aspirin and misoprostol

aspirin has been researched along with misoprostol in 78 studies

Research

Studies (78)

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (20.51)	18.7374
1990's	19 (24.36)	18.2507
2000's	25 (32.05)	29.6817
2010's	17 (21.79)	24.3611
2020's	1 (1.28)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Abramson, SB; Kitsis, EA; Weissmann, G	1
Broen, JJ; Cafruny, WA; DesJarlais, SE; Hecht, ML; Jaqua, RA	1
Bergmann, JF; Caulin, C; Naudin, R; Segrestaa, JM; Simoneau, G	1
Albrecht, M; Brandt, KD; O'Bryan-Tear, G	1
Deysach, LG; Geis, GS; Kochman, RL; Lanza, FL; Rack, EM	1
Schubert, ML	1
Blueml, G; Dajani, EZ; Lewin, J; Reimann, HJ; Schmidt, U; Wendt, P	1
Jiranek, GC; Kimmey, MB; Saunders, DR; Shanahan, W; Silverstein, FE; Willson, RA	1
Agrawal, N; Crager, M; Mahowald, M; Miller, S; Montoya, H; Nissen, C; Nutting, E; Robbins, D; Roth, S; Woods, E	1
Kimmey, MB; Levine, DS; Saunders, DR; Silverstein, FE	1
Bauer, RF; Bianchi, RG; Casler, J; Goldstin, B	1
Dammann, HG; Müller, P; Simon, B	2
Kimmey, MB; Saunders, DR; Silverman, BA; Silverstein, FE; Surawicz, CM; Willson, RA	1
Clay, GA; McMahon, FG; Ryan, JR; Vargas, R	1
Anglin, CP; Bauer, RF; Dajani, EZ; Gullikson, GW; Kessler, LK; Smeach, S	1
Laudanno, OM	1
Dickson, B; Gustitus, L; Lanza, F; Peace, K; Rack, MF	1
Gana, TJ; Koo, J; MacPherson, BR	1
Armstrong, L; Clark, L; Cohen, MM; D'Souza, J	1
Dajani, EZ; Nissen, CH	1
Davis, EK; Jensen, JC; Jensen, NF; Larsen, KR; Moody, FG	1
Andrews, FJ; Malcontenti-Wilson, C; O'Brien, PE	1
Lee, M	1
Bianchi, RG; Casler, JJ; Collins, PW; Fenton, RL; Kowalski, DL; McGrath, MP; Perkins, WE; Stolzenbach, JC; Tremont, SJ; Wagner, GM	1
Andrews, FJ; O'Brien, PE; Penney, AG	1
Dizbay-Sak, S; Melli, M; Saray, A; Taşcilar, O	1
Boudrieau, RJ; Labato, MA; Matz, ME; Murtaugh, RJ	1
Ferraz, P; Geraldo, J; Wallace, JL	1
Cmiel, A; Mastalerz, L; Nizankowska, E; Szczeklik, A	1
Szmidt, M; Wasiak, W	2
Guslandi, M	1
Anastassiades, T; Chopra, R; Law, C; Wong, E	1
Bishop, A; Crome, R; Duggan, AE; Filipowicz, B; Hawkey, CJ; Hull, M; Knifton, A; Polak, J; Stack, W; Weber, C	1
Donnelly, MT; Filipowicz, B; Goddard, AF; Hawkey, CJ; Morant, SV; Shield, MJ	1
Sung, JJ	1
Lanas, AI	1
Scheiman, JM	1
McCarthy, DM	1
Fernández-Fernández, FJ	1
Bienkiewicz, B; DuBuske, L; Kowalski, ML; Pawliczak, R; Ptasinska, A	1
Andriulli, A; D'Ambrosio, LP; Di Mario, F; Franceschi, M; Leandro, G; Longo, MG; Niro, V; Paris, F; Pilotto, A	1
Chan, FK; Graham, DY	1
Kotaira, J	1
Laine, L	1
Amer, F; Christopoulos, NG; Goldstein, JL; Huang, B	1
Berta, GN; Cesano, L; Corvetti, G; Di Carlo, F; Ghezzo, F; Mognetti, B; Pesce, E; Pirro, E; Zingaro, B	1
Chan, FK	1
Gavazzi, A; Invernizzi, P; Lucà, MG; Rossini, R; Scuri, P; Strazzabosco, M	1
Ferrandez, A; Lanas, A	1
Bayan, K; Canoruç, F; Daniş, R; Dursun, M; Ertem, M; Kilinç, N; Tüzün, Y; Yilmaz, S	1
Bienkiewicz, B; Jedrzejczak-Czechowicz, M; Kowalski, ML; Lewandowska-Polak, A	1
Bobb, A; Bulsiewicz, W; Christensen, K; Coté, GA; Howden, CW; Norvell, JP; Postelnick, M; Rice, JP	1
Arakawa, T; Fujiwara, Y; Higuchi, K; Kameda, N; Machida, H; Okazaki, H; Oshitani, N; Sugimori, S; Tanigawa, T; Tominaga, K; Watanabe, K; Watanabe, T	1
Lanas, A; Nardulli, G	1
Chan, FK; Lanza, FL; Quigley, EM	1
Adachi, A; Fujiwara, N; Fukumoto, T; Inoue, Y; Kohno, K; Matsuo, H; Morita, E; Nishitani, N; Ueno, M	1
Jeon, SW; Kim, JW; Lee, JH; Lee, SW; Lee, YC	1
Kaithwas, G; Majumdar, DK	1
Ikeda, M; Kohno, K; Morita, E; Nakajima, K; Sano, S; Takahashi, A	1
Jankowski, A; Jarzebska, M; Jedrzejczak-Czechowicz, M; Kowalski, ML; Lewandowska-Polak, A; Makowska, JS	1
Chan, FK; Ho, CW; Mulder, CJ; Tse, YK; Wu, B	1
Howden, CW	1
Chan, FK; Ho, CW	1
Amagase, K; Satoh, H; Takeuchi, K	1
Hamura, K; Matsuo, H; Yokooji, T	1
Baldelli, F; Cipriani, S; D'Amore, C; Distrutti, E; Fiorucci, S; Francisci, D; Mencarelli, A; Renga, B; Santucci, L	1
Blandizzi, C; Corona, T; Cristofano, M; Montagnani, S; Salvadori, S; Scarpignato, C; Testi, A; Tuccori, M	1
Simon, RA; Walters, KM; White, AA; Wineinger, NE; Woessner, KM	1
Rockall, TA	1
McCloskey, C; McConnachie, A; McSkimming, P; Taha, AS	1
Arakawa, T; Chan, FKL; Cheong, PK; Ching, JYL; Fujiwara, Y; Higashimori, A; Kee, KM; Kyaw, MH; Lam, K; Lee, V; Otani, K; Suen, BY; Tanigawa, T; Tse, YK; Watanabe, T	1
Beales, ILP	1
Chan, FKL; Fujiwara, Y; Watanabe, T	1

Reviews

10 review(s) available for aspirin and misoprostol

Article	Year
Prevention and treatment of nonsteroidal anti-inflammatory drug-induced gastropathy. Southern medical journal, 1995, Volume: 88, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Gastric Mucosa; Histamine H2 Antagonists; Humans; Misoprostol; Peptic Ulcer; Ranitidine; Risk Factors	1995
Management of nonsteroidal anti-inflammatory drug-related peptic ulcer bleeding. The American journal of medicine, 2001, Jan-08, Volume: 110, Issue:1A Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Butanones; Helicobacter Infections; Helicobacter pylori; Humans; Misoprostol; Nabumetone; Peptic Ulcer Hemorrhage; Secondary Prevention	2001
The impact of nonsteroidal anti-inflammatory drug-induced gastropathy. The American journal of managed care, 2001, Volume: 7, Issue:1 Suppl Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Dyspepsia; Histamine H2 Antagonists; Humans; Misoprostol; Peptic Ulcer; Ranitidine	2001
Prevention and treatment of gastrointestinal symptoms and complications due to NSAIDs. Best practice & research. Clinical gastroenterology, 2001, Volume: 15, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Gastrointestinal Diseases; Histamine H2 Antagonists; Humans; Misoprostol; Omeprazole; Risk Factors; Sucralfate	2001
Review article: prevention of non-steroidal anti-inflammatory drug gastrointestinal complications--review and recommendations based on risk assessment. Alimentary pharmacology & therapeutics, 2004, May-15, Volume: 19, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cyclooxygenase 2; Decision Making; Gastrointestinal Diseases; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; Isoenzymes; Membrane Proteins; Misoprostol; Prostaglandin-Endoperoxide Synthases; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Stomach Ulcer	2004
Proton pump inhibitor co-therapy with nonsteroidal anti-inflammatory drugs--nice or necessary? Reviews in gastroenterological disorders, 2004, Volume: 4 Suppl 4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Humans; Misoprostol; Proton Pump Inhibitors; Risk Factors; Stomach Ulcer	2004
NSAID-induced peptic ulcers and Helicobacter pylori infection: implications for patient management. Drug safety, 2005, Volume: 28, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apoptosis; Aspirin; Gastric Acid; Gastritis; Helicobacter pylori; Humans; Misoprostol; Peptic Ulcer; Prostaglandins	2005
NSAID-induced gastrointestinal damage: current clinical management and recommendations for prevention. Chinese journal of digestive diseases, 2006, Volume: 7, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2 Inhibitors; Drug Combinations; Dyspepsia; Evidence-Based Medicine; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Middle Aged; Misoprostol; Proton Pump Inhibitors	2006
[Risk of gastrointestinal bleeding with aspirin and platelet antiaggregants]. Gastroenterologia y hepatologia, 2009, Volume: 32, Issue:1 Topics: Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dinoprostone; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; Middle Aged; Misoprostol; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Thromboxanes; Ticlopidine	2009
Current knowledge on non-steroidal anti-inflammatory drug-induced small-bowel damage: a comprehensive review. Journal of gastroenterology, 2020, Volume: 55, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Capsule Endoscopy; Gastrointestinal Hemorrhage; Humans; Intestinal Diseases; Intestine, Small; Misoprostol; Peptic Ulcer	2020

Trials

24 trial(s) available for aspirin and misoprostol

Article	Year
[Protective effect of misoprostol on the changes of transgastric potential difference induced by aspirin in man]. Revue du rhumatisme et des maladies osteo-articulaires, 1991, Volume: 58, Issue:2 Topics: Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Double-Blind Method; Female; Gastric Mucosa; Humans; Male; Membrane Potentials; Misoprostol	1991
A double-blind, placebo-controlled, 6-day evaluation of two doses of misoprostol in gastroduodenal mucosal protection against damage from aspirin and effect on bowel habits. The American journal of gastroenterology, 1991, Volume: 86, Issue:12 Topics: Adult; Aspirin; Diarrhea; Double-Blind Method; Duodenal Diseases; Duodenoscopy; Female; Gastric Mucosa; Gastroscopy; Humans; Intestinal Mucosa; Male; Middle Aged; Misoprostol; Stomach Diseases	1991
Treatment of NSAID-induced gastroduodenal ulcers. Gastroenterology, 1990, Volume: 99, Issue:5 Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Aspirin; Humans; Misoprostol; Peptic Ulcer	1990
Misoprostol reduces gastroduodenal injury from one week of aspirin: an endoscopic study. Gastroenterology, 1989, Volume: 96, Issue:2 Pt 2 Sup Topics: Adolescent; Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Gastroscopy; Humans; Male; Misoprostol; Random Allocation; Stomach Ulcer	1989
Misoprostol heals gastroduodenal injury in patients with rheumatoid arthritis receiving aspirin. Archives of internal medicine, 1989, Volume: 149, Issue:4 Topics: Adult; Aged; Alprostadil; Anti-Ulcer Agents; Arthritis, Rheumatoid; Aspirin; Double-Blind Method; Duodenoscopy; Female; Gastroscopy; Humans; Male; Middle Aged; Misoprostol; Multicenter Studies as Topic; Peptic Ulcer; Random Allocation	1989
Gastric protection by misoprostol against 1300 mg of aspirin. An endoscopic study. Digestive diseases and sciences, 1986, Volume: 31, Issue:2 Suppl Topics: Adolescent; Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Clinical Trials as Topic; Double-Blind Method; Gastric Acid; Gastric Mucosa; Gastroscopy; Humans; Misoprostol	1986
[Acute injury to the gastric mucosa by acetylsalicylic acid. A comparative endoscopic study in man with oral prostaglandin analogs, omeprazole and ranitidine]. Arzneimittel-Forschung, 1986, Volume: 36, Issue:2 Topics: Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Clinical Trials as Topic; Double-Blind Method; Gastric Mucosa; Gastroscopy; Humans; Misoprostol; Omeprazole; Prostaglandins E; Prostaglandins, Synthetic; Random Allocation; Ranitidine; Rioprostil; Stomach Ulcer	1986
Gastric protection by misoprostol against 1,300 mg of aspirin. An endoscopic dose-response study. The American journal of medicine, 1987, Jul-27, Volume: 83, Issue:1A Topics: Adolescent; Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Dose-Response Relationship, Drug; Gastric Mucosa; Gastroscopy; Humans; Male; Misoprostol	1987
Role of misoprostol in reducing aspirin-induced gastrointestinal blood loss in arthritic patients. The American journal of medicine, 1987, Jul-27, Volume: 83, Issue:1A Topics: Alprostadil; Anti-Ulcer Agents; Aspirin; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Misoprostol; Osteoarthritis	1987
A blinded endoscopic comparative study of misoprostol versus sucralfate and placebo in the prevention of aspirin-induced gastric and duodenal ulceration. The American journal of gastroenterology, 1988, Volume: 83, Issue:2 Topics: Alprostadil; Anti-Ulcer Agents; Aspirin; Duodenoscopy; Duodenum; Gastric Mucosa; Gastroscopy; Humans; Intestinal Mucosa; Misoprostol; Peptic Ulcer; Random Allocation; Sucralfate	1988
[Stomach tolerance of nonsteroidal antirheumatic drugs: comparative endoscopic study]. Zeitschrift fur Rheumatologie, 1987, Volume: 46 Suppl 1 Topics: Adult; Alprostadil; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Gastroscopy; Humans; Indomethacin; Misoprostol; Omeprazole; Prostaglandins E; Ranitidine; Rioprostil; Stomach Ulcer	1987
Reduction of aspirin-induced fecal blood loss with low-dose misoprostol tablets in man. Digestive diseases and sciences, 1985, Volume: 30, Issue:7 Topics: Adult; Aspirin; Chromium Radioisotopes; Double-Blind Method; Drug Evaluation; Feces; Gastrointestinal Hemorrhage; Humans; Male; Misoprostol; Prostaglandins E, Synthetic; Random Allocation	1985
Gastrointestinal cytoprotective effects of misoprostol. Clinical efficacy overview. Digestive diseases and sciences, 1985, Volume: 30, Issue:11 Suppl Topics: Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Bile Acids and Salts; DNA; Drug Evaluation; Duodenum; Ethanol; Feces; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Intestinal Mucosa; Male; Membrane Potentials; Misoprostol	1985
Use of synthetic prostaglandin E1 (misoprostol) for prevention of aspirin-induced gastroduodenal ulceration in arthritic dogs. Journal of the American Veterinary Medical Association, 1993, Jan-15, Volume: 202, Issue:2 Topics: Animals; Aspirin; Diarrhea; Dog Diseases; Dogs; Double-Blind Method; Duodenoscopy; Female; Gastrointestinal Hemorrhage; Gastroscopy; Male; Misoprostol; Osteoarthritis; Peptic Ulcer; Vomiting	1993
Protective and bronchodilator effects of prostaglandin E and salbutamol in aspirin-induced asthma. American journal of respiratory and critical care medicine, 1996, Volume: 153, Issue:2 Topics: Administration, Inhalation; Administration, Oral; Adult; Albuterol; Alprostadil; Aspirin; Asthma; Bronchi; Bronchodilator Agents; Dinoprostone; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Misoprostol; Prostaglandins E	1996
Protection against aspirin-induced human gastric mucosal injury by bosentan, a new endothelin-1 receptor antagonist. Alimentary pharmacology & therapeutics, 1999, Volume: 13, Issue:5 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bosentan; Cross-Over Studies; Dinoprostone; Double-Blind Method; Endothelin Receptor Antagonists; Gastric Mucosa; Humans; Male; Misoprostol; Receptor, Endothelin A; Sulfonamides	1999
A six week double blind, placebo controlled, crossover study of the effect of misoprostol in the treatment of aspirin sensitive asthma. Thorax, 1999, Volume: 54, Issue:10 Topics: Adult; Aged; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cross-Over Studies; Dinoprostone; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Misoprostol; Peak Expiratory Flow Rate; Prostaglandins E	1999
Low-dose misoprostol for the prevention of low-dose aspirin-induced gastroduodenal injury. Alimentary pharmacology & therapeutics, 2000, Volume: 14, Issue:5 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Double-Blind Method; Duodenal Ulcer; Gastric Mucosa; Humans; Misoprostol; Stomach Ulcer	2000
[Prospective comparative study on protective effect of the proton pump inhibitor and the prostaglandin analog on H. pylori-negative gastric mucosa of healthy subjects against low-dose aspirin]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 2004, Volume: 79, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Enzyme Inhibitors; Female; Gastric Mucosa; Gastroscopy; Humans; Male; Misoprostol; Omeprazole; Prospective Studies; Proton Pump Inhibitors; Rabeprazole; Stomach Ulcer	2004
Ulcer recurrence in high-risk patients receiving nonsteroidalanti-inflammatory drugs plus low-dose aspirin: results of a post HOC subanalysis. Clinical therapeutics, 2004, Volume: 26, Issue:10 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Duodenal Ulcer; Female; Humans; Lansoprazole; Male; Middle Aged; Misoprostol; Omeprazole; Peptic Ulcer Hemorrhage; Prospective Studies; Proton Pump Inhibitors; Risk Factors; Secondary Prevention; Stomach Ulcer; Treatment Outcome	2004
Does adding misoprostol to standard intravenous proton pump inhibitor protocol improve the outcome of aspirin/NSAID-induced upper gastrointestinal bleeding?: a randomized prospective study. Digestive diseases and sciences, 2007, Volume: 52, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Comorbidity; Drug Therapy, Combination; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Misoprostol; Omeprazole; Pantoprazole; Pilot Projects; Prospective Studies; Recurrence	2007
Small bowel injury by low-dose enteric-coated aspirin and treatment with misoprostol: a pilot study. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2008, Volume: 6, Issue:11 Topics: Aged; Anti-Ulcer Agents; Aspirin; Capsule Endoscopy; Female; Humans; Intestine, Small; Male; Middle Aged; Misoprostol; Pilot Projects; Prospective Studies; Tablets, Enteric-Coated; Treatment Outcome; Ulcer	2008
Misoprostol for small bowel ulcers in patients with obscure bleeding taking aspirin and non-steroidal anti-inflammatory drugs (MASTERS): a randomised, double-blind, placebo-controlled, phase 3 trial. The lancet. Gastroenterology & hepatology, 2018, Volume: 3, Issue:7 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Capsule Endoscopy; Double-Blind Method; Duodenal Ulcer; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Misoprostol; Peptic Ulcer Hemorrhage; Stomach Ulcer	2018
Misoprostol Heals Small Bowel Ulcers in Aspirin Users With Small Bowel Bleeding. Gastroenterology, 2018, Volume: 155, Issue:4 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Biomarkers; Capsule Endoscopy; Double-Blind Method; Female; Hemoglobins; Hong Kong; Humans; Intestine, Small; Japan; Male; Middle Aged; Misoprostol; Peptic Ulcer Hemorrhage; Prospective Studies; Time Factors; Treatment Outcome; Wound Healing	2018

Other Studies

44 other study(ies) available for aspirin and misoprostol

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
The prostaglandin paradox: additive inhibition of neutrophil function by aspirin-like drugs and the prostaglandin E1 analog misoprostol. The Journal of rheumatology, 1991, Volume: 18, Issue:10 Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcimycin; Calcium; Cell Aggregation; Cyclic AMP; Depression, Chemical; Drug Synergism; Glucuronidase; Humans; Indomethacin; Misoprostol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Prostaglandins; Sodium Salicylate; Superoxides; Tetradecanoylphorbol Acetate	1991
Enhancement of murine susceptibility to oral lactate dehydrogenase-elevating virus infection by non-steroidal anti-inflammatory agents, and antagonism by misoprostol. Antiviral research, 1991, Volume: 15, Issue:1 Topics: Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Aspirin; Diclofenac; Female; Indomethacin; Lactate dehydrogenase-elevating virus; Mice; Mice, Inbred Strains; Misoprostol; Virus Diseases	1991
Misoprostol does not protect articular cartilage from salicylate-induced suppression of proteoglycan synthesis. Journal of clinical pharmacology, 1991, Volume: 31, Issue:7 Topics: Alprostadil; Animals; Aspirin; Cartilage, Articular; Cells, Cultured; Culture Media; Dogs; Glycosaminoglycans; Humerus; Misoprostol; Salicylates; Salicylic Acid; Sodium Salicylate	1991
Misoprostol prevents damage to the gastric mucosa by stabilizing the mast cells. Prostaglandins, 1987, Volume: 33 Suppl Topics: Alprostadil; Animals; Anti-Ulcer Agents; Aspirin; Ethanol; Gastric Mucosa; Guinea Pigs; Histamine; Histamine Release; Male; Mast Cells; Misoprostol; Stomach Ulcer; Stress, Psychological	1987
Comparative mucosal protective properties of misoprostol, cimetidine, and sucralfate. Digestive diseases and sciences, 1986, Volume: 31, Issue:2 Suppl Topics: Alprostadil; Aluminum; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Ethanol; Gastric Mucosa; Indomethacin; Male; Misoprostol; Rats; Stress, Physiological; Sucralfate; Taurocholic Acid	1986
Misoprostol attenuates aspirin-induced changes in potential difference and associated damage in canine gastric mucosa. Clinical and investigative medicine. Medecine clinique et experimentale, 1987, Volume: 10, Issue:3 Topics: Alprostadil; Animals; Anti-Ulcer Agents; Aspirin; DNA; Dogs; Dose-Response Relationship, Drug; Epithelium; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Membrane Potentials; Misoprostol; Potassium; Stomach Ulcer	1987
Cytoprotective effect of S-adenosylmethionine compared with that of misoprostol against ethanol-, aspirin-, and stress-induced gastric damage. The American journal of medicine, 1987, Nov-20, Volume: 83, Issue:5A Topics: Alprostadil; Animals; Anti-Ulcer Agents; Aspirin; Ethanol; Gastric Mucosa; Gastritis; Intestinal Mucosa; Male; Misoprostol; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Stress, Physiological; Sulfhydryl Compounds	1987
Gastric mucosal blood flow in misoprostol pretreated aspirin-induced ulceration. Annals of surgery, 1988, Volume: 207, Issue:3 Topics: Alprostadil; Animals; Anti-Ulcer Agents; Aspirin; Dogs; Female; Gastric Mucosa; Male; Misoprostol; Research Design; Stomach Ulcer	1988
The cytoprotective effects of (+/-)-15-deoxy-16-alpha, beta-hydroxy-16-methyl PGE1 methyl ester (sc-29333) versus aspirin-shock gastric ulcerogenesis in the dog. Prostaglandins, 1981, Volume: 21 Suppl Topics: Animals; Aspirin; Dogs; Gastric Mucosa; Misoprostol; Prostaglandins E, Synthetic; Shock, Hemorrhagic; Stomach Ulcer	1981
Effect of nonsteroidal anti-inflammatory drugs on LFA-1 and ICAM-1 expression in gastric mucosa. The American journal of physiology, 1994, Volume: 266, Issue:4 Pt 1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Adhesion Molecules; Gastric Mucosa; Immunohistochemistry; Indomethacin; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Male; Misoprostol; Rats; Rats, Inbred Strains; Staining and Labeling	1994
Polymer delivery of the active isomer of misoprostol: a solution to the intestinal side effect problem. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:1 Topics: Animals; Antacids; Aspirin; Biological Availability; Butadienes; Depression, Chemical; Diarrhea; Dogs; Drug Carriers; Ethanol; Female; Gastric Mucosa; Hypromellose Derivatives; Indomethacin; Intestinal Diseases; Male; Methylcellulose; Misoprostol; Polymers; Rats; Rats, Inbred Strains; Stomach Diseases	1994
Effects of misoprostol on delayed ulcer healing induced by aspirin. Digestive diseases and sciences, 1994, Volume: 39, Issue:5 Topics: Acetates; Acetic Acid; Animals; Aspirin; Gastric Mucosa; Male; Misoprostol; Rats; Rats, Inbred Strains; Stomach Ulcer	1994
Acetylsalicylic acid and misoprostol combination in adjuvant arthritis of rats. Inflammation, 1993, Volume: 17, Issue:4 Topics: Animals; Arthritis, Experimental; Aspirin; Dose-Response Relationship, Drug; Drug Combinations; Female; Foot; Joints; Male; Misoprostol; Rats; Tail	1993
Prostaglandins modulate the responsiveness of the gastric microcirculation of sodium nitroprusside in cirrhotic rats. Hepatology (Baltimore, Md.), 1996, Volume: 23, Issue:1 Topics: Analysis of Variance; Animals; Arginine; Aspirin; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Indomethacin; Liver Cirrhosis, Experimental; Male; Microcirculation; Misoprostol; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Prostaglandins; Rats; Rats, Sprague-Dawley; Stomach; Vasodilator Agents	1996
[The influence of misoprostol on post-aspirin bronchoconstriction in patients with aspirin sensitive asthma]. Pneumonologia i alergologia polska, 1995, Volume: 63, Issue:9-10 Topics: Adult; Aspirin; Asthma; Bronchoconstriction; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Misoprostol	1995
Gastric safety and enteric-coated aspirin. Lancet (London, England), 1997, Feb-08, Volume: 349, Issue:9049 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Buffers; Gastrointestinal Hemorrhage; Humans; Misoprostol; Tablets, Enteric-Coated	1997
In vitro suppression of transforming growth factor-beta induced stimulation of glycosaminoglycan synthesis by acetylsalicylic acid and its reversal by misoprostol. The Journal of rheumatology, 1998, Volume: 25, Issue:10 Topics: Animals; Aspirin; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Glycosaminoglycans; Insulin-Like Growth Factor I; Misoprostol; Transforming Growth Factor beta	1998
Current approaches to reducing gastrointestinal toxicity of low-dose aspirin. The American journal of medicine, 2001, Jan-08, Volume: 110, Issue:1A Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Lansoprazole; Misoprostol; Omeprazole; Peptic Ulcer; Ranitidine	2001
Might proton pump inhibitors prevent the antiplatelet effects of low- or very low-dose aspirin? Archives of internal medicine, 2002, Oct-28, Volume: 162, Issue:19 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Biological Availability; Humans; Misoprostol; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Stomach Ulcer	2002
Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. The Journal of allergy and clinical immunology, 2003, Volume: 112, Issue:3 Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Dinoprostone; Drug Tolerance; Eicosanoids; Female; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Ionophores; Leukocytes; Leukotriene C4; Lipoxins; Male; Middle Aged; Misoprostol	2003
The risk of upper gastrointestinal bleeding in elderly users of aspirin and other non-steroidal anti-inflammatory drugs: the role of gastroprotective drugs. Aging clinical and experimental research, 2003, Volume: 15, Issue:6 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Administration Schedule; Female; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Humans; Male; Misoprostol; Proton Pump Inhibitors; Risk Assessment	2003
Salicylate inhibition of rat mammary carcinogenesis and angiogenesis in female rat compatible with misoprostol administration. International journal of oncology, 2005, Volume: 26, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Transformation, Neoplastic; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Mammary Neoplasms, Animal; Misoprostol; Neovascularization, Pathologic; Oxytocics; Rats; Rats, Sprague-Dawley; Salicylic Acid	2005
[Antiplatelet drugs and gastrointestinal bleeding: numquam periclum sine periclo vincitur]. Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology, 2005, Volume: 6, Issue:10 Topics: Age Factors; Aged; Aged, 80 and over; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Gastric Mucosa; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Meta-Analysis as Topic; Middle Aged; Misoprostol; Peptic Ulcer; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Risk Factors	2005
Involvement of 15-lipoxygenase and prostaglandin EP receptors in aspirin-triggered 15-hydroxyeicosatetraenoic acid generation in aspirin-sensitive asthmatics. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2008, Volume: 38, Issue:7 Topics: Adolescent; Adult; Aged; Arachidonate 15-Lipoxygenase; Aspirin; Asthma; Caffeic Acids; Dinoprostone; Drug Hypersensitivity; Female; Humans; Hydroxyeicosatetraenoic Acids; Leukocytes; Lipoxygenase Inhibitors; Male; Middle Aged; Misoprostol; Receptors, Prostaglandin E	2008
Use of physician education and computer alert to improve targeted use of gastroprotection among NSAID users. The American journal of gastroenterology, 2008, Volume: 103, Issue:5 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiology; Coronary Care Units; Female; Gastroenterology; Humans; Inservice Training; Internship and Residency; Male; Medical Order Entry Systems; Medical Records Systems, Computerized; Middle Aged; Misoprostol; Omeprazole; Patient Discharge; Peptic Ulcer Hemorrhage; Proton Pump Inhibitors; Risk Factors; Software; Telemetry	2008
Guidelines for prevention of NSAID-related ulcer complications. The American journal of gastroenterology, 2009, Volume: 104, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Anticoagulants; Aspirin; Cyclooxygenase 2 Inhibitors; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; Misoprostol; Peptic Ulcer; Peptic Ulcer Hemorrhage; Proton Pump Inhibitors; Risk Factors	2009
[The inhibition effect of a synthetic analogue of prostaglandin E1 to the provocation by aspirin in the patients of WDEIA]. Arerugi = [Allergy], 2009, Volume: 58, Issue:10 Topics: Adult; Alprostadil; Anaphylaxis; Aspirin; Exercise; Female; Gliadin; Humans; Middle Aged; Misoprostol; Premedication; Wheat Hypersensitivity	2009
[Guidelines of prevention and treatment for NSAID-related peptic ulcers]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2009, Volume: 54, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Anticoagulants; Aspirin; Cyclooxygenase 2 Inhibitors; Helicobacter Infections; Helicobacter pylori; Humans; Misoprostol; Peptic Ulcer; Proton Pump Inhibitors	2009
Primary prevention of ulcers in patients taking aspirin or NSAIDs. The Medical letter on drugs and therapeutics, 2010, Mar-08, Volume: 52, Issue:1333 Topics: Antacids; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Histamine H2 Antagonists; Humans; Misoprostol; Peptic Ulcer; Proton Pump Inhibitors	2010
Evaluation of antiulcer and antisecretory potential of Linum usitatissimum fixed oil and possible mechanism of action. Inflammopharmacology, 2010, Volume: 18, Issue:3 Topics: Acetylcholine; Animals; Aspirin; Atropine; Cholinergic Antagonists; Cimetidine; Ethanol; Flax; Gastric Mucosa; Guinea Pigs; Histamine; Histamine H1 Antagonists; Hydrogen-Ion Concentration; Ileum; Indomethacin; Ligation; Linseed Oil; Misoprostol; Muscle Contraction; Promethazine; Pylorus; Rats; Rats, Wistar; Reserpine; Serotonin; Stomach Ulcer; Stress, Psychological	2010
Pre-treatment with misoprostol prevents food-dependent exercise-induced anaphylaxis (FDEIA). International journal of dermatology, 2011, Volume: 50, Issue:2 Topics: Anaphylaxis; Anti-Asthmatic Agents; Aspirin; Bread; Cromolyn Sodium; Drug Therapy, Combination; Exercise; Food Hypersensitivity; Gliadin; Humans; Male; Middle Aged; Misoprostol	2011
Lack of association between aspirin-triggered 15-hydroxyeicosatetraenoic acid release and mast cell/eosinophil activation in nasal polyps from aspirin-sensitive patients. Journal of investigational allergology & clinical immunology, 2011, Volume: 21, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Arachidonate 15-Lipoxygenase; Aspirin; Calcium Ionophores; Drug Hypersensitivity; Eosinophils; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Mast Cells; Middle Aged; Misoprostol; Nasal Polyps	2011
The use of prophylactic gastroprotective therapy in patients with nonsteroidal anti-inflammatory drug- and aspirin-associated ulcer bleeding: a cross-sectional study. Alimentary pharmacology & therapeutics, 2013, Volume: 37, Issue:8 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cross-Sectional Studies; Drug Utilization; Female; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male; Medication Adherence; Middle Aged; Misoprostol; Patient Compliance; Proton Pump Inhibitors; Receptors, Histamine H2; Stomach Ulcer	2013
Commentary: improving the use of gastroprotective agents among high-risk NSAID users. Alimentary pharmacology & therapeutics, 2013, Volume: 37, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Gastrointestinal Hemorrhage; Humans; Male; Misoprostol; Proton Pump Inhibitors; Receptors, Histamine H2	2013
Commentary: improving the use of gastroprotective agents among high-risk NSAID users--authors' reply. Alimentary pharmacology & therapeutics, 2013, Volume: 37, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Gastrointestinal Hemorrhage; Humans; Male; Misoprostol; Proton Pump Inhibitors; Receptors, Histamine H2	2013
The role of food for the formation and prevention of gastrointestinal lesions induced by aspirin in cats. Digestive diseases and sciences, 2013, Volume: 58, Issue:10 Topics: Administration, Oral; Animals; Aspirin; Cats; Cimetidine; Diet; Dietary Fiber; Disease Models, Animal; Eating; Female; Intestines; Male; Misoprostol; Peptic Ulcer; Stomach; Tablets, Enteric-Coated	2013
Intestinal absorption of lysozyme, an egg-white allergen, in rats: kinetics and effect of NSAIDs. Biochemical and biophysical research communications, 2013, Aug-16, Volume: 438, Issue:1 Topics: Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Drug Interactions; Egg Proteins; Intestinal Absorption; Male; Metabolic Clearance Rate; Misoprostol; Muramidase; Rats; Rats, Sprague-Dawley	2013
In vivo administration of ritonavir worsens intestinal damage caused by cyclooxygease inhibitors. European journal of pharmacology, 2014, Jan-15, Volume: 723 Topics: Alprostadil; Animals; Apoptosis; Aspirin; Chemokine CCL2; Cyclooxygenase Inhibitors; Dinoprostone; Drug Synergism; HIV Protease Inhibitors; HT29 Cells; Humans; Integrin alpha1beta1; Intestinal Mucosa; Intestine, Small; Ketoprofen; Mice; Mice, Inbred C57BL; Misoprostol; Naproxen; Nitric Oxide Synthase Type II; Ritonavir; RNA, Messenger; Tumor Necrosis Factor-alpha	2014
Adherence with regulatory resolutions on prevention of NSAIDS-related gastrointestinal injury in Italy. International journal of clinical pharmacy, 2016, Volume: 38, Issue:4 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Utilization; Female; Gastrointestinal Diseases; Guideline Adherence; Humans; Italy; Male; Middle Aged; Misoprostol; Proton Pump Inhibitors; Retrospective Studies; Time Factors	2016
Effect of misoprostol on patients with aspirin-exacerbated respiratory disease undergoing aspirin challenge and desensitization. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2017, Volume: 119, Issue:1 Topics: Adolescent; Adult; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Desensitization, Immunologic; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Misoprostol; Respiratory Function Tests; Respiratory Hypersensitivity; Severity of Illness Index; Treatment Outcome; Young Adult	2017
Misoprostol for NSAID-induced small bowel erosions and ulcers. The lancet. Gastroenterology & hepatology, 2018, Volume: 3, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Double-Blind Method; Humans; Misoprostol; Ulcer	2018
Misoprostol for Aspirin-Induced Small Bowel Enteropathy: A Small Step in the Right Direction. Gastroenterology, 2018, Volume: 155, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Humans; Intestinal Diseases; Intestine, Small; Misoprostol	2018