aspirin and nitroaspirin

aspirin has been researched along with nitroaspirin in 125 studies

Research

Studies (125)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (8.00)	18.2507
2000's	103 (82.40)	29.6817
2010's	12 (9.60)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bos, C; de Esch, IJ; Hulsman, N; Jongejan, A; Leurs, R; Medema, JP; Richel, D; Smit, MJ; Wijtmans, M	1
Bonapace, S; Degan, M; Fontana, L; Gaino, S; Lechi, A; Lechi, C; Minuz, P; Tommasoli, R; Zuliani, V	1
Andrioli, G; Bellavite, P; Benoni, G; Degan, M; Gaino, S; Lechi, A; Lechi, C; Minuz, P; Ortolani, R; Tommasoli, R; Zuliani, V	1
Cirino, G; Del Soldato, P; McKnight, W; Wallace, JL; Wilson, TL	1
Bak, AW; Calignano, A; Cirino, G; Del Soldato, P; Li, P; McKnight, W; Wallace, JL	1
Kitamura, M; Konaka, A; Sugawa, Y; Takeuchi, K; Ukawa, H	1
Cirino, G; Del Soldato, P; Dicay, M; McKnight, W; Muscara, MN; Wallace, JL	1
Araki, H; Mizoguchi, H; Suzuki, K; Takeuchi, K; Ukawa, H; Yamamoto, H	1
Antonelli, E; Cirino, G; Coata, G; Distrutti, E; Federici, B; Fiorucci, S; Morelli, A; Morelli, O; Renzo, GD; Santucci, L; Soldato, PD	1
Antonelli, E; Del Soldato, P; Federici, B; Fiorucci, S; Mannucci, R; Miglietti, M; Morelli, A; Morelli, O; Santucci, L	1
del Soldato, P; Pinto, A; Sorrentino, R	1
Antonelli, E; Del Sero, G; Del Soldato, P; Distrutti, E; Federici, B; Fiorucci, S; Morelli, A; Morelli, O; Romani, L; Santucci, L	1
al-Swayeh, OA; Clifford, RH; del Soldato, P; Moore, PK	1
Bernareggi, M; Berti, F; Berti, M; Colonna, VD; Del Soldato, P; Rossoni, G	1
Nakaki, T	1
Del Soldato, P; Emerson, M; Gresele, P; Leone, M; Mezzasoma, AM; Momi, S; Page, CP; Paul, W	1
Grosser, N; Schröder, H	1
Bing, RJ; Johnson, PE; Kakar, NR; Vina, ER; Yamamoto, T	2
Fujita, A; Takeuchi, K; Tashima, K; Umeda, M	1
Cirino, G; Familiari, L; Fiorucci, S; Mencarelli, A; Morelli, A; Santucci, L; Soldato, PD	1
Bing, RJ; Yamamoto, T	1
Cirino, G; Condorelli, M; Del Soldato, P; Ignarro, LJ; Napoli, C; Pinto, A; Sica, V; Sorrentino, R	1
Bernareggi, M; Berti, F; Colonna, VD; Manfredi, B; Rossoni, G	1
Ambrosini, MV; Del Soldato, P; Fredduzzi, S; Mariucci, G; Tantucci, M	1
Fiorucci, S	1
Al-Swayeh, OA; Keeble, J; Moore, PK	1
del Soldato , P; Dicay, M; Lovren, F; McKnight, W; Muscará, MN; Triggle, CR; Wallace, JL	1
Kato, S; Komoike, Y; Suzuki, K; Takeuchi, K; Ukawa, H	1
Aldini, G; Carini, M; Facino, RM; Orioli, M; Stefani, R	1
Degan, M; Gaino, S; Lechi, A; Meneguzzi, A; Minuz, P; Santonastaso, CL; Soldato, PD; Zuliani, V	1
Abete, P; Aldini, G; Bonaduce, D; Condorelli, G; Condorelli, M; D'Armiento, FP; de Nigris, F; de Rosa, G; Ignarro, LJ; Lerman, LO; Maffei, R; Mignogna, C; Napoli, C; Rengo, F; Sica, V; Wallace, JL	1
Del Soldato, P; Miller, AM; Wainwright, CL; Work, LM	1
Del Soldato, P; Felix, CC; Olds, CL; Pieper, GM; Siebeneich, W	1
Aldini, G; Carini, M; Maffei Facino, R; Orioli, M	1
Fiorucci, S; Ignarro, LJ; Wallace, JL	1
del Soldato, P; Distrutti, E; Fiorucci, S; Mannucci, R; Mencarelli, A; Moncada, S; Morelli, A	1
Berti, F; Del Soldato, P; Manfredi, B; Rossoni, G	1
Ackah, E; Condorelli, M; Crimi, E; D'Armiento, FP; De Nigris, F; Del Soldato, P; Napoli, C; Sessa, WC	1
del Soldato, P; Fiorucci, S; Lechi, A; Mencarelli, A; Meneguzzi, A; Minuz, P; Morelli, A	1
Del Soldato, P; Faccino, RM; Fiorucci, S; Gresele, P; Morelli, A; Santucci, L	1
Peura, DA	1
Angelini, GD; Ascione, R; Capoun, R; Jeremy, JY; Shukla, N; Talpahewa, S	1
Amadori, D; Medri, L; Ricotti, L; Tesei, A; Ulivi, P; Zoli, W	1
Brzozowski, T; Duda, A; Hahn, EG; Konturek, P; Konturek, SJ; Kwiecień, S; Pajdo, R; Ptak, A; Sliwowski, Z	1
Del Soldato, P; Fiorucci, S	1
Gresele, P; Mezzasoma, AM; Momi, S	1
Kalofonos, H; Lebovics, E; Rigas, B; Vagenakis, AG	1
Evans, R	1
del Soldato, P; Fiorucci, S; Morelli, A; Romano, M; Santucci, L; Sardina, M; Wallace, JL	1
Brzozowski, T; Hahn, EG; Kania, J; Konturek, PC; Konturek, SJ	1
Berti, F; Del Soldato, P; Manfredi, B; Polvani, G; Rossoni, G	1
Bertuglia, S; Del Soldato, P; Giusti, A	1
Di Napoli, M; Papa, F	1
Breen, CG; Clancy, JM; Gilmer, JF; Murphy, MA; Ryder, SA; Shannon, JA	1
Corazzi, T; Del Soldato, P; Gresele, P; Leone, M; Roberti, R	1
del Soldato, P; Dicay, M; Fiorucci, S; McKnight, W; Mencarelli, A; Wallace, JL; Zamuner, SR	1
Mann, NS	1
Baldoni, M; Del Soldato, P; Distrutti, E; Fiorucci, S; Lorenzo, AR; Mencarelli, A; Morelli, A; Rizzo, G; Wallace, JL	1
Caira, MR; Foppoli, A; Gazzaniga, A; Giordano, F; Maroni, A; Sangalli, ME	1
Fiorucci, S; Perini, R; Wallace, JL	1
Aldini, G; Carini, M; Facino, RM; Orioli, M; Piccoli, A; Tocchetti, P	1
Aldini, G; Carini, M; Maffei Facino, R; Orioli, M; Piccoli, A; Rossoni, G	1
Butcher, C; Evans, CE	1
Cattaneo, M	1
Baldoni, M; del Soldato, P; Distrutti, E; Fiorucci, S; Mencarelli, A; Morelli, A	1
Angelini, G; Jeremy, JY; Muzaffar, S; Shukla, N	1
Del Soldato, P; Emanueli, C; Madeddu, P; Monopoli, A; Ongini, E; Salis, MB; Van Linthout, S	1
del Soldato, P; Fiorucci, S; Lechi, A; Mencarelli, A; Meneguzzi, A; Minuz, P; Morelli, A; Renga, B	1
Levin, RI	1
de Kok, T; Engels, L; Kleinjans, J	1
Breese, E; Del Soldato, P; Mitchell, J; Warner, T; Wood, E; Zacharowski, P	1
Alberti, PF; Del Soldato, P; Gresele, P; Minuz, P; Momi, S; Pitchford, SC	1
Bolla, M; Bronte, V; Colombo, MP; De Santo, C; Del Soldato, P; Dolcetti, L; Guiducci, C; Iezzi, M; Marigo, I; Melani, C; Musiani, P; Serafini, P; Zanovello, P	1
Corazzi, L; Corazzi, T; Gresele, P; Leone, M; Maucci, R	1
Burke, SG; Furman, BL; Vojnovic, I; Wainwright, CL; Warner, T; Watson, DG	1
Gao, J; Kashfi, K; Liu, X; Rigas, B	1
Ambrosini, MV; Covarelli, C; De Angelis, L; Del Soldato, P; Mariucci, G; Rambotti, MG; Tantucci, M	1
Bratasz, A; Ignarro, LJ; Kuppusamy, P; Parinandi, NL; Sridhar, R; Weir, NM; Zweier, JL	1
Cirino, G; Distrutti, E; Wallace, JL	1
Antonelli, E; Fiorucci, S	1
Amadori, D; Bolla, M; Brigliadori, G; Fabbri, F; Rosetti, M; Tesei, A; Ulivi, P; Vannini, I; Zoli, W	1
Cena, C; Fruttero, R; Gasco, A; Megson, IL; Rossi, AG; Turnbull, CM	1
Parthasarathy, S; Santanam, N	1
Kopelovich, L; Liu, X; Ouyang, N; Patlolla, JM; Rao, CV; Reddy, BS; Rigas, B; Simi, B; Steele, VE; Wang, CX	1
Darzynkiewicz, Z; Halicka, HD; Huang, X; Kurose, A; Tanaka, T; Traganos, F	1
Gresele, P; Momi, S	1
Antoniades, C; Stefanadis, C; Tousoulis, D	1
Beghi, C; Bonadonna, S; Corradi, D; De Cicco, G; Gherli, T; Giustina, A; Lorusso, R; Maestri, R; Mancini, T; Poli, E	1
Colantuono, G; Khan, M; Kumbala, D; Kuppusamy, P; Kutala, VK; Mandal, R; Potaraju, V	1
Bozzo, J; Khurdayan, VK; Moral, MA	1
Cooper, AJ; Dusse, LM; Lwaleed, BA	1
Mamuk, S; Melli, M	1
Kojda, G; Suvorava, T	1
Bonizzoni, E; De Monte, P; Gresele, P; Migliacci, R; Procacci, A	1
Hegde, KR; Varma, SD	1
Chen, WL; Fu, Y; Moore, PK; Wang, Z; Zhu, YZ	1
Ji, H; Peng, SX; Zhang, YH	1
Eubank, TD; Ignarro, LJ; Kaufman, BF; Kuppusamy, P; Kutala, VK; Marsh, CB; Parinandi, NL; Sharma, A	1
Angelini, GD; Jeremy, JY; Johnson, JL; Shukla, N; Wan, S; Yim, AP	1
Granger, DN; Specian, RD; Tailor, A; Wallace, JL; Wood, KC	1
Chandrasena, RE; Dunlap, T; Sinha, V; Thatcher, GR; Wang, Z	1
Bratasz, A; Ignarro, LJ; Kuppusamy, P; Selvendiran, K; Tong, L	1
Bobko, A; Bratasz, A; Ignarro, LJ; Khramtsov, VV; Kuppusamy, P; Selvendiran, K; Wasowicz, T	1
Bolla, M; Cormont, M; Gonzalez, T; Kaddai, V; Le Marchand-Brustel, Y	1
Ouyang, N; Rigas, B; Williams, JL	1
Brzozowski, T; Konturek, PC; Konturek, SJ; Pawlik, MW; Pawlik, WW; S Kwiecien, S; Sliwowski, Z	1
Bria, P; Di Gioia, A; Pomponi, M; Pomponi, MF	1
Balint, B; Bufan, B; Colić, M; Mojsilović, S; Vasilijić, S; Vucević, D; Vucićević, D	1
Butt, M; Lip, GY; Shantsila, E; Siddique, A	1
Chattopadhyay, M; Kashfi, K; Kogan, M; Nath, N; Vassell, R	1
Hua, A; Mackenzie, GG; Rigas, B	1
Bolli, GB; Giannini, S; Gresele, P; Guglielmini, G; Lucidi, P; Marzotti, S; Minuz, P; Momi, S	1
Cardona, F; Derhaschnig, U; Jilma, B; Marsik, C; Minuz, P; Schweeger-Exeli, I	1
Abdellatif, KR; Chattopadhyay, M; Kashfi, K; Keefer, LK; Nia, KV; Pruski, A; Velazquez, CA	1
Bolla, M; Daemen, MJ; Gijbels, MJ; Heeneman, S; Hoving, S; Pol, JF; Russell, NS; Simons, MY; Stewart, FA; te Poele, JA	1
Abdelrahman, AM; Farghaly, E; Gomaa, W; Ibrahim, M; Kelleni, M	1
Arosio, E; Bonizzoni, E; Gresele, P; Migliacci, R; Minuz, P; Violi, F	1
Janakiram, NB; Li, Q; Lightfoot, S; Mohammed, A; Rao, CV; Ritchie, RL; Steele, VE; Vibhudutta, A	1
Paranjpe, A; Srivenugopal, KS	1
Chattopadhyay, M; Kashfi, K; Kodela, R; Nath, N; Nazarenko, A; Rodes, DB	1
Güç, MO; Iskit, AB; Sökmensüer, C; Ulu, N	1
Delgadillo, D; Duarte, LF; Fernández-Ramires, R; Fernández-Soto, R; Jara, JA; Madariaga-Venegas, F; Molina-Berríos, A; Suarez, N; Urzúa, B	1
Aisa, MC; Datti, A; Di Renzo, GC; Orlacchio, A	1

Reviews

17 review(s) available for aspirin and nitroaspirin

Article	Year
NO-aspirins: a class of new anti-inflammatory and antithrombotic agents. Trends in pharmacological sciences, 1999, Volume: 20, Issue:8 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Fibrinolytic Agents; Gastric Mucosa; Humans; Inflammation; Mice; Platelet Activation; Rats	1999
[Nitic oxide and natriuretic peptides]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2000, Volume: 45, Issue:6 Suppl Topics: Adenylyl Cyclase Inhibitors; Aspirin; Cyclic GMP; Drug Design; Humans; Natriuretic Agents; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfhydryl Compounds; Sulfones	2000
Nitric oxide donors. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 225, Issue:3 Topics: Animals; Aspirin; Drug Tolerance; Heart; Humans; In Vitro Techniques; Molsidomine; Myocardial Infarction; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Superoxides; Triazenes	2000
NO-releasing NSAIDs are caspase inhibitors. Trends in immunology, 2001, Volume: 22, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caspase Inhibitors; Cytokines; Nitric Oxide; Nitrogen Oxides; Protein Processing, Post-Translational; Th1 Cells	2001
Potential cardioprotective actions of no-releasing aspirin. Nature reviews. Drug discovery, 2002, Volume: 1, Issue:5 Topics: Animals; Apoptosis; Arteriosclerosis; Aspirin; Caspase Inhibitors; Cell Adhesion; Cyclic GMP; Cytokines; Heart; Humans; Hypertension; Myocardial Infarction; Stroke	2002
Mandate to modify a medicinal mantra: maybe not yet? Gastroenterology, 2003, Volume: 124, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiotonic Agents; Cardiovascular System; Drug Administration Schedule; Humans; Peptic Ulcer	2003
NO-NSAIDs and cancer: promising novel agents. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2003, Volume: 35 Suppl 2 Topics: Animal Experimentation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Cell Line, Tumor; Humans; In Vitro Techniques; Naproxen; Nitric Oxide; Rats	2003
NCX-4016 NicOx. Current opinion in investigational drugs (London, England : 2000), 2003, Volume: 4, Issue:9 Topics: Animals; Aspirin; Cardiovascular Diseases; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Colonic Neoplasms; Cyclooxygenase Inhibitors; Humans; Molecular Structure; Nitric Oxide; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Structure-Activity Relationship	2003
Mechanisms of nonsteroidal anti-inflammatory drug-induced gastrointestinal injury and repair: a window of opportunity for cyclooxygenase-inhibiting nitric oxide donors. Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2004, Volume: 18, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gastrointestinal Diseases; Humans; Intestinal Mucosa; Isoenzymes; Membrane Proteins; Nitric Oxide Donors; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Stomach Ulcer; Sulfonamides	2004
Antiplatelet agents. The hematology journal : the official journal of the European Haematology Association, 2004, Volume: 5 Suppl 3 Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Design; Drug Resistance; Drug Therapy, Combination; Humans; Meta-Analysis as Topic; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Ticlopidine	2004
Nitric oxide and inflammation. Inflammation & allergy drug targets, 2006, Volume: 5, Issue:2 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Inflammation; Naproxen; Nitrates; Nitric Oxide	2006
NO-NSAIDs: from inflammatory mediators to clinical readouts. Inflammation & allergy drug targets, 2006, Volume: 5, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood Coagulation; Cardiovascular Diseases; Chemotaxis, Leukocyte; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Cytokines; Endothelial Cells; Gastrointestinal Tract; Gene Expression Regulation; Humans; Leukocytes; Macrophages; Mitochondria; Naproxen; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Platelet Aggregation	2006
Pharmacologic profile and therapeutic potential of NCX 4016, a nitric oxide-releasing aspirin, for cardiovascular disorders. Cardiovascular drug reviews, 2006,Summer, Volume: 24, Issue:2 Topics: Animals; Aspirin; Atherosclerosis; Endothelium, Vascular; Humans; Molecular Structure; Myocardial Ischemia; Nitric Oxide Donors; Platelet Aggregation Inhibitors; Treatment Outcome	2006
Chronicles in drug discovery. Drug news & perspectives, 2006, Volume: 19, Issue:8 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Budesonide; Cell Transformation, Neoplastic; Chemoprevention; Clinical Trials as Topic; Drug Evaluation, Preclinical; Glucocorticoids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neoplasms; Precancerous Conditions; Trypsin Inhibitor, Bowman-Birk Soybean; Trypsin Inhibitors	2006
Tissue factor and nitric oxide: a controversial relationship! Journal of thrombosis and thrombolysis, 2007, Volume: 23, Issue:2 Topics: Animals; Anticoagulants; Aspirin; Blood Coagulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitrates; Nitric Oxide; Pravastatin; Thromboplastin; Up-Regulation	2007
[A novel class of anti-inflammatory and analgesic drugs--NO-donating NSAIDs]. Yao xue xue bao = Acta pharmaceutica Sinica, 2007, Volume: 42, Issue:4 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiotonic Agents; Cyclooxygenase Inhibitors; Flurbiprofen; Gastrointestinal Diseases; Humans; Ibuprofen; Naproxen; Nitrates; Nitric Oxide Donors	2007
New antiplatelet drugs: beyond aspirin and clopidogrel. International journal of clinical practice, 2009, Volume: 63, Issue:5 Topics: Adenosine; Adenosine Monophosphate; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Drug Design; Humans; Imines; Lactones; Naphthalenes; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Propionates; Purinergic P2 Receptor Antagonists; Pyridines; Thiophenes; Ticagrelor; Ticlopidine	2009

Trials

9 trial(s) available for aspirin and nitroaspirin

Article	Year
Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study. Gastroenterology, 2003, Volume: 124, Issue:3 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiotonic Agents; Digestive System; Double-Blind Method; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Intestinal Mucosa; Male; Pilot Projects; Placebos; Platelet Aggregation; Thromboxane B2	2003
Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa. Proceedings of the National Academy of Sciences of the United States of America, 2003, Sep-16, Volume: 100, Issue:19 Topics: Adult; Aspirin; Celecoxib; Cyclooxygenase Inhibitors; Female; Gastric Mucosa; Humans; Isoenzymes; Lipoxins; Male; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides	2003
Chemiluminescence and LC-MS/MS analyses for the study of nitric oxide release and distribution following oral administration of nitroaspirin (NCX 4016) in healthy volunteers. Journal of pharmaceutical and biomedical analysis, 2004, Apr-16, Volume: 35, Issue:2 Topics: Administration, Oral; Adult; Aspirin; Chromatography, Liquid; Humans; Luminescent Measurements; Male; Mass Spectrometry; Nitric Oxide	2004
Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans. Journal of the American College of Cardiology, 2004, Aug-04, Volume: 44, Issue:3 Topics: Administration, Oral; Adult; Aspirin; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Duodenum; Flow Cytometry; Gastric Mucosa; Humans; Intestinal Mucosa; Male; Monocytes; Platelet Activation; Platelet Aggregation Inhibitors; Reference Values; Single-Blind Method; Stomach; Thromboxane A2; Thromboxane B2	2004
Functional effects of nitric oxide-releasing aspirin on vein conduits of diabetic patients undergoing CABG. International journal of cardiology, 2007, May-31, Volume: 118, Issue:2 Topics: Acetylcholine; Aged; Aspirin; Coronary Artery Bypass; Coronary Artery Disease; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Fibrinolytic Agents; Humans; Male; Nitroprusside; Saphenous Vein; Transplants; Vasoconstriction; Vasodilator Agents	2007
Prevention by NCX 4016, a nitric oxide-donating aspirin, but not by aspirin, of the acute endothelial dysfunction induced by exercise in patients with intermittent claudication. Thrombosis and haemostasis, 2007, Volume: 97, Issue:3 Topics: Aged; Aspirin; Blood Flow Velocity; Brachial Artery; Endothelium, Vascular; Exercise; Female; Humans; Intermittent Claudication; Leukocyte Count; Leukocyte Elastase; Lower Extremity; Male; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Platelet Aggregation Inhibitors; Prospective Studies; Reperfusion Injury; Severity of Illness Index; Single-Blind Method; Time Factors; Treatment Outcome; Vascular Cell Adhesion Molecule-1; Vasodilation	2007
Hyperglycemia-induced platelet activation in type 2 diabetes is resistant to aspirin but not to a nitric oxide-donating agent. Diabetes care, 2010, Volume: 33, Issue:6 Topics: Adolescent; Adult; Aged; Aspirin; Female; Flow Cytometry; Humans; Hyperglycemia; Male; Middle Aged; Nitric Oxide Donors; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Young Adult	2010
Effects of aspirin and NO-aspirin (NCX 4016) on platelet function and coagulation in human endotoxemia. Platelets, 2010, Volume: 21, Issue:5 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Coagulation; Blood Platelets; Double-Blind Method; Endotoxemia; Endotoxins; Humans; Male; Platelet Activation; Thromboxane B2; Young Adult	2010
Effect on walking distance and atherosclerosis progression of a nitric oxide-donating agent in intermittent claudication. Journal of vascular surgery, 2012, Volume: 56, Issue:6 Topics: Aged; Aspirin; Atherosclerosis; Carotid Intima-Media Thickness; Double-Blind Method; Drug Administration Schedule; Exercise Test; Exercise Tolerance; Female; Fibrinolytic Agents; Humans; Intermittent Claudication; Male; Middle Aged; Nitric Oxide Donors; Prospective Studies; Walking	2012

Other Studies

99 other study(ies) available for aspirin and nitroaspirin

Article	Year
Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin. Journal of medicinal chemistry, 2007, May-17, Volume: 50, Issue:10 Topics: Antineoplastic Agents; Apoptosis; Aspirin; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Indolequinones; Magnetic Resonance Spectroscopy; Nitric Oxide; Nitric Oxide Donors; Structure-Activity Relationship	2007
In vitro study of the anti-aggregating activity of two nitroderivatives of acetylsalicylic acid. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1996, Volume: 7, Issue:2 Topics: Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2; Thromboxane B2	1996
The antiplatelet effects of a new nitroderivative of acetylsalicylic acid--an in vitro study of inhibition on the early phase of platelet activation and on TXA2 production. Thrombosis and haemostasis, 1996, Volume: 76, Issue:5 Topics: Adult; Aspirin; Blood Platelets; Calcium; Cyclic GMP; Humans; P-Selectin; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thromboxane A2	1996
Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: role of neutrophils. The American journal of physiology, 1997, Volume: 273, Issue:6 Topics: Animals; Aspirin; Cell Adhesion; Gastric Mucosa; Male; Neutrophils; Nitric Oxide; Nitroglycerin; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Regional Blood Flow; Shock, Hemorrhagic	1997
Cyclooxygenase-independent chemoprevention with an aspirin derivative in a rat model of colonic adenocarcinoma. Life sciences, 1998, Volume: 62, Issue:23 Topics: Adenocarcinoma; Animals; Aspirin; Azoxymethane; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Isoenzymes; Male; Membrane Proteins; Mice; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid	1998
Effect of nitric oxide-releasing aspirin derivative on gastric functional and ulcerogenic responses in rats: comparison with plain aspirin. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1 Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Acid; Gastric Acidity Determination; Male; Nitric Oxide; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Stomach Ulcer	1998
In vivo antithrombotic effects of a nitric oxide-releasing aspirin derivative, NCX-4016. Thrombosis research, 1999, Jan-01, Volume: 93, Issue:1 Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibrinolytic Agents; Male; Nitric Oxide; Nitroprusside; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thromboxanes	1999
Cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal anti-inflammatory drugs and gastric mucosal responses. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1998, Volume: 49, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Cyclooxygenase 2; Dinoprostone; Edema; Ethanol; Gastric Mucosa; Gastrointestinal Contents; Hindlimb; Isoenzymes; Male; Nitrates; Nitric Oxide; Nitrites; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Stomach Diseases; Stomach Ulcer; Stress, Physiological; Wound Healing	1998
Nitric oxide-releasing NSAIDs inhibit interleukin-1beta converting enzyme-like cysteine proteases and protect endothelial cells from apoptosis induced by TNFalpha. Alimentary pharmacology & therapeutics, 1999, Volume: 13, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Caspase Inhibitors; Cell Line; Cysteine Proteinase Inhibitors; DNA Fragmentation; Endothelium, Vascular; Flurbiprofen; Gastric Mucosa; Humans; In Situ Nick-End Labeling; Male; Mice; Naproxen; Nitric Oxide; Peroxidase; Rats; Rats, Wistar	1999
Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats. Gastroenterology, 1999, Volume: 116, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Caspase Inhibitors; Caspases; Cyclic GMP; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Gastric Mucosa; Humans; In Situ Nick-End Labeling; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Rats; Salicylates; Time Factors; Tumor Necrosis Factor-alpha; U937 Cells	1999
NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokines. Gastroenterology, 2000, Volume: 118, Issue:2 Topics: Amino Acid Chloromethyl Ketones; Animals; Aspirin; Caspase 1; Caspase 3; Caspase Inhibitors; Caspases; Chemical and Drug Induced Liver Injury; Concanavalin A; Cysteine Proteinase Inhibitors; Cytokines; Fas Ligand Protein; fas Receptor; Interferon-gamma; Interleukin-18; Interleukins; Liver; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Platelet Aggregation Inhibitors; Receptors, Interleukin-2; RNA, Messenger; Spleen; T-Lymphocytes; Th1 Cells; Transcription, Genetic; Up-Regulation	2000
A comparison of the anti-inflammatory and anti-nociceptive activity of nitroaspirin and aspirin. British journal of pharmacology, 2000, Volume: 129, Issue:2 Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Edema; Formaldehyde; Hyperalgesia; Male; Mice; Pain Measurement; Rats; Rats, Wistar; Reaction Time	2000
Myocardial protection by the nitroderivative of aspirin, NCX 4016: in vitro and in vivo experiments in the rabbit. Italian heart journal : official journal of the Italian Federation of Cardiology, 2000, Volume: 1, Issue:2 Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Animals; Aspirin; Creatine Kinase; Dose-Response Relationship, Drug; Electrocardiography; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Peroxidase; Rabbits; Vasoconstrictor Agents; Ventricular Function, Left	2000
Prevention of pulmonary thromboembolism by NCX 4016, a nitric oxide-releasing aspirin. European journal of pharmacology, 2000, May-26, Volume: 397, Issue:1 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Lung; Male; Mice; Nitroarginine; Platelet Aggregation Inhibitors; Platelet Count; Pulmonary Artery; Pulmonary Embolism; Rabbits; Thrombin; Thrombosis	2000
A common pathway for nitric oxide release from NO-aspirin and glyceryl trinitrate. Biochemical and biophysical research communications, 2000, Jul-21, Volume: 274, Issue:1 Topics: Animals; Aspirin; Cell Line; Cyclic GMP; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Epithelial Cells; Free Radical Scavengers; Imidazoles; Kidney; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Protein Binding; Swine	2000
The effect of aspirin and two nitric oxide donors on the infarcted heart in situ. Life sciences, 2000, Jul-07, Volume: 67, Issue:7 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Cyclooxygenase Inhibitors; Drug Interactions; Enzyme Activation; Heart Rate; Male; Myocardial Infarction; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rabbits; Thromboxane A2; Triazenes; Ventricular Pressure	2000
Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in the stomach of diabetic rats. Life sciences, 2000, Aug-18, Volume: 67, Issue:13 Topics: Animals; Anti-Ulcer Agents; Aspirin; Diabetes Mellitus, Experimental; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Male; Nitric Oxide Donors; Nitro Compounds; Omeprazole; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Salicylic Acid; Stomach Diseases; Stomach Ulcer	2000
IL-1 beta converting enzyme is a target for nitric oxide-releasing aspirin: new insights in the antiinflammatory mechanism of nitric oxide-releasing nonsteroidal antiinflammatory drugs. Journal of immunology (Baltimore, Md. : 1950), 2000, Nov-01, Volume: 165, Issue:9 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caspase 1; Caspase Inhibitors; Cells, Cultured; Cysteine Proteinase Inhibitors; Cytokines; Enzyme Activation; Humans; Immunosuppressive Agents; Interleukin-1; Intracellular Fluid; Lipopolysaccharides; Macrophages; Monocytes; Nitric Oxide Donors; Nitroso Compounds	2000
Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice. Proceedings of the National Academy of Sciences of the United States of America, 2001, Feb-27, Volume: 98, Issue:5 Topics: Animals; Aspirin; Constriction, Pathologic; Hypercholesterolemia; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Receptors, LDL; Recurrence	2001
The nitroderivative of aspirin, NCX 4016, reduces infarct size caused by myocardial ischemia-reperfusion in the anesthetized rat. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Aspirin; Creatine Kinase; Cyclic GMP; Fibrinolytic Agents; Hemodynamics; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; NG-Nitroarginine Methyl Ester; Peroxidase; Platelet Aggregation Inhibitors; Rats; Rats, Wistar	2001
Nitro-aspirin (NCX4016) reduces brain damage induced by focal cerebral ischemia in the rat. Neuroscience letters, 2001, Apr-20, Volume: 302, Issue:2-3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Astrocytes; Brain; Brain Injuries; Brain Ischemia; Cell Survival; Functional Laterality; Glial Fibrillary Acidic Protein; HSP70 Heat-Shock Proteins; Immunohistochemistry; Immunosuppressive Agents; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Inbred SHR; Tacrolimus; Vimentin	2001
Effect of cyclooxygenase-2 inhibitor (celecoxib) on the infarcted heart in situ. Pharmacology, 2001, Volume: 63, Issue:1 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Epoprostenol; Heart; Isoenzymes; Male; Myocardial Infarction; Myocardium; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rabbits; Sulfonamides; Thromboxane A2	2001
Vasorelaxant effect of nitric oxide releasing steroidal and nonsteroidal anti-inflammatory drugs. British journal of pharmacology, 2001, Volume: 133, Issue:7 Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aspirin; Blood Pressure; Dose-Response Relationship, Drug; Flurbiprofen; In Vitro Techniques; Kidney; Male; Mesentery; Nitric Oxide; Nitroprusside; Prednisolone; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents	2001
Vasorelaxant effects of a nitric oxide-releasing aspirin derivative in normotensive and hypertensive rats. British journal of pharmacology, 2001, Volume: 133, Issue:8 Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aspirin; Blood Pressure; Consciousness; Dose-Response Relationship, Drug; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Nitroprusside; Phenylephrine; Rats; Rats, Wistar; Renin; Thromboxanes; Vasodilation	2001
Low gastric toxicity of nitric oxide-releasing aspirin, NCX-4016, in rats with cirrhosis and arthritis. Digestive diseases and sciences, 2001, Volume: 46, Issue:8 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Blood Flow Velocity; Gastric Acid; Gastric Mucosa; Hydrochloric Acid; Liver Cirrhosis; Male; Membrane Potentials; Nitric Oxide Donors; Nitro Compounds; Rats; Rats, Sprague-Dawley; Salicylates; Stomach Ulcer	2001
Nitrosylhemoglobin, an unequivocal index of nitric oxide release from nitroaspirin: in vitro and in vivo studies in the rat by ESR spectroscopy. Journal of pharmaceutical and biomedical analysis, 2001, Volume: 26, Issue:4 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Hemoglobins; Injections, Intraperitoneal; Male; Nitric Oxide; Rats; Rats, Wistar	2001
NCX4016 (NO-Aspirin) has multiple inhibitory effects in LPS-stimulated human monocytes. British journal of pharmacology, 2001, Volume: 134, Issue:4 Topics: Aspirin; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrinolytic Agents; Guanylate Cyclase; Humans; Interleukin-6; Lipopolysaccharides; Monocytes; Nitric Oxide; Oxadiazoles; Quinoxalines; Thromboplastin; Thromboxane B2; Tumor Necrosis Factor-alpha	2001
Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis. Proceedings of the National Academy of Sciences of the United States of America, 2002, Feb-05, Volume: 99, Issue:3 Topics: Aging; Angioplasty, Balloon, Coronary; Animals; Aspirin; Coronary Restenosis; Coronary Vessels; Disease Models, Animal; Fibrinolytic Agents; Hemoglobins; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Rats; Rats, Sprague-Dawley; Time Factors; Tunica Intima	2002
NCX4016 (NO-aspirin) reduces infarct size and suppresses arrhythmias following myocardial ischaemia/reperfusion in pigs. British journal of pharmacology, 2002, Volume: 135, Issue:8 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Aspirin; Coronary Disease; Endothelium, Vascular; Hemodynamics; Leukocytes; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Platelet Aggregation; Swine; Thromboxane B2; Ventricular Fibrillation	2002
Vascular protective actions of a nitric oxide aspirin analog in both in vitro and in vivo models of diabetes mellitus. Free radical biology & medicine, 2002, Jun-01, Volume: 32, Issue:11 Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Aspirin; Diabetes Mellitus, Experimental; Electron Spin Resonance Spectroscopy; Electrophoretic Mobility Shift Assay; Endothelium, Vascular; Free Radical Scavengers; Gene Expression; Glucose; Hydroxyl Radical; Hyperglycemia; Isoprostanes; Muscle Relaxation; Muscle, Smooth, Vascular; NF-kappa B; Nitric Oxide; Norepinephrine; Rats; Rats, Sprague-Dawley; Superoxides; Vasodilation	2002
In vitro metabolism of a nitroderivative of acetylsalicylic acid (NCX4016) by rat liver: LC and LC-MS studies. Journal of pharmaceutical and biomedical analysis, 2002, Aug-01, Volume: 29, Issue:6 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromatography, High Pressure Liquid; Cytosol; Glutathione Transferase; In Vitro Techniques; Inactivation, Metabolic; Male; Microsomes, Liver; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization	2002
NCX-4016, a nitric oxide-releasing aspirin, protects endothelial cells against apoptosis by modulating mitochondrial function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:12 Topics: Apoptosis; Aspirin; Cell Survival; Endothelium, Vascular; Humans; Microscopy, Confocal; Mitochondria; Nitric Oxide; Oxygen Consumption; Staurosporine; Time Factors	2002
NCX 4016, a nitric oxide-releasing aspirin, modulates adrenergic vasoconstriction in the perfused rat tail artery. British journal of pharmacology, 2002, Volume: 137, Issue:2 Topics: Animals; Arteries; Aspirin; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Male; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Perfusion; Rats; Rats, Wistar; Tail; Vasoconstriction	2002
Chronic treatment with nitric oxide-releasing aspirin reduces plasma low-density lipoprotein oxidation and oxidative stress, arterial oxidation-specific epitopes, and atherogenesis in hypercholesterolemic mice. Proceedings of the National Academy of Sciences of the United States of America, 2002, Sep-17, Volume: 99, Issue:19 Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Aspirin; Foam Cells; Hypercholesterolemia; Lipoproteins, LDL; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Donors; Oxidation-Reduction; Oxidative Stress; Receptors, LDL	2002
NCX-4016 (NO-aspirin) inhibits lipopolysaccharide-induced tissue factor expression in vivo: role of nitric oxide. Circulation, 2002, 12-10, Volume: 106, Issue:24 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cyclooxygenase 2; Cysteine Proteinase Inhibitors; Drug Administration Schedule; Flow Cytometry; Gastric Mucosa; Interleukin-1; Isoenzymes; Isosorbide Dinitrate; Male; Monocytes; Nitric Oxide; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thromboplastin; Thromboxane B2; Tumor Necrosis Factor-alpha	2002
Nitric oxide donating aspirins: novel drugs for the treatment of saphenous vein graft failure. The Annals of thoracic surgery, 2003, Volume: 75, Issue:5 Topics: Aged; Aspirin; Cell Division; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Middle Aged; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Platelet Aggregation Inhibitors; Saphenous Vein; Vasodilation	2003
NCX 4016, a nitric oxide-releasing aspirin derivative, exhibits a significant antiproliferative effect and alters cell cycle progression in human colon adenocarcinoma cell lines. International journal of oncology, 2003, Volume: 22, Issue:6 Topics: Adenocarcinoma; Anticarcinogenic Agents; Aspirin; Cell Cycle; Cell Division; Cell Survival; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Kinetics; Membrane Proteins; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Tumor Cells, Cultured	2003
Implications of reactive oxygen species and cytokines in gastroprotection against stress-induced gastric damage by nitric oxide releasing aspirin. International journal of colorectal disease, 2003, Volume: 18, Issue:4 Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Central Nervous System Depressants; Cytokines; Ethanol; Free Radical Scavengers; Gastric Mucosa; Glutathione Peroxidase; Immobilization; Ischemia; Lipid Peroxidation; Male; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Regional Blood Flow; Stress, Psychological; Superoxide Dismutase	2003
NO-aspirin: mechanism of action and gastrointestinal safety. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2003, Volume: 35 Suppl 2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Digestive System; Humans; Nitric Oxide; Platelet Aggregation; Regional Blood Flow	2003
NCX4016: a novel antithrombotic agent. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2003, Volume: 35 Suppl 2 Topics: Animals; Aspirin; Blood Platelets; Disease Models, Animal; Fibrinolytic Agents; Humans; In Vitro Techniques; Mice; Monocytes; Nitric Oxide; Platelet Aggregation Inhibitors; Pulmonary Embolism; Rabbits; Rats	2003
Anti-arthritic agents--SMi conference: trapping cytokines. 28-29 April 2003, London, UK. IDrugs : the investigational drugs journal, 2003, Volume: 6, Issue:6 Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Cytokines; Humans; Mitogen-Activated Protein Kinases; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Prednisolone; Pyrazoles	2003
Good news about gut-friendly aspirin. Harvard health letter, 2003, Volume: 28, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors	2003
Nitric oxide-releasing aspirin protects gastric mucosa against ethanol damage in rats with functional ablation of sensory nerves. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2003, Volume: 52, Issue:9 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Capsaicin; Ethanol; Gastric Mucosa; Glutathione Peroxidase; HSP70 Heat-Shock Proteins; Male; Nitric Oxide; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensory Receptor Cells; Stomach Ulcer; Superoxide Dismutase	2003
Nitric oxide-releasing aspirin inhibits vasoconstriction in perfused tail artery of normotensive and spontaneously hypertensive rats. European journal of pharmacology, 2003, Sep-05, Volume: 477, Issue:1 Topics: Animals; Arteries; Aspirin; Blood Pressure; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Nitrates; Nitric Oxide Donors; Nitrites; Perfusion; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tail; Thromboxane B2; Time Factors; Vasoconstriction	2003
Antioxidant activity of nitro derivative of aspirin against ischemia-reperfusion in hamster cheek pouch microcirculation. American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 286, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arterioles; Aspirin; Blood Pressure; Cricetinae; Erythrocytes; Heart Rate; Image Processing, Computer-Assisted; Leukocytes; Lipid Peroxides; Male; Mesocricetus; Microcirculation; Microscopy, Fluorescence; Mouth Mucosa; Nitric Oxide Donors; Nitro Compounds; Oxidative Stress; Receptors, Leukocyte-Adhesion; Regional Blood Flow; Reperfusion Injury	2004
Single oral dose study of two isosorbide-based aspirin prodrugs in the dog. The Journal of pharmacy and pharmacology, 2003, Volume: 55, Issue:10 Topics: Administration, Oral; Animals; Arachidonic Acid; Aspirin; Collagen; Dogs; Female; Isosorbide; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests	2003
Effect of nitric oxide-donating agents on human monocyte cyclooxygenase-2. Biochemical and biophysical research communications, 2003, Nov-28, Volume: 311, Issue:4 Topics: Aspirin; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Isoenzymes; Membrane Proteins; Monocytes; Nitric Oxide Donors; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases	2003
Aspirin, but not NO-releasing aspirin (NCX-4016), interacts with selective COX-2 inhibitors to aggravate gastric damage and inflammation. American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 286, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Gastric Mucosa; Gastritis; Isoenzymes; Lipoxins; Male; Neutropenia; Neutrophil Infiltration; Nitric Oxide; Peroxidase; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction	2004
No-Aspirin (NCX 4016). Gastroenterology, 2003, Volume: 125, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Digestive System; Endoscopy, Gastrointestinal; Humans; Nitric Oxide	2003
Cooperation between aspirin-triggered lipoxin and nitric oxide (NO) mediates antiadhesive properties of 2-(Acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester (NCX-4016) (NO-aspirin) on neutrophil-endothelial cell adherence. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Adhesion; Cells, Cultured; Drug Interactions; Endothelium, Vascular; Humans; Lipoxins; Neutrophils; Nitric Oxide	2004
Polymorphism of NCX4016, an NO-releasing derivative of acetylsalicylic acid. Journal of pharmaceutical sciences, 2004, Volume: 93, Issue:3 Topics: Aspirin; Nitric Oxide; X-Ray Diffraction	2004
Nitric oxide release and distribution following oral and intraperitoneal administration of nitroaspirin (NCX 4016) in the rat. Life sciences, 2004, May-14, Volume: 74, Issue:26 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromatography, High Pressure Liquid; Injections, Intraperitoneal; Male; Nitric Oxide; Rats; Rats, Wistar; Tissue Distribution	2004
The influence on human osteoblasts in vitro of non-steroidal anti-inflammatory drugs which act on different cyclooxygenase enzymes. The Journal of bone and joint surgery. British volume, 2004, Volume: 86, Issue:3 Topics: Acetaminophen; Alkaline Phosphatase; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Count; Cells, Cultured; Collagen; Cyclooxygenase Inhibitors; DNA; Flurbiprofen; Furans; Humans; Indomethacin; Nitrates; Nitric Oxide; Nitric Oxide Donors; Osteoblasts; Prostaglandin-Endoperoxide Synthases	2004
Nitric oxide regulates immune cell bioenergetic: a mechanism to understand immunomodulatory functions of nitric oxide-releasing anti-inflammatory drugs. Journal of immunology (Baltimore, Md. : 1950), 2004, Jul-15, Volume: 173, Issue:2 Topics: Adenosine Triphosphate; Adjuvants, Immunologic; Anti-Inflammatory Agents; Aspirin; Energy Metabolism; Glycolysis; Humans; Mitochondria; Nitric Oxide; T-Lymphocytes; Triazenes	2004
Nitroaspirins and morpholinosydnonimine but not aspirin inhibit the formation of superoxide and the expression of gp91phox induced by endotoxin and cytokines in pig pulmonary artery vascular smooth muscle cells and endothelial cells. Circulation, 2004, Aug-31, Volume: 110, Issue:9 Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Evaluation, Preclinical; Endothelial Cells; Endothelium, Vascular; Enzyme Induction; Epoprostenol; Glycoproteins; Guanylate Cyclase; Interleukin-1; Lipopolysaccharides; Male; Molsidomine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Onium Compounds; Pulmonary Artery; Respiratory Distress Syndrome; Superoxides; Sus scrofa; Tumor Necrosis Factor-alpha	2004
Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia. Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:11 Topics: Animals; Apoptosis; Aspirin; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Male; Mice; Mice, Inbred Strains; Muscle, Skeletal; Neovascularization, Physiologic; Nitric Oxide; Nitrites; Oxidative Stress; Reperfusion Injury; Vascular Endothelial Growth Factor A	2004
Theriac found? Nitric oxide-aspirin and the search for the universal cure. Journal of the American College of Cardiology, 2004, Aug-04, Volume: 44, Issue:3 Topics: Acetylation; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Design; Europe; History, 19th Century; History, 20th Century; History, Ancient; Humans; Neoplasms; Thrombosis	2004
Risk assessment of endogenous formation of carcinogenic N-nitroso compounds in response to intake of NO-aspirin. Gastroenterology, 2004, Volume: 127, Issue:3 Topics: Anti-Inflammatory Agents; Aspirin; Carcinogens; Humans; Nitroso Compounds; Risk Assessment	2004
NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives. European journal of pharmacology, 2005, Jan-31, Volume: 508, Issue:1-3 Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Flurbiprofen; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indomethacin; Membrane Proteins; Naproxen; Nitric Oxide Donors; Nitroprusside; Phosphodiesterase Inhibitors; Prostaglandin-Endoperoxide Synthases; Purinones; Synovial Membrane; Time Factors	2005
Nitroaspirin plus clopidogrel versus aspirin plus clopidogrel against platelet thromboembolism and intimal thickening in mice. Thrombosis and haemostasis, 2005, Volume: 93, Issue:3 Topics: Animals; Aspirin; Blood Coagulation Tests; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Hemorrhage; Male; Mice; Mice, Inbred Strains; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Survival Rate; Thromboembolism; Ticlopidine; Tunica Intima	2005
Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination. Proceedings of the National Academy of Sciences of the United States of America, 2005, Mar-15, Volume: 102, Issue:11 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cancer Vaccines; Carrier Proteins; Immune System Diseases; Lipocalins; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Neoplasms; Nitric Oxide Synthase; T-Lymphocytes; Time Factors	2005
Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016). The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:3 Topics: Animals; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dialysis; Dinoprostone; Dose-Response Relationship, Drug; Hemostatics; Humans; Kinetics; Molecular Structure; Monocytes; Platelet Aggregation Inhibitors; Sheep; Spectrophotometry; Thrombin; Thromboxane B2; Time Factors	2005
The effect of NCX4016 [2-acetoxy-benzoate 2-(2-nitroxymethyl)-phenyl ester] on the consequences of ischemia and reperfusion in the streptozotocin diabetic rat. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Pressure; Calcimycin; Diabetes Mellitus, Experimental; Heart Rate; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitric Oxide; Rats; Rats, Sprague-Dawley; Streptozocin	2006
NO-donating aspirin induces phase II enzymes in vitro and in vivo. Carcinogenesis, 2006, Volume: 27, Issue:4 Topics: Adenocarcinoma; Animals; Aspirin; Chemoprevention; Colonic Neoplasms; Enzyme Induction; Female; Glutathione Transferase; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Liver Neoplasms; Mice; Mice, Inbred C57BL; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Nitric Oxide; Proteins; Transplantation, Heterologous	2006
Ultrastructural investigations on protective effects of NCX 4016 (nitroaspirin) on macrovascular endothelium in diabetic Wistar rats. Journal of submicroscopic cytology and pathology, 2005, Volume: 37, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aspirin; Diabetes Mellitus, Experimental; Endothelium, Vascular; Male; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Rats; Rats, Wistar; Vascular Diseases	2005
Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin. Proceedings of the National Academy of Sciences of the United States of America, 2006, Mar-07, Volume: 103, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Electron Spin Resonance Spectroscopy; Female; Glutathione; Humans; Neoplasm Recurrence, Local; Nitric Oxide; Nitric Oxide Donors; Ovarian Neoplasms; Tumor Stem Cell Assay	2006
Molecular characterization of cytotoxic and resistance mechanisms induced by NCX 4040, a novel NO-NSAID, in pancreatic cancer cell lines. Apoptosis : an international journal on programmed cell death, 2006, Volume: 11, Issue:8 Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Caspase 9; Cell Cycle; Cell Line, Tumor; Cytotoxins; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Nitric Oxide Donors; Nitro Compounds; Pancreatic Neoplasms; S-Nitroso-N-Acetylpenicillamine; Salicylates	2006
Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets. British journal of pharmacology, 2006, Volume: 148, Issue:4 Topics: Adult; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Humans; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Platelet Aggregation; Salicylic Acid	2006
Aspirin is a substrate for paraoxonase-like activity: implications in atherosclerosis. Atherosclerosis, 2007, Volume: 191, Issue:2 Topics: Adult; Antioxidants; Aryldialkylphosphatase; Aspirin; Atherosclerosis; Binding, Competitive; Biotransformation; Humans; Hydrolysis; In Vitro Techniques; Nitrophenols; Paraoxon; Platelet Aggregation Inhibitors; Salicylic Acid	2007
Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets. Molecular cancer therapeutics, 2006, Volume: 5, Issue:6 Topics: Acetates; Animals; Antineoplastic Agents; Aspirin; Azoxymethane; beta Catenin; Carcinogens; Colonic Neoplasms; Cyclooxygenase 2; Diet; Dinoprostone; Humans; Indoles; Male; Nitric Oxide Synthase Type II; Rats; Rats, Inbred F344	2006
Nitrogen oxide-releasing aspirin induces histone H2AX phosphorylation, ATM activation and apoptosis preferentially in S-phase cells: involvement of reactive oxygen species. Cell cycle (Georgetown, Tex.), 2006, Volume: 5, Issue:15 Topics: Apoptosis; Aspirin; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Nucleus; Comet Assay; Cyclooxygenase Inhibitors; DNA-Binding Proteins; Histones; Humans; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Reactive Oxygen Species; S Phase; Tumor Cells, Cultured; Tumor Suppressor Proteins	2006
Nitric oxide-releasing aspirin: will it say NO to atherothrombosis? International journal of cardiology, 2007, May-31, Volume: 118, Issue:2 Topics: Aspirin; Coronary Thrombosis; Fibrinolytic Agents; Humans; Treatment Outcome	2007
Prevention of postischemic myocardial reperfusion injury by the combined treatment of NCX-4016 and Tempol. Journal of cardiovascular pharmacology, 2006, Volume: 48, Issue:3 Topics: Animals; Aspirin; Creatine Kinase; Cyclic N-Oxides; L-Lactate Dehydrogenase; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitric Oxide; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Spin Labels; Superoxide Dismutase; Superoxides; Uric Acid	2006
Effect of aspirin, paracetamol and their nitric oxide donating derivatives on exudate cytokine and PGE2 production in zymosan-induced air pouch inflammation in rats. European journal of pharmacology, 2007, Apr-30, Volume: 561, Issue:1-3 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinoprostone; Dose-Response Relationship, Drug; Female; Immunoenzyme Techniques; Inflammation; Interleukin-1beta; Neutrophils; Nitrates; Nitric Oxide Donors; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Zymosan	2007
Prevention of transient endothelial dysfunction in acute exercise: a friendly fire? Thrombosis and haemostasis, 2007, Volume: 97, Issue:3 Topics: Antioxidants; Aspirin; Endothelium, Vascular; Exercise; Humans; Intermittent Claudication; Lower Extremity; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Vasodilation	2007
Susceptibility of the ocular lens to nitric oxide: implications in cataractogenesis. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2007, Volume: 23, Issue:2 Topics: Adenosine Triphosphate; Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biological Transport; Cataract; Diabetes Complications; Free Radicals; Glutathione; Glutathione Disulfide; Lens, Crystalline; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Rubidium	2007
Cardioprotective effects of nitric oxide-aspirin in myocardial ischemia-reperfused rats. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Pressure; Cyclooxygenase 1; Cyclooxygenase 2; Enzyme Inhibitors; Heart Rate; Male; Myocardial Infarction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Ventricular Dysfunction, Left; Ventricular Function, Left	2007
Nitroaspirin (NCX-4016), an NO donor, is antiangiogenic through induction of loss of redox-dependent viability and cytoskeletal reorganization in endothelial cells. Antioxidants & redox signaling, 2007, Volume: 9, Issue:11 Topics: Animals; Antioxidants; Aspirin; Capillaries; Cattle; Cell Survival; Cells, Cultured; Cytoskeleton; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Humans; Hydrogen Peroxide; Lung; Microscopy, Fluorescence; Neovascularization, Physiologic; Nitric Oxide Donors; Oxidation-Reduction; Umbilical Veins	2007
Nitric oxide-donating aspirin (NCX 4016) inhibits neointimal thickening in a pig model of saphenous vein-carotid artery interposition grafting: a comparison with aspirin and morpholinosydnonimine (SIN-1). The Journal of thoracic and cardiovascular surgery, 2007, Volume: 134, Issue:4 Topics: Administration, Oral; Analysis of Variance; Anastomosis, Surgical; Animals; Aspirin; Carotid Arteries; Dose-Response Relationship, Drug; Graft Occlusion, Vascular; Male; Molsidomine; Nitric Oxide Donors; Saphenous Vein; Statistics, Nonparametric; Swine; Tunica Intima	2007
Roles of platelet and endothelial cell COX-1 in hypercholesterolemia-induced microvascular dysfunction. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:6 Topics: Animals; Aspirin; Blood Platelets; Bone Marrow Transplantation; Cardiovascular Diseases; Cell Adhesion; Chimera; Cholesterol, Dietary; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Hypercholesterolemia; Leukocytes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Microscopy, Video; Nitric Oxide Donors; Platelet Adhesiveness; Pyrazoles; Venules	2007
Quinone formation as a chemoprevention strategy for hybrid drugs: balancing cytotoxicity and cytoprotection. Chemical research in toxicology, 2007, Volume: 20, Issue:12 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoquinones; Catalysis; Cell Line, Tumor; Cell Survival; Chemoprevention; Cytoprotection; Esterases; Glutathione; Liver; Luciferases; Metabolic Detoxication, Phase II; Mice; Models, Biological; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; Nitro Compounds; Response Elements; Swine	2007
NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell cycle (Georgetown, Tex.), 2008, Jan-01, Volume: 7, Issue:1 Topics: Animals; Aspirin; Cell Line, Tumor; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; ErbB Receptors; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; STAT3 Transcription Factor; Transplantation, Heterologous	2008
NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols. Journal of translational medicine, 2008, Feb-26, Volume: 6 Topics: Animals; Antineoplastic Agents; Aspirin; Cell Line, Tumor; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Mice; Mice, Nude; Molecular Structure; Nitro Compounds; Ovarian Neoplasms; Sensitivity and Specificity; Statistics as Topic; Sulfhydryl Compounds; Xenograft Model Antitumor Assays	2008
The nitric oxide-donating derivative of acetylsalicylic acid, NCX 4016, stimulates glucose transport and glucose transporters translocation in 3T3-L1 adipocytes. American journal of physiology. Endocrinology and metabolism, 2008, Volume: 295, Issue:1 Topics: 3T3-L1 Cells; Adipocytes; Animals; Aspirin; Biological Transport; Blotting, Western; Cell Membrane; Deoxyglucose; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Immunohistochemistry; Mice; Microscopy, Fluorescence; Nitric Oxide Donors; Nitroprusside; Stimulation, Chemical	2008
NO-donating aspirin inhibits angiogenesis by suppressing VEGF expression in HT-29 human colon cancer mouse xenografts. Carcinogenesis, 2008, Volume: 29, Issue:9 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; HT29 Cells; Humans; Immunoenzyme Techniques; Male; Mice; Mice, Nude; Necrosis; Neovascularization, Pathologic; Nitric Oxide Donors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2008
Nitric oxide (NO)-releasing aspirin and (NO) donors in protection of gastric mucosa against stress. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2008, Volume: 59 Suppl 2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Immersion; Lipid Peroxidation; Male; Malondialdehyde; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Rats; Rats, Wistar; Reactive Oxygen Species; Regional Blood Flow; Restraint, Physical; S-Nitroso-N-Acetylpenicillamine; Stomach Ulcer; Stress, Psychological; Superoxide Dismutase	2008
Fatty aspirin: a new perspective in the prevention of dementia of Alzheimer's type? Current Alzheimer research, 2008, Volume: 5, Issue:5 Topics: Alzheimer Disease; Animals; Antioxidants; Aspirin; Cognition Disorders; Dementia; Disease Models, Animal; Docosahexaenoic Acids; Hippocampus; Memory; Mice; Microglia; Neurofibrillary Tangles; Neuronal Plasticity; Synapses	2008
Comparative effects of aspirin and NO-releasing aspirins on differentiation, maturation and function of human monocyte-derived dendritic cells in vitro. International immunopharmacology, 2009, Volume: 9, Issue:7-8 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, Differentiation; Apoptosis; Aspirin; Cell Differentiation; Cells, Cultured; Dendritic Cells; Down-Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-10; Interleukin-12 Subunit p40; Interleukin-4; Lipopolysaccharides; Lymphocyte Activation; Monocytes; Nitric Oxide; Nitro Compounds	2009
Nitro-aspirin inhibits MCF-7 breast cancer cell growth: effects on COX-2 expression and Wnt/beta-catenin/TCF-4 signaling. Biochemical pharmacology, 2009, Nov-15, Volume: 78, Issue:10 Topics: Anticarcinogenic Agents; Aspirin; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclooxygenase 2; DNA-Binding Proteins; Down-Regulation; Enzyme Induction; Female; Genes, Reporter; Humans; Inhibitory Concentration 50; Isomerism; Signal Transduction; Transcription Factor 4; Transcription Factors; Transcription, Genetic; Wnt Proteins	2009
The differential cell signaling effects of two positional isomers of the anticancer NO-donating aspirin. International journal of oncology, 2009, Volume: 35, Issue:4 Topics: Activating Transcription Factor 2; Antineoplastic Agents; Aspirin; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Enzyme Activation; HT29 Cells; Humans; Inhibitory Concentration 50; Isomerism; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Nitric Oxide Donors; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-jun; RNA Interference; Signal Transduction; Structure-Activity Relationship; Time Factors; Transcription Factor AP-1	2009
Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as safe anti-inflammatory, analgesic, antipyretic, antioxidant prodrugs. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Antipyretics; Aspirin; Dinoprostone; Disease Models, Animal; Edema; Fever; Gastric Mucosa; Hydrazines; Hyperalgesia; Lipid Peroxidation; Male; Malondialdehyde; Molecular Structure; Prodrugs; Rats; Rats, Wistar; Stomach Ulcer; Superoxide Dismutase; Tumor Necrosis Factor-alpha	2010
NO-donating aspirin and aspirin partially inhibit age-related atherosclerosis but not radiation-induced atherosclerosis in ApoE null mice. PloS one, 2010, Sep-21, Volume: 5, Issue:9 Topics: Age Factors; Animals; Apolipoproteins E; Aspirin; Atherosclerosis; Carotid Arteries; Disease Models, Animal; Down-Regulation; Female; Gene Expression; Humans; Intercellular Adhesion Molecule-1; Male; Mice; Mice, Inbred C57BL; Platelet Aggregation; Vascular Cell Adhesion Molecule-1; X-Rays	2010
Nitro-aspirin is a potential therapy for non alcoholic fatty liver disease. European journal of pharmacology, 2011, Jun-01, Volume: 659, Issue:2-3 Topics: Alanine Transaminase; Animals; Aspirin; Cyclooxygenase 2; Fatty Liver; Gene Expression Regulation, Enzymologic; Liver; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Triglycerides	2011
Inhibition of pancreatic intraepithelial neoplasia progression to carcinoma by nitric oxide-releasing aspirin in p48(Cre/+)-LSL-Kras(G12D/+) mice. Neoplasia (New York, N.Y.), 2012, Volume: 14, Issue:9 Topics: Animals; Anticarcinogenic Agents; Aspirin; beta Catenin; Body Weight; Carcinoma in Situ; Carcinoma, Pancreatic Ductal; Cell Transformation, Neoplastic; Cyclin D1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Progression; Humans; Integrases; Male; Mice; Mice, Transgenic; Nitric Oxide Synthase Type II; Pancreatic Neoplasms; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins p21(ras); Tumor Suppressor Protein p53	2012
Degradation of NF-κB, p53 and other regulatory redox-sensitive proteins by thiol-conjugating and -nitrosylating drugs in human tumor cells. Carcinogenesis, 2013, Volume: 34, Issue:5 Topics: Animals; Antineoplastic Agents; Aspirin; Cell Line, Tumor; Disulfiram; DNA-Binding Proteins; HCT116 Cells; HT29 Cells; Humans; Liver; Male; Mice; NF-kappa B; Oxidation-Reduction; Proteasome Endopeptidase Complex; Rabbits; Reticulocytes; Tumor Suppressor Protein p53; Ubiquitin-Activating Enzymes	2013
Nitric Oxide-Releasing Aspirin Suppresses NF-κB Signaling in Estrogen Receptor Negative Breast Cancer Cells in Vitro and in Vivo. Molecules (Basel, Switzerland), 2015, Jul-09, Volume: 20, Issue:7 Topics: Animals; Antineoplastic Agents; Apoptosis; Aspirin; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Inhibitory Concentration 50; Injections, Subcutaneous; Luciferases; Mice; Mice, Nude; NF-kappa B; Proliferating Cell Nuclear Antigen; Reactive Oxygen Species; Receptor, ErbB-2; Receptors, Estrogen; Signal Transduction; Xenograft Model Antitumor Assays	2015
The effects of aspirin, flurbiprofen, and NO-donating acetylsalicylic acid (NCX 4016) on mice models of endotoxic and septic shock. Turkish journal of medical sciences, 2015, Volume: 45, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Disease Models, Animal; Flurbiprofen; Liver; Male; Mice; Shock, Septic; Spleen; Treatment Outcome	2015
Characterization of a novel antibiofilm effect of nitric oxide-releasing aspirin (NCX-4040) on Candida albicans isolates from denture stomatitis patients. PloS one, 2017, Volume: 12, Issue:5 Topics: Antifungal Agents; Aspirin; Bacterial Adhesion; Biofilms; Candida albicans; Dinoprostone; Drug Resistance, Fungal; Fluconazole; Free Radical Scavengers; Humans; Inhibitory Concentration 50; Microbial Viability; Nitro Compounds; Stomatitis, Denture	2017
COX inhibitors and bone: A safer impact on osteoblasts by NO-releasing NSAIDs. Life sciences, 2018, Sep-01, Volume: 208 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bone Neoplasms; Cathepsin B; Cell Differentiation; Cell Proliferation; Cyclooxygenase 2 Inhibitors; Humans; Metalloproteases; Naproxen; Nitric Oxide; Osteoblasts; Osteosarcoma; Plasminogen Activators; Tumor Cells, Cultured	2018