshall, LL	1
Chiou, CF; Ofman, JJ; Spiegel, BM	1
de Champlain, J; Laplante, MA; Wu, R	2
Asero, R	2
Carl-McGrath, S; Chen, J; Ebert, MP; Gu, P; Hoffmann, J; Kubisch, C; Malfertheiner, P; Röcken, C; Schäfer, C; Treiber, G	1
Amengual Antich, I; Gamundí Gamundí, A; Ibarra de la Rosa, J; Noguera Aguilar, JF; Plaza Martínez, A; Pujol Tugores, JJ; Tortajada Collado, C	1
de Leon-Casasola, OA; Kotob, F; Lema, MJ	1
Bishop-Bailey, D; Mitchell, JA; Vojnovic, I; Warner, TD	1
Bucciarelli, T; Ciabattoni, G; Davì, G; Del Re, L; Di Febbo, C; Di Iorio, A; Falco, A; Giusti, C; Paganelli, R; Patrono, C; Pescara, L; Porreca, E; Sau, A	1
Dal Negro, R; Guerriero, M; Micheletto, C; Tognella, S	1
Kaur, B; Levine, D; Sood, S; Traxler, B; Triadafilopoulos, G; Weston, A	1
Bavbek, S; Celik, G; Misirligil, Z; Pasaoglu, G	1
Armstrong, PW	1
Cerletti, C; Dell'Elba, G; Evangelista, V; Manarini, S; Rotondo, S	1
Teixeira, MZ	2
Stix, G	1
Nedjar, H; Rahme, E	1
Alshafie, GA; Beebe-Donk, J; Harris, RE	1
Heim, HK; Hohlfeld, T; Schrör, K; Schumacher, M; Weber, AA	1
Hallenbeck, JM; Michaud, K; Nadareishvili, Z; Wolfe, F	1
Harrington, LS; Lucas, R; McMaster, SK; Mitchell, JA; Moreno, L; Scadding, G; Warner, TD	1
Chopra, K; Dhir, A; Kuhad, A; Nandal, S; Sharma, S	1
Baumgärtel-Allekotte, D; Fischer, J; Heim, Kh; Kaber, G; Kaiser, B; Nagy, N; Nossmann, S; Rauch, B; Schrör, K; Weber, A	1
Gołab, J; Jakubowska-Mućka, A; Lasek, W; Sieńko, J; Switaj, T	1
Church, DN; Davidson, B; Domingo, E; Johnstone, E; Kerr, DJ; Midgley, R; Ramamoorthy, R; Sieber, O; Tomlinson, IP; Yanagisawa, Y	1
Fuchs, CS; Ogino, S	1
Anderson, B; Cooper, TE; Eccleston, C; Fisher, E; Wilkinson, NM	1
Devane, D; Jordan, F; Kelly, JP; McGuinness, B; Murphy, K; Passmore, P; Quinn, TJ; Tudur Smith, C	1

Reviews

20 review(s) available for aspirin and rofecoxib

Article	Year
COX-2 inhibitors and the gastrointestinal tract. Gut, 2001, Volume: 48, Issue:4 Topics: Animals; Aspirin; Celecoxib; Cyclooxygenase 2; Drug Interactions; Humans; Intestinal Mucosa; Isoenzymes; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rodentia; Sulfonamides; Sulfones	2001
[Safety of specific cyclo-oxygenase 2 inhibitors]. Nederlands tijdschrift voor geneeskunde, 2001, Jun-02, Volume: 145, Issue:22 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Humans; Incidence; Lactones; Netherlands; Peptic Ulcer; Prospective Studies; Pyrazoles; Sulfonamides; Sulfones	2001
Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs. The Journal of clinical investigation, 2001, Volume: 108, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Blood Platelets; Cardiovascular Diseases; Celecoxib; Colorectal Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Depression, Chemical; Dinoprostone; Epoprostenol; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Incidence; Intestinal Mucosa; Isoenzymes; Lactones; Membrane Proteins; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Randomized Controlled Trials as Topic; Substrate Specificity; Sulfonamides; Sulfones; Thromboembolism; Thromboxane A2; Treatment Outcome	2001
[Cyclooxygenase (COX)-2 selective inhibitors: aspirin, a dual COX-1/COX-2 inhibitor, to COX-2 selective inhibitors]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2001, Volume: 118, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Clinical Trials as Topic; Colorectal Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Fever; Hemorrhage; Humans; Isoenzymes; Kidney Diseases; Lactones; Membrane Proteins; Pain; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones	2001
COX-2 inhibition and thrombotic tendency: a need for surveillance. The Medical journal of Australia, 2001, Aug-20, Volume: 175, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Female; Gastrointestinal Diseases; Humans; Lactones; Middle Aged; Pyrazoles; Randomized Controlled Trials as Topic; Risk Factors; Sulfonamides; Sulfones; Venous Thrombosis	2001
COX-2 inhibitors: no pain, no heart gain? Harvard heart letter : from Harvard Medical School, 2001, Volume: 12, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Clinical Trials as Topic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Lactones; Membrane Proteins; Pain; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones	2001
Gastrointestinal safety of COX-2 specific inhibitors. Gastroenterology clinics of North America, 2001, Volume: 30, Issue:4 Topics: Adrenal Cortex Hormones; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Synergism; Helicobacter Infections; Humans; Isoenzymes; Lactones; Membrane Proteins; Naproxen; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Sulfones	2001
Translational medicine: targetting cyclo-oxygenase isozymes to prevent cancer. QJM : monthly journal of the Association of Physicians, 2002, Volume: 95, Issue:5 Topics: Arachidonic Acid; Aspirin; Cardiovascular Diseases; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Design; Humans; Isoenzymes; Lactones; Membrane Proteins; Neoplasms; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; Sulfones	2002
Specific cyclooxygenase-2 inhibitors: what have we learned since they came into widespread clinical use? Current opinion in rheumatology, 2002, Volume: 14, Issue:3 Topics: Arthritis; Aspirin; Cardiovascular System; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Humans; Isoenzymes; Kidney; Lactones; Membrane Proteins; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Risk Factors; Sulfonamides; Sulfones	2002
Recommendations for the appropriate use of anti-inflammatory drugs in the era of the coxibs: defining the role of gastroprotective agents. Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2002, Volume: 16, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Gastrointestinal Diseases; Humans; Incidence; Lactones; Practice Guidelines as Topic; Predictive Value of Tests; Randomized Controlled Trials as Topic; Recurrence; Risk Factors; Sulfones; Treatment Outcome	2002
[The future of peptic ulcer disease without Helicobacter]. Praxis, 2003, Mar-19, Volume: 92, Issue:12 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Aspirin; Celecoxib; Child; Double-Blind Method; Female; Helicobacter Infections; Helicobacter pylori; Humans; Incidence; Lactones; Male; Meta-Analysis as Topic; Osteoarthritis; Peptic Ulcer; Prevalence; Pyrazoles; Randomized Controlled Trials as Topic; Risk Factors; Sulfonamides; Sulfones	2003
Assessment of non-steroidal anti-inflammatory drug (NSAID) damage in the human gastrointestinal tract. British journal of clinical pharmacology, 2003, Volume: 56, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endoscopy, Gastrointestinal; Gastric Mucosa; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Humans; Isoenzymes; Lactones; Membrane Proteins; Prognosis; Prostaglandin-Endoperoxide Synthases; Radionuclide Imaging; Randomized Controlled Trials as Topic; Recurrence; Sulfones	2003
Cardiovascular hazard of selective COX-2 inhibitors: myth or reality? Expert opinion on drug safety, 2002, Volume: 1, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cardiovascular Diseases; Celecoxib; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Humans; Lactones; Osteoarthritis; Pyrazoles; Risk Factors; Sulfonamides; Sulfones	2002
Safety of COX-2 inhibitors in asthma patients with aspirin hypersensitivity. The Annals of pharmacotherapy, 2003, Volume: 37, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Celecoxib; Cyclooxygenase 2; Drug Hypersensitivity; Humans; Isoenzymes; Lactones; Membrane Proteins; Meta-Analysis as Topic; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones	2003
Selective COX-2 inhibition and cardiovascular effects: a review of the rofecoxib development program. American heart journal, 2003, Volume: 146, Issue:4 Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Blood Pressure; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Interactions; Drug Therapy, Combination; Endothelium, Vascular; Epoprostenol; Humans; Isoenzymes; Lactones; Membrane Proteins; Models, Animal; Naproxen; Osteoarthritis; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Randomized Controlled Trials as Topic; Sulfones; Thrombosis; Thromboxanes	2003
Angioedema associated with aspirin and rofecoxib. The Annals of pharmacotherapy, 2005, Volume: 39, Issue:5 Topics: Adult; Aged; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Female; Humans; Lactones; Male; Middle Aged; Sulfones	2005
Minimizing complications from nonsteroidal antiinflammatory drugs: cost-effectiveness of competing strategies in varying risk groups. Arthritis and rheumatism, 2005, Apr-15, Volume: 53, Issue:2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Celecoxib; Cost-Benefit Analysis; Drug Therapy, Combination; Gastrointestinal Diseases; Humans; Lactones; Lansoprazole; Naproxen; Omeprazole; Proton Pump Inhibitors; Pyrazoles; Rheumatology; Sulfonamides; Sulfones	2005
Evidence of the principle of similitude in modern fatal iatrogenic events. Homeopathy : the journal of the Faculty of Homeopathy, 2006, Volume: 95, Issue:4 Topics: Antidepressive Agents; Aspirin; Bronchodilator Agents; Dose-Response Relationship, Drug; Drug Prescriptions; Evidence-Based Medicine; Homeopathy; Humans; Iatrogenic Disease; Lactones; Materia Medica; Research Design; Sulfones; Treatment Outcome	2006
Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. The Cochrane database of systematic reviews, 2017, 08-02, Volume: 8 Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Arthritis, Rheumatoid; Aspirin; Celecoxib; Child; Child, Preschool; Chronic Disease; Chronic Pain; Fenoprofen; Humans; Ibuprofen; Lactones; Meloxicam; Methoxsalen; Naproxen; Randomized Controlled Trials as Topic; Sulfones; Thiazines; Thiazoles	2017
Aspirin and other non-steroidal anti-inflammatory drugs for the prevention of dementia. The Cochrane database of systematic reviews, 2020, 04-30, Volume: 4 Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Dementia; Hemorrhage; Humans; Incidence; Lactones; Middle Aged; Myocardial Infarction; Naproxen; Randomized Controlled Trials as Topic; Stroke; Sulfones	2020

Trials

28 trial(s) available for aspirin and rofecoxib

Article	Year
Specific inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen. Alimentary pharmacology & therapeutics, 1999, Volume: 13, Issue:6 Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Duodenal Ulcer; Enzyme Inhibitors; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases; Stomach Ulcer; Sulfones; Thromboxanes	1999
A new cyclooxygenase-2 inhibitor, rofecoxib (VIOXX), did not alter the antiplatelet effects of low-dose aspirin in healthy volunteers. Journal of clinical pharmacology, 2000, Volume: 40, Issue:12 Pt 2 Topics: Adolescent; Adult; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Female; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Sulfones; Thromboxane B2	2000
Safety of a specific COX-2 inhibitor in aspirin-induced asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2001, Volume: 31, Issue:2 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Isoenzymes; Lactones; Leukotriene E4; Male; Membrane Proteins; Middle Aged; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Sulfones	2001
Lack of cross-reactivity between rofecoxib and aspirin in aspirin-sensitive patients with asthma. The Journal of allergy and clinical immunology, 2001, Volume: 108, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cross Reactions; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Hypersensitivity; Forced Expiratory Volume; Humans; Lactones; Sulfones	2001
Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. The New England journal of medicine, 2001, Dec-20, Volume: 345, Issue:25 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Drug Interactions; Drug Therapy, Combination; Humans; Ibuprofen; Isoenzymes; Lactones; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Sulfones; Thromboxane B2	2001
Cyclooxygenase-2 inhibitor for pain management in osteoid osteoma. Clinical orthopaedics and related research, 2001, Issue:393 Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bone Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Osteoma, Osteoid; Pain; Pain Measurement; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Sulfones	2001
Safety of rofecoxib in subjects with a history of adverse cutaneous reactions to aspirin and/or non-steroidal anti-inflammatory drugs. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2002, Volume: 32, Issue:3 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Evaluation; Drug Hypersensitivity; Female; Humans; Immunoglobulin E; Italy; Lactones; Male; Middle Aged; Skin Diseases; Sulfones; Treatment Outcome; Urticaria	2002
Effects of cyclooxygenases inhibitors on vasoactive prostanoids and thrombin generation at the site of microvascular injury in healthy men. Arteriosclerosis, thrombosis, and vascular biology, 2003, Jun-01, Volume: 23, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bleeding Time; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Endothelium, Vascular; Fibrinolytic Agents; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Naproxen; Prostaglandin-Endoperoxide Synthases; Sulfones; Thrombin; Thromboxane B2	2003
Gastrointestinal tolerability and effectiveness of rofecoxib versus naproxen in the treatment of osteoarthritis: a randomized, controlled trial. Annals of internal medicine, 2003, Oct-07, Volume: 139, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Humans; Hypertension; Lactones; Male; Middle Aged; Naproxen; Osteoarthritis; Prospective Studies; Sulfones	2003
Effect of cyclooxygenase-2 inhibition with rofecoxib on endothelial dysfunction and inflammatory markers in patients with coronary artery disease. Journal of the American College of Cardiology, 2003, Nov-19, Volume: 42, Issue:10 Topics: Aspirin; Biomarkers; Brachial Artery; Coronary Artery Disease; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Endothelium, Vascular; Hemodynamics; Humans; Lactones; Sulfones; Treatment Outcome	2003
Safety of cyclooxygenase 2 inhibitors and increased leukotriene synthesis in chronic idiopathic urticaria with sensitivity to nonsteroidal anti-inflammatory drugs. Archives of dermatology, 2003, Volume: 139, Issue:12 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy; Celecoxib; Computer Graphics; Cross-Over Studies; Cyclooxygenase Inhibitors; Cysteine; Double-Blind Method; Drug Eruptions; Female; Humans; Lactones; Leukotriene E4; Leukotrienes; Male; Middle Aged; Multivariate Analysis; Naproxen; Prospective Studies; Pyrazoles; Serine Endopeptidases; Skin; Sulfonamides; Sulfones; Treatment Outcome; Tryptases; Urticaria	2003
Comparison of some effects of acetylsalicylic acid and rofecoxib during orthodontic tooth movement. American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2004, Volume: 125, Issue:3 Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Female; Follow-Up Studies; Gingival Crevicular Fluid; Humans; Lactones; Male; Pain, Postoperative; Serial Extraction; Statistics, Nonparametric; Sulfones; Tooth Movement Techniques	2004
Acetylsalicylic acid, diclofenac, and lornoxicam, but not rofecoxib, affect platelet CD 62 expression. Anesthesia and analgesia, 2004, Volume: 98, Issue:4 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Flow Cytometry; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Piroxicam; Platelet Function Tests; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Selectins; Sulfones	2004
Safety of selective COX-2 inhibitors in aspirin/nonsteroidal anti-inflammatory drug-intolerant patients: comparison of nimesulide, meloxicam, and rofecoxib. The Journal of asthma : official journal of the Association for the Care of Asthma, 2004, Volume: 41, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cyclooxygenase Inhibitors; Drug Hypersensitivity; Female; Humans; Immunologic Tests; Lactones; Male; Meloxicam; Middle Aged; Single-Blind Method; Sulfonamides; Sulfones; Thiazines; Thiazoles; Treatment Outcome; Urticaria	2004
Ulcer formation with low-dose enteric-coated aspirin and the effect of COX-2 selective inhibition: a double-blind trial. Gastroenterology, 2004, Volume: 127, Issue:2 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Gastric Mucosa; Humans; Ibuprofen; Incidence; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Risk Factors; Stomach Ulcer; Sulfones; Tablets, Enteric-Coated	2004
Impact of prolonged cyclooxygenase-2 inhibition on inflammatory markers and endothelial function in patients with ischemic heart disease and raised C-reactive protein: a randomized placebo-controlled study. Circulation, 2004, Aug-24, Volume: 110, Issue:8 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Biomarkers; Brachial Artery; C-Reactive Protein; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Endothelium, Vascular; Female; Humans; Inflammation; Interleukin-6; Lactones; Male; Matrix Metalloproteinase 9; Membrane Proteins; Middle Aged; Myocardial Ischemia; P-Selectin; Prostaglandin-Endoperoxide Synthases; Sulfones; Vasodilation	2004
Tolerability of three selective cyclo-oxygenase-2 inhibitors, meloxicam, celecoxib and rofecoxib in NSAID-sensitive patients. European annals of allergy and clinical immunology, 2004, Volume: 36, Issue:6 Topics: Adolescent; Adult; Aged; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Celecoxib; Cross Reactions; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Hypersensitivity; Female; Forced Expiratory Volume; Hemodynamics; Humans; Isoenzymes; Lactones; Male; Meloxicam; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Recurrence; Rhinitis, Allergic, Perennial; Single-Blind Method; Sulfonamides; Sulfones; Thiazines; Thiazoles; Urticaria	2004
Effect of non-selective, non-steroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors on the PFA-100 closure time. Anaesthesia, 2004, Volume: 59, Issue:11 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Perioperative Care; Piroxicam; Platelet Function Tests; Prostaglandin-Endoperoxide Synthases; Sulfones	2004
Safety of high-dose rofecoxib in patients with aspirin-exacerbated respiratory disease. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2004, Volume: 93, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cross Reactions; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Hypersensitivity; Humans; Lactones; Respiratory Hypersensitivity; Sulfones; Treatment Outcome	2004
Cyclooxygenase-2 specific inhibitors and upper gastrointestinal tolerability in patients with osteoarthritis receiving concomitant low dose aspirin: pooled analysis of 2 trials. The Journal of rheumatology, 2005, Volume: 32, Issue:1 Topics: Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Gastrointestinal Diseases; Humans; Hypertension; Lactones; Osteoarthritis; Pyrazoles; Sulfonamides; Sulfones	2005
Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. The New England journal of medicine, 2005, Mar-17, Volume: 352, Issue:11 Topics: Adenomatous Polyps; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Incidence; Lactones; Male; Middle Aged; Proportional Hazards Models; Risk; Secondary Prevention; Single-Blind Method; Sulfones; Thrombosis	2005
Oral aspirin challenges in patients with a history of intolerance to single non-steroidal anti-inflammatory drugs. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2005, Volume: 35, Issue:6 Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Cyclooxygenase Inhibitors; Drug Evaluation; Female; Humans; Lactones; Male; Middle Aged; ortho-Aminobenzoates; Recurrence; Single-Blind Method; Sulfonamides; Sulfones; Tramadol; Urticaria	2005
Determinants of platelet activation in Alzheimer's disease. Neurobiology of aging, 2007, Volume: 28, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspirin; Body Mass Index; C-Reactive Protein; Case-Control Studies; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Cyclooxygenase 2 Inhibitors; Dinoprost; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-6; Lactones; Logistic Models; Male; Odds Ratio; Platelet Activation; Radioimmunoassay; Sulfones; Thromboxane B2; Tumor Necrosis Factor-alpha; Vitamin E	2007
Nasal and bronchial tolerability of Rofecoxib in patients with aspirin induced asthma. European annals of allergy and clinical immunology, 2006, Volume: 38, Issue:1 Topics: Adult; Aspirin; Asthma; Bronchoconstriction; Cyclooxygenase 2 Inhibitors; Female; Forced Expiratory Volume; Humans; Lactones; Lung; Male; Middle Aged; Nose; Respiratory Function Tests; Rhinomanometry; Sulfones	2006
The effects of esomeprazole combined with aspirin or rofecoxib on prostaglandin E2 production in patients with Barrett's oesophagus. Alimentary pharmacology & therapeutics, 2006, Apr-01, Volume: 23, Issue:7 Topics: Adult; Aged; Aspirin; Barrett Esophagus; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Therapy, Combination; Enzyme Inhibitors; Esomeprazole; Esophagitis; Esophagus; Female; Humans; Lactones; Male; Middle Aged; Proliferating Cell Nuclear Antigen; Prospective Studies; Sulfones	2006
Use of ketoprofen oral challenges to detect cross-reactors among patients with a history of aspirin-induced urticaria. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 97, Issue:2 Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross Reactions; Cyclooxygenase Inhibitors; Drug Hypersensitivity; Female; Humans; Ketoprofen; Lactones; Male; Middle Aged; Placebos; Sulfonamides; Sulfones; Tramadol; Urticaria	2006
Effects of selective cyclooxygenase isoform inhibition on systemic prostacyclin synthesis and on platelet function at rest and after exercise in healthy volunteers. Platelets, 2007, Volume: 18, Issue:5 Topics: Adenosine Diphosphate; Adult; Aspirin; Atherosclerosis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Endothelium; Epoprostenol; Exercise; Humans; Isoenzymes; Lactones; Male; Platelet Activation; Rest; Risk Factors; Sulfones; Thrombosis; Thromboxane B2	2007
Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Dec-01, Volume: 31, Issue:34 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemotherapy, Adjuvant; Class I Phosphatidylinositol 3-Kinases; Colectomy; Colorectal Neoplasms; Cyclooxygenase 2; Disease-Free Survival; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Humans; Kaplan-Meier Estimate; Lactones; Male; Middle Aged; Multivariate Analysis; Mutation; Neoplasm Recurrence, Local; Patient Selection; Phenotype; Phosphatidylinositol 3-Kinases; Proportional Hazards Models; Risk Assessment; Risk Factors; Sulfones; Time Factors; Treatment Outcome	2013

Other Studies

63 other study(ies) available for aspirin and rofecoxib

Article	Year
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. Journal of natural products, 2002, Volume: 65, Issue:11 Topics: Acrolein; Alkaloids; Animals; Anthraquinones; Aspirin; Biological Assay; Catalysis; Cinnamomum zeylanicum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eugenol; Flavonoids; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Lactones; Models, Molecular; Nitrobenzenes; Oleanolic Acid; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Pyrogallol; Steroids; Sulfonamides; Sulfones; Syzygium; Terpenes; Triterpenes; Ursolic Acid	2002
A new class of acyclic 2-alkyl-1,1,2-triaryl (Z)-olefins as selective cyclooxygenase-2 inhibitors. Journal of medicinal chemistry, 2004, Nov-18, Volume: 47, Issue:24 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzene Derivatives; Cyclooxygenase 2; Ethylenes; Isoenzymes; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Rats; Stereoisomerism; Structure-Activity Relationship	2004
Expanding the ChemGPS chemical space with natural products. Journal of natural products, 2005, Volume: 68, Issue:7 Topics: Biological Products; Combinatorial Chemistry Techniques; Computer Graphics; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship	2005
Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases. Journal of medicinal chemistry, 2006, Mar-09, Volume: 49, Issue:5 Topics: Administration, Oral; Alkynes; Analgesics; Animals; Arachidonate 15-Lipoxygenase; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Lipoxygenase Inhibitors; Mice; Models, Molecular; Pain Measurement; Rats; Structure-Activity Relationship	2006
2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures. European journal of medicinal chemistry, 2008, Volume: 43, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Disease; Cyclooxygenase Inhibitors; Drug Design; Edema; Female; Foot; Formaldehyde; Inflammation; Male; Rats; Rats, Sprague-Dawley; Thiazoles	2008
Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies. Bioorganic & medicinal chemistry, 2007, Nov-01, Volume: 15, Issue:21 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Drug Design; Humans; Imides; Nitric Oxide; Nitric Oxide Donors; Prodrugs; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship; Sulfones	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers. Bioorganic & medicinal chemistry, 2008, Feb-15, Volume: 16, Issue:4 Topics: Alkynes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Design; Humans; Inhibitory Concentration 50; Structure-Activity Relationship	2008
Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies. Bioorganic & medicinal chemistry, 2008, Mar-15, Volume: 16, Issue:6 Topics: Acrylates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Esters; Nitric Oxide; Nitric Oxide Donors; Prodrugs; Rats; Serum; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors. Bioorganic & medicinal chemistry, 2011, Nov-01, Volume: 19, Issue:21 Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Humans; Inhibitory Concentration 50; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Molecular Structure; Rats; Rats, Wistar; Structure-Activity Relationship; Thiazoles	2011
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker. Bioorganic & medicinal chemistry letters, 2013, Jan-01, Volume: 23, Issue:1 Topics: Acridines; Acridones; Biomarkers, Tumor; Celecoxib; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Fluorescent Dyes; Humans; Ibuprofen; Microscopy, Confocal; Protein Binding; Pyrazoles; Rhodamines; Structure-Activity Relationship; Sulfonamides	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism. European journal of medicinal chemistry, 2014, Sep-12, Volume: 84 Topics: 5-Lipoxygenase-Activating Proteins; Aminophenols; Cyclooxygenase 2; Dose-Response Relationship, Drug; Eicosanoids; Enzyme Inhibitors; HeLa Cells; Humans; Molecular Structure; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured; U937 Cells	2014
COX-2 inhibitors. Lancet (London, England), 1999, Jan-23, Volume: 353, Issue:9149 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Crystallography, X-Ray; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Lactones; Membrane Proteins; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones	1999
Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers. Microscopy research and technique, 2001, Jun-01, Volume: 53, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Gastrins; Indomethacin; Interleukin-1; Isoenzymes; Lactones; Male; Meloxicam; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Rats; Rats, Wistar; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stilbenes; Stomach Ulcer; Sulfonamides; Sulfones; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha	2001
Rofecoxib as an alternative in aspirin hypersensitivity. Allergy, 2001, Volume: 56, Issue:8 Topics: Adult; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Hypersensitivity; Humans; Isoenzymes; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Retreatment; Sulfones	2001
A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin. Proceedings of the National Academy of Sciences of the United States of America, 2001, Dec-04, Volume: 98, Issue:25 Topics: Acetylation; Animals; Aspirin; Blood Platelets; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Etoricoxib; Humans; Ibuprofen; In Vitro Techniques; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Sheep; Sulfonamides; Sulfones	2001
Bioactivity of alkamides isolated from Echinacea purpurea (L.) Moench. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2002, Volume: 9, Issue:3 Topics: Aedes; Amides; Animals; Anti-Inflammatory Agents; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Echinacea; Ibuprofen; Isoenzymes; Lactones; Lethal Dose 50; Naproxen; Phytotherapy; Plant Extracts; Plant Roots; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones	2002
Safety of a cyclooxygenase-2 inhibitor in patients with aspirin-sensitive asthma. Chest, 2002, Volume: 121, Issue:6 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cyclooxygenase Inhibitors; Female; Humans; Lactones; Male; Middle Aged; Single-Blind Method; Sulfones	2002
Are selective COX 2 inhibitors superior to traditional NSAIDs? Both the CLASS and VIGOR trials support the COX 2 hypothesis. BMJ (Clinical research ed.), 2002, Jul-20, Volume: 325, Issue:7356 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Humans; Lactones; Peptic Ulcer; Pyrazoles; Risk Factors; Sulfonamides; Sulfones	2002
Cardiovascular thrombotic events in controlled, clinical trials of rofecoxib. Circulation, 2002, Jul-30, Volume: 106, Issue:5 Topics: Aspirin; Cardiovascular Diseases; Controlled Clinical Trials as Topic; Cyclooxygenase Inhibitors; Humans; Lactones; Reproducibility of Results; Research Design; Sulfones; Thrombosis	2002
Isomeric acetoxy analogues of rofecoxib: a novel class of highly potent and selective cyclooxygenase-2 inhibitors. Bioorganic & medicinal chemistry letters, 2002, Oct-07, Volume: 12, Issue:19 Topics: Acetylation; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Isomerism; Lactones; Membrane Proteins; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Sulfones	2002
Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage. Gastroenterology, 2002, Volume: 123, Issue:5 Topics: Animals; Aspirin; Celecoxib; Cell Adhesion; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Resistance; Gastric Mucosa; Hydroxyeicosatetraenoic Acids; Isoenzymes; Lactones; Leukocytes; Lipoxins; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Stomach; Sulfonamides; Sulfones	2002
Impaired monocyte function in cancer patients: restoration with a cyclooxygenase-2 inhibitor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carcinoma, Squamous Cell; Cell Movement; Cyclooxygenase Inhibitors; Head and Neck Neoplasms; Indomethacin; Lactones; Monocytes; Prostaglandin-Endoperoxide Synthases; Receptors, CCR5; Sulfones	2003
Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis. American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 285, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Adhesion; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Susceptibility; Gastric Mucosa; Gastritis; Hydroxyeicosatetraenoic Acids; Isoenzymes; Lactones; Leukocytes; Lipoxins; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach Ulcer; Sulfones	2003
Cyclooxygenase-2 inhibitors in aspirin-induced asthma. Chest, 2003, Volume: 123, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Sulfones	2003
[Acute ulcerative colitis in a patient treated with rofecoxib who took aspirin as self-medication]. Gastroenterologie clinique et biologique, 2003, Volume: 27, Issue:5 Topics: Abdominal Pain; Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Biopsy; Colitis, Ulcerative; Drug Synergism; Female; Humans; Lactones; Middle Aged; Sciatica; Self Medication; Sulfones	2003
Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents. Diabetologia, 2003, Volume: 46, Issue:8 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 1; Graft Survival; Islets of Langerhans Transplantation; Lactones; Mice; Mice, Inbred NOD; Sulfones; Transplantation, Heterologous	2003
Summaries for patients. Gastrointestinal side effects of rofecoxib and naproxen. Annals of internal medicine, 2003, Oct-07, Volume: 139, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Humans; Hypertension; Lactones; Male; Middle Aged; Naproxen; Osteoarthritis; Prospective Studies; Sulfones	2003
Evaluation of effects of rofecoxib on platelet function in an in vitro model of thrombosis with circulating human blood. European journal of clinical investigation, 2004, Volume: 34, Issue:4 Topics: Adenosine Diphosphate; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Cell Adhesion; Collagen; Cyclooxygenase Inhibitors; Endothelium; Humans; Lactones; Platelet Aggregation; Sulfones; Thrombosis	2004
Fibronectin-induced COX-2 mediates MMP-2 expression and invasiveness of rhabdomyosarcoma. Biochemical and biophysical research communications, 2004, May-28, Volume: 318, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Count; Cell Line, Tumor; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Induction; Fibronectins; Humans; Isoenzymes; Lactones; Laminin; Luciferases; Matrix Metalloproteinase 2; Membrane Proteins; Neoplasm Invasiveness; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Rhabdomyosarcoma; Sulfones; Up-Regulation	2004
Differential up-regulation of cytosolic and membrane-bound heat shock protein 70 in tumor cells by anti-inflammatory drugs. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, May-15, Volume: 10, Issue:10 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Aspirin; Celecoxib; Cell Line, Tumor; Cell Membrane; Cell Survival; Cytoplasm; Cytosol; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Flow Cytometry; Fluorescein-5-isothiocyanate; Granzymes; HSP70 Heat-Shock Proteins; Humans; Immunoblotting; Immunotherapy; Insulin; Kinetics; Lactones; Models, Chemical; Neoplasms; Pioglitazone; Pyrazoles; Serine Endopeptidases; Sulfonamides; Sulfones; Thiazolidinediones; Up-Regulation	2004
Nonsteroidal antiinflammatory drugs and the risk of myocardial infarction in the general population. Circulation, 2004, Jun-22, Volume: 109, Issue:24 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiotonic Agents; Case-Control Studies; Cohort Studies; Comorbidity; Coronary Disease; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Drug Synergism; Drug Utilization; Female; Follow-Up Studies; Humans; Ibuprofen; Lactones; Male; Middle Aged; Myocardial Infarction; Naproxen; Odds Ratio; Risk Factors; Spain; Sulfones	2004
[Prescribing patterns of rofecoxib in the primary care setting: results of a French survey]. La Revue de medecine interne, 2004, Volume: 25, Issue:10 Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Arthritis; Arthritis, Rheumatoid; Aspirin; Chi-Square Distribution; Cyclooxygenase Inhibitors; Data Interpretation, Statistical; Drug Prescriptions; Family Practice; France; Gastrointestinal Hemorrhage; Humans; Lactones; Middle Aged; Platelet Aggregation Inhibitors; Primary Health Care; Proton Pump Inhibitors; Risk Factors; Sulfones	2004
Anti-inflammatory treatment with acetylsalicylate or rofecoxib is not neuroprotective in Huntington's disease transgenic mice. Neurobiology of disease, 2004, Volume: 17, Issue:2 Topics: Acoustic Stimulation; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Body Weight; Corpus Striatum; Cyclooxygenase Inhibitors; Huntington Disease; Lactones; Mice; Mice, Transgenic; Motor Activity; Neural Inhibition; Neuroprotective Agents; Prosencephalon; Reflex, Startle; Sulfones	2004
Effect of chronic intake of NSAIDs and cyclooxygenase 2-selective inhibitors on esophageal cancer incidence. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2004, Volume: 2, Issue:10 Topics: Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Celecoxib; Cohort Studies; Cyclooxygenase Inhibitors; Databases as Topic; Esophageal Neoplasms; Female; Humans; Incidence; Lactones; Logistic Models; Male; Pyrazoles; Quebec; Risk Factors; Sex Factors; Sulfonamides; Sulfones	2004
Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model. Fundamental & clinical pharmacology, 2004, Volume: 18, Issue:5 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Flurbiprofen; Ibuprofen; Isoenzymes; Lactones; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones; Thrombosis	2004
Colorectal cancer and Coxibs. Revista espanola de enfermedades digestivas, 2004, Volume: 96, Issue:10 Topics: 1,2-Dimethylhydrazine; Animals; Aspirin; Carcinogens; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Humans; Lactones; Sulfones	2004
Influence of rofecoxib on experimental colonic carcinogenesis in rats. Revista espanola de enfermedades digestivas, 2004, Volume: 96, Issue:10 Topics: 1,2-Dimethylhydrazine; Animals; Aspirin; Carcinogens; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Isoenzymes; Lactones; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sulfones	2004
Rofecoxib, Merck, and the FDA. The New England journal of medicine, 2004, Dec-30, Volume: 351, Issue:27 Topics: Aspirin; Cardiovascular Diseases; Celecoxib; Cyclooxygenase Inhibitors; Drug Approval; Drug Interactions; Gastrointestinal Diseases; History, 20th Century; History, 21st Century; Humans; Lactones; Platelet Aggregation Inhibitors; Pyrazoles; Sulfonamides; Sulfones; United States; United States Food and Drug Administration	2004
Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction. Annals of internal medicine, 2005, Feb-01, Volume: 142, Issue:3 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bias; Case-Control Studies; Celecoxib; Confounding Factors, Epidemiologic; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Ibuprofen; Lactones; Male; Middle Aged; Myocardial Infarction; Naproxen; Odds Ratio; Pyrazoles; Risk Factors; Sulfonamides; Sulfones	2005
The withdrawal of rofecoxib. Pharmacoepidemiology and drug safety, 2005, Volume: 14, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Cyclooxygenase 2 Inhibitors; Death, Sudden, Cardiac; Drug Industry; Humans; Lactones; Naproxen; Pharmacoepidemiology; Product Surveillance, Postmarketing; Sulfones	2005
Cyclooxygenase-2 inhibitors attenuate angiotensin II-induced oxidative stress, hypertension, and cardiac hypertrophy in rats. Hypertension (Dallas, Tex. : 1979), 2005, Volume: 45, Issue:6 Topics: Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiomegaly; Cells, Cultured; Cyclooxygenase Inhibitors; Hypertension; Lactones; Male; Myocardium; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones	2005
Protective role of heat shock protein 27 in gastric mucosal injury. The Journal of pathology, 2005, Volume: 207, Issue:2 Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Drug Therapy, Combination; Epithelial Cells; Female; Gastric Mucosa; Heat-Shock Proteins; Helicobacter Infections; Helicobacter pylori; Humans; Immunohistochemistry; Indomethacin; Injections, Intraperitoneal; Lactones; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Stomach Ulcer; Sulfones	2005
Cyclooxygenase-2 inhibition in colon experimental carcinogenesis. Revista espanola de enfermedades digestivas, 2005, Volume: 97, Issue:9 Topics: 1,2-Dimethylhydrazine; Animals; Aspirin; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Lactones; Male; Rats; Rats, Sprague-Dawley; Sulfones	2005
NSAIDs and cardiovascular risk. Cell metabolism, 2005, Volume: 2, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular System; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Hypertension; Lactones; Sulfones; Thromboxane A2	2005
[Role of cyclo-oxygenases in the effects of angiotensin II]. Medecine sciences : M/S, 2006, Volume: 22, Issue:1 Topics: Angiotensin II; Animals; Aspirin; Cardiovascular Diseases; Cyclooxygenase Inhibitors; Humans; Lactones; Models, Biological; Oxidative Stress; Sulfones	2006
Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:3 Topics: Aspirin; Blood Platelets; Blood Proteins; Calcimycin; Calcium; Celecoxib; Cell Line; Cerebrospinal Fluid Proteins; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Indomethacin; Ionophores; Lactones; Meloxicam; Naproxen; Organ Specificity; Organic Chemicals; Protein Binding; Pyrazoles; Sodium Salicylate; Sulfonamides; Sulfones; Synovial Fluid; Thiazines; Thiazoles; Thromboxane A2	2006
Rofecoxib, as a safe alternative for acetyl salicylic acid/nonsteroidal anti-inflammatory drug-intolerant patients. Journal of investigational allergology & clinical immunology, 2006, Volume: 16, Issue:1 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2 Inhibitors; Drug Hypersensitivity; Female; Humans; Lactones; Male; Middle Aged; Single-Blind Method; Sulfones	2006
Balancing the cyclooxygenase portfolio. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2006, May-23, Volume: 174, Issue:11 Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2 Inhibitors; Drug Administration Schedule; Drug Approval; Drug Interactions; Humans; Lactones; Myocardial Infarction; Risk Assessment; Sulfones	2006
The lipoxygenase-cyclooxygenase inhibitor licofelone prevents thromboxane A2-mediated cardiovascular derangement triggered by the inflammatory peptide fMLP in the rabbit. European journal of pharmacology, 2006, Sep-28, Volume: 546, Issue:1-3 Topics: Acetates; Animals; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Electrocardiography; Heart Rate; Inflammation; Lactones; Leukotriene B4; Lipoxygenase Inhibitors; Male; Myocardial Ischemia; N-Formylmethionine Leucyl-Phenylalanine; Pyrroles; Rabbits; Sulfones; Thromboxane A2; Time Factors	2006
Better ways to target pain. Scientific American, 2007, Volume: 296, Issue:1 Topics: Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2 Inhibitors; Epoprostenol; Humans; Intramolecular Oxidoreductases; Lactones; Mice; Mice, Knockout; Prostaglandin-E Synthases; Prostaglandins; Sulfones	2007
NSAIDs, Myocardial infarction, rebound effect and similitude. Homeopathy : the journal of the Faculty of Homeopathy, 2007, Volume: 96, Issue:1 Topics: Antidepressive Agents; Aspirin; Bronchodilator Agents; Dose-Response Relationship, Drug; Evidence-Based Medicine; Homeopathy; Humans; Iatrogenic Disease; Lactones; Materia Medica; Research Design; Sulfones	2007
Risks and benefits of COX-2 inhibitors vs non-selective NSAIDs: does their cardiovascular risk exceed their gastrointestinal benefit? A retrospective cohort study. Rheumatology (Oxford, England), 2007, Volume: 46, Issue:3 Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Prescriptions; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Hospitalization; Humans; Lactones; Male; Myocardial Infarction; Naproxen; Pyrazoles; Quebec; Retrospective Studies; Risk Assessment; Sulfonamides; Sulfones	2007
Reduced risk of human lung cancer by selective cyclooxygenase 2 (COX-2) blockade: results of a case control study. International journal of biological sciences, 2007, Jun-13, Volume: 3, Issue:5 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Celecoxib; Chemoprevention; Cyclooxygenase 2 Inhibitors; Female; Humans; Ibuprofen; Lactones; Logistic Models; Lung Neoplasms; Male; Middle Aged; Odds Ratio; Ohio; Pyrazoles; Retrospective Studies; Risk Factors; Sulfonamides; Sulfones	2007
Cardiovascular, rheumatologic, and pharmacologic predictors of stroke in patients with rheumatoid arthritis: a nested, case-control study. Arthritis and rheumatism, 2008, Aug-15, Volume: 59, Issue:8 Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Aspirin; Brain Ischemia; Case-Control Studies; Comorbidity; Female; Humans; Hypertension; Lactones; Logistic Models; Male; Middle Aged; Myocardial Infarction; Predictive Value of Tests; Risk Factors; Severity of Illness Index; Stroke; Sulfones; Tumor Necrosis Factor-alpha	2008
COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Volume: 22, Issue:11 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aspirin; Asthma; Bronchi; Bronchoconstriction; Bronchoconstrictor Agents; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Hypersensitivity; Humans; Lactones; Membrane Proteins; Mice; Mice, Knockout; Respiratory Mucosa; Sulfones; Vasoconstrictor Agents	2008
Curcumin potentiates the anti-inflammatory activity of cyclooxygenase inhibitors in the cotton pellet granuloma pouch model. Methods and findings in experimental and clinical pharmacology, 2009, Volume: 31, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Curcumin; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Granuloma; Lactones; Male; Medicine, Traditional; Rats; Rats, Wistar; Sulfones; Tumor Necrosis Factor-alpha	2009
Antagonism of the antithrombotic and anti-atherosclerotic actions of aspirin by rofecoxib in the cholesterol-fed rabbit. British journal of pharmacology, 2011, Volume: 164, Issue:2b Topics: Animal Feed; Animals; Aorta; Aspirin; Atherosclerosis; Cholesterol; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Drug Antagonism; Epoprostenol; Female; Fibrinolytic Agents; Immunohistochemistry; Lactones; Male; Platelet Aggregation Inhibitors; Rabbits; Sulfones; Thrombosis; Thromboxanes	2011
[Antitumor effects of sulindac in ovarian cell cultures]. Ginekologia polska, 2011, Volume: 82, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Cell Cycle; Cell Size; Cell Survival; Colorimetry; Female; Humans; Lactones; Ovarian Neoplasms; Sulfonamides; Sulfones; Sulindac; Tumor Cells, Cultured	2011
Aspirin therapy for colorectal cancer with PIK3CA mutation: simply complex! Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Dec-01, Volume: 31, Issue:34 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Class I Phosphatidylinositol 3-Kinases; Colorectal Neoplasms; Female; Humans; Lactones; Male; Mutation; Neoplasm Recurrence, Local; Phosphatidylinositol 3-Kinases; Sulfones	2013