aspirin has been researched along with adenosine diphosphate in 854 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 400 (46.84) | 18.7374 |
| 1990's | 109 (12.76) | 18.2507 |
| 2000's | 190 (22.25) | 29.6817 |
| 2010's | 127 (14.87) | 24.3611 |
| 2020's | 28 (3.28) | 2.80 |
| Authors | Studies |
|---|---|
| Barr, HM; Camden, J; Fischer, B; Shai, E; Varon, D; Weisman, GA; Yelovitch, S | 1 |
| Jobin, F | 1 |
| Bertoni, MP; De Gaetano, G; Roncaglioni, MC; Tonolli, MC | 1 |
| Lefort, J; Vargaftig, BB | 2 |
| Kinlough-Rathbone, RL; Mustard, JF; Packham, MA; Perry, DW | 1 |
| Kubisz, P; Suranová, J | 1 |
| Dougherty, JH; Levy, DE; Weksler, BB | 1 |
| Isselhard, W; Lauterjung, KL; Welter, HF | 1 |
| Aleksandrova, NA; Bokarev, IN; Kabaeva, EV; Kun, IS; Marcukova, EV; Olbinskaja, LI; Ovcinnikova, LV | 1 |
| Heine, H; Heinemann, L; Norden, C; Stepanauskas, M | 1 |
| Diamantis, W; Haertlein, B; Kohlhepp, WC; Melton, J; Sofia, RD | 1 |
| Alexander, B; Leonardi, RG; Parts, A; White, F | 1 |
| Inamasu, M; Morita, T; Sasaki, Y; Shinjo, A | 1 |
| Boyd, J; Kindness, G; Long, WF; Williamson, FB | 1 |
| Mongeau, JG; O'Reagan, SO; Rivard, GE; Robitaille, PO | 1 |
| Davis, JW; Yue, KT | 1 |
| Dechavanne, M; Lagarde, M; Thouverez, JP; Verry, M | 1 |
| Hoder, A; Losert, W; Scholz, Ch | 1 |
| Rosenberg, JC; Sell, TL | 1 |
| CoFrancesco, E; Deliliers, GL; Ferrari, R; Pogliani, E; Pozzoli, E; Praga, C | 1 |
| Lindon, JN; Rodvien, R; Salzman, EW | 1 |
| Haslam, RJ | 1 |
| Guccione, MA; Kinlough-Rathbone, RL; Mustard, JF; Packham, MA; Perry, DW | 1 |
| Salzman, EW | 1 |
| Matsuo, T; Ohki, Y | 1 |
| Fujitani, B; Shimizu, M; Tsuboi, T; Yoshida, K | 1 |
| Elezović, I; Mijović, A; Rolović, Z | 1 |
| Coccia, PF; Gerrard, JM; Krivit, W; Nesbit, ME; Ramsay, NK; Rao, GH; Shapiro, RS; Stoddard, SF; White, JG | 1 |
| Smith, C; Ts'ao, CH | 1 |
| Cook, MA; Lane, IJ; Mills, DG; Otton, JD; Philp, RB | 1 |
| Mustard, JF; Packham, MA | 2 |
| Cazenave, JP; Kinlough-Rathbone, RL; Mustard, JF; Packham, MA; Reimers, HJ | 1 |
| Bourgain, RH | 1 |
| Haycraft, D; Hoak, JC; Nordøy, A; Svensson, B; Wiebe, D | 1 |
| Benveniste, J; Chignard, M; Le Couedic, JP; Tence, M; Vargaftig, BB | 1 |
| Caen, JP; Wautier, JL | 1 |
| Galluzzo, TS; Holly, CM; Serieno, MA; Ts'ao, CH | 1 |
| Ardlie, NG; Jakubowski, JA | 1 |
| de Gaetano, G; Di Minno, G; Silver, MJ | 1 |
| Gerrard, JM; Rao, GH; White, JG | 1 |
| Heller, MJ; Hyman, BT; Klotz, IM; Shishido, RY; Walder, JA | 1 |
| Aamodt, R; Capurro, NL; Epstein, SE; Goldstein, RE; Marr, KC | 1 |
| Cines, DB; Colman, RW; Schreiber, AD; Zmijewski, C | 1 |
| Broekman, MJ; Kaplan, KL; Mosesson, MW; Zucker, MB | 1 |
| Goldsmith, HL; Karino, T | 1 |
| Grant, B; Katz, J; Lindner, C; Meyers, KM | 1 |
| Ku, CS; Wu, KK | 1 |
| Colella, LM; D'Arcangelo, C; Del Principe, D; Del Vecchio, S; Gabriotti, M; Mastracchio, F; Menichelli, A; Tallarida, BM | 1 |
| Iatridi, IS; Iatridis, PG; Iatridis, SG; Kyrkou, KA; Markidou, SG | 1 |
| Stuart, MJ | 1 |
| Capetti, P; Piro, F | 1 |
| Chediak, J; Cohen, I; Maxey, B; Telfer, MC; Vander Laan, B | 1 |
| Louis, G; Rossi, EC | 1 |
| Jenkins, CS; Oosterhuis, H; Prenger, D; ten Cate, JW; Vos, J | 1 |
| Carter, RD; Honour, AJ; Mann, JI | 1 |
| Chignard, M; Lefort, J; Vargaftig, BB | 1 |
| McIntyre, BA; Philp, RB | 1 |
| Ayyub, GE; Bikhazi, AB | 1 |
| Hoak, JC; Nordøy, A; Svensson, B | 1 |
| Ehrman, M; Frojmovic, M; Toth, E | 1 |
| Bonaccorsi, A; de Gaetano, G; Dejana, E | 1 |
| Bruseghini, L; Vilageliu, J | 1 |
| Aikawa, T; Goto, M; Oishi, T; Suzuki, T; Takano, S; Tamura, O | 1 |
| Matsuo, T; Ohoki, Y | 1 |
| Ingerman, CM; Silver, MJ; Smith, JB | 2 |
| Fobian, JE; Garancis, JC; Hussey, CV; Wang, TY | 1 |
| Claeys, M; Lambelin, G; Roba, J | 1 |
| Colwell, JA; Halushka, PV; Levine, J; Nair, RM; Sagel, J; Sarji, K | 1 |
| Boisseau, M; Bouloumie, J; Bricaud, H; Broustet, JP; Emeriau, JP | 1 |
| Braunstein, KM; Colwell, JA; Eurenius, K; Kleinfelder, J; Sarji, KE; Schraibman, HB | 1 |
| Clowes, AW; Karnovsky, MJ | 1 |
| Ts'ao, CH | 1 |
| Hockaday, TD; Honour, AJ; Mann, JI | 1 |
| Nyman, D | 1 |
| Jordan, P; Kling, P; Minsker, DH; Welch, T | 1 |
| Guyton, JR; Willerson, JT | 1 |
| Genders, T; Haanen, C; Imandt, L; Wessels, H | 1 |
| Melzer, G; Nitz, RE; Resag, K | 1 |
| Champion, LA; Luddy, RE; Schindler, S; Schwartz, AD | 1 |
| Garcia, CA; Kageler, WV; Moake, JL | 1 |
| Danilevicius, Z | 1 |
| Boni, P; Leone, G; Vincenti, A | 1 |
| Ts'ao, C | 1 |
| Jörgensen, TG; Nielsen, HH; Olesen, HP; Weis-Fogh, US | 1 |
| Bonardi, G; Montanari, C; Prandoni, E; Sala, P | 1 |
| Ulutin, ON; Yardimci, TU | 1 |
| Jörgensen, TG; Olesen, HP; Weis-Fogh, US | 1 |
| Weiss, HJ | 5 |
| Baumgartner, HR; Tschopp, TB; Weiss, HJ | 1 |
| Arfors, KE; Bergqvist, D; Tangen, O | 1 |
| Komp, DM | 1 |
| Anderson, LK; Kardinal, CG; Wegener, LT | 1 |
| Day, HJ; Holmsen, H; Lages, B; Scrutton, MC; Setkowsky, CA; Weiss, HJ | 1 |
| Colwell, JA; Crook, L; Laimins, M; Sagel, J | 1 |
| Vaisrub, S | 1 |
| Klose, HJ; Rieger, H; Schmid-Schönbein, H | 1 |
| Afifi, N; Badr, M; Hassanein, AA | 1 |
| De Clerck, F; Reneman, R; Vermylen, J | 1 |
| Arkel, YS; Schrogie, JJ; Williams, R | 1 |
| Levine, PH | 1 |
| Brand, H; Kuhn, D; Weiss, HJ; Willis, AL | 1 |
| Gerrard, JM; White, JG | 1 |
| de Gaetano, G; Lambelin, G; Lansen, J; Miragliotta, G; Roncucci, R | 1 |
| Crowley, HJ; Dalton, C; Shtacher, G | 1 |
| Morell, J; Rafanell, JG; Uriach, J | 1 |
| Bochner, F; Duncan, EM; Lloyd, JV; Rodgers, SE; Vanags, DM | 1 |
| Carroll, RC; Rubinstein, E; Urso, I | 1 |
| Cabusao, EA; Garfield, JD; Greisler, HP; Henderson, SC; Kim, DU; Tattersall, CW | 1 |
| Mahler, M; Seifert, W; Spiegel, B; Staks, T | 1 |
| Ardlie, NG; Bartlett, MR; McGuiness, JA; Selley, ML | 1 |
| Penny, WF; Ware, JA | 1 |
| Barrow, DV; Gross, PL; Packham, MA; Rand, ML | 2 |
| Akopov, SE; Gabrielian, ES | 1 |
| Imai, S; Ino, T; Mitsuoka, Y; Momo, K; Nakamura, K; Ohkubo, H; Someya, K; Tachiiri, T | 1 |
| Boucheix, C; Carroll, RC; Rubinstein, E; Urso, I | 1 |
| Bonnar, J; Norris, LA; Sheppard, BL | 1 |
| Akopov, SS; Gabrielian, ES; Grigorian, GS | 1 |
| Aznar, J; Broekman, MJ; Marcus, AJ; Martinez-Sales, V; Portoles, M; Safier, LB; Santos, MT; Valles, J | 1 |
| Jimenez, AH; Muller, JE; Stubbs, ME; Tofler, GH; Williams, GH; Winther, K | 1 |
| Boudreaux, MK; Dillon, AR; Ravis, WR; Sartin, EA; Spano, JS | 1 |
| Inoue, M; Iwane, Y; Kobune, K; Kudo, T; Morikawa, M; Takanami, Y; Tsuboi, M | 1 |
| Fukuroi, T; Iwata, K; Kawakatsu, T; Kido, H; Nagata, H; Nomura, S; Soga, T; Suzuki, M; Yamaguchi, K; Yanabu, M | 1 |
| Bentz, M; Berceli, SA; Borovetz, HS; Dickson, C; Hribar, S; Janosky, J; Johnson, PC; Sheppeck, RA; White, J | 1 |
| Takahashi, O | 1 |
| Cambridge, H; Hooke, RE; Lees, P; Russell, CS | 1 |
| DeCenzo, MT; Kang, J; Saitoh, M; Slayter, HS; Smith, M; Ware, JA; Watkins, SC | 1 |
| Cattaneo, M; Lecchi, A; Mannucci, PM; Tenconi, PM | 1 |
| Broekman, MJ; Eiroa, AM; Hajjar, KA; Islam, N; Marcus, AJ; Safier, LB; Ullman, HL | 1 |
| Huang, ZS; Lee, TK | 1 |
| Aznar, J; Broekman, MJ; Eiroa, AM; Islam, N; Marcus, AJ; Safier, LB; Santos, MT; Ullman, HL; Valles, J | 1 |
| Katayama, Y; Kobayashi, K; Matsuyama, T; Sakata, T; Takada, T | 1 |
| Kakishita, E; Nagai, K; Oura, Y; Suehiro, A | 1 |
| Pinto, A; Sorrentino, L; Sorrentino, R | 1 |
| Hakenkamp, K; Ryan, WL; Sullivan, E | 1 |
| Furui, H; Furumichi, T; Hayashi, H; Saito, H; Suzuki, T; Yamada, Y; Yamauchi, K; Yokota, M | 1 |
| Higashihara, M; Kariya, T; Kume, S; Matsumoto, Y; Ozaki, Y; Yatomi, Y | 1 |
| Fears, R; Ferres, H; Greenwood, HC | 1 |
| Derian, CK; Friedman, PA; Gould, RJ | 1 |
| England, PJ; Hallam, TJ; Maguire, J; Moores, K; Murray, KJ; Reeves, ML; Rink, TJ; Simpson, AW | 1 |
| Bochner, F; Duncan, EM; Lloyd, JV; Siebert, DM; Somogyi, AA; Wilson, KM | 1 |
| Kinlough-Rathbone, RL; Mustard, JF; Packham, MA; Vickers, JD | 1 |
| al-Harthy, SS; al-Mashhadani, SA; Gader, AM | 1 |
| Boucheix, C; Carroll, RC; Worthington, RE | 1 |
| Davidson, BC; Haggan, J | 1 |
| Anne, MC; de Sèze, O; Doutremepuich, C; Lalanne, MC; Le Roy, D | 1 |
| Etscheid, G; Kirchhof, B; Kirchhof, U | 1 |
| Gralnick, HR; McKeown, LP; Williams, SB | 1 |
| Loscalzo, J; Vaughan, DE | 1 |
| Stürzebecher, S; Witt, W | 1 |
| Barradas, MA; Dandona, P; Hoffbrand, AV; Jeremy, JY; Kontoghiorghes, GJ; Mikhailidis, DP | 1 |
| Palma-Carlos, AG; Palma-Carlos, ML; Santos, MC | 1 |
| Collen, D; Coller, BS; Finkelstein, D; Gimple, LW; Gold, HK; Johns, JA; Leinbach, RC; Werner, W; Yasuda, T; Ziskind, AA | 1 |
| Bleifeld, W; Kupper, W; Schuster, O; Terres, W | 1 |
| Arosio, E; Guzzo, P; Lechi, A; Lechi, C; Minuz, P; Paluani, F; Sinigaglia, D | 1 |
| Gralnick, HR; Parker, RI | 1 |
| Bizzi, B; Castagnola, M; De Candia, E; De Cristofaro, R; Di Cera, E; Landolfi, R | 1 |
| Gentry, PA; Liptrap, RM; Niemuller, C; Ross, ML | 1 |
| Holmsen, H; Lie, RT; Thorsen, T | 1 |
| Chen, YC; Huang, ZS; Kuo, TL; Lee, TK; Lien, IN; Liu, MC | 1 |
| Heine, H; Misselwitz, F; Norden, C | 2 |
| Lassing, I; Lindberg, U | 1 |
| Bonaventi, C; Caneschi, S; Finzi, F; Tito, P | 1 |
| Bonaventi, C; Caneschi, S; Finzi, F | 1 |
| Hammerschmidt, DE; Husak, M; Jacob, HS; Jeanneret, C; Lobell, M | 1 |
| Barzaghi, G; Cerletti, C; de Gaetano, G | 1 |
| Corkey, BE; Douglas, SD; Kilpatrick, LE; Polin, RA | 1 |
| Dangelmaier, CA; Holmsen, H; Lages, B; Weiss, HJ | 1 |
| Armstrong, RA; Jones, RL; Wilson, NH | 1 |
| Cerbone, AM; Cirillo, F; Di Minno, G; Mancini, M; Mattioli, PL; Pannain, M; Postiglione, A | 1 |
| Buttrick, PM; Forscher, CA; Mueller, HS; Sussman, II | 1 |
| Fiegler, M; Jávor, T; Mózsik, G; Nagy, L; Patty, I; Tárnok, F | 1 |
| Higashihara, M; Kariya, T; Kume, S; Ohashi, T; Takahata, K; Tanabe, A; Yatomi, Y | 1 |
| Kinlough-Rathbone, RL; Mustard, JF; Winocour, PD | 1 |
| Johnson, PC; Salzman, EW; Smith, M; Ware, JA | 1 |
| Emms, H; Lewis, GP | 1 |
| Bernard, H; Boisseau, MR; Casadebaig, F; Dupin, JP; Gravier, D | 1 |
| Bellido, I; Camara, S; de la Cruz, JP; Martos, F; Sanchez de la Cuesta, F | 1 |
| Ishikawa, S; Manabe, S; Wada, O | 1 |
| Malmgren, R | 1 |
| Frölich, JC; Küster, LJ | 1 |
| Bellido, I; Camara, S; Carrasco, T; de la Cruz, JP; Sanchez de la Cuesta, F | 1 |
| Adnot, S; Joseph, D; Vargaftig, BB | 1 |
| Hu, SJ; Jen, CJ | 1 |
| Herold, M; Kogelnig, R; Kunz, F; Zwierzina, WD | 1 |
| Andries, R; Bourgain, RH; Braquet, P; Decuyper, K | 1 |
| Allen, BT; Anderson, CB; Freeman, MB; McGoff, MA; Sicard, GA; Valentin, LI | 1 |
| Hamasaki, Y; Ichimaru, T; Miyazaki, S; Tasaki, H | 1 |
| Davì, G; Gallo, V; Mazza, A; Palumbo, MG; Pinto, A; Strano, A | 1 |
| Hellums, JD; Moake, JL; Nolasco, L; Stathopoulos, NA; Turner, NA | 1 |
| Gago, J; Hevia, A; Reche, A; Serrano, JS | 1 |
| Chen, YC; Huang, ZS; Lee, TK; Lien, IN; Liu, MC | 1 |
| Dhawan, BN; Puri, V; Srimal, RC; Srivastava, R | 1 |
| Agmon, J; Cohen, IJ; Fuchs, J; Jerushalmy, Z; Kaplinski, C; Krugliak, J; Rotenberg, Z; Stark, B; Vogel, R; Weinberger, I | 1 |
| Calder, AA; Forbes, CD; Greer, IA; Walker, JJ | 1 |
| Lazzari, MA; Woods, AI | 1 |
| Chen, YC; Kuo, TL; Lee, TK | 1 |
| Schrör, K; Verheggen, R | 1 |
| Crawford, N; Lampugnani, MG | 1 |
| Cerletti, C; de Gaetano, G; Lauri, D | 1 |
| Brandon, RA; Bunce, IH; Curran, AC; Eadie, MJ; Emmett, JA | 1 |
| Ardlie, NG; Bell, LK; Garrett, JJ | 1 |
| Becker, BF; Gerlach, E; Kratzer, MA; Terres, W | 1 |
| Kirichuk, VF | 1 |
| Choi, SC; Duma, RJ; Evans, HJ; Fletcher, C; Pearson, C; Qureshi, GD | 1 |
| Castaldi, PA; Chong, BH | 1 |
| Corrigan, JJ; Fenster, PE; Ring, ME | 1 |
| Baca, M; Boschello, M; Dalla Volta, S; Marzari, A; Pengo, V; Schivazappa, L | 1 |
| Lefort, J; Lellouch-Tubiana, A; Pfister, A; Pirotzky, E; Vargaftig, BB | 1 |
| Basista, M; Grodzińska, L; Swies, J | 1 |
| Bertelé, V; Castagnoli, MN; Cerletti, C; de Gaetano, G; Rajtar, G | 1 |
| Andries, R; Bourgain, RH; Deby, C | 1 |
| Atkinson, PM; Bradlow, BA; Chetty, N | 1 |
| Gorczynska, E; James, M; Masiak, M; Wegrzynowicz, R | 1 |
| Carter, AJ; Heptinstall, S | 1 |
| Francis, CW; Marder, VJ; Peerschke, EI | 1 |
| Anwer, K | 1 |
| Bernini, W; De Caterina, R; Gazzetti, P; Giannessi, D | 1 |
| Hsu, MF; Hsu, TP; Teng, CM; Wang, JP | 1 |
| Dyerberg, J; Ring, T | 1 |
| Irino, O; Ohkubo, K; Saitoh, K | 1 |
| Kanbe, T; Kimura, Y; Tani, T; Watanabe, K | 1 |
| Hallam, TJ; Rink, TJ | 1 |
| Aggeler, PM; O'Reilly, RA; Sahud, MA | 1 |
| O'Brien, JR | 2 |
| Booyse, FM; Rafelson, ME | 1 |
| van Aken, WG; Vreeken, J | 1 |
| Bang, NU; Csiscko, BM; Heidenreich, RO; Schroeder, JE; Trygstad, W | 1 |
| Rieche, K; Wand, H | 1 |
| Wiedeman, MP | 1 |
| Dreyfus, MD; Jenkins, CS; Larrieu, MJ; Meyer, D | 1 |
| Ferguson, D; Lindsay, RM; McNicol, GP; Muir, WM; Prentice, CR | 1 |
| Kubisz, P | 1 |
| Ingerman, C; Kocsis, JJ; Silver, MJ; Smith, JB | 1 |
| Barbui, T; Battista, R; Dini, E | 1 |
| Barbui, T; Battista, R; Cartei, G; Cazzavillan, M; Chisesi, T; Dini, E | 1 |
| Sahud, MA | 2 |
| Mehlman, MA; Sporn, EM; Tobin, RB | 1 |
| Mircevová, L; Vopatová, M | 1 |
| De Gaetano, G; Donati, MB; Vermylen, J | 1 |
| Douglas, AS; Ogston, D | 1 |
| Salzman, EW; Weisenberger, H | 1 |
| Chesney, CM; Colman, RW; Harper, E | 1 |
| Deykin, D; Hardisty, RM; Howard, MA; Hutton, RA | 1 |
| Friedberg, NM; McPherson, VJ; Rifkin, PL; Zucker, MB | 1 |
| Reuter, H | 2 |
| Alburn, HE; Dougherty, JA; Fenichel, RL | 1 |
| Hawkins, RI | 1 |
| Brown, AK | 1 |
| Schmukler, M; Zieve, PD | 1 |
| Tschopp, B; Weiss, HJ | 1 |
| Kirby, RE; Lassman, HB; Novick, WJ | 1 |
| Emmanuel, IG; Malia, RG; Preston, FE; Winfield, DA | 1 |
| Sheppard, BL | 1 |
| Ulutin, ON | 1 |
| Adams, T; Goldberg, L; Schutz, L | 1 |
| George, JN | 1 |
| Connelly, PA; Eyring, EJ; Grosfeld, JL | 1 |
| Hussey, CV; Sanfelippo, MJ | 1 |
| Green, D; Rossi, EC | 1 |
| Hardisty, RM | 1 |
| Kasper, CK; Rapaport, SI | 1 |
| McBride, JA; Wallett, LH | 1 |
| Amorosi, EL | 1 |
| Borda, IT; Eldridge, C; Mills, DG; Philp, RB | 1 |
| Bruno, J; Nadell, J; Segre, EJ; Varady, J | 1 |
| Gagnatelli, G; Walsh, PN | 1 |
| de Gaetano, G; Poggi, A; Reyers-Degli Innocenti, I | 1 |
| Gielen, SY; Hornstra, G | 1 |
| Ramwell, P; Shio, H | 1 |
| Eika, C | 1 |
| Winckelmann, G | 1 |
| De Gaetano, G; Donati, MB; Palester-Chlebowczyk, M; Vermylen, J | 1 |
| Bousser, MG; Gautier, JC; Samama, M | 1 |
| Arfors, KE; Bygdeman, S; McKenzie, FN; Svensjö, E | 1 |
| Glusa, E | 1 |
| Bologna, E | 1 |
| Cortellaro, M; Pogliani, E; Polli, EE; Praga, C | 1 |
| Cepelák, V; Cepeláková, H; Nĕmecek, O; Roubal, Z | 1 |
| Ulutin, ON; Ulutin, SB; Yaramanci, TE | 1 |
| de Gaetano, G; Vermylen, J; Verstraete, M | 2 |
| Hilgard, P; Hohage, R; Minne, H; Schmitt, W; Ziegler, R | 1 |
| Cronberg, S | 1 |
| Day, HJ; Holmsen, H; Setkowsky, CA | 1 |
| Kolodjiez, A; Kricheff, II; Tschopp, TB; Zucker, MB | 1 |
| Rogers, J; Weiss, HJ | 2 |
| Britten, AF; Mielke, CH; Ramos, JC | 1 |
| Attar, S; Masaitis, C; McLaughlin, JS | 1 |
| Pogliani, EM; Praga, CA | 1 |
| Ames, RP; Weiss, HJ | 1 |
| Bousser, MG; Lecrubier, C | 1 |
| Levin, NW; Rossi, EC | 1 |
| Forbes, CD; Prentice, CR; Thomson, C | 1 |
| Kobayashi, I; Sano, T; Shimamoto, T; Yamazaki, H | 1 |
| de Gaetano, G; Vermylen, J | 1 |
| Aldridge, EG; Davis, JW; Yue, KT | 1 |
| Didisheim, P; Kobayashi, I | 1 |
| Margulies, EH; Wiedeman, MP | 1 |
| Freuler, F; Smith, GM | 1 |
| Borrelli, F; Caprino, L; Falchetti, R | 1 |
| Hofmann, HP; Kreiskott, H | 1 |
| Kuhn, DC; Weiss, HJ; Willis, AL | 1 |
| Alkjaersig, N; Etherington, M; Fletcher, A; Madgwick, T; O'Brien, JR; Tulevski, VG | 1 |
| Ardlie, NG; Han, P | 1 |
| Lüscher, EF | 1 |
| Caen, JP; Cronberg, S | 1 |
| Crowe, VG; Herrmann, RG; Lacefield, WB | 1 |
| Boneu, B; Fernet, P; Guiraud, B | 1 |
| Bowie, EJ; Didisheim, P; Neemeh, JA; Owen, CA; Thompson, JH | 1 |
| Ferguson, JH; Iatridis, PG; Rodman, NF; Sarji, KE | 1 |
| Colwell, JA; Cruz, S; Dobbie, JG; Kwaan, HC; Suwanwela, N | 1 |
| Crowe, VG; Frank, JD; Herrmann, RG; Lacefield, WB; Marlett, DL; Marshall, WS | 1 |
| Arfors, KE; Bergqvist, D; Bygdeman, S; McKenzie, FN; Svensjö, E | 1 |
| Hamp, JA; Meester, WD; Schut, GE; Sekhar, NC | 1 |
| Auvergnat, A; Biermé, R; Boneu, A; Boneu, B; Corberand, J; Guiraud, B; Monnier, J; Pris, J | 1 |
| Casteels-van Daele, M; Claes, JH; De Gaetano, G; Eeckels, R | 1 |
| Bounameaux, Y | 1 |
| Doery, JC; Hirsh, J | 1 |
| Zbinden, G | 1 |
| Begent, NA; Born, GV | 1 |
| Larrieu, MJ | 1 |
| Nakasawa, S; Yamada, K; Yamada, Z | 1 |
| David, JL | 1 |
| Cortellaro, M; Praga, C | 1 |
| Begent, NA; Born, GV; Görög, P | 1 |
| D'Angelo, A; Galli, G; Mannucci, PM; Pareti, FI; Sautebin, L; Smith, JB | 1 |
| Rao, GH; Reddy, RK; White, JG | 1 |
| Benveniste, J; Hadji, L; Mencia-Huerta, JM | 1 |
| Kelton, JG | 1 |
| Born, GV; Shafi, S; Thorngren, M | 1 |
| Clagett, GP; Hufnagel, H; Russo, M | 1 |
| Hladovec, J | 1 |
| Cros, G; Lalaurie, M; Mary, A; Modat, G | 1 |
| Cofrancesco, E; Colombi, M; Cristoforetti, G; Pogliani, EM | 1 |
| Thaulow, E | 1 |
| Birgens, HS; Hansen, MS | 1 |
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| Grześk, G; Kasprzak, M; Kubica, A; Kubica, J; Obońska, K; Ostrowska, M; Stolarek, W; Wiciński, M | 1 |
| Barinov, EF; Mamedaliyeva, S; Tverdokhleb, TA | 1 |
| Barbieri, L; Bellomo, G; De Luca, G; Marino, P; Nardin, M; Pergolini, P; Rolla, R; Schaffer, A; Suryapranata, H; Verdoia, M | 2 |
| Bijak, M; Boryczka, K; Golanski, J; Golanski, R; Kaczmarski, J; Kuliczkowski, W; Watala, C | 1 |
| Dunne, E; Egan, K; Foley, D; Kenny, D; McFadden, S | 1 |
| Huang, W; Li, J; Liu, H; Wang, J; Wang, Y; Xie, D; Zhang, Y; Zhu, P; Zuo, J | 1 |
| Frelinger, AL; Gremmel, T; Michelson, AD; Przyklenk, K; Undyala, VV; Wider, J; Wright, GE; Yanachkov, IB; Yanachkova, MI | 1 |
| Eichelberger, B; Gremmel, T; Kopp, CW; Koppensteiner, R; Panzer, S; Xhelili, E | 1 |
| Anderson, MS; Chappell, DL; Gheyas, F; Gilmartin, JH; Horrow, JC; Kraft, WK; Nagalla, S; Naik, UP; Walker, BM; Wrishko, RE; Zhang, S | 1 |
| Gao, RL; He, C; Liu, R; Ma, YL; Meng, XM; Song, L; Song, Y; Tang, XF; Wang, M; Xu, JJ; Yao, Y; Yuan, JQ; Zhang, JH | 1 |
| Backman, JD; Donnelly, P; Drolet, M; Horenstein, RB; Lewis, JP; Mitchell, BD; Morrisey, M; Newcomer, S; O'Connell, JR; Pavlovich, MA; Shaub, S; Tanner, K; Yerges-Armstrong, LM | 1 |
| Bangalore, R; DePalma, L; Hase, T; Maluso, P; Sarani, B; Sirajuddin, S | 1 |
| Biolik, G; Kokot, M; Pawlicki, K; Święszek, A; Sznapka, M; Ziaja, D; Ziaja, K | 1 |
| Bezerra, LS; Castro-Gomez, RJH; Cavalcante, HC; Magnani, M; Medeiros, IA; Silva, TAFD; Veras, RC; Vieira, RLP | 1 |
| Almquist, J; Gennemark, P; Goodman, J; Janefeldt, A; Johansson, KJ; Maqbool, S; Nylander, S; Pehrsson, S; Sanchez, J; Sandinge, AS | 1 |
| Chin, CM; Dos Santos, JL; Dutra, LA; Guanaes, JFO; Johmann, N; Lopes Pires, ME; Marcondes, S | 1 |
| Cao, Y; Dong, K; Liu, L; Rao, Z; Wang, A; Wang, F; Wang, Y; Zhao, X; Zheng, H | 1 |
| Gremmel, T; Kopp, CW; Koppensteiner, R; Lang, IM; Lee, S; Panzer, S; Pultar, J; Wadowski, PP; Weikert, C | 1 |
| Chen, J; Gao, LJ; Gao, RL; Gao, Z; Qiao, SB; Tang, XF; Xu, B; Xu, JJ; Yang, YJ; Yuan, JQ; Zhang, Y; Zhu, P | 1 |
| Al Mamary, A; Campello, E; Dalla Valle, F; Maggiolo, S; Napodano, M; Piazza, D; Simioni, P; Spiezia, L | 1 |
| Brunner, S; Hamm, W; Lackermair, K; Mehr, M; Rizas, K | 1 |
| Choi, SY; Kim, MH | 1 |
| Chernousova, LA; Denisova, TP; Dolotovskaya, PV; Furman, NV; Malinova, LI | 1 |
| Aradi, D; Dézsi, DA; Freynhofer, MK; Geisler, T; Gross, L; Haller, PM; Hein-Rothweiler, R; Huber, K; Huczek, Z; Massberg, S; Orban, M; Sibbing, D; Toth-Gayor, GG; Trenk, D | 1 |
| Alemanno, L; Angiolillo, DJ; Ceccacci, A; Frati, L; Guarino, ML; Guerriero, R; Mancone, M; Massimi, I; Pulcinelli, FM | 1 |
| Eikelboom, JW; Fan, Y; Li, C; Li, J; Mei, L; Niles, K; Wang, F; Xu, K; Yang, L; Zhang, J; Zhang, S; Zhu, H; Zou, F | 1 |
| Li, RHL; Nguyen, N; Tablin, F | 1 |
| Ge, JB; Qian, JY; Wang, QB; Wu, HY; Zhang, C; Zhao, X | 1 |
| Bryant, SC; Jaffe, AS; Karon, BS; Katzman, BM; Scott, RJ; Wockenfus, AM | 1 |
| Gager, GM; Hengstenberg, C; Jilma, B; Kolesnik, E; Lang, IM; Prüller, F; Siller-Matula, JM; Toma, A; von Lewinski, D; Wallner, M; Winter, MP | 1 |
| Guo, L; Huang, Q; Shi, X; Wang, G; Yang, Y; Yuan, D; Yuan, Y; Zhang, H; Zhao, Y | 1 |
| Bagger, H; Hansson, M; Kander, T; Schött, U | 1 |
| Bokemeyer, C; Fiehler, J; Frölich, AM; Haddad, M; Holst, B; Holstein, K; Janjetovic, S; Langer, F; Renné, T; Rolling, CC; Rolling, T; Tomada, J; Voigtländer, M | 1 |
| Chen, J; Li, X; Lv, Q; Wang, Z; Wu, H; Xue, Y | 1 |
| Li, Q; Tu, C; Ye, Y; Zeng, Y; Zhao, X | 1 |
| Eichinger, S; Kaider, A; Kollars, M; Kyrle, PA; Siller-Matula, JM; Steinbrecher, O; Traby, L; Wolzt, M | 1 |
| Armstrong, PCJ; Chan, MV; Chen, MH; de Melendez, CW; Garelnabi, M; Grech, J; Johnson, AD; Lachapelle, A; Nkambule, BB; Ochin, C; Schneider, Z; Thibord, F; Tucker, KL; Warner, TD | 1 |
| Friebel, J; Hassanein, A; Jakobs, K; Landmesser, U; Puccini, M; Rauch, C; Rauch, U | 1 |
| Li, X; Lv, Q; Wang, Z; Xia, L; Yao, Y; Ye, Y; Zou, Y | 1 |
| Han, X; He, M; Kong, Y; Li, Y; Liu, G; Ren, J; Shi, J; Yan, W; Zhang, Y; Zhao, Z | 1 |
| Fiołka, M; Poniedziałek, B; Rosińska, J; Rzymski, P | 1 |
| Costa, TGR; Franken, M; Guerra, JCC; Katz, M; Lemos Neto, PA; Pesaro, AEP | 1 |
| Biocina, B; Gasparovic, H; Kalamar, V; Konosic, S; Krzelj, K; Mihaljevic, MZ; Milosevic, M; Petricevic, M; Starcevic, Z; Svetina, L; Urlic, M | 1 |
| Barrett, TJ; Berger, JS; Heffron, SP; Voora, D; Windheim, J | 1 |
| Hu, X; Liu, C; Zhang, M; Zhang, W | 1 |
| Baucom, MR; England, L; Goodman, MD; Pritts, TA; Schuster, R; Turner, K; Wallen, TE; Youngs, J | 1 |
| Barrs, VR; Griebsch, C; Hall, E | 1 |
| Collins, DR; Coughlan, T; Cox, D; Egan, B; Lim, ST; Lim, SY; McCabe, DJH; McCarthy, AJ; Murphy, SJX; Murphy, SM; O'Neill, D; Smith, DR; Tierney, S | 1 |
| Angiolillo, DJ; Been, L; Franchi, F; Galli, M; Rollini, F; Zenni, MM | 1 |
| Bor, WL; Breet, NC; Hackeng, CM; Kelder, JC; Kropman, RHJ; Noordzij, PG; Ten Berg, JM; Vernooij, LM; Zheng, KL | 1 |
| Alasadi, Y; Asgar, JA; Bliden, KP; Chaudhary, R; Duhan, S; Gill, H; Gurbel, PA; Kundan, P; Sharma, T; Singh, A; Tantry, US | 1 |
| Blaha, V; Carazo, A; Hrubša, M; Javorská, L; Karlíčková, J; Konečný, L; Krčmová, LK; Matoušová, K; Mladěnka, P; Musil, F; Paclíková, M; Parvin, MS; Skořepa, P; Šmahelová, A | 1 |
| Bender, L; Dorn, C; Franko, M; Franz, C; May, R; Minkenberg, J; Nikoubashman, O; Ridwan, H; Sichtermann, T; Stockero, A; Wiesmann, M | 1 |
| Cheung, SS; Hellsten, Y; Lundberg Slingsby, MH; Nørregaard, LB; Wickham, KA | 1 |
| Alves Dos Santos, M; Bittar Brito Arantes, F; Dalçóquio, TF; de Nazare Nunes Alves, MJ; Ferreira-Santos, L; Franci, A; Furtado, RHM; Gehlen Ferrari, A; Genestreti Rizzo, PR; Moreira Baracioli, L; Negrão, CE; Nicolau, JC; Pinto Brandão Rondon, MU; Salsoso, R; Silva Alves, L | 1 |
| Fuga, M; Hasegawa, Y; Ishibashi, T; Murayama, Y; Tachi, R; Tanaka, T; Teshigawara, A; Tomoto, K; Wachi, R | 1 |
40 review(s) available for aspirin and adenosine diphosphate
| Article | Year |
|---|---|
[Blood platelets and cardiovascular diseases. IV. Platelet-inhibiting drugs and antithrombotic agents].
Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Analgesics; Anti-Inflammatory Agents; Arteriosclerosis; Aspirin; Blood Coagulation; Blood Platelets; Cardiovascular Diseases; Dipyridamole; Dose-Response Relationship, Drug; Fibrinolytic Agents; Humans; In Vitro Techniques; Indomethacin; Oxyphenbutazone; Phenylbutazone; Platelet Adhesiveness; Platelet Aggregation; Sulfinpyrazone; Thromboembolism; Time Factors | 1976 |
Prostaglandins and platelet function.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Calcium; Centrifugation; Chromatography, Gel; Colchicine; Collagen; Cyclic AMP; Epinephrine; Humans; Models, Biological; Peroxides; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins; Protein Kinases; Thrombin | 1976 |
Clinical pharmacology of platelets.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation; Blood Platelets; Cell Membrane; Clofibrate; Cyproheptadine; Dipyridamole; Drug Therapy, Combination; Furosemide; Halofenate; Heparin; Humans; Hydrocortisone; Hydroxychloroquine; Methylprednisolone; Penicillin G; Platelet Aggregation; Propranolol; Prostaglandins; Sulfinpyrazone; Vitamin E | 1977 |
Pharmacology of platelet-suppressive agents.
Topics: Adenosine Diphosphate; Anti-Inflammatory Agents; Arachidonic Acids; Aspirin; Blood Platelets; Calcium; Cell Membrane; Clofibrate; Dipyridamole; Epoprostenol; Halofenate; Heparin; Humans; Imidazoles; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins E; Prostaglandins, Synthetic | 1979 |
Vitamin E and platelets: cooperative interactions with nitroblue tetrazolium on inhibition of adhesion, aggregation and secretion.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Collagen; Epinephrine; Humans; Indomethacin; Microscopy, Electron; Nitroblue Tetrazolium; Platelet Adhesiveness; Platelet Aggregation; Tetrazolium Salts; Thrombin; Vitamin E | 1979 |
Prostaglandins and precursors in platelet function.
Topics: Adenosine Diphosphate; Arachidonic Acids; Aspirin; Biotransformation; Blood Platelets; Humans; In Vitro Techniques; Indomethacin; Malondialdehyde; Peroxides; Platelet Aggregation; Prostaglandins; Serotonin; Species Specificity; Thrombin | 1975 |
The pharmacology of platelet inhibition.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Blood Platelets; Citric Acid Cycle; Collagen; Cyclic AMP; Dipyridamole; Hexosephosphates; Histamine H1 Antagonists; Microscopy, Electron; Platelet Adhesiveness; Prostaglandins; Serotonin; Xanthines | 1972 |
Platelet disorders: a review of disturbances in adhesion, aggregation, and release reaction.
Topics: Adenosine Diphosphate; Afibrinogenemia; Anemia; Aspirin; Blood Platelet Disorders; Connective Tissue; Down Syndrome; Female; Glycogen Storage Disease; Humans; Liver Cirrhosis; Male; Platelet Adhesiveness; Polycythemia Vera; Uremia; Waldenstrom Macroglobulinemia; Wiskott-Aldrich Syndrome | 1972 |
Role of cyclic AMP in platelet function.
Topics: Adenosine; Adenosine Diphosphate; Aspirin; Biological Transport; Blood Platelets; Butyrates; Carbon Isotopes; Cell Aggregation; Collagen; Cyclic AMP; Epinephrine; Kaolin; Kinetics; Models, Biological; Phentolamine; Platelet Adhesiveness; Propranolol; Protein Kinases; Time Factors; Tritium | 1972 |
[Aggregation inhibitors. The inhibition of platelet function by means of chemical substances].
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Aspirin; Blood Proteins; Calcium; Collagen; Dipyridamole; Epinephrine; Humans; Molecular Conformation; Phenothiazines; Phosphoric Diester Hydrolases; Platelet Adhesiveness; Platelet Aggregation; Sympatholytics; Thrombin; Thrombosis | 1973 |
The importance of platelet function tests in toxicological screening using laboratory animals.
Topics: Adenosine Diphosphate; Animals; Animals, Laboratory; Aspirin; Blood Cell Count; Blood Coagulation; Blood Coagulation Factors; Blood Platelets; Clot Retraction; Dogs; Electrophoresis; Haplorhini; Hemostasis; Histamine H1 Antagonists; Humans; Macaca; Norepinephrine; Platelet Adhesiveness; Rabbits; Rats; Smoking; Thrombelastography | 1972 |
Disorders of platelet function.
Topics: Adenosine Diphosphate; Adolescent; Aspirin; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets; Clot Retraction; Collagen; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Adhesiveness; Thrombocythemia, Essential; Tourniquets; Wiskott-Aldrich Syndrome | 1972 |
Haemostatic functions of platelets and their disorders.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Afibrinogenemia; Aspirin; Blood Coagulation Disorders; Blood Platelet Disorders; Blood Platelets; Carbon Isotopes; Hemostasis; Humans; Microscopy, Electron; Phosphates; Phosphorus Isotopes; Platelet Adhesiveness | 1972 |
The clinical relevance of platelet function tests.
Topics: Adenosine Diphosphate; Aspirin; Blood Cell Count; Blood Coagulation Factors; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets; Hemorrhage; Humans; Phospholipids; Platelet Adhesiveness; Purpura, Thrombocytopenic; Thrombocytopenia; von Willebrand Diseases | 1972 |
Bleeding disorders due to abnormal platelet function.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets; Clot Retraction; Epinephrine; Hemostasis; Humans; Liver Diseases; Myeloproliferative Disorders; Platelet Adhesiveness; Prostaglandins; Uremia; von Willebrand Diseases | 1973 |
Acute manifestations of platelet dysfunction.
Topics: Acute Disease; Adenosine Diphosphate; Aspirin; Blood Coagulation Factors; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets; Clot Retraction; Disseminated Intravascular Coagulation; Epinephrine; Hemostasis; Humans; Liver Diseases; Phospholipids; Platelet Adhesiveness; Purpura, Thrombocytopenic; Thrombocytosis; Time Factors; Uremia; von Willebrand Diseases | 1973 |
[Blood platelet diseases].
Topics: Adenosine Diphosphate; Afibrinogenemia; Aspirin; Blood Platelet Disorders; Blood Platelets; Diagnosis, Differential; Ehlers-Danlos Syndrome; Eosinophilia; Hematologic Diseases; Humans; Leukocytes; Liver Cirrhosis; Lupus Erythematosus, Systemic; Neutrophils; Platelet Adhesiveness; Purpura, Thrombocytopenic; Waldenstrom Macroglobulinemia | 1973 |
Current concepts on normal and modified platelet aggregation.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation; Blood Platelets; Humans; Platelet Adhesiveness; Prostaglandins; Thrombin; Venoms | 1971 |
Antiplatelet agents: rationale and results.
Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Animals; Arachidonic Acids; Aspirin; Blood Platelets; Blood Vessel Prosthesis; Cerebrovascular Disorders; Collagen; Coronary Disease; Dipyridamole; Female; Heart Valve Prosthesis; Hemostasis; Humans; Intracranial Embolism and Thrombosis; Male; Myocardial Infarction; Platelet Adhesiveness; Platelet Aggregation; Sex Factors; Sulfinpyrazone; Thrombosis | 1983 |
[Platelet suppressive drugs (author's transl)].
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Cyclic AMP; Epinephrine; Humans; Intracranial Embolism and Thrombosis; Platelet Aggregation; Prostaglandins E | 1981 |
Thromboxane A2, prostacyclin and aspirin: effects on vascular tone and platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Vessels; Cats; Coronary Vessels; Epoprostenol; Guinea Pigs; Humans; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandins; Prostaglandins E; Prostaglandins F; Rabbits; Thromboxane A2; Thromboxanes | 1980 |
Antiplatelet therapy in coronary heart disease.
Topics: Adenosine Diphosphate; Adult; Aged; Angina Pectoris; Aspirin; Blood Platelets; Cerebrovascular Disorders; Coronary Disease; Epinephrine; Epoprostenol; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Adhesiveness; Platelet Aggregation; Propranolol; Thromboxane A2 | 1982 |
Antiplatelet drugs. A comparative review.
Topics: Adenosine Diphosphate; Animals; Aspirin; Base Sequence; Blood Platelets; Consensus Sequence; Humans; Molecular Sequence Data; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Thrombin; Thrombosis; Thromboxanes | 1995 |
Thrombosis and inflammation as multicellular processes: significance of cell-cell interactions.
Topics: Adenosine Diphosphate; Apyrase; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Eicosanoids; Endothelium, Vascular; HSP70 Heat-Shock Proteins; Humans; Inflammation; Nitric Oxide; Platelet Activation; Thrombosis | 1995 |
Clinical pharmacology of the adenosine diphosphate (ADP) receptor antagonist, clopidogrel.
Topics: Adenosine Diphosphate; Animals; Arteriosclerosis; Aspirin; Clopidogrel; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Signal Transduction; Thrombosis; Ticlopidine | 1998 |
Ticlopidine and clopidogrel.
Topics: Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Angina, Unstable; Aspirin; Bone Marrow Diseases; Carbamazepine; Cardiovascular Diseases; Clopidogrel; Combined Modality Therapy; Coronary Disease; Drug Interactions; Hemorrhage; Humans; Myocardial Infarction; Peripheral Vascular Diseases; Phenytoin; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Safety; Stents; Theophylline; Thrombolytic Therapy; Ticlopidine | 1999 |
Unstable angina and non-ST-segment elevation myocardial infarction: perspectives on combination therapy.
Topics: Adenosine Diphosphate; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Drug Therapy, Combination; Heparin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex | 2001 |
Scientific and therapeutic advances in antiplatelet therapy.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Cardiovascular Diseases; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Single Nucleotide | 2003 |
Heterologous cell-cell interactions: thromboregulation, cerebroprotection and cardioprotection by CD39 (NTPDase-1).
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Antigens, CD; Apyrase; Aspirin; Cell Communication; Endothelial Cells; Hemostasis; Humans; Thrombosis | 2003 |
Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis.
Topics: Adenosine Diphosphate; Animals; Arteriosclerosis; Aspirin; Clinical Trials as Topic; Clopidogrel; Cohort Studies; Double-Blind Method; Drug Resistance; Fibrinolytic Agents; Forecasting; Humans; Membrane Proteins; Meta-Analysis as Topic; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Pyridines; Randomized Controlled Trials as Topic; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thrombophilia; Thrombosis; Ticlopidine | 2005 |
Pharmacology of CS-747 (prasugrel, LY640315), a novel, potent antiplatelet agent with in vivo P2Y12 receptor antagonist activity.
Topics: Adenosine Diphosphate; Adult; Animals; Aspirin; Biotransformation; Clinical Trials, Phase I as Topic; Clopidogrel; Collagen; Drug Evaluation, Preclinical; Drug Synergism; Fibrinolytic Agents; Hemostasis; Humans; Male; Membrane Proteins; Molecular Structure; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Thrombin; Thrombosis; Ticlopidine | 2005 |
Role of CD39 (NTPDase-1) in thromboregulation, cerebroprotection, and cardioprotection.
Topics: Adenosine Diphosphate; Animals; Antigens, CD; Apyrase; Aspirin; Blood Vessels; Cardiotonic Agents; Cells, Cultured; Cerebral Infarction; Coronary Disease; Drug Evaluation, Preclinical; Endothelial Cells; Endothelium, Vascular; Fibrinolytic Agents; Humans; Mice; Mice, Knockout; Mutagenesis, Site-Directed; Neuroprotective Agents; Platelet Aggregation; Platelet Aggregation Inhibitors; Recombinant Proteins; Structure-Activity Relationship; Synaptosomes; Thrombosis | 2005 |
Can platelet function tests predict the clinical efficacy of aspirin?
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Clinical Trials as Topic; Drug Resistance; Flow Cytometry; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Thromboxane B2; Time Factors | 2005 |
The influence of new antithrombotic drugs on regional anesthesia.
Topics: Adenosine Diphosphate; Anesthesia, Conduction; Anesthesia, Epidural; Aspirin; Cardiac Surgical Procedures; Clinical Trials as Topic; Drug Administration Schedule; Female; Fibrinolytic Agents; Fondaparinux; Hematoma, Epidural, Spinal; Heparin, Low-Molecular-Weight; Humans; Nerve Block; Pain Measurement; Pain, Postoperative; Plant Preparations; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polysaccharides; Practice Guidelines as Topic; Prevalence; Risk Assessment; Risk Factors | 2006 |
Management of antiplatelet therapy for minimization of bleeding risk before cardiac surgery.
Topics: Adenosine Diphosphate; Aspirin; Blood Loss, Surgical; Coronary Artery Bypass; Coronary Thrombosis; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex | 2006 |
Prasugrel.
Topics: Adenosine Diphosphate; Animals; Aspirin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase III as Topic; Clopidogrel; Collagen; Coronary Disease; Drug Evaluation, Preclinical; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Drugs, Investigational; Humans; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2006 |
Variable platelet response to aspirin and clopidogrel in atherothrombotic disease.
Topics: Adenosine Diphosphate; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Biomarkers; Biotransformation; Blood Coagulation Tests; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Interactions; Drug Resistance; Hemorrhage; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thrombosis; Thromboxane A2; Thromboxane B2; Ticlopidine; Treatment Failure | 2007 |
[Significance of platelet function tests].
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelet Disorders; Clopidogrel; Collagen; Hemorrhagic Disorders; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prognosis; Ristocetin; Ticlopidine | 2010 |
Importance of measurement of platelet reactivity to ADP in patients with coronary artery disease: an historical account.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Coronary Artery Disease; Drug Therapy, Combination; Humans; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents | 2013 |
Sex-Related Differences in Platelet Aggregation: A Literature Review Supplemented with Local Data from a Group of Generally Healthy Individuals.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Female; Humans; Lactones; Male; Platelet Aggregation; Platelet Aggregation Inhibitors | 2023 |
115 trial(s) available for aspirin and adenosine diphosphate
| Article | Year |
|---|---|
The effects of four commonly used drugs on platelet function.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Coagulation; Blood Platelets; Diphenhydramine; Guaifenesin; Humans; In Vitro Techniques; Platelet Aggregation; Pyridines; Triprolidine | 1976 |
The effect of platelet function inhibitors on experimental venous thrombosis formation in rabbits.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Clinical Trials as Topic; Collagen; Dipyridamole; Female; Male; Platelet Adhesiveness; Platelet Aggregation; Rabbits; Sulfinpyrazone; Thrombophlebitis; Tromethamine | 1975 |
"Car. factor" deficiency revisited.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aspirin; Black People; Blood Coagulation; Blood Coagulation Disorders; Blood Platelets; Blood Protein Electrophoresis; Child; Child, Preschool; Clinical Trials as Topic; Collagen; Female; Humans; Male; Norepinephrine; Platelet Adhesiveness; Platelet Aggregation; Thrombin; Thromboplastin; White People | 1975 |
Synergic effect of cicaprost-clathrate and low-dose acetylsalicylic acid on platelet aggregation in man.
Topics: Adenosine Diphosphate; Adult; Aspirin; Collagen; Drug Combinations; Drug Synergism; Epoprostenol; Humans; Platelet Aggregation; Single-Blind Method | 1992 |
Effects of aspirin, dipyridamole, nifedipine and cavinton which act on platelet aggregation induced by different aggregating agents alone and in combination.
Topics: Adenosine Diphosphate; Arteriosclerosis; Aspirin; Collagen; Dipyridamole; Double-Blind Method; Epinephrine; Humans; In Vitro Techniques; Middle Aged; Nifedipine; Platelet Aggregation; Platelet Aggregation Inhibitors; Vinca Alkaloids | 1992 |
Dose-dependent aspirin hydrolysis and platelet aggregation in patients with atherosclerosis.
Topics: Adenosine Diphosphate; Arteriosclerosis; Aspirin; Collagen; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydrolysis; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors | 1992 |
Effect of aspirin infusions on platelet function in humans.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Time Factors | 1990 |
Aspirin at very ultra low dosage in healthy volunteers: effects on bleeding time, platelet aggregation and coagulation.
Topics: Adenosine Diphosphate; Adult; Aspirin; Bleeding Time; Blood Coagulation; Collagen; Double-Blind Method; Humans; Male; Platelet Aggregation; Random Allocation | 1990 |
Platelet aggregation in human whole blood after chronic administration of aspirin.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Cells; Cell Separation; Collagen; Dose-Response Relationship, Drug; Epinephrine; Humans; In Vitro Techniques; Male; Platelet Aggregation; Research Design | 1987 |
Peripheral venous plasma aspirin concentrations and platelet aggregation inhibition produced by enteric-coated aspirin formulations.
Topics: Adenosine Diphosphate; Administration, Oral; Adult; Arachidonic Acids; Aspirin; Collagen; Female; Humans; Male; Platelet Aggregation; Tablets, Enteric-Coated; Time Factors | 1986 |
Bleeding times and platelet aggregation after analgesics in hemophilia.
Topics: Acetaminophen; Adenosine Diphosphate; Adolescent; Adult; Analgesics; Aspirin; Blood Coagulation Factors; Blood Coagulation Tests; Clinical Trials as Topic; Collagen; Dextropropoxyphene; Epinephrine; Hemophilia A; Humans; Male; Placebos; Platelet Adhesiveness; Sodium Chloride | 1972 |
Effects of in vitro aspirin on blood platelets of gastrointestinal bleeders.
Topics: Adenosine Diphosphate; Adult; Aged; Aspirin; Blood Platelets; Clinical Trials as Topic; Collagen; Densitometry; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Hematocrit; Hemoglobins; Humans; Male; Middle Aged; Platelet Adhesiveness | 1974 |
Effect of naproxen and of aspirin on bleeding time and platelet aggregation.
Topics: Adenosine Diphosphate; Adult; Analysis of Variance; Aspirin; Blood Cell Count; Blood Coagulation; Clinical Trials as Topic; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Naphthalenes; Occult Blood; Placebos; Platelet Adhesiveness; Propionates; Prothrombin Time; Salicylates; Time Factors | 1974 |
Platelet function studies before and after operation and the effect of postoperative thrombosis.
Topics: Adenosine Diphosphate; Adult; Aged; Aspirin; Blood Cell Count; Blood Platelets; Chromatography; Collagen; Epinephrine; Female; Fibrinogen; Humans; Iodine Radioisotopes; Leg; Male; Middle Aged; Neoplasms; Placebos; Platelet Adhesiveness; Postoperative Complications; Radionuclide Imaging; Surgical Procedures, Operative; Thrombin; Thrombosis | 1974 |
Hemostatic function of aspirin-treated platelets vulnerable to cardiopulmonary bypass. Altered shear-induced pathway.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Coagulation Tests; Blood Loss, Surgical; Blood Platelets; Cardiopulmonary Bypass; Coronary Artery Bypass; Double-Blind Method; Hemostasis; Humans; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Thromboxane B2 | 1995 |
Compliance with antiplatelet therapy in patients with ischemic cerebrovascular disease. Assessment by platelet aggregation testing.
Topics: Adenosine Diphosphate; Aged; Aspirin; Cerebral Infarction; Collagen; Drug Monitoring; Female; Follow-Up Studies; Humans; Inpatients; Intracranial Embolism and Thrombosis; Ischemic Attack, Transient; Male; Outpatients; Patient Compliance; Platelet Aggregation; Ticlopidine | 1994 |
Effect of diltiazem and low-dose aspirin on platelet aggregation and ATP release induced by paired agonists.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Arachidonic Acid; Aspirin; Bleeding Time; Blood Platelets; Diltiazem; Drug Synergism; Epinephrine; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors | 1993 |
Platelet aggregation in patients with atrial fibrillation taking aspirin or warfarin.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Atrial Fibrillation; Cerebrovascular Disorders; Collagen; Epinephrine; Humans; In Vitro Techniques; Kinetics; Platelet Aggregation; Warfarin | 1993 |
The evolution of platelet aggregability in patients undergoing catheter ablation for supraventricular tachycardia with radiofrequency energy: the role of antiplatelet therapy.
Topics: Adenosine Diphosphate; Adult; Aorta; Aspirin; Catheter Ablation; Collagen; Electric Impedance; Female; Follow-Up Studies; Humans; Male; Monitoring, Intraoperative; Placebos; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Care; Pulmonary Artery; Tachycardia, Supraventricular; Temperature; Thromboxane B2; Time Factors | 1995 |
Anti-platelet effects of 100 mg alternate day oral aspirin: a randomized, double-blind, placebo-controlled trial of regular and enteric coated formulations in men and women.
Topics: Adenosine Diphosphate; Administration, Oral; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cardiovascular Diseases; Double-Blind Method; Drug Administration Schedule; Epinephrine; Epoprostenol; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Radioimmunoassay; Risk Factors; Thromboxanes | 1996 |
Hemostaseologic and hematologic parameters with aspirin and ticlopidine treatment in patients with cerebrovascular disease: a cross-over study.
Topics: Adenosine Diphosphate; Aged; Aspirin; Cerebrovascular Disorders; Collagen; Cross-Over Studies; Epinephrine; Female; Fibrinogen; Hemostasis; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; Ticlopidine | 1996 |
Platelet responses to several agonists and combinations of agonists in whole blood: a placebo controlled comparison of the effects of a once daily dose of plain aspirin 300 mg, plain aspirin 75 mg and enteric coated aspirin 300 mg, in man.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Coagulants; Collagen; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Male; Placebos; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Ristocetin; Streptokinase; Tablets, Enteric-Coated | 1997 |
The effect of antiplatelet drugs, heparin, and preanalytical variables on platelet function detected by the platelet function analyzer (PFA-100).
Topics: Abciximab; Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Blood Platelets; Blood Specimen Collection; Calcium; Chelating Agents; Computers; Coronary Disease; Dose-Response Relationship, Drug; Equipment Design; Heparin; Humans; Immunoglobulin Fab Fragments; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 1999 |
Monitoring of aspirin (ASA) pharmacodynamics with the platelet function analyzer PFA-100.
Topics: Adenosine Diphosphate; Adult; Antigens; Antigens, CD; Aspirin; Blood Coagulation Tests; Blood Platelets; Collagen; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Epinephrine; Female; Fibrinolytic Agents; Flow Cytometry; Genotype; Homozygote; Humans; Integrin alpha2; Longitudinal Studies; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Point Mutation; Prospective Studies; Thromboxane B2; Time Factors; von Willebrand Factor | 2000 |
Pharmacokinetics and pharmacodynamics of sibrafiban, an orally administered GP IIb/IIIa antagonist, following coadministration of aspirin and heparin.
Topics: Adenosine Diphosphate; Administration, Oral; Adult; Anticoagulants; Area Under Curve; Aspirin; Bleeding Time; Cross-Over Studies; Drug Interactions; Female; Heparin; Humans; Male; Middle Aged; Oximes; Partial Thromboplastin Time; Peptide Fragments; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs; Prothrombin Time; Receptors, Thrombin | 2000 |
Antiplatelet effects of clopidogrel compared with aspirin after myocardial infarction: enhanced inhibitory effects of combination therapy.
Topics: Adenosine Diphosphate; Adult; Aged; Antigens, CD; Aspirin; Blood; Clopidogrel; Collagen; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dual Specificity Phosphatase 2; Humans; Middle Aged; Myocardial Infarction; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prospective Studies; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Tetraspanin 30; Ticlopidine | 2000 |
Acute antithrombotic effect of a front-loaded regimen of clopidogrel in patients with atherosclerosis on aspirin.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Drug Therapy, Combination; Fibrinogen; Fibrinolytic Agents; Humans; Perfusion; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2000 |
Clinical utility of the platelet function analyzer (PFA-100) for the assessment of the platelet status in patients with congestive heart failure (EPCOT trial).
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Coagulation; Collagen; Female; Heart Failure; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Point-of-Care Systems; Regression Analysis; Severity of Illness Index; Stress, Mechanical | 2001 |
Effect of salicis cortex extract on human platelet aggregation.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Collagen; Double-Blind Method; Female; Furosemide; Humans; Low Back Pain; Male; Medicine, Traditional; Middle Aged; Phytotherapy; Plant Extracts; Plant Stems; Plants, Medicinal; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Portugal | 2001 |
Effects of combined therapy with clopidogrel and acetylsalicylic acid on platelet glycoprotein expression and aggregation.
Topics: Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Coronary Disease; Drug Synergism; Drug Therapy, Combination; Dual Specificity Phosphatase 2; Female; Humans; Male; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Ticlopidine | 2002 |
Comparison of antiplatelet effect of loading dose of clopidogrel versus abciximab during coronary intervention.
Topics: Abciximab; Adenosine Diphosphate; Aged; Aged, 80 and over; Angina Pectoris; Antibodies, Monoclonal; Aspirin; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Ticlopidine; Treatment Outcome | 2002 |
Celecoxib does not affect the antiplatelet activity of aspirin in healthy volunteers.
Topics: Adenosine Diphosphate; Adolescent; Adult; Arachidonic Acid; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Female; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thromboxane B2 | 2002 |
Evaluation of a Platelet Function Analyser (PFA-100) in patients with a bleeding tendency.
Topics: Adenosine Diphosphate; Adrenergic Agonists; Adult; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Drug Administration Schedule; Epinephrine; Female; Hemorrhagic Disorders; Hemostasis; Humans; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reference Values; Sensitivity and Specificity; von Willebrand Diseases | 2002 |
Rapid platelet inhibition after a single capsule of Aggrenox: challenging a conventional full-dose aspirin antiplatelet advantage?
Topics: Adenosine Diphosphate; Adult; Aspirin; Aspirin, Dipyridamole Drug Combination; Blood Platelets; Capsules; Dipyridamole; Dose-Response Relationship, Drug; Drug Combinations; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Stroke; Time Factors | 2003 |
The antiplatelet aggregation effects of aspirin suppositories.
Topics: Adenosine Diphosphate; Adult; Aspirin; Collagen; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Sex Characteristics; Suppositories | 2003 |
Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity.
Topics: Adenosine Diphosphate; Aged; Aspirin; Biomarkers; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Resistance; Female; Flow Cytometry; Genetic Variation; Humans; Male; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine | 2003 |
Effect of different aspirin doses on platelet aggregation in patients with stable coronary artery disease.
Topics: Adenosine Diphosphate; Adult; Aged; Aspirin; Coronary Disease; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; In Vitro Techniques; Male; Middle Aged; Platelet Aggregation | 2003 |
Desmopressin antagonizes the in vitro platelet dysfunction induced by GPIIb/IIIa inhibitors and aspirin.
Topics: Abciximab; Adenosine Diphosphate; Adult; Antibodies, Monoclonal; Aspirin; Collagen; Cross-Over Studies; Deamino Arginine Vasopressin; Dose-Response Relationship, Drug; Double-Blind Method; Epinephrine; Eptifibatide; Humans; Immunoglobulin Fab Fragments; Male; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Tirofiban; Tyrosine | 2003 |
Combination antiplatelet therapy in patients with peripheral vascular bypass grafts.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Drug Therapy, Combination; Female; Flow Cytometry; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Peripheral Vascular Diseases; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Prospective evaluation of the relationship between platelet-leukocyte conjugate formation and recurrent myocardial ischemia in patients with acute coronary syndromes.
Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Aged; Angina, Unstable; Arachidonic Acid; Aspirin; Blood Platelets; C-Reactive Protein; Cell Aggregation; Drug Resistance; Eptifibatide; Female; Heparin; Humans; Leukocytes; Male; Middle Aged; Monocytes; Multivariate Analysis; Myocardial Infarction; Myocardial Ischemia; Neutrophils; Patient Selection; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Receptors, Thrombin; Recurrence; ROC Curve; Tirofiban; Treatment Outcome; Troponin I; Tyrosine | 2004 |
The effect of clopidogrel, aspirin and both antiplatelet drugs on platelet function in patients with peripheral arterial disease.
Topics: Adenosine Diphosphate; Aged; Arteriosclerosis; Aspirin; Blood Platelets; Cell Shape; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; P-Selectin; Peripheral Vascular Diseases; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet-Derived Growth Factor; Serotonin; Ticlopidine | 2004 |
Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; CD40 Ligand; Clopidogrel; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Leukocytes; Male; Middle Aged; Myocardial Infarction; P-Selectin; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2004 |
Measurement of platelet aggregation during antiplatelet therapy in ischemic stroke.
Topics: Adenosine Diphosphate; Adult; Aspirin; Brain Ischemia; Clopidogrel; Cohort Studies; Collagen; Epinephrine; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Ticlopidine | 2004 |
The effect of ASA on platelet activation during apheresis and on in-vitro properties of stored platelet concentrates.
Topics: Adenosine Diphosphate; Adult; Aspirin; Biomarkers; Blood Preservation; Collagen; Cross-Over Studies; Female; Humans; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Male; Middle Aged; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Membrane Glycoprotein IIb; Platelet Transfusion; Plateletpheresis | 2004 |
Variable extent of clopidogrel responsiveness in patients after coronary stenting.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Cell Adhesion Molecules; Clopidogrel; Drug Therapy, Combination; Female; Flow Cytometry; GTP-Binding Protein alpha Subunits, Gi-Go; Heart Diseases; Humans; Male; Membrane Proteins; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Stents; Ticlopidine; Treatment Outcome | 2004 |
Enhanced antiplatelet effect of clopidogrel in patients whose platelets are least inhibited by aspirin: a randomized crossover trial.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Biomarkers; Clopidogrel; Collagen; Cross-Over Studies; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Peripheral Vascular Diseases; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Effect of platelet antigen polymorphism on platelet inhibition by aspirin, clopidogrel, or their combination.
Topics: Adenosine Diphosphate; Antigens, Human Platelet; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Artery Disease; Cytoplasmic Granules; Epinephrine; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Ticlopidine | 2006 |
Biological efficacy of low against medium dose aspirin regimen after coronary surgery: analysis of platelet function.
Topics: Adenosine Diphosphate; Administration, Oral; Adult; Aged; Aspirin; Blood Platelets; Collagen; Coronary Artery Bypass; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Complications; Thromboxane A2; Time Factors | 2006 |
Sex differences in platelet reactivity and response to low-dose aspirin therapy.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Cardiovascular Diseases; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Regression Analysis; Sex Factors | 2006 |
Biological efficacy of low versus medium dose aspirin after coronary surgery: results from a randomized trial [NCT00262275].
Topics: Adenosine Diphosphate; Aged; Aspirin; Collagen; Coronary Artery Bypass; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Treatment Outcome | 2006 |
Diabetes mellitus and platelet function after administration of aspirin and a single 600 mg dose of clopidogrel.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Artery Disease; Diabetes Complications; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Thrombin; Thrombosis; Ticlopidine | 2006 |
Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Celecoxib; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Ibuprofen; Male; Middle Aged; Myocardial Ischemia; Osteoarthritis; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Pyrazoles; Sulfonamides; Thromboxane B2; Treatment Outcome | 2006 |
Evidence that pre-existent variability in platelet response to ADP accounts for 'clopidogrel resistance'.
Topics: Adenosine Diphosphate; Adult; Aspirin; Bayes Theorem; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug Resistance; Female; Humans; Male; Middle Aged; Models, Cardiovascular; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Reference Values; Severity of Illness Index; Ticlopidine; Time Factors | 2007 |
Normalization of platelet reactivity in clopidogrel-treated subjects.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fibrinogen; Humans; Male; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Transfusion; Platelet-Rich Plasma; Postoperative Hemorrhage; Receptors, Thrombin; Recovery of Function; Reference Values; Ticlopidine; Time Factors | 2007 |
Lack of association between the 807 C/T polymorphism of glycoprotein Ia gene and post-treatment platelet reactivity after aspirin and clopidogrel in patients with acute coronary syndrome.
Topics: Acute Disease; Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cytosine; Female; France; Genotype; Humans; Integrin alpha2; Male; Microfilament Proteins; Middle Aged; Myocardial Ischemia; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Prospective Studies; Syndrome; Thymine; Ticlopidine; Treatment Outcome | 2007 |
Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin.
Topics: Adenosine Diphosphate; Administration, Oral; Adult; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Resistance; Female; Flow Cytometry; Humans; Male; Membrane Proteins; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Reference Values; Tablets, Enteric-Coated; Thromboxane B2 | 2007 |
Dose-dependent inhibition of human platelet aggregation by prasugrel and its interaction with aspirin in healthy subjects.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aspirin; Bleeding Time; Clopidogrel; Collagen; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Middle Aged; Peptide Fragments; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2007 |
Relationship between endothelial dysfunction, oxidant stress and aspirin resistance in patients with stable coronary heart disease.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Ascorbic Acid; Aspirin; Biomarkers; Coronary Disease; Drug Resistance; Endothelium, Vascular; Erythrocytes; Female; Humans; Lipid Peroxides; Lipoproteins; Male; Middle Aged; Oxidative Stress; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Superoxide Dismutase; Thrombomodulin; Vitamin E | 2007 |
Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Coronary Disease; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Female; Flow Cytometry; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Thrombelastography; Thromboxane B2 | 2007 |
The additive antiplatelet action of clopidogrel in patients with coronary artery disease treated with aspirin.
Topics: Adenosine Diphosphate; Adult; Aged; Aspirin; Biomarkers; Case-Control Studies; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Treatment Outcome | 2007 |
Effects of selective cyclooxygenase isoform inhibition on systemic prostacyclin synthesis and on platelet function at rest and after exercise in healthy volunteers.
Topics: Adenosine Diphosphate; Adult; Aspirin; Atherosclerosis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Endothelium; Epoprostenol; Exercise; Humans; Isoenzymes; Lactones; Male; Platelet Activation; Rest; Risk Factors; Sulfones; Thrombosis; Thromboxane B2 | 2007 |
Therapeutic benefit of low-dose clopidogrel in patients undergoing carotid surgery is linked to variability in the platelet adenosine diphosphate response and patients' weight.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Body Weight; Clopidogrel; Endarterectomy, Carotid; Humans; Placebos; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Complications; Statistics as Topic; Thrombosis; Ticlopidine | 2007 |
Platelet function measured by VerifyNow identifies generalized high platelet reactivity in aspirin treated patients.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Collagen; Coronary Artery Disease; Cross-Over Studies; Double-Blind Method; Female; Fibrinogen; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; von Willebrand Factor | 2007 |
Comparison of cationic propyl gallate and adenosine diphosphate for the measurement of aspirin effectivity with optical aggregometry.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Case-Control Studies; Cations; Drug Resistance; Humans; In Vitro Techniques; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Propyl Gallate; Sensitivity and Specificity | 2007 |
Effect of high dose statin therapy on platelet function; statins reduce aspirin-resistant platelet aggregation in patients with coronary heart disease.
Topics: Adenosine Diphosphate; Adult; Aged; Aspirin; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Collagen; Coronary Disease; Diabetes Complications; Drug Resistance; Epinephrine; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; Pyrroles; Smoking | 2009 |
Effect of clopidogrel treatment on stress-induced platelet activation and myocardial ischemia in aspirin-treated patients with stable coronary artery disease.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; C-Reactive Protein; CD40 Ligand; Clopidogrel; Collagen; Coronary Artery Disease; Double-Blind Method; Drug Therapy, Combination; Electrocardiography, Ambulatory; Exercise Test; Flow Cytometry; Heart Rate; Humans; Interleukin-6; Leukocytes; Male; Middle Aged; Myocardial Ischemia; P-Selectin; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Research Design; Stress, Physiological; Thrombin; Ticlopidine; Treatment Outcome | 2007 |
The significance of vasodilator-stimulated phosphoprotein for risk stratification of stent thrombosis.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cell Adhesion Molecules; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Reproducibility of Results; Research Design; Risk Assessment; Risk Factors; ROC Curve; Sensitivity and Specificity; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
Variable responsiveness to clopidogrel and aspirin among patients with acute coronary syndrome as assessed by platelet function tests.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet-Rich Plasma; ROC Curve; Sensitivity and Specificity; Ticlopidine | 2008 |
Platelet inhibition by low-dose aspirin but not by clopidogrel reduces the axon-reflex current-induced vasodilation in humans.
Topics: Acetylcholine; Adenosine Diphosphate; Adult; Aspirin; Axons; Blood Platelets; Clopidogrel; Electric Stimulation; Endothelium, Vascular; Female; Humans; Iontophoresis; Laser-Doppler Flowmetry; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Signal Transduction; Ticlopidine; Vasodilation; Vasodilator Agents | 2008 |
Action of aspirin on whole blood-aggregation evaluated by the screen filtration pressure method.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Filtration; Hematologic Tests; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Pressure | 2008 |
Switching directly to prasugrel from clopidogrel results in greater inhibition of platelet aggregation in aspirin-treated subjects.
Topics: Adenosine Diphosphate; Adult; Aspirin; Clopidogrel; Drug-Related Side Effects and Adverse Reactions; Female; Hemorrhage; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2008 |
Increased platelet sensitivity among individuals with aspirin resistance - platelet aggregation to submaximal concentration of arachidonic acid predicts response to antiplatelet therapy.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Receptors, Thromboxane; Reference Values; Thromboxane B2; Treatment Failure | 2008 |
Effects of aspirin and clopidogrel in healthy men measured by platelet aggregation and PFA-100.
Topics: Adenosine Diphosphate; Adolescent; Adult; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Epinephrine; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reference Values; Ticlopidine | 2008 |
ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assay.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Clopidogrel; Comorbidity; Coronary Artery Disease; Drug Resistance; Female; Flow Cytometry; Humans; Incidence; Male; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Ticlopidine | 2008 |
Effect of increased aspirin dose after stenting in association with ClOpidogrel: the FIASCO randomized study.
Topics: Adenosine Diphosphate; Aged; Angina Pectoris; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Comparison of collagen versus adenosine diphosphate in detecting antiplatelet effect in patients with coronary artery disease.
Topics: Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Collagen; Coronary Artery Disease; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Ticlopidine; Treatment Outcome | 2009 |
Thrombotic events in high risk patients are predicted by evaluating different pathways of platelet function.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Likelihood Functions; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Prospective Studies; Reproducibility of Results; Risk Assessment; Risk Factors; ROC Curve; Thrombosis; Ticlopidine | 2008 |
Comparison of methods to evaluate clopidogrel-mediated platelet inhibition after percutaneous intervention with stent implantation.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Reproducibility of Results; Sensitivity and Specificity; Stents; Ticlopidine | 2009 |
Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: implications for aspirin "resistance".
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Resistance; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombopoietin; Thromboxane B2; Young Adult | 2009 |
Low molecular weight heparin significantly reduces embolisation after carotid endarterectomy--a randomised controlled trial.
Topics: Adenosine Diphosphate; Aged; Anticoagulants; Arachidonic Acid; Aspirin; Carotid Artery Diseases; Dalteparin; Double-Blind Method; Drug Therapy, Combination; Endarterectomy, Carotid; Female; Hemorrhage; Heparin; Humans; Infusions, Intravenous; Intracranial Embolism; Male; Middle Aged; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Assessment; Stroke; Time Factors; Treatment Outcome; Ultrasonography, Doppler, Transcranial | 2009 |
Cross validation of the Multiple Electrode Aggregometry. A prospective trial in healthy volunteers.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Arachidonic Acid; Aspirin; Clopidogrel; Electrodes; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine; Time Factors; Young Adult | 2009 |
Clopidogrel provides significantly greater inhibition of platelet activity than aspirin when combined with atorvastatin after coronary artery bypass grafting: a prospective randomized study.
Topics: Adenosine Diphosphate; Aged; Aspirin; Atorvastatin; Clopidogrel; Comorbidity; Coronary Artery Bypass; Coronary Disease; Drug Therapy, Combination; Female; Fibrinogen; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lipoproteins, LDL; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Complications; Prospective Studies; Pyrroles; Ticlopidine | 2010 |
Effect of age on the pharmacokinetics and pharmacodynamics of prasugrel during multiple dosing: an open-label, single-sequence, clinical trial.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aging; Aspirin; Bleeding Time; Body Mass Index; Confidence Intervals; Drug Therapy, Combination; Fasting; Female; Humans; Least-Squares Analysis; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Statistics, Nonparametric; Tablets, Enteric-Coated; Thiophenes; Young Adult | 2009 |
The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: first experience in patients.
Topics: Adenosine Diphosphate; Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; Blood Coagulation; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Collagen; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Therapy, Combination; Female; Gene Frequency; Genotype; Humans; Male; Microfilament Proteins; Middle Aged; Phenotype; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Purinergic P2 Receptor Antagonists; Quinazolinones; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stents; Sulfonamides; Thrombelastography; Ticlopidine | 2010 |
Stroke and aspirin non-responder patients: relation with hypertension and platelet response to adenosine diphosphate.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Female; Humans; Hypertension; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Prospective Studies; Stroke | 2009 |
Adding cilostazol to dual antiplatelet therapy achieves greater platelet inhibition than high maintenance dose clopidogrel in patients with acute myocardial infarction: Results of the adjunctive cilostazol versus high maintenance dose clopidogrel in patie
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Blood Vessel Prosthesis Implantation; Cells, Cultured; Chemotherapy, Adjuvant; Cilostazol; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Tetrazoles; Ticlopidine | 2010 |
Dose-related effect of aspirin on laboratory-defined platelet aggregation and clinical outcome after coronary stenting.
Topics: Adenosine Diphosphate; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Chi-Square Distribution; Coronary Artery Disease; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Female; Humans; Iran; Male; Middle Aged; Myocardial Infarction; Myocardial Perfusion Imaging; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Assessment; Risk Factors; Sex Factors; Smoking; Stents; Time Factors; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2010 |
[Effect of tongxinluo capsule on platelet aggregation function in patients with aspirin resistance].
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aspirin; Collagen; Coronary Disease; Drug Resistance; Drugs, Chinese Herbal; Female; Humans; Male; Middle Aged; Platelet Aggregation | 2010 |
Thromboxane Antagonism with terutroban in Peripheral Arterial Disease: the TAIPAD study.
Topics: Adenosine Diphosphate; Adult; Aged; Aspirin; Blood Pressure; Double-Blind Method; Female; Humans; Male; Middle Aged; Naphthalenes; Peripheral Arterial Disease; Placebos; Platelet Aggregation; Propionates; Thromboxanes; Time Factors | 2010 |
Comparison between the effect of omeprazole and rabeprazole on the antiplatelet action of clopidogrel.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Interactions; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabeprazole; Ticlopidine; Treatment Outcome | 2010 |
Variability and persistence of aspirin response in lower extremity peripheral arterial disease patients.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon; Arachidonic Acid; Aspirin; Azetidines; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Ezetimibe; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Lower Extremity; Male; Middle Aged; Niacin; Peripheral Arterial Disease; Placebo Effect; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Stents; Time Factors; Treatment Outcome | 2011 |
Platelet inhibition by adjunctive cilostazol versus high maintenance-dose clopidogrel in patients with acute myocardial infarction according to cytochrome P450 2C19 genotype.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; Chi-Square Distribution; Cilostazol; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; Genotype; Humans; Korea; Liver; Male; Middle Aged; Myocardial Infarction; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Regression Analysis; Risk Assessment; Risk Factors; Tetrazoles; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Impact of platelet reactivity to adenosine diphosphate before implantation of drug-eluting stents on subsequent adverse cardiac events in patients with stable angina.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Angina, Stable; Aspirin; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Reversal of the anti-platelet effects of aspirin and clopidogrel.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Biomarkers; Blood Platelets; Clopidogrel; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Ontario; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Transfusion; Recovery of Function; Thromboxane B2; Ticlopidine; Time Factors | 2012 |
[Comparative evaluation of antiplatelet efectiveness drugs of original and reproduced enteric forms of acetylsalicylic acid (clinical study ICAR))].
Topics: Adenosine Diphosphate; Administration, Oral; Aged; Aspirin; Cardiovascular Diseases; Dosage Forms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Therapeutic Equivalency; Treatment Outcome | 2012 |
Accelerated platelet inhibition by switching from atorvastatin to a non-CYP3A4-metabolized statin in patients with high platelet reactivity (ACCEL-STATIN) study.
Topics: Adenosine Diphosphate; Aspirin; Atorvastatin; Calcium Channel Blockers; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP3A; Drug Substitution; Drug Therapy, Combination; Female; Fluorobenzenes; Genotype; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Pravastatin; Prospective Studies; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides; Ticlopidine | 2012 |
The in vitro effects of verbascoside on human platelet aggregation.
Topics: Adenosine Diphosphate; Adult; Aged; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Coronary Disease; Female; Glucosides; Humans; Male; Middle Aged; Phenols; Platelet Aggregation | 2012 |
Relation between clopidogrel active metabolite levels and different platelet aggregation methods in patients receiving clopidogrel and aspirin.
Topics: Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prodrugs; Ticlopidine; Time Factors | 2012 |
Resistance to low-dose aspirin therapy among patients with acute coronary syndrome in relation to associated risk factors.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aspirin; Collagen; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Factors; Thromboxane B2 | 2012 |
Aspirin attenuates platelet activation and immune activation in HIV-1-infected subjects on antiretroviral therapy: a pilot study.
Topics: Adenosine Diphosphate; Adult; Aged; Anti-HIV Agents; Arachidonic Acid; Aspirin; Cells, Cultured; Collagen; Female; HIV Infections; HIV-1; Humans; Inflammation; Lymphocyte Activation; Male; Middle Aged; P-Selectin; Pilot Projects; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxanes; Young Adult | 2013 |
Transient heparin-induced platelet activation linked to generation of platelet 12-lipoxygenase. Findings from a randomised controlled trial.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adenosine Diphosphate; Aged; Arachidonate 12-Lipoxygenase; Aspirin; Blood Platelets; Dalteparin; Endarterectomy, Carotid; Female; Gene Expression Regulation, Enzymologic; Heparin; Humans; Lipase; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Thromboxane B2 | 2013 |
Effects of vorapaxar on platelet reactivity and biomarker expression in non-ST-elevation acute coronary syndromes. The TRACER Pharmacodynamic Substudy.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Aspirin; Biomarkers; Blood Platelets; Cells, Cultured; Europe; Female; Follow-Up Studies; Humans; Inflammation Mediators; Lactones; Male; Middle Aged; North America; Platelet Aggregation; Pyridines; Receptor, PAR-1; Receptors, Thrombin | 2014 |
Aspirin decreases systemic exposure to clopidogrel through modulation of P-glycoprotein but does not alter its antithrombotic activity.
Topics: Adenosine Diphosphate; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Fibrinolytic Agents; Genotype; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; RNA, Messenger; Ticlopidine | 2014 |
Monitoring the efficacy of ADP inhibitor treatment in patients with acute STEMI post-PCI by VASP-P flow cytometry assay.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Female; Flow Cytometry; Follow-Up Studies; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Phosphoproteins; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2015 |
Switching from generic to brand clopidogrel in male patients after ST-elevated myocardial infarction.
Topics: Adenosine Diphosphate; Aspirin; Clopidogrel; Drug Substitution; Drug Therapy, Combination; Drugs, Generic; Epinephrine; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2014 |
The effectiveness of low-dose desmopressin in improving hypothermia-induced impairment of primary haemostasis under influence of aspirin - a randomized controlled trial.
Topics: Adenosine Diphosphate; Aspirin; Collagen; Deamino Arginine Vasopressin; Double-Blind Method; Epinephrine; Female; Follow-Up Studies; Hemostasis; Hemostatics; Humans; Hypothermia; Male; Platelet Function Tests | 2015 |
Temporal variability in the antiplatelet effects of clopidogrel and aspirin after elective drug-eluting stent implantation. An ADAPT-DES substudy.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Elective Surgical Procedures; Female; Germany; Humans; Male; Middle Aged; Observer Variation; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Purinergic P2Y12; Ticlopidine | 2015 |
Effect of Vorapaxar Alone and in Combination with Aspirin on Bleeding Time and Platelet Aggregation in Healthy Adult Subjects.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Bleeding Time; Blood Coagulation Tests; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Lactones; Male; Middle Aged; Platelet Aggregation; Pyridines; Receptors, Thrombin; Young Adult | 2016 |
Diurnal Variability of On-Treatment Platelet Reactivity in Clopidogrel versus Prasugrel Treated Acute Coronary Syndrome Patients: A Pre-Specified TROPICAL-ACS Sub-Study.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Circadian Rhythm; Clopidogrel; Double-Blind Method; Drug Administration Schedule; Drug Delivery Systems; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Receptors, Purinergic P2Y12; Time Factors | 2019 |
Reversal of the antiplatelet effect of ticagrelor by simulated platelet transfusion.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Female; Healthy Volunteers; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Transfusion; Ticagrelor; Young Adult | 2019 |
Differential Effects of Clopidogrel With or Without Aspirin on Platelet Reactivity and Coagulation Activation: A Randomized Trial in Healthy Volunteers.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; beta-Thromboglobulin; Blood Coagulation; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Drug Therapy, Combination; Healthy Volunteers; Humans; Male; Microfilament Proteins; P-Selectin; Phosphoproteins; Platelet Aggregation Inhibitors; Thromboxane B2; Whole Blood Coagulation Time; Young Adult | 2021 |
Effects of ticagrelor monotherapy vs. clopidogrel monotherapy on platelet reactivity: a randomized, crossover clinical study (SINGLE study).
Topics: Adenosine; Adenosine Diphosphate; Aspirin; Blood Platelets; Clopidogrel; Cross-Over Studies; Epinephrine; Fibrinolytic Agents; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticagrelor; Treatment Outcome | 2022 |
Platelet inhibition by low-dose aspirin is not influenced by body mass or weight.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Body Weight; Collagen; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests | 2022 |
Impact of diabetes mellitus on the pharmacodynamic effects of prasugrel and ticagrelor after switching from clopidogrel in patients with coronary artery disease.
Topics: Adenosine; Adenosine Diphosphate; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Ticagrelor | 2022 |
Effects of exercise on platelet reactivity after myocardial infarction: a randomized clinical trial.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors | 2023 |
699 other study(ies) available for aspirin and adenosine diphosphate
| Article | Year |
|---|---|
Identification of a promising drug candidate for the treatment of type 2 diabetes based on a P2Y(1) receptor agonist.
Topics: Animals; Blood Glucose; Cell Line, Tumor; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Molecular Structure; Purinergic P2Y Receptor Agonists; Rats; Rats, Wistar | 2012 |
Ditazole and platelets. I. Effect of ditazole on human platelet function in vitro.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation Tests; Carbon Radioisotopes; Humans; Indomethacin; Oxazoles; Platelet Aggregation; Serotonin; Thrombelastography | 1977 |
Acute hypotension due to carrageenan, arachidonic acid and slow reacting substance C in the rabbit: role of platelets and nature of pharmacological antagonism.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Aspirin; Autacoids; Blood Cell Count; Blood Platelets; Blood Pressure; Carrageenan; Drug Antagonism; Female; Glycogen; Immune Sera; In Vitro Techniques; Male; Platelet Aggregation; Prostaglandins; Rabbits; Respiration; Salicylates; Time Factors | 1977 |
Factors responsible for ADP-induced release reaction of human platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Citrates; Fibrinogen; gamma-Globulins; Hemophilia A; Heparin; Hirudins; Humans; Magnesium; Phenylbutazone; Phosphates; Platelet Adhesiveness; Platelet Aggregation; Serum Albumin; Sulfinpyrazone; Thrombin | 1975 |
A new abnormality of platelet functions. Association of storage pool disease (thrombocytopathia A) with impaired reactivity of platelets to collagen.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelet Disorders; Blood Platelets; Collagen; Fibrinogen; Glucuronidase; Humans; Male; Platelet Aggregation; Serotonin | 1975 |
Platelet activation in acute cerebral ischaemia. Serial measurements of platelet function in cerebrovascular disease.
Topics: Acute Disease; Adenosine Diphosphate; Aged; Aspirin; Blood Cell Count; Blood Platelets; Cerebrovascular Disorders; Chronic Disease; Collagen; Dipyridamole; Epinephrine; Humans; In Vitro Techniques; Ischemic Attack, Transient; Middle Aged; Platelet Aggregation | 1977 |
Inhibition of platelet aggregation during hypovolemic hypotension by acetylsalicylic acid and artificial respiration.
Topics: Adenosine Diphosphate; Animals; Aspirin; Dogs; Histamine Release; Hypotension; Platelet Aggregation; Prostaglandins; Respiration, Artificial; Serotonin; Shock | 1979 |
[Clinical aspects of control in therapy with platelet inhibitors].
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation Tests; Blood Platelets; Coronary Disease; Fibrin; Humans; Platelet Adhesiveness; Platelet Aggregation; Platelet Factor 4; Propranolol | 1979 |
[Prevention of cardiovascular complications in manifest arteriosclerosis by the use of Micristine].
Topics: Adenosine Diphosphate; Anticoagulants; Arteriosclerosis; Aspirin; Cardiovascular Diseases; Humans; Platelet Aggregation | 1979 |
Meseclazone, 5-chlorosalicylic acid and acetylsalicylic acid. Comparison of their effects on in vitro and ex vivo platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Anti-Inflammatory Agents; Aspirin; Blood Coagulation Tests; Collagen; Guinea Pigs; Male; Oxazines; Platelet Aggregation; Rats; Salicylates; Thrombin | 1978 |
Effect of arachidonic acid on some inhibitors of the human platelet release reaction.
Topics: Adenosine Diphosphate; Arachidonic Acids; Aspirin; Blood Platelets; Edetic Acid; Epinephrine; Humans; In Vitro Techniques; Serotonin | 1978 |
In vitro effect of the coronary vasodilator diltiazem on human and rabbit platelets.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Aspirin; Benzazepines; Blood Platelets; Calcium; Collagen; Diltiazem; Egtazic Acid; Humans; Indomethacin; Male; Platelet Aggregation; Rabbits; Vasodilator Agents | 1978 |
Effects of carrageenans on the aggregation of human blood platelets.
Topics: Adenosine Diphosphate; Apyrase; Aspirin; Blood Coagulation Tests; Carrageenan; Egtazic Acid; Humans; Male; Platelet Aggregation; Theophylline; Thrombin | 1979 |
A circulating inhibitor of platelet aggregation in Bartter's syndrome.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aspirin; Bartter Syndrome; Bleeding Time; Collagen; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Epinephrine; Humans; Hyperaldosteronism; Infant; Middle Aged; Platelet Aggregation | 1979 |
Effect of oral aspirin on "ecto-ATPase" activity of washed human platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adult; Aspirin; Blood Platelets; Humans; In Vitro Techniques; Male; Platelet Aggregation; Time Factors | 1978 |
Effects of gliclazide, a new antidiabetic agent, on the platelet release reaction, role of adenylate cyclase.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Aspirin; Carbon Radioisotopes; Collagen; Cyclic AMP; Dipyridamole; Gliclazide; Glucuronidase; Humans; Phosphoric Diester Hydrolases; Platelet Adhesiveness; Prostaglandins E; Serotonin; Sulfonylurea Compounds; Thrombin; Tritium | 1975 |
[Experimental studies on mechanism of inhibition of thrombocyte aggregation caused by sulfonyl ureas. 1. Problems and methods].
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Glucose; Cyclic AMP; Depression, Chemical; In Vitro Techniques; Insulin; Liver; Male; Methods; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins; Protein Binding; Rats; Sulfonylurea Compounds; Temperature; Theophylline; Tolbutamide; Tritium | 1975 |
In vitro evaluation of inhibitors of platelet release and aggregation.
Topics: Adenosine; Adenosine Diphosphate; Anti-Inflammatory Agents; Antilymphocyte Serum; Aspirin; Blood Platelets; Collagen; Depression, Chemical; Dextrans; Dipyridamole; Epinephrine; Hematology; Humans; Molecular Weight; Phosphoric Monoester Hydrolases; Platelet Adhesiveness; Platelet Aggregation; Propionates; Prostaglandins E; Serotonin; Sulfinpyrazone; T-Lymphocytes | 1975 |
Platelet aggregometry and anti-platelet isoantibodies.
Topics: Adenosine; Adenosine Diphosphate; Adenylate Kinase; Animals; Antilymphocyte Serum; Aspirin; Blood Platelets; Bucladesine; Heparin; HLA Antigens; Immune Sera; Isoantibodies; Platelet Aggregation; Platelet Factor 3; Platelet Factor 4; Prostaglandins E; Snake Venoms; Thrombin | 1975 |
Cyclic AMP in human blood platelets: relation to platelet prostaglandin synthesis induced by centrifugation or surface contact.
Topics: Adenosine Diphosphate; Aspirin; Binding Sites; Blood Platelets; Cell Membrane; Collagen; Cyclic AMP; Epinephrine; Humans; Kinetics; Polyvinyls; Prostaglandins E; Prostaglandins F; Serotonin; Thrombin | 1976 |
Roles of cyclic nucleotides in platelet function.
Topics: Acetylcholine; Adenosine Diphosphate; Adenylyl Cyclases; Arginine Vasopressin; Aspirin; Blood Platelets; Calcium; Carbachol; Collagen; Cyclic AMP; Cyclic GMP; Epinephrine; Humans; In Vitro Techniques; Indomethacin; Papaverine; Platelet Aggregation; Prostaglandins E | 1975 |
Enzyme activities on the platelet surface in relation to the action of adenosine diphosphate.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aspirin; Blood Platelets; Bucladesine; Cell Membrane; Edetic Acid; Egtazic Acid; Humans; Hydroxylamines; In Vitro Techniques; Nucleosides; Nucleotides; Phosphotransferases; Platelet Aggregation; Prostaglandins E; Rabbits | 1975 |
Classification of platelet aggregation patterns with two ADP solutions (the double-ADP method) and its clinical application to diabetes mellitus.
Topics: Adenosine Diphosphate; Adult; Aged; Aging; Aspirin; Blood Glucose; Cholesterol; Diabetes Mellitus; Dose-Response Relationship, Drug; Energy Intake; Fats; Fatty Acids, Nonesterified; Female; Humans; Lipoproteins, LDL; Male; Middle Aged; Platelet Aggregation | 1977 |
Aggregation of gel-filtered guinea-pig platelets by lipoproteins.
Topics: Adenosine; Adenosine Diphosphate; Animals; Apyrase; Aspirin; Chromatography, Gel; Dipyridamole; Guinea Pigs; Lipoproteins; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Platelet Aggregation; Prostaglandins E | 1979 |
[Aspirin-like defect - a hereditary thrombocytopathy due to impaired release of platelet adenosine diphosphate].
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelet Disorders; Blood Platelets; Collagen; Epinephrine; Female; Humans; Platelet Adhesiveness; Platelet Aggregation | 1979 |
Platelet storage pool deficiency and prostaglandin synthesis in chronic granulocytic leukaemia.
Topics: Adenosine Diphosphate; Adolescent; Adult; Arachidonic Acids; Aspirin; Blood Platelets; Child; Collagen; Epinephrine; Female; Humans; Leukemia, Myeloid; Male; Platelet Aggregation; Prostaglandins; Serotonin | 1978 |
Potentiation of platelet aggregation by heat-precipitated plasma proteins.
Topics: Adenosine Diphosphate; Aspirin; Blood Proteins; Chemical Precipitation; Collagen; Epinephrine; Fibrinogen; Hemophilia A; Hot Temperature; Humans; Immunoglobulin G; In Vitro Techniques; Platelet Aggregation; von Willebrand Diseases | 1978 |
Changes in platelet function and gastrointestinal bleeding following repeated administration of acetylsalicylic acid in the rat and the dog.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Collagen; Dogs; Gastrointestinal Hemorrhage; Male; Platelet Aggregation; Rats; Species Specificity; Time Factors | 1979 |
Mechanisms of platelet shape change, aggregation, and release induced by collagen, thrombin, or A23,187.
Topics: Adenosine Diphosphate; Animals; Anti-Bacterial Agents; Arachidonic Acids; Aspirin; Blood Platelets; Calcimycin; Collagen; Creatine Kinase; Dose-Response Relationship, Drug; Humans; Indomethacin; Malondialdehyde; Phosphocreatine; Platelet Aggregation; Rabbits; Serotonin; Thrombin | 1977 |
The effect of indomethacin and ASA on in vivo induced white platelet arterial thrombus formation.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Blood Platelets; Epoprostenol; Indomethacin; Male; Mesenteric Arteries; Prostaglandins G; Prostaglandins H; Rats; Time Factors | 1978 |
The influence of age, sex, and the use of oral contraceptives on the inhibitory effects of endothelial cells and PGI2 (prostacyclin) on platelet function.
Topics: Adenosine Diphosphate; Adult; Age Factors; Aged; Aspirin; Blood Cell Count; Blood Platelets; Cells, Cultured; Collagen; Contraceptives, Oral; Contraceptives, Oral, Combined; Endothelium; Epoprostenol; Female; Humans; Lipids; Male; Malondialdehyde; Menopause; Middle Aged; Platelet Aggregation; Platelet Factor 3; Prostaglandins; Sex Factors | 1978 |
The role of platelet-activating factor in platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation Factors; Calcimycin; Calcium; Creatine Kinase; Humans; Lysophosphatidylcholines; Phosphocreatine; Phospholipases; Platelet Aggregation; Rabbits; Thromboxane A2 | 1979 |
Generation of a PGI2-like activity by deendothelialized rat aorta.
Topics: Adenosine Diphosphate; Animals; Aorta, Abdominal; Aspirin; Collagen; Endothelium; Epoprostenol; Female; Humans; Male; Partial Thromboplastin Time; Platelet Adhesiveness; Platelet Aggregation; Platelet Factor 3; Prostaglandins; Rats; Thrombin Time | 1979 |
Evidence for the mechanism by which eicosapentaenoic acid inhibits human platelet aggregation and secretion - implications for the prevention of vascular disease.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Calcimycin; Collagen; Eicosanoic Acids; Epinephrine; Epoprostenol; Fatty Acids, Unsaturated; Humans; Platelet Aggregation; Rats; Vascular Diseases | 1979 |
Prostaglandins as inhibitors of human platelet aggregation.
Topics: Adenosine Diphosphate; Arachidonic Acids; Aspirin; Collagen; Depression, Chemical; Epinephrine; Epoprostenol; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandins D; Prostaglandins E, Synthetic; Prostaglandins, Synthetic | 1979 |
Reversible acylation and inhibition of aggregation of platelets by substituted maleic anhydrides.
Topics: Acylation; Adenosine Diphosphate; Aspirin; Blood Platelets; Epinephrine; Female; Furans; Humans; In Vitro Techniques; Male; Maleic Anhydrides; Mixed Function Oxygenases; Nephelometry and Turbidimetry; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Time Factors | 1977 |
Aspirin-induced increase in collateral flow after acute coronary occlusion in dogs.
Topics: Acute Disease; Adenosine Diphosphate; Animals; Arterial Occlusive Diseases; Aspirin; Collateral Circulation; Coronary Vessels; Dogs; Female; Male; Platelet Aggregation; Time Factors | 1979 |
Effect of anti-P1A1 antibody on human platelets. II. Mechanism of the complement-dependent release reaction.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Antibodies; Aspirin; Blood Platelets; Complement System Proteins; Humans; Phosphodiesterase Inhibitors; Platelet Factor 4; Prostaglandins E; Serotonin | 1979 |
Release of platelet fibronectin (cold-insoluble globulin) from alpha granules induced by thrombin or collagen; lack of requirement for plasma fibronectin in ADP-induced platelet aggregation.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Collagen; Cytoplasmic Granules; Humans; Platelet Aggregation; Serum Globulins; Thrombin | 1979 |
Aggregation of human platelets in an annular vortex distal to a tubular expansion.
Topics: Adenosine Diphosphate; Aspirin; Blood Circulation; Coagulants; Heparin; Humans; Particle Size; Platelet Aggregation; Pulse; Temperature | 1979 |
Phenylbutazone inhibition of equine platelet function.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Horses; Malondialdehyde; Phenylbutazone; Platelet Aggregation; Prostaglandins; Thrombin; Thromboxanes | 1979 |
Effect of platelet activation on the platelet surface sialic acid.
Topics: Adenosine; Adenosine Diphosphate; Aspirin; Blood Platelets; Cell Membrane; Collagen; Epinephrine; Humans; Neuraminidase; Sialic Acids; Thrombin | 1979 |
In vitro effect of levamisole on oxygen consumption and survival of platelets.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Cell Survival; Drug Interactions; Humans; In Vitro Techniques; Levamisole; Oxygen Consumption; Platelet Aggregation; Thrombin | 1979 |
Platelet aggregation following exposure of phospholipase-treated platelet rich plasma to hydrogen peroxide.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Catalase; Collagen; Dose-Response Relationship, Drug; Epinephrine; Furosemide; Hydrogen Peroxide; Mercaptoethanol; Phospholipases; Phospholipases A; Platelet Aggregation; Thrombin; Time Factors | 1979 |
Platelet function in the neonate.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Arachidonic Acids; Aspirin; Blood Platelet Disorders; Blood Platelets; Collagen; Epinephrine; Hemostasis; Humans; Infant, Newborn; Infant, Newborn, Diseases; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins; Serotonin; Thrombin | 1979 |
[Modifications of platelet function induced by ASA. I. Effects on aggregation].
Topics: Adenosine Diphosphate; Adult; Aspirin; Collagen; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Time Factors | 1979 |
Cycles of agglutination-disagglutination induced by ristocetin in thrombasthenic platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Aspirin; Child; Child, Preschool; Creatine Kinase; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Periodicity; Phosphocreatine; Platelet Aggregation; Purpura, Thrombocytopenic; Ristocetin; Time Factors | 1979 |
Kinetic parameters of platelet aggregation as an expression of platelet responsiveness.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Citrates; Collagen; Humans; Kinetics; Platelet Aggregation | 1977 |
Spontaneous platelet aggregation in cerebrovascular disease.
Topics: Adenosine; Adenosine Diphosphate; Adult; Aged; Aspirin; Blindness; Brain Diseases; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Paresthesia; Phentolamine; Platelet Aggregation | 1978 |
The effects of treatment with aspirin and an antithrombotic agent SH1117 upon platelet thrombus formation in living blood vessels.
Topics: Adenosine Diphosphate; Animals; Aspirin; Biphenyl Compounds; Drug Synergism; Fibrinolytic Agents; Male; Platelet Aggregation; Rabbits; Sulfones; Thrombosis | 1977 |
Platelet effects of arachidonic acid in dog blood. I. Lack of involvement of cyclo-oxygenase in the in vivo situation.
Topics: Adenosine Diphosphate; Ancrod; Animals; Arachidonic Acids; Aspirin; Blood Platelets; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Female; Indomethacin; Linoleic Acids; Male; Oxygenases; Platelet Aggregation; Prostaglandins E; Pyrogallol; Thrombin; Thrombocytopenia | 1977 |
Effect of three nonsteroidal anti-inflammatory agents on platelet function and prostaglandin synthesis in vitro.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Ibuprofen; In Vitro Techniques; Male; Naproxen; Platelet Aggregation; Prostaglandin Antagonists; Prostaglandins | 1978 |
Role of platelets in aspirin-sensitive bronchoconstriction in the guinea-pig; interactions with salicylic acid.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Apyrase; Arachidonic Acids; Aspirin; Blood Platelets; Bradykinin; Bronchi; Drug Synergism; Guinea Pigs; Platelet Aggregation; Salicylates | 1978 |
Kinetics of aggregation of human platelets.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Hematologic Tests; Humans; In Vitro Techniques; Kinetics; Platelet Aggregation; Prostaglandins E; Prostaglandins E, Synthetic; Prostaglandins F, Synthetic | 1978 |
The inhibitory effect of human endothelial cell monolayers on platelet reactions and its inhibition by aspirin.
Topics: Adenosine Diphosphate; Aspirin; Collagen; Endothelium; Humans; In Vitro Techniques; Platelet Aggregation | 1978 |
A platelet procoagulant activity associated with platelet shape change.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation; Blood Coagulation Factors; Blood Platelets; Cell Membrane; Humans; Male; Platelet Aggregation; Prothrombin Time | 1978 |
Acetylsalicylic acid and the cardiovascular effects of ADP in the rat.
Topics: Adenosine Diphosphate; Animals; Arrhythmias, Cardiac; Aspirin; Blood Pressure; Coronary Disease; Male; Platelet Aggregation; Rats | 1978 |
[ITA 104, a product of antiplatelet aggregation activity].
Topics: Adenosine Diphosphate; Animals; Aspirin; Clofibrate; Clofibric Acid; Depression, Chemical; Dogs; Platelet Aggregation; Rats | 1978 |
Inhibitory effect of tiaramide on ADP-induced aggregation in rabbit platelets.
Topics: Adenosine Diphosphate; Animals; Aspirin; Benzothiazoles; Indomethacin; Piperazines; Platelet Aggregation; Rabbits; Thiazoles | 1978 |
[Significance of two concentrations of adenosine diphosphate inducing platelet aggregation in patients with diabetes mellitus (author's transl)].
Topics: Adenosine Diphosphate; Adult; Aged; Aging; Aspirin; Diabetes Mellitus; Diabetic Retinopathy; Female; Humans; Male; Middle Aged; Platelet Aggregation | 1978 |
Platelet aggregation induced by antilymphocyte serum. I. Differences between washed and unwashed platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antilymphocyte Serum; Aspirin; Blood Platelets; Calcium Chloride; Complement C3; Edetic Acid; Goats; Heparin; Horses; Humans; Magnesium; Mersalyl; Platelet Aggregation; Prostaglandins E; Tetanus Antitoxin | 1975 |
Antiplatelet and antithrombogenic effects of suloctidil.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Pressure; Dogs; Female; Fibrinolytic Agents; Haplorhini; Male; Mice; Mice, Inbred Strains; Platelet Aggregation; Propanolamines; Rats; Thrombophlebitis; Thrombosis | 1976 |
Altered platelet function in diabetes mellitus.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Cyclooxygenase Inhibitors; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; von Willebrand Factor | 1976 |
[Influence of acute exertion and physical training on platelet function of the coronary patient].
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Coronary Disease; Fibrinogen; Humans; Lipids; Male; Middle Aged; Myocardial Infarction; Physical Exertion; Platelet Adhesiveness; Platelet Aggregation | 1976 |
The effects of dopamine on human platelet aggregation, in vitro.
Topics: Adenosine Diphosphate; Aspirin; Collagen; Dopamine; Dopamine Antagonists; Drug Interactions; Epinephrine; Haloperidol; Humans; In Vitro Techniques; Male; Metaraminol; Phentolamine; Platelet Aggregation; Propranolol; Time Factors | 1977 |
Failure of certain antiplatelet drugs to affect myointimal thickening following arterial endothelial injury in the rat.
Topics: Adenosine Diphosphate; Air; Animals; Aspirin; Blood Coagulation Tests; Blood Platelets; Carotid Arteries; Clot Retraction; Collagen; Endothelium; Flurbiprofen; Hyperplasia; Male; Mesentery; Models, Biological; Muscle, Smooth; Platelet Aggregation; Propionates; Rats; Regeneration; Reserpine; Thrombin | 1977 |
Comparable inhibition of aggregation of PRP of neonates and adults by aspirin.
Topics: Adenosine Diphosphate; Adult; Aging; Aspirin; Collagen; Dose-Response Relationship, Drug; Epinephrine; Humans; Infant, Newborn; Platelet Aggregation; Ristocetin | 1977 |
The synergistic effect of aspirin and dipyridamole upon platelet thrombi in living blood vessels.
Topics: Adenosine Diphosphate; Alloxan; Animals; Aspirin; Dipyridamole; Drug Synergism; Male; Platelet Aggregation; Rabbits; Thrombosis | 1977 |
Collagen-induced platelet aggregation: evidence of several mechanisms for the induction of platelet release by collagen.
Topics: Adenosine Diphosphate; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Epinephrine; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandin Antagonists | 1977 |
The effect of sulindac and sulindac metabolites on arachidonate-induced lethality in rabbits: effect on human, guinea pig, dog, and rat platelet activity.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Aspirin; Collagen; Dogs; Epinephrine; Guinea Pigs; Humans; Indenes; Indomethacin; Platelet Aggregation; Rats; Sulfides; Sulfones; Sulfoxides | 1977 |
Peripheral venous platelet aggregates in patients with unstable angina pectoris and acute myocardial infarction.
Topics: Acute Disease; Adenosine Diphosphate; Adult; Angina Pectoris; Aspirin; Blood Cell Count; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation | 1977 |
The effect of lithium on platelet aggregation and platelet release reaction.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Humans; Lithium; Platelet Aggregation; Serotonin; Time Factors | 1977 |
Malondialdehyde formation as an indicator of prostaglandin production by human platelets.
Topics: Adenosine Diphosphate; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Epinephrine; Humans; Indomethacin; Malonates; Malondialdehyde; Platelet Aggregation; Prostaglandins; Thrombin | 1976 |
[Studies on inhibition of platelet aggregation by carbocromen (author's transl)].
Topics: Adenosine Diphosphate; Agglutination Tests; Aspirin; Chromonar; Collagen; Coumarins; Depression, Chemical; Dose-Response Relationship, Drug; Humans; Infusions, Parenteral; Nephelometry and Turbidimetry; Pentosan Sulfuric Polyester; Platelet Adhesiveness; Platelet Aggregation; Time Factors | 1976 |
Spontaneous hyphema associated with ingestion of aspirin and ethanol.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Coagulation Tests; Blood Platelets; Collagen; Epinephrine; Ethanol; Female; Humans; Hyphema; Platelet Aggregation | 1976 |
Editorial: Much hope but little proof.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Coronary Disease; Humans; Physical Exertion; Platelet Aggregation; Thrombosis | 1976 |
Platelet aggregation by thimerosal: role of ADP and SH groups.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelet Disorders; Blood Platelets; Collagen; Ethylmercury Compounds; Humans; Platelet Aggregation; Sulfhydryl Reagents; Thimerosal; Thrombin; Tiopronin | 1976 |
Rat platelet aggregation by ATP. Aggregometrical and ultrastructural comparison with aggregations induced by ADP and collagen.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Apyrase; Aspirin; Blood Platelets; Collagen; Female; Humans; Male; Platelet Aggregation; Rats | 1976 |
Salicylate- and aspirin-induced uncoupling of oxidative phosphorylation in mitochondria isolated from the mucosal membrane of the stomach.
Topics: Adenosine Diphosphate; Animals; Aspirin; Gastric Mucosa; Microscopy, Electron; Mitochondria; Oxidative Phosphorylation; Oxygen Consumption; Salicylates; Swine; Uncoupling Agents | 1976 |
Inhibiting effect of feprazone on "in vitro" human platelet aggregation.
Topics: Adenosine Diphosphate; Anti-Inflammatory Agents; Aspirin; Collagen; Humans; In Vitro Techniques; Indomethacin; Phenylbutazone; Platelet Aggregation; Salicylates | 1976 |
Glucose-6-phosphate dehydrogenase activity in human platelets and its secretion.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Collagen; Epinephrine; Glucosephosphate Dehydrogenase; Humans; Secretory Rate | 1976 |
The influence of acetylsalicylic acid (aspirin) on gastric mucosal content of energy-rich phosphate bond.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Aspirin; Female; Gastric Mucosa; Male; Swine | 1976 |
Abnormalities of factor VIII and platelet aggregation--use of ristocetin in diagnosing the von Willebrand syndrome.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Blood Coagulation Tests; Blood Platelets; Collagen; Epinephrine; Factor VIII; Glass; Humans; Platelet Adhesiveness; Platelet Aggregation; Ristocetin; von Willebrand Diseases | 1975 |
Impaired interaction (adhesion-aggregation) of platelets with the subendothelium in storage-pool disease and after aspirin ingestion. A comparison with von Willebrand's disease.
Topics: Adenosine Diphosphate; Administration, Oral; Adolescent; Adult; Animals; Aorta, Abdominal; Aspirin; Blood Platelet Disorders; Blood Platelets; Endothelium; Humans; In Vitro Techniques; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Purpura, Thrombocytopenic; Rabbits; Syndrome; von Willebrand Diseases | 1975 |
Spontaneous platelet aggregation. Occurrence in an asymptomatic individual.
Topics: Adenosine Diphosphate; Aspirin; Depression, Chemical; Glucose Tolerance Test; Humans; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation | 1975 |
Content and thrombin-induced release of acid hydrolases in gel-filtered platelets from patients with storage pool disease.
Topics: Acetylglucosaminidase; Acid Phosphatase; Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Blood Platelet Disorders; Blood Platelets; Chromatography, Gel; Galactosidases; Glucuronidase; Humans; Hydrolases; Serotonin; Thrombin; Tritium | 1975 |
Increased platelet aggregation in early diabetus mellitus.
Topics: Adenosine Diphosphate; Administration, Oral; Aspirin; Collagen; Diabetes Mellitus; Diabetic Angiopathies; Epinephrine; Glucose; Glucose Tolerance Test; Humans; In Vitro Techniques; Platelet Adhesiveness; Platelet Aggregation; Prediabetic State; Time Factors; Tolbutamide | 1975 |
Editorial: Platelet aggregation.
Topics: Adenosine Diphosphate; Aspirin; Cerebrovascular Disorders; Coronary Disease; Glucose; Humans; Hyperlipidemias; Platelet Aggregation; Tolbutamide | 1975 |
[The effect of bencyclan on shear induced platelet aggregation (author's transl)].
Topics: Adenosine Diphosphate; Administration, Oral; Adult; Aspirin; Bencyclane; Cycloheptanes; Dose-Response Relationship, Drug; Humans; Injections, Intravenous; Kinetics; Male; Nephelometry and Turbidimetry; Platelet Aggregation; Serotonin | 1975 |
Proceedings: Effect of acetyl salicylic acid on platelet function in vivo.
Topics: Adenosine Diphosphate; Aspirin; Humans; In Vitro Techniques; Platelet Aggregation | 1975 |
Effects of suprofen, an inhibitor of prostaglandin biosynthesis, on platelet function, plasma coagulation and fibrinolysis II. In vivo experiments.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Blood Platelets; Collagen; Dogs; Fibrinolysis; Guinea Pigs; Hemostasis; Male; Phenylbutazone; Phenylpropionates; Platelet Adhesiveness; Platelet Aggregation; Prostaglandin Antagonists; Pyrimidines; Rats; Thiophenes; Time Factors; Warfarin | 1975 |
Effect of clonixin and aspirin on platelet aggregation in human volunteers.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Coagulation; Clonixin; Collagen; Epinephrine; Female; Humans; Male; Nicotinic Acids; Platelet Aggregation; Time Factors | 1976 |
The effect of thrombocytopenia on the determination of platelet aggregation.
Topics: Adenosine Diphosphate; Adult; Aspirin; Collagen; Epinephrine; Humans; Platelet Aggregation; Thrombocytopenia | 1976 |
Prostaglandin E2 potentiation of platelet aggregation induced by LASS endoperoxide: absent in storage pool disease, normal after aspirin ingestion.
Topics: Adenosine Diphosphate; Arachidonic Acids; Aspirin; Blood Platelet Disorders; Blood Platelets; Drug Synergism; Humans; Peroxides; Platelet Aggregation; Prostaglandins E | 1976 |
The influence of aspirin and indomethacin on the platelet contractile wave.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Epinephrine; Humans; In Vitro Techniques; Indomethacin; Platelet Aggregation; Prostaglandins; Thrombin | 1976 |
Suloctidil: a novel inhibitor of platelet aggregation in human beings.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Coagulation; Collagen; Dipyridamole; Dose-Response Relationship, Drug; Epinephrine; Female; Fibrinolytic Agents; Humans; Male; Platelet Adhesiveness; Platelet Aggregation; Time Factors | 1976 |
Inhibition of platelet aggregation by papaverine-like drugs: evidence for a novel mechanism of action.
Topics: Adenosine Diphosphate; Aspirin; Collagen; Epinephrine; Humans; Indomethacin; Isoproterenol; Papaverine; Phentolamine; Platelet Aggregation; Practolol; Propranolol; Tretoquinol | 1976 |
Acetylsalicylic acid inhibition of rat and human platelet aggregation. An in vitro comparative study.
Topics: Adenosine Diphosphate; Animals; Aspirin; Collagen; Epinephrine; Female; Humans; Male; Platelet Aggregation; Rats | 1976 |
Potentiation of ADP-induced aggregation in human platelet-rich plasma by 5-hydroxytryptamine and adrenaline.
Topics: Adenosine Diphosphate; Adult; Aspirin; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; Female; Humans; In Vitro Techniques; Ketanserin; Male; Platelet Aggregation; Serotonin; Yohimbine | 1992 |
Low concentrations of sodium azide specifically inhibit a thromboxane A2 pathway in human platelets.
Topics: Adenosine Diphosphate; Apyrase; Arachidonic Acid; Aspirin; Azides; Blood Platelets; Calcium; Collagen; Energy Metabolism; Enzyme Activation; Humans; Hydrogen-Ion Concentration; Myosin-Light-Chain Kinase; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Secretory Rate; Serotonin; Sodium Azide; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2 | 1992 |
Polypropylene small-diameter vascular grafts.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Vessel Prosthesis; Dipyridamole; Dogs; Foreign-Body Reaction; Microscopy, Electron; Microscopy, Electron, Scanning; Platelet Aggregation; Polyethylene Terephthalates; Polypropylenes; Polytetrafluoroethylene; Vascular Patency | 1992 |
Effect of anethole dithiolthione on human platelet aggregation.
Topics: Adenosine Diphosphate; Adult; Anethole Trithione; Arachidonic Acid; Aspirin; Butylated Hydroxytoluene; Humans; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Radioimmunoassay; Thrombin; Thromboxane B2 | 1992 |
Platelet activation and subsequent inhibition by plasmin and recombinant tissue-type plasminogen activator.
Topics: Adenosine Diphosphate; Apyrase; Aspirin; Blood Platelets; Calcimycin; Calcium; Fibrinolysin; Humans; Platelet Activation; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Recombinant Proteins; Serotonin; Streptokinase; Tissue Plasminogen Activator | 1992 |
Acute in vitro effects of ethanol on responses of platelets from cholesterol-fed and Watanabe heritable hyperlipidemic rabbits.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Cholesterol, Dietary; Collagen; Ethanol; Hyperlipidemias; Male; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Thrombin; Thromboxane A2 | 1992 |
Effects of the new antiplatelet agent 2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine on platelet aggregation and thrombosis in experimental animals.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Bridged Bicyclo Compounds; Cyclooxygenase Inhibitors; Dogs; Electroencephalography; Female; Fibrinolytic Agents; Guinea Pigs; Humans; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred ICR; Nicotinic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Inbred Strains; Respiration; Stomach Ulcer | 1992 |
Platelet activation by cross-linking HLA class I molecules and Fc receptor.
Topics: Adenosine Diphosphate; Antibodies, Monoclonal; Apyrase; Aspirin; Blood Platelets; Calcium; Cross-Linking Reagents; Cytoplasmic Granules; Histocompatibility Antigens Class I; Humans; Hydrogen-Ion Concentration; Immunoglobulin G; Inositol 1,4,5-Trisphosphate; Phosphoproteins; Platelet Activation; Platelet Aggregation; Receptors, Fc; Thromboxane A2 | 1992 |
Increased whole blood platelet aggregation in normal pregnancy can be prevented in vitro by aspirin and dazmegrel (UK38485).
Topics: Adenosine Diphosphate; Aspirin; Collagen; Epinephrine; Female; Humans; Imidazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Pregnancy; Prospective Studies; Thromboxane-A Synthase | 1992 |
Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Aspirin; beta-Thromboglobulin; Blood Platelets; Collagen; Erythrocytes; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Membrane Glycoproteins; Serotonin; Thromboxane A2; Thromboxane B2; Thromboxanes | 1991 |
Rapidity and duration of platelet suppression by enteric-coated aspirin in healthy young men.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Epinephrine; Epoprostenol; Humans; Male; Platelet Aggregation; Reference Values; Tablets, Enteric-Coated; Thromboxane A2; Time Factors | 1992 |
Effects of treatment with aspirin or aspirin/dipyridamole combination in heartworm-negative, heartworm-infected, and embolized heartworm-infected dogs.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Collagen; Dipyridamole; Dirofilariasis; Dog Diseases; Dogs; Drug Therapy, Combination; Embolism; Lung; Platelet Aggregation; Platelet Count; Serotonin | 1991 |
Effects of combination therapy with low-dose aspirin and warfarin on platelet functions after heart valve replacement.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Bleeding Time; Blood Platelets; Calcium; Collagen; Drug Therapy, Combination; Female; Heart Valve Prosthesis; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prostaglandin Endoperoxides, Synthetic; Thromboembolism; Ticlopidine; Warfarin | 1991 |
New monoclonal anti-human Fc gamma receptor II antibodies induce platelet aggregation.
Topics: Adenosine Diphosphate; Antibodies, Monoclonal; Antibody Specificity; Antigens, Differentiation; Aspirin; Blood Platelets; Blotting, Western; Calcimycin; Humans; Immunoglobulin M; In Vitro Techniques; Molecular Weight; Platelet Aggregation; Receptors, Fc; Receptors, IgG | 1991 |
Examination of the roles of glycoprotein Ib and glycoprotein IIb/IIIa in platelet deposition on an artificial surface using clinical antiplatelet agents and monoclonal antibody blockade.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Antibodies, Monoclonal; Aspirin; Blood Platelets; Humans; In Vitro Techniques; L-Lactate Dehydrogenase; Perfusion; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins | 1991 |
Platelet hypersensitivity in cholesterol-fed rabbits: enhancement of thromboxane A2-dependent and thrombin-induced, thromboxane A2-independent platelet responses.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Cholesterol; Collagen; Hypercholesterolemia; Male; Platelet Aggregation; Platelet Count; Prostaglandin Endoperoxides, Synthetic; Rabbits; Serotonin; Thrombin; Thromboxane A2; Thromboxane B2 | 1991 |
Some properties of rat platelet aggregation and effects of butylated hydroxytoluene, warfarin and aspirin.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Coagulation Factors; Butylated Hydroxytoluene; Collagen; Epinephrine; Male; Platelet Activating Factor; Platelet Aggregation; Rats; Rats, Inbred Strains; Ristocetin; Warfarin | 1991 |
Antithrombotic actions of aspirin in the horse.
Topics: Adenosine Diphosphate; Animals; Aspirin; Bleeding Time; Blood Platelets; Collagen; Horses; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 1991 |
Platelet activation by a synthetic hydrophobic polymer, polymethylmethacrylate.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Apyrase; Aspirin; Blood Platelets; Calcium; Chymotrypsin; Fibrinogen; Humans; Methylmethacrylates; Microscopy, Electron; Microscopy, Electron, Scanning; Microspheres; Molecular Sequence Data; Phosphorylation; Platelet Activation; Platelet Aggregation; Protein Kinase C; Serotonin | 1991 |
In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Drug Interactions; Female; Humans; Male; Malondialdehyde; Phthalic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Sulfonamides; Thromboxane B2 | 1991 |
Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells.
Topics: Adenosine Diphosphate; Apyrase; Aspirin; Blood Platelets; Endothelium, Vascular; Humans; In Vitro Techniques; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin | 1991 |
Comparison of in vitro platelet aggregation and its inhibition by three antithrombotic drugs between human and guinea pig.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Collagen; Dipyridamole; Guinea Pigs; Humans; Pentoxifylline; Platelet Aggregation; Platelet Aggregation Inhibitors; Species Specificity; Thrombin | 1991 |
Enhancement of platelet reactivity and modulation of eicosanoid production by intact erythrocytes. A new approach to platelet activation and recruitment.
Topics: Adenosine Diphosphate; Aspirin; Calcimycin; Collagen; Eicosanoids; Erythrocytes; Humans; Platelet Activation; Serotonin; Thrombin | 1991 |
[Clinical evaluation of platelet antagonists on the ex vivo inhibitory effects of platelet aggregation].
Topics: Adenosine Diphosphate; Aspirin; Collagen; Dose-Response Relationship, Drug; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 1991 |
Inhibitory effect of vitamin E (alpha-tocopherol) on spontaneous platelet aggregation in whole blood.
Topics: Adenosine Diphosphate; Adult; Aspirin; Creatine Kinase; Drug Synergism; Humans; In Vitro Techniques; Male; Phosphocreatine; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation Inhibitors; Verapamil; Vitamin E | 1990 |
Levamisole inhibits in vivo rat platelet aggregation by a release of prostacyclin-like factor.
Topics: Adenosine Diphosphate; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Epoprostenol; Half-Life; In Vitro Techniques; Leukocytes; Levamisole; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Thromboxane A2 | 1990 |
A new platelet function test.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Bleeding Time; Blood Specimen Collection; Calcium; Collagen; Edetic Acid; Humans; Platelet Aggregation; Platelet Count; Platelet Function Tests; Ristocetin | 1990 |
Inhibitory effects of endothelial cells and calcium channel blockers on platelet aggregation.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Aspirin; Blood Platelets; Bone Marrow Cells; Calcium Channel Blockers; Collagen; Diltiazem; Endothelium, Vascular; Epoprostenol; Fibroblasts; Humans; Nicardipine; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2; Verapamil | 1990 |
Effects of various inhibitors on platelet activation induced by TP 82, a CD 9 monoclonal antibody.
Topics: Adenosine Diphosphate; Aequorin; Amino Acid Sequence; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Dose-Response Relationship, Drug; Humans; Membrane Glycoproteins; Molecular Sequence Data; Oligopeptides; Platelet Activation; Serotonin; Tetraspanin 29; Thromboxane A2 | 1990 |
Comparison of the effects of streptokinase, t-PA and APSAC on human platelet aggregation in vitro in the absence and presence of aspirin.
Topics: Adenosine Diphosphate; Anistreplase; Aspirin; Collagen; Fibrinolytic Agents; Humans; In Vitro Techniques; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Streptokinase; Tissue Plasminogen Activator | 1990 |
Proaggregatory effect of epinephrine on rabbit platelets inhibited by ticlopidine.
Topics: Adenosine Diphosphate; Amiloride; Animals; Aspirin; Drug Interactions; Epinephrine; Hydrogen-Ion Concentration; Male; Methylamines; Monensin; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Receptors, Adrenergic, alpha; Sodium; Thromboxane A2; Ticlopidine | 1990 |
The effects of siguazodan, a selective phosphodiesterase inhibitor, on human platelet function.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Blood Platelets; Calcium; Chromatography, Ion Exchange; Collagen; Cyclic AMP; Guanidines; Humans; In Vitro Techniques; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandin Endoperoxides, Synthetic; Pyridazines | 1990 |
Inositol phospholipid metabolism in human platelets stimulated by ADP.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Calcium; Fibrinogen; Humans; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Platelet Aggregation; Thromboxane A2; Type C Phospholipases | 1990 |
Direct activation of platelets by heat is the possible trigger of the coagulopathy of heat stroke.
Topics: Adenosine Diphosphate; Adult; Aged; Aspirin; Blood Coagulation Disorders; Cells, Cultured; Female; Heat Exhaustion; Hot Temperature; Humans; Male; Middle Aged; Platelet Aggregation | 1990 |
Stimulus-response coupling in human platelets activated by monoclonal antibodies to the CD9 antigen, a 24 kDa surface-membrane glycoprotein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Aspirin; Blood Platelets; Calcium; Collagen; Humans; Hydrogen-Ion Concentration; Immunoglobulin Fab Fragments; Isoquinolines; Membrane Glycoproteins; Phosphoproteins; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Kinase C; Serotonin; Signal Transduction; Tetraspanin 29; Thromboxane A2 | 1990 |
Dietary polyenoic fatty acids change the response of cat blood platelets to inductions of aggregation by ADP.
Topics: Adenosine Diphosphate; Aging; Animals; Aspirin; Blood Platelets; Cats; Dietary Fats, Unsaturated; Fatty Acids, Unsaturated; Female; Male; Platelet Aggregation; Platelet Aggregation Inhibitors | 1990 |
Attempts to standardize platelet aggregation measurements: simplified screening tests.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aspirin; Blood Coagulation Disorders; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Microcomputers; Middle Aged; Platelet Aggregation; Platelet Function Tests; Reference Standards | 1990 |
Asialo von Willebrand factor binding to and aggregation of platelets: effects of inhibitors of platelet metabolism and function.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Adenosine Triphosphate; Antibodies, Monoclonal; Asialoglycoproteins; Aspirin; Binding Sites; Blood Platelets; Humans; Platelet Aggregation; Platelet Membrane Glycoproteins; von Willebrand Factor | 1987 |
Tissue plasminogen activator promotes platelet disaggregation in plasma.
Topics: Adenosine Diphosphate; alpha-2-Antiplasmin; Aspirin; Blood Platelets; Fibrin Fibrinogen Degradation Products; Fibrinogen; Humans; Kinetics; Platelet Aggregation; Platelet Membrane Glycoproteins; Tissue Plasminogen Activator | 1987 |
The PGI2-analogue iloprost and the TXA2-receptor antagonist sulotroban synergistically inhibit TXA2-dependent platelet activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Drug Synergism; Epoprostenol; Fatty Acids, Unsaturated; Humans; Hydrazines; Iloprost; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Prostaglandins, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides | 1988 |
Iron chelators inhibit human platelet aggregation, thromboxane A2 synthesis and lipoxygenase activity.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Deferiprone; Deferoxamine; Epinephrine; Humans; Iron; Iron Chelating Agents; Lipoxygenase; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyridones; Thromboxane A2 | 1989 |
[Platelet aggregation in asthma].
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Asthma; Bronchial Provocation Tests; Collagen; Drug Hypersensitivity; Epinephrine; Humans; Platelet Aggregation | 1989 |
Correlation between template bleeding times and spontaneous bleeding during treatment of acute myocardial infarction with recombinant tissue-type plasminogen activator.
Topics: Adenosine Diphosphate; Aspirin; Bleeding Time; Emergencies; Fibrin Fibrinogen Degradation Products; Hematocrit; Hemorrhage; Hemostasis; Humans; Myocardial Infarction; Platelet Aggregation; Recombinant Proteins; Time Factors; Tissue Plasminogen Activator | 1989 |
[Effects of low-dose acetylsalicylic acid on thrombocytes in health subjects and in patients with coronary heart disease].
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Coronary Disease; Dose-Response Relationship, Drug; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Thromboxane B2; Time Factors | 1989 |
Increased platelet aggregation and intracellular calcium in hypertensive patients: effects of cyclo-oxygenase blockade.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcium; Cyclooxygenase Inhibitors; Female; Humans; Hypertension; Male; Middle Aged; Platelet Aggregation; Thromboxane A2 | 1989 |
Effect of aspirin on platelet-von Willebrand factor surface expression on thrombin and ADP-stimulated platelets.
Topics: Adenosine Diphosphate; Aspirin; beta-Thromboglobulin; Blood Platelets; Cytochalasin D; Cytoplasmic Granules; Humans; In Vitro Techniques; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombin; von Willebrand Factor | 1989 |
Inhibition of fibrinogen binding to human platelets by blockage of Na+/H+ exchange.
Topics: Adenosine Diphosphate; Amiloride; Aspirin; Blood Platelets; Carrier Proteins; Fibrinogen; Humans; In Vitro Techniques; Kinetics; Platelet Membrane Glycoproteins; Sodium-Hydrogen Exchangers | 1989 |
Platelet aggregation in the Asian elephant is not dependent on thromboxane B2 production.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Elephants; Female; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Verapamil | 1989 |
Induction of platelet aggregation in vitro by microbubbles of nitrogen.
Topics: Adenosine Diphosphate; Aspirin; Drug Synergism; Epinephrine; Gases; Humans; In Vitro Techniques; Indomethacin; Ketanserin; Nitrogen; Platelet Aggregation; Serotonin; Yohimbine | 1989 |
Effect of low dose acetylsalicylic acid upon plasma thromboxane B2 levels and platelet aggregation in ischemic stroke patients.
Topics: Adenosine Diphosphate; Aged; Aspirin; Brain Ischemia; Cerebrovascular Disorders; Female; Humans; Male; Middle Aged; Platelet Aggregation; Random Allocation; Thromboxane B2 | 1989 |
Individually controlled aspirin in the long-term treatment of patients with chronic arterial diseases.
Topics: Adenosine Diphosphate; Arteriosclerosis; Aspirin; Blood Platelets; Brain Ischemia; Coronary Disease; Female; Humans; Male; Malondialdehyde; Middle Aged; Platelet Aggregation | 1989 |
Evidence that the phosphatidylinositol cycle is linked to cell motility.
Topics: Actins; Adenosine Diphosphate; Aspirin; Blood Platelets; Cell Movement; Humans; Kinetics; Lipids; Macromolecular Substances; Neomycin; Phosphatidylinositols; Thrombin | 1988 |
[Ditazol in the therapy of ischemic cerebrovascular diseases. Clinical results and laboratory experiments (22-to-34-month clinical follow-up)].
Topics: Adenosine Diphosphate; Adult; Aged; Aspirin; Brain Ischemia; Collagen; Epinephrine; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Oxazoles; Platelet Aggregation | 1985 |
[Ischemic cerebrovascular disease: treatment with various anti-platelet aggregation drugs. Clinical follow-up of 80 patients (22-34 months)].
Topics: Adenosine Diphosphate; Aspirin; Brain Ischemia; Dipyridamole; Female; Humans; Isoxsuprine; Male; Oxazoles; Platelet Aggregation; Recurrence | 1985 |
Lymphocyte aggregation in response to adrenergic stimulation.
Topics: Adenosine Diphosphate; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Cell Aggregation; Citrates; Citric Acid; Dyspnea; Female; Humans; Leukapheresis; Leukemia, Lymphoid; Lymphocytes; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Receptors, Adrenergic, beta | 1988 |
Phospholipase C from clostridium perfringens induces human platelet aggregation in plasma.
Topics: Adenosine Diphosphate; Adult; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Clostridium perfringens; Female; Humans; In Vitro Techniques; Male; Platelet Aggregation; Type C Phospholipases | 1988 |
Hepatic metabolic alterations in rats treated with low-dose endotoxin and aspirin: an animal model of Reye's syndrome.
Topics: Acyl Coenzyme A; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aspirin; Disease Models, Animal; Drug Interactions; Endotoxins; Energy Metabolism; Humans; Ketone Bodies; Liver; Male; Rats; Rats, Inbred Strains; Reye Syndrome | 1989 |
Specific correction of impaired acid hydrolase secretion in storage pool-deficient platelets by adenosine diphosphate.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; beta-N-Acetylhexosaminidases; Blood Platelet Disorders; Blood Platelets; Calcimycin; Calcium; Dose-Response Relationship, Drug; Epinephrine; Formaldehyde; Humans; Hydrolases; Platelet Storage Pool Deficiency; Thrombin | 1988 |
Mechanism of the inhibition of platelet aggregation produced by prostaglandin F2 alpha.
Topics: Adenosine Diphosphate; Aspirin; Cyclic AMP; Cyclic GMP; Dinoprost; Humans; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins F; Prostaglandins H; Prostaglandins, Synthetic; Thrombin | 1985 |
Thromboxane- and ADP-independent aggregation and exposure of fibrinogen receptors on platelets from patients with familial hypercholesterolemia.
Topics: Adenosine Diphosphate; Adolescent; Adult; Apyrase; Aspirin; Child; Female; Humans; Hyperlipoproteinemia Type II; Male; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Thromboxanes | 1985 |
Sub-aggregatory doses of catecholamines prevent prostacyclin-induced inhibition of platelet aggregation.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Catecholamines; Cyclic AMP; Epinephrine; Epoprostenol; Humans; In Vitro Techniques; Phentolamine; Platelet Aggregation | 1985 |
Biochemical background of the development of gastric mucosal damage in pylorus-ligated plus aspirin-treated rats.
Topics: Absorption; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Aspirin; Cyclic AMP; Energy Metabolism; Female; Gastric Emptying; Gastric Juice; Gastric Mucosa; Hydrogen-Ion Concentration; Lactates; Ligation; Male; Rats; Stomach Ulcer | 1986 |
Separable function of platelet release reaction and clot retraction.
Topics: Actins; Adenosine Diphosphate; Amiloride; Aspirin; Blood Platelets; Clot Retraction; Cytochalasin B; Humans; Protons; Serotonin; Sodium; Tetradecanoylphorbol Acetate | 1986 |
Pathways responsible for platelet hypersensitivity in rats with diabetes. I. Streptozocin-induced diabetes.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Creatine Kinase; Diabetes Mellitus; In Vitro Techniques; Male; Phosphocreatine; Platelet Adhesiveness; Platelet Aggregation; Rats; Rats, Inbred Strains; Serotonin; Thrombin | 1986 |
Effect of common agonists on cytoplasmic ionized calcium concentration in platelets. Measurement with 2-methyl-6-methoxy 8-nitroquinoline (quin2) and aequorin.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aequorin; Aminoquinolines; Aspirin; Blood Platelets; Calcium; Collagen; Dose-Response Relationship, Drug; Egtazic Acid; Epinephrine; Humans; Platelet Aggregation; Thrombin | 1986 |
The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation in man and the rat.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Creatine Kinase; Dose-Response Relationship, Drug; Humans; Imidazoles; In Vitro Techniques; Male; Phosphocreatine; Platelet Aggregation; Prostaglandin Endoperoxides; Rats; Rats, Inbred Strains; Species Specificity; Thromboxane A2; Thromboxane B2 | 1986 |
Relationship between structure and activity of aspirin-related compounds on the inhibition of in vitro platelet aggregation.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Drug Interactions; Humans; In Vitro Techniques; Platelet Aggregation; Salicylates; Structure-Activity Relationship | 1986 |
Effects of acetylsalicylic acid on platelet aggregation in male and female whole blood: an in vitro study.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Male; Platelet Aggregation; Sex Factors | 1986 |
Miconazole inhibition of platelet aggregation by inhibiting cyclooxygenase.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Cyclooxygenase Inhibitors; Humans; Kinetics; Malondialdehyde; Miconazole; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases | 1986 |
ATP-secretion occurs as an initial response in collagen induced platelet activation.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Edetic Acid; Egtazic Acid; Humans; Kinetics; Platelet Aggregation; Theophylline; Verapamil; Yohimbine | 1986 |
Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man.
Topics: Adenosine Diphosphate; Adolescent; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Thromboxane B2; Thromboxanes | 1986 |
Antagonists of PAF-acether do not suppress thrombin-induced aggregation of ADP-deprived and aspirin-treated human platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Blood Platelets; Crotalid Venoms; Cyclooxygenase Inhibitors; Diterpenes; Ginkgolides; Glyceryl Ethers; Humans; Lactones; Lectins, C-Type; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Pyridines; Thiazoles; Thrombin | 1987 |
Direct platelet-fibrin interaction that does not require platelet activation.
Topics: Adenosine Diphosphate; Alprostadil; Aspirin; Blood Platelets; Egtazic Acid; Fibrin; HEPES; Humans; Hydrogen-Ion Concentration; Kinetics; Nephelometry and Turbidimetry; Oligopeptides; Platelet Aggregation; Polymers; Serotonin | 1987 |
Sex-related differences in platelet aggregation in native whole blood.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Female; Fibrinogen; Humans; Male; Platelet Aggregation; Sex Factors; Thrombin | 1987 |
Exchange of cyclooxygenase dependent metabolites between vessel wall and platelets in arterial thrombosis.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Epoprostenol; Imidazoles; Male; Mesenteric Arteries; Platelet Aggregation; Propionates; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Thrombosis; Thromboxane A2; Tranylcypromine | 1988 |
Combined arachidonic acid and ADP platelet inhibition maximizes patency of small-diameter vascular grafts.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Vessel Prosthesis; Carotid Arteries; Dogs; Femoral Artery; Platelet Aggregation; Polytetrafluoroethylene; Thromboxane B2; Ticlopidine; Vascular Patency | 1988 |
Studies on the effect of long-term use of low dose aspirin in Kawasaki disease.
Topics: Adenosine Diphosphate; Aspirin; Child, Preschool; Collagen; Dose-Response Relationship, Drug; Epinephrine; Epoprostenol; Female; Humans; Male; Mucocutaneous Lymph Node Syndrome; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins; Prostaglandins F; Thromboxane A2; Thromboxane B2; Time Factors | 1988 |
Dipyridamole and aspirin in arteriosclerosis obliterans of the lower limbs.
Topics: Adenosine Diphosphate; Adult; Arteriosclerosis Obliterans; Aspirin; Dipyridamole; Drug Therapy, Combination; Epoprostenol; Female; Humans; Leg; Male; Middle Aged; Platelet Aggregation | 1985 |
Individually controlled acetylsalicyclic acid (ASA) in the long-term treatment of patients with arteriosclerosis.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Arteriosclerosis; Aspirin; Biomarkers; Humans; Hydroxyeicosatetraenoic Acids; Malondialdehyde; Platelet Aggregation; Reference Values | 1988 |
Shear-induced platelet aggregation can be mediated by vWF released from platelets, as well as by exogenous large or unusually large vWF multimers, requires adenosine diphosphate, and is resistant to aspirin.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Humans; Platelet Aggregation; Stress, Mechanical; von Willebrand Factor | 1988 |
Effect of low-dose aspirin treatment on human platelet aggregation.
Topics: Adenosine Diphosphate; Adult; Aspirin; Collagen; Female; Humans; Male; Platelet Aggregation | 1988 |
Inhibitory effect of acetylsalicylic acid on platelet function in patients with completed stroke or reversible ischemic neurologic deficit.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cerebrovascular Disorders; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation; Thromboxane B2 | 1988 |
Effect of curcumin on platelet aggregation and vascular prostacyclin synthesis.
Topics: Adenosine Diphosphate; Animals; Aorta, Thoracic; Aspirin; Catechols; Collagen; Curcumin; Epinephrine; Epoprostenol; In Vitro Techniques; Macaca mulatta; Muscle, Smooth, Vascular; Platelet Aggregation; Rats | 1986 |
Room temperature ADP induced first stage hyperaggregation of human blood platelets: a previously undescribed phenomenon and its relationship to spontaneous cold induced platelet aggregation.
Topics: Adenosine Diphosphate; Aspirin; Cold Temperature; Dose-Response Relationship, Drug; Humans; Platelet Aggregation; Temperature | 1987 |
Platelet function in pregnancy induced hypertension following treatment with labetalol and low dose aspirin.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Labetalol; Platelet Aggregation; Platelet Count; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Trimester, Third | 1987 |
Aspirin effect on platelet antiplasmins release.
Topics: Adenosine Diphosphate; alpha-2-Antiplasmin; Aspirin; Blood Platelets; Collagen; Fibrinolysis; Humans; In Vitro Techniques; Serum Globulins | 1987 |
Comparison of the effect of acetylsalicylic acid on platelet function in male and female patients with ischemic stroke.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Brain Ischemia; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Salicylates; Salicylic Acid; Sex Factors; Thromboxane B2 | 1987 |
Inhibition of platelet 5-HT secretion and of 5-HT induced vasoconstriction by paracetamol.
Topics: Acetaminophen; Adenosine Diphosphate; Aspirin; Blood Platelets; Humans; In Vitro Techniques; Platelet Aggregation; Salicylates; Salicylic Acid; Serotonin; Thromboxane A2; Vasoconstriction | 1987 |
Tumour-cell-induced platelet aggregation: studies with cloned metastatic and non-metastatic variants.
Topics: Adenosine Diphosphate; Animals; Aspirin; Cell Line; Creatine Kinase; Heparin; Humans; Mammary Neoplasms, Experimental; Melanoma, Experimental; Mice; Neoplasm Metastasis; Platelet Aggregation | 1987 |
Contribution of ADP to the amplification of primary platelet aggregation by platelet activating factor (PAF): modulatory role of aspirin.
Topics: Adenosine Diphosphate; Aspirin; Creatine Kinase; Drug Interactions; Humans; Kinetics; Phosphocreatine; Platelet Activating Factor; Platelet Aggregation | 1986 |
Collagen increases cytoplasmic free calcium in human platelets.
Topics: Adenosine Diphosphate; Aminoquinolines; Apyrase; Aspirin; Blood Platelets; Calcium; Collagen; Cytoplasm; Fluorescent Dyes; Humans; Kinetics; Platelet Aggregation | 1986 |
Increasing platelet aggregability after venepuncture is platelet, not plasma derived.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Bloodletting; Carbonic Acid; Evaluation Studies as Topic; Female; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Plasma; Platelet Aggregation; Temperature; Time Factors | 1986 |
[Importance of prostaglandins and cyclic nucleotides in altering thrombocyte aggregation induced by thyroxine].
Topics: Adenosine Diphosphate; Animals; Aspirin; Drug Interactions; Female; Indomethacin; Male; Nucleotides, Cyclic; Platelet Aggregation; Prostaglandins, Synthetic; Rabbits; Serotonin; Thyroxine; Time Factors | 1986 |
In vitro comparison of antiplatelet effects of beta-lactam penicillins.
Topics: Adenosine Diphosphate; Aspirin; Carbenicillin; Collagen; Dose-Response Relationship, Drug; Epinephrine; Humans; Penicillin G; Penicillins; Platelet Aggregation; Thrombin | 1986 |
Heparin-induced thrombocytopenia: further studies of the effects of heparin-dependent antibodies on platelets.
Topics: Adenosine Diphosphate; Antibodies; Aspirin; Bernard-Soulier Syndrome; Dipyridamole; Heparin; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandin Antagonists; Prostaglandins E; Thrombasthenia; Thrombocytopenia | 1986 |
Effects of oral diltiazem on platelet function: alone and in combination with "low dose" aspirin.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Administration, Oral; Aspirin; Bleeding Time; Blood Platelets; Diltiazem; Epinephrine; Humans; Male; Platelet Aggregation; Thromboxane A2 | 1986 |
Adenosine diphosphate (ADP)-induced alpha-granules release from platelets of native whole blood is reduced by ticlopidine but not by aspirin or dipyridamole.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Cytoplasmic Granules; Dipyridamole; Female; Humans; Kinetics; Male; Ticlopidine | 1986 |
Ultrastructural evidence for extravascular platelet recruitment in the lung upon intravenous injection of platelet-activating factor (PAF-acether) to guinea-pigs.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Bronchi; Constriction, Pathologic; Epoprostenol; Female; Guinea Pigs; Lung; Microscopy, Electron; Neutrophils; Platelet Activating Factor; Platelet Aggregation; Time Factors | 1985 |
The influence of molsidomine and its active metabolite SIN-1 on fibrinolysis and platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Aspirin; Cats; Epoprostenol; Female; Fibrinolysis; Humans; In Vitro Techniques; Male; Molsidomine; Oxadiazoles; Platelet Aggregation; Rabbits; Sydnones | 1985 |
Prostaglandins and human platelet aggregation. Implications for the anti-aggregating activity of thromboxane-synthase inhibitors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Dinoprost; Dinoprostone; Drug Synergism; Humans; Imidazoles; Oxidoreductases; Platelet Aggregation; Prostaglandin D2; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Prostaglandins D; Prostaglandins E; Prostaglandins F; Prostanoic Acids; Thromboxane B2; Thromboxane-A Synthase | 1985 |
The tachyphylactic effect of arachidonic acid on in-vivo ADP induced arterial platelet thrombosis.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Coagulation; Drug Synergism; Rats; Thrombosis | 1985 |
Long-term ultra-low-dose aspirin therapy and platelet function.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Bleeding Time; Collagen; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Male; Platelet Aggregation; Thromboxane B2; Thromboxanes; Time Factors | 1985 |
[Effect of various stimulators on cyclooxygenase activity, platelet aggregation and TxB2 synthesis after using a platelet inhibitor (Aspro Clear) in vivo and in vitro].
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Collagen; Drug Synergism; Epinephrine; Female; Humans; In Vitro Techniques; Male; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 1985 |
Platelet aggregation in whole blood: the role of thromboxane A2 and adenosine diphosphate.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenosine Diphosphate; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Cyclooxygenase Inhibitors; Epinephrine; Flurbiprofen; Humans; Imidazoles; In Vitro Techniques; Lipoxygenase Inhibitors; Platelet Aggregation; Pyrazoles; Thrombin; Thromboxane A2; Thromboxane-A Synthase | 1985 |
Fibrinogen binding to human blood platelets: effect of gamma chain carboxyterminal structure and length.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Aspirin; Blood Platelets; Fibrinogen; Humans; Macromolecular Substances; Platelet Aggregation; Protein Binding; Structure-Activity Relationship; Time Factors | 1986 |
Evidence that the rat is not an appropriate model to study the role of prostaglandins in normal or abnormal platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Blood Pressure; Disease Models, Animal; Epinephrine; Humans; Hypertension; Kinetics; L-Lactate Dehydrogenase; Platelet Aggregation; Prostaglandins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Serotonin; Species Specificity; Thrombin | 1986 |
Inhibition of platelet aggregation and thromboxane B2 production during aspirin treatment: dependence on the dose of the aggregating agent.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Male; Platelet Aggregation; Thromboxane B2; Thromboxanes | 1985 |
Antihemostatic and antithrombotic effects of capsaicin in comparison with aspirin and indomethacin.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Capsaicin; Hemostasis; Indomethacin; Mice; Mice, Inbred ICR; Platelet Aggregation; Thromboembolism; Thrombosis | 1985 |
Interactions between sodium salicylate and acetyl salicylic acid evaluated using ADP induced platelet aggregation and bleeding time.
Topics: Adenosine Diphosphate; Adult; Aspirin; Bleeding Time; Blood Coagulation; Drug Interactions; Fibrinolytic Agents; Humans; Male; Platelet Aggregation; Sodium Salicylate | 1985 |
[Anti-platelet actions of salicylates: in vivo, ex vivo and in vitro effects of choline salicylate].
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Calcium; Choline; Drug Combinations; In Vitro Techniques; Male; Mice; Platelet Aggregation; Respiration; Salicylates; Shock, Septic; Sodium Salicylate | 1985 |
Effect of cilostazol on platelet aggregation and experimental thrombosis.
Topics: Adenosine Diphosphate; Animals; Aspirin; Azoles; Cilostazol; Dogs; Fibrinolytic Agents; Humans; In Vitro Techniques; Mice; Platelet Aggregation; Rabbits; Tetrazoles; Thrombosis; Vasodilator Agents | 1985 |
Responses to adenosine diphosphate in human platelets loaded with the fluorescent calcium indicator quin2.
Topics: Adenosine Diphosphate; Aminoquinolines; Aspirin; Blood Platelets; Calcium; Calcium Channel Blockers; Ethers; Fluorescent Dyes; Humans; In Vitro Techniques; Ionomycin; Ionophores; Microscopy, Electron, Scanning; Platelet Aggregation; Potassium | 1985 |
Impact of aspirin and chlorthalidone on the pharmacodynamics of oral anticoagulant drugs in man.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Anticoagulants; Aspirin; Blood Coagulation Tests; Blood Platelets; Chlorthalidone; Collagen; Dicumarol; Epinephrine; Hematocrit; Hemorrhage; Humans; Male; Metabolism; Platelet Adhesiveness; Prothrombin Time; Sodium; Warfarin | 1971 |
Platelet function: a guide to platelet membrane structure.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Cell Membrane; Cell Membrane Permeability; Cocaine; Erythrocytes; Glass; Glycosaminoglycans; Hemolysis; Heparin Antagonists; Latex; Microspheres; Osmosis; Phospholipids; Platelet Adhesiveness; Staining and Labeling | 1970 |
Human platelet contractile proteins: location, properties, and function.
Topics: Adenosine Diphosphate; Amino Acids; Antigen-Antibody Complex; Aspirin; Blood Platelets; Blood Proteins; Cell Membrane; Clot Retraction; Edetic Acid; Histocytochemistry; Humans; Immune Sera; Immunochemistry; Immunodiffusion; Leucine; Microscopy, Electron; Myosins; Peroxidases; Plant Extracts; Potassium Chloride; Pronase; Pseudopodia; Ruthenium; Staining and Labeling; Thrombin; Tritium; Viscosity | 1971 |
Spontaneous aggregation of blood platelets as a cause of idiopothic thrombosis and recurrent painful toes and fingers.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Blood Platelet Disorders; Coumarins; Fingers; Humans; Male; Middle Aged; Pain; Serotonin; Thrombophlebitis; Toes | 1971 |
Platelet membrane mucopolysaccharides: some relevant observations.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation Tests; Blood Platelets; Cell Membrane; Chromatography, Gel; Erythrocytes; Glycoproteins; Glycosaminoglycans; Heparin; Humans; Microscopy, Electron; Neuraminidase; Phospholipids; Staining and Labeling | 1972 |
Enhanced platelet function in glomerular renal disease.
Topics: Adenosine Diphosphate; Adolescent; Aspirin; Beta-Globulins; Blood Cell Count; Blood Platelets; Child; Child, Preschool; Chromatography, Gel; Collagen; Female; Fibrinogen; Glomerulonephritis; Hematocrit; Humans; Immunoglobulin G; Male; Nephrotic Syndrome; Proteinuria; Serum Albumin | 1973 |
Influence of cytostatics on aggregation and adenine nucleotides of platelets.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Amidines; Antineoplastic Agents; Aspirin; Bleomycin; Blood Platelets; Cell Membrane; Cyclophosphamide; Drug Therapy, Combination; Fluorouracil; Glyoxal; Humans; Hydrazones; Methotrexate; Neoplasms; Platelet Adhesiveness; Triaziquone; Vinca Alkaloids | 1972 |
Vascular reactions to laser in vivo.
Topics: Adenosine Diphosphate; Animals; Arteries; Aspirin; Buffers; Chiroptera; Congo Red; Endothelium; Erythrocytes; Lasers; Perfusion; Platelet Aggregation; Regional Blood Flow; Staining and Labeling; Wings, Animal | 1974 |
Willebrand factor and ristocetin. I. Mechanism of rustocetin-induced platelet aggregation.
Topics: Adenosine Diphosphate; Albumins; Aspirin; Carbon Radioisotopes; Chromatography, Gel; Dose-Response Relationship, Drug; Factor VIII; Fibrinogen; gamma-Globulins; Hemophilia A; Humans; Platelet Adhesiveness; Platelet Aggregation; Ristocetin; Serotonin; von Willebrand Diseases | 1974 |
A method for the measurement of platelet adhesiveness by use of dialysis membranes in a test-cell.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Cell Count; Edetic Acid; Female; Hematocrit; Heparin; Humans; Kidneys, Artificial; Male; Membranes, Artificial; Methods; Platelet Adhesiveness | 1973 |
Thrombocytopathia with abnormalities in platelet release reaction. Some evidence for platelet factor 4 deficiency.
Topics: Acid Phosphatase; Adenosine Diphosphate; Aged; Aspirin; Blood Coagulation Factors; Blood Coagulation Tests; Blood Platelet Disorders; Collagen; Epinephrine; Fibrinogen; Glucuronidase; Heparin; Humans; Male; Platelet Adhesiveness; Thrombin | 1973 |
Arachidonic acid-induced human platelet aggregation and prostaglandin formation.
Topics: Adenosine; Adenosine Diphosphate; Animals; Arachidonic Acids; Aspirin; Blood Platelets; Carbon Radioisotopes; Chromatography, Thin Layer; Collagen; Depression, Chemical; Dose-Response Relationship, Drug; Epinephrine; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Naphthols; Photometry; Platelet Adhesiveness; Prostaglandin Antagonists; Prostaglandins; Rabbits; Radioimmunoassay; Stimulation, Chemical | 1973 |
[Semiautomatic study of platelet aggregation].
Topics: Adenosine Diphosphate; Aspirin; Automation; Epinephrine; Humans; Methods; Platelet Adhesiveness; von Willebrand Diseases | 1972 |
Von Willebrand's disease in Italy. A study of 13 families from a small area in the province of Vicenza.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aged; Aspirin; Blood Coagulation Tests; Blood Platelets; Child; Child, Preschool; Clot Retraction; Epinephrine; Female; Humans; Italy; Male; Middle Aged; Pedigree; Platelet Adhesiveness; von Willebrand Diseases | 1974 |
Oxidative phosphorylation and respiration by rat liver mitochondria from aspirin-treated rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Aspirin; Diet; Glucose; Ketoglutaric Acids; Kinetics; Lactates; Male; Mitochondria, Liver; Oxidative Phosphorylation; Oxygen; Oxygen Consumption; Pyruvates; Rats; Succinates | 1972 |
Influence of metabolic inhibitors on ATP level and ATP-ase activity in blood platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Aspirin; Azides; Blood Platelets; Chromatography, Thin Layer; Clot Retraction; Depression, Chemical; Dinitrophenols; Dose-Response Relationship, Drug; Fluorides; Glycolysis; Humans; In Vitro Techniques; Iodoacetates; Oxidative Phosphorylation; Oxygen Consumption; Platelet Adhesiveness; Sodium; Thrombin | 1972 |
Human platelet clumping by bovine fibrinogen.
Topics: Adenosine; Adenosine Diphosphate; Afibrinogenemia; Animals; Aspirin; Blood Platelets; Cattle; Chromatography, Gel; Depression, Chemical; Edetic Acid; Fibrinogen; Fibrinolysin; Hot Temperature; Humans; Male; Plasma; Platelet Adhesiveness | 1972 |
Blood and neoplastic diseases. Haemostasis, haemorrhage, and thrombosis.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Blood Coagulation Factors; Blood Platelets; Blood Vessels; Dextrans; Disseminated Intravascular Coagulation; Fibrinolysin; Fibrinolysis; Hemorrhage; Hemostasis; Humans; Platelet Adhesiveness; Snakes; Thrombosis; Venoms | 1974 |
Human platelet collagenase.
Topics: Acid Phosphatase; Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Blood Proteins; Blood Viscosity; Buffers; Carbon Radioisotopes; Chromatography, Gel; Cold Temperature; Collagen; Edetic Acid; Electrophoresis, Disc; Electrophoresis, Polyacrylamide Gel; Glucuronidase; Guinea Pigs; Humans; Microbial Collagenase; Nucleotidases; Platelet Adhesiveness; Serotonin; Ultracentrifugation | 1974 |
Methods for the separation of platelets from plasma. A comparison of functional and morphological integrity.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Blood Coagulation Factors; Blood Platelets; Cell Separation; Centrifugation, Density Gradient; Chromatography, Gel; Collagen; Humans; Luminescent Measurements; Methods; Microscopy, Electron; Phosphoric Monoester Hydrolases; Platelet Adhesiveness; Prostaglandins; Serum Albumin, Bovine; Venoms | 1974 |
Platelet retention in glass bead columns: further evidence for the importance of ADP.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Aspirin; Blood Platelet Disorders; Carbon Radioisotopes; Creatine Kinase; Glass; Humans; Leukemia; Lymphoma; Phosphoric Monoester Hydrolases; Platelet Adhesiveness; Platelet Aggregation; Serotonin; Thrombocytopenia; von Willebrand Diseases | 1974 |
Inhibition of platelet aggregation by 2-(p-chlorophenyl)-4-thiazoleacrylic acid (Wy-23,049)--comparison with acetylsalicylic acid.
Topics: Acrylates; Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Chlorobenzenes; Collagen; Cyclic AMP; Humans; In Vitro Techniques; Indomethacin; Lysine; Platelet Adhesiveness; Platelet Aggregation; Polymers; Prostaglandins; Rats; Rats, Inbred Strains; Thiazoles; Time Factors | 1974 |
The susceptibility of the fetus and child to chemical pollutants. Special susceptibility of the fetal and neonatal hematopoietic system to chemical pollutants including drugs administered to the mother.
Topics: Abnormalities, Drug-Induced; Adenosine Diphosphate; Age Factors; Aspirin; Blood Platelets; Environmental Pollutants; Erythrocytes; Female; Fetus; Gestational Age; Hematopoietic System; Humans; Infant, Newborn; Jaundice, Neonatal; Light; Maternal-Fetal Exchange; Meperidine; Phototherapy; Platelet Adhesiveness; Pregnancy; Promethazine | 1974 |
Incorporation of carbohydrate into protein of human platelets.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Blood Proteins; Carbon Radioisotopes; Concanavalin A; Cyanides; Fluorides; Glucosamine; Glycoproteins; Humans; Kinetics; Mannose; Prostaglandins; Puromycin; Thrombin; Time Factors | 1974 |
Decreased ATP, ADP and serotonin in young platelets of fawn-hooded rats with storage pool disease.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aspirin; Blood Platelet Disorders; Blood Platelets; Hemorrhagic Disorders; Platelet Adhesiveness; Rats; Rats, Inbred Strains; Serotonin; Thrombocytopenia; Time Factors | 1974 |
Alterations in platelet aggregation associated with adjuvant arthritis in rats.
Topics: Adenosine Diphosphate; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Collagen; Disease Models, Animal; Female; Fibrinogen; Indomethacin; Mycobacterium; Phenylbutazone; Platelet Adhesiveness; Platelet Aggregation; Rats; Time Factors | 1974 |
Essential thrombocythaemia and peripheral gangrene.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Cell Count; Collagen; Gangrene; Humans; Male; Middle Aged; Phosphorus Radioisotopes; Platelet Aggregation; Thrombocythemia, Essential; Toes | 1974 |
The effect of acetylsalicylic acid on platelet adhesion in the injured abdominal aorta.
Topics: Adenosine Diphosphate; Animals; Aorta; Aorta, Abdominal; Aspirin; In Vitro Techniques; Leukocytes; Microscopy, Electron, Scanning; Platelet Adhesiveness; Rabbits | 1972 |
Qualitative platelet disorders: classification and pathogenesis.
Topics: Adenosine Diphosphate; Aspirin; Blood Cell Count; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets; Clot Retraction; Collagen; Epinephrine; Humans; Microscopy, Electron; Platelet Adhesiveness; Prothrombin; Thrombin | 1972 |
Platelet function abnormalities in the myeloproliferative disorders.
Topics: Adenosine Diphosphate; Adult; Aged; Aspirin; Blood Cell Count; Blood Platelets; Collagen; Epinephrine; Female; Humans; Leukemia, Myeloid; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Polycythemia Vera; Prothrombin Time; Serotonin; Stimulation, Chemical; Thrombocytopenia | 1974 |
Direct assessment of platelet adhesion to glass: a study of the forces of interaction and the effects of plasma and serum factors, platelet function, and modification of the glass surface.
Topics: Adenosine Diphosphate; Adsorption; Anticoagulants; Aspirin; Blood Coagulation; Blood Coagulation Factors; Blood Coagulation Tests; Blood Group Incompatibility; Calcium; Fibrinogen; Glass; Hemophilia A; Humans; Magnesium; Platelet Adhesiveness; Polyethylenes; Temperature; Thrombin; von Willebrand Diseases | 1972 |
Abnormalities in platelet function due to defects in the release reaction.
Topics: Adenine; Adenosine Diphosphate; Aspirin; Blood Coagulation; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets; Collagen; Electrophoresis; Epinephrine; Glass; Humans; Kaolin; Lipoproteins; Platelet Adhesiveness; Serotonin; Tritium; von Willebrand Diseases | 1972 |
Development of aspirin hydrolase in fetal, newborn and adult tissues.
Topics: Abnormalities, Drug-Induced; Adenosine Diphosphate; Age Factors; Animals; Animals, Newborn; Aspirin; Biotransformation; Female; Fetus; Gastrointestinal Hemorrhage; Hydrolases; Hydrolysis; Intestine, Small; Kidney; Liver; Pregnancy; Rabbits; Stomach | 1973 |
Thrombopathy. Identification and distribution.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation Factors; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets; Diagnosis, Differential; Epinephrine; Factor VIII; Female; Hemorrhage; Hemostasis; Humans; Platelet Adhesiveness; Prothrombin Time; Retrospective Studies; von Willebrand Diseases | 1974 |
Platelet antiheparin activity: storage site and release mechanism.
Topics: Acid Phosphatase; Adenine Nucleotides; Adenosine Diphosphate; Albinism; Aspirin; Blood Cell Count; Blood Platelet Disorders; Blood Platelets; Brain; Carbon Radioisotopes; Collagen; Factor X; Galactosidases; Glucuronidase; Heparin; Humans; Lysosomes; Microscopy, Phase-Contrast; Platelet Adhesiveness; Serotonin; Thrombin; Tissue Extracts; Venoms | 1974 |
Platelet aggregation and haemolysis induced in rats by intravenous infusion of ADP - effect of potentially antithrombotic drugs.
Topics: Adenosine Diphosphate; Animals; Aspirin; Depression, Chemical; Female; Hemoglobins; Hemolysis; Infusions, Parenteral; Injections, Intravenous; Lysine; Microscopy, Phase-Contrast; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins E; Pyrimidines; Rats; Stimulation, Chemical; Time Factors | 1974 |
Measurement of platelet aggregation in flowing blood with the use of a filter.
Topics: Adenosine Diphosphate; Animals; Aspirin; Dietary Fats; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Filtration; Hematologic Diseases; Humans; In Vitro Techniques; Platelet Aggregation; Rats; Time Factors | 1974 |
Effect of prostaglandin E 2 and aspirin on the secondary aggregation of human platelets.
Topics: Adenosine Diphosphate; Adhesiveness; Aspirin; Carrageenan; Collagen; Humans; In Vitro Techniques; Prostaglandin Antagonists; Prostaglandins | 1972 |
On the mechanism of platelet aggregation induced by heparin, protamine and polybrene.
Topics: Adenosine; Adenosine Diphosphate; Aspirin; Blood Platelets; Cell Membrane; Edetic Acid; Heparin; Heparin Antagonists; In Vitro Techniques; Platelet Adhesiveness; Polymers; Protamines | 1972 |
Platelet factor-4--properties and clinical significance.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation; Blood Coagulation Factors; Blood Platelets; Fibrin; Freezing; Glomerulonephritis; Heparin Antagonists; Humans; Indomethacin; Microcirculation; Serotonin | 1972 |
[Experimental arterial thrombosis. In vivo and in the vitro effects of aspirin and prostaglandin E1].
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Blood Platelets; Cerebral Arteries; Collagen; In Vitro Techniques; Prostaglandins; Rabbits; Thrombosis | 1972 |
Effect of acetylsalicylic acid on platelet behaviour in vitro and in vivo.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Buffers; Collagen; Dose-Response Relationship, Drug; Ear; Embolism; Endothelium; In Vitro Techniques; Injections, Intravenous; Lasers; Platelet Adhesiveness; Rabbits; Time Factors; Tromethamine | 1972 |
Inhibition of platelet aggregation by drugs.
Topics: Adenosine; Adenosine Diphosphate; Animals; Aspirin; Blood Cell Count; Blood Coagulation; Blood Platelets; Collagen; Densitometry; Depression, Chemical; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Injections, Intravenous; Methods; Muscle, Smooth; Papaverine; Phenylbutazone; Platelet Adhesiveness; Rabbits; Temperature; Thrombin; Vasodilator Agents | 1972 |
Influence of some drugs on platelet aggregation: a study in hypertensive patients.
Topics: Adenosine Diphosphate; Anti-Inflammatory Agents; Aspirin; Benzyl Compounds; Blood Cell Count; Blood Coagulation; Blood Platelets; Dimethylamines; Dipyridamole; Humans; Hypertension; In Vitro Techniques; Indazoles; Indomethacin; Phenylbutazone; Platelet Adhesiveness; Reserpine; Thrombosis; Time Factors | 1972 |
Potentiation of the inhibitory effect of some antiaggregating drugs in " vitro".
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Carbon Radioisotopes; Collagen; Densitometry; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; Ergolines; Humans; In Vitro Techniques; Methods; Nicotinic Acids; Platelet Adhesiveness; S-Adenosylmethionine; Serotonin | 1972 |
Effects of drugs on platelet aggregation: attempt at quantitative comparison of inhibitory effects.
Topics: Adenine; Adenosine Diphosphate; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Cardiac Glycosides; Collagen; Coumarins; Depression, Chemical; Dipyridamole; Dose-Response Relationship, Drug; Epinephrine; Humans; In Vitro Techniques; Methods; Papaverine; Platelet Adhesiveness; Pyrazoles; Xanthines | 1972 |
The effect of antiadhesive drugs on platelet function and metabolism.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation Factors; Blood Platelets; Cell Membrane; Collagen; Cytoplasmic Granules; Densitometry; Dipyridamole; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Glucose; Glycolysis; Humans; In Vitro Techniques; Lactates; Lipoproteins; Microscopy, Electron; Mitochondria; Platelet Adhesiveness; Pyruvate Kinase | 1972 |
Clinical and biochemical characteristics of a primary platelet disorder.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Ascorbic Acid; Aspirin; Blood Coagulation Factors; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets; Cell Membrane; Collagen; Epinephrine; Glass; Hemorrhage; Humans; In Vitro Techniques; Kaolin; Platelet Adhesiveness; Temperature; Thrombin | 1972 |
Platelet aggregation by Thrombofax.
Topics: Adenosine Diphosphate; Afibrinogenemia; Anti-Inflammatory Agents; Aspirin; Blood Platelets; Citrates; Densitometry; Dose-Response Relationship, Drug; Drug Stability; Drug Storage; Epinephrine; Factor V Deficiency; Factor VII Deficiency; Factor XIII Deficiency; Fatty Acids, Nonesterified; Heparin; Humans; Platelet Adhesiveness; Serum Albumin; Temperature; Thromboplastin; Time Factors | 1972 |
The possible role of platelets as trigger in intravascular coagulation associated with acute hyperparathyroidism.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Cell Count; Blood Platelets; Calcium; Carcinoma 256, Walker; Collagen; Disseminated Intravascular Coagulation; Female; Fibrinogen; Hypercalcemia; Hyperparathyroidism; Neoplasm Transplantation; Parathyroid Hormone; Platelet Adhesiveness; Radiation Effects; Rats; Sarcoma, Yoshida; Thromboplastin; Time Factors; Transplantation, Homologous | 1972 |
Aggregation and release reaction in normal and abnormal platelets.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation Factors; Blood Platelet Disorders; Blood Platelets; Calcium; Centrifugation; Collagen; Depression, Chemical; Dose-Response Relationship, Drug; Epinephrine; Fibrinogen; Humans; In Vitro Techniques; Kaolin; Magnesium; Platelet Adhesiveness; Stimulation, Chemical; Temperature; Thrombin | 1972 |
Secretory mechanisms. Behaviour of adenine nucleotides during the platelet release reaction induced by adenosine diphosphate and adrenaline.
Topics: Adenine; Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Aspirin; Blood Coagulation; Blood Platelets; Carbon Isotopes; Cattle; Collagen; Epinephrine; Glycolysis; Horses; Humans; Hypoxanthines; In Vitro Techniques; Inosine Nucleotides; Oxidative Phosphorylation; Thrombin; Tritium | 1972 |
Inhibition of thrombosis on vascular catheters in cats.
Topics: Adenosine Diphosphate; Animals; Aspirin; Carbon Isotopes; Catheterization; Cats; Connective Tissue; Humans; In Vitro Techniques; Injections, Intraperitoneal; Injections, Intravenous; Platelet Adhesiveness; Serotonin; Thrombosis; Vena Cava, Inferior | 1973 |
Platelet factor 4 in platelet disorders--storage location and the requirement of endogenous ADP for its release.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation; Blood Platelet Disorders; Blood Platelets; Collagen; Epinephrine; Humans; Platelet Adhesiveness; Serotonin | 1973 |
Aspirin as an antiplatelet agent: template bleeding time as a monitor of therapy.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Coagulation; Blood Coagulation Tests; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Epinephrine; Female; Hemostasis; Humans; Male; Methods; Platelet Adhesiveness; Time Factors | 1973 |
Clinical application of platelet aggregation.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Dipyridamole; Epinephrine; Humans; Intracranial Embolism and Thrombosis; Platelet Adhesiveness; Thrombin; Thrombosis; Warfarin | 1973 |
Effect of temperature on ADP-induced platelet aggregation. Its significance in studying anti-aggregating drugs.
Topics: Adenosine Diphosphate; Aspirin; Dipyridamole; Ergolines; Humans; In Vitro Techniques; Platelet Adhesiveness; Temperature; Time Factors | 1973 |
Ultrastructural findings in storage pool disease and aspirin-like defects of platelets.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelet Disorders; Blood Platelets; Collagen; Cytoplasmic Granules; Humans; Microscopy, Electron; Platelet Adhesiveness; Serotonin | 1973 |
[Experimental platelet aggregation and arterial thrombosis. Effect of aspirin].
Topics: Adenosine Diphosphate; Animals; Arterial Occlusive Diseases; Aspirin; Blood Platelets; Collagen; Epinephrine; Humans; In Vitro Techniques; Platelet Adhesiveness; Rabbits; Thrombosis | 1973 |
Inhibition of primary ADP-induced platelet aggregation in normal subjects after administration of nitrofurantoin (furadantin).
Topics: Adenosine Diphosphate; Administration, Oral; Aspirin; Blood Platelets; Buffers; Collagen; Depression, Chemical; Female; Humans; Kinetics; Nitrofurantoin; Prostaglandins; Theophylline; Time Factors | 1973 |
The potentiation of platelet aggregation and adhesion by heparin in vitro and in vivo.
Topics: Adenosine Diphosphate; Aspirin; Cell Aggregation; Cell Count; Cellophane; Collagen; Densitometry; Drug Synergism; Epinephrine; Heparin; Humans; In Vitro Techniques; Platelet Adhesiveness | 1973 |
Enhancement of ADP-induced platelet aggregation by adrenaline in vivo and its prevention.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Densitometry; Endothelium; Epinephrine; Injections, Intravenous; Male; Norepinephrine; Phenoxybenzamine; Plasma; Platelet Adhesiveness; Propranolol; Pyridinolcarbamate; Rabbits | 1973 |
Commentary. Drugs inhibiting platelet function.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Dextrans; Humans; Penicillin G; Platelet Adhesiveness; Surface Properties; Thromboembolism | 1973 |
Effect of aspirin on the thrombelastogram of human blood.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation Tests; Blood Platelets; Calcium Chloride; Clot Retraction; Epinephrine; Humans; In Vitro Techniques; Platelet Adhesiveness; Thrombelastography | 1973 |
Effect of aspirin and benadryl on human platelet oxidative phosphorylation and aggregation.
Topics: Adenosine Diphosphate; Antimycin A; Aspirin; Blood Platelets; Cyanides; Dinitrophenols; Diphenhydramine; Humans; Hydrazones; Oligomycins; Oxidative Phosphorylation; Platelet Adhesiveness | 1973 |
Systemic effects of ADP-induced platelet aggregation and their modification by aspirin and by pyridinolcarbamate.
Topics: Adenosine Diphosphate; Animals; Arrhythmias, Cardiac; Aspirin; Blood Cell Count; Blood Platelets; Bradycardia; Carbamates; Carotid Arteries; Central Venous Pressure; Humans; Hypolipidemic Agents; Hypotension; Microcirculation; Oxygen; Partial Pressure; Platelet Adhesiveness; Pyridinolcarbamate; Rats | 1973 |
Factors affecting production of platelet aggregates.
Topics: Adenosine Diphosphate; Animals; Aspirin; Capillaries; Cecum; Chiroptera; Electric Injuries; Endothelium; Erythrocytes; Lasers; Mesenteric Arteries; Mesenteric Veins; Microcirculation; Motion Pictures; Platelet Adhesiveness; Rats; Wings, Animal | 1973 |
The measurement of intravascular aggregation by continuous platelet counting.
Topics: Adenosine; Adenosine Diphosphate; Animals; Aspirin; Blood Cell Count; Blood Platelets; Catheterization; Citrates; Dipyridamole; Dogs; Guinea Pigs; Methysergide; Platelet Adhesiveness; Prostaglandins; Rabbits; Serotonin; Serotonin Antagonists | 1973 |
Effect of 4,5-diphenyl-2-bis-(2-hydroxyethyl)aminoxazol (ditazol) on platelet aggregation, adhesiveness and bleeding time.
Topics: Adenosine; Adenosine Diphosphate; Adult; Analysis of Variance; Animals; Anti-Inflammatory Agents; Aspirin; Blood Coagulation; Collagen; Dipyridamole; Drug Interactions; Epinephrine; Ethanol; Ethanolamines; Humans; Male; Mice; Middle Aged; Oxazoles; Phenylbutazone; Platelet Adhesiveness; Rabbits; Time Factors | 1973 |
[Animal experiment studies on the inhibition of platelet aggregation by verapamil in vitro and in vivo].
Topics: Adenosine Diphosphate; Animals; Aspirin; Depression, Chemical; Dipyridamole; Dogs; Fatty Acids; Humans; In Vitro Techniques; Male; Papaverine; Platelet Adhesiveness; Rats; Thrombocytopenia; Time Factors; Verapamil | 1973 |
Acetylenic analog of arachidonate that acts like aspirin on platelets.
Topics: Adenosine Diphosphate; Arachidonic Acids; Aspirin; Blood Platelets; Carbon Radioisotopes; Collagen; Depression, Chemical; Epinephrine; Fatty Acids, Unsaturated; Female; Humans; Male; Platelet Adhesiveness; Prostaglandins; Serotonin; Thrombin | 1974 |
Inhibition of platelet-induced thrombus formation.
Topics: Adenosine; Adenosine Diphosphate; Aspirin; Blood Platelets; Brain Diseases; Dipyridamole; Epinephrine; Glomerulonephritis; Heart Valve Prosthesis; Humans; Hypertension, Malignant; Ischemia; Myocardial Infarction; Platelet Adhesiveness; Postoperative Complications; Prostaglandins; Pyrimidines; Thromboembolism; Thrombophlebitis; Thrombosis; Xanthines | 1974 |
Platelet aggregation and release by ADP and thrombin: evidence for two separate effects of ADP on platelets, involvement of fibrinogen in release, and mechanism of inhibitory action of acetylsalicylic acid.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation Factors; Blood Platelets; Fibrin; Fibrinogen; Heparin; Humans; In Vitro Techniques; Models, Biological; Models, Theoretical; Platelet Adhesiveness; Prothrombin; Pyrophosphatases; Spectrophotometry; Surface Properties; Thrombin | 1974 |
Release reaction in washed platelet suspensions induced by kaolin and other particles.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Aspirin; Blood Platelet Disorders; Blood Platelets; Calcium; Centrifugation; Edetic Acid; Hemorrhage; Heparin; Humans; Kaolin; Latex; Microspheres; Platelet Adhesiveness; Purpura, Thrombocytopenic; Spectrophotometry; Thrombin; von Willebrand Diseases | 1971 |
The effect of the pyrimidopyrimidine RA 233 on function and metabolism of human platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Blood Platelets; Calcium; Collagen; Edetic Acid; Epinephrine; Humans; Hydrogen-Ion Concentration; Lactates; Oxidative Phosphorylation; Platelet Adhesiveness; Pyrimidines; Pyruvates | 1971 |
Thrombocytopathia due to abnormalities in platelet release reaction--studies on six unrelated patients.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adult; Aspirin; Blood Coagulation Factors; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets; Collagen; Connective Tissue; Epinephrine; Female; Glass; Hemoglobinometry; Humans; Kaolin; Leukocyte Count; Lipoproteins; Middle Aged; Platelet Adhesiveness | 1972 |
Inhibition of collagen induced human platelet aggregation.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Collagen; Depression, Chemical; Drug Antagonism; Humans; Hydrogen-Ion Concentration; Platelet Adhesiveness | 1972 |
[Platelet aggregation inhibiting treatment with aspirin. Biological bases. Application to cerebral vascular accidents].
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets; Cell Aggregation; Cerebrovascular Disorders; Humans; Intracranial Embolism and Thrombosis; Ischemic Attack, Transient; Platelet Adhesiveness | 1972 |
Quantitation of platelet aggregation in myeloproliferative disorders.
Topics: Absorption; Adenosine Diphosphate; Aspirin; Collagen; Densitometry; Epinephrine; Humans; Light; Methods; Myeloproliferative Disorders; Platelet Adhesiveness; Time Factors | 1972 |
Platelet aggregometry in Hageman-deficients and in aspirin treated normal subjects.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation Disorders; Collagen; Epinephrine; Factor XI; Factor XII; Humans; Kaolin; Platelet Adhesiveness; Time Factors | 1972 |
Increased platelet aggregation in diabetes mellitus.
Topics: Adenosine Diphosphate; Aspirin; Blood Chemical Analysis; Blood Proteins; Creatinine; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Fluoresceins; Humans; Kidney Failure, Chronic; Platelet Adhesiveness; Proteinuria; Radiography; Retinal Vessels; Urea | 1972 |
Effect of a new anti-inflammatory drug, fenoprofen, on platelet aggregation and thrombus formation.
Topics: Adenosine Diphosphate; Analysis of Variance; Animals; Anti-Inflammatory Agents; Aspirin; Blood Platelets; Collagen; Depression, Chemical; Drug Antagonism; Ethers; Extracorporeal Circulation; Humans; In Vitro Techniques; Mesentery; Microcirculation; Phenylbutazone; Platelet Adhesiveness; Propionates; Rabbits; Thrombosis | 1972 |
The effect of inhibition of the platelet release reaction on platelet behaviour in vitro and in vivo.
Topics: Adenosine Diphosphate; Amitriptyline; Animals; Arteries; Aspirin; Blood Coagulation; Blood Platelets; Centrifugation, Zonal; Collagen; Depression, Chemical; Hydrolysis; Methods; Microcirculation; Platelet Adhesiveness; Rabbits; Time Factors; Tromethamine; Veins | 1972 |
Effect of aspirin on epinephrine-induced lipolysis and platelet aggregation in rats.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Glucose; Collagen; Drug Antagonism; Epinephrine; Fatty Acids, Nonesterified; Glycolysis; Injections, Intraperitoneal; Lipid Mobilization; Male; Platelet Adhesiveness; Rats | 1972 |
[Abnormalities of platelet aggregation during essential thrombocythemia. Effect of aspirin on erythromelalgia].
Topics: Adenosine Diphosphate; Aged; Arteriosclerosis; Aspirin; Blood Cell Count; Blood Platelet Disorders; Blood Platelets; Cell Survival; Chromium Isotopes; Epinephrine; Erythromelalgia; Female; Humans; Kinetics; Male; Middle Aged; Time Factors | 1972 |
The effect of the ingestion of acetylsalicylic acid on platelet function in normal children.
Topics: Adenosine Diphosphate; Aspirin; Blood Cell Count; Blood Coagulation; Blood Platelets; Child; Child, Preschool; Hemostasis; Humans; Infant; Platelet Adhesiveness | 1971 |
[Pharmacodynamic prevention of thrombosis].
Topics: Adenosine Diphosphate; Amitriptyline; Anticoagulants; Aspirin; Collagen; Dipyridamole; Guanethidine; Humans; Imipramine; Papaverine; Thrombin; Thrombosis | 1971 |
Divergent effects of aspirin and salicylate on glucose and glycogen metabolism in human platelets.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Depression, Chemical; Glycogen; Glycolysis; Humans; In Vitro Techniques; Sodium Salicylate | 1971 |
[Effect of drugs on blood platelet characteristics].
Topics: Adenine Nucleotides; Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Blood Platelets; Epinephrine; Fatty Acids, Nonesterified; Humans; Phenylbutazone; Platelet Adhesiveness; Rabbits; Thrombin; Thromboembolism; Thrombosis | 1971 |
Comparison of the effects of drugs on the aggregation of hamster platelets in vivo and in vitro.
Topics: Adenosine; Adenosine Diphosphate; Animals; Aspirin; Blood Volume; Carbon Isotopes; Cheek; Cricetinae; Desipramine; Imipramine; In Vitro Techniques; Iontophoresis; Microcirculation; Platelet Adhesiveness; Sodium Salicylate; Tritium | 1971 |
Action of fibrinogen degradation products and fibrin monomer soluble complexes on platelet aggregation.
Topics: Acid Phosphatase; Adenosine Diphosphate; Antigens; Aspirin; Blood Coagulation; Chromatography, Gel; Collagen; Dialysis; Epinephrine; Fibrin; Fibrinogen; Hot Temperature; Humans; Hydrogen-Ion Concentration; Molecular Weight; Phosphoenolpyruvate; Platelet Adhesiveness; Pyruvate Kinase; Solubility; Thrombin | 1971 |
Dissociation between platelet factor 3 availability and platelet aggregation.
Topics: Absorption; Adenosine; Adenosine Diphosphate; Aspirin; Blood Platelets; Collagen; Glycolysis; Humans; Indomethacin; Oxidative Phosphorylation; Platelet Adhesiveness; Purpura, Thrombocytopenic; Spectrum Analysis; Thromboplastin; Time Factors | 1971 |
[Effect of aspirin on the blood platelets in children].
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Coagulation; Blood Coagulation Factors; Blood Coagulation Tests; Blood Platelets; Child; Child, Preschool; Collagen; Hemophilia A; Humans; von Willebrand Diseases | 1971 |
New platelet diseases.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation Factors; Blood Coagulation Tests; Blood Platelet Disorders; Blood Platelets; Cell Membrane; Collagen; Epinephrine; Humans; Phospholipids; Platelet Adhesiveness; Serotonin; von Willebrand Diseases; Wiskott-Aldrich Syndrome | 1971 |
Effect of aspirin on platelet aggregation and bleeding time in haemophilia and von Willebrand's disease.
Topics: Adenosine Diphosphate; Administration, Oral; Aspirin; Blood Platelets; Epinephrine; Hemophilia A; Humans; Platelet Adhesiveness; Time Factors; von Willebrand Diseases | 1971 |
Experimental basis of platelet aggregation inhibition by acetylsalicylic acid.
Topics: Adenosine Diphosphate; Aspirin; Carotid Artery Thrombosis; Cerebral Infarction; Coronary Circulation; Coronary Disease; Hemodynamics; Humans; Ischemic Attack, Transient; Myocardial Infarction; Platelet Aggregation | 1984 |
Congenital deficiency of thromboxane and prostacyclin.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Blood Coagulation Tests; Blood Platelet Disorders; Cells, Cultured; Chromatography, Thin Layer; Epoprostenol; Hemorrhage; Humans; Male; Oxygenases; Plasma; Platelet Aggregation; Prostaglandins; Thromboxane A2; Thromboxanes | 1980 |
Low dose aspirin, platelet function and prostaglandin synthesis: influence of epinephrine and alpha adrenergic blockade.
Topics: Adenosine Diphosphate; Adrenergic alpha-Antagonists; Arachidonic Acids; Aspirin; Blood Platelets; Calcium; Dose-Response Relationship, Drug; Epinephrine; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandins; Thrombin | 1981 |
Release of a slow-reacting substance from rabbit platelets.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acids; Aspirin; Autacoids; Blood Platelets; Chromatography, High Pressure Liquid; Cysteine; Indomethacin; Kinetics; Lysophosphatidylcholines; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thrombin | 1981 |
Thromboxane A2 in skin-bleeding-time blood and in clotted venous blood before and after administration of acetylsalicylic acid.
Topics: Adenosine Diphosphate; Adult; Aspirin; Bleeding Time; England; Hemorrhage; Hemostasis; Humans; Male; Platelet Aggregation; Platelet Function Tests; Skin; Sweden; Thromboxane A2; Thromboxane B2; Thromboxanes | 1983 |
Platelet changes after placement of aortic prostheses in dogs. I. Biochemical and functional alterations.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aorta; Aspirin; Blood Platelets; Blood Transfusion; Cell Survival; Chemical Phenomena; Chemistry; Dipyridamole; Dogs; Female; Hydroxyindoleacetic Acid; Male; Platelet Aggregation; Platelet Transfusion; Prostheses and Implants; Serotonin | 1981 |
Experimental model of thrombus adherence to the vessel wall.
Topics: Adenosine Diphosphate; Animals; Aprotinin; Aspirin; Female; Hematocrit; Platelet Adhesiveness; Rats; Thrombosis | 1982 |
[In vitro aggregation of rat platelets by cumulative doses of ADP: influence of 3 antiaggregants and a protease inhibitor, aprotinin].
Topics: Adenosine Diphosphate; Animals; Aprotinin; Aspirin; In Vitro Techniques; Isoproterenol; Male; Platelet Aggregation; Rats; Rats, Inbred Strains; Theophylline | 1983 |
Selective PF4 release in vitro induced by heparin and related glycosaminoglycans (GAGs)--correlation with beta-TG release and platelet aggregation.
Topics: Adenosine Diphosphate; Adult; Aspirin; Beta-Globulins; beta-Thromboglobulin; Glycosaminoglycans; Heparin; Humans; Platelet Aggregation; Platelet Factor 4 | 1984 |
Platelet function in blood from the coronary sinus in patients with arteriosclerotic heart disease.
Topics: Adenosine Diphosphate; Aspirin; beta-Thromboglobulin; Blood Platelets; Collagen; Coronary Disease; Coronary Vessels; Humans; Imidazoles; In Vitro Techniques; Male; Platelet Aggregation; Platelet Count; Vena Cava, Superior | 1983 |
[Prevention of thrombosis by thrombocyte inhibitors. 1. Cell regulation mechanisms and pharmacological modification].
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Cyclic AMP; Dextrans; Dipyridamole; Humans; Hydroxychloroquine; Indomethacin; Platelet Aggregation; Prostaglandins; Sulfinpyrazone; Thrombosis; Thromboxane A2 | 1980 |
Aggregation-induced alterations in human platelet membranes: a spin label study.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Cell Membrane; Electron Spin Resonance Spectroscopy; Epinephrine; Humans; Platelet Aggregation; Spin Labels; Thrombin | 1980 |
A biphasic effect of prostacyclin (PGI2) on platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Aspirin; Cyclic AMP; Dipyridamole; Epoprostenol; Humans; Imidazoles; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandins; Rabbits; Rats; Thrombin; Thromboxane-A Synthase | 1980 |
Inhibitory effect of tiaramide of aggregation in vivo and on electrophoresis of rabbit platelets.
Topics: Adenosine Diphosphate; Animals; Aspirin; Benzothiazoles; Cyclic AMP; Depression, Chemical; Electrophoresis; Female; In Vitro Techniques; Indomethacin; Male; Piperazines; Platelet Aggregation; Platelet Count; Prostaglandin Endoperoxides; Rabbits; Thiazoles | 1980 |
A role for prostaglandins and thromboxanes in the exposure of platelet fibrinogen receptors.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Epinephrine; Fibrinogen; Humans; Indomethacin; Platelet Aggregation; Platelet Membrane Glycoproteins; Prostaglandins; Prostaglandins A; Prostaglandins H; Receptors, Cell Surface; Thromboxanes | 1981 |
Human platelet activation by an alkylacetyl analogue of phosphatidylcholine.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Coagulation Factors; Blood Platelets; Calcium; Cyclooxygenase Inhibitors; Epinephrine; Epoprostenol; Humans; Ion Channels; Platelet Activating Factor; Platelet Aggregation; Serotonin | 1982 |
Induction of human platelet fibrinogen receptors by epinephrine in the absence of released ADP.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Cell Separation; Creatine Kinase; Edetic Acid; Epinephrine; Humans; Kinetics; Phentolamine; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Serotonin | 1982 |
Studies on aspirin derivatives with very little side effect. IV. Inhibitory effect of aspirin-isopropylantipyrine (AIA) on several experimental thromboses.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Antipyrine; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclic AMP; Epoprostenol; Malondialdehyde; Muscle Contraction; Rats; Thrombosis | 1983 |
Effects of acetylsalicylic acid on platelet aggregation before and during increase in dietary eicosapentaenoic acid.
Topics: Adenosine Diphosphate; Adult; Animals; Aspirin; Blood Platelets; Collagen; Dietary Fats; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Fishes; Humans; Male; Platelet Aggregation; Prostaglandins | 1983 |
Effect of epinephrine on fibrinogen receptor exposure by aspirin-treated platelets and platelets from concentrates in response to ADP and thrombin.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Chromatography, Gel; Epinephrine; Humans; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Serotonin; Thrombin | 1984 |
Platelet activation induces the formation of a stable gelsolin-actin complex from monomeric gelsolin.
Topics: Actins; Adenosine Diphosphate; Aspirin; Blood Platelets; Calcimycin; Calcium; Calcium-Binding Proteins; Egtazic Acid; Gelsolin; Humans; Molecular Weight; Tetracaine; Thrombin | 1984 |
Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Epoprostenol; Humans; Male; Platelet Aggregation; Prostaglandins; Radioimmunoassay; Thromboxanes | 1983 |
The stimulatory effect of prostacyclin (PGI2) on isolated rabbit and rat aorta is probably associated to the generation of a thromboxane A2 (TXA2) "like-material".
Topics: Adenosine Diphosphate; Animals; Aorta, Thoracic; Aspirin; Corticosterone; Epoprostenol; Imidazoles; In Vitro Techniques; Indomethacin; Male; Prostaglandins; Rabbits; Rats; Species Specificity; Thromboxane A2; Thromboxanes; Vasoconstriction | 1983 |
Comparison of the effects of acetylsalicylic acid and sodium salicylate on prolongation of rat cardiac allograft survival and on inhibition of rat platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Aspirin; Gastric Mucosa; Graft Survival; Heart; Heart Transplantation; Platelet Aggregation; Rats; Sodium Salicylate | 1983 |
Effects of dazoxiben and low-dose aspirin on platelet behaviour in man.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Epinephrine; Female; Humans; Imidazoles; Male; Oxidoreductases; Thromboxane-A Synthase | 1983 |
Inhibition of platelet aggregation by a new agent, 2,2'-dithiobis-(N-2-hydroxypropyl benzamide) (KF4939).
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Benzamides; Collagen; Dose-Response Relationship, Drug; Fibrinolytic Agents; Humans; In Vitro Techniques; Male; Mice; Papaverine; Platelet Aggregation; Rabbits; Rats; Rats, Inbred Strains; Thrombin; Thrombocytopenia; Thrombosis; Thromboxane A2 | 1983 |
The role of ADP secretion and thromboxane synthesis in factor VIII binding to platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Factor VIII; Humans; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxane A2; Thromboxanes | 1983 |
Lipoxygenase inhibitors alter aggregation and adhesiveness of human blood platelets from aspirin-treated patients.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Catechols; Collagen; Humans; Lipoxygenase Inhibitors; Masoprocol; Platelet Adhesiveness; Platelet Aggregation | 1983 |
Some properties of mouse platelets.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Epoprostenol; Indomethacin; Lipoxygenase; Male; Mice; Mice, Inbred ICR; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases | 1983 |
Platelet aggregation studies in whole human blood.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Edetic Acid; Female; Humans; In Vitro Techniques; Male; Microscopy, Electron, Scanning; Platelet Aggregation; Platelet Count | 1983 |
Relationships between the chemical constitution of aggregation inhibitors and human blood platelet response profile.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Calcium; Calcium Channel Blockers; Carbamates; Chlorpromazine; Gallic Acid; Humans; In Vitro Techniques; Piperidines; Platelet Aggregation; Propranolol; Thrombin | 1984 |
Effects of tris on responses of human and rabbit platelets to aggregating agents.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Calcium; Collagen; Dose-Response Relationship, Drug; Humans; Platelet Activating Factor; Platelet Aggregation; Rabbits; Serotonin; Thrombin; Tromethamine | 1984 |
Evidence for the involvement of arachidonic acid metabolites in spontaneous and drug-induced contractions of rat urinary bladder.
Topics: Adenosine Diphosphate; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Diet; Fatty Acids, Essential; Hexamethonium Compounds; Indomethacin; Ketoprofen; Male; Muscle Contraction; Physostigmine; Piroxicam; Rats; Rats, Inbred Strains; Tetrodotoxin; Thiazines; Urinary Bladder | 1984 |
Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP.
Topics: Adenosine Diphosphate; Apyrase; Aspirin; Blood Platelets; Calcimycin; Enzyme Activation; Humans; In Vitro Techniques; Lipids; Phospholipases; Prostaglandin-Endoperoxide Synthases; Type C Phospholipases | 1984 |
What's provoking different aggregation between arterial and venous platelets in the rat?
Topics: Adenosine Diphosphate; Animals; Arteries; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Female; Lung; Male; Myocardium; Papaverine; Platelet Aggregation; Prostaglandin Antagonists; Rats; Tranylcypromine; Veins | 1984 |
Inhibition of thrombocytopenic episodes caused by the Arthus reaction, the sub-lethal Forssman reaction and ADP.
Topics: Adenosine Diphosphate; Animals; Antibodies; Arthus Reaction; Aspirin; Dipyridamole; Forssman Antigen; Guinea Pigs; Humans; Nervous System Diseases; Platelet Count; Pyridines; Sulfides; Sulfinpyrazone; Thiophenes; Thrombocytopenia; Ticlopidine | 1980 |
Thrombospondin plays a role in platelet-platelet recognition during release-related aggregation.
Topics: Adenosine Diphosphate; Antibodies, Monoclonal; Aspirin; Fibrinogen; Glycoproteins; Humans; Immune Sera; Platelet Aggregation; Thrombospondins | 1984 |
Vasoactive agents and production of thrombosis during intravascular coagulation 1--comparative effects of norepinephrine in thrombin and adenosine diphosphate (ADP) treated rabbits.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aminocaproic Acid; Animals; Aspirin; Blood Coagulation; Blood Coagulation Tests; Disseminated Intravascular Coagulation; Norepinephrine; Rabbits; Shwartzman Phenomenon; Thrombin; Thrombosis | 1984 |
The role of the platelets.
Topics: Adenosine Diphosphate; Angina Pectoris; Animals; Aspirin; Blood Platelets; Coronary Disease; Hemodynamics; Humans; Muscle, Smooth, Vascular; Platelet Aggregation; Thrombosis | 1984 |
In vivo study of platelet aggregation in rats.
Topics: Adenosine Diphosphate; Animals; Aspirin; Collagen; Diet; Dose-Response Relationship, Drug; Male; Methods; Platelet Aggregation; Platelet Count; Rats; Rats, Inbred Strains; Thiophenes; Thrombosis; Ticlopidine | 1984 |
Independency of release reaction on aggregation in ADP stimulated-platelet.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Humans; In Vitro Techniques; Kinetics; Platelet Aggregation | 1984 |
Changes in size distribution curve on the process of platelet aggregation induced by various agents.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Collagen; Epinephrine; Humans; In Vitro Techniques; Platelet Aggregation | 1984 |
Ex vivo and in vivo evaluation of drugs that inhibit platelet function.
Topics: Adenosine Diphosphate; Animals; Aspirin; Bleeding Time; Blood Platelets; Collagen; Dipyridamole; Imidazoles; Male; Papio; Platelet Aggregation; Sulfinpyrazone; Thiazines; Thiophenes; Ticlopidine | 1983 |
Total and selective desensitisation of human platelets to synthetic platelet activating factor (PAF): evidence that extracellular PAF does not mediate collagen-induced aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Extracellular Space; Humans; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic | 1983 |
Interactions between neoplastic cells with different metastasizing capacity and platelet function.
Topics: Adenosine Diphosphate; Adult; Animals; Aspirin; Blood Platelets; Cell Line; Cells, Cultured; Culture Media; Fibrosarcoma; Humans; Mice; Neoplasm Metastasis; Platelet Aggregation; Sarcoma, Experimental; Serotonin | 1983 |
Antiplatelet drugs and thrombosis prevention: ticlopidine in perspective.
Topics: Adenosine Diphosphate; Aspirin; Bleeding Time; Blood Platelets; Fibrinolytic Agents; Humans; Thiophenes; Thrombosis; Ticlopidine | 1984 |
On a possible interaction between ADP and mechanical stimulation in platelet activation.
Topics: Adenosine Diphosphate; Aspirin; Cell Separation; Centrifugation; Humans; Phosphoenolpyruvate; Platelet Aggregation; Pyruvate Kinase | 1984 |
The effects of an ASA-like hydroperoxide compound on adenosine diphosphate induced platelet aggregation.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Aspirin; Humans; Middle Aged; Phthalic Acids; Phthalic Anhydrides; Platelet Aggregation | 1984 |
Platelet-platelet recognition during aggregation: distinct mechanisms determined by the release reaction.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Fibrinogen; Humans; Platelet Aggregation | 1984 |
Activation of platelets by autogenous vein grafts is not prevented by acetylsalicylic acid and dipyridamole.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Aspirin; Dipyridamole; Dose-Response Relationship, Drug; Jugular Veins; Platelet Aggregation; Rabbits; Time Factors | 1984 |
Effect of aspirin and aspirin lysinate on platelet function in smokers and non-smokers.
Topics: Adenosine Diphosphate; Adult; Aspirin; Bleeding Time; Blood Platelets; Humans; Lysine; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Smoking; Thrombosis | 1980 |
Increased platelet aggregation induced by glucagon administration.
Topics: Adenosine Diphosphate; Adult; Aspirin; Female; Glucagon; Humans; Male; Middle Aged; Platelet Aggregation | 1980 |
The effect of acetylsalicylic acid. Dipyridamole and K 3920 on the secretion of platelet factor 4.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation Factors; Blood Platelets; Collagen; Dipyridamole; Epinephrine; Humans; Indoles; Isoindoles; Phenylbutyrates; Platelet Factor 4 | 1980 |
The action of cyclooxygenase and prostacyclin-synthetase inhibitors on platelet-vessel wall interaction.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Blood Platelets; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Epoprostenol; Flurbiprofen; Indomethacin; Intramolecular Oxidoreductases; Male; Mesenteric Arteries; Perfusion; Prostaglandins; Rats | 1980 |
One, two, three or more pathways for platelet aggregation.
Topics: Acetophenones; Adenosine Diphosphate; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Humans; Lysophosphatidylcholines; Platelet Activating Factor; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thrombin; Thromboxane A2 | 1980 |
Interaction of rat platelets with Listeria monocytogenes.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Female; Indomethacin; Listeria monocytogenes; Listeriosis; Platelet Aggregation; Rats; Serotonin | 1981 |
Platelet adherence to collagen: role of prostaglandin-thromboxane synthesis.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Collagen; Dose-Response Relationship, Drug; Humans; Imidazoles; Indomethacin; Magnesium; Middle Aged; Platelet Adhesiveness; Prostaglandins; Serotonin; Temperature; Thromboxanes | 1981 |
Testosterone potentiation of ionophore and ADP induced platelet aggregation: relationship to arachidonic acid metabolism.
Topics: Adenosine Diphosphate; Animals; Anti-Bacterial Agents; Arachidonic Acids; Aspirin; Blood Platelets; Calcimycin; Humans; Indomethacin; Platelet Aggregation; Rabbits; Serum Albumin; Testosterone; Thromboxane A2 | 1981 |
Reevaluation of sex differences in platelet aggregation in a physiologic system.
Topics: Adenosine Diphosphate; Adult; Aging; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Female; Humans; Infant, Newborn; Male; Platelet Aggregation; Sex Factors | 1981 |
The effect of arachidonic acid on the aggregability of human platelet rich plasma.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Humans; Male; Platelet Aggregation; Time Factors | 1982 |
The facilitating effects of adrenaline on platelet aggregation.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Drug Synergism; Epinephrine; Humans; Platelet Aggregation; Radioimmunoassay; Thromboxane B2 | 1982 |
Structure-activity studies of aspirin and related compounds on platelet aggregation, arachidonic acid metabolism in platelets and artery, and arterial prostacyclin activity.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Aspirin; Benzoates; Dinoprostone; Platelet Aggregation; Prostaglandins E; Rabbits; Rats; Structure-Activity Relationship | 1982 |
Opposite effect of lysine on platelet aggregation induced by arachidonate and by other aggregants.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Dose-Response Relationship, Drug; Drug Synergism; Humans; Lysine; Male; Malondialdehyde; Platelet Aggregation; Rats; Rats, Inbred Strains; Ristocetin; Serotonin | 1982 |
Effect of acetylsalicylic acid on platelet aggregation and thromboxane B2 production in flowing aortic blood in the rat studied with a filter loop technique.
Topics: Adenosine Diphosphate; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Aspirin; Male; Methods; Platelet Aggregation; Rats; Rats, Inbred Strains; Salicylates; Thromboxane B2; Thromboxanes | 1982 |
Availability of endothelial von Willebrand factor and platelet function in diabetic patients infused with a vasopressin analogue.
Topics: Adenosine Diphosphate; Adult; Antigens; Arginine Vasopressin; Aspirin; Blood Coagulation Factors; Deamino Arginine Vasopressin; Diabetes Mellitus; Endothelium; Factor VIII; Humans; Male; Platelet Adhesiveness; Platelet Aggregation; von Willebrand Factor | 1982 |
Platelet activating factor (PAF) causes human platelet aggregation through the mechanism of membrane modulation.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cell Membrane; Epinephrine; Epoprostenol; Humans; Platelet Activating Factor; Platelet Aggregation; Thromboxane B2; Time Factors | 1982 |
Platelet aggregation measured in rabbit whole blood: in vitro study of 3 aggregating agents and ex vivo inhibition by aspirin and ticlopidine.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; In Vitro Techniques; Platelet Aggregation; Platelet Count; Rabbits; Thiophenes; Ticlopidine | 1982 |
Acetal phosphatidic acids: novel platelet aggregating agents.
Topics: Adenosine Diphosphate; Animals; Aspirin; Chlorpromazine; Drug Interactions; Humans; In Vitro Techniques; Phosphatidic Acids; Platelet Aggregation; Quinacrine; Sheep; Species Specificity | 1983 |
Subcellular localization and secretion of factor V from human platelets.
Topics: Adenosine Diphosphate; Aspirin; Biological Transport, Active; Blood Platelets; Cell Compartmentation; Collagen; Epinephrine; Factor V; Humans; Polyethylene Glycols; Prostaglandins; Serotonin | 1981 |
Differential inhibition of prostacyclin production and platelet aggregation by aspirin in humans.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aspirin; Blood Platelets; Collagen; Epinephrine; Epoprostenol; Female; Humans; Kinetics; Male; Malonates; Malondialdehyde; Platelet Aggregation; Prostaglandins | 1980 |
Activation of guinea-pig platelets induced by convulxin, a substance extracted from the venom of Crotalus durissus cascavella.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Blood Platelets; Crotalid Venoms; Epoprostenol; Guinea Pigs; In Vitro Techniques; Indomethacin; Lectins, C-Type; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1980 |
Prostacyclin (PGI2) inhibits the development in human platelets of ADP and arachidonic acid-induced shape change and procoagulant activity.
Topics: Adenosine Diphosphate; Arachidonic Acids; Aspirin; Blood Platelets; Epoprostenol; Humans; Platelet Aggregation; Prostaglandins | 1980 |
Platelet physiology--facts and fiction.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Cell Adhesion; Collagen; Epoprostenol; Hemostasis; Humans; Platelet Aggregation; Prostaglandins; Thrombin | 1981 |
Aspirin inhibits platelet function independent of the acetylation of cyclo-oxygenase.
Topics: Acetylation; Adenosine Diphosphate; Animals; Aspirin; Bleeding Time; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Oxygenases; Platelet Aggregation; Rabbits; Serotonin; Thromboxane B2 | 1982 |
[Fused quinolines, VII: Inhibition of blood platelet aggregation by fused quinolines carrying 2-dimethylaminopropylmercapto substituents (author's transl)].
Topics: Adenosine Diphosphate; Aspirin; Humans; In Vitro Techniques; Platelet Aggregation; Quinolines | 1982 |
Dosage frequency for suppression of platelet function by low dose aspirin therapy.
Topics: Adenosine Diphosphate; Aspirin; Cell Survival; Collagen; Depression, Chemical; Dose-Response Relationship, Drug; Epinephrine; Humans; Malondialdehyde; Platelet Aggregation; Platelet Function Tests; Thrombosis; Thromboxane B2 | 1982 |
[In vitro effect of culture fluids from neoplastic tissues on platelet aggregation. I. Human tumors of the gastrointestinal tract].
Topics: Adenosine Diphosphate; Adult; Aspirin; Culture Media; Female; Gastrointestinal Neoplasms; Humans; Male; Platelet Aggregation | 1982 |
[In vitro effect of culture fluids from neoplastic tissues on platelet aggregation. II. Experimental tumors].
Topics: Adenosine Diphosphate; Adult; Animals; Aspirin; Culture Media; Female; Humans; Male; Mice; Platelet Aggregation; Sarcoma, Experimental | 1982 |
Adrenaline and PAF-acether synergize to trigger cyclooxygenase-independent activation of plasma-free human platelets.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Aspirin; Creatine Kinase; Drug Synergism; Epinephrine; Humans; Phosphocreatine; Platelet Activating Factor; Platelet Aggregation; Rabbits; Stimulation, Chemical; Thromboxane B2 | 1982 |
Platelet accumulation on fibrinogen-blockade of the prostaglandin and ADP pathways.
Topics: Adenosine Diphosphate; Aspirin; Creatine Kinase; Humans; In Vitro Techniques; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins; Serotonin; Thrombin | 1982 |
Platelet aggregation in laminar flow. II. Shear rate and ADP-dependent effects of acetylsalicylic acid and indomethacin.
Topics: Adenosine Diphosphate; Aspirin; Environment, Controlled; Humans; Indomethacin; Nephelometry and Turbidimetry; Platelet Adhesiveness; Platelet Aggregation; Time Factors | 1982 |
The relationship between the production of thromboxane B2 and malondialdehyde by human blood platelets.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Humans; In Vitro Techniques; Malonates; Malondialdehyde; Platelet Aggregation; Thromboxane B2; Thromboxane-A Synthase; Thromboxanes | 1980 |
Modulation of the inhibitory action of prostaglandin E1 on platelet aggregation in rats: a study with ticlopidine, aspirin, dipyridamole and sulfinpyrazone.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Aspirin; Dipyridamole; Male; Phosphorylation; Platelet Aggregation; Prostaglandins E; Rats; Rats, Inbred Strains; Sulfinpyrazone; Thiophenes; Ticlopidine | 1982 |
Effects of ethanol and of other factors on ADP-induced aggregation of human blood platelets in vitro.
Topics: Adenosine Diphosphate; Adult; Aspirin; Ethanol; Humans; Male; Platelet Aggregation; Time Factors | 1980 |
Effects of very low versus standard dose acetyl salicylic acid, dipyridamole and sulfinpyrazone on platelet function and thromboxane formation in man.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Dipyridamole; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation; Sulfinpyrazone; Thromboxane B2; Thromboxanes | 1981 |
Some characteristics of mouse platelet aggregation and a comparison of the activity of a range of compounds in mouse and human platelet-rich plasma in vitro.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Collagen; Depression, Chemical; Epinephrine; Humans; In Vitro Techniques; Mice; Papaverine; Platelet Aggregation; Prostaglandins E; Serotonin | 1981 |
A native whole blood assay for blood-materials interaction.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Blood Physiological Phenomena; Blood Platelets; Citrates; Collagen; Imipramine; Methods; Rabbits; Science | 1981 |
Ion flux and platelet activation.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Calcium; Epinephrine; Humans; In Vitro Techniques; Ions; Sodium | 1981 |
Platelet aggregation independent of ADP release or prostaglandin synthesis in patients with hermansky-Pudlak syndrome.
Topics: Adenosine Diphosphate; Albinism; Arachidonic Acids; Aspirin; Blood Platelets; Epinephrine; Hemorrhagic Disorders; Humans; Platelet Aggregation; Prostaglandins; Thrombin; Thromboxanes | 1981 |
Effects of 6-[p-(4-phenylacetylpiperazin-1-yl)phenyl]-4,5-dihydro-3(2H)pyridazinone (CCI 17810) and aspirin on platelet aggregation and adhesiveness.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Aspirin; Collagen; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Platelet Adhesiveness; Platelet Aggregation; Pyridazines; Rats | 1981 |
A method for quantitating platelet aggregation and analyzing drug-receptor interactions on platelets in whole blood in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Aspirin; Blood Cell Count; Blood Platelets; Epinephrine; Guinea Pigs; In Vitro Techniques; Phentolamine; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Receptors, Drug; Time Factors | 1981 |
Heparin-induced thrombocytopenia: effect of heparin platelet antibody on platelets.
Topics: Adenosine Diphosphate; Adult; Antibodies; Aspirin; Blood Platelets; Complement Fixation Tests; Dipyridamole; Female; Heparin; Humans; Indomethacin; Male; Malondialdehyde; Middle Aged; Platelet Aggregation; Platelet Factor 3; Thrombocytopenia; Thromboxane B2 | 1981 |
Characterization of the platelet-aggregating activity of tumor cells.
Topics: Adenocarcinoma; Adenosine Diphosphate; Animals; Aspirin; Cell Line; Cell Membrane; Growth Substances; Hirudins; In Vitro Techniques; Kidney Neoplasms; Magnesium; Mice; Neoplasms, Experimental; Neuroblastoma; Platelet Aggregation; Rabbits | 1980 |
[On the inhibition of thrombocyte aggregation by bupranolol / Aggregometric and electron microscopic study in vitro (author's transl)].
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Bupranolol; Humans; In Vitro Techniques; Microscopy, Electron; Platelet Aggregation; Propanolamines; Stereoisomerism | 1980 |
Effects of aspirin and dipyridamole on the degradation of adenosine diphosphate by cultured cells derived from bovine pulmonary artery.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Aspirin; Cattle; Cells, Cultured; Dipyridamole; Platelet Aggregation; Pulmonary Artery | 1980 |
Influence of epinephrine on the aggregation response of aspirin-treated platelets.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Blood Platelets; Epinephrine; Humans; Platelet Aggregation; Serotonin; Thrombin; Thromboxane B2 | 1980 |
Release of human platelet factor V activity is induced by both collagen and ADP and is inhibited by aspirin.
Topics: Adenosine Diphosphate; Antimycin A; Aspirin; Blood Platelets; Cell Compartmentation; Collagen; Deoxyglucose; Depression, Chemical; Factor V; Humans; Organoids; Stimulation, Chemical | 1980 |
Effect of ticlopidine on human platelet responsiveness ex vivo: comparison with aspirin.
Topics: Adenosine Diphosphate; Adult; Aspirin; Collagen; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Pyridines; Serotonin; Thiophenes; Ticlopidine | 1980 |
Prolonged bleeding time in Aleutian mink associated with a cyclo-oxygenase-independent aggregation defect and nucleotide deficit in blood platelets.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aspirin; Bleeding Time; Blood Platelet Disorders; Blood Platelets; Chediak-Higashi Syndrome; Collagen; Female; Indomethacin; Male; Mink; Oxygenases; Platelet Aggregation; Platelet Function Tests | 1980 |
Relative effects of aspirin on platelet aggregation and prostaglandin-mediated coronary vasodilatation in the dog.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Aspirin; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Female; Hemodynamics; Male; Platelet Aggregation; Prostaglandins; Vasodilation | 1980 |
Aspirin- and taurocholate-induced metabolic damage in mammalian gastric mucosa in vitro.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Aspirin; Energy Metabolism; Female; Gastric Acid; Gastric Acidity Determination; Gastric Mucosa; Guinea Pigs; Taurocholic Acid | 1980 |
Thrombin-receptor agonist peptides, in contrast to thrombin itself, are not full agonists for activation and signal transduction in human platelets in the absence of platelet-derived secondary mediators.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Arachidonic Acid; Aspirin; Blood Platelets; Cytoskeleton; Drug Interactions; GTP-Binding Proteins; Hirudins; Humans; Integrin alpha2; Membrane Glycoproteins; Molecular Sequence Data; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activation; Platelet Aggregation; Proto-Oncogene Proteins pp60(c-src); Purinergic P2 Receptor Antagonists; Receptors, Thrombin; Signal Transduction; Thrombin | 1994 |
Aspirin does not affect the flow cytometric detection of fibrinogen binding to, or release of alpha-granules or lysosomes from, human platelets.
Topics: Adenosine Diphosphate; Adult; Antigens, CD; Aspirin; Blood Platelets; Cell Degranulation; Dose-Response Relationship, Drug; Drug Interactions; Fibrinogen; Flow Cytometry; Humans; Male; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Tetraspanin 30; Thrombin | 1994 |
[Evaluation, by flow cytometry, of activated platelet levels after coronarography and intraluminal angioplasty].
Topics: Adenosine Diphosphate; Adult; Aged; Angioplasty, Balloon; Aspirin; Coronary Angiography; Female; Fibrinogen; Flow Cytometry; Humans; Male; Middle Aged; Platelet Activation; Platelet Count | 1995 |
Clinical experience with the Thrombostat 4000.
Topics: Adenosine Diphosphate; Aspirin; Bleeding Time; Blood Coagulation Tests; Cells, Cultured; Epinephrine; Hemostasis; Humans; Platelet Aggregation; Prothrombin Time; Sodium Chloride | 1995 |
Aspirin does not inhibit adenosine diphosphate-induced platelet alpha-granule release.
Topics: Adenosine Diphosphate; Amiloride; Aspirin; Blood Platelets; Carrier Proteins; Cell Membrane; Cytoplasmic Granules; Drug Synergism; Epinephrine; Humans; Hydrogen-Ion Concentration; Lipoxygenase Inhibitors; P-Selectin; Platelet Aggregation; Platelet Membrane Glycoproteins; Serotonin; Sodium-Hydrogen Exchangers | 1993 |
Upregulation of antithrombotic ectonucleotidases by aspirin in human endothelial cells in-vitro.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Apyrase; Aspirin; Cells, Cultured; Chromatography, High Pressure Liquid; Endothelium, Vascular; Fluorescein-5-isothiocyanate; Humans; Spectrometry, Fluorescence; Umbilical Veins; Up-Regulation | 1994 |
Platelet activation induced by a murine monoclonal antibody directed against a novel tetra-span antigen.
Topics: Adenosine Diphosphate; Antibodies, Monoclonal; Aspirin; Dose-Response Relationship, Drug; Humans; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, IgG | 1995 |
Synthesis and antiplatelet effects of the new antithrombotic agent aspalatone with low ulcerogenicity.
Topics: Adenosine Diphosphate; Animals; Antioxidants; Aspirin; Bleeding Time; Collagen; Fibrinolytic Agents; In Vitro Techniques; Lethal Dose 50; Male; Mice; Mice, Inbred ICR; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 1994 |
The effects of aspirin and paracetamol on the aggregation of equine blood platelets.
Topics: Acetaminophen; Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Cell Size; Collagen; Dose-Response Relationship, Drug; Horses; In Vitro Techniques; Nephelometry and Turbidimetry; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1994 |
Development of aspirin resistance in persons with previous ischemic stroke.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Brain Ischemia; Cerebrovascular Disorders; Cohort Studies; Collagen; Dose-Response Relationship, Drug; Drug Resistance; Drug Tolerance; Epinephrine; Female; Follow-Up Studies; Humans; Intracranial Embolism and Thrombosis; Male; Platelet Aggregation; Recurrence | 1994 |
[Thermo-induced structural reorganizations of platelet membranes as affected by aggregation inducers and inhibitors].
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Cell Membrane; Electron Spin Resonance Spectroscopy; Fatty Acids; Molecular Probes; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Temperature; Vitamin E | 1993 |
Effect of picotamide on the calcium mobilization and phospholipase C activation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Chromatography, Gel; Enzyme Activation; Humans; In Vitro Techniques; Phthalic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptors, Thromboxane; Thrombin; Thromboxane A2; Type C Phospholipases | 1994 |
Effect of plasma fibrinogen concentration on the inhibition of platelet aggregation after ticlopidine compared with aspirin.
Topics: Adenosine Diphosphate; Aged; Aspirin; Cerebral Infarction; Cerebrovascular Disorders; Collagen; Female; Fibrinogen; Humans; Male; Platelet Aggregation; Platelet Count; Ticlopidine | 1994 |
Effect of single oral dose of aspirin on human platelet functions and plasma plasminogen activator inhibitor-1.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Epinephrine; Female; Fibrinogen; Humans; In Vitro Techniques; Male; Plasminogen Activator Inhibitor 1; Platelet Aggregation; Time Factors | 1993 |
Triterpenes and B-sitosterol from piper betle: isolation, antiplatelet and anti-inflammatory effects.
Topics: Adenosine Diphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Areca; Aspirin; Chromatography, Liquid; Edema; Humans; Plants, Medicinal; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Sitosterols; Triterpenes | 1993 |
Effect of aspirin and clopidogrel on platelet-dependent tissue factor expression in endothelial cells.
Topics: Adenosine Diphosphate; Animals; Aorta; Aspirin; Blood Platelets; Cattle; Clopidogrel; Endothelium, Vascular; Female; Ligation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Thionucleotides; Thrombin; Thromboplastin; Thrombosis; Ticlopidine; Vena Cava, Inferior | 1994 |
Coordinated inhibition of actin-induced platelet aggregation by plasma gelsolin and vitamin D-binding protein.
Topics: Actins; Adenosine; Adenosine Diphosphate; Animals; Apyrase; Aspirin; Dose-Response Relationship, Drug; Gelsolin; Humans; Kinetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Vitamin D-Binding Protein | 1993 |
Impact of treatment with acetylsalicylic acid on the proaggregatory effects of adrenaline in vitro in patients with stable angina pectoris: influence of the anticoagulant.
Topics: Adenosine Diphosphate; Angina Pectoris; Aspirin; Citrates; Drug Synergism; Epinephrine; Female; Hirudin Therapy; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count | 1993 |
Platelet aggregometry can accurately predict failure of externally supported knitted Dacron femoropopliteal bypass grafts.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Amputation, Surgical; Anastomosis, Surgical; Aspirin; Blood Vessel Prosthesis; Citrates; Citric Acid; Female; Femoral Artery; Follow-Up Studies; Forecasting; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Count; Polyethylene Terephthalates; Popliteal Artery; Prosthesis Failure; Regional Blood Flow; Risk Factors; Vascular Patency | 1993 |
Roles of phospholipase C and Ca(2+)-ATPase in calcium responses of single, fibrinogen-bound platelets.
Topics: Adenosine Diphosphate; Apyrase; Aspirin; Blood Platelets; Calcium; Calcium-Transporting ATPases; Cytosol; Egtazic Acid; Fibrinogen; Fura-2; Humans; Inositol Phosphates; Kinetics; Platelet Activation; Spectrometry, Fluorescence; Terpenes; Thapsigargin; Thrombin; Type C Phospholipases; Video Recording | 1993 |
The influence of aspirin on plasma and platelet catecholamine levels, and platelet function in normal man.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Catecholamines; Collagen; Epinephrine; Female; Humans; Male; Norepinephrine; Platelet Aggregation; Platelet Function Tests; Thromboxane B2 | 1993 |
Sodium fluoride induced activation of phospholipase C in intact human platelets does not depend on ADP, PAF or arachidonate products.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Enzyme Activation; GTP-Binding Proteins; Humans; Lysine; Phospholipid Ethers; Platelet Activating Factor; Sodium Fluoride; Type C Phospholipases | 1993 |
Platelet activation and thrombosis: studies in a patient with essential thrombocythemia.
Topics: Adenosine Diphosphate; Adult; Antibodies, Monoclonal; Aspirin; Blood Platelets; Disease Susceptibility; Female; Fibrinogen; Flow Cytometry; Humans; Mesenteric Arteries; Mesenteric Vascular Occlusion; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Portal Vein; Receptors, Purinergic P2; Splenic Vein; Thrombocythemia, Essential; Thrombosis; Ticlopidine | 1996 |
Effect of KBT-3022, a new diphenylthiazole derivative, on platelet functions.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Edema; Erythema; Gastric Mucosa; Guinea Pigs; Humans; Mice; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Rats; Serotonin; Species Specificity; Thiazoles; Thrombin; Ultraviolet Rays | 1995 |
[Effect of acetylsalicylic acid on platelet aggregation and capillary bleeding in healthy cats].
Topics: Adenosine Diphosphate; Animals; Aspirin; Capillaries; Cats; Collagen; Dose-Response Relationship, Drug; Hemorrhage; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Thrombin | 1995 |
Activation of receptor-operated cation channels via P2X1 not P2T purinoceptors in human platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Apyrase; Aspirin; Blood Platelets; Calcium; Calcium Channels; Fluorescent Dyes; Fura-2; Humans; In Vitro Techniques; Membrane Potentials; Membrane Proteins; Patch-Clamp Techniques; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2Y12 | 1996 |
Conditions influencing release of granule contents from human platelets in citrated plasma induced by ADP or the thrombin receptor activating peptide SFLLRN: direct measurement of percent release of beta-thromboglobulin and assessment by flow cytometry of
Topics: Adenosine Diphosphate; Aspirin; beta-Thromboglobulin; Blood Platelets; Citrates; Citric Acid; Cytoplasmic Granules; Flow Cytometry; Humans; P-Selectin; Peptide Fragments; Plasma; Receptors, Thrombin; Serotonin | 1996 |
Involvement of mercury in platelet aggregation--probable mechanism of action.
Topics: Adenosine Diphosphate; Animals; Aspirin; Cyclic AMP; Cyclooxygenase Inhibitors; Male; Mercuric Chloride; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Theophylline | 1996 |
High shear-induced platelet activation and inactivation: the importance of methodology.
Topics: Adenosine Diphosphate; Anticoagulants; Aspirin; Hemorheology; Hot Temperature; Humans; Platelet Activation; Platelet Function Tests; Pressure | 1996 |
[Erythrocytes modulate the anti-aggregation effect of aspirin and dipyridamole. Study under static conditions and in a flow system].
Topics: Adenosine Diphosphate; Aspirin; Erythrocytes; Hemorheology; Humans; Models, Biological; Perfusion; Platelet Aggregation; Platelet Aggregation Inhibitors | 1996 |
The efficacy and potency of antiplatelet activity of ticlopidine is increased by aspirin.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Collagen; Drug Synergism; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 1996 |
Platelet function and platelet-leukocyte adhesion in symptomatic coronary heart disease. Effects of intravenous magnesium.
Topics: Adenosine Diphosphate; Adult; Aged; Angina Pectoris; Aspirin; Cell Adhesion; Coronary Disease; Dose-Response Relationship, Drug; Female; Humans; Injections, Intravenous; Leukocytes; Magnesium; Male; Middle Aged; Neutrophils; P-Selectin; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Thrombosis | 1996 |
Enhanced increases in cytosolic Ca2+ in ADP-stimulated platelets from patients with delta-storage pool deficiency--a possible indicator of interactions between granule-bound ADP and the membrane ADP receptor.
Topics: Adenosine Diphosphate; Apyrase; Aspirin; Blood Platelets; Blood Specimen Collection; Calcium; Cytoplasmic Granules; Cytosol; Humans; Platelet Storage Pool Deficiency; Receptors, Purinergic P2; Serotonin; Thrombin | 1997 |
Aggregation of human blood platelets by remnant like lipoprotein particles of plasma chylomicrons and very low density lipoproteins.
Topics: Adenosine Diphosphate; Adult; Antibodies, Monoclonal; Aspirin; Blood Platelets; Chromatography, Affinity; Chylomicrons; Cilostazol; Erythrocyte Membrane; Hematocrit; Humans; In Vitro Techniques; Lipoproteins; Lipoproteins, VLDL; Male; Microscopy, Electron, Scanning; Middle Aged; Peptide Fragments; Phosphodiesterase Inhibitors; Platelet Adhesiveness; Platelet Aggregation; Tetrazoles | 1997 |
Characteristics of protein kinase C-independent exocytosis in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Blood Platelets; Exocytosis; Humans; Indoles; Maleimides; Molecular Weight; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Thromboxane B2; Vasoconstrictor Agents | 1997 |
Comparison of enoxaparin, hirulog, and heparin as adjunctive antithrombotic therapy during thrombolysis with rtPA in the stenosed canine coronary artery.
Topics: Adenosine Diphosphate; Animals; Aspirin; Bleeding Time; Collagen; Coronary Thrombosis; Dogs; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Enoxaparin; Factor Xa Inhibitors; Female; Fibrinolytic Agents; Hemorrhage; Hemostasis; Heparin; Hirudin Therapy; Hirudins; Male; Partial Thromboplastin Time; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prothrombin; Prothrombin Time; Recombinant Proteins; Recurrence; Safety; Thrombin; Thrombolytic Therapy; Tissue Plasminogen Activator | 1997 |
The Ca2+-mobilizing potency of alpha-thrombin and thrombin-receptor-activating peptide on human platelets -- concentration and time effects of thrombin-induced Ca2+ signaling.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Apyrase; Aspirin; Blood Platelets; Calcium; Cytosol; Egtazic Acid; Humans; In Vitro Techniques; Kinetics; Peptide Fragments; Platelet Activation; Receptors, Thrombin; Signal Transduction; Thrombin; Time Factors | 1997 |
Depressed platelet status in an elderly patient with hemorrhagic stroke after thrombolysis for acute myocardial infarction. GUSTO-III Investigators.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Antigens, CD; Aspirin; Blood Platelets; Cerebral Hemorrhage; Cerebrovascular Disorders; Collagen; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Follow-Up Studies; Humans; Male; Membrane Glycoproteins; Myocardial Infarction; P-Selectin; Paraplegia; Plasminogen Activators; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Endothelial Cell Adhesion Molecule-1; Platelet Membrane Glycoproteins; Prospective Studies; Receptors, Very Late Antigen; Ristocetin; Tetraspanin 29; Thrombin; Thrombolytic Therapy; Tissue Plasminogen Activator; Vitronectin | 1998 |
Apo E4/3-rich remnant lipoproteins and platelet aggregation: a case report.
Topics: 2-Chloroadenosine; Adenosine Diphosphate; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Aspirin; Blood Platelets; Cardiovascular Diseases; Cilostazol; Death, Sudden, Cardiac; Disease Susceptibility; Dose-Response Relationship, Drug; Heterozygote; Humans; Lipoproteins; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Tetrazoles | 1998 |
Difference of (Ca2+)i movements in platelets stimulated by thrombin and TRAP: the involvement of alpha(IIb)beta3-mediated TXA2 synthesis.
Topics: Adenosine Diphosphate; Antibodies, Monoclonal; Apyrase; Aspirin; Blood Platelets; Calcium; Cyclooxygenase Inhibitors; Dipeptides; Fibrinogen; Humans; Ion Transport; Peptide Fragments; Phenylacetates; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Thrombin; Signal Transduction; Sulfonamides; Thrombin; Thromboxane A2; Thromboxane B2; Tirofiban; Tyrosine | 1998 |
Antecedent aspirin therapy inhibits baseline platelet activity in patients presenting with acute myocardial infarction. The GUSTO-III Platelet Substudy.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Male; Middle Aged; Myocardial Infarction; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Endothelial Cell Adhesion Molecule-1; Receptors, Cell Surface; Thrombolytic Therapy | 1998 |
ADP, adrenaline and serotonin stimulate inositol 1,4,5-trisphosphate production in human platelets.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Calcium; Drug Synergism; Epinephrine; Humans; Inositol 1,4,5-Trisphosphate; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin | 1998 |
Augmented platelet aggregation as predictor of reocclusion after thrombolysis in acute myocardial infarction.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Anticoagulants; Antithrombin III; Aspirin; Coronary Vessels; Diabetes Mellitus; Drug Therapy, Combination; Female; Fibrinolysis; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Obesity; Peptide Fragments; Peptide Hydrolases; Plasminogen Activator Inhibitor 1; Plasminogen Activators; Platelet Aggregation; Predictive Value of Tests; Prothrombin; Recombinant Proteins; Recurrence; Risk Factors; Smoking; Thrombolytic Therapy; Tissue Plasminogen Activator; Vascular Patency | 1998 |
Differential effects of three radiographic contrast media on platelet aggregation and degranulation: implications for clinical practice?
Topics: Adenosine Diphosphate; Antithrombins; Aspirin; Cell Degranulation; Contrast Media; Hirudins; Humans; Iopamidol; Ioxaglic Acid; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Triiodobenzoic Acids | 1998 |
[Method of quantitative measurement of human platelet aggregation in clinical practice].
Topics: Adenosine Diphosphate; Adult; Aged; Aspirin; Dipyridamole; Epinephrine; Female; Humans; Male; Methods; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Trapidil | 1998 |
Antiaggregatory, antithrombotic effects of MS-180, a novel platelet glycoprotein IIb/IIIa receptor antagonist.
Topics: Acetates; Adenosine Diphosphate; Anesthesia; Animals; Aspirin; Benzopyrans; Bleeding Time; Blood Platelets; Collagen; Dogs; Dose-Response Relationship, Drug; Fibrinolytic Agents; Glycoproteins; Guinea Pigs; Humans; In Vitro Techniques; Morpholines; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Binding | 1999 |
The lack of augmentation by aspirin of inhibition of platelet reactivity by ticlopidine.
Topics: Adenosine Diphosphate; Adult; Analysis of Variance; Anticoagulants; Aspirin; Chemoprevention; Citric Acid; Collagen; Drug Interactions; Enoxaparin; Factor XIIa; Flow Cytometry; Humans; Male; P-Selectin; Plant Proteins; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Trypsin Inhibitors; Zea mays | 1999 |
Inhibitory effect of sulfur-containing compounds in Scorodocarpus borneensis Becc. on the aggregation of rabbit platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Coagulation Factors; Collagen; Hemostatics; Hexanes; Inhibitory Concentration 50; Octanes; Plant Extracts; Plants, Edible; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Sulfur Compounds; Thrombin; Trees; Vasoconstrictor Agents | 1999 |
The role of melatonin in pathogenesis of aspirin-sensitive asthma.
Topics: Adenosine Diphosphate; Adolescent; Aspirin; Asthma; Blood Platelets; Circadian Rhythm; Female; Humans; In Vitro Techniques; Male; Melatonin; Middle Aged; Platelet Aggregation; Reference Values | 1999 |
Clopidogrel: a novel antiplatelet agent.
Topics: Adenosine Diphosphate; Aspirin; Clopidogrel; Humans; Ischemia; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; Vascular Diseases | 1999 |
Effects of sodium selenite on in vitro interactions between platelets and endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Aspirin; Blood Platelets; Cells, Cultured; Culture Media, Conditioned; Endothelium, Vascular; Enzyme Activation; Glutathione Peroxidase; Humans; Nitric Oxide; Platelet Aggregation; Selenium; Sodium Selenite; Thromboxane A2; Thromboxane B2 | 1999 |
Inhibitory effects of H2-receptor antagonists on platelet function in vitro.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cimetidine; Collagen; Famotidine; Female; Heterocyclic Compounds, 1-Ring; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Middle Aged; P-Selectin; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Ranitidine; Structure-Activity Relationship | 1999 |
Concomitant activation of Gi protein-coupled receptor and protein kinase C or phospholipase C is required for platelet aggregation.
Topics: Adenosine Diphosphate; Aspirin; Chelating Agents; Crotalid Venoms; Egtazic Acid; Enzyme Activation; Epinephrine; GTP-Binding Proteins; Humans; Indoles; Lectins, C-Type; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1999 |
Antithrombotic activities of green tea catechins and (-)-epigallocatechin gallate.
Topics: Adenosine Diphosphate; Animals; Aspirin; Bleeding Time; Calcimycin; Calcium; Catechin; Collagen; Epinephrine; Fibrinolytic Agents; Humans; Ion Transport; Ionophores; Male; Mice; Mice, Inbred ICR; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Rats; Rats, Sprague-Dawley; Tea | 1999 |
Platelet GP IIIa Pl(A) polymorphisms display different sensitivities to agonists.
Topics: Abciximab; Adenosine Diphosphate; Adult; Amino Acid Substitution; Antibodies, Monoclonal; Aspirin; Blood Platelets; Cell Membrane; Dose-Response Relationship, Drug; Female; Fibrinogen; Gene Dosage; Genotype; Humans; Immunoglobulin Fab Fragments; Male; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Reference Values | 2000 |
Antiplatelet and antithrombotic effects of orbofiban, a new orally active GPIIb/IIIa antagonist, in guinea pigs.
Topics: Adenosine Diphosphate; Administration, Oral; Alanine; Animals; Arteriovenous Shunt, Surgical; Aspirin; beta-Alanine; Bleeding Time; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Guinea Pigs; Hemostasis; Hypercholesterolemia; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyrrolidines; Thrombosis; Urea | 2000 |
In vivo dynamic real-time monitoring and quantification of platelet-thrombus formation: use of a local isotope detector.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Anticoagulants; Aspirin; Blood Platelets; Carotid Arteries; Carotid Artery Injuries; Computer Systems; Fibrinolytic Agents; Gene Expression; Heparin; Indium Radioisotopes; Partial Thromboplastin Time; Plasminogen Activator Inhibitor 1; Radionuclide Imaging; RNA, Messenger; Swine; Thrombosis; Ultrasonography, Doppler; Uridine Diphosphate; Uridine Triphosphate | 2000 |
Characteristics of collagen-induced Ca2+ mobilization in bovine platelets.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Cattle; Collagen; Egtazic Acid; Enzyme Inhibitors; Estrenes; Fluorescent Dyes; Fura-2; Humans; Manganese; Phosphoadenosine Phosphosulfate; Platelet Aggregation Inhibitors; Pyrrolidinones; Thapsigargin; Thrombin; Type C Phospholipases | 2000 |
The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Blood Platelets; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Platelet Activation; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2Y1; Signal Transduction; Thromboxane A2; Vasoconstrictor Agents | 2000 |
Antithrombotic effect of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, on platelet plug formation in in vivo experiments.
Topics: Adenosine Diphosphate; Alkaloids; Animals; Aspirin; Bleeding Time; Blood Pressure; Drugs, Chinese Herbal; Fluorescein; Indole Alkaloids; Mice; Mice, Inbred ICR; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Quinazolines; Rats; Rats, Sprague-Dawley | 2000 |
Effect of aspirin on platelet desaggregation induced by SR121566, a potent GP-IIb/IIIa antagonist.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Benzylamines; Blood Flow Velocity; Blood Platelets; Carotid Arteries; Disease Models, Animal; Electric Stimulation; Female; Fibrinolytic Agents; Humans; Male; Oligopeptides; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Recombinant Proteins; Thiazoles; Thrombosis; Thrombospondins; Tissue Plasminogen Activator | 2000 |
Habitual smoking causes an abnormality in platelet thromboxane A2 metabolism and results in an altered susceptibility to aspirin effects.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Aspirin; Blood Platelets; Collagen; Epoprostenol; Erythrocytes; Humans; Male; Platelet Aggregation; Smoking; Thromboxane A2; Thromboxanes | 2000 |
Effects of acetyl salicylic acid therapy on an experimental thrombosis induced by laser beam.
Topics: Adenosine Diphosphate; Animals; Aspirin; Bleeding Time; Disease Models, Animal; Fibrinogen; Lasers; Male; Partial Thromboplastin Time; Platelet Aggregation; Rats; Rats, Wistar; Thrombosis | 2000 |
Defective platelet response to arachidonic acid and thromboxane A(2) in subjects with Pl(A2) polymorphism of beta(3) subunit (glycoprotein IIIa).
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; beta-Thromboglobulin; Blood Platelets; Coronary Disease; Female; Flow Cytometry; Genotype; Humans; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Risk Factors; Statistics, Nonparametric; Thrombin; Thromboxane A2 | 2000 |
The central role of the P(2T) receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Analysis of Variance; Annexin A5; Aspirin; Blood Platelets; Calcium; Collagen; Cytosol; Fibrinolytic Agents; Flow Cytometry; Humans; Membrane Proteins; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Serotonin; Stimulation, Chemical; Thromboxane A2 | 2000 |
Abciximab treatment in vitro after aspirin treatment in vivo has additive effects on platelet aggregation, ATP release, and P-selectin expression.
Topics: Abciximab; Adenosine Diphosphate; Adenosine Triphosphate; Adult; Antibodies, Monoclonal; Arachidonic Acid; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors | 2000 |
Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor.
Topics: Adenosine Diphosphate; Amidohydrolases; Arachidonic Acids; Aspirin; Biological Transport; Blood Platelets; Calcium Channel Blockers; Camphanes; Cannabinoid Receptor Modulators; Collagen; Cyclic AMP; Endocannabinoids; Glycerides; Humans; Hydrolysis; Inositol 1,4,5-Trisphosphate; Kinetics; Piperidines; Platelet Activation; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin; Time Factors | 2001 |
Characterization of whole blood aggregation with a new type of aggregometer by a screen filtration pressure method.
Topics: Adenosine Diphosphate; Aspirin; Collagen; Equipment Design; Filtration; Humans; Platelet Aggregation; Platelet Function Tests; Pressure; Reproducibility of Results | 2001 |
Antithrombotic effects of tetramethylpyrazine in in vivo experiments.
Topics: Acute Disease; Adenosine Diphosphate; Animals; Aspirin; Bleeding Time; Blood Pressure; Drug Evaluation, Preclinical; Fibrinolytic Agents; Injections, Intravenous; Mesenteric Arteries; Mesenteric Veins; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Pyrazines; Radiation Injuries, Experimental; Reproducibility of Results; Thrombolytic Therapy; Vasodilator Agents; Venous Thrombosis | 2001 |
Estimation of anti-platelet drugs on human platelet aggregation with a novel whole blood aggregometer by a screen filtration pressure method.
Topics: Adenosine Diphosphate; Amino Acid Chloromethyl Ketones; Aspirin; Blood Coagulation; Blood Platelets; Cilostazol; Collagen; Dipyridamole; Filtration; Heparin; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Pressure; Tetrazoles; Time Factors; Tirofiban; Tyrosine | 2001 |
Effects of combining three different antiplatelet agents on platelets and leukocytes in whole blood in vitro.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aspirin; Blood Platelets; Cell Communication; Dipyridamole; Drug Synergism; Flow Cytometry; Humans; Leukocytes; Macrophage-1 Antigen; Monocytes; Neutrophils; P-Selectin; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors | 2001 |
Increased platelet glycoprotein V levels in patients with coronary and peripheral atherosclerosis--the influence of aspirin and cigarette smoking.
Topics: Adenosine Diphosphate; Adult; Aged; Arteriosclerosis; Aspirin; beta-Thromboglobulin; Biomarkers; Cholesterol, HDL; Collagen; Coronary Artery Disease; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Epinephrine; Female; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Multivariate Analysis; Platelet Activation; Platelet Glycoprotein GPIb-IX Complex; Risk Factors; Smoking | 2001 |
The hepoxilin analog PBT-3 inhibits heparin-activated platelet aggregation evoked by ADP.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Diphosphate; Anticoagulants; Arachidonic Acids; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fatty Acids, Unsaturated; Heparin; Humans; Hydrazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2 | 2002 |
Antithrombotic effect of PMC, a potent alpha-tocopherol analogue on platelet plug formation in vivo.
Topics: Adenosine Diphosphate; Animals; Antioxidants; Aspirin; Bleeding Time; Blood Pressure; Chromans; Fluorescein; Mesenteric Arteries; Mice; Mice, Inbred ICR; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Rats; Rats, Sprague-Dawley; Thrombosis | 2002 |
Evaluation of platelets in heart failure: is platelet activity related to etiology, functional class, or clinical outcomes?
Topics: Adenosine Diphosphate; Aged; Anticoagulants; Aspirin; Female; Heart Failure; Humans; Male; Middle Aged; Pilot Projects; Platelet Activation; Platelet Aggregation; Prospective Studies | 2002 |
An additional mechanism of action of abciximab: dispersal of newly formed platelet aggregates.
Topics: Abciximab; Adenosine Diphosphate; Antibodies, Monoclonal; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Drug Synergism; Fibrinogen; Humans; Immunoglobulin Fab Fragments; Kinetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding | 2002 |
Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica.
Topics: Adenosine Diphosphate; Alkaloids; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Diterpenes; Female; Fibrinolytic Agents; Ginkgolides; In Vitro Techniques; Indicators and Reagents; Lactones; Male; Plant Extracts; Plant Roots; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rabbits; Spiraea | 2002 |
Association of aortic stenosis with platelet hyperaggregability and impaired responsiveness to nitric oxide.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aortic Valve Stenosis; Aspirin; Cardiovascular Agents; Coronary Artery Disease; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitric Oxide; Nitroprusside; Perhexiline; Platelet Aggregation; Platelet Aggregation Inhibitors; Severity of Illness Index; Statistics as Topic; Stroke Volume; Ventricular Function, Left | 2002 |
Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aspirin; Blood Platelets; Cell Adhesion; Clopidogrel; Drug Therapy, Combination; Female; Humans; Leukocytes; Male; Membrane Proteins; Middle Aged; Myocardial Ischemia; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Stents; Ticlopidine | 2002 |
Effect of increasing doses of aspirin on platelet aggregation among stroke patients.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Stroke | 2002 |
Resistance to aspirin in vitro is associated with increased platelet sensitivity to adenosine diphosphate.
Topics: Adenosine Diphosphate; Aged; Angina Pectoris; Aspirin; Blood Platelets; Case-Control Studies; Coronary Artery Disease; Drug Resistance; Dual Specificity Phosphatase 2; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Function Tests; Protein Phosphatase 2; Protein Tyrosine Phosphatases | 2002 |
Antiplatelet effects of angiotensin-converting enzyme inhibitors compared with aspirin and clopidogrel: a pilot study with whole-blood aggregometry.
Topics: Adenosine Diphosphate; Adult; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Case-Control Studies; Clopidogrel; Coronary Disease; Female; Humans; Hypertension; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2003 |
Value of thromboelastography in the assessment of platelet function.
Topics: Adenosine Diphosphate; Aspirin; Humans; Peripheral Vascular Diseases; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Sensitivity and Specificity; Thrombelastography; Tirofiban; Tyrosine | 2003 |
Obesity is associated with impaired platelet-inhibitory effect of acetylsalicylic acid in nondiabetic subjects.
Topics: Adenosine Diphosphate; Analysis of Variance; Arachidonic Acid; Arteriosclerosis; Aspirin; Blood Glucose; Body Mass Index; Body Weight; Dose-Response Relationship, Drug; Female; Humans; Insulin Resistance; Male; Middle Aged; Obesity; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors | 2003 |
[Platelets and arterial thrombosis].
Topics: Adenosine Diphosphate; Angioplasty, Balloon; Anti-Bacterial Agents; Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Blood Platelets; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Thrombin; Thrombosis | 2003 |
The anti-leukemic Bruton's tyrosine kinase inhibitor alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl) propenamide (LFM-A13) prevents fatal thromboembolism.
Topics: Adenosine Diphosphate; Agammaglobulinaemia Tyrosine Kinase; Amides; Animals; Aspirin; Bleeding Time; Catalytic Domain; Collagen; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fibrinolytic Agents; Humans; Janus Kinase 3; Male; Mice; Mice, Inbred ICR; Nitriles; Peptide Fragments; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Pulmonary Embolism; Quinazolines; Receptors, Collagen; Signal Transduction; Thrombin; Thromboembolism; Thromboplastin | 2003 |
Increased sensitivity to ADP-aggregation in aspirin treated patients with recurrent ischemic stroke?
Topics: Adenosine Diphosphate; Aspirin; Female; Humans; Male; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk; Secondary Prevention; Stroke | 2003 |
Comparison of turbidimetric aggregation and in vitro bleeding time (PFA-100) for monitoring the platelet inhibitory profile of antiplatelet agents in patients undergoing stent implantation.
Topics: Abciximab; Adenosine Diphosphate; Aged; Angina Pectoris; Antibodies, Monoclonal; Aspirin; Bleeding Time; Clopidogrel; Collagen; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Ticlopidine; Time Factors | 2003 |
Increased platelet CD63 and P-selectin expression persist in atherosclerotic ischemic stroke.
Topics: Adenosine Diphosphate; Aged; Anticoagulants; Antigens, CD; Aspirin; Blood Platelets; Brain Ischemia; Clopidogrel; Collagen; Female; Flow Cytometry; Heparin; Humans; Intracranial Arteriosclerosis; Lipids; Male; Middle Aged; P-Selectin; Patient Selection; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins; Stroke; Tetraspanin 30; Ticlopidine; Time Factors | 2004 |
Inhibition of platelet aggregation by aspirin progressively decreases in long-term treated patients.
Topics: Adenosine Diphosphate; Aged; Aspirin; Collagen; Female; Humans; Longitudinal Studies; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Activated human platelets release connective tissue growth factor.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Blotting, Western; Bone Marrow; Connective Tissue Growth Factor; Cytoplasmic Granules; Humans; Immediate-Early Proteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Megakaryocytes; Platelet Activation; Thrombin | 2004 |
Evaluation of effects of rofecoxib on platelet function in an in vitro model of thrombosis with circulating human blood.
Topics: Adenosine Diphosphate; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Cell Adhesion; Collagen; Cyclooxygenase Inhibitors; Endothelium; Humans; Lactones; Platelet Aggregation; Sulfones; Thrombosis | 2004 |
Evaluation of anti-platelet aggregatory effects of aspirin, cilostazol and ramatroban on platelet-rich plasma and whole blood.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Carbazoles; Cilostazol; Collagen; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclooxygenase Inhibitors; Humans; Microscopy, Confocal; Phosphodiesterase Inhibitors; Plasma; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thromboxane A2, Prostaglandin H2; Reproducibility of Results; Sulfonamides; Tetrazoles | 2004 |
The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Cell Shape; Collagen; Drug Synergism; GTP-Binding Protein alpha Subunits, Gq-G11; Kinetics; Mice; Mice, Knockout; Microscopy, Electron, Scanning; Platelet Activation; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; Thromboxane A2 | 2004 |
PlA polymorphism and platelet reactivity following clopidogrel loading dose in patients undergoing coronary stent implantation.
Topics: Abciximab; Adenosine Diphosphate; Aged; Amino Acid Substitution; Antibodies, Monoclonal; Aspirin; Blood Platelets; Clopidogrel; Coronary Thrombosis; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Heterozygote; Homozygote; Humans; Immunoglobulin Fab Fragments; Integrin beta3; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Stents; Ticlopidine; Treatment Outcome | 2004 |
Pharmacodynamic profile of antiplatelet agents: marked differences between single versus costimulation with platelet activators.
Topics: Abciximab; Adenosine Diphosphate; Adenosine Monophosphate; Antibodies, Monoclonal; Aspirin; Blood Platelets; Cell Degranulation; Collagen; Drug Interactions; Humans; Immunoglobulin Fab Fragments; Membrane Proteins; Oligopeptides; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12 | 2004 |
Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction.
Topics: Adenosine Diphosphate; Aged; Aspirin; Biotransformation; Clopidogrel; Combined Modality Therapy; Coronary Artery Disease; Coronary Restenosis; Coronary Thrombosis; Drug Resistance; Drug Therapy, Combination; Epinephrine; Eptifibatide; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Prospective Studies; Purinergic P2 Receptor Antagonists; Recurrence; Risk; Smoking; Stents; Ticlopidine; Treatment Outcome | 2004 |
Mechanism of activation of ADP-induced platelet aggregation under the influence of oxidatively modified fibrinogen.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Aspirin; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Estrenes; Fibrinogen; Genistein; Humans; In Vitro Techniques; Oxidation-Reduction; Platelet Aggregation; Protein Kinase C; Protein-Tyrosine Kinases; Pyrrolidinones; Type C Phospholipases; Ultraviolet Rays | 2004 |
Platelet function predicts myocardial damage in patients with acute myocardial infarction.
Topics: Abciximab; Adenosine Diphosphate; Aged; Antibodies, Monoclonal; Anticoagulants; Aspirin; Cardiovascular Agents; Clopidogrel; Collagen; Comorbidity; Eptifibatide; Female; Humans; Immunoglobulin Fab Fragments; Leukocyte Count; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Myocardium; Necrosis; Peptides; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Ticlopidine; Tirofiban; Tyrosine; von Willebrand Factor | 2004 |
[Assessment of speed of an anti-platelet effect after two different doses of acetylsalicylic acid by flocculation].
Topics: Adenosine Diphosphate; Adult; Aspirin; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ristocetin | 2004 |
Effects of a novel platelet nitric oxide donor (LA816), aspirin, clopidogrel, and combined therapy in inhibiting flow- and lesion-dependent thrombosis in the porcine ex vivo model.
Topics: Adenosine Diphosphate; Amino Acids; Animals; Aspirin; Benzoates; Blood Pressure; Clopidogrel; Collagen; Cyclooxygenase Inhibitors; Drug Evaluation; Drug Therapy, Combination; Fibrinolytic Agents; Free Radical Scavengers; Guanylate Cyclase; Heart Rate; Hemorheology; Imidazoles; Membrane Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Quinoxalines; Random Allocation; Receptors, Purinergic P2Y12; rhoA GTP-Binding Protein; Sus scrofa; Thrombosis; Ticlopidine | 2004 |
Selective inhibition of cyclooxygenase-2 enhances platelet adhesion in hamster arterioles in vivo.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Animals; Arterioles; Aspirin; Cells, Cultured; Cricetinae; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelial Cells; Endothelium, Vascular; Humans; Iloprost; Membrane Proteins; Mesocricetus; Nitrobenzenes; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Skin Window Technique; Sulfonamides; Thrombophilia; Umbilical Veins | 2004 |
Acetylsalicylic acid inhibits ATP diphosphohydrolase activity by platelets from adult rats.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Apyrase; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; In Vitro Techniques; Male; Rats; Rosaniline Dyes | 2004 |
Potentiation of platelet aggregation by heparin in human whole blood is attenuated by P2Y12 and P2Y1 antagonists but not aspirin.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aspirin; Blood Platelets; Cell Degranulation; Dalteparin; Drug Synergism; Heparin; Hirudins; Humans; In Vitro Techniques; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12 | 2005 |
Immune heparin-induced thrombocytopenia can occur in patients receiving clopidogrel and aspirin.
Topics: Adenosine Diphosphate; Adult; Aged; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clopidogrel; Female; Heparin; Humans; Immunoenzyme Techniques; Male; Platelet Activation; Platelet Factor 4; Thrombocytopenia; Thrombolytic Therapy; Ticlopidine | 2005 |
P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose.
Topics: Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Coronary Disease; Female; Genotype; Haplotypes; Humans; Male; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Cell Surface; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2005 |
P2Y12 ADP receptor-dependent tyrosine phosphorylation of proteins of 27 and 31 kDa in thrombin-stimulated human platelets.
Topics: Adenine; Adenosine Diphosphate; Adenosine Monophosphate; Adenylyl Cyclases; Aspirin; Blood Platelets; Collagen; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epinephrine; Epoprostenol; Humans; Membrane Proteins; Oligopeptides; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Signal Transduction; Thrombin; Time Factors; Tyrosine | 2005 |
Assessment of the antiplatelet effects of low to medium dose aspirin in the early and late phases after ischaemic stroke and TIA.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Case-Control Studies; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Epinephrine; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandin-Endoperoxide Synthases; Stroke; von Willebrand Factor | 2005 |
A new point-of-care method for monitoring anti-platelet therapy: application of the cone and plate(let) analyzer.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Proteins; Drug Monitoring; Humans; Membrane Proteins; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Sensitivity and Specificity | 2005 |
Flow cytometric measurement of platelet-leukocyte aggregates: a possible target to monitor platelet function?
Topics: Adenosine Diphosphate; Adult; Arterial Occlusive Diseases; Aspirin; Blood Platelets; Clopidogrel; Flow Cytometry; Heart Diseases; Humans; Leukocytes; Male; Monocytes; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk; Ticlopidine | 2005 |
Role of the retention test Homburg in evaluating platelet hyperactivity and in monitoring therapy with antiplatelet drugs.
Topics: Abciximab; Adenosine Diphosphate; Antibodies, Monoclonal; Aspirin; Blood Platelets; Cell Shape; Clopidogrel; Collagen; Drug Monitoring; Humans; Immunoglobulin Fab Fragments; P-Selectin; Pilot Projects; Plasma; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Prostaglandins; Ristocetin; Ticlopidine | 2005 |
Platelet aggregation in portal hypertension and its modification by ultra-low doses of aspirin.
Topics: Adenosine Diphosphate; Animals; Aspirin; Fibrinogen; Hemorrhage; Humans; Hypertension, Portal; Injections, Subcutaneous; Male; Partial Thromboplastin Time; Platelet Aggregation; Platelet Aggregation Inhibitors; Prothrombin Time; Rats; Rats, Wistar | 2005 |
Platelet emboli and ischemia in rabbit's brain caused by ADP or arachidonic acid and the protective effect of ASA and dipyridamole.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Dipyridamole; Intracranial Embolism; Ischemic Attack, Transient; Male; Pia Mater; Platelet Aggregation; Rabbits | 1977 |
Influence of aspirin resistance on platelet function profiles in patients on long-term aspirin and clopidogrel after percutaneous coronary intervention.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Collagen Type I; Diabetes Mellitus; Drug Resistance; Drug Therapy, Combination; Epinephrine; Female; Flow Cytometry; Humans; Male; Middle Aged; P-Selectin; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Vasoconstrictor Agents | 2006 |
Differential antiplatelet effects of angiotensin converting enzyme inhibitors: comparison of ex vivo platelet aggregation in cardiovascular patients with ramipril, captopril and enalapril.
Topics: Adenosine Diphosphate; Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Captopril; Cardiovascular Diseases; Clopidogrel; Collagen; Coronary Artery Disease; Electric Impedance; Enalapril; Female; Fibrinolytic Agents; Germany; Humans; Hypertension; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ramipril; Ticlopidine; Treatment Outcome | 2006 |
Usefulness of whole blood aggregometry and its comparison with thromboxane generation assay in monitoring acetylsalicylic acid effectiveness--a multiparametric study in rats.
Topics: Adenosine Diphosphate; Animals; Aspirin; Biomarkers; Blood Platelets; Cell Aggregation; Collagen; Male; Nephelometry and Turbidimetry; Platelet Aggregation; Rats; Rats, Wistar; Thromboxanes; Time Factors | 2006 |
Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Clopidogrel; Coronary Artery Disease; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Resistance; Female; Flow Cytometry; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Signal Transduction; Thrombosis; Thromboxane B2; Ticlopidine; Time Factors; Treatment Refusal | 2006 |
Relation between atherosclerosis risk factors and aspirin resistance in a primary prevention population.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Coronary Artery Disease; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Thromboxane B2; Whole Blood Coagulation Time | 2006 |
Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood.
Topics: Adenosine Diphosphate; Anticoagulants; Apyrase; Aspirin; Blood Preservation; Citrates; Collagen; Dose-Response Relationship, Drug; Electric Impedance; Electrodes; Hirudins; Humans; In Vitro Techniques; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Sodium Citrate; Time Factors | 2006 |
Letter by Kronish et al regarding article, "Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance".
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Coronary Disease; Cyclooxygenase 1; Cyclooxygenase 2; Drug Resistance; Humans; Patient Compliance; Platelet Activation; Reproducibility of Results | 2007 |
High post-treatment platelet reactivity is associated with a high incidence of myonecrosis after stenting for non-ST elevation acute coronary syndromes.
Topics: Acute Disease; Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Female; France; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prognosis; Prospective Studies; Research Design; Risk Factors; Stents; Syndrome; Ticlopidine; Time Factors; Troponin I | 2007 |
Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Antibodies, Monoclonal; Aspirin; Atherosclerosis; Blood Coagulation Tests; Blood Platelets; Carotid Stenosis; Dose-Response Relationship, Drug; Hemorheology; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thrombosis; Time Factors; von Willebrand Factor | 2007 |
[Platelet responsiveness to clopidogrel in patients with coronary syndrome. Comparison of platelet aggregation induced by ADP and flow cytometric analysis of intraplatelet VASP phosphorylation].
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Blood Proteins; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Female; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Follow-Up Studies; Humans; Male; Microfilament Proteins; Myocardial Infarction; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Syndrome; Ticlopidine | 2007 |
The thrombolytic effect of aspirin in animal model.
Topics: Adenosine Diphosphate; Adult; Animals; Aspirin; Disease Models, Animal; Female; Fibrinolysis; Humans; Male; Middle Aged; Platelet-Rich Plasma; Thrombolytic Therapy; Thrombosis | 2007 |
Evaluation of the platelet response to clopidogrel with light transmittance aggregometry: peak aggregation or late aggregation?
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Hematologic Tests; Humans; Light; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Risk; Ticlopidine | 2007 |
Biomarker optimization to track the antithrombotic and hemostatic effects of clopidogrel in rats.
Topics: Adenosine Diphosphate; Animals; Aspirin; Biomarkers; Cell Adhesion Molecules; Clopidogrel; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hemostatics; Male; Membrane Proteins; Microfilament Proteins; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2007 |
[Interindividual variability in the laboratory response to the aspirin-clopidogrel combination: are patients with stent occlusion "resistant" to treatment?].
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Coronary Restenosis; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Ticlopidine | 2007 |
Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits.
Topics: Adenosine Diphosphate; Analysis of Variance; Animals; Aspirin; Biomarkers; Bleeding Time; Blood Platelets; Carotid Artery Thrombosis; Carotid Artery, Common; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Hemostasis; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Protein Binding; Rabbits; Receptors, Purinergic P2; Regional Blood Flow; Thromboxane B2; Ticlopidine | 2007 |
Modulation of ADP-induced platelet activation by aspirin and pravastatin: role of lectin-like oxidized low-density lipoprotein receptor-1, nitric oxide, oxidative stress, and inside-out integrin signaling.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Drug Therapy, Combination; Fibrinogen; Humans; Integrin alpha2beta1; Nitric Oxide; Oxidative Stress; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Pravastatin; Scavenger Receptors, Class E; Signal Transduction | 2007 |
Factors related to progression of middle cerebral artery stenosis determined using transcranial Doppler ultrasonograhy.
Topics: Adenosine Diphosphate; Aged; Aspirin; Cerebral Angiography; Clopidogrel; Constriction, Pathologic; Disease Progression; Female; Humans; Infarction, Middle Cerebral Artery; Logistic Models; Magnetic Resonance Angiography; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography, Doppler, Transcranial | 2008 |
Residual platelet reactivity is associated with clinical and laboratory characteristics in patients with ischemic heart disease undergoing PCI on dual antiplatelet therapy.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Myocardial Ischemia; Platelet Aggregation Inhibitors; Protein Isoforms; Risk Factors; Ticlopidine | 2007 |
The active metabolite of prasugrel inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: Influence of other blood cells, calcium, and aspirin.
Topics: Adenosine Diphosphate; Adult; Aspirin; Biomarkers; Blood Cells; Calcium; Cells, Cultured; Female; Humans; Inflammation; Kinetics; Male; Middle Aged; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Thiophenes; Thrombosis; Up-Regulation | 2007 |
Relationships between optical aggregometry (type born) and flow cytometry in evaluating ADP-induced platelet activation.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Dual Specificity Phosphatase 2; Female; Flow Cytometry; Humans; Image Cytometry; Male; Microfilament Proteins; Middle Aged; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Reproducibility of Results; Sensitivity and Specificity; Ticlopidine | 2008 |
Platelet activation, myocardial ischemic events and postoperative non-response to aspirin in patients undergoing major vascular surgery.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Female; Fibrinogen; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Myocardial Ischemia; P-Selectin; Platelet Activation; Vascular Surgical Procedures | 2007 |
[Modified platelet aggregation test in patients on ASA and/or clopidogrel].
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epinephrine; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Thrombosis; Ticlopidine | 2007 |
Hypersensitivity of platelets to adenosine diphosphate in patients with stable cardiovascular disease predicts major adverse events despite antiplatelet therapy.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Cardiovascular Diseases; Collagen; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests | 2008 |
Platelet pro-aggregatory effects of CD40L monoclonal antibody.
Topics: Adenosine Diphosphate; Animals; Antibodies, Monoclonal; Aspirin; Blood Platelets; Calcium; CD40 Antigens; CD40 Ligand; Chelating Agents; Humans; Immunoglobulin Fab Fragments; In Vitro Techniques; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Swine; Thromboxane A2 | 2008 |
Enhanced platelet aggregation and activation under conditions of hypothermia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Anticoagulants; Antigens, CD; Aspirin; Blood Platelets; Blood Specimen Collection; Citrates; Cold Temperature; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Hirudins; Humans; Hypothermia, Induced; In Vitro Techniques; P-Selectin; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Platelet Membrane Glycoproteins; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Receptors, Thrombin; Tetraspanin 30; Time Factors | 2007 |
Standardization of light transmittance aggregometry for monitoring antiplatelet therapy: an adjustment for platelet count is not necessary.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Algorithms; Arachidonic Acid; Aspirin; Calibration; Clopidogrel; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Platelet-Rich Plasma; Sensitivity and Specificity; Thrombophilia; Ticlopidine | 2008 |
Comment on "hyperresponsiveness of platelets in ischemic stroke" by Fateh-Moghadam et al.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Biomarkers; Blood Platelets; Brain Ischemia; Epinephrine; Humans; Ischemic Attack, Transient; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Recurrence; Stroke; Time Factors | 2008 |
How to optimise clopidogrel therapy? Reducing the low-response incidence by aggregometry-guided therapy modification.
Topics: Adenosine Diphosphate; Aged; Algorithms; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Cardiovascular Diseases; Clinical Protocols; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Drug Resistance; Feasibility Studies; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stents; Ticlopidine | 2008 |
Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse.
Topics: Adenosine Diphosphate; Anesthesia; Animals; Aspirin; Blood Platelets; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Erythrocytes; Hemodynamics; Indium Radioisotopes; Injections, Intravenous; Male; Mice; Mice, Inbred BALB C; Organometallic Compounds; Oxyquinoline; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Transfusion; Pulmonary Embolism; Reproducibility of Results; Thrombin; Thromboembolism; Time Factors | 2008 |
Aspirin non-responsiveness in Korean subjects on dual anti-platelet treatment determined by two different platelet function assays.
Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Asian People; Aspirin; Bleeding Time; Case-Control Studies; Clopidogrel; Collagen; Drug Resistance; Epinephrine; Female; Humans; Korea; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2008 |
The ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrine.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Aspirin; Blood Platelets; Calcium; Chromones; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Enzyme Inhibitors; Epinephrine; Hemostatics; Humans; Morpholines; Oligopeptides; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Proto-Oncogene Proteins c-akt; Purinergic Agonists; Purinergic P2 Receptor Agonists; Receptor, PAR-1; Receptors, Adrenergic, alpha-2; Receptors, Purinergic; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Thrombin; Secretory Vesicles; Thrombin | 2008 |
Lack of early augmentation of platelet reactivity after coronary intervention in patients treated with bivalirudin.
Topics: Adenosine Diphosphate; Angina Pectoris; Anticoagulants; Aspirin; Cardiac Catheterization; Clopidogrel; Elective Surgical Procedures; Hemostatics; Hirudins; Humans; Peptide Fragments; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Period; Recombinant Proteins; Thrombin; Ticlopidine; Time Factors | 2009 |
Hydrolysis of adenine nucleotides in platelets from patients with acute myocardial infarction.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aspirin; Blood Platelets; Case-Control Studies; Clopidogrel; Female; Humans; Hydrolysis; Male; Middle Aged; Myocardial Infarction; Ticlopidine | 2008 |
Utility of the PFA-100 instrument and the novel multiplate analyzer for the assessment of aspirin and clopidogrel effects on platelet function in patients with cardiovascular disease.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Clopidogrel; Collagen; Electric Impedance; Epinephrine; Female; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Activation; Platelet Function Tests; Sensitivity and Specificity; Ticlopidine | 2009 |
Dual antiplatelet therapy unmasks distinct platelet reactivity in patients with coronary artery disease.
Topics: Adenosine Diphosphate; Aged; Aspirin; Case-Control Studies; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2008 |
The role of leucocytes in the acetyl salicylic acid (aspirin) induced nitric oxide synthesis in the production of interferon-alpha, a potent inhibitor of platelet aggregation and a thrombolytic agent.
Topics: Adenosine Diphosphate; Adult; Animals; Aspirin; Blood Platelets; Cyclic AMP; Cyclic GMP; Female; Fibrin; Fibrinolysis; Humans; Interferon-alpha; Leukocytes; Male; Mice; Middle Aged; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet-Rich Plasma; Thrombosis | 2009 |
Analysis of platelet alpha2-adrenergic receptor activity in stable coronary artery disease patients on dual antiplatelet therapy.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adrenergic alpha-Antagonists; Aged; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Artery Disease; Drug Resistance; Drug Therapy, Combination; Female; Humans; Imidazoles; Male; Middle Aged; Norepinephrine; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Failure | 2008 |
Association between the efficacy of dual antiplatelet therapy and the development of in-stent neointimal hyperplasia in porcine coronary arteries.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Animals; Aspirin; Cell Proliferation; Clopidogrel; Collagen; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Fibrin; Hyperplasia; Inflammation Mediators; Metals; P-Selectin; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prosthesis Design; Stents; Swine; Ticlopidine; Time Factors; Tunica Intima | 2008 |
[Protective effect of Tongxinluo Ultramicro-pulverization on experimental myocardial infarction of rats].
Topics: Adenosine Diphosphate; Animals; Aspirin; Diltiazem; Drugs, Chinese Herbal; Female; Male; Medicine, Chinese Traditional; Myocardial Infarction; Platelet Aggregation; Random Allocation; Rats; Rats, Sprague-Dawley; Tetrazolium Salts | 2008 |
ADP-induced platelet aggregation in acute ischemic stroke patients on aspirin therapy.
Topics: Acute Disease; Adenosine Diphosphate; Aged; Aspirin; Brain Ischemia; Clopidogrel; Drug Synergism; Drug Therapy, Combination; Endpoint Determination; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2008 |
RhoA downstream of G(q) and G(12/13) pathways regulates protease-activated receptor-mediated dense granule release in platelets.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Blotting, Western; Cytoplasmic Granules; Enzyme Activation; GTP-Binding Proteins; Humans; In Vitro Techniques; Oligopeptides; Peptides, Cyclic; Protein Kinase C-delta; Receptor, PAR-1; Receptors, Thrombin; rhoA GTP-Binding Protein; Thionucleotides; Type C Phospholipases | 2009 |
Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Aspirin; Cohort Studies; Cyclooxygenase 1; Drug Resistance; England; Epinephrine; Female; Gene Frequency; Haplotypes; Humans; Integrin alpha2; Integrin beta3; Male; Membrane Glycoproteins; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins; Polymorphism, Single Nucleotide; Receptors, Purinergic P2; Treatment Failure; Up-Regulation; Vascular Diseases; von Willebrand Factor | 2009 |
Predicting thrombotic events: creating a complex approach for a complex condition.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Reproducibility of Results; Risk Assessment; Risk Factors; ROC Curve; Thrombosis; Ticlopidine | 2008 |
[Recurrent idiopathic cerebral infarction in a 5-year-old boy, with emphasis on the importance of platelet aggregation analysis for appropriate selection of anti-platelet drugs].
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation Tests; Cerebral Infarction; Child, Preschool; Cilostazol; Collagen; Drug Therapy, Combination; Epinephrine; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Tetrazoles; Ticlopidine; Treatment Outcome | 2009 |
Platelet function analysis: at the edge of meaning.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Humans; Microfilament Proteins; Patient Selection; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Reproducibility of Results; Stents; Ticlopidine | 2009 |
Platelets kill intraerythrocytic malarial parasites and mediate survival to infection.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Erythrocytes; Female; Humans; In Situ Nick-End Labeling; Malaria; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Plasmodium chabaudi; Plasmodium falciparum; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Count; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Thrombopoietin | 2009 |
Augmentation of U46619 induced human platelet aggregation by aspirin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Adult; Aspirin; Blood Platelets; Cyclic AMP; Cyclooxygenase Inhibitors; Female; Humans; Male; Nitric Oxide Synthase; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Vasoconstrictor Agents; Young Adult | 2009 |
Evaluation of the platelet count drop method for assessment of platelet function in comparison with "gold standard" light transmission aggregometry.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Reproducibility of Results; Ticlopidine | 2009 |
Clopidogrel and proton pump inhibitors: gastric protection at expense of vascular benefit?
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Humans; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proton Pump Inhibitors; Stents; Ticlopidine | 2009 |
Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Female; Humans; Male; Middle Aged; Multivariate Analysis; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proton Pump Inhibitors; Stents; Ticlopidine | 2009 |
The impact of intravenous aspirin administration on platelet aspirin resistance after on-pump coronary artery bypass surgery.
Topics: Adenosine Diphosphate; Administration, Oral; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Collagen; Coronary Artery Bypass; Drug Resistance; Female; Humans; Injections, Intravenous; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests | 2009 |
Measurement of platelet P-selectin for remote testing of platelet function during treatment with clopidogrel and/or aspirin.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aspirin; Cardiovascular Diseases; Case-Control Studies; Clopidogrel; Drug Monitoring; Female; Flow Cytometry; Humans; Male; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Tissue Fixation | 2009 |
Aprotinin reduces the antiplatelet effect of clopidogrel.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Aprotinin; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Interactions; Drug Therapy, Combination; Female; Hemostatics; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2009 |
Variability in aggregometry response before and after initiation of clopidogrel therapy.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Case-Control Studies; Clopidogrel; Demography; Female; Humans; Male; Middle Aged; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reproducibility of Results; Ticlopidine | 2009 |
Clinical and laboratory factors associated with shear-dependent platelet hyper-reactivity in patients on chronic aspirin therapy.
Topics: Adenosine Diphosphate; Aspirin; Biomarkers; Blood Platelets; Cardiovascular Diseases; Cohort Studies; Collagen; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies | 2010 |
Hydroxyethyl starch interferes with human blood ex vivo coagulation, platelet function and sedimentation.
Topics: Adenosine Diphosphate; Aspirin; Blood Coagulation; Blood Platelets; Blood Sedimentation; Hemodilution; Humans; Hydroxyethyl Starch Derivatives; Platelet Aggregation; Platelet Aggregation Inhibitors | 2009 |
The formation of monocyte-platelet aggregates is independent of on-treatment residual agonists'-inducible platelet reactivity.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Lipopolysaccharide Receptors; Male; Microfilament Proteins; Middle Aged; Monocytes; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Stents; Ticlopidine | 2009 |
Rapamycin enhances platelet aggregation induced by adenosine diphosphate in vitro.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Drug Synergism; Drug-Eluting Stents; Platelet Aggregation; Rabbits; Sirolimus | 2009 |
Effect of blood hematocrit and erythrocyte deformability on adenosine 5'-diphosphate platelet reactivity in patients with acute coronary syndromes on dual antiplatelet therapy.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Blood Viscosity; Clopidogrel; Erythrocyte Deformability; Female; Hematocrit; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Predictive value of post-treatment platelet reactivity for occurrence of post-discharge bleeding after non-ST elevation acute coronary syndrome. Shifting from antiplatelet resistance to bleeding risk assessment?
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Biomarkers; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Intracranial Hemorrhages; Male; Microfilament Proteins; Middle Aged; Patient Discharge; Phosphoproteins; Phosphorylation; Pilot Projects; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Risk Assessment; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
The influence of clinical characteristics, laboratory and inflammatory markers on 'high on-treatment platelet reactivity' as measured with different platelet function tests.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Blood Platelets; Cells, Cultured; Clopidogrel; Drug Combinations; Female; Humans; Interleukin-6; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Sensitivity and Specificity; Thrombosis; Ticlopidine | 2009 |
Effects of clopidogrel on "aspirin specific" pathways of platelet inhibition.
Topics: Adenosine Diphosphate; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Drug Interactions; Female; Humans; Male; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Impact of genetic polymorphisms on platelet function and aspirin resistance.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Proteins; Collagen; Drug Resistance; Epinephrine; Female; Genetic Association Studies; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Thrombophilia | 2010 |
Platelet function recovery after cessation of aspirin: preliminary study of volunteers and surgical patients.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Coagulation; Blood Platelets; Case-Control Studies; Drug Administration Schedule; Elective Surgical Procedures; Epinephrine; Female; Humans; International Normalized Ratio; Longitudinal Studies; Male; Middle Aged; Partial Thromboplastin Time; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Recovery of Function; Thromboxane B2; Time Factors; Young Adult | 2010 |
Acetylsalicylic acid enhances purinergic receptor-mediated outward currents in rat megakaryocytes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aspirin; Calcium; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Fibrinolytic Agents; Ionophores; Kinetics; Male; Megakaryocytes; Membrane Potentials; Nystatin; Patch-Clamp Techniques; Platelet Aggregation Inhibitors; Potassium; Potassium Channels, Calcium-Activated; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Purinergic; Receptors, Thromboxane; Signal Transduction; Thionucleotides | 2010 |
Anxiety is a better predictor of platelet reactivity in coronary artery disease patients than depression.
Topics: Adenosine Diphosphate; Aged; Angina, Unstable; Anxiety Disorders; Aspirin; Clopidogrel; Cross-Sectional Studies; Depressive Disorder; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Serotonin; Ticlopidine | 2010 |
Mechanism of platelet functional changes and effects of anti-platelet agents on in vivo hemostasis under different gravity conditions.
Topics: Actin Cytoskeleton; Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Calcium; Chelating Agents; Contractile Proteins; Egtazic Acid; Filamins; Hemostasis; Humans; Hypergravity; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microfilament Proteins; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Protein Binding; Ristocetin; Thrombosis; Time Factors; Tirofiban; Tyrosine; Weightlessness Simulation | 2010 |
Adrenergic receptor polymorphisms and platelet reactivity after treatment with dual antiplatelet therapy with aspirin and clopidogrel in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Aspirin; Cell Adhesion Molecules; Chi-Square Distribution; Clopidogrel; Drug Therapy, Combination; Female; Gene Frequency; Genotype; Humans; Linear Models; Male; Microfilament Proteins; Middle Aged; Phenotype; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Prospective Studies; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta-2; Ticlopidine; Treatment Outcome | 2010 |
Oral anticoagulation with coumarin derivatives and antiplatelet effects of clopidogrel.
Topics: Adenosine Diphosphate; Administration, Oral; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Disease; Cross-Sectional Studies; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Multivariate Analysis; Phenprocoumon; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Evaluation of antiplatelet effects of a modified protocol by platelet aggregation in patients undergoing "one-stop" hybrid coronary revascularization.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Artery Bypass; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; Ticlopidine | 2010 |
Changes in platelets and anticoagulant protein activity during adenosine-exercise single-photon emission computed tomography stress test.
Topics: Adenosine; Adenosine Diphosphate; Adult; Aged; Antithrombins; Aspirin; beta-Thromboglobulin; Blood Coagulation; Clopidogrel; Coronary Stenosis; Epinephrine; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Perfusion Imaging; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Factor 4; Protein C; Ticlopidine; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 2010 |
Platelet activation patterns in platelet size sub-populations: differential responses to aspirin in vitro.
Topics: Acid Phosphatase; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Cell Size; Cells, Cultured; Fibrinogen; Humans; Isoenzymes; P-Selectin; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Tartrate-Resistant Acid Phosphatase; Thromboxane B2; von Willebrand Factor | 2010 |
Evaluation of platelet function and pharmacological platelet inhibition in patients with myeloproliferative disorders using multiple electrode aggregometry.
Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Austria; Case-Control Studies; Clopidogrel; Electrodes; Female; Humans; Linear Models; Male; Middle Aged; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polycythemia Vera; Predictive Value of Tests; Reproducibility of Results; Thrombocythemia, Essential; Thrombosis; Ticlopidine; Treatment Outcome; Young Adult | 2010 |
Association between inflammatory biomarkers and platelet aggregation in patients under chronic clopidogrel treatment.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; C-Reactive Protein; Cardiovascular Diseases; Chi-Square Distribution; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Female; Fibrinogen; Germany; Humans; Inflammation Mediators; Leukocyte Count; Linear Models; Logistic Models; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Retrospective Studies; Risk Assessment; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Biomarkers; Blood Platelets; Case-Control Studies; Chi-Square Distribution; Collagen; Coronary Artery Disease; Denmark; Diabetes Mellitus, Type 2; Female; Humans; Linear Models; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Registries; Risk Assessment; Risk Factors; Smoking; Thrombopoietin; Thromboxane B2 | 2011 |
Clopidogrel discontinuation and platelet reactivity following coronary stenting.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Epinephrine; Female; Humans; Ireland; Male; Middle Aged; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Influence of treatment with ultralow-dose aspirin on platelet aggregation as measured by whole blood impedance aggregometry and platelet P-selectin expression in clinically normal dogs.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Body Composition; Body Weight; Dogs; Dose-Response Relationship, Drug; Female; Flow Cytometry; Gene Expression Regulation; Male; Orchiectomy; Ovariectomy; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values | 2010 |
Prostaglandin E2 differentially modulates human platelet function through the prostanoid EP2 and EP3 receptors.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Calcium; Cell Adhesion Molecules; Collagen; Dinoprostone; Dose-Response Relationship, Drug; Humans; Microfilament Proteins; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Aggregation; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype | 2011 |
Nontraumatic bilateral subdural hematoma caused by antiaggregation therapy: case report and review of the literature.
Topics: Adenosine Diphosphate; Aspirin; Clopidogrel; Female; Hematoma, Subdural; Humans; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Radiography; Ticlopidine | 2010 |
Inconsistency of different methods for assessing ex vivo platelet function: relevance for the detection of aspirin resistance.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboxane B2; Young Adult | 2010 |
In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Aspirin; Collagen; Drug Synergism; Epinephrine; Humans; In Vitro Techniques; Peptide Fragments; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thromboxane A2 | 2011 |
Influence of nonsteroidal anti-inflammatory drugs on the antiplatelet effects of aspirin in rats.
Topics: Acetylation; Adenosine Diphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Collagen; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Drug Interactions; Etodolac; Ibuprofen; Male; Phenylpropionates; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 2011 |
Evaluation of desmopressin effect on primary haemostasis in pediatric patients with aspirin-like defect as hereditary thrombocytopathy.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Aspirin; Blood Platelet Disorders; Blood Platelets; Child; Child, Preschool; Deamino Arginine Vasopressin; Female; Hemostasis; Hemostatics; Humans; Infusions, Intravenous; Male; Platelet Aggregation; Platelet Function Tests; Thrombin; von Willebrand Factor | 2011 |
Short-term exposure of platelets to glucose impairs inhibition of platelet aggregation by cyclooxygenase inhibitors.
Topics: Acetaminophen; Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cells, Cultured; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Glucose; Humans; Indomethacin; Lactic Acid; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet-Rich Plasma | 2011 |
The influencing factors for clopidogrel-mediated platelet inhibition are assay-dependent.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Austria; Biomarkers; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Drug Therapy, Combination; Female; Humans; Linear Models; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Receptors, Purinergic P2Y12; Reproducibility of Results; Risk Assessment; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2011 |
Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis.
Topics: Adenosine Diphosphate; Angiogenesis Modulating Agents; Aspirin; Blood Platelets; Breast Neoplasms; Carcinoma; Cells, Cultured; Endostatins; Endothelial Cells; Female; Humans; Models, Biological; Neovascularization, Pathologic; Neovascularization, Physiologic; Secretory Vesicles; Thromboxane A2; Vascular Endothelial Growth Factor A | 2011 |
Platelet reactivity is a stable and global phenomenon in aspirin-treated cardiovascular patients.
Topics: Adenosine Diphosphate; Aged; Aspirin; Cardiovascular Diseases; Epinephrine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Activation; Platelet Function Tests; Practice Guidelines as Topic; Proteomics; Severity of Illness Index | 2011 |
Relation of body mass index to on-treatment (clopidogrel + aspirin) platelet reactivity.
Topics: Adenosine Diphosphate; Aspirin; Body Mass Index; Cell Adhesion Molecules; Clopidogrel; Coronary Disease; Female; Humans; Logistic Models; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Function Tests; Risk Factors; Statistics, Nonparametric; Ticlopidine | 2011 |
Reduction of thienopyridine-associated bleeding using multiple electrode whole-blood aggregometry.
Topics: Adenosine Diphosphate; Aspirin; Cardiopulmonary Bypass; Electrodes; Heart Diseases; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Hemorrhage; Predictive Value of Tests; Preoperative Care; Thienopyridines; Thrombelastography; Whole Blood Coagulation Time | 2011 |
[Effect of acetylsalicylic acid in complex with lipid nanostructures of various compositions on human platelet aggregation].
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Brain Chemistry; Cerebrovascular Disorders; Chromatography, Thin Layer; Drug Carriers; Glycosphingolipids; Humans; Lipid Bilayers; Liposomes; Nanostructures; Platelet Aggregation; Platelet Aggregation Inhibitors; Static Electricity; Swine | 2011 |
Characterization of a unique dihydropyrimidinone, ethyl 4-(4'-heptanoyloxyphenyl)-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylate, as an effective antithrombotic agent in a rat experimental model.
Topics: Adenosine Diphosphate; Animals; Aorta; Aspirin; Blood Platelets; Collagen; Cyclic GMP; Drug Synergism; Inflammation Mediators; Inhibitory Concentration 50; Lipopolysaccharides; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Platelet Aggregation Inhibitors; Pyrimidinones; Rats; Rats, Sprague-Dawley; Thrombin; Thromboplastin; Thrombosis | 2011 |
Direct evidence for normalization of platelet function resulting from platelet count reduction in essential thrombocythemia.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Collagen; Epinephrine; Female; Greece; Humans; Hydroxyurea; Interferon-alpha; Janus Kinase 2; Longitudinal Studies; Male; Middle Aged; Platelet Aggregation; Platelet Count; Platelet Function Tests; Point Mutation; Regression Analysis; Thrombocythemia, Essential; von Willebrand Factor | 2011 |
Time dependence of clopidogrel loading effect: platelet activation versus platelet aggregation.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Annexin A5; Aspirin; Baltimore; Clopidogrel; Collagen; Coronary Artery Disease; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Comparison of venous and arterial blood sampling for the assessment of platelet aggregation with whole blood impedance aggregometry.
Topics: Adenosine Diphosphate; Arachidonic Acid; Area Under Curve; Arteries; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Electric Impedance; Female; Humans; Male; Phlebotomy; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Research Design; Specimen Handling; Ticlopidine; Veins | 2011 |
Comparison of platelet reactivity and clopidogrel response in patients ≤ 75 Years Versus > 75 years undergoing percutaneous coronary intervention for non-ST-segment elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Age Factors; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Resistance; Follow-Up Studies; Hemorrhage; Humans; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Stents; Ticlopidine | 2011 |
High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PCI.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Angioplasty; Aspirin; Clopidogrel; Death; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Risk; Stents; Stroke; Thrombosis; Ticlopidine | 2011 |
Effects of P2Y(1) receptor antagonism on the reactivity of platelets from patients with stable coronary artery disease using aspirin and clopidogrel.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y1; Receptors, Thrombin; Thrombosis; Ticlopidine | 2012 |
Platelet reactivity in type 2 diabetes mellitus: a comparative analysis with survivors of myocardial infarction and the role of glycaemic control.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Blood Glucose; Blood Platelets; Collagen; Diabetes Mellitus, Type 2; Epinephrine; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Severity of Illness Index; Survivors | 2012 |
The relevance of P2Y(12)-receptor gene variation for the outcome of clopidogrel-treated patients undergoing elective coronary stent implantation: a clinical follow-up.
Topics: Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Female; Follow-Up Studies; Genetic Variation; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Polymorphism, Single Nucleotide; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Software; Stents; Ticlopidine | 2012 |
Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin.
Topics: Adenosine Diphosphate; Aged; Alprostadil; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Diabetes Mellitus; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Ticlopidine | 2013 |
Effect of different anticoagulants on multiple electrode platelet aggregometry after clopidogrel and aspirin administration in patients undergoing coronary stent implantation: a comparison between citrate and hirudin.
Topics: Adenosine Diphosphate; Aged; Analysis of Variance; Angioplasty, Balloon, Coronary; Anticoagulants; Arachidonic Acid; Aspirin; Citric Acid; Clopidogrel; Female; Hirudins; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; ROC Curve; Sensitivity and Specificity; Stents; Ticlopidine | 2013 |
Simultaneous assay of activated platelet count and platelet-activating capacity by P-selectin detection using K2-EDTA-treated whole blood for antiplatelet agents.
Topics: Adenosine Diphosphate; Anticoagulants; Aspirin; Blood Platelets; Citrates; Collagen; Drug Monitoring; Edetic Acid; Female; Flow Cytometry; Heparin; Humans; Male; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Count; Reproducibility of Results; Sodium Citrate; Thrombosis; Time Factors; Young Adult | 2012 |
In vitro platelet antiaggregatory properties of 4-methylcoumarins.
Topics: Adenosine Diphosphate; Anticoagulants; Arachidonic Acid; Aspirin; Collagen; Coumarins; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Humans; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane-A Synthase; Umbelliferones | 2012 |
Clinical and biochemical aspirin resistance in patients with recurrent cerebral ischemia.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Brain Ischemia; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Specimen Handling; Treatment Failure | 2013 |
Postmenopausal women have an increased maximal platelet reactivity compared to men despite dual antiplatelet therapy.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Coronary Disease; Female; Humans; Male; Middle Aged; Peptide Fragments; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Postmenopause; Prospective Studies; Sex Factors; Ticlopidine | 2012 |
Evaluation of the pharmacokinetics and pharmacodynamics of ticagrelor co-administered with aspirin in healthy volunteers.
Topics: Adenosine; Adenosine Diphosphate; Adult; Aspirin; Bleeding Time; Clopidogrel; Collagen; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine; Young Adult | 2013 |
Assessment of high on-treatment platelet reactivity in patients with ischemic heart disease: concordance between the Multiplate and VerifyNow assays.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Reproducibility of Results; Spain; Ticlopidine; Treatment Outcome | 2013 |
Human platelet protease-activated receptor-1 responsiveness to thrombin related to P2Y12 inhibition.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Models, Cardiovascular; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptor, PAR-1; Receptors, Purinergic P2Y12; Thrombin; Thromboembolism; Ticlopidine; Translational Research, Biomedical | 2013 |
Preserved thrombin-inducible platelet activation in thienopyridine-treated patients.
Topics: Adenosine Diphosphate; Aged; Angioplasty; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Female; Humans; Integrin beta3; Male; Middle Aged; P-Selectin; Peptide Fragments; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoprotein IIb; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Thiophenes; Thrombin; Ticlopidine | 2013 |
ADP-induced platelet aggregation and thrombin generation are increased in Essential Thrombocythemia and Polycythemia Vera.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Female; Humans; Janus Kinase 2; Male; Middle Aged; Mutation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polycythemia Vera; Thrombin; Thrombocythemia, Essential; Young Adult | 2013 |
Contact- and agonist-regulated microvesiculation of human platelets.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Cell Shape; Cell-Derived Microparticles; Clopidogrel; Fibrinogen; Humans; Microscopy, Atomic Force; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Hidden implications: potential antiplatelet effects of adjuvant anaesthetic agents.
Topics: Adenosine Diphosphate; Adjuvants, Anesthesia; Aged; Aspirin; Cholecystectomy, Laparoscopic; Clopidogrel; Female; Hemorrhage; Humans; Intraoperative Complications; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombelastography; Ticlopidine | 2013 |
Initial experiences with Multiplate® for rapid assessment of antiplatelet agent activity in neurosurgical emergencies.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Clopidogrel; Embolization, Therapeutic; Emergencies; Emergency Medical Services; Female; Hemostatic Techniques; Humans; Intracranial Hemorrhages; Male; Middle Aged; Neurosurgical Procedures; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Transfusion; Point-of-Care Systems; Ticlopidine | 2013 |
High-dose, but not low-dose, aspirin impairs anticontractile effect of ticagrelor following ADP stimulation in rat tail artery smooth muscle cells.
Topics: Adenosine; Adenosine Diphosphate; Animals; Arteries; Aspirin; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Muscle Contraction; Myocytes, Smooth Muscle; Rats; Tail; Ticagrelor; Vasoconstriction | 2013 |
Impact of aspirin dose on adenosine diphosphate-mediated platelet activities. Results of an in vitro pilot investigation.
Topics: Adenosine Diphosphate; Aged; Aspirin; Cell Adhesion Molecules; Coronary Artery Disease; Drug Dosage Calculations; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Pilot Projects; Piperazines; Platelet Activation; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Thiophenes | 2013 |
Antiplatelet loading improves behavioral outcome in a rabbit model of stroke.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Brain Ischemia; Collagen; Disease Models, Animal; Embolization, Therapeutic; Fibrinolytic Agents; Male; Platelet Aggregation Inhibitors; Rabbits; Random Allocation; Treatment Outcome | 2013 |
Effects of ex vivo platelet supplementation on platelet aggregability in blood samples from patients treated with acetylsalicylic acid, clopidogrel, or ticagrelor.
Topics: Adenosine; Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Transfusion; Ticagrelor; Ticlopidine | 2014 |
Changes in response to antiaggregatory treatment in patients with myeloproliferative neoplasms: a sequential study using multiple electrode aggregometry.
Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Case-Control Studies; Clopidogrel; Electrodes; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Myeloproliferative Disorders; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Thrombosis; Ticlopidine; Treatment Outcome | 2013 |
The evaluation method for antiplatelet effect of acetylsalicylic acid.
Topics: Adenosine Diphosphate; Adult; Aspirin; Collagen; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors | 2014 |
Detection of platelet sensitivity to inhibitors of COX-1, P2Y₁, and P2Y₁₂ using a whole blood microfluidic flow assay.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Humans; Microfluidic Analytical Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists | 2014 |
Response to antiplatelet therapy and platelet reactivity to thrombin receptor activating peptide-6 in cardiovascular interventions: Differences between peripheral and coronary angioplasty.
Topics: Adenosine Diphosphate; Aged; Angioplasty; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Monocytes; P-Selectin; Peptide Fragments; Percutaneous Coronary Intervention; Peripheral Arterial Disease; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prognosis; Stents; Ticlopidine | 2014 |
The role of clinical parameters and of CYP2C19 G681 and CYP4F2 G1347A polymorphisms on platelet reactivity during dual antiplatelet therapy.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Thrombosis; Ticlopidine | 2014 |
Adenosine diphosphate-induced single-platelet count aggregation and bleeding in clopidogrel-treated patients undergoing coronary artery bypass grafting.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Anesthesia; Aspirin; Blood Transfusion; Chest Tubes; Clopidogrel; Confidence Intervals; Coronary Artery Bypass; Critical Care; Erythrocyte Count; Female; Humans; Linear Models; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Postoperative Hemorrhage; Prospective Studies; Risk Factors; Ticlopidine | 2014 |
Association between the microarray-based CYP2C19 genotyping assay and the platelet function test in cardiovascular patients receiving clopidogrel.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Alleles; Asian People; Aspirin; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Gene Expression; Genotype; Humans; Isoenzymes; Microarray Analysis; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2Y12; Ticlopidine | 2014 |
Point-of-care testing of clopidogrel-mediated platelet inhibition and risk for cardiovascular events after coronary angiography with or without percutaneous coronary intervention.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Angiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Patient Readmission; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Point-of-Care Systems; Predictive Value of Tests; Prospective Studies; ROC Curve; Stents; Survival Analysis; Thrombosis; Ticlopidine | 2014 |
Characterization of UBO-QIC as a Gαq inhibitor in platelets.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Calcium; Depsipeptides; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Mice; Mice, Knockout; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Signal Transduction | 2015 |
Effects of Paclitaxel on the Ability of Aspirin and Clopidogrel to Inhibit Platelet Aggregation.
Topics: Adenosine Diphosphate; Adult; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Male; Paclitaxel; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Young Adult | 2016 |
Calcium-Channel Blockers Attenuate the Antiplatelet Effect of Clopidogrel.
Topics: Adenosine Diphosphate; Aged; Angioplasty; Aspirin; Calcium Channel Blockers; Clopidogrel; Dihydropyridines; Drug Interactions; Female; Flow Cytometry; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine | 2015 |
Comparison of aspirin and indobufen in healthy volunteers.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Cross-Over Studies; Drug Administration Schedule; Female; Healthy Volunteers; Humans; Isoindoles; Male; Middle Aged; Phenylbutyrates; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandin-Endoperoxide Synthases; Thromboxane B2 | 2016 |
Preventive Effect of Aspirin Eugenol Ester on Thrombosis in κ-Carrageenan-Induced Rat Tail Thrombosis Model.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Carrageenan; Disease Models, Animal; Erythrocyte Count; Erythrocytes; Eugenol; Fibrinogen; Hemoglobins; Male; Platelet Aggregation Inhibitors; Platelet Count; Prothrombin Time; Rats; Rats, Wistar; Thrombosis | 2015 |
The effectiveness of platelet supplementation for the reversal of ticagrelor-induced inhibition of platelet aggregation: An in-vitro study.
Topics: Adenosine; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Transfusion; Ticagrelor | 2016 |
Low platelet activity predicts 30 days mortality in patients undergoing heart surgery.
Topics: Adenosine Diphosphate; Aged; Aortic Valve; Arachidonic Acid; Area Under Curve; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Erythrocyte Transfusion; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Retrospective Studies; Risk Factors; Survival Analysis; Thrombosis; Ticlopidine; Treatment Outcome | 2016 |
Acetylsalicylic acid resistance risk factors in patients with myocardial infarction.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; C-Reactive Protein; Drug Resistance; Female; Humans; Leukocyte Count; Male; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Platelet Aggregation; Platelet Aggregation Inhibitors; Prevalence; Prospective Studies; Risk Factors | 2015 |
[Interaction of the Humoral Agonist During the Platelets Activation in Patients with Chronic Cerebral Ischemia].
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Brain; Brain Ischemia; Chronic Disease; Epinephrine; Female; Humans; Intracranial Thrombosis; Male; Microcirculation; Platelet Activating Factor; Platelet Activation; Platelet Aggregation Inhibitors; Serotonin | 2015 |
Advanced age and high-residual platelet reactivity in patients receiving dual antiplatelet therapy with clopidogrel or ticagrelor.
Topics: Adenosine; Adenosine Diphosphate; Age Factors; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Female; Humans; Male; Middle Aged; Odds Ratio; Patient Discharge; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prevalence; Thrombosis; Ticagrelor; Ticlopidine; Time Factors | 2016 |
Relationship between high on aspirin platelet reactivity and oxidative stress in coronary artery by-pass grafted patients.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Collagen; Coronary Artery Bypass; Coronary Artery Disease; Coronary Vessels; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Oxidative Stress; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 2016 |
Platelet aggregation in response to ADP is highly variable in normal donors and patients on anti-platelet medication.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Case-Control Studies; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests | 2016 |
Design, Synthesis and Pharmacological Evaluation of Novel Piperlongumine derivatives as Potential Antiplatelet Aggregation Candidate.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Blood Platelets; Dioxolanes; Drug Evaluation, Preclinical; Humans; Piperidones; Platelet Aggregation; Platelet Aggregation Inhibitors | 2016 |
Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adult; Animals; Aspirin; Blood Coagulation; Blood Platelets; Coronary Thrombosis; Dinucleoside Phosphates; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Fibrinolytic Agents; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Rats, Sprague-Dawley; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Time Factors; Young Adult | 2016 |
The Antiplatelet Effect of Clopidogrel Decreases With Patient Age.
Topics: Adenosine Diphosphate; Age Factors; Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Flow Cytometry; Humans; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Treatment Outcome | 2016 |
Parathyroid Hormone Levels and High-Residual Platelet Reactivity in Patients Receiving Dual Antiplatelet Therapy With Acetylsalicylic Acid and Clopidogrel or Ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Diphosphate; Aged; Aspirin; Biomarkers; Clopidogrel; Coronary Artery Disease; Databases, Factual; Drug Resistance; Drug Therapy, Combination; Female; Homeodomain Proteins; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Ticagrelor; Ticlopidine; Time Factors; Transcription Factors; Treatment Outcome; Up-Regulation | 2016 |
Head to Head Comparison of Two Point-of-care Platelet Function Tests Used for Assessment of On-clopidogrel Platelet Reactivity in Chinese Acute Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; China; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Receptors, Purinergic P2Y12; Thrombelastography; Ticlopidine | 2016 |
Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin-Dependent Effects on Platelet Aggregation Pathways.
Topics: Adenosine Diphosphate; Adult; Alleles; Amish; Aspirin; Biomarkers; Blood Platelets; Collagen; Epinephrine; Female; Genotype; Healthy Volunteers; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prospective Studies; Receptors, Cell Surface; Thromboxane B2 | 2017 |
Platelet dysfunction in critically ill patients.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelet Disorders; Critical Illness; Female; Humans; Male; Middle Aged; Platelet Function Tests; Retrospective Studies; Thrombelastography | 2017 |
Platelet reactivity in thromboelastometry. Revision of the FIBTEM test: a basic study.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Coagulation Tests; Blood Platelets; Collagen; Cytochalasin D; Female; Fibrin; Fibrinogen; Humans; Integrin beta3; Male; Oligopeptides; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoprotein IIb; Primary Cell Culture; Thrombelastography | 2017 |
Modulation of vascular function and anti-aggregation effect induced by (1→3) (1→6)-β-d-glucan of Saccharomyces cerevisiae and its carboxymethylated derivative in rats.
Topics: Adenosine Diphosphate; Animals; Aspirin; beta-Glucans; Blood Platelets; Collagen; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Saccharomyces cerevisiae | 2017 |
Hemostatic effects of the ticagrelor antidote MEDI2452 in pigs treated with ticagrelor on a background of aspirin.
Topics: Adenosine; Adenosine Diphosphate; Animals; Antibodies, Neutralizing; Antidotes; Aspirin; Biotinylation; Blood Pressure; Broadly Neutralizing Antibodies; Hemorrhage; Hemostasis; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Swine; Ticagrelor; Time Factors | 2017 |
Synthesis, antiplatelet and antithrombotic activities of resveratrol derivatives with NO-donor properties.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Bleeding Time; Collagen; Fibrinolytic Agents; Hydrazones; Isosorbide Dinitrate; Male; Mice; Nitric Oxide Donors; Nitrites; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats, Wistar | 2017 |
High On-Treatment Platelet Reactivity to Adenosine Diphosphate Predicts Ischemic Events of Minor Stroke and Transient Ischemic Attack.
Topics: Adenosine Diphosphate; Adult; Aged; Aspirin; Blood Platelets; Brain Ischemia; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Ischemic Attack, Transient; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Recurrence; Risk Factors; Stroke; Thrombelastography; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Decreased platelet inhibition by P2Y12 receptor blockers in anaemia.
Topics: Adenosine; Adenosine Diphosphate; Aged; Anemia; Angioplasty; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Monocytes; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Ticagrelor; Ticlopidine | 2018 |
Impact of Proton-pump Inhibitors on the Pharmacodynamic Effect and Clinical Outcomes in Patients Receiving Dual Antiplatelet Therapy after Percutaneous Coronary Intervention: A Propensity Score Analysis.
Topics: Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Thrombelastography; Ticlopidine | 2017 |
On-treatment platelet reactivity in peripheral and coronary blood in patients undergoing primary PCI for ST-segment elevation myocardial infarction (STEMI).
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Coronary Vessels; Demography; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; ST Elevation Myocardial Infarction | 2018 |
Effect of Physical Exercise on Platelet Reactivity in Patients with Dual Antiplatelet Therapy.
Topics: Adenosine Diphosphate; Aspirin; Chromogranin A; Clopidogrel; Coronary Artery Disease; Electrocardiography; Exercise; Exercise Tolerance; Humans; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Count; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Thrombosis; Ticlopidine | 2018 |
Comparison of factors affecting platelet reactivity in various platelet function tests.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Ticlopidine | 2019 |
[ADP-Induced Recalcified Blood Clotting Time as a Marker of Rethrombosis Risk and Effectiveness of Antiplatelet Therapy in Acute Coronary Syndrome].
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Adult; Aspirin; Biomarkers; Humans; Male; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Thrombosis; Whole Blood Coagulation Time | 2018 |
Aspirin-Dependent Effects on Purinergic P2Y1 Receptor Expression.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cell Line; Female; Gene Expression Regulation; Humans; Male; Megakaryocyte Progenitor Cells; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; PPAR alpha; Pyrimidines; Receptors, Purinergic P2Y1 | 2019 |
Canine platelets express functional Toll-like receptor-4: lipopolysaccharide-triggered platelet activation is dependent on adenosine diphosphate and thromboxane A2 in dogs.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Dogs; Lipopolysaccharides; Platelet Activation; Rhodobacter sphaeroides; Thromboxane A2; Toll-Like Receptor 4 | 2019 |
Residual platelet reactivity is preferred over platelet inhibition rate in monitoring antiplatelet efficacy: insights using thrombelastography.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Thrombelastography | 2020 |
Estimating short- and long-term reference change values and index of individuality for tests of platelet function.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Biological Variation, Population; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Normal Distribution; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reference Values; Thrombosis | 2019 |
Ticagrelor and prasugrel are independent predictors of improved long-term survival in ACS patients.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Cardiovascular Diseases; Clopidogrel; Dual Anti-Platelet Therapy; Female; Humans; Male; Middle Aged; Mortality; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prognosis; Proportional Hazards Models; Prospective Studies; Secondary Prevention; Stroke; Survival Rate; Ticagrelor | 2020 |
Lower Platelet Aggregation Is a Risk Factor for Dual Antiplatelet Therapy-Associated Bleeding: A Preliminary Retrospective Study with Genotype Analysis.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Case-Control Studies; Dual Anti-Platelet Therapy; Female; Genotype; Glutathione S-Transferase pi; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Polymorphism, Single Nucleotide; Receptors, Cell Surface; Retrospective Studies; Ticagrelor | 2020 |
Synergistic platelet inhibition between Omega-3 and acetylsalicylic acid dose titration; an observational study.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Drug Synergism; Drug Therapy, Combination; Fatty Acids, Omega-3; Humans; Male; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Young Adult | 2020 |
Comparison of acetylsalicylic acid and clopidogrel non-responsiveness assessed by light transmittance aggregometry and PFA-100® in patients undergoing neuroendovascular procedures.
Topics: Adenosine Diphosphate; Aged; Alprostadil; Aspirin; Blood Coagulation Tests; Blood Platelets; Clopidogrel; Collagen; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Reproducibility of Results; Stents; Technology Assessment, Biomedical; Thrombosis; Time Factors | 2020 |
Cilostazol increases adenosine plasma concentration in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Diphosphate; Aged; Aspirin; China; Cilostazol; Clopidogrel; Cyclic AMP; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Function Tests | 2021 |
Elevated Serum Levels of Alkaline Phosphatase and the Risk of Low Responsiveness to Clopidogrel.
Topics: Adenosine Diphosphate; Aged; Alkaline Phosphatase; Aspirin; Clopidogrel; Dual Anti-Platelet Therapy; Female; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Thrombelastography; Treatment Outcome | 2020 |
Serotonin-Affecting Antidepressant Use in Relation to Platelet Reactivity.
Topics: Adenosine Diphosphate; Antidepressive Agents; Aspirin; Blood Platelets; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Serotonin | 2022 |
Being Overweight or Obese Is Associated with an Increased Platelet Reactivity Despite Dual Antiplatelet Therapy with Aspirin and Clopidogrel.
Topics: Adenosine; Adenosine Diphosphate; Aspirin; Blood Platelets; Clopidogrel; Humans; Obesity; Overweight; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticagrelor; Ticlopidine | 2023 |
Does thromboelastography predict bleeding in patients treated with clopidogrel or ticagrelor in off-pump coronary artery bypass grafting?
Topics: Adenosine Diphosphate; Adult; Aspirin; Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Thrombelastography; Ticagrelor | 2022 |
Polysaccharide-protein complex from coelomic fluid of Dendrobaena veneta earthworm exerts a multi-pathway antiplatelet effect without coagulopathy and cytotoxicity.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Humans; Oligochaeta; Platelet Aggregation; Platelet Aggregation Inhibitors; Polysaccharides | 2022 |
Low platelet reactivity in patients with myocardial infarction treated with aspirin plus ticagrelor.
Topics: Adenosine Diphosphate; Aspirin; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticagrelor; Treatment Outcome | 2022 |
The Association between Glycosylated Hemoglobin Level and Platelets Reactivity in Patients with Diabetes Mellitus Undergoing Elective Coronary Artery Bypass Grafting.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Coronary Artery Bypass; Diabetes Mellitus; Glycated Hemoglobin; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Treatment Outcome | 2023 |
Impact of the
Topics: Adenosine Diphosphate; Aspirin; Cardiovascular Diseases; China; Clopidogrel; Humans; Hyperglycemia; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Cell Surface | 2022 |
Aspirin Administration Mitigates Platelet Hyperaggregability After Splenectomy in a Murine Model.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Disease Models, Animal; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Splenectomy | 2022 |
Effectiveness of aspirin vs. clopidogrel in dogs with immune mediated haemolytic anaemia evaluated by serial thromboelastography and platelet mapping.
Topics: Adenosine Diphosphate; Anemia, Hemolytic, Autoimmune; Animals; Aspirin; Blood Platelets; Clopidogrel; Dog Diseases; Dogs; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Thrombelastography; Thromboxanes | 2022 |
Assessment of on-treatment platelet reactivity at high and low shear stress and platelet activation status after the addition of dipyridamole to aspirin in the early and late phases after TIA and ischaemic stroke.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Brain Ischemia; Dipyridamole; Humans; Ischemic Attack, Transient; Ischemic Stroke; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Stroke | 2022 |
Postoperative myocardial injury and platelet reactivity in patients undergoing vascular surgery: The platelet reactivity and postoperative myocardial injury after major vascular surgery (PROMISE) study.
Topics: Adenosine Diphosphate; Aspirin; Cohort Studies; Diterpenes; Heart Injuries; Humans; Myocardium; P-Selectin; Platelet Activation; Postoperative Period; Prospective Studies; Troponin; Vascular Surgical Procedures | 2022 |
Serial assessment of thrombogenicity and hemodynamics in patients with type II diabetes in a clinical research unit: Evidence for circadian variations in clot formation.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Pressure; Circadian Rhythm; Diabetes Mellitus, Type 2; Humans; Thrombosis | 2022 |
Platelet function testing using the Multiplate analyzer after administration of aspirin in Aachen minipigs.
Topics: Adenosine; Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Diphosphates; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Thrombin; Swine; Swine, Miniature | 2022 |
High-Intensity Exercise Training Improves Basal Platelet Prostacyclin Sensitivity and Potentiates the Response to Dual Anti-Platelet Therapy in Postmenopausal Women.
Topics: Adenosine; Adenosine Diphosphate; Aspirin; Cyclooxygenase 1; Diphosphates; Dual Anti-Platelet Therapy; Epoprostenol; Estrogens; Exercise; Female; Humans; Nitric Oxide; Peptides; Platelet Aggregation Inhibitors; Postmenopause; Receptors, Epoprostenol; Receptors, Thromboxane; Thrombin; Thrombosis; Thromboxanes | 2022 |
Thromboelastography 6s for assessment of platelet function during coil embolization of unruptured intracranial aneurysms.
Topics: Adenosine Diphosphate; Aspirin; Embolization, Therapeutic; Humans; Intracranial Aneurysm; Platelet Aggregation Inhibitors; Retrospective Studies; Thrombelastography; Treatment Outcome | 2023 |