aspirin has been researched along with arachidonic acid in 785 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 281 (35.80) | 18.7374 |
| 1990's | 186 (23.69) | 18.2507 |
| 2000's | 166 (21.15) | 29.6817 |
| 2010's | 122 (15.54) | 24.3611 |
| 2020's | 30 (3.82) | 2.80 |
| Authors | Studies |
|---|---|
| Bohlin, L; Danielson, H; Noreen, Y; Perera, P; Ringbom, T | 1 |
| Bohlin, L; Huss, U; Perera, P; Ringbom, T; Vasänge, M | 1 |
| Bhatti, R; Kaur, M; Sharma, S; Singh, A; Singh, P | 1 |
| Cha, CJ; Clowes, GH; Henry, WL; Salomon, JC | 1 |
| Carpy, A; Devaux, G; Montagut, M; Nuhrich, A; Varache-Beranger, M | 1 |
| Augustyn, OP; Botha, A; Coetzee, DJ; Kock, JL; Truscott, M; van Dyk, MS | 1 |
| Davis, BB; Jacob, AK; Reznikoff, CA; Thomas, DJ; Zenser, TV | 1 |
| Christiansen, SC; Juergens, UR; Stevenson, DD; Zuraw, BL | 1 |
| Abe, M; Shigematsu, N; Tanaka, K | 1 |
| Carroll, RC; Rubinstein, E; Urso, I | 1 |
| Diss, EM; Gabbe, SG; Kniss, DA; Moore, JW | 1 |
| Colgan, SP; Grauer, GF; Rose, BJ; Thrall, MA; Toolan, L | 1 |
| Simmet, T; Tschorn, K; Weide, I | 1 |
| Reynolds, EC; West, VC; Wong, A | 1 |
| Adil, Q; Begum, S; Gilani, AH; Shaheen, F; Siddiqui, BS; Siddiqui, S | 1 |
| Ardlie, NG; Bartlett, MR; McGuiness, JA; Selley, ML | 1 |
| Giessler, C; Heinroth-Hoffmann, I; Mest, HJ | 1 |
| Cheung, DT; Cobble, S; Nimni, ME; Schonfeld, SE; Yazdi, M | 1 |
| Misso, NL; Stewart, GA; Taylor, ML; Thompson, PJ | 2 |
| Arm, JP; Christie, PE; Lee, TH; Smith, C | 1 |
| Engels, W; Kleinjans, JC; Schilderman, PA; Schutte, B; Ten Hoor, F; Wenders, JJ | 1 |
| Imai, S; Ino, T; Mitsuoka, Y; Momo, K; Nakamura, K; Ohkubo, H; Someya, K; Tachiiri, T | 1 |
| Bezian, JH; Cabanieu, G; Gualde, N; Guez, S | 1 |
| Broughton Pipkin, F; Fox, S; Heptinstall, S; Louden, KA; Mitchell, JR; O'Callaghan, C; Symonds, EM; Tuohy, P | 1 |
| de la Cruz, JP; Mata, JM; Sanchez de la Cuesta, F | 1 |
| Ambrosio, G; Chiariello, M; Golino, P; Pascucci, I; Ragni, M; Russolillo, E | 1 |
| Bochkov, VN; Prokazova, NV; Tkachuk, VA; Vasylevskaya, VV | 1 |
| Grimminger, F; Seeger, W; Sibelius, U | 1 |
| Teng, CM; Wang, JP | 1 |
| Amerini, S; Ledda, F; Mantelli, L | 1 |
| Davis, BB; Jacob, AK; Thomas, DJ; Zenser, TV | 1 |
| Cesar, JM; Fernandez-Rivas, M; Losada, E | 1 |
| Chang, WC; Huang, JD; Lin, MT; Ning, CC | 1 |
| Arm, JP; Christie, PE; Lee, TH; Smith, CM | 1 |
| Anderson, CA; Antonello, JM; Clark, RL; Vetter, CM; Wise, LD | 1 |
| Inoue, M; Kanemaru, Y; Kazama, Y; Noguchi, T; Onaya, T; Tawata, M; Wakasugi, M | 1 |
| Bernard, H; Boisseau, M; Casadebaig, F; Daret, D; Dupin, JP; Gravier, D; Hou, G; Larrue, J | 1 |
| Inoue, M; Iwane, Y; Kobune, K; Kudo, T; Morikawa, M; Takanami, Y; Tsuboi, M | 1 |
| Borgeat, P; Odeimat, A; Poubelle, PE | 1 |
| Cass, WA; Fitzpatrick, FA; Larson, G; Zahniser, NR | 1 |
| Mase, K; Yasunaga, K | 1 |
| Kumegawa, M; Kusaka, M; Oshima, T; Takai, T; Tanabe, T; Yamamoto, S; Yokoyama, C; Yoshimoto, T | 1 |
| Becherucci, C; Mugridge, KG; Parente, L; Perretti, M | 1 |
| Takahashi, O | 1 |
| Augustyn, OP; Coetzee, DJ; Kock, JL; Nigam, S; van Dyk, MS | 1 |
| Bonorris, GG; Marks, JW; Schoenfield, LJ | 1 |
| Chan, AC; Chow, CK; Ganz, PR; Raynor, T; Tran, K | 1 |
| Bonavita, MS; Ghiselli, A; Iuliano, L; Praticò, D; Violi, F | 1 |
| Cullaré, C; de Castellarnau, C; de Moragas, JM; Puig, L; Solá, J; Vila, L | 1 |
| Cattaneo, M; Lecchi, A; Mannucci, PM; Tenconi, PM | 1 |
| Huang, ZS; Lee, TK | 1 |
| Barkai, G; Mashiach, S; Schiff, E | 1 |
| Force, T; Hibberd, P; Leaf, A; Lorenz, R; Milani, R; Uedelhoven, W; Weber, P | 1 |
| Galettis, P; Norton, RS | 1 |
| Burch, JW; Burch, PT | 1 |
| Dujovne, CA; Harris, WS; Silveira, S | 1 |
| Pinto, A; Sorrentino, L; Sorrentino, R | 1 |
| Hakenkamp, K; Ryan, WL; Sullivan, E | 1 |
| Beetens, J; De Clerck, F; Janssen, PA; Loots, W; Somers, Y; Wouters, L; Wynants, J | 1 |
| Castagna, M; Da Silva, C; Fan, XT; Huang, XP | 1 |
| Szczeklik, A | 2 |
| Frans, A; Garin, PR | 1 |
| Higashihara, M; Kariya, T; Kume, S; Matsumoto, Y; Ozaki, Y; Yatomi, Y | 1 |
| Gergely, H; Hollander, D; Stachura, J; Tarnawski, A | 1 |
| Braun, M; Schrör, K | 1 |
| Alonso, MT; Garcia-Sancho, J; Sanchez, A | 1 |
| Biagi, G; Dell'Omodarme, G; Giorgi, I; Livi, O; Scartoni, V | 1 |
| Akagi, T; Inoue, O; Kato, H; Sato, N | 1 |
| Edwards, J; Hawgood, BJ; Smith, IC | 1 |
| Biagi, G; Dell'Omodarme, G; Ferretti, M; Giorgi, I; Livi, O; Scartoni, V; Tiscione, E | 1 |
| Rao, GH; White, JG | 4 |
| Borgeat, P; Fournier, M; Hebert, J; Pelletier, G; Salari, H | 1 |
| Voigtländer, V | 1 |
| Goetzl, EJ; Payan, DG; Valacer, DJ; Wong, MY | 1 |
| Hamano, S; Ikeda, S; Kojima, M; Komatsu, H; Kusama, H; Nakazawa, M; Tsutsumi, N; Ujiie, A | 1 |
| Disa, J; Kowalska, MA; Rao, AK | 1 |
| Kadowitz, PJ; Mayeux, PR; McNamara, DB | 1 |
| Barradas, MA; Dandona, P; Hoffbrand, AV; Jeremy, JY; Kontoghiorghes, GJ; Mikhailidis, DP | 1 |
| Barriga, C; De la Fuente, M; Rodriguez, AB | 1 |
| Peskar, BA; Sinzinger, H; Virgolini, I | 1 |
| Fujii, Y; Sakurai, J | 1 |
| Anderson, LA; Dunford, HB; Graff, G; MacDonald, ID | 1 |
| Palma-Carlos, AG; Palma-Carlos, ML; Santos, MC | 1 |
| Abboud, FM; Axtelle, TS; Chapleau, MW; McDowell, TS | 1 |
| Aizawa, Y; Miyajima, S; Shibata, A | 1 |
| Bleifeld, W; Kupper, W; Schuster, O; Terres, W | 1 |
| Axelrod, L; Lane, J; Parker, J | 1 |
| Inoguchi, T; Kunisaki, M; Nawata, H; Ono, H; Umeda, F; Watanabe, J | 1 |
| Kumazawa, T; Maeda, N; Tomoda, K; Tsuji, H; Yamashita, T | 1 |
| Chap, H; Douste-Blazy, L; Hullin, F; Pascal, M; Ragab-Thomas, JM; Sepulchre, C | 1 |
| Bienkowski, MJ; Gorman, RR; Lin, AH | 1 |
| Mortensen, ME; Rennebohm, RM | 1 |
| Chakraborti, S; Gurtner, GH; Michael, JR | 1 |
| Arosio, E; Guzzo, P; Lechi, A; Lechi, C; Minuz, P; Paluani, F; Sinigaglia, D | 1 |
| Ailhaud, G; Gaillard, D; Négrel, R | 1 |
| Bauer, JA; Conzen, P; Fritz, H; Wurster, K | 1 |
| Gentry, PA; Liptrap, RM; Niemuller, C; Ross, ML | 1 |
| Altomare, GF; Pigatto, PD; Polenghi, MM; Tadini, GL; Villa, S | 1 |
| ElAttar, TM; Lin, HS; Platt, RD | 1 |
| de Faire, U; Hamsten, A; Svensson, J; Szamosi, A; Walldius, G | 1 |
| Gelman, JS; Mehta, J | 1 |
| Cannizzaro, S; Davì, G; Giubilato, A; Strano, A | 1 |
| Holman, RT | 1 |
| Hammerschmidt, DE; Husak, M; Jacob, HS; Jeanneret, C; Lobell, M | 1 |
| Barzaghi, G; Cerletti, C; de Gaetano, G | 1 |
| Dworski, R; Gajewski, P; Nizankowska, E; Szczeklik, A | 1 |
| Arnout, J; Deckmyn, H; Gresele, P; Huybrechts, E; Pieters, G; Vermylen, J | 1 |
| Bailey, JM; Pash, JM | 1 |
| Pillsbury, HC; Poole, MD | 1 |
| Housholder, GT | 1 |
| Hashimoto, Y; Kato, H; Kawamura, M; Kume, S; Naito, C; Oka, H; Teramoto, T; Watanabe, T | 1 |
| Hashimoto, Y; Kato, H; Kawamura, M; Naito, C; Oka, H; Teramoto, T | 1 |
| de Gaetano, G; Lorico, A; Masturzo, P; Salmona, M; Semeraro, N; Villa, S | 1 |
| Evans, PM; Lanham, DF | 1 |
| Maridonneau-Parini, I; Tauber, AI; Tringale, SM | 1 |
| Hassid, A | 1 |
| Bucchi, F; Cerletti, C; de Gaetano, G | 1 |
| Banga, HS; Brass, LF; Rittenhouse, SE; Simons, ER | 1 |
| Bailey, JM | 1 |
| Boyd, MR; Lau, SS; McMahon, JB; McMenamin, MG; Schuller, HM | 1 |
| Ciabattoni, G; Cominelli, F; Gentilini, P; La Villa, G; Laffi, G; Mannelli, M; Patrignani, P; Pinzani, M | 1 |
| Brash, AR; Ingram, CD; Maas, RL | 1 |
| Kinlough-Rathbone, RL; Mustard, JF; Winocour, PD | 1 |
| Benigni, A; Bertani, T; Carminati, C; Cutillo, F; Morelli, C; Remuzzi, G; Rocchi, G; Verroust, P | 1 |
| Emms, H; Lewis, GP | 1 |
| de Wahl, K; Malmgren, R; Theorell, H; Unge, G; Zetterström, O | 1 |
| Fischer, C; Frölich, JC; Meese, CO; Rosenkranz, B | 1 |
| Carroll, RC; Cox, AC | 1 |
| Bernard, H; Boisseau, MR; Casadebaig, F; Dupin, JP; Gravier, D | 1 |
| Goldman, AS; Gupta, C | 1 |
| Band, V; Farooq, A; Kharbanda, SM; Murugesan, K | 1 |
| Bellido, I; Camara, S; de la Cruz, JP; Martos, F; Sanchez de la Cuesta, F | 1 |
| Ishikawa, S; Manabe, S; Wada, O | 1 |
| Finiasz, M; Gimeno, M; Lazzari, MA; Schattner, MA | 2 |
| Broekman, MJ; Lorenzet, R; Marcus, AJ; Niemetz, J | 1 |
| Ghai, R; Lindsay, LA; Olson, RW; Sakane, Y; Smith, EF | 1 |
| Cerbone, AM; DiMinno, G; Murphy, S; Silver, MJ | 1 |
| Malmgren, R | 1 |
| Kimura, Y; Nakase, H; Watanabe, K | 1 |
| Boukili, MA; Bureau, M; Lagente, V; Lefort, J; Lellouch-Tubiana, A; Malanchère, E; Vargaftig, BB | 1 |
| Wallace, JL; Whittle, BJ | 1 |
| Paul, ML; Philp, RB | 1 |
| Beving, H; Kristensson, J; Malmgren, R; Olsson, U; Schmidt, S; Svensson, J | 1 |
| Frölich, JC; Küster, LJ | 1 |
| Holmsen, H | 1 |
| Adkinson, NF; Brown, MS; Kagey-Sobotka, A; Lichtenstein, LM; Naclerio, RM; Norman, PS; Peters, SP; Proud, D | 1 |
| Aono, J; Nabata, H; Sakai, K | 1 |
| Asai, F; Matsuda, K; Ushiyama, S; Yamazaki, M | 1 |
| Peskar, BA | 1 |
| Bomalaski, JS; Clark, MA; Conway, TM; Crooke, ST; Wartell, J | 1 |
| Cook, JA; Halushka, PV; Smith, EF; Wise, WC | 1 |
| Niebyl, JR; Witter, FR | 1 |
| Bernard, C; Escoubet, B; Ferrary, E; Sterkers, O | 1 |
| Forn, J; García Rafanell, J; Gómez, L | 1 |
| Bellido, I; Camara, S; Carrasco, T; de la Cruz, JP; Sanchez de la Cuesta, F | 1 |
| Le Breton, GC; Zaragoza, R | 1 |
| Abbate, R; Favilla, S; Gensini, GF; Neri Serneri, GG; Panetta, A; Pinto, S; Prisco, D | 1 |
| Delvos, U; Janssen, B; Müller-Berghaus, G | 1 |
| Nabata, H; Okazaki, A; Sakai, K; Uchino, M; Yamazaki, T | 1 |
| Beckman, BS; Fisher, JW; King, L; Mason-Garcia, M; Nystuen, L | 1 |
| Costantini, V; Goracci, G; Nenci, GG; Pistolesi, R; Porcellati, S; Porrovecchio, P; Prosdocimi, M | 1 |
| Ditschuneit, H; Fetzer, G; Gerber, K; Horn, H; Preclik, G; Schneider, A; Stange, EF | 1 |
| Alvarez, J; Bomalaski, JS; Touchstone, J; Zurier, RB | 1 |
| Bertrand, C; Frossard, N; Landry, Y; Tschirhart, E | 1 |
| Schrör, K; Verheggen, R | 1 |
| Constable, IJ; Croft, KD; Martin, CE; van Bockxmeer, FM | 1 |
| Fischer, C; Hecker, M; Meese, CO; Ullrich, V | 1 |
| Kantor, TG | 1 |
| Ishikawa, S; Kanai, Y; Kitagawa, Y; Manabe, S; Wada, O; Yanagisawa, H | 1 |
| Herold, M; Kogelnig, R; Kunz, F; Zwierzina, WD | 1 |
| Weksler, BB | 1 |
| Bertelé, V; Cerletti, C; Chen, ZM; de Gaetano, G | 1 |
| Lang, SA; Maron, MB | 1 |
| Anderson, WP; Bobik, A | 1 |
| Anderson, CB; Freeman, MB; Mangino, MJ; Neuberger, S; Sicard, GA; Valentin, LI | 1 |
| Picado, C; Plaza, V | 1 |
| Capdevila, J; Falck, JR; Gil, L; Marnett, LJ; Mason, JI; Orellana, M; Yadagiri, P | 1 |
| Berndt, J; Hamm, U; Krug, HF | 1 |
| Beckman, B; Nystuen, L | 1 |
| Boysen, G; Knudsen, JB; Petersen, P; Waldemar, G | 1 |
| Andries, R; Bourgain, RH; Braquet, P; Decuyper, K | 1 |
| Addya, S; Bhattacharya, DK; Chatterjee, GC; Mukhopadhyay, S | 1 |
| Allen, BT; Anderson, CB; Freeman, MB; McGoff, MA; Sicard, GA; Valentin, LI | 1 |
| Azami, K; Hasegawa, T; Hoshi, M; Ohura, T; Ono, I; Tsutsumi, M | 1 |
| Altman, R; Funes, JC; Scazziota, A | 1 |
| Kulmacz, RJ; Marshall, PJ | 1 |
| Becher, G; Siemers, R; Winsel, K | 1 |
| Bailey, JM; Makheja, AN; Pash, J; Verma, M | 1 |
| Wüthrich, B | 1 |
| Cassina, G; Livio, M; Macconi, D; Morelli, C; Morzenti, G; Remuzzi, G | 1 |
| Nakamura, Y; Sakai, K; Sugimoto, T; Yamazaki, T | 1 |
| Lefkowith, JB; Needleman, P | 1 |
| Delbridge, L; Handelsman, DJ; McLennan, S; Reeve, T; Turtle, JR; Yue, DK | 1 |
| Bonne, C; Descharmes, A; Gazel, P; Kalt, C; Legrand, A; Moneret-Vautrin, DA; Wayoff, M | 1 |
| Bertelé, V; Castagnoli, MN; Cerletti, C; de Gaetano, G; Rajtar, G | 1 |
| Setty, BN; Stuart, MJ; Walenga, RW | 1 |
| Mathews, KP; McLean, JA; Slepian, IK | 1 |
| Bailey, JM; Hla, T; Muza, B; Salata, K | 1 |
| Kulkarni, PS; Srinivasan, BD | 1 |
| Davies, JA; Menys, VC | 1 |
| Goswami, SK; Gould, RM | 1 |
| Amsallem, P; Escoubet, B; Ferrary, E; Tran Ba Huy, P | 1 |
| Ganguli, S; Miller, JD; Sperling, MA | 1 |
| Asbury, AC; Bliss, EL; Brown, V; Clemmons, RM; Cook, D; Lee, MR | 1 |
| Bar, RS; Dolash, S; Kaduce, TL; Marshall, SJ; Sandra, A; Spector, AA | 1 |
| Inoue, M; Kojima, T; Morikawa, M; Tsuboi, M | 2 |
| Kawakita, S; Nozaki, M; Ozaki, N; Saeki, Y; Takahashi, M | 1 |
| Odessey, R | 1 |
| Ferrier, GR; Karmazyn, M; Moffat, MP | 1 |
| Andries, R; Bourgain, RH; Deby, C | 1 |
| Peach, MJ; Shasby, DM; Shasby, SS | 1 |
| Atkinson, PM; Bradlow, BA; Chetty, N | 1 |
| Satake, N; Shibata, S; Ueda, S | 1 |
| Buchanan, MR; Butt, RW; Hirsh, J; Magas, Z; Nazir, DJ; van Ryn, J | 1 |
| Greene, CE | 1 |
| Bach, PH; Bridges, JW | 2 |
| Ameisen, JC; Capron, A; Fournier, E; Joseph, M; Maclouf, J; Pancré, V; Tonnel, AB; Vorng, H; Wallaert, B | 1 |
| Cerletti, C | 1 |
| Colwell, JA; Halushka, PV; Mayfield, R | 1 |
| Hoffmann, O; Klaushofer, K; Koller, K; Peterlik, M | 1 |
| Carlson, RP; Chang, J; Gilman, SC; Lewis, AJ | 1 |
| diZerega, GS; Nakamura, RM; Shimanuki, T | 1 |
| Einzig, S; Noren, GR; Rao, GH; Staley, NA; White, JG | 1 |
| Carter, AJ; Heptinstall, S | 1 |
| Courillon-Mallet, A; Wautier, JL | 1 |
| Colotta, F; de Gaetano, G; Semeraro, N; Villa, S | 1 |
| Dunn, MJ; Sato, M | 1 |
| Newman, JH; Sheller, JR | 1 |
| Adams, GA; Feuerstein, IA | 1 |
| Regal, JF | 1 |
| Fujimoto, Y; Fujita, T; Tanioka, H; Toibana, E; Yamamoto, T | 1 |
| Bhattacharya, SK; Das, N | 1 |
| Dixon, JF; Hokin, LE; Marshall, PJ | 1 |
| Davis, BB; Rapp, NS; Zenser, TV | 1 |
| Davis, BB; Rapp, NS; Spry, LA; Zenser, TV | 1 |
| Bergqvist, D | 1 |
| Anderson, JB; Lessof, MH | 1 |
| Hiraku, S; Iizuka, K; Katsube, N; Kawasaki, A; Komatsu, H; Naito, J; Tsuboshima, M; Ujiie, A; Wakitani, K | 1 |
| Corzo, J; Fremont-Smith, M; Guarner, F; Prieto, J; Quiroga, J; Rodriguez, JL | 1 |
| Mitchell, JR | 1 |
| Callow, AD; Connolly, RJ; Keough, EM; Mackey, WC; McCullough, JL; Melaragno, A; O'Donnell, TF; Ramberg-Laskaris, K; Valeri, CR; Weiblen, B | 1 |
| Hata, S; Koide, T; Matsushita, H; Mizukami, M; Nakano, M; Neichi, T; Noda, Y; Yamazaki, T | 1 |
| Fleischman, JA; Henry, RL; Nalbandian, RM; O'Donnell, FE; Reeser, FH; Williams, GA | 1 |
| Mahmud, I; Miura, Y | 1 |
| Badwey, JA; Curnutte, JT; Karnovsky, ML | 1 |
| Bianchine, J; Greenwald, JE; Metz, EN; Sagone, AL; Singh, D | 1 |
| Kazmi, GM; Littner, MR; Lott, FD | 1 |
| Aikawa, M; Dunn, M; Hassid, A; Pugliese, F; Sato, M; Williams, S | 1 |
| Aonuma, S; Fujimoto, S; Kohama, Y; Nomura, M; Yamahata, E | 1 |
| Hunt, NH; Lim, LK; Weidemann, MJ | 1 |
| Majerus, PW | 1 |
| Cockbill, SR; Cowley, AJ; Hanley, SP; Heptinstall, S; Jones, EW | 1 |
| Di Minno, G; Murphy, S; Silver, MJ | 1 |
| Nakamizo, N; Shuto, K; Yamada, K | 1 |
| Cragg, DB; Forrest, JB; Todd, MH | 1 |
| Seale, JP | 2 |
| Goerz, G; Merk, H | 1 |
| Granström, E; Lundström, V; Swahn, ML | 1 |
| Mehta, J; Roberts, A | 1 |
| Catalano, PM; De Marco, L; Di Minno, G; Murphy, S; Shapiro, SS | 1 |
| Rimele, TJ; Vanhoutte, PM | 1 |
| Dore-Duffy, P; Kuo, HH; Perry, W | 1 |
| Leid, RW; McConnell, LA | 1 |
| Gryglewski, RJ; Szczeklik, A | 1 |
| Feuer, C; Johnston, MG | 1 |
| Fujimura, H; Tsurumi, K | 1 |
| Borda, E; Gimeno, AL; Gimeno, MF; Lazzari, MA; Shattner, MA | 1 |
| Dahl, ML; Matintalo, M; Puustinen, T; Uotila, P | 1 |
| Buchanan, MR; Gimbrone, MA; Vazquez, MJ | 1 |
| Lapetina, EG; Siess, W | 1 |
| Cockrell, CS; Ellis, EF; Nelson, GH; Rosenblum, WI | 1 |
| Brotherton, AF; Hoak, JC | 1 |
| Corell, T; Hasselmann, G; Jakubek, B; Nieszpaur, M; Spławińska, B; Spławiński, J | 1 |
| Hoak, JC | 1 |
| Paajanen, H; Schalin, M; Simberg, N; Uotila, P | 1 |
| Lüthy, C; Multhaupt, M; Oetliker, O; Perisic, M | 1 |
| Ali, M; de Kergommeaux, BD; Hayward, CP; McDonald, JW | 1 |
| Anggård, E | 1 |
| Grilliat, JP; Moneret-Vautrin, DA; Reynier, A; You, B | 1 |
| Borda, ES; de Bracco, MM; Finiasz, M; Sterin-Borda, L | 1 |
| Crawford, DD; Gimbrone, MA; Schafer, AI | 1 |
| Dugdale, M; Johnson, RW; Lasslo, A; Naylor, JL; Quintana, RP | 1 |
| Lapetina, EG; Siess, W; Weber, PC | 1 |
| Cullen, E | 1 |
| Guccione, MA; Kinlough-Rathbone, RL; Mustard, JF; Nina, M; Packham, MA | 1 |
| Cerskus, I; Killackey, BA; Killackey, JJ; Philp, RB | 1 |
| Evangelista, S; Giolitti, A; Grimaldi, G; Maggi, CA; Meli, A; Santicioli, P | 1 |
| Mäntylä, E; Punnonen, K; Uotila, P | 1 |
| Agozzino, S; Bellavite, O; Donà, GC; Pagella, PG | 1 |
| Laitinen, O; Seppälä, E; Vapaatalo, H | 1 |
| Collier, HO; McDonald-Gibson, RG; McDonald-Gibson, WJ; Power, GM | 1 |
| Brash, A; Fitzgerald, G; Oates, JA | 1 |
| DeSchryver-Kecskemeti, K; Lefkowith, JB; Needleman, P; Okegawa, T | 1 |
| Lewis, GP; Smith, JR | 1 |
| Huston, L; Leid, RW; Liggitt, HD | 1 |
| Adams, T; Manley, G; Steiner, S | 1 |
| Chap, H; Douste-Blazy, L; Hullin, F; Thomas, JM | 1 |
| Punnonen, K; Uotila, P | 1 |
| Agostini, MD; Borda, ES; Gimeno, MF; Peredo, H | 1 |
| Bergamaschi, M; Branzoli, U; Pierucci, L | 1 |
| Leĭtin, VL; Mazurov, AB; Repin, VS | 1 |
| Talesnik, J; Tsoporis, JN | 1 |
| Borda, E; Cremaschi, G; Genaro, AM; Sales, ME; Sterin-Borda, L | 1 |
| Dahl, ML; Uotila, P | 1 |
| Arese, P; Bosia, A; Caruso, D; Galli, G; Hofmann, J; Lösche, W; Paoletti, R; Pescarmona, GP; Spangenberg, P; Till, U | 1 |
| Förster, W; Leytin, VL; Mazurov, AV; Repin, VS; Taube, C | 1 |
| Förster, W; Mest, HJ; Zehl, U | 1 |
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| Dannenberg, L; Hohlfeld, T; Kelm, M; Levkau, B; Polzin, A; Sansone, R; Zeus, T | 1 |
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| Ando, H; Furuki, Y; Hagiwara, N; Ishida, I; Jujo, K; Nakabayashi, K; Saito, K; Shimizu, M | 1 |
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| Bartrop, R; Buckley, T; Dent, J; Fethney, J; Havyatt, J; McKinley, S; Mihailidou, AS; Morel-Kopp, MC; Prigerson, HG; Spinaze, M; Tofler, GH; Ward, C; Whitfield, V | 1 |
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| Ballerini, P; Bruno, A; Contursi, A; D'Agostino, I; Dovizio, M; Falcone, L; Fullone, R; Mucci, M; Patrignani, P; Sacco, A; Tacconelli, S; Zucchelli, M | 1 |
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| Cho, HJ; Choi, HY; Choi, S; Jang, HJ; Jang, SS; Jeon, S; Kim, DE; Kim, H; Kim, J; Kim, K; Kim, YD; Kwon, IC; Lee, KY; Lee, SK; Nahrendorf, M; Ryu, WS; Schellingerhout, D | 1 |
| Aungraheeta, R; Baos, S; Baumbach, A; Bowles, R; Collett, L; Hutchinson, JL; Johnson, TW; Molina, M; Mumford, AD; Mundell, SJ; Nkau, M; Reeves, BC; Reilly-Stitt, C; Rogers, CA | 1 |
| Blomqvist, LRF; Hellgren, MSE; Jeppsson, A; Strandell, AM | 1 |
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| Barrett, TJ; Berger, JS; Heffron, SP; Voora, D; Windheim, J | 1 |
| Anaya, FJ; Henry, K; Hong, J; Innis, RB; Kim, MJ; Lee, JH; Liow, JS; Manly, LS; Pike, VW; Santamaria, JAM; Shetty, HU; Shrestha, S; Telu, S; Zanotti-Fregonara, P; Zoghbi, SS | 1 |
| Baucom, MR; England, L; Goodman, MD; Pritts, TA; Schuster, R; Turner, K; Wallen, TE; Youngs, J | 1 |
| Alasadi, Y; Asgar, JA; Bliden, KP; Chaudhary, R; Duhan, S; Gill, H; Gurbel, PA; Kundan, P; Sharma, T; Singh, A; Tantry, US | 1 |
| Honma, M; Kariya, Y; Konagaya, A; Suzuki, H; Tokuda, K | 1 |
| Mohammed, A; Shoemaker, RH | 1 |
| Blaha, V; Carazo, A; Hrubša, M; Javorská, L; Karlíčková, J; Konečný, L; Krčmová, LK; Matoušová, K; Mladěnka, P; Musil, F; Paclíková, M; Parvin, MS; Skořepa, P; Šmahelová, A | 1 |
| Bender, L; Dorn, C; Franko, M; Franz, C; May, R; Minkenberg, J; Nikoubashman, O; Ridwan, H; Sichtermann, T; Stockero, A; Wiesmann, M | 1 |
| Cao, J; Chen, R; Gao, P; Gu, X; Jia, W; Ma, W; Qiu, S; Shen, S; Sun, L; Suo, C; Wei, H; Yan, R; Zhang, H; Zhang, P; Zhang, T | 1 |
| Gao, ST; Ma, L; Wang, Y | 1 |
60 review(s) available for aspirin and arachidonic acid
| Article | Year |
|---|---|
Aspirin sensitive asthma.
Topics: Animals; Arachidonic Acid; Aspirin; Asthma; Blood Platelets; Drug Hypersensitivity; Humans; Leukocytes; Leukotriene Antagonists; Leukotrienes; Rest; Virus Diseases | 1992 |
Arachidonic acid metabolism in the pathophysiology and prevention of preeclampsia--a review.
Topics: Arachidonic Acid; Aspirin; Female; Fish Oils; Humans; Pre-Eclampsia; Pregnancy; Risk | 1991 |
The cyclooxygenase theory of aspirin-induced asthma.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Blood Platelets; Cyclooxygenase Inhibitors; Drug Hypersensitivity; Humans; Leukotrienes; Lung; Virus Diseases | 1990 |
Platelets as a source of vasoactive mediators.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Endothelium, Vascular; Humans; Prostaglandins; Serotonin; Thromboxane A2; Vasomotor System | 1990 |
Clinical pharmacology and use of nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Arthritis, Juvenile; Aspirin; Child; Child, Preschool; Drug Interactions; Eicosanoids; Humans; Inflammation; Prostaglandins | 1989 |
Platelets and prostaglandins in sudden death: therapeutic implications.
Topics: Adrenergic beta-Antagonists; Animals; Arachidonic Acid; Arachidonic Acids; Arteriosclerosis; Aspirin; Blood Platelets; Coronary Disease; Death, Sudden; Dipyridamole; Humans; Myocardial Infarction; Platelet Aggregation; Prostaglandins; Risk; Sulfinpyrazone; Thrombosis | 1985 |
[Platelet function inhibitors in peripheral arteriopathies].
Topics: Adrenal Cortex Hormones; Adrenergic alpha-Antagonists; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Arteriosclerosis Obliterans; Aspirin; Blood Platelets; Calcium Channel Blockers; Clinical Trials as Topic; Cyclic AMP; Dipyridamole; Extremities; Heparin; Humans; Imidazoles; Prostaglandins; Prostanoic Acids; Pyrazoles; Pyrazolones; Quinacrine; Thiophenes; Thromboembolism; Thrombosis; Ticlopidine; Vascular Diseases | 1986 |
Control of polyunsaturated acids in tissue lipids.
Topics: Acrodermatitis; alpha-Linolenic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Child; Crohn Disease; Cystic Fibrosis; DDT; Dicofol; Ethanol; Fatty Acids, Essential; Fatty Acids, Unsaturated; Female; Humans; Ichthyosis; Indomethacin; Isomerism; Linoleic Acid; Linoleic Acids; Linolenic Acids; Lipid Metabolism; Lipolysis; Liver Cirrhosis, Alcoholic; Models, Chemical; Myocardial Infarction; Protein-Energy Malnutrition; Reye Syndrome; Structure-Activity Relationship | 1986 |
Prostaglandins and other metabolites of arachidonic acid. An overview for the otolaryngologist.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Epoprostenol; Humans; Hypersensitivity; Indomethacin; Inflammation; Leukotriene A4; Lipoxygenase; Neoplasms; Phospholipases; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Thromboxanes | 1985 |
Allergic and pseudoallergic reactions to non-narcotic analgesics.
Topics: Analgesics; Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Drug Hypersensitivity; Humans; Prostaglandins | 1986 |
[Asthma and platelets].
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Blood Platelets; Drug Tolerance; Humans; Platelet Activating Factor | 1988 |
[Acetylsalicylic acid pseudoallergy: an anomaly of thrombocyte function?].
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Blood Platelets; Drug Hypersensitivity; Humans; Nasal Polyps; Prostaglandin-Endoperoxide Synthases; Status Asthmaticus | 1988 |
Aspirin-sensitive asthma.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Desensitization, Immunologic; Drug Hypersensitivity; Humans; Prostaglandin Antagonists | 1985 |
Chemically induced renal papillary necrosis and upper urothelial carcinoma. Part 1.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Carbohydrate Metabolism; Female; Glycosaminoglycans; Hemodynamics; Humans; Kidney Medulla; Kidney Papillary Necrosis; Lipid Metabolism; Male; Middle Aged; Nephrons; Phenacetin; Renal Circulation; Urinary Bladder Neoplasms | 1985 |
Insulin and arachidonic acid metabolism in diabetes mellitus.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arthritis, Rheumatoid; Aspirin; Blood Platelets; Diabetes Mellitus; Epoprostenol; Humans; Insulin; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1985 |
Arachidonic acid metabolites in the healthy and diseased lung.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Bronchitis; Dinoprost; Dinoprostone; Epoprostenol; Humans; Leukotriene B4; Lung; Lung Diseases; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins D; Prostaglandins E; Prostaglandins F; Prostaglandins G; Prostaglandins H; Pulmonary Circulation; Pulmonary Ventilation; SRS-A | 1984 |
Pharmacological prevention of thrombotic occlusion in arterial reconstructive surgery.
Topics: Arachidonic Acid; Arachidonic Acids; Arterial Occlusive Diseases; Aspirin; Blood Platelets; Cyclic AMP; Dextrans; Dipyridamole; Heparin; Humans; Risk; Thrombin; Thrombosis; Vascular Surgical Procedures | 1983 |
Prostaglandins and other mediators in food intolerance.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Autacoids; Chemotactic Factors; Cyclooxygenase Inhibitors; Cytoplasmic Granules; Food Hypersensitivity; Gastrointestinal Diseases; Histamine; Histamine Release; Humans; Interleukin-8; Intestinal Mucosa; Lymphoid Tissue; Mast Cells; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Urticaria | 1984 |
Clinical aspects of the arachidonic acid--thromboxane pathway.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Coagulation; Cerebrovascular Disorders; Epoprostenol; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation; Receptors, Prostaglandin; Receptors, Thromboxane; Thrombosis; Thromboxane A2; Thromboxane-A Synthase | 1983 |
Arachidonate metabolism in vascular disorders.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Blood Vessels; Cyclic AMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium; Epoprostenol; Fatty Acids, Unsaturated; Fibrinolytic Agents; Humans; Thromboxane A2; Thromboxane-A Synthase; Vascular Diseases | 1983 |
The possible roles of prostaglandins and related compounds in endometrial bleeding. A mini-review.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Endometrium; Endothelium; Epoprostenol; Female; Fibrin; Hemostasis; Humans; Intrauterine Devices; Menstruation; Prostaglandin Endoperoxides; Prostaglandins; Thromboxane A2; Uterine Hemorrhage; Uterus | 1983 |
The role of phospholipase C in platelet responses.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Diglycerides; Enzyme Activation; Humans; Phosphatidic Acids; Phospholipases; Phospholipases A; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thrombin; Thromboxane A2; Type C Phospholipases | 1983 |
Mechanisms of action: aspirin.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Endothelium; Humans; Ibuprofen; In Vitro Techniques; Indomethacin; Salicylates; Salicylic Acid; Thromboxanes | 1983 |
Novel anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Carboxylic Acids; Dapsone; Humans; Immunity; Indomethacin; Prostaglandin Antagonists; Rats; Tilorone | 1984 |
[Arachidonic acid metabolism and platelet function in diabetics (author's transl)].
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Diabetes Mellitus; Epoprostenol; Humans; Imidazoles; Platelet Aggregation; Platelet Function Tests; Rats; Rats, Inbred Strains | 1981 |
Prostaglandins, slow-reacting substances (leukotrienes) and the lung.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Bronchi; Epoprostenol; Guinea Pigs; Humans; Indomethacin; Infant, Newborn; Lung; Lung Diseases, Obstructive; Prostaglandin-Endoperoxide Synthases; Prostaglandins; SRS-A; Thromboxanes | 1981 |
[Action mechanism of platelet suppressants and platelet suppressant therapy].
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Heparin; Humans; Ischemic Attack, Transient; Nephrotic Syndrome; Platelet Aggregation | 1981 |
Aspirin--now we can see it.
Topics: Acetylation; Animals; Arachidonic Acid; Aspirin; Binding Sites; Computer Simulation; Cyclooxygenase Inhibitors; Flurbiprofen; Isoenzymes; Models, Molecular; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Protein Binding; Serine; Sheep | 1995 |
Aspirin and related nonsteroidal anti-inflammatory drugs as chemopreventive agents against colon cancer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Colon; Colonic Neoplasms; Cyclooxygenase Inhibitors; Humans; Prostaglandin-Endoperoxide Synthases; Prostaglandins | 1995 |
Principles of platelet inhibitor therapy--where we stood in 1993.
Topics: Animals; Arachidonic Acid; Aspirin; Blood Platelets; Coronary Circulation; Coronary Disease; Endothelium, Vascular; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins; Receptors, Cell Surface | 1994 |
Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis.
Topics: Anti-Inflammatory Agents; Arachidonic Acid; Arteriosclerosis; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Endothelium, Vascular; Fibrinolytic Agents; Hemorrhage; Humans; Isoenzymes; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Thrombosis | 1997 |
Relation of platelet abnormalities to thrombosis and hemorrhage in chronic myeloproliferative disorders.
Topics: Alkylating Agents; Arachidonic Acid; Aspirin; Bleeding Time; Blood Platelets; Bone Marrow; Hematopoiesis; Hemorrhage; Hemorrhagic Disorders; Humans; Interferon-alpha; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Megakaryocytes; Myeloproliferative Disorders; Phlebotomy; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Signal Transduction; Thrombophilia; Thrombosis | 1997 |
Mechanism of anti-proliferative action of eicosapentaenoic acid (EPA) in vascular cell growth: its effect on signal transduction system.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arteriosclerosis; Arteriosclerosis Obliterans; Aspirin; Cell Division; Cells, Cultured; Clinical Trials as Topic; Eicosanoids; Eicosapentaenoic Acid; Epoprostenol; Fibrinolytic Agents; Growth Inhibitors; Hemostasis; Humans; Hypolipidemic Agents; Muscle, Smooth, Vascular; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Signal Transduction; Thrombophilia; Thrombosis; Thromboxane A2 | 1997 |
The use of aspirin in polycythaemia vera and primary thrombocythaemia.
Topics: Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Humans; Platelet Aggregation Inhibitors; Polycythemia Vera; Thrombocythemia, Essential; Thrombosis; Vascular Diseases | 1998 |
[Aspirin-induced asthma and nose diseases].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Asthma; Female; Humans; Male; Nasal Polyps; Nose Diseases | 2000 |
Translational medicine: targetting cyclo-oxygenase isozymes to prevent cancer.
Topics: Arachidonic Acid; Aspirin; Cardiovascular Diseases; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Design; Humans; Isoenzymes; Lactones; Membrane Proteins; Neoplasms; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Randomized Controlled Trials as Topic; Sulfonamides; Sulfones | 2002 |
Possible mechanisms of aspirin resistance.
Topics: Animals; Arachidonic Acid; Aspirin; Drug Resistance; Humans; Myocardial Infarction; Platelet Aggregation; Risk Factors | 2002 |
[Asthma and aspirin].
Topics: Administration, Oral; Adrenal Cortex Hormones; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Asthma; Cyclooxygenase Inhibitors; Desensitization, Immunologic; Female; Fibrinolytic Agents; Humans; Leukotrienes; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Sex Factors | 2003 |
Aspirin-induced asthma: clinical aspects, pathogenesis and management.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Asthma; Glutathione Transferase; Humans; Prostaglandin-Endoperoxide Synthases | 2004 |
Mechanisms of aspirin sensitivity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 15-Lipoxygenase; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Aspirin; Asthma; Drug Hypersensitivity; Humans; Lipoxins; Prostaglandin-Endoperoxide Synthases | 2006 |
Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins.
Topics: Acetylation; Animals; Anti-Inflammatory Agents; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arthritis; Aspirin; Asthma; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Inflammation; Lipoxins; Periodontitis | 2006 |
Novel chemical mediators in the resolution of inflammation: resolvins and protectins.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; CD59 Antigens; Complement Inactivating Agents; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Humans; Inflammation; Neuroprotective Agents | 2006 |
Aspirin-sensitive rhinosinusitis and asthma.
Topics: Arachidonic Acid; Aspirin; Asthma; Desensitization, Immunologic; Drug Hypersensitivity; Humans; Inflammation; Leukotriene C4; Nasal Polyps; Prostaglandin-Endoperoxide Synthases; Rhinitis; Sinusitis | 2007 |
Aspirin resistance: does it exist?
Topics: Arachidonic Acid; Aspirin; Clinical Laboratory Techniques; Cyclooxygenase 1; Diagnostic Errors; Drug Resistance; Humans | 2007 |
[Resolvins: new derivates of fatty acids, polyunsaturated (omega-3) with therapeutic potential in inflammatory intestinal diseases].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Humans; Inflammatory Bowel Diseases; Treatment Outcome | 2006 |
Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis.
Topics: Animals; Antineoplastic Agents; Arachidonic Acid; Aspirin; Cell Cycle Proteins; Cell Proliferation; Cyclooxygenase 2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fatty Acids, Omega-3; Humans; Neoplasms; Neovascularization, Pathologic; Pyrazoles | 2009 |
Antiplatelets and stroke outcomes: state of the science.
Topics: Arachidonic Acid; Aspirin; Aspirin, Dipyridamole Drug Combination; Brain Ischemia; Clopidogrel; Dipyridamole; Drug Combinations; Evidence-Based Practice; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Risk Reduction Behavior; Safety; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2009 |
New insights on the possible role of mast cells in aspirin-induced asthma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Asthma, Aspirin-Induced; Dinoprost; HSP70 Heat-Shock Proteins; Humans; Leukotrienes; Mast Cells; Phosphoric Monoester Hydrolases; Prostaglandin-Endoperoxide Synthases; Toll-Like Receptors | 2009 |
[Significance of platelet function tests].
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelet Disorders; Clopidogrel; Collagen; Hemorrhagic Disorders; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prognosis; Ristocetin; Ticlopidine | 2010 |
Management of type-2 diabetes with anti-platelet therapies: special reference to aspirin.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Diabetes Mellitus, Type 2; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Thienopyridines; Ticlopidine; Vascular Diseases | 2011 |
Antiplatelet therapy in peripheral artery disease.
Topics: Ankle Brachial Index; Arachidonic Acid; Aspirin; Humans; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists | 2012 |
Mechanisms of aspirin desensitization.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Desensitization, Immunologic; Drug Hypersensitivity; Eosinophils; Gene Expression Regulation; Humans; Interleukin-4; Mast Cells; Receptors, Leukotriene | 2013 |
Systematic review: interactions between aspirin, and other nonsteroidal anti-inflammatory drugs, and polymorphisms in relation to colorectal cancer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arachidonic Acid; Aspirin; Colorectal Neoplasms; Cytokines; Drug Interactions; Gene-Environment Interaction; Humans; Polymorphism, Genetic; Wnt Signaling Pathway | 2014 |
COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cyclooxygenase 2; Docosahexaenoic Acids; Eicosapentaenoic Acid; Humans | 2016 |
Membrane and inhibitor interactions of intracellular phospholipases A2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cell Membrane; Eukaryotic Cells; Gene Expression Regulation; Humans; Hydroxyurea; Lipoxygenase; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; Phospholipases A2; Phospholipids; Prostaglandin-Endoperoxide Synthases; Signal Transduction | 2016 |
Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Drug Therapy, Combination; Eicosapentaenoic Acid; Humans; Respiratory Distress Syndrome; Sepsis | 2016 |
Is arachidonic acid stimulation really a test for the response to aspirin? Time to think again?
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Cardiovascular Diseases; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reproducibility of Results; Thrombosis | 2017 |
Aspirin exacerbated respiratory disease: Current topics and trends.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arachidonic Acid; Aspirin; Asthma; Asthma, Aspirin-Induced; Cysteine; Cytokines; Desensitization, Immunologic; Dinoprostone; Disease Progression; Drug Hypersensitivity Syndrome; Eosinophils; Female; Humans; Leukotrienes; Male; Mast Cells; Nasal Polyps; Respiratory Tract Diseases; Rhinitis; Sinusitis; Thymic Stromal Lymphopoietin | 2018 |
THERAPEUTIC TARGETING OF BRAIN ARACHIDONIC ACID CASCADE IN BIPOLAR DISORDER BY LOW DOSE ASPIRIN AND CELECOXIB.
Topics: Arachidonic Acid; Aspirin; Bipolar Disorder; Brain; Celecoxib; Humans; Randomized Controlled Trials as Topic | 2020 |
Sex-Related Differences in Platelet Aggregation: A Literature Review Supplemented with Local Data from a Group of Generally Healthy Individuals.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Female; Humans; Lactones; Male; Platelet Aggregation; Platelet Aggregation Inhibitors | 2023 |
76 trial(s) available for aspirin and arachidonic acid
| Article | Year |
|---|---|
A randomized placebo-controlled study of the effect of low dose aspirin on platelet reactivity and serum thromboxane B2 production in non-pregnant women, in normal pregnancy, and in gestational hypertension.
Topics: Adult; Arachidonic Acid; Aspirin; Collagen; Female; Humans; Hypertension; Platelet Aggregation; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy Complications, Cardiovascular; Thromboxane B2 | 1992 |
Roles of deoxycholate and arachidonate in pathogenesis of cholesterol gallstones in obese patients during rapid loss of weight.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Cholelithiasis; Cholesterol; Deoxycholic Acid; Dinoprostone; Double-Blind Method; Glycoproteins; Humans; Obesity; Ursodeoxycholic Acid; Weight Loss | 1991 |
Arachidonic acid metabolism in the pathophysiology and prevention of preeclampsia--a review.
Topics: Arachidonic Acid; Aspirin; Female; Fish Oils; Humans; Pre-Eclampsia; Pregnancy; Risk | 1991 |
A study on the optimal dose of aspirin therapy in Kawasaki disease--clinical evaluation and arachidonic acid metabolism.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Chi-Square Distribution; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Mucocutaneous Lymph Node Syndrome; Prostaglandins F; Thromboxane B2 | 1990 |
Response of thromboxane B2, malondialdehyde and platelet sensitivity to 3 weeks low-dose aspirin (ASA) in healthy volunteers.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Epoprostenol; Female; Humans; In Vitro Techniques; Male; Malonates; Malondialdehyde; Platelet Aggregation; Thromboxane B2 | 1989 |
[Platelet function inhibitors in peripheral arteriopathies].
Topics: Adrenal Cortex Hormones; Adrenergic alpha-Antagonists; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Arteriosclerosis Obliterans; Aspirin; Blood Platelets; Calcium Channel Blockers; Clinical Trials as Topic; Cyclic AMP; Dipyridamole; Extremities; Heparin; Humans; Imidazoles; Prostaglandins; Prostanoic Acids; Pyrazoles; Pyrazolones; Quinacrine; Thiophenes; Thromboembolism; Thrombosis; Ticlopidine; Vascular Diseases | 1986 |
Role of proaggregatory and antiaggregatory prostaglandins in hemostasis. Studies with combined thromboxane synthase inhibition and thromboxane receptor antagonism.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Bleeding Time; Cyclooxygenase Inhibitors; Hemostasis; Humans; Imidazoles; Indomethacin; Male; Platelet Aggregation; Prostaglandins; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane-A Synthase | 1987 |
Effects of salicylic and acetylsalicylic acid alone and in combination on platelet aggregation and prostanoid synthesis in man.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Dinoprostone; Diuresis; Drug Interactions; Electrolytes; Humans; Platelet Aggregation; Prostaglandins; Prostaglandins E; Random Allocation; Salicylates; Thromboxane B2 | 1986 |
Inhibition of arachidonic acid metabolism in the perinatal period: pharmacology, clinical application, and potential adverse effects.
Topics: Administration, Oral; Arachidonic Acid; Arachidonic Acids; Aspirin; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Double-Blind Method; Ductus Arteriosus, Patent; Female; Hemodynamics; Humans; Indomethacin; Maternal-Fetal Exchange; Obstetric Labor, Premature; Platelet Aggregation; Pregnancy; Pulmonary Circulation; Random Allocation; Uterine Contraction | 1986 |
Platelet aggregation in human whole blood after chronic administration of aspirin.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Cells; Cell Separation; Collagen; Dose-Response Relationship, Drug; Epinephrine; Humans; In Vitro Techniques; Male; Platelet Aggregation; Research Design | 1987 |
Inhibition of platelet function by low-dose plain and micro-encapsulated acetylsalicylic acid.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Bleeding Time; Blood Platelets; Double-Blind Method; Drug Compounding; Humans; Male; Platelet Aggregation; Platelet Function Tests; Tablets; Thromboxane B2 | 1988 |
[Therapeutic prospects and prostaglandins in vascular pathology].
Topics: Angina Pectoris; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Arteritis; Aspirin; Blood Platelets; Cardiovascular Diseases; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Epoprostenol; Female; Humans; Male; Myocardial Infarction; Prostaglandins; Raynaud Disease; Thromboxanes | 1985 |
Effects of low-dose aspirin on in vitro platelet aggregation in the early minutes after ingestion in normal subjects.
Topics: Administration, Oral; Adult; Arachidonic Acid; Aspirin; Cross-Over Studies; Female; Humans; Longitudinal Studies; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Time Factors | 1994 |
Effect of diltiazem and low-dose aspirin on platelet aggregation and ATP release induced by paired agonists.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Arachidonic Acid; Aspirin; Bleeding Time; Blood Platelets; Diltiazem; Drug Synergism; Epinephrine; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors | 1993 |
Platelet aggregation in patients with atrial fibrillation taking aspirin or warfarin.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Atrial Fibrillation; Cerebrovascular Disorders; Collagen; Epinephrine; Humans; In Vitro Techniques; Kinetics; Platelet Aggregation; Warfarin | 1993 |
Anti-platelet effects of 100 mg alternate day oral aspirin: a randomized, double-blind, placebo-controlled trial of regular and enteric coated formulations in men and women.
Topics: Adenosine Diphosphate; Administration, Oral; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cardiovascular Diseases; Double-Blind Method; Drug Administration Schedule; Epinephrine; Epoprostenol; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Radioimmunoassay; Risk Factors; Thromboxanes | 1996 |
A comparison of the effects of aspirin on bleeding time measured using the Simplate method and closure time measured using the PFA-100, in healthy volunteers.
Topics: Adult; Aged; Arachidonic Acid; Aspirin; Bleeding Time; Double-Blind Method; Humans; Male; Middle Aged; Placebos; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values | 1997 |
Platelet responses to several agonists and combinations of agonists in whole blood: a placebo controlled comparison of the effects of a once daily dose of plain aspirin 300 mg, plain aspirin 75 mg and enteric coated aspirin 300 mg, in man.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Coagulants; Collagen; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Male; Placebos; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Ristocetin; Streptokinase; Tablets, Enteric-Coated | 1997 |
Effect of salicis cortex extract on human platelet aggregation.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Collagen; Double-Blind Method; Female; Furosemide; Humans; Low Back Pain; Male; Medicine, Traditional; Middle Aged; Phytotherapy; Plant Extracts; Plant Stems; Plants, Medicinal; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Portugal | 2001 |
Effects of two preparations of 75-mg extended-release aspirin on platelet aggregation, prostanoids and nitric oxide production in humans.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Capsules; Cross-Over Studies; Delayed-Action Preparations; Epoprostenol; Female; Humans; Leukocytes; Male; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandins; Single-Blind Method | 2002 |
Celecoxib does not affect the antiplatelet activity of aspirin in healthy volunteers.
Topics: Adenosine Diphosphate; Adolescent; Adult; Arachidonic Acid; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Female; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thromboxane B2 | 2002 |
Functional and biochemical evaluation of platelet aspirin resistance after coronary artery bypass surgery.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Coronary Artery Bypass; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Activation; Humans; Indomethacin; Isoenzymes; Membrane Proteins; P-Selectin; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Pyridines; Thromboxane-A Synthase; Thromboxanes; Time Factors | 2003 |
Combination antiplatelet therapy in patients with peripheral vascular bypass grafts.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Drug Therapy, Combination; Female; Flow Cytometry; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Peripheral Vascular Diseases; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Prospective evaluation of the relationship between platelet-leukocyte conjugate formation and recurrent myocardial ischemia in patients with acute coronary syndromes.
Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Aged; Angina, Unstable; Arachidonic Acid; Aspirin; Blood Platelets; C-Reactive Protein; Cell Aggregation; Drug Resistance; Eptifibatide; Female; Heparin; Humans; Leukocytes; Male; Middle Aged; Monocytes; Multivariate Analysis; Myocardial Infarction; Myocardial Ischemia; Neutrophils; Patient Selection; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Receptors, Thrombin; Recurrence; ROC Curve; Tirofiban; Treatment Outcome; Troponin I; Tyrosine | 2004 |
Acetylsalicylic acid, diclofenac, and lornoxicam, but not rofecoxib, affect platelet CD 62 expression.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Flow Cytometry; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Piroxicam; Platelet Function Tests; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Selectins; Sulfones | 2004 |
Anti-platelet effect of aspirin is substantially reduced after administration of heparin during carotid endarterectomy.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Carotid Stenosis; Drug Interactions; Endarterectomy, Carotid; Female; Fibrinolytic Agents; Heparin; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Time Factors | 2004 |
Enhanced antiplatelet effects of clopidogrel plus acetylsalicylic acid compared with acetylsalicylic acid alone or combined with extended-release dipyridamole in healthy volunteers.
Topics: Adult; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Collagen; Cross-Over Studies; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination; Humans; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Compliance as a critical consideration in patients who appear to be resistant to aspirin after healing of myocardial infarction.
Topics: Arachidonic Acid; Aspirin; Drug Resistance; Humans; Myocardial Infarction; Patient Compliance; Platelet Aggregation Inhibitors | 2005 |
Lumiracoxib does not affect the ex vivo antiplatelet aggregation activity of low-dose aspirin in healthy subjects.
Topics: Adolescent; Adult; Arachidonic Acid; Aspirin; Collagen; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Epoprostenol; Female; Humans; Male; Middle Aged; Organic Chemicals; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2005 |
Enhanced antiplatelet effect of clopidogrel in patients whose platelets are least inhibited by aspirin: a randomized crossover trial.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Biomarkers; Clopidogrel; Collagen; Cross-Over Studies; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Peripheral Vascular Diseases; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Sex differences in platelet reactivity and response to low-dose aspirin therapy.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Cardiovascular Diseases; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Regression Analysis; Sex Factors | 2006 |
Heterogeneity in the suppression of platelet cyclooxygenase-1 activity by aspirin in coronary heart disease.
Topics: Aged; Arachidonic Acid; Aspirin; Blood Platelets; Calcimycin; Coronary Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Female; Humans; Indans; Lipopolysaccharides; Male; Middle Aged; Neutrophils; Thromboxane A2; Thromboxane B2 | 2006 |
Effect of aspirin dose, preparation, and withdrawal on platelet response in normal volunteers.
Topics: Adult; Aged; Arachidonic Acid; Aspirin; Humans; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Tablets, Enteric-Coated | 2006 |
Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Celecoxib; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Ibuprofen; Male; Middle Aged; Myocardial Ischemia; Osteoarthritis; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Pyrazoles; Sulfonamides; Thromboxane B2; Treatment Outcome | 2006 |
Normalization of platelet reactivity in clopidogrel-treated subjects.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fibrinogen; Humans; Male; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Transfusion; Platelet-Rich Plasma; Postoperative Hemorrhage; Receptors, Thrombin; Recovery of Function; Reference Values; Ticlopidine; Time Factors | 2007 |
Human pharmacology of naproxen sodium.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Humans; Lipopolysaccharides; Monocytes; Naproxen; Platelet Aggregation; Thromboxane B2 | 2007 |
Variable platelet response to aspirin in patients with ischemic stroke.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Biological Availability; Blood Platelets; Brain Ischemia; Collagen; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Middle Aged; Patient Compliance; Platelet Aggregation; Platelet Aggregation Inhibitors; Stroke; Thromboxane B2; Treatment Outcome | 2007 |
Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Coronary Disease; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Female; Flow Cytometry; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Thrombelastography; Thromboxane B2 | 2007 |
Platelet function measured by VerifyNow identifies generalized high platelet reactivity in aspirin treated patients.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Collagen; Coronary Artery Disease; Cross-Over Studies; Double-Blind Method; Female; Fibrinogen; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; von Willebrand Factor | 2007 |
Variable responsiveness to clopidogrel and aspirin among patients with acute coronary syndrome as assessed by platelet function tests.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet-Rich Plasma; ROC Curve; Sensitivity and Specificity; Ticlopidine | 2008 |
Population pharmacodynamic modelling of aspirin- and Ibuprofen-induced inhibition of platelet aggregation in healthy subjects.
Topics: Administration, Oral; Adult; Arachidonic Acid; Aspirin; Collagen; Cross-Over Studies; Cyclooxygenase Inhibitors; Half-Life; Humans; Ibuprofen; Middle Aged; Models, Biological; Monte Carlo Method; Platelet Aggregation; Platelet Aggregation Inhibitors; Single-Blind Method; Time Factors | 2008 |
Prevalence of platelet nonresponsiveness to aspirin in patients treated for secondary stroke prophylaxis and in patients with recurrent ischemic events.
Topics: Age Factors; Aged; Anti-Inflammatory Agents; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Artery Disease; Dipyridamole; Drug Therapy, Combination; Female; Humans; Ischemic Attack, Transient; Male; Odds Ratio; Platelet Aggregation; Recurrence; Stroke; Ticlopidine; Time Factors; Treatment Failure | 2008 |
Increased platelet sensitivity among individuals with aspirin resistance - platelet aggregation to submaximal concentration of arachidonic acid predicts response to antiplatelet therapy.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Receptors, Thromboxane; Reference Values; Thromboxane B2; Treatment Failure | 2008 |
Monitoring aspirin therapy with the Platelet Function Analyzer-100.
Topics: Adult; Arachidonic Acid; Aspirin; Coronary Artery Disease; Female; Health; Humans; Male; Middle Aged; Monitoring, Physiologic; Platelet Aggregation; Platelet Function Tests | 2008 |
Effects of aspirin and clopidogrel in healthy men measured by platelet aggregation and PFA-100.
Topics: Adenosine Diphosphate; Adolescent; Adult; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Epinephrine; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reference Values; Ticlopidine | 2008 |
Effect of increased aspirin dose after stenting in association with ClOpidogrel: the FIASCO randomized study.
Topics: Adenosine Diphosphate; Aged; Angina Pectoris; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Thrombotic events in high risk patients are predicted by evaluating different pathways of platelet function.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Likelihood Functions; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Prospective Studies; Reproducibility of Results; Risk Assessment; Risk Factors; ROC Curve; Thrombosis; Ticlopidine | 2008 |
Low molecular weight heparin significantly reduces embolisation after carotid endarterectomy--a randomised controlled trial.
Topics: Adenosine Diphosphate; Aged; Anticoagulants; Arachidonic Acid; Aspirin; Carotid Artery Diseases; Dalteparin; Double-Blind Method; Drug Therapy, Combination; Endarterectomy, Carotid; Female; Hemorrhage; Heparin; Humans; Infusions, Intravenous; Intracranial Embolism; Male; Middle Aged; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Assessment; Stroke; Time Factors; Treatment Outcome; Ultrasonography, Doppler, Transcranial | 2009 |
Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin.
Topics: Administration, Oral; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Resistance; Female; Gene Frequency; Haplotypes; Heterozygote; Homozygote; Humans; Italy; Male; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Young Adult | 2009 |
Cross validation of aspirin effect in healthy individuals by Impact-R and PFA-100: a double blind randomized placebo controlled trial.
Topics: Adult; Arachidonic Acid; Aspirin; Cell Adhesion; Double-Blind Method; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reference Values; Young Adult | 2009 |
Cross validation of the Multiple Electrode Aggregometry. A prospective trial in healthy volunteers.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Arachidonic Acid; Aspirin; Clopidogrel; Electrodes; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine; Time Factors; Young Adult | 2009 |
Pantoprazole may enhance antiplatelet effect of enteric-coated aspirin in patients with acute coronary syndrome.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Coronary Angiography; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Stents; Tablets, Enteric-Coated; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Platelet hyporesponsiveness to acetylsalicylic acid can be transferred by plasma in humans.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Drug Resistance; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests | 2010 |
Validation of a procedure to assess ASA-response in patients with decreased, initial TRAP induced aggregation.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Electric Impedance; Humans; Oligopeptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies | 2010 |
Variability and persistence of aspirin response in lower extremity peripheral arterial disease patients.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon; Arachidonic Acid; Aspirin; Azetidines; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Ezetimibe; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Lower Extremity; Male; Middle Aged; Niacin; Peripheral Arterial Disease; Placebo Effect; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Stents; Time Factors; Treatment Outcome | 2011 |
Low-dose naproxen interferes with the antiplatelet effects of aspirin in healthy subjects: recommendations to minimize the functional consequences.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Naproxen; Platelet Aggregation Inhibitors; Platelet-Rich Plasma; Reference Values; Thromboxane B2; Young Adult | 2011 |
Platelet function assessed by whole-blood aggregometry in patients undergoing non-cardiac surgery.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Double-Blind Method; Electric Impedance; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Preoperative Care; Prospective Studies; Secondary Prevention; Surgical Procedures, Operative; Time Factors | 2011 |
Effect of polymorphism and type II diabetes on aspirin resistance in patients with unstable coronary artery disease.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Genotype; Humans; Male; Membrane Glycoproteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIb-IX Complex; Polymerase Chain Reaction; Polymorphism, Genetic; Receptors, Purinergic P2Y1; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane B2 | 2011 |
Reversal of the anti-platelet effects of aspirin and clopidogrel.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Biomarkers; Blood Platelets; Clopidogrel; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Ontario; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Transfusion; Recovery of Function; Thromboxane B2; Ticlopidine; Time Factors | 2012 |
Aspirin response variability after major orthopedic surgery.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Aspirin; Blood Platelets; Cohort Studies; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; Thromboxane B2 | 2012 |
The in vitro effects of verbascoside on human platelet aggregation.
Topics: Adenosine Diphosphate; Adult; Aged; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Coronary Disease; Female; Glucosides; Humans; Male; Middle Aged; Phenols; Platelet Aggregation | 2012 |
Biological efficacy of twice daily aspirin in type 2 diabetic patients with coronary artery disease.
Topics: Analysis of Variance; Arachidonic Acid; Aspirin; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Administration Schedule; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2012 |
Aspirin attenuates platelet activation and immune activation in HIV-1-infected subjects on antiretroviral therapy: a pilot study.
Topics: Adenosine Diphosphate; Adult; Aged; Anti-HIV Agents; Arachidonic Acid; Aspirin; Cells, Cultured; Collagen; Female; HIV Infections; HIV-1; Humans; Inflammation; Lymphocyte Activation; Male; Middle Aged; P-Selectin; Pilot Projects; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxanes; Young Adult | 2013 |
Homocysteine is a novel risk factor for suboptimal response of blood platelets to acetylsalicylic acid in coronary artery disease: a randomized multicenter study.
Topics: Adult; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Coronary Artery Disease; Diabetes Mellitus, Type 2; Drug Resistance; Female; Homocysteine; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Young Adult | 2013 |
Platelet aggregation in rhesus macaques (Macaca mulatta) in response to short-term meloxicam administration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Humans; Macaca mulatta; Male; Meloxicam; Pain, Postoperative; Platelet Aggregation; Species Specificity; Thiazines; Thiazoles | 2013 |
Platelet function monitoring guided antiplatelet therapy in patients receiving high-risk coronary interventions.
Topics: Acute Coronary Syndrome; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors | 2014 |
Temporal variability in the antiplatelet effects of clopidogrel and aspirin after elective drug-eluting stent implantation. An ADAPT-DES substudy.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Elective Surgical Procedures; Female; Germany; Humans; Male; Middle Aged; Observer Variation; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Purinergic P2Y12; Ticlopidine | 2015 |
Effect of Vorapaxar Alone and in Combination with Aspirin on Bleeding Time and Platelet Aggregation in Healthy Adult Subjects.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Bleeding Time; Blood Coagulation Tests; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Lactones; Male; Middle Aged; Platelet Aggregation; Pyridines; Receptors, Thrombin; Young Adult | 2016 |
A randomised controlled trial comparing a dietary antiplatelet, the water-soluble tomato extract Fruitflow, with 75 mg aspirin in healthy subjects.
Topics: Aged; Arachidonic Acid; Aspirin; Blood Platelets; Cross-Over Studies; Diet; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Plant Extracts; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Solanum lycopersicum; Thromboxane B2 | 2017 |
Celecoxib use and circulating oxylipins in a colon polyp prevention trial.
Topics: Adenomatous Polyps; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Pressure; Celecoxib; Colon; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Humans; Male; Middle Aged; Oxylipins; Placebo Effect; Polyps; Selenium | 2018 |
Metamizole inhibits arachidonic acid-induced platelet aggregation after surgery and impairs the effect of aspirin in hospitalized patients.
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Dipyrone; Elective Surgical Procedures; Female; Hospitalization; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Period; Young Adult | 2019 |
The effect of metoprolol and aspirin on cardiovascular risk in bereavement: A randomized controlled trial.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Arachidonic Acid; Aspirin; Bereavement; Blood Platelets; Cardiovascular Diseases; Depression; Double-Blind Method; Female; Heart Rate; Humans; Male; Medication Therapy Management; Metoprolol; Middle Aged; Placebos; Prospective Studies; Systole | 2020 |
Differential Effects of Clopidogrel With or Without Aspirin on Platelet Reactivity and Coagulation Activation: A Randomized Trial in Healthy Volunteers.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; beta-Thromboglobulin; Blood Coagulation; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Drug Therapy, Combination; Healthy Volunteers; Humans; Male; Microfilament Proteins; P-Selectin; Phosphoproteins; Platelet Aggregation Inhibitors; Thromboxane B2; Whole Blood Coagulation Time; Young Adult | 2021 |
Pharmacodynamic Comparison of Ticagrelor Monotherapy Versus Ticagrelor and Aspirin in Patients After Percutaneous Coronary Intervention: The TEMPLATE (Ticagrelor Monotherapy and Platelet Reactivity) Randomized Controlled Trial.
Topics: Acute Coronary Syndrome; Aged; Arachidonic Acid; Aspirin; Drug Therapy, Combination; Dual Anti-Platelet Therapy; Female; Humans; Male; Middle Aged; Peptide Fragments; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Thromboxane A2, Prostaglandin H2; Ticagrelor | 2020 |
Aspirin and omega-3 fatty acid status interact in the prevention of cardiovascular diseases in Framingham Heart Study.
Topics: Aged; Arachidonic Acid; Aspirin; Cardiovascular Diseases; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Female; Humans; Longitudinal Studies; Male; Middle Aged; Treatment Outcome | 2021 |
Platelet inhibition by low-dose aspirin is not influenced by body mass or weight.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Body Weight; Collagen; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests | 2022 |
651 other study(ies) available for aspirin and arachidonic acid
| Article | Year |
|---|---|
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.
Topics: Animals; Biological Assay; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Isoenzymes; Kinetics; Placenta; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sheep | 1998 |
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
Topics: Acrolein; Alkaloids; Animals; Anthraquinones; Aspirin; Biological Assay; Catalysis; Cinnamomum zeylanicum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eugenol; Flavonoids; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Lactones; Models, Molecular; Nitrobenzenes; Oleanolic Acid; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Pyrogallol; Steroids; Sulfonamides; Sulfones; Syzygium; Terpenes; Triterpenes; Ursolic Acid | 2002 |
Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: identification of a lead for anti-inflammatory drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chromones; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Indoles; Mice; Models, Molecular; Molecular Structure; Pain; Pain Measurement; Pyrazoles; Structure-Activity Relationship | 2014 |
Collagen synthesis and prostaglandin inhibition in burns.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Burns; Collagen; Dinoprostone; Indomethacin; Rats; Rats, Inbred Strains | 1978 |
Inhibitory effect of aryl thienyl-ketones and -thioketones on arachidonic acid-induced malondialdehyde formation in human platelets: biological data and molecular modelling.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Crystallography, X-Ray; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Ketones; Kinetics; Malondialdehyde; Models, Molecular; Molecular Structure; Sulfhydryl Compounds | 1992 |
Evidence for, and taxonomic value of, an arachidonic acid cascade in the Lipomycetaceae.
Topics: Arachidonic Acid; Aspirin; Fatty Acids; Humans; Karyotyping; Lipoxygenase Inhibitors; Phenotype; Phylogeny; Prostaglandin-Endoperoxide Synthases; Saccharomycetales | 1992 |
Altered regulation of arachidonic acid metabolism by SV40 immortalized human urothelial cells.
Topics: Arachidonic Acid; Aspirin; Bradykinin; Calcimycin; Cell Line, Transformed; Dinoprostone; Diterpenes; Microsomes; Prostaglandin-Endoperoxide Synthases; Simian virus 40; Terpenes; Tetradecanoylphorbol Acetate; Urinary Bladder | 1992 |
Arachidonic acid metabolism in monocytes of aspirin-sensitive asthmatic patients before and after oral aspirin challenge.
Topics: Administration, Oral; Adult; Arachidonic Acid; Aspirin; Asthma; Bronchial Spasm; Calcimycin; Eicosanoids; Female; Humans; Leukotriene B4; Male; Middle Aged; Monocytes; Thromboxane B2 | 1992 |
Effects of a 5-lipoxygenase inhibitor, AA861, on lipoxygenase metabolism and superoxide anion generation by human polymorphonuclear leukocytes--potentiation of superoxide anion generation by LTB4.
Topics: Anions; Arachidonate Lipoxygenases; Arachidonic Acid; Aspirin; Benzoquinones; Complement C5a; Humans; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Superoxides | 1992 |
Low concentrations of sodium azide specifically inhibit a thromboxane A2 pathway in human platelets.
Topics: Adenosine Diphosphate; Apyrase; Arachidonic Acid; Aspirin; Azides; Blood Platelets; Calcium; Collagen; Energy Metabolism; Enzyme Activation; Humans; Hydrogen-Ion Concentration; Myosin-Light-Chain Kinase; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Secretory Rate; Serotonin; Sodium Azide; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2 | 1992 |
Study of thromboxane and prostacyclin metabolism in an in vitro model of first-trimester human trophoblast.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Aspirin; Chorionic Villi; Epoprostenol; Female; Humans; Karyotyping; Pregnancy; Pregnancy Trimester, First; Thromboxane B2; Thromboxanes; Trophoblasts | 1992 |
Effects of low-dose aspirin and specific thromboxane synthetase inhibition on whole blood platelet aggregation and adenosine triphosphate secretion in healthy dogs.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Dogs; Electric Impedance; Female; Platelet Aggregation; Platelet Count; Pyridines; Thromboxane-A Synthase | 1992 |
Effects of cyclooxygenase inhibitors on ex vivo cysteinyl-leukotriene production by whole human blood allowed to clot spontaneously. Comparison to stimulated blood.
Topics: Adult; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Aspirin; Blood Coagulation; Calcimycin; Cyclooxygenase Inhibitors; Depression, Chemical; Dose-Response Relationship, Drug; Humans; Ibuprofen; Leukotrienes; Male; N-Formylmethionine Leucyl-Phenylalanine; Thromboxane B2 | 1992 |
The effect of acetylsalicylic acid on orthodontic tooth movement in the guinea pig.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Aspirin; Bone Remodeling; Bone Resorption; Bronchoconstriction; Dental Stress Analysis; Guinea Pigs; Maxilla; Prostaglandins; Regression Analysis; Tooth Movement Techniques | 1992 |
Presence of arachidonic acid-like substance(s) in Thevitia neriifolia.
Topics: Animals; Arachidonic Acid; Aspirin; Female; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Pakistan; Plants, Medicinal; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 1992 |
Effect of anethole dithiolthione on human platelet aggregation.
Topics: Adenosine Diphosphate; Adult; Anethole Trithione; Arachidonic Acid; Aspirin; Butylated Hydroxytoluene; Humans; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Radioimmunoassay; Thrombin; Thromboxane B2 | 1992 |
Relevance of vasoactive mediators for the blood pressure effects of intravenous arachidonic acid injection in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Aspirin; Blood Pressure; Cyproheptadine; Diterpenes; Ginkgolides; Imidazoles; Injections, Intravenous; Lactones; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sulfonamides; Thromboxane B2 | 1992 |
Effects of non-steroidal anti-inflammatory drugs on demineralized bone-induced bone formation.
Topics: Acetaminophen; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Bone Matrix; Flurbiprofen; Indomethacin; Male; Osteogenesis; Piroxicam; Rats | 1992 |
The effects of varying doses of aspirin on human platelet activation induced by PAF, collagen and arachidonic acid.
Topics: Adenosine Triphosphate; Adult; Arachidonic Acid; Aspirin; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Sex Factors | 1992 |
Effects of butylated hydroxyanisole on arachidonic acid and linoleic acid metabolism in relation to gastrointestinal cell proliferation in the rat.
Topics: Animals; Arachidonic Acid; Aspirin; Butylated Hydroxyanisole; Cell Division; Digestive System; Indomethacin; Linoleic Acid; Linoleic Acids; Lipoxygenase; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains | 1992 |
Effects of the new antiplatelet agent 2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine on platelet aggregation and thrombosis in experimental animals.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Bridged Bicyclo Compounds; Cyclooxygenase Inhibitors; Dogs; Electroencephalography; Female; Fibrinolytic Agents; Guinea Pigs; Humans; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred ICR; Nicotinic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Inbred Strains; Respiration; Stomach Ulcer | 1992 |
In vitro study of platelets and circulating mononuclear cells of subjects presenting an intolerance to aspirin.
Topics: Aged; Arachidonic Acid; Aspirin; Asthma; Blood Platelets; Drug Hypersensitivity; Female; Humans; In Vitro Techniques; Ketoprofen; Leukocytes, Mononuclear; Luminescent Measurements; Lymphocyte Activation; Male; Middle Aged; Salicylamides | 1992 |
Triflusal vs aspirin on the inhibition of human platelet and vascular cyclooxygenase.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Salicylates; Thromboxane B2 | 1992 |
Experimental carotid stenosis and endothelial injury in the rabbit: an in vivo model to study intravascular platelet aggregation.
Topics: Animals; Arachidonic Acid; Aspirin; Carotid Stenosis; Disease Models, Animal; Endothelium, Vascular; Female; Male; Pentanoic Acids; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Pyridines; Rabbits; Thromboxane-A Synthase | 1992 |
Characteristics and regulation of ganglioside-induced elevation of free cytoplasmic Ca2+ in human blood platelets.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Cytoplasm; Epinephrine; Fura-2; G(M3) Ganglioside; Gangliosides; Humans; Phospholipids; Up-Regulation | 1992 |
Amplification of LTB4 generation in AM-PMN cocultures: transcellular 5-lipoxygenase metabolism.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Aspirin; Cell Separation; Cells, Cultured; Cytological Techniques; Eicosanoids; Humans; Leukotriene B4; Macrophages; Neutrophils; Pulmonary Alveoli; Rabbits; Tritium | 1991 |
Effects of anti-inflammatory drugs on rat hind-paw swelling caused by phospholipase A2 from Naja naja atra venom.
Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Edema; Elapid Venoms; Histamine; Kinins; Leukocytes, Mononuclear; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Rats, Inbred Strains; Serotonin; Time Factors | 1991 |
Different effects of prostaglandins on adrenergic neurotransmission in atrial and ventricular preparations.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Dinoprostone; Electric Stimulation; Epoprostenol; Guinea Pigs; Heart; Heart Atria; Heart Ventricles; Iloprost; In Vitro Techniques; Indomethacin; Injections, Intraventricular; Prostaglandins; Sympathetic Nervous System; Synaptic Transmission | 1990 |
Regulation of prostaglandin H synthase activity in dog urothelial cells.
Topics: Alkaloids; Animals; Arachidonic Acid; Aspirin; Cells, Cultured; Cycloheximide; Dinoprostone; Dogs; Prostaglandin-Endoperoxide Synthases; Staurosporine; Tetradecanoylphorbol Acetate; Urinary Bladder | 1992 |
Asthma relieved by aspirin: clinical studies, platelet function, and arachidonate metabolism.
Topics: Arachidonic Acid; Aspirin; Asthma; Blood Platelets; Cyclooxygenase Inhibitors; Female; Humans; Middle Aged | 1992 |
Epidermal growth factor enhances a microsomal 12-lipoxygenase activity in A431 cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonate 12-Lipoxygenase; Arachidonic Acid; Aspirin; Caffeic Acids; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cycloheximide; Epidermal Growth Factor; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Mice; Microsomes; NADP; Stereoisomerism; Substrate Specificity; Tumor Cells, Cultured | 1992 |
Mediator release in aspirin-induced reactions.
Topics: Anaphylaxis; Arachidonic Acid; Aspirin; Asthma; Drug Hypersensitivity; Humans; Leukotrienes | 1991 |
Reversible effects of triamcinolone and lack of effects with aspirin or L-656,224 on external genitalia of male Sprague-Dawley rats exposed in utero.
Topics: Abnormalities, Drug-Induced; Animals; Arachidonic Acid; Aspirin; Benzofurans; Female; Fetal Death; Genitalia, Male; Gestational Age; Hypospadias; Male; Pregnancy; Rats; Rats, Inbred Strains; Triamcinolone; Weaning | 1991 |
Vitamin D3 stimulates the production of prostacyclin by vascular smooth muscle cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Aspirin; Calcitriol; Calcium; Cells, Cultured; Epoprostenol; Hydroxycholecalciferols; Male; Muscle, Smooth, Vascular; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Rabbits | 1991 |
Action of some salicylate derivatives on in vitro platelet aggregation. Inhibitory and inhibition antagonistic effects.
Topics: Arachidonic Acid; Aspirin; Humans; In Vitro Techniques; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Structure-Activity Relationship | 1991 |
Effects of combination therapy with low-dose aspirin and warfarin on platelet functions after heart valve replacement.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Bleeding Time; Blood Platelets; Calcium; Collagen; Drug Therapy, Combination; Female; Heart Valve Prosthesis; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prostaglandin Endoperoxides, Synthetic; Thromboembolism; Ticlopidine; Warfarin | 1991 |
Reverse phase HPLC profiling of arachidonic acid metabolites in blood stimulated ex vivo.
Topics: Anticoagulants; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Chromatography, High Pressure Liquid; Eicosanoids; Enzyme Activation; Humans; Prostaglandin-Endoperoxide Synthases; Prostaglandins B; Zymosan | 1991 |
Inhibitors of arachidonic acid metabolism: effects on rat striatal dopamine release and uptake.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Carrier Proteins; Corpus Striatum; Cyclooxygenase Inhibitors; Dopamine; Dopamine Plasma Membrane Transport Proteins; Estrenes; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Male; Masoprocol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nomifensine; Phospholipases A; Phospholipases A2; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2 | 1991 |
[Effect of antiplatelet therapy on prevention of thrombotic diseases].
Topics: Arachidonic Acid; Arterial Occlusive Diseases; Aspirin; Cerebral Infarction; Humans; Myocardial Infarction; Nucleotides, Cyclic; Platelet Aggregation Inhibitors; Receptors, Prostaglandin; Receptors, Thromboxane; Recurrence; Thrombosis | 1991 |
Induction of fatty acid cyclooxygenase in mouse osteoblastic cells (MC3T3-E1).
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Bucladesine; Cattle; Cell Line; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Induction; Epidermal Growth Factor; Epinephrine; Mice; Osteoblasts; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Second Messenger Systems; Transforming Growth Factor beta | 1991 |
Persistent effects of interleukin-1 on smooth muscle preparations from adrenalectomized rats: implications for increased phospholipase-A2 activity via stimulation of 5-lipoxygenase.
Topics: Adrenalectomy; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Aspirin; Chromatography, High Pressure Liquid; Chromones; Humans; Indomethacin; Interleukin-1; Leukotrienes; Lipoxygenase Inhibitors; Male; Masoprocol; Muscle Contraction; Muscle, Smooth; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Recombinant Proteins; SRS-A; Stimulation, Chemical; Stomach; Time Factors | 1991 |
Some properties of rat platelet aggregation and effects of butylated hydroxytoluene, warfarin and aspirin.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Coagulation Factors; Butylated Hydroxytoluene; Collagen; Epinephrine; Male; Platelet Activating Factor; Platelet Aggregation; Rats; Rats, Inbred Strains; Ristocetin; Warfarin | 1991 |
Isolation of a novel arachidonic acid metabolite 3-hydroxy-5,8,11,14-eicosatetraenoic acid (3-HETE) from the yeast Dipodascopsis uninucleata UOFs-Y128.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Hydroxyeicosatetraenoic Acids; Mass Spectrometry; Saccharomycetales; Spectrophotometry | 1991 |
Regeneration of vitamin E in human platelets.
Topics: Arachidonate 12-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Chromatography, High Pressure Liquid; Humans; Indomethacin; Kinetics; Oxidation-Reduction; Solubility; Vitamin E | 1991 |
Superoxide dismutase triggers activation of "primed" platelets.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Catalase; Collagen; Humans; Male; Platelet Activation; Platelet Aggregation; Serotonin; Superoxide Dismutase; Thromboxane A2 | 1991 |
Cyclooxygenase activity is increased in platelets from psoriatic patients.
Topics: Adult; Arachidonic Acid; Aspirin; Blood Platelets; Carbon Radioisotopes; Collagen; Humans; Kinetics; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Psoriasis; Thromboxane A2 | 1991 |
In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Drug Interactions; Female; Humans; Male; Malondialdehyde; Phthalic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Sulfonamides; Thromboxane B2 | 1991 |
Comparison of in vitro platelet aggregation and its inhibition by three antithrombotic drugs between human and guinea pig.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Collagen; Dipyridamole; Guinea Pigs; Humans; Pentoxifylline; Platelet Aggregation; Platelet Aggregation Inhibitors; Species Specificity; Thrombin | 1991 |
Aspirin-induced decline in prostacyclin production in patients with coronary artery disease is due to decreased endoperoxide shift. Analysis of the effects of a combination of aspirin and n-3 fatty acids on the eicosanoid profile.
Topics: Aged; Arachidonic Acid; Aspirin; Coronary Disease; Eicosanoids; Eicosapentaenoic Acid; Epoprostenol; Female; Fish Oils; Humans; Male; Middle Aged; Phospholipids; Prostaglandin Endoperoxides; Thromboxanes | 1991 |
Biochemical and pharmacological studies of the mechanism of action of tenebrosin-C, a cardiac stimulatory and haemolytic protein from the sea anemone, Actinia tenebrosa.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cardiotonic Agents; Cnidaria; Guinea Pigs; Hemolysis; Indomethacin; Invertebrate Hormones; Male; Myocardial Contraction; Peptide Hydrolases; Phospholipases A; Phospholipases A2; Sea Anemones | 1990 |
Glutathione disulfide production during arachidonic acid oxygenation in human platelets.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Glutathione; Glutathione Disulfide; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Thrombin; Thromboxane B2 | 1990 |
The combined effects of N-3 fatty acids and aspirin on hemostatic parameters in man.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Bleeding Time; Collagen; Depression, Chemical; Drug Synergism; Fish Oils; Hemostasis; Humans; Male; Platelet Activating Factor; Platelet Aggregation | 1990 |
Levamisole inhibits in vivo rat platelet aggregation by a release of prostacyclin-like factor.
Topics: Adenosine Diphosphate; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Epoprostenol; Half-Life; In Vitro Techniques; Leukocytes; Levamisole; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Thromboxane A2 | 1990 |
A new platelet function test.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Bleeding Time; Blood Specimen Collection; Calcium; Collagen; Edetic Acid; Humans; Platelet Aggregation; Platelet Count; Platelet Function Tests; Ristocetin | 1990 |
5-Hydroxytryptamine and arachidonic acid metabolites modulate extensive platelet activation induced by collagen in cats in vivo.
Topics: Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Cats; Collagen; Cyclooxygenase Inhibitors; Female; Ketanserin; Male; Muscle, Smooth, Vascular; Pentanoic Acids; Platelet Activation; Pyridines; Receptors, Prostaglandin; Serotonin; Thromboxane-A Synthase | 1990 |
Arachidonic acid and related methyl ester mediate protein kinase C activation in intact platelets through the arachidonate metabolism pathways.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cell-Free System; Enzyme Activation; Esters; In Vitro Techniques; Methylation; Phosphoproteins; Protein Kinase C; Rats; Structure-Activity Relationship | 1990 |
Aspirin--relieved asthma.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Drug Tolerance; Humans; Models, Biological; Prostaglandin-Endoperoxide Synthases; Prostaglandins | 1990 |
Effects of various inhibitors on platelet activation induced by TP 82, a CD 9 monoclonal antibody.
Topics: Adenosine Diphosphate; Aequorin; Amino Acid Sequence; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Dose-Response Relationship, Drug; Humans; Membrane Glycoproteins; Molecular Sequence Data; Oligopeptides; Platelet Activation; Serotonin; Tetraspanin 29; Thromboxane A2 | 1990 |
Gastric microvascular endothelium: a major target for aspirin-induced injury and arachidonic acid protection. An ultrastructural analysis in the rat.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Capillaries; Endothelium, Vascular; Fluorescent Antibody Technique; Gastric Mucosa; Immunohistochemistry; Male; Microscopy, Electron; Rats; Rats, Inbred Strains; Stomach Diseases; Time Factors; Vimentin | 1990 |
Arachidonic acid-induced calcium influx in human platelets. Comparison with the effect of thrombin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Biological Transport; Blood Platelets; Calcium; Carcinoma, Ehrlich Tumor; Egtazic Acid; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Fluoresceins; Fluorescent Dyes; Fura-2; Humans; In Vitro Techniques; Kinetics; Manganese; Masoprocol; Mice; Neutrophils; Prostaglandin Endoperoxides, Synthetic; Rats; Spectrometry, Fluorescence; Structure-Activity Relationship; T-Lymphocytes; Thrombin | 1990 |
In vitro inhibitors of prostaglandin synthesis: (p-thiosubstituted)-benzyl nitrogen heterocycles.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Aspirin; Benzyl Compounds; Blood Platelets; Chemical Phenomena; Chemistry, Physical; Heterocyclic Compounds; Humans; In Vitro Techniques; Malondialdehyde; Prostaglandin Antagonists; Sulfhydryl Compounds; Sulfides | 1990 |
The effects of inhibitors of arachidonate metabolism on spontaneous and evoked endplate potentials at normal and crotoxin-treated frog neuromuscular junctions.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Crotoxin; Evoked Potentials; In Vitro Techniques; Masoprocol; Motor Endplate; Neuromuscular Junction; Rana temporaria | 1990 |
Studies on 1,2,3-triazole derivatives as in vitro inhibitors of prostaglandin synthesis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Humans; In Vitro Techniques; Indomethacin; Malondialdehyde; Prostaglandin Antagonists; Triazoles | 1990 |
Aspirin, prostaglandin E1 and Quin-2 AM-induced platelet dysfunction: restoration of function by noradrenalin.
Topics: Adult; Alprostadil; Aminoquinolines; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcium; Cell Membrane; Humans; Norepinephrine; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Adrenergic, alpha; Yohimbine | 1990 |
Studies on the release of leukotrienes and histamine by human lung parenchymal and bronchial fragments upon immunologic and nonimmunologic stimulation. Effects of nordihydroguaiaretic acid, aspirin, and sodium cromoglycate.
Topics: Adjuvants, Immunologic; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Aspirin; Bronchi; Catechols; Cromolyn Sodium; Histamine Release; Humans; Kinetics; Leukotriene B4; Lipoxygenase; Lipoxygenase Inhibitors; Lung; Masoprocol; SRS-A | 1985 |
[Clinical and pathogenetic aspects of aspirin intolerance].
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Complement Activation; Drug Eruptions; Histamine Release; Humans; Prostaglandin Antagonists | 1986 |
Abnormal responses to aspirin of leukocyte oxygenation of arachidonic acid in adults with aspirin intolerance.
Topics: Adult; Aged; Antibodies, Anti-Idiotypic; Arachidonic Acid; Arachidonic Acids; Aspirin; Basophils; Drug Hypersensitivity; Female; Histamine Release; Humans; Immunoglobulin E; Leukocytes; Male; Middle Aged; Oxygen | 1986 |
Mechanism of inhibitory action of tranilast on the release of slow reacting substance of anaphylaxis (SRS-A) in vitro: effect of tranilast on the release of arachidonic acid and its metabolites.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Histamine; Humans; In Vitro Techniques; Leukocytes; Male; Mice; ortho-Aminobenzoates; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Inbred Strains; SRS-A | 1988 |
High concentrations of exogenous arachidonate inhibit calcium mobilization in platelets by stimulation of adenylate cyclase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenylyl Cyclases; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcium; Cyclic AMP; Deoxyadenosines; Dideoxyadenosine; Enzyme Induction; Epoprostenol; Humans; Iloprost; In Vitro Techniques; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Pyrazoles; Thromboxane B2 | 1988 |
Evidence for a bidirectional prostaglandin endoperoxide shunt between platelets and the bovine coronary artery.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cattle; Coronary Vessels; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Epoprostenol; Humans; Imidazoles; Intramolecular Oxidoreductases; Isomerases; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Pyridines; Thromboxane B2; Thromboxane-A Synthase | 1989 |
Iron chelators inhibit human platelet aggregation, thromboxane A2 synthesis and lipoxygenase activity.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Deferiprone; Deferoxamine; Epinephrine; Humans; Iron; Iron Chelating Agents; Lipoxygenase; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyridones; Thromboxane A2 | 1989 |
Effects of acetylsalicylic acid on the phagocytic function of human polymorphonuclear leukocytes in vitro.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Candida albicans; Cell Movement; Humans; In Vitro Techniques; Leukocyte Adherence Inhibition Test; Neutrophils; Nitroblue Tetrazolium; Phagocytosis | 1989 |
Contraction of the rat isolated aorta caused by Clostridium perfringens alpha toxin (phospholipase C): evidence for the involvement of arachidonic acid metabolism.
Topics: Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Bacterial Toxins; Calcium-Binding Proteins; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Male; Methacrylates; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Thromboxane B2; Thromboxane-A Synthase; Type C Phospholipases | 1989 |
Optical spectra and kinetics of reactions of prostaglandin H synthase: effects of the substrates 13-hydroperoxyoctadeca-9,11-dienoic acid, arachidonic acid, N,N,N',N'-tetramethyl-p-phenylenediamine, and phenol and of the nonsteroidal anti-inflammatory dru
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Benzophenones; Bromobenzenes; Indomethacin; Kinetics; Linoleic Acids; Lipid Peroxides; Male; Phenol; Phenols; Phenylbutazone; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep; Spectrophotometry; Tetramethylphenylenediamine | 1989 |
[Platelet aggregation in asthma].
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Bronchial Provocation Tests; Collagen; Drug Hypersensitivity; Epinephrine; Humans; Platelet Aggregation | 1989 |
Prostaglandins in carotid sinus enhance baroreflex in rabbits.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Pressure; Carotid Sinus; Epoprostenol; Female; In Vitro Techniques; Indomethacin; Male; Pressoreceptors; Rabbits; Reference Values; Reflex | 1989 |
Attenuation of reactive hyperemia caused by aspirin in canine coronary artery.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Coronary Circulation; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Hyperemia | 1989 |
[Effects of low-dose acetylsalicylic acid on thrombocytes in health subjects and in patients with coronary heart disease].
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Coronary Disease; Dose-Response Relationship, Drug; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Thromboxane B2; Time Factors | 1989 |
Cooperation of adipocytes and endothelial cells required for catecholamine stimulation of PGI2 production by rat adipose tissue.
Topics: 6-Ketoprostaglandin F1 alpha; Adipose Tissue; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Catecholamines; Cell Communication; Cell Separation; Dose-Response Relationship, Drug; Endothelium, Vascular; Epinephrine; Epoprostenol; Lipolysis; Male; Rats; Rats, Inbred Strains | 1989 |
Abnormality in prostacyclin-stimulatory activity in sera from diabetics.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cells, Cultured; Chromatography, Gel; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dialysis; Endothelium, Vascular; Epoprostenol; Humans; Male; Rats; Rats, Inbred Strains | 1989 |
Etiology of nasal polyps associated with aspirin-sensitive asthma.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Cytoplasmic Granules; Drug Hypersensitivity; Eosinophils; Humans; Leukotrienes; Mast Cells; Microscopy, Electron; Nasal Mucosa; Nasal Polyps; Prostaglandins | 1989 |
Stimulation of 12-HETE production in human platelets by an immunomodulator, LF 1695. Evidence for activation of arachidonate liberation coupled to cyclo-oxygenase inhibition.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Adjuvants, Immunologic; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcimycin; Cyclooxygenase Inhibitors; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin | 1989 |
Regulation of prostaglandin H synthase mRNA levels and prostaglandin biosynthesis by platelet-derived growth factor.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Cell Line; Cycloheximide; Dinoprostone; Gene Expression Regulation; Kinetics; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Protein Biosynthesis; Recombinant Proteins; RNA, Messenger | 1989 |
Oxidant-mediated activation of phospholipase A2 in pulmonary endothelium.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Calcium Channel Blockers; Cattle; Cells, Cultured; Cycloheximide; Dactinomycin; Dexamethasone; Dinoprostone; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Kinetics; Peroxides; Phospholipases; Phospholipases A; Phospholipases A2; Prostaglandin D2; Pulmonary Artery; tert-Butylhydroperoxide; Thromboxane B2; Vitamin E | 1989 |
Increased platelet aggregation and intracellular calcium in hypertensive patients: effects of cyclo-oxygenase blockade.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcium; Cyclooxygenase Inhibitors; Female; Humans; Hypertension; Male; Middle Aged; Platelet Aggregation; Thromboxane A2 | 1989 |
Prostacyclin as a potent effector of adipose-cell differentiation.
Topics: Adipose Tissue; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cell Differentiation; Cell Line; Cyclic AMP; Epoprostenol; Humans; Indomethacin; Mice; Mitosis; Prostaglandins F; Prostaglandins, Synthetic; Rats | 1989 |
Modulation of resynthesis of 1-alkyl-2-arachidonyl-glycero-3-phosphocholine and phosphatidylinositols for interception in vivo of free arachidonic acid, lyso-PAF, diacyl-glycerols, and phosphoinositides.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Burns; Diglycerides; Disease Models, Animal; Flavonoids; Ginkgo biloba; Hemostatics; Humans; Lysophosphatidylcholines; Pain; Pain Measurement; Phosphatidylinositols; Plant Extracts; Platelet Activating Factor; Swine | 1989 |
Platelet aggregation in the Asian elephant is not dependent on thromboxane B2 production.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Elephants; Female; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Verapamil | 1989 |
Arachidonic acid and LTB4 enhance aggregation of psoriatic peripheral blood mononuclear leukocytes in vitro.
Topics: Adult; Aged; Arachidonic Acid; Arachidonic Acids; Aspirin; Cell Aggregation; Female; Humans; In Vitro Techniques; Indomethacin; Leukotriene B4; Male; Masoprocol; Middle Aged; Monocytes; Psoriasis | 1987 |
Effect of effervescent buffered aspirin on prostaglandin synthesis by human gingival fibroblasts.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Bicarbonates; Buffers; Cells, Cultured; Citrates; Citric Acid; Fibroblasts; Gingiva; Humans; Prostaglandins; Sodium; Sodium Bicarbonate | 1987 |
Shortened megakaryocyte-platelet regeneration time in young survivors of myocardial infarction.
Topics: Adrenergic beta-Antagonists; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cell Survival; Fatty Acids, Unsaturated; Female; Humans; Male; Megakaryocytes; Myocardial Infarction; Prostaglandin-Endoperoxide Synthases; Risk | 1985 |
Lymphocyte aggregation in response to adrenergic stimulation.
Topics: Adenosine Diphosphate; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Cell Aggregation; Citrates; Citric Acid; Dyspnea; Female; Humans; Leukapheresis; Leukemia, Lymphoid; Lymphocytes; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Receptors, Adrenergic, beta | 1988 |
Phospholipase C from clostridium perfringens induces human platelet aggregation in plasma.
Topics: Adenosine Diphosphate; Adult; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Clostridium perfringens; Female; Humans; In Vitro Techniques; Male; Platelet Aggregation; Type C Phospholipases | 1988 |
Effects of inhibition of thromboxane A2 synthesis in aspirin-induced asthma.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Drug Hypersensitivity; Female; Humans; Male; Methacrylates; Middle Aged; Platelet Aggregation; Thromboxane-A Synthase | 1987 |
Inhibition by corticosteroids of epidermal growth factor-induced recovery of cyclooxygenase after aspirin inactivation.
Topics: Adrenal Cortex Hormones; Animals; Annexins; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Cells, Cultured; Cycloheximide; Cyclooxygenase Inhibitors; Dactinomycin; Dexamethasone; Enzyme Activation; Epidermal Growth Factor; Epoprostenol; Glycoproteins; Kinetics; Male; Muscle, Smooth, Vascular; Peptides; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Transforming Growth Factors | 1988 |
Intolerance to aspirin and the nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Drug Hypersensitivity; Drug Tolerance; Humans; Hydroxyeicosatetraenoic Acids; Leukocytes; Leukotriene B4; Leukotrienes; Lipoxygenase; Prostaglandin-Endoperoxide Synthases; SRS-A | 1985 |
High concentrations of arachidonic acid induce platelet aggregation and serotonin release independent of prostaglandin endoperoxides and thromboxane A2.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Albumins; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Bucladesine; Culture Media; Diglycerides; Dose-Response Relationship, Drug; Edetic Acid; Fatty Acids; Fatty Acids, Unsaturated; Humans; Molecular Weight; Phosphatidic Acids; Phosphocreatine; Phosphorylation; Platelet Aggregation; Prostaglandin Endoperoxides; Secretory Rate; Serotonin; Thromboxane A2 | 1985 |
Effects of arachidonic acid on the metabolism of eicosapentaenoic acid in washed human platelets.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Carbon Radioisotopes; Eicosapentaenoic Acid; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Kinetics; Prostaglandins G | 1985 |
Gentisic acid: an aspirin metabolite with multiple effects on human blood polymorphonuclear leukocytes.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Cell Aggregation; Depression, Chemical; Fluorescence Polarization; Gentisates; Humans; Hydroxybenzoates; Membrane Fluidity; Neutrophils; Superoxides | 1986 |
Effects of inhibitors of arachidonic acid metabolism on intercellular adhesion of SV40-3T3 cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Catechols; Cell Aggregation; Cell Transformation, Viral; Cells, Cultured; Cyclooxygenase Inhibitors; Indomethacin; Masoprocol; Mice; Quinacrine; Simian virus 40 | 1986 |
Identification of distinct activation pathways of the human neutrophil NADPH-oxidase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Enzyme Activation; Humans; Indomethacin; Isoquinolines; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Piperazines; Pyrazoles; Quinacrine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1986 |
Increase of cyclic AMP concentrations in cultured vascular smooth muscle cells by vasoactive peptide hormones. Role of endogenous prostaglandins.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Angiotensin II; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Cells, Cultured; Cyclic AMP; Deamino Arginine Vasopressin; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Muscle, Smooth, Vascular; Prostaglandins; Prostaglandins E; Time Factors; Vasoconstriction; Vasopressins | 1986 |
Inhibition of platelet thromboxane generation by suloctidil in man.
Topics: Adult; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Dinoprostone; Drug Interactions; Epoprostenol; Female; Humans; In Vitro Techniques; Kinetics; Male; Muscle, Smooth; Propanolamines; Prostaglandins E; Rats; Suloctidil; Thromboxane A2; Thromboxane B2 | 1986 |
Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Carrier Proteins; Enzyme Activation; Epinephrine; Fibrinogen; Humans; Hydrogen-Ion Concentration; Phospholipases; Phospholipases A; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Sodium-Hydrogen Exchangers; Thromboxane A2; Type C Phospholipases | 1986 |
Eicosanoids and aspirin in immune cell function.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Eicosanoic Acids; Humans; Lymphocyte Activation; Lymphocytes; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipases; Protein Kinase C | 1985 |
Metabolism of arachidonic acid in human lung cancer cell lines.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Carcinoma, Small Cell; Cell Line; Dinoprostone; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Mitoxantrone; Prostaglandins E; Time Factors | 1987 |
Altered renal and platelet arachidonic acid metabolism in cirrhosis.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Kidney Injury; Adult; Aged; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Creatinine; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Epoprostenol; Female; Humans; Kidney; Liver Cirrhosis; Male; Middle Aged; Natriuresis; Prostaglandins E; Prostaglandins F; Renin-Angiotensin System; Sulindac; Thromboxane A2; Thromboxane B2 | 1986 |
A secondary isotope effect in the lipoxygenase reaction.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Chromatography, High Pressure Liquid; Humans; Hydroxyeicosatetraenoic Acids; Isotope Labeling; Lipoxygenase; Mathematics | 1986 |
Pathways responsible for platelet hypersensitivity in rats with diabetes. I. Streptozocin-induced diabetes.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Creatine Kinase; Diabetes Mellitus; In Vitro Techniques; Male; Phosphocreatine; Platelet Adhesiveness; Platelet Aggregation; Rats; Rats, Inbred Strains; Serotonin; Thrombin | 1986 |
Effect of aspirin and sulindac in rabbit nephrotoxic nephritis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Basement Membrane; Blood Platelets; Cyclooxygenase Inhibitors; Indenes; Kidney Glomerulus; Male; Nephritis; Prostaglandins; Rabbits; Sulindac; Thromboxanes | 1986 |
The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation in man and the rat.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Creatine Kinase; Dose-Response Relationship, Drug; Humans; Imidazoles; In Vitro Techniques; Male; Phosphocreatine; Platelet Aggregation; Prostaglandin Endoperoxides; Rats; Rats, Inbred Strains; Species Specificity; Thromboxane A2; Thromboxane B2 | 1986 |
Lowered glutathione-peroxidase activity in asthmatic patients with food and aspirin intolerance.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Blood Platelets; Cyclooxygenase Inhibitors; Drug Hypersensitivity; Food Hypersensitivity; Free Radicals; Glutathione Peroxidase; Prostaglandin-Endoperoxide Synthases; Selenium | 1986 |
The effect of tetradecanoylphorbol acetate on calcium-ion mobilization, protein phosphorylation and cytoskeletal assembly induced by thrombin or arachidonate.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcium; Cytoskeleton; Ethers; Humans; Ionomycin; Myosins; Phorbols; Phosphorylation; Platelet Aggregation; Protein Kinase C; Serotonin; Tetradecanoylphorbol Acetate; Thrombin | 1986 |
Relationship between structure and activity of aspirin-related compounds on the inhibition of in vitro platelet aggregation.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Drug Interactions; Humans; In Vitro Techniques; Platelet Aggregation; Salicylates; Structure-Activity Relationship | 1986 |
The arachidonic acid cascade is involved in the masculinizing action of testosterone on embryonic external genitalia in mice.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cortisone; Cyproterone; Estradiol; Female; Genitalia, Female; Genitalia, Male; Indomethacin; Male; Mice; Morphogenesis; Phenytoin; Testosterone | 1986 |
Prostacyclin and steroidogenesis in goat ovarian cell types in vitro.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Dipyridamole; Epoprostenol; Estradiol; Female; Goats; In Vitro Techniques; Indomethacin; Ovary; Progesterone; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Steroids; Trapidil | 1986 |
Effects of acetylsalicylic acid on platelet aggregation in male and female whole blood: an in vitro study.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Male; Platelet Aggregation; Sex Factors | 1986 |
Miconazole inhibition of platelet aggregation by inhibiting cyclooxygenase.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Cyclooxygenase Inhibitors; Humans; Kinetics; Malondialdehyde; Miconazole; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases | 1986 |
Platelet aggregating substance from mononuclear leukocytes.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Coagulation Factors; Catechols; Humans; In Vitro Techniques; Masoprocol; Monocytes; Platelet Activating Factor; Platelet Aggregation | 1986 |
Enhancement of mononuclear procoagulant activity by platelet 12-hydroxyeicosatetraenoic acid.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Coagulation Factors; Blood Platelets; Cyclooxygenase Inhibitors; Endotoxins; Humans; Hydroxyeicosatetraenoic Acids; Leukocytes; Thromboplastin | 1986 |
Dazoxiben, UK 38,485 and aspirin: duration of effect for preventing thrombotic sudden death in rabbits.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Imidazoles; Male; Rabbits; Thrombocytopenia; Thrombosis; Thromboxane B2; Time Factors | 1986 |
Trial of repeated low-dose aspirin in diabetic angiopathy.
Topics: Adenosine Triphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Diabetes Mellitus; Diabetic Angiopathies; Drug Administration Schedule; Female; Humans; Male; Malondialdehyde; Middle Aged; Platelet Aggregation; Thromboxane B2 | 1986 |
ATP-secretion occurs as an initial response in collagen induced platelet activation.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Edetic Acid; Egtazic Acid; Humans; Kinetics; Platelet Aggregation; Theophylline; Verapamil; Yohimbine | 1986 |
Effect of cilostazol on experimental cerebral infarction in rabbits.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Azoles; Brain; Cerebral Infarction; Cilostazol; Injections, Intravenous; Piperidines; Rabbits; Tetrazoles; Vasodilator Agents | 1986 |
Pharmacological modulation of the effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine in guinea-pigs: involvement of the arachidonic acid cascade.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Cell Count; Blood Platelets; Bronchi; Female; Guinea Pigs; Indomethacin; Lung; Male; Microscopy, Electron; N-Formylmethionine Leucyl-Phenylalanine; Pyrazoles; Thromboxane B2 | 1986 |
Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Pressure; Dexamethasone; Gastric Mucosa; Hematocrit; Male; Necrosis; Platelet Activating Factor; Prednisolone; Pyrazoles; Rats; Rats, Inbred Strains | 1986 |
Salicylate antagonism of acetylsalicylic acid inhibition of platelet aggregation in male and female subjects: influence of citrate concentration.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Citrates; Citric Acid; Collagen; Female; Humans; In Vitro Techniques; Male; Middle Aged; Platelet Aggregation; Sex Factors; Sodium Salicylate | 1986 |
Determination of platelet-megakaryocyte regeneration time in painters occupationally exposed to organic solvents.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Chromatography, High Pressure Liquid; Fatty Acids, Unsaturated; Humans; Male; Megakaryocytes; Middle Aged; Occupational Diseases; Paint; Solvents; Spectrophotometry, Ultraviolet | 1986 |
Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man.
Topics: Adenosine Diphosphate; Adolescent; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Thromboxane B2; Thromboxanes | 1986 |
Platelets and prostaglandins.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Humans; Migraine Disorders; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Thromboxanes | 1986 |
Arachidonic acid metabolites during nasal challenge.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Female; Histamine; Humans; Male; Nasal Provocation Tests; Peptide Hydrolases; Premedication; Prostaglandin D2; Prostaglandins D; Prostaglandins E; Rhinitis, Allergic, Seasonal; Sneezing; SRS-A; Thromboxanes | 1987 |
Effects of a new anti-inflammatory imidazole derivative, fenflumizole, on platelet aggregation in the rabbit.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Imidazoles; In Vitro Techniques; Male; Platelet Aggregation; Rabbits | 1986 |
Stimulation of prostaglandin production by (2E,6Z,10E)-7-hydroxymethyl-3,11,15-trimethyl-2,6,10,14-++ +hexadecatetrae n-1-ol (plaunotol), a new anti-ulcer drug, in vitro and in vivo.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Dinoprostone; Diterpenes; Epoprostenol; Fatty Alcohols; Fibroblasts; Gastric Mucosa; Mice; Phospholipases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostaglandins E; Rats | 1987 |
Differential effects of aspirin and dexamethasone on phospholipase A2 and C activities and arachidonic acid release from endothelial cells in response to bradykinin and leukotriene D4.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Bradykinin; Cattle; Cell Line; Dexamethasone; Endothelium; Phospholipases A; Phospholipases A2; SRS-A; Type C Phospholipases | 1986 |
Macrophage eicosanoid formation is stimulated by platelet arachidonic acid and prostaglandin endoperoxide transfer.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Female; Macrophages; Male; Prostaglandin Endoperoxides; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1987 |
Prostaglandins in the semicircular canal of the frog.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Dinoprostone; Epoprostenol; In Vitro Techniques; Indomethacin; Potassium; Prostaglandins E; Rana esculenta; Semicircular Canals; Sodium; Streptomycin | 1987 |
Protective effect of triflusal and acetylsalicylic acid against arachidonic acid induced cerebrovascular occlusion in anesthetized rats.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cerebrovascular Disorders; Electroencephalography; Male; Platelet Aggregation; Rats; Rats, Inbred Strains; Salicylates | 1987 |
Effect of single-dose aspirin on TXA2 and PGI2 cyclooxygenases in vivo.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Dose-Response Relationship, Drug; Epoprostenol; Mice; Osmolar Concentration; Prostaglandin-Endoperoxide Synthases; Thromboxane A2 | 1987 |
Altered intraplatelet arachidonic acid metabolism during the acute state of unstable angina.
Topics: Acute Disease; Angina Pectoris; Angina, Unstable; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Female; Humans; In Vitro Techniques; Male; Middle Aged; Thromboxane A2 | 1987 |
Effect of lipopolysaccharides on cultured human endothelial cells. Relationship between tissue factor activity and prostacyclin release.
Topics: 6-Ketoprostaglandin F1 alpha; Adenine; Arachidonic Acid; Arachidonic Acids; Aspirin; Cells, Cultured; Endothelium; Epoprostenol; Humans; L-Lactate Dehydrogenase; Lipopolysaccharides; Thromboplastin; Time Factors; Tritium | 1987 |
Antithrombotic and ulcerogenic effects of fenflumizole, a new anti-inflammatory imidazole derivative, in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Imidazoles; Male; Platelet Aggregation; Rats; Rats, Inbred Strains; Stomach Ulcer; Thromboembolism | 1987 |
The action of erythropoietin is mediated by lipoxygenase metabolites in murine fetal liver cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Butylated Hydroxyanisole; Erythropoiesis; Erythropoietin; Hydroxyeicosatetraenoic Acids; Liver; Masoprocol; Meclofenamic Acid; Mice; Phosphatidylinositols; Pyrazoles | 1987 |
AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxycarbonyl-meth oxy coumarin) inhibits the release of arachidonic acid in human platelets stimulated by thrombin.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Chromonar; Coumarins; Diglycerides; Dose-Response Relationship, Drug; Humans; Phospholipids; Platelet Aggregation; Radioisotopes; Thrombin; Thromboxane B2 | 1987 |
[Prostaglandin synthesis in stomach and duodenal mucosa of the human: effect of aspirin with and without antacid].
Topics: Adult; Aluminum Hydroxide; Antacids; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium Carbonate; Drug Combinations; Duodenum; Gastric Mucosa; Humans; Intestinal Mucosa; Magnesium; Magnesium Hydroxide; Prostaglandins | 1987 |
Alteration of uptake and distribution of eicosanoid precursor fatty acids by aspirin.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Fatty Acids; Humans; Linoleic Acid; Linoleic Acids; Membrane Lipids; Monocytes; Phospholipids; Prostaglandins | 1987 |
Arachidonic acid metabolites and airway epithelium-dependent relaxant factor.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Aspirin; Biological Products; Carbachol; Epithelium; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Male; Masoprocol; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Pyrazoles; Trachea | 1987 |
Platelets, eicosanoids, and coronary vasospasm.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cattle; Coronary Vasospasm; Coronary Vessels; Eicosanoic Acids; Humans; In Vitro Techniques; Methysergide; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Salicylates; Salicylic Acid; Vasoconstriction | 1987 |
Eicosanoids and aspirin-sensitive asthma.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Blood Platelets; Humans; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Thromboxane A2; Thromboxanes | 1987 |
The effect of vitreous humour on prostaglandin production by cultured rabbit chorioretinal fibroblasts.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Ascorbic Acid; Aspirin; Cells, Cultured; Choroid; Colforsin; Dexamethasone; Enzyme Activation; Fibroblasts; Masoprocol; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rabbits; Retina; Vitreous Body | 1987 |
Identification of novel arachidonic acid metabolites formed by prostaglandin H synthase.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Gas Chromatography-Mass Spectrometry; Humans; Indomethacin; Male; Mass Spectrometry; Microsomes; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins G; Prostaglandins H; Seminal Vesicles; Spectrophotometry, Ultraviolet | 1987 |
Current modalities in arthritic diseases.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Arthritis; Aspirin; Humans; Inflammation; Pain; Prostaglandin-Endoperoxide Synthases | 1987 |
Inhibitory effects of tryptophan pyrolysis products on human platelet aggregation through inhibition of prostaglandin endoperoxide synthetase.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Carbolines; Cyclooxygenase Inhibitors; Food Analysis; Humans; Male; Neutrophils; Platelet Aggregation; Platelet Aggregation Inhibitors | 1987 |
Sex-related differences in platelet aggregation in native whole blood.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Female; Fibrinogen; Humans; Male; Platelet Aggregation; Sex Factors; Thrombin | 1987 |
Regulation of prostaglandin synthesis in human vascular cells.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Cells, Cultured; Endothelium, Vascular; Epoprostenol; Fibroblast Growth Factors; Heparin; Humans; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Stimulation, Chemical; Thrombin | 1987 |
Response of human platelets exposed to arachidonate upon stimulation with other agonists: possible role of Ca2+i movement.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Biological Transport; Blood Platelets; Calcium; Humans; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thrombin | 1987 |
Role of prostaglandins in blood-induced vasoconstriction of canine cerebral arteries.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood; Cerebral Arteries; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Dogs; Female; Ibuprofen; Indomethacin; Male; Meclofenamic Acid; Papaverine; Prostaglandins; Prostaglandins E; Prostaglandins F; Vasoconstriction | 1988 |
Effects of five non-steroidal anti-inflammatory drugs on the renal and systemic responses to arachidonate in conscious dogs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Aspirin; Dinoprostone; Dogs; Ibuprofen; Indomethacin; Kidney; Kidney Cortex; Microsomes; Phenylbutazone; Prostaglandins; Prostaglandins E; Sulindac | 1987 |
The association of in vitro arachidonic acid responsiveness and plasma thromboxane levels with early platelet deposition on the luminal surface of small-diameter grafts.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Benzofurans; Blood Vessel Prosthesis; Dogs; Graft Occlusion, Vascular; Platelet Aggregation; Polytetrafluoroethylene; Thromboxane B2; Thromboxane-A Synthase | 1988 |
Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Aspirin; Clotrimazole; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Indomethacin; Ketoconazole; Male; Masoprocol; Microsomes, Liver; NADP; Oxygenases; Rats; Rats, Inbred Strains | 1988 |
Mechanism of inhibition of cyclo-oxygenase in human blood platelets by carbamate insecticides.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Blood Proteins; Carbamates; Carbaryl; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Insecticides; Phenylcarbamates; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 1988 |
Comparative effects of inhibitors of arachidonic acid metabolism on erythropoiesis.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Butylated Hydroxyanisole; Cyclooxygenase Inhibitors; Erythropoiesis; Hematopoietic Stem Cells; Lipoxygenase Inhibitors; Masoprocol; Meclofenamic Acid; Mice; Pyrazoles | 1988 |
Exchange of cyclooxygenase dependent metabolites between vessel wall and platelets in arterial thrombosis.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Epoprostenol; Imidazoles; Male; Mesenteric Arteries; Platelet Aggregation; Propionates; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Thrombosis; Thromboxane A2; Tranylcypromine | 1988 |
Effects of cadmium treatment in vitro on the antioxidant protection mechanism and activation of human blood platelets.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cadmium; Calcium Chloride; Humans; Male; Malondialdehyde; Middle Aged; Oxidation-Reduction; Oxygen; Prostaglandin-Endoperoxide Synthases; Thrombin | 1988 |
Combined arachidonic acid and ADP platelet inhibition maximizes patency of small-diameter vascular grafts.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Vessel Prosthesis; Carotid Arteries; Dogs; Femoral Artery; Platelet Aggregation; Polytetrafluoroethylene; Thromboxane B2; Ticlopidine; Vascular Patency | 1988 |
The effect of drugs which affect the arachidonate cascade in burned rabbits.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Coagulation; Blood Platelets; Burns; Epoprostenol; Fibrinolysis; Kidney; Methacrylates; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Thromboxane-A Synthase | 1986 |
Why single daily dose of aspirin may not prevent platelet aggregation.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Drug Synergism; Female; Humans; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 1988 |
Prostaglandin H synthase: distinct binding sites for cyclooxygenase and peroxidase substrates.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Fatty Acids; Fatty Acids, Unsaturated; Kinetics; Leukotrienes; Lipid Peroxides; Peroxidases; Prostaglandin-Endoperoxide Synthases; Sheep | 1988 |
[Tracheal instillation of arachidonic acid as an asthma model in guinea pigs--preliminary results of the effect of inhibitors of arachidonic acid metabolism].
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Cyclooxygenase Inhibitors; Disease Models, Animal; Guinea Pigs; Lipoxygenase Inhibitors | 1988 |
Corticosteroids suppress cyclooxygenase messenger RNA levels and prostanoid synthesis in cultured vascular cells.
Topics: Adrenal Cortex Hormones; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Cortisone; Cycloheximide; Dactinomycin; Dexamethasone; DNA Probes; Drug Synergism; Epidermal Growth Factor; Male; Muscle, Smooth, Vascular; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Inbred Strains; RNA, Messenger; Transforming Growth Factors | 1988 |
Acetyl glycerylphosphorylcholine aggregates human platelets through two distinct pathways, both dependent on arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Catechols; Chromatography, Thin Layer; Cyclooxygenase Inhibitors; Humans; Imidazoles; In Vitro Techniques; Lipoxygenase Inhibitors; Masoprocol; Phospholipases; Platelet Activating Factor; Platelet Aggregation; Prostanoic Acids; Quinacrine; Radioimmunoassay; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase | 1985 |
Protective effects of the antianginal agent nicorandil on arachidonate-induced sudden death in rats: comparison with several antianginal agents and cyclooxygenase inhibitors.
Topics: Angina Pectoris; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Death, Sudden; Diltiazem; Indomethacin; Male; Mice; Niacinamide; Nicorandil; Nitroglycerin; Rats; Rats, Inbred Strains; Vasodilator Agents | 1985 |
Comparative pharmacology of cyclooxygenase inhibitors on platelet function.
Topics: 2,2'-Dipyridyl; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Docosahexaenoic Acids; Fatty Acids, Unsaturated; Heme; Humans; Ibuprofen; Iron; Platelet Aggregation | 1985 |
Arachidonate metabolism in renal injury.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Dinoprostone; Hydronephrosis; Kidney; Macrophages; Methacrylates; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Rabbits; Thromboxane-A Synthase; Ureteral Obstruction; Vasoconstriction | 1985 |
The effects of cyclooxygenase and lipoxygenase inhibitors on the collagen abnormalities of diabetic rats.
Topics: Acetaminophen; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Female; Indomethacin; Lipoxygenase Inhibitors; Naproxen; Rats; Rats, Inbred Strains | 1985 |
Arachidonic acid metabolism and inhibition of cyclooxygenase in platelets from asthmatic subjects with aspirin intolerance.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Blood Platelets; Cyclooxygenase Inhibitors; Drug Tolerance; Humans; Lipoxygenase; Prostaglandin-Endoperoxide Synthases | 1985 |
Prostaglandins and human platelet aggregation. Implications for the anti-aggregating activity of thromboxane-synthase inhibitors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Dinoprost; Dinoprostone; Drug Synergism; Humans; Imidazoles; Oxidoreductases; Platelet Aggregation; Prostaglandin D2; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Prostaglandins D; Prostaglandins E; Prostaglandins F; Prostanoic Acids; Thromboxane B2; Thromboxane-A Synthase | 1985 |
Formation of 11-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid in human umbilical arteries is catalyzed by cyclooxygenase.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Catechols; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Infant, Newborn; Masoprocol; Prostaglandin-Endoperoxide Synthases; Subcellular Fractions; Umbilical Arteries | 1985 |
Restoration of prostacyclin synthase in vascular smooth muscle cells after aspirin treatment: regulation by epidermal growth factor.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood; Cycloheximide; Cytochrome P-450 Enzyme System; Epidermal Growth Factor; Epoprostenol; Intramolecular Oxidoreductases; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Comparative in vivo inhibitory effects of nonsteroidal anti-inflammatory agents on prostaglandin synthesis in rabbit ocular tissues.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Conjunctiva; Dinoprostone; Flurbiprofen; Indomethacin; Injections, Intraperitoneal; Prostaglandins E; Rabbits; Uvea | 1985 |
Inhibition of platelet adhesion to aortic subendothelium by indomethacin--an effect unrelated to inhibition of arachidonic acid metabolism.
Topics: Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Aspirin; Endothelium; In Vitro Techniques; Indomethacin; Platelet Adhesiveness; Rabbits | 1985 |
Prostanoid synthesis in peripheral nerve.
Topics: Animals; Anura; Arachidonic Acid; Arachidonic Acids; Aspirin; Chromatography, Thin Layer; Electric Stimulation; Glutathione; Indomethacin; Peripheral Nerves; Prostaglandins; Rats; Sciatic Nerve | 1985 |
Prostaglandin synthesis by the cochlea of the guinea pig. Influence of aspirin, gentamicin, and acoustic stimulation.
Topics: Acoustic Stimulation; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cochlea; Gentamicins; Guinea Pigs; Male; Prostaglandins | 1985 |
Indomethacin and salicylate modulate effect of insulin on glucose kinetics in dogs.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Glucose; Dogs; Drug Interactions; Female; Gluconeogenesis; Glucose; Indomethacin; Insulin; Kinetics; Liver; Prostaglandin Antagonists; Prostaglandins; Salicylates; Salicylic Acid; Time Factors | 1985 |
Failure of superoxide dismutase to alter equine arachidonic acid-induced platelet aggregation, in vitro or ex vivo.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Female; Horses; In Vitro Techniques; Male; Platelet Aggregation; Superoxide Dismutase | 1985 |
Morphological alterations in cultured endothelial cells induced by arachidonic acid.
Topics: Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Aspirin; Cattle; Dinoprostone; Dose-Response Relationship, Drug; Endothelium; Fatty Acids; Female; Ibuprofen; Indomethacin; Kinetics; Male; Phospholipids; Prostaglandins E; Pulmonary Artery; SRS-A; Time Factors | 1985 |
Sex difference in the effect of aspirin on rat platelet aggregation and arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Castration; Collagen; Female; Male; Malondialdehyde; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Sex Factors; Thrombin | 1985 |
Vascular effects of 15-hydroperoxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid on canine arteries.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arteries; Aspirin; Cerebral Angiography; Cerebral Arteries; Coronary Vessels; Dogs; Hydroxyeicosatetraenoic Acids; Imidazoles; In Vitro Techniques; Leukotrienes; Lipid Peroxides; Male; Tranylcypromine; Vasoconstrictor Agents | 1985 |
Effect of inhibitors of proteolysis and arachidonic acid metabolism on burn-induced protein breakdown.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Burns; Hindlimb; Ibuprofen; In Vitro Techniques; Indomethacin; Leupeptins; Lysosomes; Muscles; Oligopeptides; Peptide Hydrolases; Protease Inhibitors; Proteins; Quinacrine; Rats; Rats, Inbred Strains; Tyrosine | 1985 |
Prostaglandin involvement in hypersensitivity of ischemic hearts to arrhythmogenic influence of ouabain.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Arrhythmias, Cardiac; Aspirin; Coronary Circulation; Coronary Disease; Coronary Vessels; Dinoprost; Dinoprostone; Epoprostenol; Guinea Pigs; Ibuprofen; Indomethacin; Ligation; Male; Ouabain; Perfusion; Prostaglandins; Prostaglandins E; Prostaglandins F; Time Factors | 1985 |
The tachyphylactic effect of arachidonic acid on in-vivo ADP induced arterial platelet thrombosis.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Coagulation; Drug Synergism; Rats; Thrombosis | 1985 |
Polymorphonuclear leukocyte: arachidonate edema.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Catalase; Catechols; Endothelium; Epoprostenol; Humans; In Vitro Techniques; Indomethacin; Masoprocol; Neutrophils; Papaverine; Perfusion; Physiology; Pulmonary Edema; Rabbits; Serum Albumin, Bovine | 1985 |
Long-term ultra-low-dose aspirin therapy and platelet function.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Bleeding Time; Collagen; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Male; Platelet Aggregation; Thromboxane B2; Thromboxanes; Time Factors | 1985 |
Dopamine-induced potentiation of the contractile response to arachidonic acid in guinea-pig aorta.
Topics: Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Aspirin; Catechols; Corticosterone; Dopamine; Drug Synergism; Guinea Pigs; Indomethacin; Male; Masoprocol; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phentolamine | 1985 |
Endothelial cells produce a lipoxygenase derived chemo-repellent which influences platelet/endothelial cell interactions--effect of aspirin and salicylate.
Topics: Adenine; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cell Adhesion; Cells, Cultured; Endothelium; Female; Humans; Kinetics; Lipoxygenase; Phospholipids; Platelet Adhesiveness; Pregnancy; Prostaglandin-Endoperoxide Synthases; Salicylates; Salicylic Acid; Umbilical Veins | 1985 |
Effects of aspirin and propranolol on feline platelet aggregation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cats; Depression, Chemical; Dose-Response Relationship, Drug; Female; Male; Platelet Aggregation; Propranolol | 1985 |
Aspirin-sensitive asthma: abnormal platelet response to drugs inducing asthmatic attacks. Diagnostic and physiopathological implications.
Topics: Adult; Aged; Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Blood Platelets; Cyclooxygenase Inhibitors; Cytotoxicity, Immunologic; Desensitization, Immunologic; Drug Hypersensitivity; Female; Humans; Immunity, Cellular; Immunoglobulin E; Leukocytes; Luminescent Measurements; Male; Middle Aged; Platelet Aggregation; Schistosoma mansoni | 1985 |
Interaction of non-steroidal anti-inflammatory drugs on platelet cyclo-oxygenase and lipoxygenase activity.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Humans; Indomethacin; Kinetics; Lipoxygenase; Models, Biological; Prostaglandin-Endoperoxide Synthases; Salicylates; Salicylic Acid; Sulfinpyrazone | 1985 |
Prostaglandin-related bone resorption in cultured neonatal mouse calvaria: evaluation of biopotency of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Bone Resorption; Cells, Cultured; Indomethacin; Mice; Mice, Inbred Strains; Parathyroid Hormone; Prostaglandins; Thrombin | 1985 |
The antiinflammatory activity of the immunomodulator Wy-18,251 (3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid).
Topics: Adjuvants, Immunologic; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Arthritis, Experimental; Aspirin; Benzimidazoles; Collagen; Fever; Gastric Mucosa; Hyperesthesia; Inflammation; Levamisole; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Lew; Rats, Inbred Strains | 1985 |
In vivo modulation of leukotaxis by non-steroidal anti-inflammatory drugs.
Topics: Animals; Anterior Chamber; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Chemotaxis, Leukocyte; Female; Flurbiprofen; Ibuprofen; Indomethacin; N-Formylmethionine Leucyl-Phenylalanine; Rabbits | 1985 |
Arachidonic acid metabolism in thrombocytes and vascular tissues of turkeys.
Topics: Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Epinephrine; Female; Hemodynamics; In Vitro Techniques; Male; Nitroglycerin; Platelet Aggregation; Prostaglandins; Species Specificity; Turkeys | 1985 |
Platelet aggregation in whole blood: the role of thromboxane A2 and adenosine diphosphate.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenosine Diphosphate; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Cyclooxygenase Inhibitors; Epinephrine; Flurbiprofen; Humans; Imidazoles; In Vitro Techniques; Lipoxygenase Inhibitors; Platelet Aggregation; Pyrazoles; Thrombin; Thromboxane A2; Thromboxane-A Synthase | 1985 |
Arachidonic acid and leukotriene B4 induce aggregation of human peripheral blood mononuclear leucocytes in vitro.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Catechols; Cell Aggregation; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Indomethacin; Leukocytes; Leukotriene B4; Masoprocol; Neutrophils; Pyrazoles | 1984 |
Interactions of vasopressin, prostaglandins, and cAMP in rat renal papillary collecting tubule cells in culture.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arginine Vasopressin; Aspirin; Cells, Cultured; Cyclic AMP; Cyclooxygenase Inhibitors; Kidney Tubules; Kidney Tubules, Collecting; Prostaglandins E; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1984 |
Platelet accumulation on collagen: drugs which inhibit arachidonic acid metabolism and affect intracellular cyclic AMP levels.
Topics: Alprostadil; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Cyclic AMP; Humans; In Vitro Techniques; Indomethacin; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins; Prostaglandins E; Thromboxanes | 1984 |
C5a-induced aortic contraction: effect of an antihistamine and inhibitors of arachidonate metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Complement C5; Complement C5a; Cyclooxygenase Inhibitors; Diphenhydramine; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Male; Muscle Contraction; Muscle, Smooth, Vascular | 1982 |
Inhibition of prostaglandin synthesis in rabbit kidney medulla slices by antioxidants.
Topics: Animals; Antioxidants; Arachidonic Acid; Arachidonic Acids; Aspirin; Ditiocarb; In Vitro Techniques; Kidney Medulla; Lipid Peroxides; Male; Phenols; Phenylenediamines; Prostaglandins; Prostaglandins E; Quinacrine; Rabbits; Time Factors | 1984 |
Effect of central prostaglandins on carrageenan-induced pedal oedema in rats.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Carrageenan; Diclofenac; Dinoprost; Dinoprostone; Edema; Female; Injections, Intraventricular; Male; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats | 1984 |
Evidence that phosphatidylinositol breakdown releases arachidonic acid, forming prostaglandins which are involved in stimulus-secretion coupling in the exocrine pancreas.
Topics: Amylases; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Mice; Pancreas; Phosphatidylinositols; Prostaglandins | 1981 |
Independent mechanisms for bradykinin-mediated prostaglandin E2 and cyclic GMP syntheses in rabbit renal inner medulla slices.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Bradykinin; Calcium; Cyclic GMP; Dinoprostone; In Vitro Techniques; Kidney Medulla; Prostaglandins E; Rabbits; Time Factors | 1982 |
Independent effects of bradykinin on adenosine 3',5'-monophosphate and prostaglandin E2 metabolism by rabbit renal medulla.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antihypertensive Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Bradykinin; Colforsin; Cyclic AMP; Dinoprostone; Diterpenes; In Vitro Techniques; Kidney Medulla; Kinetics; Prostaglandins E; Rabbits | 1984 |
Pharmacological studies on OKY-1581: a selective thromboxane synthetase inhibitor.
Topics: Acrylates; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Biological Assay; Blood Platelets; Cerebral Infarction; Haplorhini; Kinetics; Methacrylates; Muscle Contraction; Oxidoreductases; Platelet Aggregation; Rabbits; Rats; Thrombosis; Thromboxane A2; Thromboxane-A Synthase | 1983 |
In vivo and in vitro effects of arachidonic acid products on liver cell integrity following carbon tetrachloride poisoning.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Alanine Transaminase; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Carbon Tetrachloride Poisoning; Epoprostenol; Female; Indomethacin; Liver; Lysine; Peroxides; Prostaglandins; Pyrazoles; Rats; Rats, Inbred Strains | 1983 |
Aspirin decreases platelet uptake on Dacron vascular grafts in baboons.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Vessel Prosthesis; Carotid Arteries; Graft Survival; Indium; Male; Papio; Platelet Adhesiveness; Platelet Aggregation; Polyethylene Terephthalates; Radioisotopes; Radionuclide Imaging; Thromboxane B2; Time Factors | 1984 |
Effects of AVS (1,2-bis(nicotinamido)propane) on platelet function and vascular endothelium.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Blood Vessels; Cerebrovascular Disorders; Collagen; Dinoprostone; Endothelium; In Vitro Techniques; Mice; Microscopy, Electron, Scanning; Niacinamide; Platelet Aggregation; Prostaglandins E; Rabbits; Rats; Rats, Inbred Strains; Thromboembolism; Thrombosis; Thromboxane A2 | 1984 |
Polymyalgia rheumatica and giant cell arteritis--rational diagnosis and treatment predicated and disordered prostaglandin metabolism.
Topics: Acid Phosphatase; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Sedimentation; Humans; Models, Biological; Muramidase; Peptidyl-Dipeptidase A; Polymyalgia Rheumatica; Prostaglandins; Prostaglandins F | 1981 |
Effects of stimulators and inhibitors on arachidonic acid metabolism in hepatoma.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Butylated Hydroxytoluene; Carcinoma, Hepatocellular; Indomethacin; Liver Neoplasms; Prostaglandins; Rats; Sodium Salicylate; Thromboxane B2; Thromboxanes; Tryptophan | 1981 |
cis-Polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Fatty Acids, Unsaturated; Humans; Indomethacin; Kinetics; Neutrophils; Oxygen; Structure-Activity Relationship; Superoxides | 1981 |
Evidence for the generation of hydroxyl radical during arachidonic acid metabolism by human platelets.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Carbon Dioxide; Cell Separation; Dimethyl Sulfoxide; Free Radicals; Humans; Hydroxides; Hydroxyl Radical; Thromboxane B2; Time Factors | 1981 |
The effects of arachidonic acid, PGI2, and 6-keto-PGF1 alpha on cyclic nucleotide concentrations in a ventilated and artificially perfused isolated dog lung.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cyclic AMP; Cyclic GMP; Dogs; Epoprostenol; In Vitro Techniques; Indomethacin; Kinetics; Lung; Perfusion; Prostaglandins; Tranylcypromine | 1982 |
Rabbit and rat renal papillary collecting tubule cells in culture: the interactions of arginine vasopressin, prostaglandins, and cyclic AMP.
Topics: 6-Ketoprostaglandin F1 alpha; Adenylyl Cyclases; Animals; Arachidonic Acid; Arachidonic Acids; Arginine Vasopressin; Aspirin; Calcimycin; Cells, Cultured; Cyclic AMP; Dinoprost; Dinoprostone; Kidney Tubules; Kinetics; Prostaglandins; Prostaglandins E; Prostaglandins F; Rabbits; Rats | 1983 |
Studies on aspirin derivatives with very little side effect. IV. Inhibitory effect of aspirin-isopropylantipyrine (AIA) on several experimental thromboses.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Antipyrine; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclic AMP; Epoprostenol; Malondialdehyde; Muscle Contraction; Rats; Thrombosis | 1983 |
Reactive oxygen production, arachidonate metabolism and cyclic AMP in macrophages.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Bucladesine; Calcimycin; Cyclic AMP; Dinoprostone; Indomethacin; Kinetics; Luminescent Measurements; Macrophages; Oxygen; Prostaglandins E; Rats; Verapamil | 1983 |
Effects of dazoxiben and low-dose aspirin on platelet behaviour in man.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Epinephrine; Female; Humans; Imidazoles; Male; Oxidoreductases; Thromboxane-A Synthase | 1983 |
Monitoring the entry of new platelets into the circulation after ingestion of aspirin.
Topics: Adenosine Triphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Female; Humans; Male; Middle Aged; Platelet Aggregation; Thromboxane B2; Time Factors | 1983 |
Inhibition of platelet aggregation by a new agent, 2,2'-dithiobis-(N-2-hydroxypropyl benzamide) (KF4939).
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Benzamides; Collagen; Dose-Response Relationship, Drug; Fibrinolytic Agents; Humans; In Vitro Techniques; Male; Mice; Papaverine; Platelet Aggregation; Rabbits; Rats; Rats, Inbred Strains; Thrombin; Thrombocytopenia; Thrombosis; Thromboxane A2 | 1983 |
The effects of aspirin and methysergide on responses to clot-induced pulmonary embolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Pressure; Dinoprost; Drug Therapy, Combination; Heart Rate; Male; Methysergide; Premedication; Prostaglandins F; Pulmonary Artery; Pulmonary Embolism; Rabbits; Respiration; Serotonin; Vascular Resistance | 1983 |
Analgesic-induced asthma.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Bronchial Spasm; Child; Cyclooxygenase Inhibitors; Humans; Lung; Prostaglandin-Endoperoxide Synthases | 1983 |
[Analgetic drug intolerance].
Topics: Analgesics; Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Complement Activation; Drug Hypersensitivity; Humans; Tartrazine; Urticaria | 1983 |
Human vascular tissues produce thromboxane as well as prostacyclin.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Epoprostenol; Female; Humans; Mammary Arteries; Middle Aged; Muscle, Smooth, Vascular; Pregnancy; Prostaglandins; Saphenous Vein; Thromboxane A2; Thromboxanes; Umbilical Arteries; Umbilical Veins | 1983 |
The role of ADP secretion and thromboxane synthesis in factor VIII binding to platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Factor VIII; Humans; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxane A2; Thromboxanes | 1983 |
Effects of inhibitors of arachidonic acid metabolism and calcium entry on responses to acetylcholine, potassium and norepinephrine in the isolated canine saphenous vein.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium Channel Blockers; Dogs; Electric Stimulation; Female; Indomethacin; Kinetics; Male; Meclofenamic Acid; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Saphenous Vein | 1983 |
Interferon-mediated inhibition of prostaglandin synthesis in human mononuclear leukocytes.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Dose-Response Relationship, Immunologic; Humans; Immune Tolerance; Interferon Type I; Leukocytes; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Prostaglandins E | 1983 |
Thromboxane A2 generation by the larval cestode, Taenia taeniaeformis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Horses; Imidazoles; Indomethacin; Kinetics; Larva; Platelet Aggregation; Rats; Taeniasis; Thromboxane A2; Thromboxane B2; Thromboxanes | 1983 |
Asthma and anti-inflammatory drugs. Mechanisms and clinical patterns.
Topics: Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Humans; Lung | 1983 |
Suppression of lymphatic vessel contractility with inhibitors of arachidonic acid metabolism.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cattle; Dinoprost; Indomethacin; Lymphatic System; Muscle Contraction; Prostaglandin Endoperoxides, Synthetic; Prostaglandins F; SRS-A | 1983 |
Effect of anti-inflammatory drugs on endotoxin-induced diarrhea in mice.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Diarrhea; Drug Interactions; Endotoxins; Erythema; Guinea Pigs; Male; Mice; Rabbits | 1983 |
Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Catechols; Collagen; Humans; Lipoxygenase Inhibitors; Masoprocol; Platelet Adhesiveness; Platelet Aggregation | 1983 |
The effects of aspirin and dipyridamole on the metabolism of arachidonic acid in human platelets.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Dipyridamole; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Humans; In Vitro Techniques; Leukotrienes; Male; Thromboxane B2 | 1983 |
Arachidonic acid metabolism and the adhesion of human polymorphonuclear leukocytes to cultured vascular endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Arachidonic Acids; Aspirin; Cell Adhesion; Cells, Cultured; Endothelium; Humans; Lipoxygenase; Neutrophils; Prostaglandin-Endoperoxide Synthases | 1983 |
Some properties of mouse platelets.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Epoprostenol; Indomethacin; Lipoxygenase; Male; Mice; Mice, Inbred ICR; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases | 1983 |
Prostacyclin biosynthesis in cultured vascular endothelium is limited by deactivation of cyclooxygenase.
Topics: Antioxidants; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Endothelium; Epoprostenol; Humans; Ibuprofen; Peroxidases; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Thrombin; Umbilical Veins | 1983 |
Release of prostacyclin (PGI2) by the layers of corpus of rat stomach.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Epoprostenol; Gastric Mucosa; Male; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Rats; Rats, Inbred Strains; Stomach | 1983 |
The metabolism of arachidonic acid in hamster lung microsomes is not completely inhibited by aspirin and indomethacin.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Carbon Radioisotopes; Cricetinae; Female; Hydrogen-Ion Concentration; Indomethacin; Kinetics; Lung; Mesocricetus; Microsomes; NADP; Prostaglandins | 1983 |
Differential effect of acetylsalicylic acid and dipyrone on prostaglandin production in human fibroblast cultures.
Topics: Aminopyrine; Arachidonic Acid; Arachidonic Acids; Aspirin; Bradykinin; Cell Membrane; Cells, Cultured; Child, Preschool; Dinoprost; Dinoprostone; Dipyrone; Epoprostenol; Fibroblasts; Humans; Male; Prostaglandins; Prostaglandins E; Prostaglandins F | 1983 |
Sensitivity of rabbit platelet and aortic cyclooxygenase to inhibition by aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Epoprostenol; Female; In Vitro Techniques; Rabbits; Thrombosis; Thromboxane B2 | 1983 |
Prostaglandins and related compounds -- a general physiologic control system.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Diet; Epoprostenol; Fatty Acids; Female; Humans; Indomethacin; Pregnancy; Prostaglandins; SRS-A; Thromboxane A2; Thromboxanes | 1983 |
[Respiratory manifestations and intolerance to aspirin and non-steroidal anti-inflammatory agents].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Bradykinin; Bronchial Provocation Tests; Drug Hypersensitivity; Humans; Middle Aged; Prostaglandins; Respiratory Tract Diseases; Skin Tests | 1984 |
Lymphocytes sensitize rat isolated atria to the inotropic and chronotropic effects of sodium arachidonate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Heart Rate; In Vitro Techniques; Indomethacin; Lymphocytes; Male; Myocardial Contraction; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Unidirectional transfer of prostaglandin endoperoxides between platelets and endothelial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcimycin; Cattle; Cell Communication; Endothelium; Epoprostenol; Humans; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandins F; Thromboxane B2 | 1984 |
Relationships between the chemical constitution of aggregation inhibitors and human blood platelet response profile.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Calcium; Calcium Channel Blockers; Carbamates; Chlorpromazine; Gallic Acid; Humans; In Vitro Techniques; Piperidines; Platelet Aggregation; Propranolol; Thrombin | 1984 |
Activation of phospholipase C is dissociated from arachidonate metabolism during platelet shape change induced by thrombin or platelet-activating factor. Epinephrine does not induce phospholipase C activation or platelet shape change.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Enzyme Activation; Epinephrine; Humans; Indomethacin; Kinetics; Phospholipases; Platelet Activating Factor; Platelet Aggregation; Thrombin; Trifluoperazine; Type C Phospholipases | 1984 |
Effects of tris on responses of human and rabbit platelets to aggregating agents.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Calcium; Collagen; Dose-Response Relationship, Drug; Humans; Platelet Activating Factor; Platelet Aggregation; Rabbits; Serotonin; Thrombin; Tromethamine | 1984 |
Antiinflammatory properties of a hydroperoxide compound, structurally related to acetylsalicylic acid.
Topics: Animals; Anti-Inflammatory Agents; Aorta; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Epoprostenol; Humans; In Vitro Techniques; Neutrophils; Phthalic Acids; Phthalic Anhydrides; Rabbits | 1984 |
Evidence for the involvement of arachidonic acid metabolites in spontaneous and drug-induced contractions of rat urinary bladder.
Topics: Adenosine Diphosphate; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Diet; Fatty Acids, Essential; Hexamethonium Compounds; Indomethacin; Ketoprofen; Male; Muscle Contraction; Physostigmine; Piroxicam; Rats; Rats, Inbred Strains; Tetrodotoxin; Thiazines; Urinary Bladder | 1984 |
The effects of aspirin and OKY-1581 on the metabolism of exogenous arachidonic acid in rat alveolar macrophages.
Topics: Acrylates; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Dinoprost; Dinoprostone; Macrophages; Methacrylates; Oxidoreductases; Prostaglandins E; Prostaglandins F; Pulmonary Alveoli; Rats; Thromboxane B2; Thromboxane-A Synthase | 1984 |
Reversible inhibition of thromboxane A2 production by imidazole 2-hydroxybenzoate (ITF 182) in the arachidonic acid injected rat. A comparison with acetylsalicylic acid and indometacin.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Imidazoles; Indomethacin; Injections, Intravenous; Male; Prostaglandins; Rats; Rats, Inbred Strains; Salicylates; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes | 1984 |
Comparative study on the effects of acetylsalicylic acid, indomethacin and paracetamol on metabolites of arachidonic acid in plasma, serum and urine in man.
Topics: Acetaminophen; Arachidonic Acid; Arachidonic Acids; Aspirin; Dinoprostone; Humans; Indomethacin; Prostaglandins E; Thromboxane B2 | 1983 |
Sex difference in the inhibitory effect of aspirin on prostacyclin production of rat aortae.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Castration; Epoprostenol; Estradiol; Female; Gonadal Steroid Hormones; Male; Rats; Rats, Inbred Strains; Sex Characteristics; Testosterone | 1984 |
The effect of acetylsalicylate on aggregation and arachidonate metabolism by human platelets suspended in plasma or buffer.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Buffers; Humans; Phospholipids; Platelet Aggregation | 1984 |
Comparison of the effects of selective inhibition of thromboxane synthase with those of inhibition of the cyclooxygenase enzyme in man.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Imidazoles; Male; Oxidoreductases; Pyridines; Thromboxane-A Synthase; Time Factors | 1984 |
Macrophage-dependent arachidonate metabolism in hydronephrosis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Bradykinin; Chromatography, Thin Layer; Dinoprostone; Disease Models, Animal; Endotoxins; Hydronephrosis; Kidney Cortex; Macrophages; Male; Mechlorethamine; Microsomes; Prostaglandins E; Rabbits; Thromboxane B2; Time Factors | 1984 |
Prostaglandin endoperoxides and thromboxane A2 in thrombus formation in the hamster cheek pouch in vivo.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cheek; Cricetinae; Cyclooxygenase Inhibitors; Dipyridamole; Epoprostenol; Male; Mesocricetus; Microscopy, Electron; Platelet Aggregation; Sulfinpyrazone; Thrombosis; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1984 |
Aggregation of bovine platelets by acetyl glyceryl ether phosphorylcholine (platelet activating factor).
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cattle; In Vitro Techniques; Inflammation; Platelet Activating Factor; Platelet Aggregation | 1984 |
Effect of inhibitors of the lipoxygenase pathway on mouse myoblast fusion.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cell Fusion; Cells, Cultured; Cyclooxygenase Inhibitors; Indomethacin; Lipoxygenase Inhibitors; Mice; Muscles; Pyrazoles; Umbelliferones | 1984 |
Evidence for a two-step process in prostaglandin secretion. Intracellular accumulation of prostacyclin precedes its release from human endothelial cells in culture.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Cells, Cultured; Endothelium; Epoprostenol; Humans; Thrombin; Umbilical Veins | 1984 |
The effect of aspirin on the metabolism of exogenous arachidonic acid in human polymorphonuclear leukocytes.
Topics: Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Carbon Radioisotopes; Humans; Lipoxygenase; Neutrophils; Prostaglandin-Endoperoxide Synthases | 1984 |
Hypersensitivity to norepinephrine in vasa deferentia from diabetic rats. Possible participation of metabolic products of arachidonic acid.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Carbon Radioisotopes; Catechols; Diabetes Mellitus, Experimental; Indomethacin; Male; Masoprocol; Muscle Contraction; Muscle, Smooth; Norepinephrine; Phenoxybenzamine; Prostaglandin D2; Prostaglandins; Prostaglandins D; Rats; Rats, Inbred Strains; Vas Deferens | 1984 |
The role of metabolic activation of analgesics and non-steroidal anti-inflammatory drugs in the development of renal papillary necrosis and upper urothelial carcinoma.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Biotransformation; Drug Synergism; Humans; Kidney; Necrosis; Peroxidases; Urinary Bladder Neoplasms | 1984 |
Human lymphocyte aggregation?
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Cell Aggregation; Humans; In Vitro Techniques; Lymphocytes; Prostaglandin-Endoperoxide Synthases; Thromboxane A2 | 1984 |
Inhibitory activity of indobufen (*) on platelet aggregation in vivo.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Depression, Chemical; Isoindoles; Lethal Dose 50; Male; Mice; Phenylbutyrates; Platelet Aggregation | 1984 |
[Thrombocyte interaction with a collagen substrate: the role of thrombocyte-synthesized prostaglandin endoperoxides and thromboxane A2].
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Humans; Microscopy, Electron, Scanning; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Thrombosis; Thromboxane A2; Thromboxanes | 1984 |
Reduced glutathione modulates the arachidonic acid induced coronary reactions.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Coronary Circulation; Coronary Vessels; Glutathione; Guinea Pigs; Heart; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Vasoconstriction | 1984 |
Variable inotropic effect of immune cells on mice atria--participation of metabolic products of arachidonic acid.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Catechols; Dithizone; In Vitro Techniques; Indomethacin; Lymph Nodes; Male; Masoprocol; Mice; Mice, Inbred BALB C; Myocardial Contraction; Myocardium; T-Lymphocytes | 1984 |
The combined effects of sodium salicylate, aspirin and indomethacin on the metabolism of arachidonic acid in human platelets.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Drug Interactions; Humans; In Vitro Techniques; Indomethacin; Male; Prostaglandin-Endoperoxide Synthases; Sodium Salicylate | 1984 |
Dependence of arachidonic acid (AA) metabolization in human blood platelets on reduced coenzymes.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Diamide; Glutathione; Humans; NADP; Oxidation-Reduction | 1984 |
Platelet prostanoids in interaction of platelets with collagen substrates. II. Effects of exogenous arachidonic acid, stable PG endoperoxides analogue, and aspirin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cattle; Collagen; Humans; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxanes | 1984 |
Influence of aspirin, molsidomine, trapidil, and some trapidil derivatives on arachidonic acid induced reversible thrombocyte aggregation in the rabbit.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Molsidomine; Oxadiazoles; Platelet Aggregation; Pyrimidines; Rabbits; Structure-Activity Relationship; Sydnones; Trapidil; Vasodilator Agents | 1984 |
Inhibition of arachidonate-induced human platelet aggregation by a single low oral dose of aspirin in combination with a thromboxane synthase inhibitor.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Female; Humans; Imidazoles; Male; Oxidoreductases; Platelet Aggregation; Thromboxane-A Synthase | 1984 |
[Chemiluminescence of thrombocytes in thrombin-induced aggregation].
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Humans; Hydrogen Peroxide; In Vitro Techniques; Luminescent Measurements; Malondialdehyde; Platelet Aggregation; Thrombin | 1984 |
Effect of acetylsalicylic acid on glutathione consumption and hexose monophosphate shunt during arachidonic acid induced stimulation of human blood platelets.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Diamide; Glutathione; Hexosephosphates; Humans; Peroxides; Platelet Aggregation; tert-Butylhydroperoxide | 1984 |
Prostacyclin production in rabbit arteries in situ: inhibition by arachidonic acid-induced endothelial cell damage or by low-dose aspirin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Arteries; Aspirin; Ear; Endothelium; Epoprostenol; Male; Prostaglandins; Prostaglandins F; Rabbits; Thromboxane B2 | 1981 |
Stimulation of platelet protein phosphorylation by arachidonic acid and endoperoxide analogs.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Blood Proteins; Calcimycin; Humans; In Vitro Techniques; Kinetics; Phosphorylation; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Stimulation, Chemical | 1981 |
Platelet adherence to collagen: role of prostaglandin-thromboxane synthesis.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Collagen; Dose-Response Relationship, Drug; Humans; Imidazoles; Indomethacin; Magnesium; Middle Aged; Platelet Adhesiveness; Prostaglandins; Serotonin; Temperature; Thromboxanes | 1981 |
Arachidonic acid metabolites and the gastro-intestinal toxicity of anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Digestive System; Flurbiprofen; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Ketoprofen; Naproxen; Prostaglandins; Rats | 1981 |
A study of intravascular platelet aggregation by continuous platelet counting.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Dose-Response Relationship, Drug; Female; Imidazoles; Indomethacin; Male; Platelet Aggregation; Platelet Count; Prostaglandins H; Rabbits; Rats; Time Factors | 1981 |
Effect of non-steroidal anti-inflammatory drugs on arachidonic acid metabolism.
Topics: Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Humans; Indomethacin; Leukotrienes; Lipid Peroxides; Lipoxygenase; Peroxidases; Prostaglandin-Endoperoxide Synthases | 1981 |
Arachidonic acid, prostaglandin E2 and F2 alpha influence rates of protein turnover in skeletal and cardiac muscle.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cycloheximide; Diaphragm; Dinoprost; Dinoprostone; Indomethacin; Kinetics; Meclofenamic Acid; Muscle, Smooth; Muscles; Myocardium; Organ Specificity; Prostaglandins E; Prostaglandins F; Proteins; Rats | 1982 |
Rapid return of cyclo-oxygenase active platelets in dogs after a single oral dose of aspirin.
Topics: Administration, Oral; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Dogs; Humans; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Time Factors | 1981 |
A proposed role for prostaglandins in the modulation of the relaxation response to urotensin I in isolated rat arteries.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arteries; Aspirin; Atropine; Dose-Response Relationship, Drug; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Peptides; Propranolol; Prostaglandins; Pyrilamine; Rats; Rats, Inbred Strains; Urotensins | 1981 |
Unsaturated fatty acids and cyclooxygenase inhibitors: effects on pial arterioles.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Linoleic Acid; Linoleic Acids; Male; Mice; Norepinephrine; Pia Mater | 1982 |
Arachidonic acid induces human platelet-fibrin retraction: the role of platelet cyclic endoperoxides.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alprostadil; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Clot Retraction; Epoprostenol; Fatty Acids, Unsaturated; Fibrin; Humans; Imidazoles; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins D; Prostaglandins E; Prostaglandins H; Prostaglandins, Synthetic; Thromboxane B2 | 1982 |
Some perspectives on platelets and prostaglandins.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Humans; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandins; Thrombin; Thromboxanes | 1981 |
Reevaluation of sex differences in platelet aggregation in a physiologic system.
Topics: Adenosine Diphosphate; Adult; Aging; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Female; Humans; Infant, Newborn; Male; Platelet Aggregation; Sex Factors | 1981 |
Five methoxy-2-methyl-3-indole acetic acid. A metabolite and alkali hydrolysis product of indomethacin, markedly inhibits platelet aggregation only in the presence of aorta or a product released by aorta.
Topics: Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Epoprostenol; Indoleacetic Acids; Indomethacin; Male; Mice; Platelet Aggregation; Tissue Extracts | 1982 |
The effect of arachidonic acid on the aggregability of human platelet rich plasma.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Humans; Male; Platelet Aggregation; Time Factors | 1982 |
Enzymic coupling of acylhydrolase and prostaglandin synthase activities in subcellular fractions from rabbit renal medulla.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Carboxylic Ester Hydrolases; Dinoprostone; Fatty Acids; In Vitro Techniques; Kidney Medulla; Kinetics; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Rabbits; Subcellular Fractions | 1982 |
Studies on the incorporation of [1-14C]arachidonic acid into glycerolipids and its conversion into prostaglandins by rabbit iris. Effects of anti-inflammatory drugs and phospholipase A2 inhibitors.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Diglycerides; Female; Indomethacin; Iris; Lipid Metabolism; Male; Microsomes; Muscle, Smooth; Phospholipases; Phospholipases A; Phospholipases A2; Phospholipids; Prostaglandins; Quinacrine; Rabbits; Triglycerides | 1982 |
The effect of aspirin pretreatment on the fate of arachidonic acid in hamster isolated lungs.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Chromatography, Thin Layer; Cricetinae; Fatty Acids, Nonesterified; Female; Lung; Mesocricetus; Perfusion; Phospholipids; Tissue Distribution | 1982 |
Aspirin inhibits arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in hamster isolated lungs.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cricetinae; Cyclooxygenase Inhibitors; Female; Lipoxygenase Inhibitors; Lung; Mesocricetus; Perfusion | 1982 |
Indomethacin prevents the long-lasting inhibitory effect of aspirin on human platelet cyclo-oxygenase activity.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Drug Interactions; Female; Humans; Indomethacin; Male; Platelet Aggregation; Time Factors | 1982 |
[Effect of arachidonic acid on the secretion of milk caseins in vitro].
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Caseins; Female; In Vitro Techniques; Lactation; Mammary Glands, Animal; Milk; Pregnancy; Prolactin; Rabbits | 1982 |
Effect of acetaminophen and salicylate on aspirin-induced inhibition of human platelet cyclo-oxygenase.
Topics: Acetaminophen; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Humans; Salicylates; Thromboxane B2 | 1982 |
The facilitating effects of adrenaline on platelet aggregation.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Drug Synergism; Epinephrine; Humans; Platelet Aggregation; Radioimmunoassay; Thromboxane B2 | 1982 |
Serum levels of free fatty acids in the first trimester of pregnancy: effect of acetylsalicylic acid.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Fatty Acids, Nonesterified; Female; Humans; Middle Aged; Pregnancy; Pregnancy Trimester, First | 1982 |
Structure-activity studies of aspirin and related compounds on platelet aggregation, arachidonic acid metabolism in platelets and artery, and arterial prostacyclin activity.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Aspirin; Benzoates; Dinoprostone; Platelet Aggregation; Prostaglandins E; Rabbits; Rats; Structure-Activity Relationship | 1982 |
Opposite effect of lysine on platelet aggregation induced by arachidonate and by other aggregants.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Dose-Response Relationship, Drug; Drug Synergism; Humans; Lysine; Male; Malondialdehyde; Platelet Aggregation; Rats; Rats, Inbred Strains; Ristocetin; Serotonin | 1982 |
Effect of acetylsalicylic acid on platelet aggregation and thromboxane B2 production in flowing aortic blood in the rat studied with a filter loop technique.
Topics: Adenosine Diphosphate; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Aspirin; Male; Methods; Platelet Aggregation; Rats; Rats, Inbred Strains; Salicylates; Thromboxane B2; Thromboxanes | 1982 |
Platelet activating factor (PAF) causes human platelet aggregation through the mechanism of membrane modulation.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cell Membrane; Epinephrine; Epoprostenol; Humans; Platelet Activating Factor; Platelet Aggregation; Thromboxane B2; Time Factors | 1982 |
Platelet aggregation measured in rabbit whole blood: in vitro study of 3 aggregating agents and ex vivo inhibition by aspirin and ticlopidine.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; In Vitro Techniques; Platelet Aggregation; Platelet Count; Rabbits; Thiophenes; Ticlopidine | 1982 |
Arachidonate metabolism in cultured human vascular endothelial cells. Evidence for two prostaglandin synthetic pathways sensitive to acetylsalicylic acid.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cells, Cultured; Cycloheximide; Endothelium; Female; Humans; Kinetics; Muscle, Smooth, Vascular; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Umbilical Veins | 1982 |
Comparison of umbilical vein models for measurement of relative prostacyclin and thromboxane production.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Arachidonic Acids; Aspirin; Epoprostenol; Humans; Methacrylates; Models, Biological; Prostaglandins; Specimen Handling; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes; Umbilical Veins | 1982 |
Secretion of prostaglandins elicited by lipopolysaccharide and ethanol in cultured rat Kupffer cells.
Topics: Animals; Arachidonic Acid; Aspirin; Cells, Cultured; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Ethanol; Kinetics; Kupffer Cells; Lipopolysaccharides; Male; Prostaglandins; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Thrombin-receptor agonist peptides, in contrast to thrombin itself, are not full agonists for activation and signal transduction in human platelets in the absence of platelet-derived secondary mediators.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Arachidonic Acid; Aspirin; Blood Platelets; Cytoskeleton; Drug Interactions; GTP-Binding Proteins; Hirudins; Humans; Integrin alpha2; Membrane Glycoproteins; Molecular Sequence Data; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activation; Platelet Aggregation; Proto-Oncogene Proteins pp60(c-src); Purinergic P2 Receptor Antagonists; Receptors, Thrombin; Signal Transduction; Thrombin | 1994 |
Enhanced arachidonic acid metabolism in alveolar macrophages from wheezy infants. Modulation by dexamethasone.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Calcimycin; Case-Control Studies; Dexamethasone; Dose-Response Relationship, Drug; Female; Glucocorticoids; Humans; In Vitro Techniques; Infant; Ionophores; Leukotriene B4; Lysine; Macrophages, Alveolar; Male; Respiratory Sounds; Thromboxane A2 | 1995 |
Vasodilatation to arachidonic acid in humans. An insight into endogenous prostanoids and effects of aspirin.
Topics: Acetaminophen; Adult; Arachidonic Acid; Aspirin; Bradykinin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Hand; Humans; Male; Nitroglycerin; Prostaglandins; Reproducibility of Results; Time Factors; Vasodilation; Veins | 1995 |
Cytoprotective effects of CI-959 in the rat gastric mucosa: modulation of leukocyte adhesion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cell Adhesion; Dinoprostone; Dogs; Ethanol; Female; Gastric Acid; Gastric Mucosa; Histamine Antagonists; Indomethacin; Leukocytes; Leukotriene C4; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sulfhydryl Compounds; Tetrazoles; Thiophenes | 1995 |
Anti-thrombotic activity of KBT-3022 in experimental models of thrombosis.
Topics: Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Extracorporeal Circulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred Strains; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Silver Nitrate; Thiazoles; Thrombosis; Ticlopidine | 1995 |
Induction of prostanoid biosynthesis by bacterial lipopolysaccharide and isoproterenol in rat microglial cultures.
Topics: Animals; Arachidonic Acid; Aspirin; Astrocytes; Cells, Cultured; Dose-Response Relationship, Drug; Isoproterenol; Leukotriene B4; Lipopolysaccharides; Microglia; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Time Factors | 1995 |
In vitro release of arachidonic acid metabolites, glutathione peroxidase, and oxygen-free radicals from platelets of asthmatic patients with and without aspirin intolerance.
Topics: Adult; Arachidonic Acid; Aspirin; Asthma; Blood Platelets; Chromatography, High Pressure Liquid; Drug Hypersensitivity; Female; Glutathione Peroxidase; Humans; In Vitro Techniques; Lipoxygenase; Luminescent Measurements; Male; Superoxides | 1995 |
Aspirin as prophylaxis against colorectal cancer.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Colorectal Neoplasms; Female; Humans; Lipoxygenase; Prostaglandin-Endoperoxide Synthases | 1995 |
Low-dose aspirin inhibits arachidonic acid-precipitated platelet aggregation but not collagen-precipitated platelet aggregation.
Topics: Arachidonic Acid; Aspirin; Collagen; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; Humans; Platelet Aggregation | 1995 |
Interleukin-1 increases 15-hydroxyeicosatetraenoic acid formation in cultured human endothelial cells.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Arachidonate 15-Lipoxygenase; Arachidonic Acid; Aspirin; Base Sequence; Carbon Radioisotopes; Cells, Cultured; Endothelium; Gene Expression; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Interleukin-1; Masoprocol; Molecular Sequence Data; Monocytes; Polymerase Chain Reaction; Recombinant Proteins; RNA; RNA, Messenger | 1993 |
Inhibition of intercellular communication in rat hepatocytes by phenobarbital, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and gamma-hexachlorocyclohexane (lindane): modification by antioxidants and inhibitors of cyclo-oxygenase.
Topics: Animals; Antioxidants; Arachidonic Acid; Aspirin; Carcinogens; Cell Communication; Cells, Cultured; Cyclooxygenase Inhibitors; DDT; Hexachlorocyclohexane; Intercellular Junctions; Liver; Male; Phenobarbital; Rats; Rats, Wistar; Superoxide Dismutase; Vitamin E | 1993 |
Production of PGE2 and 15-HETE by fibrosarcoma cells.
Topics: Animals; Arachidonic Acid; Aspirin; Calcimycin; Carbon Radioisotopes; Cell Line; Chromatography, High Pressure Liquid; Dinoprostone; Fibrosarcoma; Gene Expression; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Interleukin-1; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Endothelium-dependent contraction induced by acetylcholine in isolated rat renal arteries.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arginine; Aspirin; Atropine; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Hexamethonium; Hydrazines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroarginine; Phospholipases A; Quinacrine; Rats; Rats, Inbred WKY; Receptors, Prostaglandin; Renal Artery; Terpenes; Thromboxane A2; Thromboxane-A Synthase | 1995 |
Endothelialization of cardiac valve bioprostheses.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Aspirin; Cattle; Cell Division; Cell Transplantation; Endothelial Growth Factors; Endothelium, Vascular; Epoprostenol; Fibroblast Growth Factor 2; Fibronectins; Glutaral; Heart Valve Prosthesis; Heparin; Humans; Microscopy, Electron, Scanning; Radioimmunoassay; Tissue Preservation | 1994 |
Fibroblast growth-promoting activity in proliferative vitreoretinopathy: antagonism by acetylsalicylic acid.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Cataract; Cell Division; Cells, Cultured; Colorimetry; Female; Fibroblasts; Humans; Male; Middle Aged; Retina; Retinal Detachment; Skin; Vitreoretinopathy, Proliferative; Vitreous Body | 1994 |
The effects of aspirin and paracetamol on the aggregation of equine blood platelets.
Topics: Acetaminophen; Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Cell Size; Collagen; Dose-Response Relationship, Drug; Horses; In Vitro Techniques; Nephelometry and Turbidimetry; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1994 |
Reduction in human neutrophil superoxide anion generation by n-3 polyunsaturated fatty acids: role of cyclooxygenase products and endothelium-derived relaxing factor.
Topics: Arachidonic Acid; Arginine; Aspirin; Depression, Chemical; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Humans; Indomethacin; Neutrophils; Nitric Oxide; omega-N-Methylarginine; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Respiratory Burst; Superoxides | 1994 |
The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s).
Topics: Animals; Arachidonic Acid; Aspirin; Catalysis; Cytosol; Endotoxins; Fatty Acids, Unsaturated; Glutathione; Glutathione Peroxidase; In Vitro Techniques; Isoenzymes; Liver; Male; Mitogens; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Transcription, Genetic | 1995 |
Dual inhibition of platelet-activating factor and arachidonic acid metabolism by ajmaline and effect on carrageenan-induced rat paw oedema.
Topics: Ajmaline; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Carbon Radioisotopes; Carrageenan; Edema; Humans; Indomethacin; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Rats; Shock | 1993 |
Mast cell-mediated colonic immune function and its inhibition by dietary aspirin in mice infected with Trichinella spiralis.
Topics: Animals; Antigens, Helminth; Arachidonic Acid; Aspirin; Biogenic Amines; Colon; Intestinal Mucosa; Ion Transport; Male; Mast Cells; Mice; Mice, Inbred Strains; Trichinella spiralis; Trichinellosis | 1994 |
Influence of various doses of aspirin (in vivo) on platelet arachidonic acid metabolism (ex vivo) and function.
Topics: Adenosine Triphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Epinephrine; Humans; In Vitro Techniques; Platelet Aggregation; Tablets, Enteric-Coated | 1994 |
Dysfunctional recovery of prostacyclin synthase in aspirin-treated vascular cells: implications for prophylaxis of cardiovascular disease.
Topics: Arachidonic Acid; Aspirin; Cardiovascular Diseases; Cell Line; Cytochrome P-450 Enzyme System; Epoprostenol; Intramolecular Oxidoreductases; Isomerases; Muscle, Smooth, Vascular; Thrombin | 1994 |
Development of aspirin resistance in persons with previous ischemic stroke.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Brain Ischemia; Cerebrovascular Disorders; Cohort Studies; Collagen; Dose-Response Relationship, Drug; Drug Resistance; Drug Tolerance; Epinephrine; Female; Follow-Up Studies; Humans; Intracranial Embolism and Thrombosis; Male; Platelet Aggregation; Recurrence | 1994 |
Induction of cyclooxygenase by interleukin 1: comparative study between human synovial cells and chondrocytes.
Topics: Arachidonic Acid; Aspirin; Cartilage; Cells, Cultured; Cyclophosphamide; Dactinomycin; Dinoprostone; Enzyme Induction; Humans; Interleukin-1; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Biosynthesis; Recombinant Proteins; Synovial Membrane; Transcription, Genetic | 1994 |
Prevention by acetylsalicylic acid of liver cirrhosis and carcinogenesis as well as generations of 8-hydroxydeoxyguanosine and thiobarbituric acid-reactive substances caused by a choline-deficient, L-amino acid-defined diet in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amino Acids; Animals; Arachidonic Acid; Aspirin; Choline Deficiency; Deoxyguanosine; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred F344; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances | 1994 |
Possible involvement of arachidonic acid and eicosanoids in metamorphic events in Hydractinia echinata (Coelenterata; Hydrozoa).
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Aspirin; Carbon Radioisotopes; Eicosanoids; Gas Chromatography-Mass Spectrometry; Hydra; Hydroxyeicosatetraenoic Acids; Indomethacin; Lipoxygenase; Masoprocol; Metamorphosis, Biological; Phospholipids | 1994 |
Two distinct mechanisms of inhibition of platelets aggregation by acetylsalicylic acid.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Humans; Phospholipases A; Platelet Aggregation; Platelet Aggregation Inhibitors; Ristocetin; Thromboxane A2; von Willebrand Factor | 1994 |
Effect of picotamide on the calcium mobilization and phospholipase C activation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Chromatography, Gel; Enzyme Activation; Humans; In Vitro Techniques; Phthalic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptors, Thromboxane; Thrombin; Thromboxane A2; Type C Phospholipases | 1994 |
Protective effects of KW-3635, a thromboxane A2 antagonist, on arachidonic acid-induced transient cerebral ischemia in dogs.
Topics: Animals; Arachidonic Acid; Aspirin; Benzimidazoles; Benzoxepins; Blood Pressure; Carotid Arteries; Cerebrovascular Circulation; Dogs; Electroencephalography; Female; Heart Rate; In Vitro Techniques; Injections, Intra-Arterial; Ischemic Attack, Transient; Male; Platelet Aggregation; Thromboxane A2 | 1994 |
Effect of single oral dose of aspirin on human platelet functions and plasma plasminogen activator inhibitor-1.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Epinephrine; Female; Fibrinogen; Humans; In Vitro Techniques; Male; Plasminogen Activator Inhibitor 1; Platelet Aggregation; Time Factors | 1993 |
[Effect of Y-20811, a thromboxane A2 synthetase inhibitor, on the arachidonic acid-induced response in the blood-superfused canine coronary artery].
Topics: Animals; Arachidonic Acid; Arteries; Aspirin; Coronary Vessels; Dogs; Endothelium, Vascular; Imidazoles; In Vitro Techniques; Thromboxane-A Synthase; Vasoconstriction | 1994 |
Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Base Sequence; Cell Line; Chromatography, High Pressure Liquid; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Humans; Hydroxyeicosatetraenoic Acids; Immunoblotting; Microsomes; Molecular Sequence Data; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Vaccinia virus | 1994 |
Inhibitory effect of KW-3635, a new thromboxane A2-receptor antagonist, on arterial thrombosis in guinea pigs.
Topics: Animals; Arachidonic Acid; Aspirin; Benzimidazoles; Benzoxepins; Collagen; Disease Models, Animal; Femoral Artery; Guinea Pigs; Male; Phenylacetates; Platelet Aggregation; Sulfonamides; Thrombosis; Thromboxane A2 | 1993 |
In vitro and ex vivo effects of aspirin in patients on a low-dose aspirin therapy.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Collagen; Coronary Disease; Humans; Middle Aged; Platelet Aggregation; Thromboxane B2 | 1993 |
Triterpenes and B-sitosterol from piper betle: isolation, antiplatelet and anti-inflammatory effects.
Topics: Adenosine Diphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Areca; Aspirin; Chromatography, Liquid; Edema; Humans; Plants, Medicinal; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Sitosterols; Triterpenes | 1993 |
Age-dependent modifications of the role of prostanoids in cardiac preparations from normotensive and hypertensive rats.
Topics: Age Factors; Animals; Arachidonic Acid; Aspirin; Heart; Hypertension; In Vitro Techniques; Norepinephrine; Prostaglandins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sympathetic Nervous System | 1993 |
[Effect of quercetin on chemiluminescence of human platelets induced by arachidonic acid].
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Drug Synergism; Free Radical Scavengers; Humans; Luminescent Measurements; Mannitol; Quercetin; Superoxide Dismutase | 1993 |
The distribution and taxonomic value of fatty acids and eicosanoids in the Lipomycetaceae and Dipodascaceae.
Topics: Arachidonic Acid; Aspirin; Chromatography, Thin Layer; Dinoprost; Dinoprostone; Eicosanoids; Fatty Acids; Gas Chromatography-Mass Spectrometry; Radioimmunoassay; Saccharomycetales; Spores, Fungal; Ubiquinone | 1993 |
Tumor necrosis factor alpha stimulates amnion prostaglandin biosynthesis primarily via an action on fatty acid cyclooxygenase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Arachidonic Acid; Aspirin; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Female; Humans; Isoquinolines; Piperazines; Pregnancy; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1993 |
Modulation of rat and human lymphocyte function by n-6 and n-3 polyunsaturated fatty acids and acetylsalicylic acid.
Topics: Animals; Arachidonic Acid; Aspirin; Cells, Cultured; Concanavalin A; Drug Interactions; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Fish Oils; Humans; Killer Cells, Natural; Linseed Oil; Lymphocyte Activation; Lymphocytes; Male; Phytohemagglutinins; Rats; Rats, Wistar; Spleen | 1993 |
Reduction by arachidonic acid of prostaglandin I2-induced cyclic AMP formation. Involvement of prostaglandins E2 and F2 alpha.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Colforsin; Cyclic AMP; Dinoprost; Dinoprostone; Drug Interactions; Epoprostenol; Humans; Pentanoic Acids; Platelet Aggregation; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Pyridines; Thromboxane B2 | 1993 |
Effects of eicosanoid metabolism inhibitors on growth of a human gastric tumour cell line (HGT).
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonic Acid; Aspirin; Cell Division; Eicosanoids; Fatty Acids; Humans; Masoprocol; Membrane Lipids; Phospholipids; Stomach Neoplasms; Tumor Cells, Cultured | 1993 |
Effect of aspirin on coronary collateral blood flow.
Topics: Animals; Arachidonic Acid; Aspirin; Collateral Circulation; Coronary Circulation; Cyclooxygenase Inhibitors; Dogs; Female; Hemodynamics; Male; Nitroglycerin | 1993 |
Inhibitory effects of inhibitors of arachidonic acid metabolism on the evolution of rat liver preneoplastic foci into nodules and hepatocellular carcinomas with or without phenobarbital exposure.
Topics: Acetophenones; Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Diethylnitrosamine; Lipoxygenase Inhibitors; Liver Neoplasms, Experimental; Male; Phenobarbital; Phospholipases A; Phospholipases A2; Precancerous Conditions; Quercetin; Rats; Rats, Inbred F344 | 1993 |
Thin layer chromatographic identification of thromboxane B2 in serum, and platelet rich plasma stimulated by arachidonic acid and collagen.
Topics: Adult; Arachidonic Acid; Aspirin; Blood Platelets; Chromatography, Thin Layer; Collagen; Female; Humans; Male; Middle Aged; Platelet Count; Thromboxane B2 | 1993 |
The differential effect of aspirin on human platelet activation in aspirin-sensitive asthmatics and normal subjects.
Topics: Adenosine Triphosphate; Adult; Analysis of Variance; Arachidonic Acid; Aspirin; Asthma; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Humans; In Vitro Techniques; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Regression Analysis | 1993 |
Vanadate activates platelets by enhancing arachidonic acid release.
Topics: Arachidonic Acid; Aspirin; Autoradiography; Blood Platelets; Blood Proteins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Humans; In Vitro Techniques; Kinetics; Microscopy, Electron; Molecular Weight; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Platelet Activation; Platelet Aggregation; Saponins; Vanadates | 1993 |
Redirection of arachidonic acid metabolism by ICI D1542: effects on thrombus formation in the coronary artery of the anaesthetized dog.
Topics: Anesthesia; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Blood Pressure; Coronary Circulation; Coronary Thrombosis; Dioxanes; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Endothelium, Vascular; Epinephrine; Heart Rate; Pyridines; Receptors, Thromboxane; Thromboxane-A Synthase | 1993 |
Aspirin, interleukin-3 and the antiphospholipid syndrome.
Topics: Animals; Antiphospholipid Syndrome; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Female; Humans; Interleukin-3; Mice; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy Complications | 1996 |
Effect of KBT-3022, a new diphenylthiazole derivative, on platelet functions.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Edema; Erythema; Gastric Mucosa; Guinea Pigs; Humans; Mice; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Rats; Serotonin; Species Specificity; Thiazoles; Thrombin; Ultraviolet Rays | 1995 |
Antiaggregating and vasodilatory effects of a new nitroderivative of acetylsalicylic acid.
Topics: Adult; Animals; Aorta, Thoracic; Arachidonic Acid; Aspirin; Female; Humans; Muscle, Smooth, Vascular; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thrombin; Thromboxane A2; Vasodilation | 1995 |
Interaction of substance P with epidermal growth factor and fibroblast growth factor in cyclooxygenase-dependent proliferation of human skin fibroblasts.
Topics: Animals; Arachidonic Acid; Aspirin; Cattle; Cell Division; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Humans; Leukotriene B4; Prostaglandin-Endoperoxide Synthases; Skin; Substance P | 1996 |
Low concentrations of nonsteroidal anti-inflammatory drugs affect cell functions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Dose-Response Relationship, Drug; Ibuprofen; Lymphocyte Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred CBA | 1995 |
Prostacyclin production at the human microvascular anastomosis: its effect on initial platelet deposition.
Topics: Anastomosis, Surgical; Arachidonic Acid; Aspirin; Endothelium, Vascular; Epoprostenol; Humans; Microsurgery; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis | 1996 |
Cyclooxygenase-1 and -2 of endothelial cells utilize exogenous or endogenous arachidonic acid for transcellular production of thromboxane.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Cell Communication; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Endothelium, Vascular; Humans; Isoenzymes; Membrane Proteins; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Thrombin; Thromboxanes | 1996 |
Potentiation of myeloid differentiation by anti-inflammatory agents, by steroids and by retinoic acid involves a single intracellular target, probably an enzyme of the aldoketoreductase family.
Topics: 3-Hydroxysteroid Dehydrogenases; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cell Differentiation; Cholecalciferol; Dexamethasone; Dihydrotestosterone; Down-Regulation; Estradiol; HL-60 Cells; Humans; Indomethacin; Medroxyprogesterone; Monocytes; Naphthol AS D Esterase; Neutrophils; Nitroblue Tetrazolium; Prostaglandins; Tretinoin | 1996 |
Effect of KBT-3022, a new cyclooxygenase inhibitor, on experimental brain edema in vitro and in vivo.
Topics: Animals; Arachidonic Acid; Aspirin; Brain; Brain Edema; Brain Ischemia; Cyclooxygenase Inhibitors; Gerbillinae; Guinea Pigs; In Vitro Techniques; Indomethacin; Lipid Peroxidation; Male; Pyrroles; Thiazoles | 1996 |
Suppression of the hypersensitive response in potato by acetyl salicylic acid.
Topics: Antifungal Agents; Arachidonic Acid; Aspirin; Eicosapentaenoic Acid; Phytophthora; Plant Diseases; Solanum tuberosum; Terpenes | 1996 |
In vitro study of the anti-aggregating activity of two nitroderivatives of acetylsalicylic acid.
Topics: Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2; Thromboxane B2 | 1996 |
Platelet reactivity in vitro in relation to thromboxane in healthy pregnancy.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adolescent; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cross-Sectional Studies; Cyclic AMP; Dioxanes; Female; Humans; Imidazoles; Platelet Aggregation; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Thromboxane-A Synthase | 1996 |
Inhibition of arachidonic acid induced-aggregation of rabbit platelets with CV-4151 (isbogrel), a selective thromboxane A2 (TXA2) synthase inhibitor: modulation of the antiplatelet action and prostanoid metabolism by rat aortic rings.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Arachidonic Acid; Aspirin; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Epoprostenol; Fatty Acids, Monounsaturated; In Vitro Techniques; Intramolecular Oxidoreductases; Isomerases; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; Thromboxane A2; Thromboxane-A Synthase | 1996 |
Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls.
Topics: Animals; Arachidonic Acid; Aroclors; Aspirin; Cyclooxygenase Inhibitors; Hydroxyurea; In Vitro Techniques; Lipoxygenase Inhibitors; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phospholipases A; Phospholipases A2; Polychlorinated Biphenyls; Quinacrine; Rats; Superoxides; Terpenes; Tetradecanoylphorbol Acetate | 1996 |
Differential expression of platelet activation markers in aspirin-sensitive asthmatics and normal subjects.
Topics: Adult; Antigens, CD; Arachidonic Acid; Aspirin; Asthma; Blood Platelets; Cell Adhesion Molecules; Collagen; Drug Hypersensitivity; Drug Interactions; Female; Flow Cytometry; Humans; Male; Middle Aged; P-Selectin; Platelet Activating Factor; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Tetraspanin 30 | 1996 |
Albumin prevents metabolism of 12-hydroxyeicosatetraenoic acid by leukocytes in vitro.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Aspirin; Blood Platelets; Calcimycin; Calcium; Carrier Proteins; Chromatography, High Pressure Liquid; Coculture Techniques; Depression, Chemical; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fatty Acids; Humans; Ionophores; Leukocytes; Myelin P2 Protein; Neoplasm Proteins; Platelet Activation; Serum Albumin; Tumor Suppressor Proteins | 1996 |
The efficacy and potency of antiplatelet activity of ticlopidine is increased by aspirin.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Collagen; Drug Synergism; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 1996 |
Taurine and diabetes. Humans and experimental models.
Topics: Animals; Arachidonic Acid; Aspirin; Blood Platelets; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Food, Fortified; Humans; Male; Platelet Aggregation; Rats; Rats, Wistar; Retina; Taurine | 1996 |
Arachidonic acid up-regulates and prostaglandin E2 down-regulates the expression of pancreatic-type phospholipase A2 and prostaglandin-endoperoxide synthase 2 in uterine stromal cells.
Topics: Animals; Arachidonic Acid; Aspirin; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Meclofenamic Acid; Oxytocics; Phospholipases A; Phospholipases A2; Rats; Stromal Cells; Up-Regulation; Uterus | 1996 |
Altered sensitivity of aspirin-acetylated prostaglandin G/H synthase-2 to inhibition by nonsteroidal anti-inflammatory drugs.
Topics: Acetylation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; COS Cells; Cyclooxygenase Inhibitors; Dinoprostone; Hydroxyeicosatetraenoic Acids; Prostaglandin-Endoperoxide Synthases | 1997 |
Mechanism of the contractile effect of diaspirin-cross-linked hemoglobin in rat isolated aorta strip denuded of endothelium as revealed using an oil-immersion procedure.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antioxidants; Aorta, Thoracic; Arachidonic Acid; Aspirin; Blood Substitutes; Cytological Techniques; Endothelium, Vascular; Hemoglobins; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Sprague-Dawley; Thromboxane A2; Vasoconstrictor Agents | 1996 |
Differential inhibition of murine prostaglandin synthase-1 and -2 by nonsteroidal anti-inflammatory drugs using exogenous and endogenous sources of arachidonic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Calcimycin; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Indomethacin; Isoenzymes; Kinetics; Membrane Proteins; Mice; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 1997 |
Role of kinases and G-proteins on arachidonate release induced by zymosan in mouse peritoneal macrophages.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Aspirin; Cells, Cultured; GTP-Binding Proteins; Macrophages, Peritoneal; Male; Mice; Neomycin; Pertussis Toxin; Phagocytosis; Phosphotransferases; Virulence Factors, Bordetella; Zymosan | 1996 |
Effects of U73122 and U73343 on human platelet calcium signalling and protein tyrosine phosphorylation.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Blood Proteins; Calcium; Collagen; Estrenes; Humans; Phosphodiesterase Inhibitors; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pyrrolidinones; Signal Transduction; Thapsigargin; Thrombin; Thromboxane A2; Type C Phospholipases | 1997 |
Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2.
Topics: Arachidonic Acid; Aspirin; Cyclooxygenase 2; Electron Spin Resonance Spectroscopy; Enzyme Activation; Free Radicals; Humans; Hydrogen Peroxide; Isoenzymes; Kinetics; Lipoxygenase; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Stereoisomerism; Tetranitromethane; Tyrosine | 1997 |
Cell-cell interaction between platelets and IL-1 beta-stimulated vascular smooth muscle cells in synthesis of thromboxane A2.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Cell Communication; Cells, Cultured; Coculture Techniques; Cycloheximide; Dactinomycin; Humans; Interleukin-1; Muscle, Smooth, Vascular; Phospholipids; Prostaglandin Endoperoxides; Prostaglandin H2; Prostaglandins H; Rats; Recombinant Proteins; Thrombin; Thromboxane A2 | 1997 |
Effects of aspirin and garlic on cyclooxygenase-induced chemiluminescence in human term placenta.
Topics: alpha-Linolenic Acid; Arachidonic Acid; Aspirin; Chorionic Villi; Cyclooxygenase Inhibitors; Female; Garlic; Humans; Linoleic Acid; Linoleic Acids; Luminescent Measurements; Plant Extracts; Plants, Medicinal; Pregnancy; Prostaglandin-Endoperoxide Synthases | 1997 |
Long-term renal preservation and prevention of acute tubular necrosis by inhibition of arachidonate metabolism.
Topics: Adenosine; Allopurinol; Animals; Arachidonic Acid; Aspirin; Benzofurans; Dogs; Enzyme Inhibitors; Female; Glutathione; Ibuprofen; Imidazoles; Insulin; Kidney Transplantation; Kidney Tubular Necrosis, Acute; Kidney Tubules; Leukotriene Antagonists; Leukotrienes; Organ Preservation; Organ Preservation Solutions; Pyridines; Raffinose; Thromboxane-A Synthase | 1995 |
Detection of an Fe2+-protoporphyrin-IX intermediate during aspirin-treated prostaglandin H2 synthase II catalysis of arachidonic acid to 15-HETE.
Topics: Arachidonic Acid; Aspirin; Catalysis; Cyclooxygenase Inhibitors; Ferrous Compounds; Humans; Hydrogen Peroxide; Hydroxyeicosatetraenoic Acids; Isoenzymes; Kinetics; Oxygen Consumption; Prostaglandin-Endoperoxide Synthases; Protoporphyrins; Recombinant Proteins; Spectrum Analysis | 1997 |
The potent inhibition of vapiprost, a novel thromboxane A2 receptor antagonist, on the secondary aggregation and ATP release of human platelets.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Aspirin; Biphenyl Compounds; Blood Platelets; Guinea Pigs; Heptanoic Acids; Humans; Male; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Rabbits; Rats; Rats, Wistar; Receptors, Thromboxane; Species Specificity; Thromboxane A2 | 1997 |
Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Deferoxamine; Enzyme Activation; Fatty Acids, Unsaturated; Humans; Hydrazines; Hydrogen Peroxide; Leukotrienes; Lipid Peroxides; Oligopeptides; Peroxides; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; tert-Butylhydroperoxide; Thromboxane B2; Vitamin E | 1997 |
Regulation of macrophage cytokine production by prostaglandin E2. Distinct roles of cyclooxygenase-1 and -2.
Topics: Animals; Arachidonic Acid; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Dinoprostone; Interleukin-1; Interleukin-6; Isoenzymes; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Mice, Inbred BALB C; Prostaglandin-Endoperoxide Synthases; Serum Albumin; Serum Albumin, Human; Tumor Necrosis Factor-alpha | 1997 |
Flow- and agonist-mediated nitric oxide- and prostaglandin-dependent dilation in spinal arteries.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arteries; Aspirin; Dinoprostone; Endothelium, Vascular; Epoprostenol; In Vitro Techniques; Indomethacin; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pressure; Prostaglandins; Prostaglandins, Synthetic; Rabbits; Spine; Vasodilation | 1997 |
The painless synergism of aspirin and opium.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Brain; Drug Synergism; In Vitro Techniques; Lipoxygenase; Opium; Periaqueductal Gray; Prostaglandin-Endoperoxide Synthases; Receptors, GABA; Receptors, Opioid, mu | 1997 |
How opioids inhibit GABA-mediated neurotransmission.
Topics: Animals; Arachidonate 12-Lipoxygenase; Arachidonic Acid; Aspirin; Baclofen; Enkephalin, Methionine; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Narcotics; Periaqueductal Gray; Phospholipases A; Phospholipases A2; Potassium; Potassium Channel Blockers; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Opioid, mu; Second Messenger Systems; Synapses; Synaptic Transmission | 1997 |
Different substrate utilization between prostaglandin endoperoxide H synthase-1 and -2 in NIH3T3 fibroblasts.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antioxidants; Arachidonic Acid; Aspirin; Azoles; Calcimycin; Cell Cycle; Cyclooxygenase 1; Cyclooxygenase 2; Immunohistochemistry; Ionophores; Isoenzymes; Isoindoles; Kinetics; Lipid Peroxides; Membrane Proteins; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Organoselenium Compounds; Prostaglandin-Endoperoxide Synthases; Sodium Selenite; Substrate Specificity | 1998 |
Methacholine-induced contraction of rabbit pulmonary artery: role of platelet-endothelial transcellular thromboxane synthesis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Endothelium, Vascular; In Vitro Techniques; Male; Methacholine Chloride; Models, Cardiovascular; Muscle Contraction; Muscle, Smooth, Vascular; Pulmonary Artery; Rabbits; Thromboxane A2; Vasoconstriction | 1998 |
Hemoglobin A0 and alpha-crosslinked hemoglobin (alpha-DBBF) potentiate agonist-induced platelet aggregation through the platelet thromboxane receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Aspirin; Blood Platelets; Blood Substitutes; Collagen; Drug Synergism; Heme; Hemoglobin A; Humans; Membrane Proteins; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Second Messenger Systems; Thrombin | 1998 |
Antioxidants diminish developmental damage induced by high glucose and cyclooxygenase inhibitors in rat embryos in vitro.
Topics: Acetylcysteine; Animals; Antioxidants; Arachidonic Acid; Aspirin; Culture Techniques; Cyclooxygenase Inhibitors; Dinoprostone; Embryo, Mammalian; Embryonic and Fetal Development; Glucose; Indomethacin; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase | 1998 |
Increased arachidonic acid induced platelet chemiluminescence indicates cyclooxygenase overactivity in schizophrenic subjects.
Topics: Adult; Antipsychotic Agents; Arachidonic Acid; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Activation; Female; Humans; Linoleic Acid; Luminescent Measurements; Male; Prostaglandin-Endoperoxide Synthases; Schizophrenia; Sulpiride; Time Factors | 1998 |
[In vitro study of the mechanism of the platelet anti-aggregant action of picotamide (G 137)].
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Humans; Malondialdehyde; Molecular Structure; Phthalic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Structure-Activity Relationship; Thromboxane A2; Thromboxane-A Synthase | 1983 |
Inhibition of platelet-vessel wall interactions by thromboxane receptor antagonism in a human in vitro system: potentiation of antiplatelet effects of aspirin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Aspirin; Blood Platelets; Carbazoles; Drug Synergism; Endothelium, Vascular; Humans; In Vitro Techniques; Perfusion; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thromboxane; Sulfonamides | 1998 |
Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents.
Topics: Animals; Anticarcinogenic Agents; Arachidonic Acid; Aspirin; Body Weight; Carcinogens; Drug Screening Assays, Antitumor; Female; Hydroxyurea; Indoles; Lipoxygenase Inhibitors; Lung Neoplasms; Mice; Mice, Inbred A; Neoplasms, Experimental; Nitrosamines | 1998 |
Effects of arachidonic acid metabolism on hypoxic vasoconstriction in rabbit lungs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Drug Interactions; Female; Hypoxia; Indoles; Lipoxygenase Inhibitors; Lung; Male; Masoprocol; Rabbits; Vasoconstriction | 1998 |
Effect of aspirin on prostaglandin E2 and leukotriene B4 production in human colonic mucosa from cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Arachidonic Acid; Aspirin; Colon; Colonic Neoplasms; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; Intestinal Mucosa; Leukotriene B4; Lipoxygenase; Male; Middle Aged | 1997 |
Modes of action of aspirin-like drugs: salicylates inhibit erk activation and integrin-dependent neutrophil adhesion.
Topics: Acetaminophen; Antigens, CD; Arachidonic Acid; Aspirin; Calcium-Calmodulin-Dependent Protein Kinases; CD18 Antigens; Cell Adhesion; Cell Aggregation; Cell Survival; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Macrophage-1 Antigen; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Sodium Salicylate; Tetradecanoylphorbol Acetate | 1998 |
Effects of copper-aspirin complex on platelet aggregation and thrombosis in rabbits and mice.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Aspirin; Copper; Drug Combinations; Female; In Vitro Techniques; Intubation, Gastrointestinal; Male; Mice; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Radioimmunoassay; Random Allocation; Thrombosis; Thromboxane B2 | 1998 |
Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets.
Topics: Arachidonic Acid; Aspirin; Biphenyl Compounds; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Electrophoresis, Polyacrylamide Gel; Fatty Acids, Unsaturated; Heptanoic Acids; Humans; Hydrazines; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Protein Kinase C; Receptors, Thromboxane; Thrombin; Thromboxane A2 | 1999 |
Inhibition of platelet aggregation by S-nitroso-cysteine via cGMP-independent mechanisms: evidence of inhibition of thromboxane A2 synthesis in human blood platelets.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Cyclic GMP; Cysteine; Fatty Acids, Unsaturated; Glutathione; Guanylate Cyclase; Humans; Hydrazines; Inhibitory Concentration 50; Nitric Oxide; Nitrites; Nitroprusside; Nitroso Compounds; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines; S-Nitrosoglutathione; S-Nitrosothiols; Thromboxane A2 | 1999 |
Evidence of a cyclooxygenase-related prostaglandin synthesis in coral. The allene oxide pathway is not involved in prostaglandin biosynthesis.
Topics: Alkadienes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cnidaria; Gas Chromatography-Mass Spectrometry; Indomethacin; Leukotrienes; Magnetic Resonance Spectroscopy; ortho-Aminobenzoates; Oxides; Prostaglandin-Endoperoxide Synthases; Prostaglandins | 1999 |
Inhibitory effect of sulfur-containing compounds in Scorodocarpus borneensis Becc. on the aggregation of rabbit platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Coagulation Factors; Collagen; Hemostatics; Hexanes; Inhibitory Concentration 50; Octanes; Plant Extracts; Plants, Edible; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Sulfur Compounds; Thrombin; Trees; Vasoconstrictor Agents | 1999 |
Arachidonic acid-induced hind limb gangrene: a new experimental rat model of peripheral vascular disease.
Topics: Animals; Arachidonic Acid; Aspirin; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Femoral Artery; Gangrene; Hindlimb; Injections, Intra-Arterial; Male; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Ticlopidine; Vascular Diseases | 1999 |
Arachidonic acid metabolism in nasal tissue and peripheral blood cells in aspirin intolerant asthmatics.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Asthma; Bronchial Provocation Tests; Case-Control Studies; Dinoprostone; Drug Hypersensitivity; Female; Humans; Leukotrienes; Male; Nasal Mucosa; Nasal Polyps; Neoplasm Recurrence, Local | 1999 |
Oxidative damage in fetal rat brain induced by ischemia and subsequent reperfusion. Relation to arachidonic acid peroxidation.
Topics: Animals; Arachidonic Acid; Aspirin; Brain; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Fetal Diseases; Ischemic Attack, Transient; Lipid Peroxidation; Lipoxygenase Inhibitors; Mitochondria; Oxidative Stress; Oxygen Consumption; Pregnancy; Pyrazoles; Rats; Rats, Wistar; Reperfusion Injury; Thiobarbituric Acid Reactive Substances | 1999 |
Inhibitory effects of H2-receptor antagonists on platelet function in vitro.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cimetidine; Collagen; Famotidine; Female; Heterocyclic Compounds, 1-Ring; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Middle Aged; P-Selectin; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Ranitidine; Structure-Activity Relationship | 1999 |
Anti-platelet aggregation activity of stilbene derivatives from Rheum undulatum.
Topics: Animals; Arachidonic Acid; Aspirin; Collagen; In Vitro Techniques; Plants, Medicinal; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rheum; Stilbenes | 1999 |
Intestinal tumor load in the Min/+ mouse model is not correlated with eicosanoid biosynthesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Dinoprostone; Eicosanoids; Genes, APC; Indomethacin; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mutation; Sulindac | 1999 |
Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site.
Topics: Acetylation; Arachidonic Acid; Aspirin; Binding Sites; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Hydrogen; Hydroxyeicosatetraenoic Acids; Isoenzymes; Models, Chemical; Prostaglandin-Endoperoxide Synthases; Substrate Specificity | 2000 |
Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients.
Topics: Adult; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Asthma; Cattle; Cells, Cultured; Dinoprostone; Drug Hypersensitivity; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Middle Aged; Nasal Polyps; Prostaglandin D2; Respiratory Mucosa | 2000 |
Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete.
Topics: Acetylation; Animals; Arachidonic Acid; Aspirin; Binding Sites; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Hydroxyeicosatetraenoic Acids; Isoenzymes; Membrane Proteins; Mice; Models, Molecular; Mutagenesis, Site-Directed; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Spodoptera | 2000 |
Characteristics of collagen-induced Ca2+ mobilization in bovine platelets.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Cattle; Collagen; Egtazic Acid; Enzyme Inhibitors; Estrenes; Fluorescent Dyes; Fura-2; Humans; Manganese; Phosphoadenosine Phosphosulfate; Platelet Aggregation Inhibitors; Pyrrolidinones; Thapsigargin; Thrombin; Type C Phospholipases | 2000 |
Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Aspirin; Drug Interactions; Endocannabinoids; Enzyme Inhibitors; Lipoxygenase; Phenylmethylsulfonyl Fluoride; Platelet Aggregation; Polyunsaturated Alkamides; Prostaglandin-Endoperoxide Synthases; Rabbits; Tritium | 2000 |
Even low-dose aspirin inhibits arachidonic acid-induced vasodilation in heart failure.
Topics: Adult; Aged; Arachidonic Acid; Aspirin; Brachial Artery; Case-Control Studies; Dose-Response Relationship, Drug; Female; Heart Failure; Humans; Male; Platelet Aggregation Inhibitors; Plethysmography; Vasodilation | 2000 |
Inhibition by unsaturated fatty acids of type II secretory phospholipase A2 synthesis in guinea-pig alveolar macrophages evidence for the eicosanoid-independent pathway.
Topics: Animals; Arachidonic Acid; Aspirin; Benzeneacetamides; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Group II Phospholipases A2; Guinea Pigs; Hydroxamic Acids; Inhibitory Concentration 50; Lipoxygenase; Lipoxygenase Inhibitors; Macrophages, Alveolar; Male; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Triazoles; Tumor Necrosis Factor-alpha | 2000 |
Discordant effect of aspirin and indomethacin on intestinal tumor burden in Apc(Min/+)mice.
Topics: 6-Ketoprostaglandin F1 alpha; Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arachidonic Acid; Aspirin; Body Weight; Dinoprostone; Eating; Indomethacin; Intestinal Mucosa; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Prostaglandin Antagonists | 2000 |
Differential regulation of prostaglandin E2 and thromboxane A2 production in human monocytes: implications for the use of cyclooxygenase inhibitors.
Topics: Arachidonic Acid; Aspirin; Cell Fractionation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Eicosanoids; Enzyme Induction; Humans; Interphase; Isoenzymes; Kinetics; Lipopolysaccharides; Membrane Proteins; Monocytes; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Thromboxane A2; Thromboxane-A Synthase; U937 Cells; Zymosan | 2000 |
Effect of aspirin on platelet desaggregation induced by SR121566, a potent GP-IIb/IIIa antagonist.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Benzylamines; Blood Flow Velocity; Blood Platelets; Carotid Arteries; Disease Models, Animal; Electric Stimulation; Female; Fibrinolytic Agents; Humans; Male; Oligopeptides; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Recombinant Proteins; Thiazoles; Thrombosis; Thrombospondins; Tissue Plasminogen Activator | 2000 |
Defective platelet response to arachidonic acid and thromboxane A(2) in subjects with Pl(A2) polymorphism of beta(3) subunit (glycoprotein IIIa).
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; beta-Thromboglobulin; Blood Platelets; Coronary Disease; Female; Flow Cytometry; Genotype; Humans; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Risk Factors; Statistics, Nonparametric; Thrombin; Thromboxane A2 | 2000 |
Adrenaline potentiates type 2B von Willebrand factor-induced activation of human platelets by enhancing both the formation and action of thromboxanes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Antagonists; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Drug Synergism; Epinephrine; Humans; Kinetics; Lipoxygenase; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Prostanoic Acids; Serotonin; Sympathomimetics; Thromboxanes; Tyrosine; Vasoconstrictor Agents; von Willebrand Factor; Yohimbine | 2000 |
Influence of insulin on the metabolism of glucose in uteri isolated from ovariectomized and non ovariectomized underfed rats.
Topics: Amenorrhea; Animals; Arachidonic Acid; Arginine; Aspirin; Diestrus; Dose-Response Relationship, Drug; Eicosanoids; Energy Metabolism; Enzyme Inhibitors; Female; Food Deprivation; Glucose; Hemoglobins; Insulin; Myometrium; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; omega-N-Methylarginine; Ovariectomy; Rats; Rats, Wistar; Uterus | 2000 |
A combination of lactacystin and 12-O-tetradecanoylphorbol-13-acetate enhances the release of arachidonic acid from cells in cultures: release is reduced in confluent and serum deprived cells.
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Cattle; Cell Division; Cells, Cultured; Contact Inhibition; Culture Media; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dexamethasone; Drug Synergism; Endothelium, Vascular; Enzyme Inhibitors; Gliotoxin; Group IV Phospholipases A2; Hepatocytes; Immunosuppressive Agents; Multienzyme Complexes; Muscle, Smooth, Vascular; Neuroglia; Organophosphonates; Phospholipases A; Phospholipases A2; Proteasome Endopeptidase Complex; Pulmonary Artery; Rats; Sodium Salicylate; Tetradecanoylphorbol Acetate | 2000 |
Abciximab treatment in vitro after aspirin treatment in vivo has additive effects on platelet aggregation, ATP release, and P-selectin expression.
Topics: Abciximab; Adenosine Diphosphate; Adenosine Triphosphate; Adult; Antibodies, Monoclonal; Arachidonic Acid; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors | 2000 |
Effect of sodium arachidonate on thrombin generation through platelet activation--inhibitory effect of aspirin.
Topics: Adult; Aged; Arachidonic Acid; Area Under Curve; Aspirin; Female; Humans; Kinetics; Male; Middle Aged; Platelet Activation; Thrombin | 2000 |
Aspirin promotes TFF2 gene activation in human gastric cancer cell lines.
Topics: Arachidonic Acid; Aspirin; Gastrointestinal Neoplasms; Genes, Reporter; Growth Substances; Humans; Indomethacin; Models, Biological; Mucins; Muscle Proteins; Neuropeptides; Peptides; Protein Kinase C; Response Elements; RNA, Messenger; Sequence Deletion; Signal Transduction; Staurosporine; Transcriptional Activation; Transfection; Trefoil Factor-2; Trefoil Factor-3; Tumor Cells, Cultured | 2001 |
Prostaglandin H synthase-2 inhibitors interfere with prostaglandin H synthase-1 inhibition by nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cattle; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Ibuprofen; Indomethacin; Isoenzymes; Male; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sulfonamides; Thiophenes | 2001 |
Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas.
Topics: Adenocarcinoma; Adrenergic beta-Antagonists; Arachidonic Acid; Aspirin; Base Sequence; DNA Primers; Enzyme Inhibitors; Genes, ras; Humans; Indoles; Pancreatic Neoplasms; Propanolamines; Radioligand Assay; Receptors, Adrenergic, beta; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2001 |
Individual dosing of ASA prophylaxis by controlling platelet aggregation.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombophilia | 2001 |
Effects of selective cyclooxygenase-2 inhibition on vascular responses and thrombosis in canine coronary arteries.
Topics: Acetylcholine; Animals; Arachidonic Acid; Aspirin; Benzofurans; Blood Flow Velocity; Celecoxib; Coronary Circulation; Coronary Thrombosis; Coronary Vessels; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Epoprostenol; Isoenzymes; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thromboxane-A Synthase; Time Factors; Vasodilation; Vasomotor System | 2001 |
Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Apoptosis; Arachidonic Acid; Aspirin; Biomarkers; Cardiomyopathies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Doxorubicin; Enzyme Induction; Epoprostenol; Heart; Iloprost; Isoenzymes; L-Lactate Dehydrogenase; Male; Membrane Proteins; Myocardium; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sulfonamides; Thromboxane B2; Transcription Factors; Troponin T | 2001 |
Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation.
Topics: Adult; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Catechols; Fatty Alcohols; Humans; Inhibitory Concentration 50; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Serotonin; Solubility; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Antiapoptotic effect of dipyrone on HL-60, Jurkat and Raji cell lines submitted to UV irradiation, arachidonic acid and cycloheximide treatments.
Topics: Analgesics; Analgesics, Non-Narcotic; Apoptosis; Arachidonic Acid; Aspirin; B-Lymphocytes; Cycloheximide; Cyclooxygenase Inhibitors; Dipyrone; DNA Fragmentation; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Jurkat Cells; Leukemia, B-Cell; Neoplasm Proteins; Parasympatholytics; Poly(ADP-ribose) Polymerases; Protein Synthesis Inhibitors; Radiation-Protective Agents; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2001 |
Epinephrine--via activation of p38-MAPK--abolishes the effect of aspirin on platelet deposition to collagen.
Topics: Adult; Antigens, Human Platelet; Arachidonic Acid; Aspirin; Blood Platelets; Collagen Type I; Drug Interactions; Enzyme Inhibitors; Epinephrine; Humans; Middle Aged; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Adhesiveness | 2001 |
Regulation of cyclooxygenase activity and progesterone production in the rat corpus luteum by inducible nitric oxide synthase.
Topics: Animals; Arachidonic Acid; Aspirin; Cells, Cultured; Corpus Luteum; Cyclooxygenase Inhibitors; Depression, Chemical; Enzyme Inhibitors; Female; Gonadotropins, Equine; Indomethacin; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; omega-N-Methylarginine; Progesterone; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Rats; Rats, Inbred Strains | 2002 |
Platelet-erythrocyte interactions enhance alpha(IIb)beta(3) integrin receptor activation and P-selectin expression during platelet recruitment: down-regulation by aspirin ex vivo.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Cytosol; Erythrocytes; Humans; In Vitro Techniques; Ionomycin; P-Selectin; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Vasoconstrictor Agents | 2002 |
Evaluation of the effects of anti-thromboxane agents in platelet-vessel wall interaction.
Topics: Animals; Aorta, Thoracic; Arachidonic Acid; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cell Communication; Dinoprost; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Male; Methacrylates; Muscle Tonus; Muscle, Smooth, Vascular; Phthalic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Rabbits; Receptors, Thromboxane; Thromboxane A2; Thromboxane-A Synthase | 2002 |
Beta-adrenergic and arachidonic acid-mediated growth regulation of human breast cancer cell lines.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Aspirin; Breast Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; DNA; DNA Replication; Enzyme Inhibitors; Estrogens; Female; Humans; Isoenzymes; Isoproterenol; Lipoxygenase Inhibitors; Membrane Proteins; Neoplasms, Hormone-Dependent; Prostaglandin-Endoperoxide Synthases; Receptors, Adrenergic, beta-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2002 |
Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica.
Topics: Adenosine Diphosphate; Alkaloids; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Diterpenes; Female; Fibrinolytic Agents; Ginkgolides; In Vitro Techniques; Indicators and Reagents; Lactones; Male; Plant Extracts; Plant Roots; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Spiraea | 2002 |
Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2.
Topics: Animals; Arachidonic Acid; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hydrogen Peroxide; Isoenzymes; Magnetics; Membrane Proteins; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Sheep; Tyrosine | 2002 |
Decrease in efficacy and potency of nonsteroidal anti-inflammatory drugs by chronic delta(9)-tetrahydrocannabinol administration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Aspirin; Camphanes; Diclofenac; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanolamines; Indomethacin; Kinetics; Male; Mice; Mice, Inbred ICR; Pain; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug | 2002 |
Aspirin (ASA) regulates 5-lipoxygenase activity and peroxisome proliferator-activated receptor alpha-mediated CINC-1 release in rat liver cells: novel actions of lipoxin A4 (LXA4) and ASA-triggered 15-epi-LXA4.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Aspirin; Chemokine CXCL1; Chemokines; Chemokines, CXC; Chemotactic Factors; Dinoprostone; Hepatocytes; Hydroxyeicosatetraenoic Acids; Intercellular Signaling Peptides and Proteins; Kupffer Cells; Leukotriene B4; Lipoxins; Liver; Models, Biological; Rats; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2002 |
On the interaction of specific prostaglandin H synthase-2 inhibitors with prostaglandin H synthase-1.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Binding, Competitive; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ibuprofen; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep; Sulfonamides | 2002 |
Uncoupled regulation of leukotriene C4 synthase in platelets from aspirin-intolerant asthmatics and healthy volunteers after aspirin treatment.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Asthma; Blood Platelets; Case-Control Studies; Collagen; Depression, Chemical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glutathione Transferase; Humans; Male; Middle Aged; Thromboxane A2 | 2002 |
Antiplatelet activity of synthetic pyrrolo-benzylisoquinolines.
Topics: Adrenergic Antagonists; Animals; Arachidonic Acid; Aspirin; Benzyl Compounds; Collagen; Guinea Pigs; Humans; Inhibitory Concentration 50; Isoquinolines; Platelet Aggregation; Platelet Aggregation Inhibitors; Propanolamines; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
The stable analog carbocyclic TXA2 but not platelet-released TXA2 induces osteoclast-like cell formation.
Topics: Acid Phosphatase; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Bone Marrow Cells; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Cell Nucleus; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Hydrazines; Indomethacin; Membrane Glycoproteins; Mice; Nitrobenzenes; Osteoclasts; Prostaglandin-Endoperoxide Synthases; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Stromal Cells; Sulfonamides; Tartrates; Thromboxane A2 | 2003 |
Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation.
Topics: Animals; Arachidonic Acid; Aspirin; Dose-Response Relationship, Drug; Drug Combinations; Drugs, Chinese Herbal; Femoral Artery; Fibrinolytic Agents; Flavonoids; Hippophae; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Platelet Aggregation; Thrombosis | 2003 |
Synergistic effect of D-003 and aspirin on experimental thrombosis models.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Aspirin; Death, Sudden; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fatty Acids; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thrombosis; Thromboxane B2 | 2003 |
Osteoblast-derived oxysterol is a migration-inducing factor for human breast cancer cells.
Topics: Arachidonic Acid; Aspirin; Breast Neoplasms; Cell Membrane; Cell Movement; Cholesterol; Chromatography, High Pressure Liquid; Coculture Techniques; Culture Media, Conditioned; Dinoprostone; Electrophoresis, Polyacrylamide Gel; HSP70 Heat-Shock Proteins; Humans; Insulin-Like Growth Factor I; Lipid Metabolism; Lovastatin; MAP Kinase Signaling System; Microscopy, Fluorescence; Neoplasm Metastasis; Osteoblasts; Phospholipids; Phosphorylation; Prostaglandins B; Protein Transport; Proto-Oncogene Proteins p21(ras); Reverse Transcriptase Polymerase Chain Reaction; Sepharose; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingolipids; Sterols; Trypsin; Tumor Cells, Cultured | 2003 |
Obesity is associated with impaired platelet-inhibitory effect of acetylsalicylic acid in nondiabetic subjects.
Topics: Adenosine Diphosphate; Analysis of Variance; Arachidonic Acid; Arteriosclerosis; Aspirin; Blood Glucose; Body Mass Index; Body Weight; Dose-Response Relationship, Drug; Female; Humans; Insulin Resistance; Male; Middle Aged; Obesity; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors | 2003 |
Antiplatelet activity of benzylisoquinoline derivatives oxidized by cerium(IV) ammonium nitrate.
Topics: Arachidonic Acid; Aspirin; Benzylisoquinolines; Cerium; Collagen; Nitrates; Oxidation-Reduction; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Structure-Activity Relationship; Thrombin | 2003 |
Relationship of arachidonic acid concentration to cyclooxygenase-dependent human platelet aggregation.
Topics: Adolescent; Adult; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Drug Administration Schedule; Drug Interactions; Female; Humans; Male; Middle Aged; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Reproducibility of Results | 2003 |
Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angelica; Animals; Arachidonic Acid; Aspirin; Benzopyrans; Blood Platelets; Butyrates; Collagen; Coumarins; Furocoumarins; Glucosides; Herbal Medicine; Heterocyclic Compounds, 3-Ring; Korea; Male; Medicine, East Asian Traditional; Methanol; Nephelometry and Turbidimetry; Plant Extracts; Plant Roots; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley | 2003 |
Single oral dose study of two isosorbide-based aspirin prodrugs in the dog.
Topics: Administration, Oral; Animals; Arachidonic Acid; Aspirin; Collagen; Dogs; Female; Isosorbide; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests | 2003 |
Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Cells, Cultured; Cyclooxygenase 1; Dose-Response Relationship, Drug; Humans; Isoenzymes; Membrane Proteins; Phenols; Plant Extracts; Platelet Activation; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Zingiber officinale | 2003 |
Cyclooxygenase inhibition is associated with downregulation of apolipoprotein AI promoter activity in cultured hepatoma cell line HepG2.
Topics: Apolipoprotein A-I; Arachidonic Acid; Aspirin; Blotting, Northern; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Down-Regulation; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Isoenzymes; Liver Neoplasms; Membrane Proteins; Plasmids; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Prostaglandins; RNA, Messenger; Thromboxane B2; Transcription, Genetic | 2004 |
Mutations within the cyclooxygenase-1 gene in aspirin non-responders with recurrence of stroke.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Case-Control Studies; Cyclooxygenase 1; DNA Mutational Analysis; Drug Resistance; Family Health; Female; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; Models, Molecular; Mutation, Missense; Pharmacogenetics; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Recurrence; Stroke | 2003 |
Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation.
Topics: Acetates; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Epinephrine; Humans; In Vitro Techniques; Isoenzymes; Lipoxygenase Inhibitors; Membrane Proteins; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyrroles; Quinolines; Thrombin; Thromboxane B2 | 2004 |
Evaluation of effects of rofecoxib on platelet function in an in vitro model of thrombosis with circulating human blood.
Topics: Adenosine Diphosphate; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Cell Adhesion; Collagen; Cyclooxygenase Inhibitors; Endothelium; Humans; Lactones; Platelet Aggregation; Sulfones; Thrombosis | 2004 |
Evaluation of anti-platelet aggregatory effects of aspirin, cilostazol and ramatroban on platelet-rich plasma and whole blood.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Carbazoles; Cilostazol; Collagen; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclooxygenase Inhibitors; Humans; Microscopy, Confocal; Phosphodiesterase Inhibitors; Plasma; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thromboxane A2, Prostaglandin H2; Reproducibility of Results; Sulfonamides; Tetrazoles | 2004 |
Inhibition of the arachidonic acid metabolism blocks endothelial cell migration and induces apoptosis.
Topics: Apoptosis; Arachidonic Acid; Aspirin; Benzofurans; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Cyclooxygenase Inhibitors; Endothelial Cells; Humans; Imidazoles; Neuroglia; Thromboxane-A Synthase | 2004 |
Platelet inhibition by aspirin is diminished in patients during carotid surgery: a form of transient aspirin resistance?
Topics: Aged; Aged, 80 and over; Angioplasty; Arachidonic Acid; Aspirin; Blood Platelets; Case-Control Studies; Cohort Studies; Cyclooxygenase Inhibitors; Drug Resistance; Endarterectomy, Carotid; Female; Humans; In Vitro Techniques; Leg; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation; Platelet Count; Prospective Studies; Stroke; Thrombosis | 2004 |
gp91phox-dependent expression of platelet CD40 ligand.
Topics: Adult; Antioxidants; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Catalase; CD40 Ligand; Collagen; Granulomatous Disease, Chronic; Humans; Male; Mannitol; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Phospholipases A; Phospholipases A2; Platelet Activation; Platelet Aggregation Inhibitors; Reactive Oxygen Species; Superoxide Dismutase; Superoxides; Thrombin | 2004 |
Aspirin "allergy" and resistance.
Topics: Arachidonic Acid; Aspirin; Drug Hypersensitivity; Drug Resistance; Humans | 2004 |
Arachidonic acid reduces the stress response of gilthead seabream Sparus aurata L.
Topics: Analysis of Variance; Animals; Aquaculture; Arachidonic Acid; Aspirin; Chlorides; Confined Spaces; Diet; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids; Female; Gills; Kidney; Male; Sea Bream; Sodium; Sodium-Potassium-Exchanging ATPase; Stress, Physiological; Water-Electrolyte Balance | 2004 |
Role of the Pyk2-MAP kinase-cPLA2 signaling pathway in shear-dependent platelet aggregation.
Topics: Acetyltransferases; Arachidonic Acid; Aspirin; Blood Platelets; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Kinase 2; Humans; Mechanotransduction, Cellular; Platelet Aggregation; Protein-Tyrosine Kinases; Shear Strength; Signal Transduction; Stress, Mechanical; Transcription Factors | 2004 |
Dietary supplementation with arachidonic acid in tilapia (Oreochromis mossambicus) reveals physiological effects not mediated by prostaglandins.
Topics: Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Diet; Dietary Supplements; Dinoprostone; Drug Synergism; Female; Gills; Hydrocortisone; Kidney; Male; Prostaglandins; Restraint, Physical; Sodium-Potassium-Exchanging ATPase; Stress, Physiological; Tilapia | 2004 |
Synthesis of baicalein derivatives as potential anti-aggregatory and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cell Line; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Flavanones; Lipopolysaccharides; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Taiwan; Technology, Pharmaceutical | 2005 |
Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition.
Topics: Animals; Arachidonic Acid; Aspirin; Blood Platelets; Cyclooxygenase 1; Edema; Estradiol; Female; Humans; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovary; Parturition; Pre-Eclampsia; Pregnancy; Progesterone; Prostaglandin-Endoperoxide Synthases; Receptors, Oxytocin; Thromboxane A2; Uterus | 2005 |
Specific effect of arachidonic acid on inducible nitric oxide synthase mRNA expression in human osteoblastic cells.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Arachidonic Acid; Aspirin; Cell Line, Tumor; Cyclooxygenase Inhibitors; Cytokines; Eicosapentaenoic Acid; Enzyme Activation; Genistein; Humans; Naphthalenes; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oleic Acid; Osteoblasts; Protein Kinase C; Protein-Tyrosine Kinases; RNA, Messenger | 2005 |
Assessment of the antiplatelet effects of low to medium dose aspirin in the early and late phases after ischaemic stroke and TIA.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Case-Control Studies; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Epinephrine; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandin-Endoperoxide Synthases; Stroke; von Willebrand Factor | 2005 |
A new point-of-care method for monitoring anti-platelet therapy: application of the cone and plate(let) analyzer.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Proteins; Drug Monitoring; Humans; Membrane Proteins; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Sensitivity and Specificity | 2005 |
Abciximab does not inhibit the increase of thrombin generation produced in platelet-rich plasma in vitro by sodium arachidonate or tissue factor.
Topics: Abciximab; Adult; Aged; Antibodies, Monoclonal; Arachidonic Acid; Aspirin; Blood Platelets; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Aggregation Inhibitors; Reference Values; Thrombin; Thromboplastin | 2005 |
A Thrombelastograph whole blood assay for clinical monitoring of NSAID-insensitive transcellular platelet activation by arachidonic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Celecoxib; Dose-Response Relationship, Drug; Humans; Ibuprofen; Platelet Activation; Platelet Aggregation; Pyrazoles; Sulfonamides; Thrombelastography | 2005 |
Antiplatelet property of Curcuma longa L. rhizome-derived ar-turmerone.
Topics: Animals; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Curcuma; Hexanes; Inhibitory Concentration 50; Ketones; Plant Extracts; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rhizome; Sesquiterpenes; Toluene | 2006 |
Cyclooxygenase-1 haplotype modulates platelet response to aspirin.
Topics: Adult; Arachidonic Acid; Aspirin; Cardiovascular Diseases; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Resistance; Female; Haplotypes; Humans; Likelihood Functions; Male; Pharmacogenetics; Platelet Aggregation; Polymorphism, Single Nucleotide; Prospective Studies; Thromboxane A2 | 2005 |
Abnormal eicosanoid-pattern of peripheral white-blood cells in gastro-intestinal cancer.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Case-Control Studies; Cyclooxygenase Inhibitors; Dinoprostone; Female; Gastrointestinal Neoplasms; Humans; Immunoenzyme Techniques; Leukocytes; Leukotrienes; Male; Middle Aged | 2005 |
Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulation.
Topics: Adult; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Postoperative Complications; Prevalence; Prospective Studies; Reproducibility of Results; Stents; Thrombelastography; Thrombosis | 2005 |
Enhancement of Ca2+-regulated exocytosis by indomethacin in guinea-pig antral mucous cells: arachidonic acid accumulation.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium Signaling; Cells, Cultured; Cinnamates; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Exocytosis; Gastric Mucosa; Guinea Pigs; Indomethacin; Isoquinolines; Male; ortho-Aminobenzoates; Phospholipases A; Phospholipases A2; Pyloric Antrum; Sulfonamides; Time Factors | 2006 |
Platelet emboli and ischemia in rabbit's brain caused by ADP or arachidonic acid and the protective effect of ASA and dipyridamole.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Dipyridamole; Intracranial Embolism; Ischemic Attack, Transient; Male; Pia Mater; Platelet Aggregation; Rabbits | 1977 |
Effects of different aspirin formulations on platelet aggregation times and on plasma salicylate concentrations.
Topics: Administration, Oral; Adolescent; Adult; Arachidonic Acid; Aspirin; Cross-Over Studies; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Reference Values; Salicylates; Single-Blind Method; Solubility; Tablets, Enteric-Coated; Time Factors | 2006 |
2-(2-Br-phenyl)-8-methoxy-benzoxazinone (HPW-RX2), a direct thrombin inhibitor with a suppressive effect on thromboxane formation in platelets.
Topics: Adenosine Triphosphate; Arachidonic Acid; Aspirin; Benzoxazines; Blood Platelets; Calcium; Calcium Signaling; Collagen; Dose-Response Relationship, Drug; Humans; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin D2; Receptors, Thrombin; Thrombin; Thromboxane A2; Thromboxane B2 | 2005 |
Biological basis and clinical implications of acetylsalicylic acid resistance.
Topics: Acetylation; Acetyltransferases; Arachidonic Acid; Aspirin; Drug Resistance; Fibrinolytic Agents; Humans; Myocardial Infarction; Platelet Activating Factor; Prostaglandin-Endoperoxide Synthases; Stroke; Thromboxane A2 | 2006 |
Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Coronary Artery Disease; Cyclooxygenase 1; Diabetes Mellitus; Female; Genotype; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Membrane Glycoproteins; Polymorphism, Single Nucleotide; Sex Factors; Thromboxane B2 | 2006 |
Dose- and time-dependent antiplatelet effects of aspirin.
Topics: Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cross-Over Studies; Dose-Response Relationship, Drug; Epoprostenol; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Thromboxanes; Time Factors | 2006 |
Thromboxane mediates neutrophil superoxide production in pregnancy.
Topics: Arachidonic Acid; Aspirin; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Humans; Indomethacin; Neutrophils; Nitrobenzenes; Phospholipases A; Phospholipases A2; Pregnancy; Sulfonamides; Superoxides; Thromboxane-A Synthase; Thromboxanes | 2006 |
Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases.
Topics: Animals; Arachidonic Acid; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Fish Proteins; Gas Chromatography-Mass Spectrometry; Humans; Male; Peroxides; Sheep; Species Specificity; Substrate Specificity; Temperature; Trout | 2006 |
Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Clopidogrel; Coronary Artery Disease; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Resistance; Female; Flow Cytometry; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Signal Transduction; Thrombosis; Thromboxane B2; Ticlopidine; Time Factors; Treatment Refusal | 2006 |
Prostaglandin E2 release in gastric antral mucosa of guinea-pigs: basal PGE2 release by cyclo-oxygenase 2 and ACh-stimulated PGE2 release by cyclo-oxygenase 1.
Topics: Acetylcholine; Animals; Arachidonic Acid; Aspirin; Calcium; Cinnamates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Guinea Pigs; Indomethacin; Ionomycin; Male; Nitrobenzenes; ortho-Aminobenzoates; Phospholipases A; Pyloric Antrum; Pyrazoles; Sulfonamides | 2006 |
Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Coronary Artery Disease; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Thromboxane B2; Whole Blood Coagulation Time | 2006 |
Prostacyclin therapy increases right ventricular capillarisation in a model for flow-associated pulmonary hypertension.
Topics: Animals; Arachidonic Acid; Aspirin; Blood Pressure; Capillaries; Disease Models, Animal; Echocardiography; Gene Expression; Heart Ventricles; Hypertension, Pulmonary; Iloprost; Lung; Male; Myocardium; Organ Size; Platelet Aggregation Inhibitors; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar; Receptors, Vascular Endothelial Growth Factor; Survival Rate; Vascular Endothelial Growth Factor A; Ventricular Remodeling | 2006 |
Effects on primary haemostasis of an anti-inflammatory agent with 5-lipoxygenase and cyclooxygenase inhibitory activity.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Hemostasis; Humans; Lipoxygenase Inhibitors; Platelet Aggregation; Pyrroles; Rabbits | 2006 |
Comparison of a rapid platelet function assay--Verify Now Aspirin--with whole blood impedance aggregometry for the detection of aspirin resistance.
Topics: Adult; Aged; Arachidonic Acid; Aspirin; Drug Resistance; Electric Impedance; Female; Fibrinogen; Humans; Male; Microspheres; Middle Aged; Photometry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems | 2007 |
Letter by Kronish et al regarding article, "Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance".
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Coronary Disease; Cyclooxygenase 1; Cyclooxygenase 2; Drug Resistance; Humans; Patient Compliance; Platelet Activation; Reproducibility of Results | 2007 |
Eicosanoids, aspirin-intolerance and the upper airways--current standards and recent improvements of the desensitization therapy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Asthma; Clinical Trials as Topic; Desensitization, Immunologic; Drug Hypersensitivity; Eicosanoids; Humans; Nasal Polyps; Respiratory System | 2006 |
Testing and typing of eicosanoid-patterns.
Topics: Adult; Aged; Analgesics; Arachidonic Acid; Aspirin; Dinoprostone; Eicosanoids; Female; Humans; Inflammation; Leukocytes; Leukotrienes; Male; Middle Aged; Models, Biological; Signal Transduction; Time Factors | 2006 |
Assessing aspirin-induced attenuation of platelet reactivity by flow cytometry.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Atherosclerosis; Blood Platelets; Case-Control Studies; Cyclooxygenase Inhibitors; Drug Resistance; Female; Flow Cytometry; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Function Tests; Prostaglandin-Endoperoxide Synthases | 2007 |
Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1.
Topics: Adult; Arachidonic Acid; Aspirin; beta-Thromboglobulin; Black or African American; Blood Platelets; Cardiovascular Diseases; Coronary Disease; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Resistance; Dyslipidemias; Female; Genetic Heterogeneity; Genetic Predisposition to Disease; Genetic Variation; Humans; Hyperglycemia; Hypertension; Male; Membrane Proteins; Middle Aged; Phenotype; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Sex Characteristics; Smoking; Thrombophilia; Thrombosis; Thromboxane B2; White People | 2007 |
[Interindividual variability in the laboratory response to the aspirin-clopidogrel combination: are patients with stent occlusion "resistant" to treatment?].
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Coronary Restenosis; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Ticlopidine | 2007 |
Heritability, platelet function, and aspirin: a link established but cause unknown.
Topics: Arachidonic Acid; Aspirin; Black or African American; Blood Platelets; Cardiovascular Diseases; Cyclooxygenase 1; Female; Genetic Heterogeneity; Genetic Predisposition to Disease; Genetic Variation; Humans; Male; Membrane Proteins; Phenotype; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Sex Characteristics; Thrombophilia; Thrombosis; Thromboxanes; White People | 2007 |
Aspirin resistance among long-term aspirin users after carotid endarterectomy and controls: flow cytometric measurement of aspirin-induced platelet inhibition.
Topics: Aged; Arachidonic Acid; Aspirin; Blood Platelets; Carotid Stenosis; Case-Control Studies; Cyclooxygenase Inhibitors; Drug Resistance; Endarterectomy, Carotid; Female; Fibrinolytic Agents; Flow Cytometry; Humans; Male; P-Selectin; Platelet Function Tests; Prostaglandin-Endoperoxide Synthases; Severity of Illness Index | 2007 |
Residual platelet reactivity is associated with clinical and laboratory characteristics in patients with ischemic heart disease undergoing PCI on dual antiplatelet therapy.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Myocardial Ischemia; Platelet Aggregation Inhibitors; Protein Isoforms; Risk Factors; Ticlopidine | 2007 |
Comparison of different methods to evaluate the effect of aspirin on platelet function in high-risk patients with ischemic heart disease receiving dual antiplatelet treatment.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Sensitivity and Specificity; Ticlopidine | 2007 |
[Modified platelet aggregation test in patients on ASA and/or clopidogrel].
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epinephrine; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Thrombosis; Ticlopidine | 2007 |
Predominant basal directional release of thromboxane, but not prostacyclin, by placental trophoblasts from normal and preeclamptic pregnancies.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arachidonic Acid; Aspirin; Epoprostenol; Female; Humans; Placenta; Pre-Eclampsia; Pregnancy; Receptors, Thromboxane; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes; Trophoblasts; Vasoconstriction | 2008 |
Flow cytometric assessment of platelet aspirin resistance using light scattering.
Topics: Arachidonic Acid; Aspirin; Biological Assay; Buffers; Drug Resistance; Flow Cytometry; Humans; Light; Platelet Aggregation Inhibitors; Platelet Count; Predictive Value of Tests; Reproducibility of Results; Scattering, Radiation | 2008 |
Standardization of light transmittance aggregometry for monitoring antiplatelet therapy: an adjustment for platelet count is not necessary.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Algorithms; Arachidonic Acid; Aspirin; Calibration; Clopidogrel; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Platelet-Rich Plasma; Sensitivity and Specificity; Thrombophilia; Ticlopidine | 2008 |
Comment on "hyperresponsiveness of platelets in ischemic stroke" by Fateh-Moghadam et al.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Biomarkers; Blood Platelets; Brain Ischemia; Epinephrine; Humans; Ischemic Attack, Transient; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Recurrence; Stroke; Time Factors | 2008 |
Apigenin inhibits platelet adhesion and thrombus formation and synergizes with aspirin in the suppression of the arachidonic acid pathway.
Topics: Apigenin; Arachidonic Acid; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Drug Synergism; Endothelium; Fatty Acids, Unsaturated; Humans; Hydrazines; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet-Rich Plasma; Receptors, Thromboxane A2, Prostaglandin H2; Thrombosis | 2008 |
Aspirin non-responsiveness in Korean subjects on dual anti-platelet treatment determined by two different platelet function assays.
Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Asian People; Aspirin; Bleeding Time; Case-Control Studies; Clopidogrel; Collagen; Drug Resistance; Epinephrine; Female; Humans; Korea; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2008 |
Relationship between aspirin and clopidogrel responses in acute coronary syndrome and clinical predictors of non response.
Topics: Acute Coronary Syndrome; Age Factors; Aged; Arachidonic Acid; Aspirin; Body Mass Index; Cell Adhesion Molecules; Clopidogrel; Diabetes Complications; Drug Resistance; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Effect of inhibitors of arachidonic acid conversion in platelets on thrombin-fibrinogen interaction and thrombin tolerance.
Topics: Animals; Arachidonic Acid; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Fibrinogen; Imidazoles; Male; Platelet Aggregation; Quinacrine; Rats; Thrombin | 2007 |
Multiple anti-atherosclerotic treatments impair aspirin compliance: effects on aspirin resistance.
Topics: Arachidonic Acid; Aspirin; Atherosclerosis; Drug Resistance; Drug Therapy, Combination; Humans; Patient Compliance; Platelet Activation; Thromboxane A2 | 2008 |
Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Drug Resistance; Humans; Platelet Aggregation; Thrombosis; Thromboxane A2 | 2008 |
Selenium status in patients with aspirin-induced asthma.
Topics: Adult; Aged; Antioxidants; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Aspirin; Asthma; Female; Free Radicals; Humans; Leukotriene B4; Leukotrienes; Macrophages; Male; Middle Aged; Selenium | 2008 |
An evaluation of cyclooxygenase-1 inhibition before coronary artery surgery: aggregometry versus patient self-reporting.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Coronary Artery Bypass; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Erythrocyte Transfusion; Female; Humans; Male; Middle Aged; Platelet Aggregation; Prospective Studies | 2008 |
Predicting thrombotic events: creating a complex approach for a complex condition.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Reproducibility of Results; Risk Assessment; Risk Factors; ROC Curve; Thrombosis; Ticlopidine | 2008 |
Evaluation of the platelet count drop method for assessment of platelet function in comparison with "gold standard" light transmission aggregometry.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Reproducibility of Results; Ticlopidine | 2009 |
Native platelet aggregation and response to aspirin in persons with the metabolic syndrome and its components.
Topics: Adult; Arachidonic Acid; Aspirin; Collagen; Coronary Artery Disease; Female; Guidelines as Topic; Humans; Male; Metabolic Syndrome; Middle Aged; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors | 2009 |
Metabolic profile of plasma free fatty acids in patients with aspirin-intolerant urticaria.
Topics: Adolescent; Adult; Arachidonic Acid; Aspirin; Fatty Acids; Fatty Acids, Monounsaturated; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Female; Humans; Lipid Metabolism; Male; Middle Aged; Urticaria | 2009 |
The impact of intravenous aspirin administration on platelet aspirin resistance after on-pump coronary artery bypass surgery.
Topics: Adenosine Diphosphate; Administration, Oral; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Collagen; Coronary Artery Bypass; Drug Resistance; Female; Humans; Injections, Intravenous; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests | 2009 |
Variability in aggregometry response before and after initiation of clopidogrel therapy.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Case-Control Studies; Clopidogrel; Demography; Female; Humans; Male; Middle Aged; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reproducibility of Results; Ticlopidine | 2009 |
The formation of monocyte-platelet aggregates is independent of on-treatment residual agonists'-inducible platelet reactivity.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Lipopolysaccharide Receptors; Male; Microfilament Proteins; Middle Aged; Monocytes; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Stents; Ticlopidine | 2009 |
Interactions of gallic acid, resveratrol, quercetin and aspirin at the platelet cyclooxygenase-1 level. Functional and modelling studies.
Topics: Animals; Antioxidants; Arachidonic Acid; Aspirin; Blood Platelets; Cyclooxygenase 1; Drug Interactions; Gallic Acid; Humans; In Vitro Techniques; Male; Membrane Proteins; Mice; Models, Biological; Models, Molecular; Platelet Aggregation; Platelet Aggregation Inhibitors; Quercetin; Reactive Oxygen Species; Resveratrol; Stilbenes; Thermodynamics | 2009 |
Predictive value of post-treatment platelet reactivity for occurrence of post-discharge bleeding after non-ST elevation acute coronary syndrome. Shifting from antiplatelet resistance to bleeding risk assessment?
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Biomarkers; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Intracranial Hemorrhages; Male; Microfilament Proteins; Middle Aged; Patient Discharge; Phosphoproteins; Phosphorylation; Pilot Projects; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Risk Assessment; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Low dose aspirin depresses human platelet aggregation triggered by activating agents whose mechanisms involve arachidonic acid.
Topics: Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Humans; Male; Platelet Aggregation | 2005 |
Effects of clopidogrel on "aspirin specific" pathways of platelet inhibition.
Topics: Adenosine Diphosphate; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Drug Interactions; Female; Humans; Male; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Aspirin; Benzoates; Blood Pressure; Dose-Response Relationship, Drug; Enzyme Activation; Epoxide Hydrolases; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Indoles; Inflammation; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Prostaglandin-Endoperoxide Synthases; Urea | 2010 |
Aspirin, arachidonic acid and the regulation of mood.
Topics: Affect; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Arachidonic Acid; Aspirin; Bipolar Disorder; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Glucocorticoids; Humans; Lithium | 2010 |
Post interventional cardiology urinary thromboxane correlates with PlateletMapping detected aspirin resistance.
Topics: Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Arachidonic Acid; Aspirin; Blood Platelets; Cardiology; Humans; Platelet Activation; Platelet Count; Thromboxane B2 | 2010 |
Platelet function recovery after cessation of aspirin: preliminary study of volunteers and surgical patients.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Coagulation; Blood Platelets; Case-Control Studies; Drug Administration Schedule; Elective Surgical Procedures; Epinephrine; Female; Humans; International Normalized Ratio; Longitudinal Studies; Male; Middle Aged; Partial Thromboplastin Time; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Recovery of Function; Thromboxane B2; Time Factors; Young Adult | 2010 |
Prothrombinase formation at the site of microvascular injury and aspirin resistance: the effect of simvastatin.
Topics: Arachidonic Acid; Aspirin; Bleeding Time; Drug Combinations; Drug Resistance; Factor X; Fasting; Humans; Male; Middle Aged; Outpatients; Platelet Aggregation; Simvastatin; Thromboplastin; Time Factors; Wounds and Injuries | 2010 |
Asymmetric acetylation of the cyclooxygenase-2 homodimer by aspirin and its effects on the oxygenation of arachidonic, eicosapentaenoic, and docosahexaenoic acids.
Topics: Acetylation; Arachidonic Acid; Aspirin; Base Sequence; Chromatography, Liquid; Chromatography, Thin Layer; Cyclooxygenase 2; Diclofenac; Dimerization; DNA Primers; Docosahexaenoic Acids; Eicosapentaenoic Acid; Humans; Mutagenesis; Oxygen; Tandem Mass Spectrometry | 2010 |
Evaluation of antiplatelet effects of a modified protocol by platelet aggregation in patients undergoing "one-stop" hybrid coronary revascularization.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Artery Bypass; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; Ticlopidine | 2010 |
The N-terminus of COX-1 and its effect on cyclooxygenase-1 catalytic activity.
Topics: Animals; Arachidonic Acid; Aspirin; Biocatalysis; Blotting, Western; Cell Line; Chlorocebus aethiops; CHO Cells; COS Cells; Cricetinae; Cricetulus; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Humans; Kinetics; Mutant Proteins; Mutation; Transfection | 2010 |
A comparison of platelet function tests and thromboxane metabolites to evaluate aspirin response in healthy individuals and patients with coronary artery disease.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Cells, Cultured; Collagen; Coronary Artery Disease; Cyclooxygenase 1; Drug Resistance; Enzyme Inhibitors; Epinephrine; Platelet Activation; Reproducibility of Results; Sensitivity and Specificity; Thromboxanes | 2010 |
Effect of obesity on platelet reactivity and response to low-dose aspirin.
Topics: Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cardiovascular Diseases; Case-Control Studies; Collagen; Drug Resistance; Female; Humans; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Obesity; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Time Factors | 2010 |
Cytosolic phospholipase A2alpha mediates Pseudomonas aeruginosa LPS-induced airway constriction of CFTR -/- mice.
Topics: Administration, Intranasal; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Chemokine CXCL2; Cyclooxygenase Inhibitors; Cystic Fibrosis; Dinoprostone; Disease Models, Animal; Enzyme Inhibitors; Group IV Phospholipases A2; Leukotrienes; Lipopolysaccharides; Lung; Mice; Mice, Inbred CFTR; Mice, Knockout; Neutrophil Infiltration; Pneumonia; Pseudomonas aeruginosa; Time Factors | 2010 |
Peroxisome proliferation activation receptor alpha modulation of Ca2+-regulated exocytosis via arachidonic acid in guinea-pig antral mucous cells.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Exocytosis; Gastric Mucosa; Guinea Pigs; Indoles; Indomethacin; Male; PPAR alpha; Pyloric Antrum; Pyrimidines; Thapsigargin | 2010 |
Platelet activation patterns in platelet size sub-populations: differential responses to aspirin in vitro.
Topics: Acid Phosphatase; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Cell Size; Cells, Cultured; Fibrinogen; Humans; Isoenzymes; P-Selectin; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Tartrate-Resistant Acid Phosphatase; Thromboxane B2; von Willebrand Factor | 2010 |
Evaluation of platelet function and pharmacological platelet inhibition in patients with myeloproliferative disorders using multiple electrode aggregometry.
Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Austria; Case-Control Studies; Clopidogrel; Electrodes; Female; Humans; Linear Models; Male; Middle Aged; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polycythemia Vera; Predictive Value of Tests; Reproducibility of Results; Thrombocythemia, Essential; Thrombosis; Ticlopidine; Treatment Outcome; Young Adult | 2010 |
Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes.
Topics: Acetaminophen; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Cell Line, Tumor; Cyclooxygenase Inhibitors; Dinoprostone; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen Peroxide; Mice; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Salicylic Acid; Thromboxane B2 | 2010 |
Synthesis and biological activities of transition metal complexes based on acetylsalicylic acid as neo-anticancer agents.
Topics: Alkynes; Antineoplastic Agents; Apoptosis; Arachidonic Acid; Aspirin; Butadienes; Cell Line, Tumor; Cell Proliferation; Cobalt; Coordination Complexes; Cyclooxygenase Inhibitors; Dinoprostone; Drug Screening Assays, Antitumor; Humans; Iron; Ruthenium; Stereoisomerism; Structure-Activity Relationship | 2010 |
Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Biomarkers; Blood Platelets; Case-Control Studies; Chi-Square Distribution; Collagen; Coronary Artery Disease; Denmark; Diabetes Mellitus, Type 2; Female; Humans; Linear Models; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Registries; Risk Assessment; Risk Factors; Smoking; Thrombopoietin; Thromboxane B2 | 2011 |
Clopidogrel discontinuation and platelet reactivity following coronary stenting.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Epinephrine; Female; Humans; Ireland; Male; Middle Aged; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Anti-inflammatory effects of chronic aspirin on brain arachidonic acid metabolites.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Brain; Dinoprostone; Humans; Leukotriene B4; Lipopolysaccharides; Lipoxins; Male; Rats; Rats, Inbred F344; Thromboxane B2 | 2011 |
Inconsistency of different methods for assessing ex vivo platelet function: relevance for the detection of aspirin resistance.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane B2; Young Adult | 2010 |
Why an aspirin a day no longer keeps the doctor away ….
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Coronary Artery Disease; Drug Administration Schedule; Drug Monitoring; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Thromboxane A2; Time Factors; Treatment Outcome | 2011 |
24-hour time-dependent aspirin efficacy in patients with stable coronary artery disease.
Topics: Aged; Arachidonic Acid; Aspirin; Blood Platelets; Chi-Square Distribution; Coronary Artery Disease; Drug Administration Schedule; Drug Monitoring; Drug Resistance; Female; Humans; Male; Middle Aged; Odds Ratio; Paris; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Thromboxane A2; Time Factors; Treatment Outcome | 2011 |
In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Aspirin; Collagen; Drug Synergism; Epinephrine; Humans; In Vitro Techniques; Peptide Fragments; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thromboxane A2 | 2011 |
Cardiovascular effects of low-dose aspirin, traditional non-steroidal anti-inflammatory drugs and coxibs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Cardiovascular Diseases; Cardiovascular System; Cyclooxygenase 2 Inhibitors; Endothelium, Vascular; Humans | 2010 |
Relation of aspirin failure to clinical outcome and to platelet response to aspirin in patients with acute myocardial infarction.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Drug Resistance; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Function Tests; Risk Factors; Treatment Failure | 2011 |
Residual cyclooxygenase-1 activity and epinephrine reduce the antiplatelet effect of aspirin in patients with acute myocardial infarction.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Platelets; Calcium Signaling; Cells, Cultured; Cyclooxygenase 1; Drug Interactions; Epinephrine; Female; Humans; Male; Middle Aged; Myocardial Infarction; Phosphatidylinositol 3-Kinases; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2 | 2011 |
Aspirin failure in patients presenting with acute cerebrovascular ischaemia.
Topics: Acute Disease; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Brain Ischemia; Drug Resistance; Female; Humans; Male; P-Selectin; Patient Compliance; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane B2 | 2011 |
Short-term exposure of platelets to glucose impairs inhibition of platelet aggregation by cyclooxygenase inhibitors.
Topics: Acetaminophen; Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cells, Cultured; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Glucose; Humans; Indomethacin; Lactic Acid; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet-Rich Plasma | 2011 |
Protocatechualdehyde synergizes with aspirin at the platelet cyclooxygenase-1 level.
Topics: Animals; Anticoagulants; Antioxidants; Arachidonic Acid; Aspirin; Benzaldehydes; Blood Platelets; Caffeic Acids; Catechols; Cyclooxygenase 1; Drug Synergism; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Binding; Rabbits | 2011 |
Inhibitory effects of 1,3-bis-(2-substituted-phenyl)-propane-1,3-dione, β-diketone structural analogues of curcumin, on chemical-induced tumor promotion and inflammation in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Aspirin; Carcinogens; Curcumin; Dermatitis; Ear, External; Edema; Female; Ketones; Mice; Mice, Inbred Strains; Platelet Aggregation Inhibitors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Comparison of venous and arterial blood sampling for the assessment of platelet aggregation with whole blood impedance aggregometry.
Topics: Adenosine Diphosphate; Arachidonic Acid; Area Under Curve; Arteries; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Electric Impedance; Female; Humans; Male; Phlebotomy; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Research Design; Specimen Handling; Ticlopidine; Veins | 2011 |
Platelet aggregation is dependent on platelet count in patients with coronary artery disease.
Topics: Adult; Aged; Arachidonic Acid; Aspirin; Case-Control Studies; Chi-Square Distribution; Collagen; Coronary Angiography; Coronary Artery Disease; Denmark; Erythrocyte Count; Female; Hematocrit; Humans; Leukocyte Count; Linear Models; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Predictive Value of Tests; Time Factors; Treatment Outcome; Young Adult | 2012 |
Twice daily aspirin to improve biological aspirin efficacy in patients with essential thrombocythemia.
Topics: Aged; Arachidonic Acid; Aspirin; Drug Administration Schedule; Drug Resistance; Female; Humans; Male; Middle Aged; Paris; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Thrombocythemia, Essential; Time Factors; Treatment Outcome | 2012 |
Platelet reactivity in type 2 diabetes mellitus: a comparative analysis with survivors of myocardial infarction and the role of glycaemic control.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Glucose; Blood Platelets; Collagen; Diabetes Mellitus, Type 2; Epinephrine; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Severity of Illness Index; Survivors | 2012 |
[Aspirin response and related factors in aged patients].
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Coronary Artery Disease; Gastrointestinal Hemorrhage; Humans; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2011 |
Persistent high on-treatment platelet reactivity in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Arachidonic Acid; Aspirin; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Treatment Outcome | 2012 |
Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis.
Topics: Acetaminophen; Androgen Antagonists; Animals; Arachidonic Acid; Aspirin; Cryptorchidism; Endocrine Disruptors; Female; Indomethacin; Male; Pregnancy; Prostaglandin D2; Rats; Testis; Testosterone | 2012 |
Irbesartan does not influence the antiplatelet effect of aspirin in spontaneously hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arachidonic Acid; Aspirin; Biphenyl Compounds; Collagen; Drug Interactions; Irbesartan; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred SHR; Tetrazoles | 2012 |
Effect of different anticoagulants on multiple electrode platelet aggregometry after clopidogrel and aspirin administration in patients undergoing coronary stent implantation: a comparison between citrate and hirudin.
Topics: Adenosine Diphosphate; Aged; Analysis of Variance; Angioplasty, Balloon, Coronary; Anticoagulants; Arachidonic Acid; Aspirin; Citric Acid; Clopidogrel; Female; Hirudins; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; ROC Curve; Sensitivity and Specificity; Stents; Ticlopidine | 2013 |
Metabolomic investigation of the anti-platelet aggregation activity of ginsenoside Rk₁ reveals attenuated 12-HETE production.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ginsenosides; Male; Membrane Proteins; Metabolome; Metabolomics; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Principal Component Analysis; Protein Transport; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 2012 |
EV-077 in vitro inhibits platelet aggregation in type-2 diabetics on aspirin.
Topics: Aged; Aged, 80 and over; Anticoagulants; Arachidonic Acid; Aspirin; Coronary Artery Disease; Diabetes Mellitus, Type 2; Dinoprostone; Female; Hirudins; Humans; Isoprostanes; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Umbilical Arteries; Vascular Resistance | 2012 |
In vitro platelet antiaggregatory properties of 4-methylcoumarins.
Topics: Adenosine Diphosphate; Anticoagulants; Arachidonic Acid; Aspirin; Collagen; Coumarins; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Humans; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane-A Synthase; Umbelliferones | 2012 |
Clinical and biochemical aspirin resistance in patients with recurrent cerebral ischemia.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Brain Ischemia; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Specimen Handling; Treatment Failure | 2013 |
Postmenopausal women have an increased maximal platelet reactivity compared to men despite dual antiplatelet therapy.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Coronary Disease; Female; Humans; Male; Middle Aged; Peptide Fragments; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Postmenopause; Prospective Studies; Sex Factors; Ticlopidine | 2012 |
LC-MS/MS for the simultaneous analysis of arachidonic acid and 32 related metabolites in human plasma: Basal plasma concentrations and aspirin-induced changes of eicosanoids.
Topics: Arachidonic Acid; Aspirin; Chromatography, Liquid; Drug Stability; Humans; Male; Metabolome; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2012 |
Assessment of high on-treatment platelet reactivity in patients with ischemic heart disease: concordance between the Multiplate and VerifyNow assays.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Reproducibility of Results; Spain; Ticlopidine; Treatment Outcome | 2013 |
Aspirin treatment hampers the use of plasma microRNA-126 as a biomarker for the progression of vascular disease.
Topics: Analysis of Variance; Arachidonic Acid; Aspirin; Biomarkers; Contraindications; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Progression; Female; Humans; Male; MicroRNAs; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; von Willebrand Factor | 2013 |
High-dose aspirin in dogs increases vascular resistance with limited additional anti-platelet effect when combined with potent P2Y12 inhibition.
Topics: Adenosine; Animals; Arachidonic Acid; Aspirin; Clopidogrel; Dogs; Dose-Response Relationship, Drug; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombosis; Ticagrelor; Ticlopidine; Vascular Resistance | 2013 |
A mechanistic hypothesis for the aspirin-induced switch in lipid mediator production by cyclooxygenase-2.
Topics: Animals; Arachidonic Acid; Aspirin; Biocatalysis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Mice; Models, Molecular; Molecular Structure; Oxygen; Quantum Theory; Stereoisomerism; Structure-Activity Relationship | 2013 |
Initial experiences with Multiplate® for rapid assessment of antiplatelet agent activity in neurosurgical emergencies.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Clopidogrel; Embolization, Therapeutic; Emergencies; Emergency Medical Services; Female; Hemostatic Techniques; Humans; Intracranial Hemorrhages; Male; Middle Aged; Neurosurgical Procedures; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Transfusion; Point-of-Care Systems; Ticlopidine | 2013 |
The influence of aspirin on release of eoxin C4, leukotriene C4 and 15-HETE, in eosinophilic granulocytes isolated from patients with asthma.
Topics: Adult; Arachidonate 15-Lipoxygenase; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Aspirin; Asthma, Aspirin-Induced; Eosinophils; Female; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene C4; Leukotrienes; Male; Middle Aged; Young Adult | 2013 |
Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.
Topics: Acetylation; Amino Acid Sequence; Amino Acid Substitution; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Flurbiprofen; Guanidine; Heme; Humans; Indomethacin; Kinetics; Models, Biological; Mutant Proteins; Mutation; Naproxen; Oxygen; Palmitic Acid; Peroxidase; Protein Multimerization; Pyrazoles; Substrate Specificity; Sulfonamides | 2013 |
Antiplatelet loading improves behavioral outcome in a rabbit model of stroke.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Brain Ischemia; Collagen; Disease Models, Animal; Embolization, Therapeutic; Fibrinolytic Agents; Male; Platelet Aggregation Inhibitors; Rabbits; Random Allocation; Treatment Outcome | 2013 |
Ratio of eicosapentaenoic acid to arachidonic acid is a critical risk factor for acute coronary syndrome in middle-aged older patients as well as younger adult patients.
Topics: Acute Coronary Syndrome; Adult; Aged; Angiotensin Receptor Antagonists; Arachidonic Acid; Aspirin; Calcium Channel Blockers; Cholesterol, HDL; Coronary Angiography; Drugs, Chinese Herbal; Eicosapentaenoic Acid; Eleutherococcus; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Multivariate Analysis; Risk Factors; Smoking | 2014 |
The effects of an inhibitor of diglyceride lipase on collagen-induced platelet activation.
Topics: Arachidonic Acid; Aspirin; Blotting, Western; Collagen; Enzyme Inhibitors; Humans; Isoleucine; Lactones; Lipoprotein Lipase; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activation; Platelet Aggregation; Thromboxanes | 2013 |
Effects of ex vivo platelet supplementation on platelet aggregability in blood samples from patients treated with acetylsalicylic acid, clopidogrel, or ticagrelor.
Topics: Adenosine; Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Transfusion; Ticagrelor; Ticlopidine | 2014 |
Changes in response to antiaggregatory treatment in patients with myeloproliferative neoplasms: a sequential study using multiple electrode aggregometry.
Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Case-Control Studies; Clopidogrel; Electrodes; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Myeloproliferative Disorders; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Thrombosis; Ticlopidine; Treatment Outcome | 2013 |
Mechanisms of aspirin-intolerant asthma: identifying inflammatory pathways in the pathogenesis of asthma.
Topics: Arachidonate 15-Lipoxygenase; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Aspirin; Asthma, Aspirin-Induced; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Cysteine; Eosinophils; Humans; Leukotrienes | 2014 |
Response to antiplatelet therapy and platelet reactivity to thrombin receptor activating peptide-6 in cardiovascular interventions: Differences between peripheral and coronary angioplasty.
Topics: Adenosine Diphosphate; Aged; Angioplasty; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Monocytes; P-Selectin; Peptide Fragments; Percutaneous Coronary Intervention; Peripheral Arterial Disease; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prognosis; Stents; Ticlopidine | 2014 |
Alditols and monosaccharides from sorghum vinegar can attenuate platelet aggregation by inhibiting cyclooxygenase-1 and thromboxane-A2 synthase.
Topics: Acetic Acid; Adult; Arachidonic Acid; Aspirin; Cyclooxygenase 1; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; In Vitro Techniques; Molecular Docking Simulation; Monosaccharides; Plant Extracts; Platelet Aggregation Inhibitors; Sorghum; Sugar Alcohols; Thromboxane A2; Thromboxane-A Synthase; Young Adult | 2014 |
Increased platelet expression of glycoprotein IIIa following aspirin treatment in aspirin-resistant but not aspirin-sensitive subjects.
Topics: Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cohort Studies; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Resistance; Female; Healthy Volunteers; Humans; Integrin beta3; Male; Platelet Aggregation; Thromboxane B2 | 2014 |
Assessment of platelet function with light transmission aggregometry in 24 patients supported with a continuous-flow left ventricular assist device: a single-center experience.
Topics: Aged; Arachidonic Acid; Aspirin; Drug Administration Schedule; Drug Monitoring; Female; France; Heart Failure; Heart-Assist Devices; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Prosthesis Design; Risk Factors; Ristocetin; Thromboembolism; Time Factors; Treatment Outcome; Ventricular Function, Left | 2014 |
Precision and reliability of 5 platelet function tests in healthy volunteers and donors on daily antiplatelet agent therapy.
Topics: Arachidonic Acid; Aspirin; Clopidogrel; Female; Healthy Volunteers; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reproducibility of Results; Sensitivity and Specificity; Ticlopidine | 2014 |
The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Aspirin; Atherosclerosis; Bile Acids and Salts; Cells, Cultured; Cholesterol; Cholesterol, HDL; Humans; Leukotrienes; Liver; Metabolome; Mice; Mice, Inbred C57BL | 2014 |
[The effect of cyclooxygenase and lipoxygenase inhibitors on Ca(2+)-responses induced by glutoxim and molixan in macrophages].
Topics: Animals; Arachidonic Acid; Aspirin; Caffeic Acids; Calcium; Calcium Signaling; Cyclooxygenase Inhibitors; Flavanones; Hematinics; Indomethacin; Lipoxygenase Inhibitors; Macrophages, Peritoneal; Masoprocol; Oligopeptides; Primary Cell Culture; Rats; Rats, Wistar | 2014 |
Arachidonic acid-stimulated platelet tests: Identification of patients less sensitive to aspirin treatment.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Platelets; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Retrospective Studies; Thromboxane B2 | 2015 |
Comparison of aspirin and indobufen in healthy volunteers.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Cross-Over Studies; Drug Administration Schedule; Female; Healthy Volunteers; Humans; Isoindoles; Male; Middle Aged; Phenylbutyrates; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 2016 |
Comparison between urinary 11-dehydrothromboxane B2 detection and platelet Light Transmission Aggregometry (LTA) assays for evaluating aspirin response in elderly patients with coronary artery disease.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Platelets; Coronary Artery Disease; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane B2; Treatment Outcome | 2015 |
The effectiveness of platelet supplementation for the reversal of ticagrelor-induced inhibition of platelet aggregation: An in-vitro study.
Topics: Adenosine; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Transfusion; Ticagrelor | 2016 |
Low platelet activity predicts 30 days mortality in patients undergoing heart surgery.
Topics: Adenosine Diphosphate; Aged; Aortic Valve; Arachidonic Acid; Area Under Curve; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Erythrocyte Transfusion; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Retrospective Studies; Risk Factors; Survival Analysis; Thrombosis; Ticlopidine; Treatment Outcome | 2016 |
Acetylsalicylic acid resistance risk factors in patients with myocardial infarction.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; C-Reactive Protein; Drug Resistance; Female; Humans; Leukocyte Count; Male; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Platelet Aggregation; Platelet Aggregation Inhibitors; Prevalence; Prospective Studies; Risk Factors | 2015 |
Platelet function recovery following exposure to triple anti-platelet inhibitors using an in vitro transfusion model.
Topics: Apoptosis Regulatory Proteins; Arachidonic Acid; Aspirin; Blood Platelets; Blood Transfusion; Clopidogrel; Flow Cytometry; Hemorrhage; Humans; Lactones; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Transfusion; Purinergic P2Y Receptor Antagonists; Pyridines; Receptors, Proteinase-Activated; Receptors, Purinergic P2Y12; Ticlopidine | 2015 |
Relationship between high on aspirin platelet reactivity and oxidative stress in coronary artery by-pass grafted patients.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Coronary Artery Bypass; Coronary Artery Disease; Coronary Vessels; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Oxidative Stress; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2016 |
Antiplatelet effects of aspirin in chronic kidney disease patients.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Platelets; Cardiovascular Diseases; Cross-Sectional Studies; Drug Resistance; Female; Glomerular Filtration Rate; Humans; Kidney; Linear Models; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Renal Insufficiency, Chronic; Risk Factors; Severity of Illness Index; Thromboxanes | 2016 |
The lack of aspirin resistance in patients with coronary artery disease.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Coronary Artery Disease; Cyclooxygenase 1; Cyclooxygenase 2; Drug Resistance; Female; Gene Expression Regulation, Enzymologic; Humans; Male; Middle Aged; Platelet Aggregation; RNA, Messenger; Thromboxane B2 | 2016 |
Multiple Electrode Aggregometry is an adequate method for aspirin response testing in myeloproliferative neoplasms and differentiates the mechanisms of aspirin resistance.
Topics: Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Platelets; Drug Resistance; Electrodes; Female; Humans; Male; Middle Aged; Myeloproliferative Disorders; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Thromboxane B2; Young Adult | 2016 |
A novel thromboxane receptor antagonist, nstpbp5185, inhibits platelet aggregation and thrombus formation in animal models.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Aspirin; Benzimidazoles; Blood Platelets; Calcium; Collagen; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Microvessels; P-Selectin; Platelet Aggregation; Pulmonary Embolism; Receptors, Thromboxane A2, Prostaglandin H2; Thrombosis; Thromboxane A2 | 2016 |
Dipyrone comedication in aspirin treated stroke patients impairs outcome.
Topics: Aged; Aged, 80 and over; Analgesics; Arachidonic Acid; Aspirin; Cohort Studies; Dipyrone; Drug Interactions; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Stroke | 2016 |
[Dose-response of aspirin on platelet function in very elderly patients].
Topics: Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Female; Gastrointestinal Hemorrhage; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests | 2016 |
Platelet dysfunction in critically ill patients.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelet Disorders; Critical Illness; Female; Humans; Male; Middle Aged; Platelet Function Tests; Retrospective Studies; Thrombelastography | 2017 |
Pseudomonas aeruginosa produces aspirin insensitive eicosanoids and contributes to the eicosanoid profile of polymicrobial biofilms with Candida albicans.
Topics: Arachidonic Acid; Aspirin; Biofilms; Candida albicans; Chromatography, Liquid; Dinoprostone; Eicosanoids; Masoprocol; Pseudomonas aeruginosa; Tandem Mass Spectrometry | 2017 |
Platelet reactivity in thromboelastometry. Revision of the FIBTEM test: a basic study.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Coagulation Tests; Blood Platelets; Collagen; Cytochalasin D; Female; Fibrin; Fibrinogen; Humans; Integrin beta3; Male; Oligopeptides; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoprotein IIb; Primary Cell Culture; Thrombelastography | 2017 |
Synthesis, antiplatelet and antithrombotic activities of resveratrol derivatives with NO-donor properties.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Bleeding Time; Collagen; Fibrinolytic Agents; Hydrazones; Isosorbide Dinitrate; Male; Mice; Nitric Oxide Donors; Nitrites; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats, Wistar | 2017 |
Topics: Animals; Aorta; Arachidonic Acid; Aspirin; Cell Adhesion Molecules; DNA, Bacterial; Endothelial Cells; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Hydroxyurea; Inflammation; Intercellular Adhesion Molecule-1; Male; Mice; Mice, Inbred BALB C; Monocytes; Mutation; Phospholipases A2; Recombinant Proteins; Signal Transduction; Streptococcus pyogenes; THP-1 Cells; Vascular Cell Adhesion Molecule-1 | 2017 |
Lack of Bioequivalence Among Low-dose, Enteric-coated Aspirin Preparations.
Topics: Arachidonic Acid; Aspirin; Dose-Response Relationship, Drug; Humans; Peptide Fragments; Platelet Aggregation Inhibitors; Tablets, Enteric-Coated; Therapeutic Equivalency; Thromboxane A2 | 2018 |
Physiopathology and genetics in aspirin-exacerbated respiratory disease.
Topics: Antigen Presentation; Arachidonic Acid; Aspirin; Asthma, Aspirin-Induced; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Inflammation; Polymorphism, Single Nucleotide | 2017 |
On-treatment platelet reactivity in peripheral and coronary blood in patients undergoing primary PCI for ST-segment elevation myocardial infarction (STEMI).
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Coronary Vessels; Demography; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; ST Elevation Myocardial Infarction | 2018 |
Multifaceted effects of arachidonic acid and interaction with cyclic nucleotides in human platelets.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Cell Survival; Cyclic AMP; Cyclic GMP; Drug Resistance; Humans; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Protein Kinases | 2018 |
Dose reduction, oral application, and order of intake to preserve aspirin antiplatelet effects in dipyrone co-medicated chronic artery disease patients.
Topics: Administration, Oral; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Coronary Artery Disease; Dipyrone; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors | 2019 |
Variations in the eicosapentaenoic acid-arachidonic acid ratio associated with age in acute myocardial infarction patients undergoing primary percutaneous coronary intervention.
Topics: Age Factors; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Biomarkers; Eicosapentaenoic Acid; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Retrospective Studies; Risk Factors; ROC Curve | 2019 |
Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex.
Topics: Animals; Arachidonic Acid; Arginine; Aspirin; Celecoxib; Crystallography, X-Ray; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Enzyme Assays; Histidine; Hydroxyeicosatetraenoic Acids; Leucine; Mutagenesis, Site-Directed; Recombinant Proteins; Sf9 Cells; Stereoisomerism; Substrate Specificity; Time Factors | 2019 |
Residual platelet reactivity is preferred over platelet inhibition rate in monitoring antiplatelet efficacy: insights using thrombelastography.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Thrombelastography | 2020 |
Poor control of asthma symptoms with interleukin-5 inhibitors in four patients with aspirin-exacerbated respiratory disease.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Arachidonic Acid; Aspirin; Asthma, Aspirin-Induced; Female; Humans; Interleukin-5; Leukotrienes; Male; Middle Aged | 2020 |
Estimating short- and long-term reference change values and index of individuality for tests of platelet function.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Biological Variation, Population; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Normal Distribution; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reference Values; Thrombosis | 2019 |
Determinants of aspirin resistance in patients with type 2 diabetes.
Topics: Aged; Arachidonic Acid; Aspirin; C-Reactive Protein; Coronary Artery Disease; Diabetes Mellitus, Type 2; Drug Resistance; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Insulin Resistance; Interleukin-10; Interleukin-6; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Severity of Illness Index; Thrombopoietin; Thromboxane B2; Tumor Necrosis Factor-alpha; Vascular Calcification | 2020 |
Differential expression of microRNA and arachidonic acid metabolism in aspirin-treated human cardiac and peri-cardiac fat-derived mesenchymal stem cells.
Topics: Adipose Tissue; Anticoagulants; Arachidonic Acid; Aspirin; Cells, Cultured; Cyclooxygenase Inhibitors; Humans; Mesenchymal Stem Cells; MicroRNAs; Myocardium; Phenotype; Transcriptome | 2020 |
Ticagrelor and prasugrel are independent predictors of improved long-term survival in ACS patients.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Cardiovascular Diseases; Clopidogrel; Dual Anti-Platelet Therapy; Female; Humans; Male; Middle Aged; Mortality; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prognosis; Proportional Hazards Models; Prospective Studies; Secondary Prevention; Stroke; Survival Rate; Ticagrelor | 2020 |
Characterization of cyclooxygenase-2 acetylation and prostanoid inhibition by aspirin in cellular systems.
Topics: Acetylation; Amino Acid Sequence; Arachidonic Acid; Aspirin; Cell Line, Tumor; Chromatography, Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Epithelial Cells; Gene Expression; Humans; Hydroxyeicosatetraenoic Acids; Interleukin-1beta; Lipopolysaccharides; Mass Spectrometry; Monocytes; Primary Cell Culture; Protein Processing, Post-Translational; Recombinant Proteins; Serine | 2020 |
Lower Platelet Aggregation Is a Risk Factor for Dual Antiplatelet Therapy-Associated Bleeding: A Preliminary Retrospective Study with Genotype Analysis.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Case-Control Studies; Dual Anti-Platelet Therapy; Female; Genotype; Glutathione S-Transferase pi; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Polymorphism, Single Nucleotide; Receptors, Cell Surface; Retrospective Studies; Ticagrelor | 2020 |
Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin.
Topics: Animals; Arachidonic Acid; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Eicosanoids; Female; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Thrombosis | 2020 |
Synergistic platelet inhibition between Omega-3 and acetylsalicylic acid dose titration; an observational study.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Drug Synergism; Drug Therapy, Combination; Fatty Acids, Omega-3; Humans; Male; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Young Adult | 2020 |
Short-Term Cessation of Dabigatran Causes a Paradoxical Prothrombotic State.
Topics: Aged; Aged, 80 and over; Animals; Antithrombins; Arachidonic Acid; Aspirin; Carotid Artery Thrombosis; Cerebral Infarction; Chlorides; Computed Tomography Angiography; Dabigatran; Deprescriptions; Factor Xa Inhibitors; Female; Ferric Compounds; Humans; Ischemic Stroke; Magnetic Resonance Angiography; Male; Mean Platelet Volume; Mice; Noxae; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Pyrazoles; Pyridones; Rivaroxaban; Severity of Illness Index; Substance Withdrawal Syndrome; Thrombin; Thrombophilia; X-Ray Microtomography | 2021 |
Arachidonic acid-induced platelet aggregation and acetylsalicylic acid treatment during pregnancy in women with recurrent miscarriage, a post hoc study.
Topics: Abortion, Habitual; Adult; Arachidonic Acid; Aspirin; Case-Control Studies; Female; Humans; Platelet Aggregation; Pregnancy | 2022 |
Stronger inhibitory effects of Ticagrelor plus aspirin compared with Clopidogrel plus aspirin on arachidonic acid-induced platelet aggregation in patients with acute coronary syndrome with PCI.
Topics: Acute Coronary Syndrome; Adenosine; Arachidonic Acid; Aspirin; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2021 |
The Synergistic Effect of
Topics: Animals; Arachidonic Acid; Aspirin; Chromatography, High Pressure Liquid; Cyclic AMP; Drug Synergism; Ginkgo biloba; Male; Mass Spectrometry; Plant Extracts; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, G-Protein-Coupled; Thromboxane B2 | 2021 |
Comparative study on the effect of aspirin, TP receptor antagonist and TxA
Topics: Arachidonic Acid; Aspirin; Benzofurans; Carbazoles; Enzyme Inhibitors; Female; Humans; Male; Mammary Arteries; Muscle, Smooth, Vascular; Phenylephrine; Receptors, Prostaglandin; Receptors, Thromboxane; Saphenous Vein; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes; Vasoconstriction | 2021 |
Thromboelastography with platelet mapping: Limited predictive ability in detecting preinjury antiplatelet agent use.
Topics: Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Platelets; Domperidone; Female; Hemorrhage; Humans; Male; Medication Reconciliation; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; ROC Curve; Thrombelastography; Wounds and Injuries | 2021 |
Whole-Body PET Imaging in Humans Shows That
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Ketoprofen; Positron-Emission Tomography | 2023 |
Aspirin Administration Mitigates Platelet Hyperaggregability After Splenectomy in a Murine Model.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Disease Models, Animal; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Splenectomy | 2022 |
Serial assessment of thrombogenicity and hemodynamics in patients with type II diabetes in a clinical research unit: Evidence for circadian variations in clot formation.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Pressure; Circadian Rhythm; Diabetes Mellitus, Type 2; Humans; Thrombosis | 2022 |
Utility of constraints reflecting system stability on analyses for biological models.
Topics: Algorithms; Anti-Inflammatory Agents; Arachidonic Acid; Aspirin; Models, Biological; NF-kappa B; Prostaglandins I; Thromboxane A2 | 2022 |
Targeting the Leukotriene Pathway for Colon Cancer Interception.
Topics: Aberrant Crypt Foci; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Aspirin; Chemoprevention; Colon; Colonic Neoplasms; Humans; Inflammation; Leukotriene Antagonists; Leukotrienes; Prostaglandin-Endoperoxide Synthases | 2022 |
Platelet function testing using the Multiplate analyzer after administration of aspirin in Aachen minipigs.
Topics: Adenosine; Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Diphosphates; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Thrombin; Swine; Swine, Miniature | 2022 |
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
Topics: Arachidonic Acid; Aspirin; Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; DNA-Binding Proteins; Humans; Liver Neoplasms; Phosphopyruvate Hydratase; Tumor Suppressor Proteins | 2023 |
Effect of ticagrelor and clopidogrel dual antiplatelet therapy on MPVLR, MAADP, and AA inhibition rate in acute coronary syndrome patients after percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Arachidonic Acid; Aspirin; Clopidogrel; Gelsolin; Humans; Mean Platelet Volume; MicroRNAs; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Stroke Volume; Ticagrelor; Ventricular Function, Left | 2023 |