aspirin has been researched along with alprostadil in 129 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 64 (49.61) | 18.7374 |
| 1990's | 33 (25.58) | 18.2507 |
| 2000's | 15 (11.63) | 29.6817 |
| 2010's | 14 (10.85) | 24.3611 |
| 2020's | 3 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Bicking, JB; Cragoe, EJ; Holtz, WJ; Jones, JH; Kuehl, FA; Minsker, DH; Robb, CH | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Waitzman, MB | 1 |
| Bayley, D; Cooper, RG; Freemont, AJ; Hayes, ME; Mawer, EB; Rai, A | 1 |
| Abramson, SB; Kitsis, EA; Weissmann, G | 1 |
| Kambayashi, J; Kawasaki, T; Mori, T; Sakon, M; Shiba, E; Tahara, H; Yokota, M | 1 |
| Geissler, C; Gruss, JD; Hiemer, W; Kroiss, A | 1 |
| Morgenstern, E; Patscheke, H; Ruf, A | 1 |
| Broen, JJ; Cafruny, WA; DesJarlais, SE; Hecht, ML; Jaqua, RA | 1 |
| Bergmann, JF; Caulin, C; Naudin, R; Segrestaa, JM; Simoneau, G | 1 |
| Albrecht, M; Brandt, KD; O'Bryan-Tear, G | 1 |
| Schubert, ML | 1 |
| Rao, GH; White, JG | 1 |
| Deby, C; Moiny, G; Thirion, A | 1 |
| Frauchiger, B | 1 |
| Blueml, G; Dajani, EZ; Lewin, J; Reimann, HJ; Schmidt, U; Wendt, P | 1 |
| Jiranek, GC; Kimmey, MB; Saunders, DR; Shanahan, W; Silverstein, FE; Willson, RA | 1 |
| Agrawal, N; Crager, M; Mahowald, M; Miller, S; Montoya, H; Nissen, C; Nutting, E; Robbins, D; Roth, S; Woods, E | 1 |
| Just, M; Schlotte, V; Seiffge, D; Weithmann, KU | 1 |
| Beythien, C; Bleifeld, W; Kupper, W; Terres, W | 1 |
| Chesney, CM; Leffler, C; Mirro, R; Sibai, BM | 1 |
| Alino, SF; Garcia, D; Uvnäs-Moberg, K | 1 |
| Almawi, WY; Pope, BL | 1 |
| Pillay, DJ; Pope, BL | 1 |
| Karmazyn, M; Pillay, DJ; Pope, BL | 1 |
| Botha, JH; Leary, WP; Robinson, KM | 1 |
| Cordasco, DM; Rotrosen, J; Segarnick, DJ | 1 |
| Forn, J; García-Rafanell, J; Gomez, L; Ramis, J | 1 |
| Kimmey, MB; Levine, DS; Saunders, DR; Silverstein, FE | 1 |
| Bauer, RF; Bianchi, RG; Casler, J; Goldstin, B | 1 |
| Dammann, HG; Müller, P; Simon, B | 2 |
| Kimmey, MB; Saunders, DR; Silverman, BA; Silverstein, FE; Surawicz, CM; Willson, RA | 1 |
| Clay, GA; McMahon, FG; Ryan, JR; Vargas, R | 1 |
| Anglin, CP; Bauer, RF; Dajani, EZ; Gullikson, GW; Kessler, LK; Smeach, S | 1 |
| Hu, SJ; Jen, CJ | 1 |
| Laudanno, OM | 1 |
| Dickson, B; Gustitus, L; Lanza, F; Peace, K; Rack, MF | 1 |
| Gana, TJ; Koo, J; MacPherson, BR | 1 |
| Albors, M; De Castellarnau, C; Rutllant, ML; Sancho, MJ; Vila, L | 1 |
| Badian, MJ; Frölich, JC; Rupp, WA; Zapf, RM | 1 |
| Schaible, HG; Schmidt, RF | 1 |
| Barr, RD; Buchanan, MR; Gibson, BE; White, JG | 1 |
| Dveksler, G; Franchi, AM; Gimeno, AL; Gimeno, MF; Viggiano, M | 1 |
| Golombek, M; Goppelt-Strübe, M; Resch, K; Röbbecke, K | 1 |
| Fujitani, B; Kadokawa, T; Kitagawa, T; Kuwashima, J; Tsuboi, T; Watanabe, M | 1 |
| McLennan, IS | 2 |
| Goldman, CD; Rudloff, MA; Ternberg, JL | 1 |
| Merris, CS; Solen, KA | 1 |
| Santoro, SA | 1 |
| Herman, CA; Herman, RP | 1 |
| Fernandez-Pardal, J; Gimeno, AL; Gimeno, MF | 1 |
| Pilger, E | 1 |
| Burghoffer, B; Daguet, GL; Petit, JC; Richard, G | 1 |
| Dajani, EZ; Nissen, CH | 1 |
| Nydegger, UE; Spycher, MO | 1 |
| Aristoff, PA; Gorman, RR; Kimball, FA; Miller, WL; Robert, A; Wendling, MG | 1 |
| Adams, GA; Feuerstein, IA | 1 |
| Hausman, RE; Velleman, SG | 1 |
| Hood, B; Israelsson, B; Mattiasson, I; Stavenow, L | 1 |
| Biland, L; Bollinger, A; Brunner, U; Kappert, A; Krähenbühl, B; Mahler, F; Monti, M; Nachbur, B; Schneider, E; Widmer, LK | 1 |
| Conolly, ME; Fisher, HK; Hui, KK; Tashkin, DP; Wolfe, RN | 1 |
| Kimura, Y; Yasunaga, K | 1 |
| Danneskiold-Samsøe, B; Dore-Duffy, P; Offner, H | 1 |
| Fitscha, P; Kaliman, J; O'Grady, J; Sinzinger, H | 1 |
| Capdepon, E; Finkelstein, D; Laudanno, OM | 1 |
| Hunt, JN; Jiang, CL; Kessler, L; Smith, JL | 1 |
| Das, UN | 1 |
| Bertelé, V; Cerletti, C; de Gaetano, G; Di Minno, G; Silver, MJ | 1 |
| Bass, P; Gullikson, GW; Sender, M | 1 |
| Cardinali, DP; Pereyra, E; Rita, MN; Solveyra, CG | 1 |
| Margolis, M; Mohan, KK | 1 |
| Smith, JB | 1 |
| Cassidy, MM; Lightfoot, FG; Vahouny, GV | 1 |
| Kuenzig, M; Thörne, LJ; Thörnee, LJ | 1 |
| Aubert, D; Ferrand, C; Loubrie, JC; Tuong, A; Tuong, CC | 1 |
| Casolaro, V; de Paulis, A; Guidi, G; Marino, O; Marone, G; Meliota, S; Patella, V | 1 |
| Gear, AR; Polanowska-Grabowska, R | 1 |
| Bauman, WA; Kahn, NN; Sinha, AK | 1 |
| Garrett, KO; Johnson, PC; Pautler, SV | 1 |
| Li, SR; Pirker, W; Virgolini, I; Wandl, E; Yang, Q | 1 |
| Kawashima, A; Koike, H; Nishio, S; Ueno, Y | 1 |
| Comunale, ME; Johnson, RG; Shorten, G | 1 |
| Li, ZY; Lian, EC; Yu, TF | 1 |
| Rogatti, W; Sinzinger, H | 1 |
| Iyengar, B; Kotwani, A; Mehta, VL | 1 |
| Amico, MC; Morrone, LA; Romanelli, L; Valeri, P | 1 |
| Kambayashi, J; Sakon, M | 1 |
| Alemany, M; Bastida, E; Bozzo, J; Buchanan, MR; Hernández, R; Ordinas, A | 1 |
| Cmiel, A; Mastalerz, L; Nizankowska, E; Szczeklik, A | 1 |
| Fukushi, H; Imura, Y; Kawamura, M; Kita, S; Moriya, N; Nishikawa, K; Sugihara, H; Terashita, Z | 1 |
| Annoh, S; Koike, H; Nishio, S; Ueno, Y | 1 |
| Bernasconi, S; Dejana, E; Del Maschio, A; Martín-Padura, I | 1 |
| Guichardant, M; Lagarde, M; Pageaux, JF; Thevenon, C | 1 |
| Belenkov, IuN; Chazova, IE; Lazutkina, VK; Martyniuk, TV; Masenko, VP | 1 |
| Belcher, G; Horrocks, M; Watson, HR | 1 |
| Hafner, J | 1 |
| Butenas, S; Cawthern, KM; DiLorenzo, ME; Lock, JB; Mann, KG; van't Veer, C | 1 |
| Cauwenberghs, N; Cooper, S; Deckmyn, H; Descheemaeker, G; Schlammadinger, A; Tornai, I; Vauterin, S | 1 |
| Alston, SM; Goodman, PD; Hall, MW; Solen, KA | 1 |
| Cho, SJ; Han, SB; Lee, KS; Lee, SJ; Suh, JD; Yoo, JC | 1 |
| Kennedy, JH; Korn, N; Thurston, RJ | 1 |
| Akaike, A; Banno, Y; Fushimi, K; Nakashima, S; Shimizu, K; Takigawa, M | 1 |
| Bhattacharya, G; Girish, GV; Sinha, AK | 1 |
| Beilin, O; Blank, M; Chapman, J; Grigoriadis, NC; Katzav, A; Landenberg, Pv; Pick, CG; Shoenfeld, Y; Tanne, D | 1 |
| Ishikawa, O; Nagai, Y; Okada, E | 1 |
| Eckstein, HH; Grau, C; Stammler, F | 1 |
| Chen, KR; Ishibashi, M; Miyamoto, J; Nagasaka, T | 1 |
| Gouya, G; Jilma, B; Siller-Matula, JM; Wolzt, M | 1 |
| Adachi, A; Fujiwara, N; Fukumoto, T; Inoue, Y; Kohno, K; Matsuo, H; Morita, E; Nishitani, N; Ueno, M | 1 |
| Desta, Z; Flockhart, DA; Jin, Y; Kovacs, R; Kreutz, RP; Kreutz, Y; Miao, J; Nystrom, P | 1 |
| Khachikyan, MV; Khaspekova, SG; Mazurov, AV; Ruda, MY; Yakushkin, VV; Zyuryaev, IT | 1 |
| Baldelli, F; Cipriani, S; D'Amore, C; Distrutti, E; Fiorucci, S; Francisci, D; Mencarelli, A; Renga, B; Santucci, L | 1 |
| Alobid, I; Gabasa, M; Machado-Carvalho, L; Martín, M; Mullol, J; Picado, C; Pujols, L; Roca-Ferrer, J; Torres, R | 1 |
| Alobid, I; Machado-Carvalho, L; Mullol, J; Perez-Gonzalez, M; Picado, C; Pujols, L; Roca-Ferrer, J; Torres, R | 1 |
| Baptista-Silva, JC; Cacione, DG; Macedo, CR | 2 |
| Lee, JH; Park, TK; Shin, SJ | 1 |
| Hernandez-Gonzalez, L; López Juan, MG; Majluf-Cruz, A; Martinez, M; Mayoral-Andrade, G; Perez Campos Mayoral, C; Perez-Campos Mayoral, E; Pérez-Campos, E; Pérez-Campos-Mayoral, L; Pérez-Santiago, AD; Rocha-Núñez, A; Zenteno, E | 1 |
| Baptista-Silva, JC; Cacione, DG; do Carmo Novaes, F; Macedo, CR | 1 |
| Bokemeyer, C; Fiehler, J; Frölich, AM; Haddad, M; Holst, B; Holstein, K; Janjetovic, S; Langer, F; Renné, T; Rolling, CC; Rolling, T; Tomada, J; Voigtländer, M | 1 |
| Alieva, AK; Antonova, OA; Dobrovolsky, AB; Khaspekova, SG; Mazurov, AV; Muravlev, IA; Pevzner, DV | 1 |
8 review(s) available for aspirin and alprostadil
| Article | Year |
|---|---|
Proposed metabolic dysfunctions in diabetic microthromboses and microangiopathy.
Topics: Alprostadil; Aspirin; Blood Platelets; Calcimycin; Collagen; Cyclic AMP; Cyclic GMP; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Dinoprost; Dinoprostone; Humans; Indomethacin; Models, Biological; Platelet Aggregation; Prostaglandins; Prostaglandins E; Prostaglandins F; Thromboxane A2 | 1979 |
Atherosclerosis and prostaglandins.
Topics: Alprostadil; Arteriosclerosis; Aspirin; Blood Vessels; Cell Membrane Permeability; Cell Survival; Cholesterol; Endothelium; Epoprostenol; Humans; Platelet Adhesiveness; Prostaglandins; Prostaglandins E; Thromboxane A2 | 1982 |
[Treatment of multiple organ failure].
Topics: Alprostadil; Animals; Antithrombin III; Aspirin; Blood Component Transfusion; Disease Models, Animal; Disseminated Intravascular Coagulation; Heparin; Heparin, Low-Molecular-Weight; Humans; Multiple Organ Failure | 1993 |
Adjuvant medical therapy in peripheral bypass surgery.
Topics: Alprostadil; Anticoagulants; Aspirin; Chemotherapy, Adjuvant; Clinical Trials as Topic; Dextrans; Double-Blind Method; Femoral Artery; Heparin, Low-Molecular-Weight; Humans; Iloprost; Ischemia; Leg; Platelet Aggregation Inhibitors; Popliteal Artery; Prospective Studies; Randomized Controlled Trials as Topic; Ticlopidine; Vascular Surgical Procedures | 1999 |
Management of arterial leg ulcers and of combined (mixed) venous-arterial leg ulcers.
Topics: Alprostadil; Arterial Occlusive Diseases; Aspirin; Bandages; Electric Stimulation Therapy; Exercise Therapy; Humans; Iloprost; Infections; Leg Ulcer; Pain Management; Risk Factors; Spinal Cord; Vascular Surgical Procedures; Venous Insufficiency; Walking | 1999 |
Pharmacological treatment for Buerger's disease.
Topics: Alprostadil; Amputation, Surgical; Aspirin; Epoprostenol; Humans; Iloprost; Prostaglandins; Randomized Controlled Trials as Topic; Thromboangiitis Obliterans; Ulcer | 2016 |
Pharmacological treatment for Buerger's disease.
Topics: Adult; Alprostadil; Amputation, Surgical; Aspirin; Epoprostenol; Humans; Iloprost; Male; Middle Aged; Prostaglandins; Randomized Controlled Trials as Topic; Thromboangiitis Obliterans; Ulcer | 2016 |
Pharmacological treatment for Buerger's disease.
Topics: Adult; Alprostadil; Amputation, Surgical; Aspirin; Epoprostenol; Folic Acid; Hematinics; Humans; Iloprost; Male; Middle Aged; Pain; Placebos; Platelet Aggregation Inhibitors; Prostaglandins; Randomized Controlled Trials as Topic; Thromboangiitis Obliterans; Ulcer | 2020 |
16 trial(s) available for aspirin and alprostadil
| Article | Year |
|---|---|
[Experiences with adjuvant prostaglandin therapy in vascular surgery interventions].
Topics: Alprostadil; Arteriovenous Shunt, Surgical; Aspirin; Graft Occlusion, Vascular; Heparin; Humans; Ischemia; Leg; Postoperative Complications; Prospective Studies | 1991 |
[Protective effect of misoprostol on the changes of transgastric potential difference induced by aspirin in man].
Topics: Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Double-Blind Method; Female; Gastric Mucosa; Humans; Male; Membrane Potentials; Misoprostol | 1991 |
Treatment of NSAID-induced gastroduodenal ulcers.
Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Aspirin; Humans; Misoprostol; Peptic Ulcer | 1990 |
Misoprostol reduces gastroduodenal injury from one week of aspirin: an endoscopic study.
Topics: Adolescent; Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Gastroscopy; Humans; Male; Misoprostol; Random Allocation; Stomach Ulcer | 1989 |
Misoprostol heals gastroduodenal injury in patients with rheumatoid arthritis receiving aspirin.
Topics: Adult; Aged; Alprostadil; Anti-Ulcer Agents; Arthritis, Rheumatoid; Aspirin; Double-Blind Method; Duodenoscopy; Female; Gastroscopy; Humans; Male; Middle Aged; Misoprostol; Multicenter Studies as Topic; Peptic Ulcer; Random Allocation | 1989 |
Low-dose aspirin in pregnancy.
Topics: Alprostadil; Apgar Score; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Ductus Arteriosus, Patent; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Platelet Aggregation; Pregnancy; Pregnancy Trimester, Third; Prospective Studies; Thromboxane B2 | 1989 |
Gastric protection by misoprostol against 1300 mg of aspirin. An endoscopic study.
Topics: Adolescent; Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Clinical Trials as Topic; Double-Blind Method; Gastric Acid; Gastric Mucosa; Gastroscopy; Humans; Misoprostol | 1986 |
[Acute injury to the gastric mucosa by acetylsalicylic acid. A comparative endoscopic study in man with oral prostaglandin analogs, omeprazole and ranitidine].
Topics: Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Clinical Trials as Topic; Double-Blind Method; Gastric Mucosa; Gastroscopy; Humans; Misoprostol; Omeprazole; Prostaglandins E; Prostaglandins, Synthetic; Random Allocation; Ranitidine; Rioprostil; Stomach Ulcer | 1986 |
Gastric protection by misoprostol against 1,300 mg of aspirin. An endoscopic dose-response study.
Topics: Adolescent; Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Dose-Response Relationship, Drug; Gastric Mucosa; Gastroscopy; Humans; Male; Misoprostol | 1987 |
Role of misoprostol in reducing aspirin-induced gastrointestinal blood loss in arthritic patients.
Topics: Alprostadil; Anti-Ulcer Agents; Aspirin; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Misoprostol; Osteoarthritis | 1987 |
A blinded endoscopic comparative study of misoprostol versus sucralfate and placebo in the prevention of aspirin-induced gastric and duodenal ulceration.
Topics: Alprostadil; Anti-Ulcer Agents; Aspirin; Duodenoscopy; Duodenum; Gastric Mucosa; Gastroscopy; Humans; Intestinal Mucosa; Misoprostol; Peptic Ulcer; Random Allocation; Sucralfate | 1988 |
[Stomach tolerance of nonsteroidal antirheumatic drugs: comparative endoscopic study].
Topics: Adult; Alprostadil; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Gastroscopy; Humans; Indomethacin; Misoprostol; Omeprazole; Prostaglandins E; Ranitidine; Rioprostil; Stomach Ulcer | 1987 |
Gastrointestinal cytoprotective effects of misoprostol. Clinical efficacy overview.
Topics: Adult; Alprostadil; Anti-Ulcer Agents; Aspirin; Bile Acids and Salts; DNA; Drug Evaluation; Duodenum; Ethanol; Feces; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Intestinal Mucosa; Male; Membrane Potentials; Misoprostol | 1985 |
[Prostaglandin E1 (misoprostol) and S-adenosylmethionine in the prevention of hemorrhagic gastritis induced by aspirin in the human. Endoscopic, histologic and histochemical study].
Topics: Adult; Alprostadil; Aspirin; Clinical Trials as Topic; Double-Blind Method; Duodenum; Female; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Prostaglandins E; S-Adenosylmethionine; Stomach | 1984 |
Protective and bronchodilator effects of prostaglandin E and salbutamol in aspirin-induced asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Albuterol; Alprostadil; Aspirin; Asthma; Bronchi; Bronchodilator Agents; Dinoprostone; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Misoprostol; Prostaglandins E | 1996 |
Cross validation of the Multiple Electrode Aggregometry. A prospective trial in healthy volunteers.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Arachidonic Acid; Aspirin; Clopidogrel; Electrodes; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine; Time Factors; Young Adult | 2009 |
105 other study(ies) available for aspirin and alprostadil
| Article | Year |
|---|---|
11,12-Secoprostaglandins. 5. 8-Acetyl- or 8-(1-hydroxyethyl)-12-hydroxy-13-aryloxytridecanoic acids and sulfonamide isosteres as inhibitors of platelet aggregation.
Topics: Animals; Cyclic AMP; Decanoic Acids; Female; Guinea Pigs; In Vitro Techniques; Male; Mice; Ovary; Platelet Aggregation; Prostaglandins E; Prostaglandins, Synthetic; Structure-Activity Relationship; Sulfonamides | 1978 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Inhibition by prostaglandin E1 and E2 of 1,25-dihydroxyvitamin D3 synthesis by synovial fluid macrophages from arthritic joints.
Topics: Alprostadil; Arthritis; Aspirin; Calcitriol; Chromatography, High Pressure Liquid; Dinoprostone; Dose-Response Relationship, Drug; Humans; Knee Joint; Macrophages; Synovial Fluid | 1992 |
The prostaglandin paradox: additive inhibition of neutrophil function by aspirin-like drugs and the prostaglandin E1 analog misoprostol.
Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcimycin; Calcium; Cell Aggregation; Cyclic AMP; Depression, Chemical; Drug Synergism; Glucuronidase; Humans; Indomethacin; Misoprostol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Prostaglandins; Sodium Salicylate; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
The possible involvement of platelet activation in endotoxin-induced renal insufficiency in a rabbit model.
Topics: Acetylglucosaminidase; Acute Kidney Injury; Alprostadil; Animals; Aspirin; Endotoxins; Glomerular Filtration Rate; Heparin; Heparin, Low-Molecular-Weight; Kidney; Male; Platelet Activation; Rabbits; Renal Circulation | 1991 |
Role of internalization in platelet activation induced by collagen fibers--differential effects of aspirin, cytochalasin D, and prostaglandin E1.
Topics: Alprostadil; Aspirin; Biometry; Collagen; Cytochalasin D; Humans; Image Processing, Computer-Assisted; Microscopy, Electron; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Serotonin; Thromboxane A2 | 1991 |
Enhancement of murine susceptibility to oral lactate dehydrogenase-elevating virus infection by non-steroidal anti-inflammatory agents, and antagonism by misoprostol.
Topics: Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Aspirin; Diclofenac; Female; Indomethacin; Lactate dehydrogenase-elevating virus; Mice; Mice, Inbred Strains; Misoprostol; Virus Diseases | 1991 |
Misoprostol does not protect articular cartilage from salicylate-induced suppression of proteoglycan synthesis.
Topics: Alprostadil; Animals; Aspirin; Cartilage, Articular; Cells, Cultured; Culture Media; Dogs; Glycosaminoglycans; Humerus; Misoprostol; Salicylates; Salicylic Acid; Sodium Salicylate | 1991 |
Aspirin, prostaglandin E1 and Quin-2 AM-induced platelet dysfunction: restoration of function by noradrenalin.
Topics: Adult; Alprostadil; Aminoquinolines; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcium; Cell Membrane; Humans; Norepinephrine; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Adrenergic, alpha; Yohimbine | 1990 |
Bilirubin induces platelet aggregation.
Topics: Alprostadil; Aspirin; Bilirubin; Epoprostenol; Humans; In Vitro Techniques; Platelet Aggregation | 1990 |
[Conservative therapy of peripheral arterial occlusive disease].
Topics: Alprostadil; Anticoagulants; Arterial Occlusive Diseases; Aspirin; Dipyridamole; Exercise; Humans; Life Style; Platelet Aggregation Inhibitors | 1990 |
Misoprostol prevents damage to the gastric mucosa by stabilizing the mast cells.
Topics: Alprostadil; Animals; Anti-Ulcer Agents; Aspirin; Ethanol; Gastric Mucosa; Guinea Pigs; Histamine; Histamine Release; Male; Mast Cells; Misoprostol; Stomach Ulcer; Stress, Psychological | 1987 |
Stimulatory effects of vascular prostaglandins on the antiaggregatory activities of pentoxifylline acetylsalicylic acid combinations in vitro.
Topics: Alprostadil; Aspirin; Drug Synergism; Epoprostenol; Humans; Pentoxifylline; Platelet Aggregation; Platelet Aggregation Inhibitors; Theobromine | 1989 |
Effects of aspirin and prostaglandin E1 on in vitro thrombolysis with urokinase. Evidence for a possible role of inhibiting platelet activity in thrombolysis.
Topics: Adult; Alprostadil; Aspirin; Drug Synergism; Female; Fibrinolysis; Humans; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Urokinase-Type Plasminogen Activator | 1989 |
Effect of intragastric pH, prostaglandins and prostaglandin synthesis inhibitors on the release of gastrin and somatostatin into the gastric lumen of anaesthetized rats.
Topics: Alprostadil; Animals; Aspirin; Atropine; Dinoprostone; Electric Stimulation; Gastric Mucosa; Gastrins; Hydrogen-Ion Concentration; Indomethacin; Male; Prostaglandins; Prostaglandins A; Prostaglandins E; Pyloric Antrum; Rats; Rats, Inbred Strains; Somatostatin; Vagus Nerve | 1986 |
Induction of suppression by a murine nonspecific suppressor-inducer cell line (M1-A5). II. The role of prostaglandins.
Topics: Alprostadil; Animals; Aspirin; Cell Line; Dinoprostone; Epoprostenol; Ibuprofen; Immune Tolerance; Kinetics; Lymphokines; Male; Mice; Prostaglandins; Prostaglandins E; Suppressor Factors, Immunologic; T-Lymphocytes, Regulatory | 1986 |
Requirement for prostaglandin E1 (PGE1) for the secretion of suppressor cell inducer factors by spleen cells of tumor-bearing mice.
Topics: Alprostadil; Animals; Aspirin; Fibrosarcoma; In Vitro Techniques; Lymphocyte Activation; Male; Mice; Mice, Inbred DBA; Spleen; Suppressor Factors, Immunologic; T-Lymphocytes, Regulatory | 1986 |
Activation of suppressor cells by low molecular weight factors secreted by spleen cells of tumor-bearing mice: modulatory role of prostaglandins.
Topics: Alprostadil; Animals; Aspirin; Cyclooxygenase Inhibitors; Fibrosarcoma; In Vitro Techniques; Kinetics; Lymphocyte Activation; Male; Mice; Mice, Inbred DBA; Prostaglandins E; Spleen; Suppressor Factors, Immunologic; T-Lymphocytes, Regulatory | 1986 |
The response of human carcinoma cell lines to gamma-linolenic acid with special reference to the effects of agents which influence prostaglandin and thromboxane synthesis.
Topics: Alprostadil; Aspirin; Cell Division; Cell Line; Cell Survival; gamma-Linolenic Acid; Humans; Imidazoles; Indomethacin; Linolenic Acids; Neoplasms; Prostaglandins; Prostaglandins E; Thromboxane A2; Thromboxanes | 1985 |
Prostanoid modulation (mediation?) of certain behavioral effects of ethanol.
Topics: Alcoholism; Alprostadil; Animals; Aspirin; Brain; Ethanol; Fatty Acids; Fatty Acids, Essential; Fatty Acids, Unsaturated; gamma-Linolenic Acid; Humans; Ibuprofen; Indomethacin; Linoleic Acids; Linolenic Acids; Male; Mice; Oenothera biennis; Plant Oils; Prostaglandins; Prostaglandins E; Prostanoic Acids; Substance Withdrawal Syndrome | 1985 |
Effect of triflusal and other salicylic acid derivatives on cyclic AMP levels in rat platelets.
Topics: Alprostadil; Animals; Aspirin; Blood Platelets; Cyclic AMP; Dipyridamole; Drug Interactions; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid | 1986 |
Comparative mucosal protective properties of misoprostol, cimetidine, and sucralfate.
Topics: Alprostadil; Aluminum; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Ethanol; Gastric Mucosa; Indomethacin; Male; Misoprostol; Rats; Stress, Physiological; Sucralfate; Taurocholic Acid | 1986 |
Misoprostol attenuates aspirin-induced changes in potential difference and associated damage in canine gastric mucosa.
Topics: Alprostadil; Animals; Anti-Ulcer Agents; Aspirin; DNA; Dogs; Dose-Response Relationship, Drug; Epithelium; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Membrane Potentials; Misoprostol; Potassium; Stomach Ulcer | 1987 |
Direct platelet-fibrin interaction that does not require platelet activation.
Topics: Adenosine Diphosphate; Alprostadil; Aspirin; Blood Platelets; Egtazic Acid; Fibrin; HEPES; Humans; Hydrogen-Ion Concentration; Kinetics; Nephelometry and Turbidimetry; Oligopeptides; Platelet Aggregation; Polymers; Serotonin | 1987 |
Cytoprotective effect of S-adenosylmethionine compared with that of misoprostol against ethanol-, aspirin-, and stress-induced gastric damage.
Topics: Alprostadil; Animals; Anti-Ulcer Agents; Aspirin; Ethanol; Gastric Mucosa; Gastritis; Intestinal Mucosa; Male; Misoprostol; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Stress, Physiological; Sulfhydryl Compounds | 1987 |
Gastric mucosal blood flow in misoprostol pretreated aspirin-induced ulceration.
Topics: Alprostadil; Animals; Anti-Ulcer Agents; Aspirin; Dogs; Female; Gastric Mucosa; Male; Misoprostol; Research Design; Stomach Ulcer | 1988 |
Effects and interaction studies of triflusal and other salicylic derivatives on cyclooxygenase in rats.
Topics: Alprostadil; Animals; Aorta, Thoracic; Aspirin; Blood Platelets; Drug Interactions; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Vasodilator Agents | 1988 |
The effects of metamizol on prostaglandin synthesis in man.
Topics: Alprostadil; Aminopyrine; Aspirin; Collagen; Dinoprostone; Dipyrone; Gastric Juice; Gastric Mucosa; Humans; In Vitro Techniques; Indomethacin; Kidney; Kinetics; Platelet Aggregation; Prostaglandins; Prostaglandins E; Thromboxanes | 1986 |
Discharge characteristics of receptors with fine afferents from normal and inflamed joints: influence of analgesics and prostaglandins.
Topics: Action Potentials; Afferent Pathways; Alprostadil; Animals; Arthritis; Aspirin; Cats; Dinoprostone; Indomethacin; Inflammation; Knee Joint; Movement; Neural Conduction; Nociceptors; Pain; Prostaglandins E | 1986 |
Primary thrombocythaemia in childhood: symptomatic episodes and their relationship to thromboxane A2, 6-keto-PGE1 and 12-hydroxy-eicosatetraenoic acid production: a case report.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 6-Ketoprostaglandin F1 alpha; Alprostadil; Arachidonate 12-Lipoxygenase; Aspirin; Asthma; Blood Platelets; Child; Eosinophilia; Humans; Hydroxyeicosatetraenoic Acids; Male; Platelet Aggregation; Thrombocytosis; Thromboxane A2 | 1987 |
Is there a prostaglandin involvement in the positive inotropic action of histamine in isolated pregnant rat uterus, apparently mediated via H1-receptors activation?
Topics: Alprostadil; Animals; Aspirin; Chlorpheniramine; Cimetidine; Dinoprost; Dinoprostone; Female; Histamine; Pregnancy; Prostaglandins; Prostaglandins E; Prostaglandins F; Pyrilamine; Quinacrine; Rats; Receptors, Histamine; Receptors, Histamine H1; Stimulation, Chemical; Uterine Contraction | 1987 |
[The effect of benzydamine on prostaglandin synthesis in macrophages].
Topics: Alprostadil; Animals; Aspirin; Benzydamine; Cell Membrane; Dinoprostone; In Vitro Techniques; Macrophages; Piroxicam; Prostaglandins; Prostaglandins E; Pyrazoles; Rats; Rats, Inbred Lew | 1987 |
Effect of a prostaglandin E1 derivative (OP-1206) and acetylsalicylic acid on electrically induced thrombosis in guinea-pig mesenteric artery and its modification by an inhibitor of prostaglandin I2 synthetase, tranylcypromine.
Topics: Alprostadil; Animals; Aspirin; Cytochrome P-450 Enzyme System; Drug Interactions; Electric Stimulation; Epoprostenol; Fibrinolytic Agents; Guinea Pigs; Intramolecular Oxidoreductases; Male; Mesenteric Arteries; Mesenteric Vascular Occlusion; Tranylcypromine; Vasodilator Agents | 1986 |
Hormonal regulation of myoblast proliferation and myotube production in vivo: influence of prostaglandins.
Topics: Alprostadil; Animals; Aspirin; Cell Division; Cell Nucleus; Chick Embryo; Indomethacin; Mitosis; Muscles | 1987 |
Cytoprotective agents in experimental small bowel volvulus.
Topics: Alprostadil; Animals; Aspirin; Ephedrine; Ibuprofen; Indomethacin; Intestinal Obstruction; Intestine, Small; Rats; Rats, Inbred Strains; Superoxide Dismutase | 1987 |
The effects of aspirin and PGE1 on the flow resistance of surface-induced microemboli in human blood.
Topics: Alprostadil; Aspirin; Blood Flow Velocity; Embolism; Filtration; Humans; Micropore Filters; Platelet Aggregation; Pressure; Surface Properties | 1987 |
Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen.
Topics: Alprostadil; Aspirin; Blood Platelets; Cations, Divalent; Collagen; Humans; Molecular Weight; Platelet Adhesiveness; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Conformation | 1986 |
Prostaglandins or prostaglandin like substances are implicated in normal growth and development in oomycetes.
Topics: Alprostadil; Aspirin; Dinoprost; Dose-Response Relationship, Drug; Fatty Acids; Fungi; Indomethacin; Oomycetes; Prostaglandins; Prostaglandins E; Prostaglandins F | 1985 |
The efflux from and the metabolism of 3H-norepinephrine in sow Graafian follicles. Variable involvement of some prostaglandins during two different stages of the sex cycle.
Topics: Alprostadil; Animals; Aspirin; Diestrus; Dinoprost; Dinoprostone; Estrus; Female; In Vitro Techniques; Norepinephrine; Ovarian Follicle; Pregnancy; Proestrus; Prostaglandins E; Prostaglandins F; Prostaglandins, Synthetic; Swine | 1985 |
[Computer-assisted in vivo study of capillary permeability].
Topics: Adolescent; Adult; Aged; Alprostadil; Arterial Occlusive Diseases; Aspirin; Capillary Permeability; Collagen Diseases; Computers; Cyanosis; Dipyridamole; Drug Therapy, Combination; Factor XIII; Female; Heparin; Humans; Male; Microcomputers; Middle Aged; Nails; Phenprocoumon; Raynaud Disease; Rheology; Streptokinase | 1985 |
Suppression of cellular immunity to Listeria monocytogenes by activated macrophages: mediation by prostaglandins.
Topics: Alprostadil; Animals; Aspirin; Cell Adhesion; Female; Immunity, Cellular; Immunosuppression Therapy; Indomethacin; Listeria monocytogenes; Listeriosis; Macrophage Activation; Macrophages; Mice; Prostaglandins; Prostaglandins E | 1985 |
Part of the activating cross-linked immunoglobulin G is internalized by human platelets to sites not accessible for enzymatic digestion.
Topics: Alprostadil; Aspirin; Benzidines; Blood Platelets; Cytochalasin B; Dose-Response Relationship, Drug; Humans; Immunoglobulin G; In Vitro Techniques; Pronase; Tritium | 1986 |
Inhibition of prostaglandin synthesis produces a muscular dystrophy-like myopathy.
Topics: Alprostadil; Animals; Aspirin; Chick Embryo; Indomethacin; Muscles; Muscular Diseases; Muscular Dystrophies; Myofibrils; Prostaglandin Antagonists; Prostaglandins E | 1985 |
Cytoprotective and antisecretory properties of a non-diarrheogenic and non-uterotonic prostacyclin analog: U-68,215.
Topics: Alprostadil; Animals; Anti-Ulcer Agents; Aspirin; Bleeding Time; Blood Pressure; Digestive System; Dogs; Embryo Implantation; Epoprostenol; Female; Gastric Juice; Indomethacin; Intestines; Platelet Aggregation; Rats; Rats, Inbred Strains; Stomach; Uterine Contraction | 1985 |
Platelet accumulation on collagen: drugs which inhibit arachidonic acid metabolism and affect intracellular cyclic AMP levels.
Topics: Alprostadil; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Cyclic AMP; Humans; In Vitro Techniques; Indomethacin; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins; Prostaglandins E; Thromboxanes | 1984 |
Prostaglandin E1 receptors on chick embryo myoblasts.
Topics: Alprostadil; Animals; Aspirin; Cell Aggregation; Cell Fusion; Chick Embryo; Indomethacin; Kinetics; Muscles; Prostaglandins E; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Prostaglandin E; Tunicamycin | 1981 |
Effects of thrombin, acetyl salicylic acid and prostaglandins on spontaneous efflux of norepinephrine and beta-thromboglobulin from platelets in calcium/magnesium deficient environment.
Topics: Alprostadil; Aspirin; Beta-Globulins; beta-Thromboglobulin; Blood Platelets; Calcium; Epoprostenol; Humans; Magnesium; Norepinephrine; Prostaglandins; Prostaglandins E; Thrombin | 1982 |
[Therapy of peripheral arterial occlusive diseases. Round table conference].
Topics: Alprostadil; Angioplasty, Balloon; Anti-Bacterial Agents; Anticoagulants; Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Dipyridamole; Endarterectomy; Exercise Therapy; Fibrinolysis; Humans; Hyperlipidemias; Hypertension; Infusions, Intra-Arterial; Intermittent Claudication; Prostaglandins E; Serotonin Antagonists; Sympathectomy; Thromboxane A2 | 1983 |
A study of beta-adrenergic and prostaglandin receptors in patients with aspirin-induced bronchospasm.
Topics: Adult; Aged; Airway Obstruction; Alprostadil; Aspirin; Bronchial Spasm; Female; Forced Expiratory Volume; Humans; Lymphocytes; Male; Middle Aged; Prostaglandins E; Receptors, Adrenergic; Receptors, Adrenergic, beta; Receptors, Cell Surface; Receptors, Prostaglandin; Vital Capacity | 1982 |
Interaction of prostaglandin and cyclic AMP involved in regulation of platelet function.
Topics: Alprostadil; Aspirin; Blood Platelets; Bucladesine; Cyclic AMP; Humans; Prostaglandins; Prostaglandins E | 1980 |
Effect of prostaglandins and aspirin on active E-rosette formation in patients with multiple sclerosis.
Topics: Adult; Aged; Alprostadil; Arthritis, Rheumatoid; Aspirin; Central Nervous System Diseases; Cyclic AMP; Dinoprostone; Female; Humans; Immunity, Cellular; Male; Middle Aged; Multiple Sclerosis; Prostaglandins; Prostaglandins E; Rosette Formation | 1982 |
Extremely-low-dose aspirin (1 mg per day) renders human platelets more sensitive to antiaggregation prostaglandins.
Topics: Adult; Alprostadil; Aspirin; Drug Synergism; Epoprostenol; Female; Humans; Male; Platelet Aggregation; Prostaglandins; Prostaglandins E | 1984 |
Effect of synthetic prostaglandin E1 analog on aspirin-induced gastric bleeding and secretion.
Topics: Alprostadil; Aspirin; Calcium; Chlorides; DNA; Double-Blind Method; Drug Evaluation; Gastric Juice; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Hydrogen-Ion Concentration; Male; Mucus; Prostaglandins E; Prostaglandins E, Synthetic | 1983 |
Arachidonic acid induces human platelet-fibrin retraction: the role of platelet cyclic endoperoxides.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alprostadil; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Clot Retraction; Epoprostenol; Fatty Acids, Unsaturated; Fibrin; Humans; Imidazoles; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins D; Prostaglandins E; Prostaglandins H; Prostaglandins, Synthetic; Thromboxane B2 | 1982 |
Laxative-like effects of nonsteroidal anti-inflammatory drugs on intestinal fluid movement and membrane integrity.
Topics: Alprostadil; Animals; Anti-Inflammatory Agents; Aspirin; Body Fluids; Cathartics; Cricetinae; Diarrhea; Dinoprostone; Erythrocyte Membrane; Flufenamic Acid; Hemolysis; Indomethacin; Intestinal Mucosa; Intestines; Male; Meclofenamic Acid; Mefenamic Acid; Mesocricetus; Prostaglandin Antagonists; Prostaglandins E | 1982 |
Role of prostaglandins in rat pineal neuroeffector junction. Changes in melatonin and norepinephrine release in vitro.
Topics: Alprostadil; Animals; Aspirin; Dinoprost; Dinoprostone; Indomethacin; Male; Mefenamic Acid; Melatonin; Norepinephrine; Pineal Gland; Potassium; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains | 1982 |
Analgesics and asthma.
Topics: Alprostadil; Analgesics; Aspirin; Asthma; Dinoprost; Dinoprostone; Drug Hypersensitivity; Humans; Prostaglandins; Prostaglandins E; Prostaglandins F; SRS-A | 1982 |
Prostaglandins and platelet aggregation.
Topics: Alprostadil; Animals; Arteries; Aspirin; Blood Platelets; Cattle; Epoprostenol; Humans; Platelet Aggregation; Prostaglandin D2; Prostaglandins; Prostaglandins D; Prostaglandins E; Thromboxane B2 | 1981 |
Structural-functional modulation of mucin secretory patterns in the gastrointestinal tract.
Topics: Alprostadil; Animals; Aspirin; Colon; Cytochalasin B; Glucose; Jejunum; Male; Microscopy, Electron; Mucins; Prostaglandins E; Rats; Rats, Inbred Strains; Sulfates | 1981 |
Effects of acetylsalicylic acid and prostaglandin on endotoxin-induced pulmonary platelet sequestration.
Topics: Alprostadil; Animals; Aspirin; Blood Platelets; Dogs; Drug Therapy, Combination; Endotoxins; Female; Lung; Male; Platelet Aggregation; Prostaglandins E; Shock, Septic | 1981 |
Modulation of the inhibitory action of prostaglandin E1 on platelet aggregation in rats: a study with ticlopidine, aspirin, dipyridamole and sulfinpyrazone.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Aspirin; Dipyridamole; Male; Phosphorylation; Platelet Aggregation; Prostaglandins E; Rats; Rats, Inbred Strains; Sulfinpyrazone; Thiophenes; Ticlopidine | 1982 |
Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells.
Topics: Adolescent; Adult; Alprostadil; Amino Acid Sequence; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Basophils; Bryostatins; Calcimycin; Colforsin; Complement C5a; Histamine Release; Humans; Immunoglobulin E; Indomethacin; Lactones; Leukotriene C4; Lung; Macrolides; Mast Cells; Middle Aged; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Prostaglandin D2; Skin; Sulfonamides; Tetradecanoylphorbol Acetate | 1993 |
Role of cyclic nucleotides in rapid platelet adhesion to collagen.
Topics: Adenylyl Cyclases; Alprostadil; Antigens, CD; Apyrase; Aspirin; Blood Platelets; Collagen; Creatine Kinase; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Humans; Integrin beta1; Integrins; Nitroprusside; Platelet Adhesiveness | 1994 |
Insulin-induced release of plasminogen activator from human blood platelets.
Topics: alpha-2-Antiplasmin; Alprostadil; Aspirin; Blood Platelets; Bucladesine; Calcium Chloride; Cell Membrane; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Humans; In Vitro Techniques; Insulin; Kinetics; Plasminogen; Plasminogen Activator Inhibitor 1; Plasminogen Activators; Platelet Aggregation Inhibitors; Receptor, Insulin; Recombinant Proteins; Theophylline; Time Factors | 1995 |
The inability of low-molecular-weight dextran, aspirin, and prostaglandin E1 to inhibit monolayer platelet adhesion to polyethylene.
Topics: Alprostadil; Analysis of Variance; Antibodies, Monoclonal; Aspirin; Dextrans; Humans; In Vitro Techniques; Indium Radioisotopes; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Polyethylenes | 1993 |
Acetylsalicylic acid (ASA) protects the prostaglandin-cAMP-system of human hypernephroma cells against irradiation-induced alterations.
Topics: Alprostadil; Aspirin; Carcinoma, Renal Cell; Cyclic AMP; Dinoprostone; Female; Humans; Iloprost; Kidney Neoplasms; Male; Middle Aged; Receptors, Drug; Receptors, Prostaglandin E; Tumor Cells, Cultured | 1993 |
Effect of beraprost sodium, a stable prostacyclin analogue, on pulmonary thromboembolism in mice.
Topics: Administration, Oral; Alprostadil; Animals; Aspirin; Bridged Bicyclo Compounds; Collagen; Diltiazem; Drug Evaluation, Preclinical; Epinephrine; Epoprostenol; Fatty Acids, Monounsaturated; Fibrinolytic Agents; Heparin; Hydralazine; Injections, Intravenous; Isosorbide Dinitrate; Male; Mice; Nifedipine; Nitroprusside; Platelet Aggregation Inhibitors; Pulmonary Embolism; Superoxide Dismutase; Vasodilator Agents | 1995 |
Management of cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia using prostaglandin E1 and aspirin.
Topics: Aged; Alprostadil; Angina, Unstable; Aspirin; Cardiopulmonary Bypass; Coronary Artery Bypass; Female; Heparin; Humans; Intraoperative Care; Myocardial Infarction; Platelet Aggregation; Preoperative Care; Thrombocytopenia | 1994 |
Purification and characterization of L-amino acid oxidase from king cobra (Ophiophagus hannah) venom and its effects on human platelet aggregation.
Topics: Alprostadil; Amino Acid Oxidoreductases; Animals; Antimycin A; Aspirin; Blood Coagulation Tests; Blood Platelets; Catalase; Chromatography, Gel; Chromatography, Ion Exchange; Drug Interactions; Edetic Acid; Elapid Venoms; Electrophoresis, Polyacrylamide Gel; Heparin; Hirudins; Humans; Hydrogen Peroxide; Indomethacin; Isoelectric Point; L-Amino Acid Oxidase; Molecular Weight; Nitroprusside; Platelet Aggregation; Quinacrine; Thromboxane A2; Verapamil | 1994 |
Prostaglandins and arterial wall lipid metabolism--in vitro, ex-vivo and in-vivo radioisotopic studies.
Topics: Alprostadil; Animals; Arteries; Aspirin; Cholesterol; Cyclic AMP; Epoprostenol; Humans; In Vitro Techniques; Iodine Radioisotopes; Isradipine; Kinetics; Lipid Metabolism; Lipids; Lipoproteins, LDL; Male; Prostaglandin Antagonists; Prostaglandins; Prostaglandins E, Synthetic; Rabbits | 1994 |
Mechanism of aspirin induced neural tube defect in chick embryo.
Topics: Alprostadil; Animals; Aspirin; Chick Embryo; Dinoprost; Neural Tube Defects | 1994 |
Aspirin-like drugs inhibit neuronally evoked responses in isolated guinea-pig ileum.
Topics: Acetylcholine; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzydamine; Cyclooxygenase Inhibitors; Guinea Pigs; Ileum; Indomethacin; Isotonic Contraction; Male; Muscle, Smooth; Naloxone; Parasympathetic Nervous System; Receptors, Opioid; Salicylates; Salicylic Acid; Sincalide | 1993 |
Platelet adhesivity to subendothelium is influenced by polymorphonuclear leukocytes: studies with aspirin and salicylate.
Topics: 6-Ketoprostaglandin F1 alpha; Alprostadil; Animals; Aspirin; Blood Platelets; Cell Communication; Cyclooxygenase Inhibitors; Endothelium, Vascular; Humans; Lipoxygenase Inhibitors; Neutrophils; Platelet Adhesiveness; Rabbits; Salicylates; Salicylic Acid; Thromboxane B2 | 1993 |
Antithrombotic effects of TAK-029, a novel GPIIb/IIIa antagonist, in guinea pigs: comparative studies with ticlopidine, clopidogrel, aspirin, prostaglandin E1 and argatroban.
Topics: Alprostadil; Animals; Arginine; Aspirin; Clopidogrel; Dogs; Fibrinolytic Agents; Guanidines; Guinea Pigs; Humans; Macaca fascicularis; Male; Pipecolic Acids; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyrazines; Sulfonamides; Ticlopidine | 1996 |
Anti-inflammatory effects of beraprost sodium, a stable analogue of PGI2, and its mechanisms.
Topics: Alprostadil; Animals; Anti-Inflammatory Agents; Aspirin; Cell Membrane Permeability; Collagen; Dose-Response Relationship, Drug; Edema; Endothelium, Vascular; Epinephrine; Epoprostenol; Lung; Male; Mice; Organ Size; Pulmonary Embolism; Rats; Rats, Wistar; Serotonin | 1997 |
Triggering of beta 1-integrin chain induces platelet adhesion to cultured endothelium.
Topics: Alprostadil; Animals; Antibodies, Monoclonal; Aspirin; Azepines; Blood Platelets; Cells, Cultured; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Matrix Proteins; Humans; Integrin beta1; Mice; Mice, Inbred BALB C; Nitroprusside; P-Selectin; Platelet Adhesiveness; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; Staurosporine; Thienopyridines; Triazoles | 1997 |
Basal concentrations of free and esterified monohydroxylated fatty acids in human blood platelets.
Topics: Alprostadil; Anticoagulants; Aspirin; Blood Platelets; Chelating Agents; Cyclooxygenase Inhibitors; Edetic Acid; Esters; Fatty Acids; Fatty Acids, Nonesterified; Gas Chromatography-Mass Spectrometry; Humans; Hydrogenation; Hydroxy Acids; Platelet Aggregation Inhibitors | 1997 |
[The use of aspirin in patients with primary pulmonary hypertension].
Topics: Adult; Alprostadil; Aspirin; Calcium Channel Blockers; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypertension, Pulmonary; Isradipine; Male; Platelet Aggregation Inhibitors; Time Factors; Vasodilator Agents | 1998 |
Antiplatelet agents in tissue factor-induced blood coagulation.
Topics: Abciximab; Adult; Alprostadil; Animals; Antibodies, Monoclonal; Antithrombin III; Aspirin; Blood Coagulation; Dipyridamole; Eptifibatide; Fibrinopeptide A; Humans; Immunoglobulin Fab Fragments; Mice; Osteonectin; Partial Thromboplastin Time; Peptide Hydrolases; Peptides; Plant Proteins; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Proteins; Prothrombin Time; Receptors, Thrombin; Thromboplastin | 2001 |
Fc-receptor dependent platelet aggregation induced by monoclonal antibodies against platelet glycoprotein Ib or von Willebrand factor.
Topics: Adenosine Triphosphate; Alprostadil; Animals; Antibodies, Monoclonal; Aspirin; Blood Platelets; Humans; Immunoglobulin Fab Fragments; Mice; Mice, Inbred BALB C; Phosphorylation; Phosphotyrosine; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Protein Processing, Post-Translational; Receptors, IgG; Signal Transduction; von Willebrand Factor | 2001 |
Hypothermia-induced platelet aggregation in heparinized flowing human blood: identification of a high responder subpopulation.
Topics: Alprostadil; Anemia, Hemolytic, Autoimmune; Aspirin; Blood Cell Count; Citric Acid; Cold Temperature; Edetic Acid; Filtration; Hemorheology; Heparin; Humans; Hypothermia; Light; Models, Biological; Platelet Aggregation; Platelet Aggregation Inhibitors; Pressure; Protamines; Scattering, Radiation; Tirofiban; Tyrosine | 2002 |
The effect of aspirin and prostaglandin E(1) on the patency of microvascular anastomosis in the rats.
Topics: Administration, Oral; Alprostadil; Anastomosis, Surgical; Animals; Aspirin; Carotid Arteries; Carotid Artery Thrombosis; Disease Models, Animal; Male; Microcirculation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Vascular Patency | 2001 |
Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility.
Topics: Alprostadil; Animals; Aspirin; Cell Membrane; Cryopreservation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Isoenzymes; Male; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Resveratrol; Semen; Semen Preservation; Sperm Motility; Spermatozoa; Stilbenes; Sulfonamides; Tolmetin; Turkeys | 2003 |
Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs.
Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Calpain; Cell Line, Tumor; Chondrocytes; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Diclofenac; Dinoprostone; Humans; Nitrobenzenes; Phenylpropionates; Prostaglandin Antagonists; Sulfonamides; Tumor Necrosis Factor-alpha; Up-Regulation; Xanthones | 2004 |
The role of insulin dependent NO synthesis in the impaired production of maspin in human breast cancer.
Topics: Aged; Alprostadil; Aspirin; Binding, Competitive; Breast Neoplasms; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Genes, Tumor Suppressor; Humans; Insulin; Middle Aged; Neutrophils; Nitric Oxide; Receptor, Insulin; Sensitivity and Specificity; Serpins; Time Factors; Up-Regulation | 2006 |
Interaction of inflammation, thrombosis, aspirin and enoxaparin in CNS experimental antiphospholipid syndrome.
Topics: Alprostadil; Analysis of Variance; Animals; Antiphospholipid Syndrome; Aspirin; Behavior, Animal; beta 2-Glycoprotein I; Central Nervous System; Disease Models, Animal; Enoxaparin; Enzyme-Linked Immunosorbent Assay; Exploratory Behavior; Female; Fibrinolytic Agents; Mice; Mice, Inbred BALB C; Phospholipids; Thrombosis; Tumor Necrosis Factor-alpha | 2008 |
A case of widespread livedoid vasculopathy with pain but no systemic symptoms.
Topics: Adult; Alprostadil; Aspirin; Biopsy; Blood Sedimentation; C-Reactive Protein; Female; Humans; Hyperesthesia; Lymphocytes; Platelet Aggregation Inhibitors; Skin; Skin Diseases, Vascular; Ticlopidine; Vasodilator Agents | 2008 |
[Digital ischemia in a gardener: is rose cutting a vascular risk factor?].
Topics: Alprostadil; Aneurysm; Anticoagulants; Aspirin; Diagnosis, Differential; Female; Finger Injuries; Fingers; Gardening; Hobbies; Humans; Ischemia; Magnetic Resonance Angiography; Middle Aged; Nadroparin; Photoplethysmography; Platelet Aggregation Inhibitors; Pulse; Radial Artery; Recurrence; Risk Factors; Treatment Outcome; Ultrasonography, Doppler, Color; Vasodilator Agents | 2008 |
Livedoid vasculopathy with underlying subcutaneous necrotizing venulitis in an asymptomatic hepatitis B virus carrier: is livedoid vasculopathy a true nonvasculitic disorder?
Topics: Administration, Oral; Adult; Alprostadil; Aspirin; Biopsy; Carrier State; Combined Modality Therapy; Drug Therapy, Combination; Hepatitis B; Humans; Infusions, Intravenous; Livedo Reticularis; Male; Necrosis; Skin; Spondylitis, Ankylosing; Stockings, Compression; Subcutaneous Tissue; Treatment Outcome; Vasculitis; Venules | 2009 |
[The inhibition effect of a synthetic analogue of prostaglandin E1 to the provocation by aspirin in the patients of WDEIA].
Topics: Adult; Alprostadil; Anaphylaxis; Aspirin; Exercise; Female; Gliadin; Humans; Middle Aged; Misoprostol; Premedication; Wheat Hypersensitivity | 2009 |
Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin.
Topics: Adenosine Diphosphate; Aged; Alprostadil; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Diabetes Mellitus; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Ticlopidine | 2013 |
Spontaneous platelet aggregation in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Alprostadil; Antibodies; Aspirin; Blood Platelets; Clopidogrel; Humans; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Ticlopidine; von Willebrand Factor | 2013 |
In vivo administration of ritonavir worsens intestinal damage caused by cyclooxygease inhibitors.
Topics: Alprostadil; Animals; Apoptosis; Aspirin; Chemokine CCL2; Cyclooxygenase Inhibitors; Dinoprostone; Drug Synergism; HIV Protease Inhibitors; HT29 Cells; Humans; Integrin alpha1beta1; Intestinal Mucosa; Intestine, Small; Ketoprofen; Mice; Mice, Inbred C57BL; Misoprostol; Naproxen; Nitric Oxide Synthase Type II; Ritonavir; RNA, Messenger; Tumor Necrosis Factor-alpha | 2014 |
Low E-prostanoid 2 receptor levels and deficient induction of the IL-1β/IL-1 type I receptor/COX-2 pathway: Vicious circle in patients with aspirin-exacerbated respiratory disease.
Topics: Adult; Aged; Alprostadil; Aspirin; Asthma, Aspirin-Induced; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Female; Fibroblasts; Humans; Interleukin-1beta; Intramolecular Oxidoreductases; Male; Middle Aged; Nasal Mucosa; Nasal Polyps; Prostaglandin-E Synthases; Receptors, Interleukin-1 Type I; Receptors, Prostaglandin E, EP2 Subtype; RNA, Messenger | 2016 |
Altered expression and signalling of EP2 receptor in nasal polyps of AERD patients: role in inflammation and remodelling.
Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Proliferation; Cyclic AMP; Dinoprostone; Disease Progression; Down-Regulation; Female; Fibroblasts; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; Male; Middle Aged; Nasal Mucosa; Nasal Polyps; Receptors, Prostaglandin E; Respiratory Tract Diseases; Signal Transduction | 2016 |
Effect of Drugs Associated With Bleeding Tendency on the Complications and Outcomes of Transforaminal Epidural Steroid Injection.
Topics: Aged; alpha-Cyclodextrins; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Clopidogrel; Female; Follow-Up Studies; Hemorrhage; Humans; Injections, Epidural; Male; Middle Aged; Pain; Pain Measurement; Platelet Aggregation Inhibitors; Retrospective Studies; Steroids; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Reduced platelet aggregation in women after intercourse: a possible role for the cyclooxygenase pathway.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Alprostadil; Aspirin; Coitus; Condoms; Female; Humans; Indomethacin; Male; Middle Aged; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Semen | 2017 |
Comparison of acetylsalicylic acid and clopidogrel non-responsiveness assessed by light transmittance aggregometry and PFA-100® in patients undergoing neuroendovascular procedures.
Topics: Adenosine Diphosphate; Aged; Alprostadil; Aspirin; Blood Coagulation Tests; Blood Platelets; Clopidogrel; Collagen; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Reproducibility of Results; Stents; Technology Assessment, Biomedical; Thrombosis; Time Factors | 2020 |
Effects of Antiplatelet Drugs on Platelet-Dependent Coagulation Reactions.
Topics: Alprostadil; Aspirin; Blood Coagulation; Blood Platelets; Collagen; Fibrin; Humans; Platelet Aggregation Inhibitors; Thrombin; Ticagrelor | 2023 |