aspirin has been researched along with 2,5-dihydroxybenzoic acid in 46 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (30.43) | 18.7374 |
| 1990's | 13 (28.26) | 18.2507 |
| 2000's | 8 (17.39) | 29.6817 |
| 2010's | 8 (17.39) | 24.3611 |
| 2020's | 3 (6.52) | 2.80 |
| Authors | Studies |
|---|---|
| Ban, HS; Ishihara, K; Nabeyama, W; Nakamura, H; Wada, H | 1 |
| Cavallo, G; Chessa, MA; Milazzotto, F; Natale, E; Pensa, V; Ricci, R; Tubaro, E; Tubaro, M | 1 |
| De Mattia, G; Ferro-Luzzi, A; Ghiselli, A; Laurenti, O; Maiani, G | 1 |
| Klimes, J; Sedlácek, J; Sochor, J; Zahradnícek, M | 1 |
| de Gaetano, G; Lorico, A; Masturzo, P; Salmona, M; Semeraro, N; Villa, S | 1 |
| Amezcua, JL; Favari, L; Mourelle, M | 1 |
| Grootveld, M; Halliwell, B | 1 |
| Gryglewski, RJ; Marcinkiewicz, E; Michalska, Z; Radomski, M | 1 |
| Hiraga, K; Takahashi, O | 1 |
| Chalmers, IM; Hunter, T; Sitar, DS | 1 |
| Badcock, NR; Everett, DS; Penna, AC; Sansom, LN | 1 |
| Beach, CA; Bianchine, JR; Gerber, N; Kershaw, RA; Mays, DC; Sharp, DE | 1 |
| Cassell, S; Dromgoole, SH; Furst, DE; Paulus, HE | 1 |
| Mamolo, MG; Maurich, V; Pitotti, A | 1 |
| Kitagawa, H; Masumura, H; Saito, H; Sakai, T; Takeno, S; Ueno, K; Yokoyama, A | 1 |
| Azaroual, N; Imbenotte, M; Leclerc, F; Lhermitte, M; Maschke, S; Vermeersch, G | 1 |
| Bttner, T; Gerlach, M; Kuhn, W; Müller, T | 1 |
| Coudray, C; Fatôme, M; Favier, A; Martin, S; Talla, M | 1 |
| Castañeda-Hernández, G; Castillo-Méndez, MS; Flores-Murrieta, FJ; Granados-Soto, V; López-Muñoz, FJ | 1 |
| Goto, S; Matsumoto, Y; Ohsako, M | 1 |
| Bissell, MG; Mohammad, AA; Petersen, JR | 1 |
| Aghabeigi, B; Haque, M; Harris, M; Henderson, B; Hodges, SJ; Wasil, M | 1 |
| Bjørnsdottir, I; Hansen, SH; Jensen, ME | 1 |
| Carbajal-Rodríguez, L; Flores-Pérez, J; Juárez-Olguín, H; Lares-Asseff, I; Loredo-Abdalá, A; Ramírez-Lacayo, M | 1 |
| Gmeiner, B; Held, I; Hermann, M; Hofbauer, R; Kapiotis, S; Seelos, C | 1 |
| Exner, M; Gmeiner, BM; Held, I; Hermann, M; Hofbauer, R; Kapiotis, S; Seelos, C; Speiser, W | 1 |
| Brune, K; Hinz, B; Kraus, V; Pahl, A | 1 |
| Sweedler, J; Thormann, W; Zaugg, S; Zhang, X | 1 |
| Khan, W; Prithiviraj, B; Smith, DL | 1 |
| HABERLAND, GL; MEDENWALD, H | 1 |
| CHRISTIAN, JE; CRABTREE, RE; DATA, JB | 1 |
| Carbajal Rodríguez, L; Flores Pérez, J; Juárez Olguín, H; Lares Asseff, I; Loredo Abdalá, A | 1 |
| BALOUEFF, S | 1 |
| Abrantes, N; Gonçalves, F; Marques, CR | 1 |
| Ashidate, K; Hirata, Y; Kawamura, M; Mimura, D; Miyazaki, S; Teramoto, T; Tohda, H; Yamamoto, Y | 1 |
| Campbell, BC; Chan, KL; Kim, JH; Mahoney, N; May, GS; Molyneux, RJ | 1 |
| Angulo, J; Canales-Mayordomo, A; Cuevas, P; Fernández, IS; Giménez-Gallego, G; González-Corrochano, R; Jiménez-Barbero, J; López-Navajas, P; Lozano, RM; Romero, A; Valverde, S | 1 |
| Chen, DM; Huang, LL; Ihsan, A; Wang, X; Yuan, ZH | 1 |
| Alañón Molina, A; Martínez Ferreras, F; Murillo Pulgarín, JA | 1 |
| Aldalati, AM; AlTinawi, BM; Azouz, HJ; Ganguly, P; Juurlink, BH | 1 |
| Goyal, RN; Gupta, P; Purushotham, M | 1 |
| Altinoz, MA; Cengiz, S; Elmaci, I; Emekli-Alturfan, E; Ozpinar, A | 1 |
| Altinoz, MA; Ozpinar, A | 1 |
| Abedi, F; Hosseinzadeh, H; Razavi, BM | 1 |
| Ejima, Y; Hirakawa, E; Hosokawa, S; Morinishi, T; Ohsaki, H; Shimosawa, T; Shukuya, K; Sogabe, K; Tokuhara, Y | 1 |
| Bhat, GJ; Kumar, DR; Patel, J; Sankaranarayanan, R | 1 |
4 review(s) available for aspirin and 2,5-dihydroxybenzoic acid
| Article | Year |
|---|---|
Hydroxybenzoic acid isomers and the cardiovascular system.
Topics: Aspirin; Benzyl Alcohols; Cardiovascular System; Diet; Gentisates; Glucosides; Humans; Hydroxybenzoates; Isothiocyanates; Oxidative Stress; Phytochemicals; Sulfoxides | 2014 |
Acetylsalicylic acid and its metabolite gentisic acid may act as adjunctive agents in the treatment of psychiatric disorders.
Topics: Anti-Inflammatory Agents; Antioxidants; Aspirin; Bipolar Disorder; Gentisates; Humans; Inflammation; Mental Disorders; Oxidation-Reduction; Oxidative Stress; Schizophrenia | 2019 |
A review on gentisic acid as a plant derived phenolic acid and metabolite of aspirin: Comprehensive pharmacology, toxicology, and some pharmaceutical aspects.
Topics: Animals; Antioxidants; Aspirin; Fruit; Gentisates; Hibiscus; Humans; Hydroxybenzoates; Olea; Phytotherapy; Plant Extracts; Vitis | 2020 |
Do Aspirin and Flavonoids Prevent Cancer through a Common Mechanism Involving Hydroxybenzoic Acids?-The Metabolite Hypothesis.
Topics: Animals; Aspirin; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Flavonoids; Fruit; Gallic Acid; Gentisates; Humans; Hydroxybenzoates; MAP Kinase Signaling System | 2020 |
2 trial(s) available for aspirin and 2,5-dihydroxybenzoic acid
| Article | Year |
|---|---|
Analytical determination and pharmacokinetics of major metabolites of carbasalate calcium in broilers following oral administration.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chickens; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drug Administration Schedule; Female; Gentisates; Male; Salicylic Acid; Tandem Mass Spectrometry; Urea | 2011 |
Graphene modified glassy carbon sensor for the determination of aspirin metabolites in human biological samples.
Topics: Adult; Aspirin; Carbon; Dielectric Spectroscopy; Electrodes; Female; Gentisates; Humans; Hydroxybenzoates; Limit of Detection; Male; Microscopy, Electron, Scanning; Young Adult | 2015 |
40 other study(ies) available for aspirin and 2,5-dihydroxybenzoic acid
| Article | Year |
|---|---|
Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells.
Topics: Amino Acid Substitution; Benzyl Alcohols; Cell Membrane; Goiter, Nodular; Hearing Loss, Sensorineural; HEK293 Cells; Humans; Membrane Transport Proteins; Microscopy, Fluorescence; Salicylates; Sulfate Transporters | 2017 |
Demonstration of the formation of hydroxyl radicals in acute myocardial infarction in man using salicylate as probe.
Topics: Aspirin; Chromatography, High Pressure Liquid; Female; Free Radicals; Gentisates; Humans; Hydroxides; Hydroxybenzoates; Hydroxyl Radical; Isosorbide Dinitrate; Male; Middle Aged; Myocardial Infarction; Tissue Plasminogen Activator | 1992 |
Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients.
Topics: Adult; Aspirin; Diabetes Mellitus, Type 1; Female; Gentisates; Humans; Hydroxybenzoates; Hydroxylation; Male; Oxidation-Reduction; Reactive Oxygen Species; Salicylates; Thiobarbiturates | 1992 |
Simultaneous high-performance liquid chromatographic determination of salicylates in whole blood, plasma and isolated erythrocytes.
Topics: Animals; Aspirin; Cells, Cultured; Chromatography, High Pressure Liquid; Erythrocytes; Gentisates; Hippurates; Hydroxybenzoates; Rabbits; Reproducibility of Results; Salicylates; Salicylic Acid; Spectrophotometry, Ultraviolet | 1992 |
Gentisic acid: an aspirin metabolite with multiple effects on human blood polymorphonuclear leukocytes.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Calcimycin; Cell Aggregation; Depression, Chemical; Fluorescence Polarization; Gentisates; Humans; Hydroxybenzoates; Membrane Fluidity; Neutrophils; Superoxides | 1986 |
Heterogeneity of changes on the disposition of aspirin in rats with CCl4-induced chronic liver damage.
Topics: Aniline Hydroxylase; Animals; Aspirin; Carbon Tetrachloride; Carboxylic Ester Hydrolases; Colchicine; Gentisates; Glucuronates; Glucuronosyltransferase; Hydroxybenzoates; Kinetics; Liver; Liver Cirrhosis, Experimental; Male; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid | 1987 |
2,3-Dihydroxybenzoic acid is a product of human aspirin metabolism.
Topics: Aspirin; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Gentisates; Humans; Hydroxybenzoates; Kinetics; Mass Spectrometry | 1988 |
Salicylates and 12-lipoxygenase activity in human washed platelets.
Topics: Adult; Arachidonate 12-Lipoxygenase; Arachidonate Lipoxygenases; Aspirin; Blood Platelets; Chromatography, High Pressure Liquid; Gentisates; Humans; Hydroxybenzoates; In Vitro Techniques; Lipoxygenase Inhibitors; Salicylamides; Salicylates; Salicylic Acid | 1986 |
Differences in the haemorrhagic toxicity of aspirin between rats and mice.
Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Gastrointestinal Hemorrhage; Gentisates; Hydroxybenzoates; Kaolin; Liver; Male; Mice; Mice, Inbred ICR; Organ Size; Partial Thromboplastin Time; Prothrombin Time; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Species Specificity; Time Factors | 1985 |
Plasma and synovial fluid concentrations of salicylic acid and its metabolites in patients with joint effusions.
Topics: Adult; Aged; Arthritis; Aspirin; Female; Gentisates; Hippurates; Humans; Hydroxybenzoates; Male; Middle Aged; Salicylates; Salicylic Acid; Synovial Fluid | 1985 |
Aspirin metabolites causing misinterpretation of paracetamol results.
Topics: Acetaminophen; Aspirin; Biotransformation; Chromatography, High Pressure Liquid; Gentisates; Humans; Hydroxybenzoates; Infant; Male; Salicylates; Salicylic Acid | 1984 |
Improved method for the determination of aspirin and its metabolites in biological fluids by high-performance liquid chromatography: applications to human and animal studies.
Topics: Animals; Aspirin; Biological Availability; Chromatography, High Pressure Liquid; Gentisates; Hippurates; Humans; Hydroxybenzoates; Kinetics; Rabbits; Rats; Salicylates; Salicylic Acid; Species Specificity | 1984 |
Availability of salicylate from salsalate and aspirin.
Topics: Arthritis, Rheumatoid; Aspirin; Biological Availability; Chromatography, High Pressure Liquid; Double-Blind Method; Drug Evaluation; Female; Gentisates; Humans; Hydroxybenzoates; Male; Salicylates; Salicylic Acid | 1983 |
[HPLC determination of gentisic acid in urine of subjects treated with aspirin].
Topics: Aspirin; Chromatography, High Pressure Liquid; Gentisates; Humans; Hydroxybenzoates | 1983 |
Fetal toxicity and hypocalcemia induced by acetylsalicylic acid analogues.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Female; Fetus; Gentisates; Hydroxybenzoates; Hypocalcemia; Male; Mice; Mice, Inbred Strains; Pregnancy; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1982 |
Salicylate poisoning: two-dimensional J-resolved NMR urinalysis.
Topics: Adolescent; Aspirin; Female; Gentisates; Hippurates; Humans; Hydroxybenzoates; Magnetic Resonance Spectroscopy; Poisoning; Salicylates; Salicylic Acid | 1995 |
Aspirin as a free radical scavenger: consequences for therapy of cerebrovascular ischemia.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Cerebrovascular Disorders; Cyclooxygenase Inhibitors; Female; Free Radical Scavengers; Gentisates; Humans; Hydroxybenzoates; Male; Neuroprotective Agents; Platelet Aggregation Inhibitors; Salicylates; Salicylic Acid | 1995 |
High-performance liquid chromatography-electrochemical determination of salicylate hydroxylation products as an in vivo marker of oxidative stress.
Topics: Adult; Aspirin; Calibration; Chromatography, High Pressure Liquid; Female; Free Radical Scavengers; Gentisates; Humans; Hydroxybenzoates; Hydroxyl Radical; Male; Oxidative Stress; Reproducibility of Results; Salicylates; Salicylic Acid; Thiobarbituric Acid Reactive Substances | 1995 |
Potentiation by caffeine of the analgesic effect of aspirin in the pain-induced functional impairment model in the rat.
Topics: Animals; Aspirin; Caffeine; Drug Synergism; Female; Gentisates; Hindlimb; Hydroxybenzoates; Pain; Rats; Rats, Wistar; Salicylates; Salicylic Acid | 1994 |
Transport of aspirin and its metabolites through human erythrocyte membrane.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Aspirin; Chemical Phenomena; Chemistry, Physical; Culture Media; Cytosol; Erythrocyte Membrane; Gentisates; Hippurates; Humans; Hydrolysis; Hydroxybenzoates; In Vitro Techniques; Salicylates; Salicylic Acid | 1993 |
Laser induced resonance energy transfer--a novel approach towards achieving high sensitivity in capillary electrophoresis. I. Clinical diagnostic application.
Topics: Aminosalicylic Acid; Aspirin; Benzoates; Chemistry, Clinical; Electrophoresis, Capillary; Energy Transfer; Gentisates; Hippurates; Humans; Hydroxybenzoates; Lasers; Linear Models; Salicylates; Sensitivity and Specificity | 1996 |
The role of oxygen free radicals in idiopathic facial pain.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Chronic Disease; Cytokines; Dinoprostone; Facial Pain; Female; Free Radicals; Gentisates; Humans; Hydroxybenzoates; Hydroxyeicosatetraenoic Acids; Iron Chelating Agents; Leukotriene B4; Male; Mastication; Middle Aged; Reactive Oxygen Species; Synovial Fluid; Temporomandibular Joint; Temporomandibular Joint Dysfunction Syndrome; Thiobarbituric Acid Reactive Substances | 1997 |
Assay of acetylsalicylic acid and three of its metabolites in human plasma and urine using non-aqueous capillary electrophoresis with reversed electroosmotic flow.
Topics: Acetonitriles; Aspirin; Electrophoresis, Capillary; Gentisates; Hexadimethrine Bromide; Hippurates; Humans; Hydrogen-Ion Concentration; Hydroxybenzoates; In Vitro Techniques; Methanol; Osmosis; Reproducibility of Results; Salicylic Acid; Temperature | 1998 |
Influence of nutritional status on the pharmacokinetics of acetylsalicylic acid and its metabolites in children with autoimmune disease.
Topics: Adolescent; Anthropometry; Area Under Curve; Aspirin; Autoimmune Diseases; Biotransformation; Body Weight; Child; Child, Preschool; Gentisates; Hippurates; Humans; Hydroxybenzoates; Nutritional Status; Prospective Studies; Regression Analysis | 1999 |
Salicylate promotes myeloperoxidase-initiated LDL oxidation: antagonization by its metabolite gentisic acid.
Topics: Arteriosclerosis; Aspirin; Free Radical Scavengers; Free Radicals; Gentisates; Humans; Hydroxybenzoates; In Vitro Techniques; Lipid Peroxidation; Lipoproteins, LDL; Neutrophils; Oxidants; Oxidation-Reduction; Peroxidase; Phenols; Salicylic Acid; Tyrosine | 1999 |
The salicylate metabolite gentisic acid, but not the parent drug, inhibits glucose autoxidation-mediated atherogenic modification of low density lipoprotein.
Topics: Arteriosclerosis; Aspirin; Cells, Cultured; Diabetic Angiopathies; Endothelium, Vascular; Gentisates; Glucose; Humans; Hydroxybenzoates; Iron Chelating Agents; Lipoproteins, LDL; Male; Oxidation-Reduction; Prodrugs; Reactive Oxygen Species; Salicylic Acid; Thromboplastin | 2000 |
Salicylate metabolites inhibit cyclooxygenase-2-dependent prostaglandin E(2) synthesis in murine macrophages.
Topics: Acyl Coenzyme A; Animals; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Gentisates; Hydroxybenzoates; Inflammation; Isoenzymes; Lipopolysaccharides; Macrophages; Mice; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Salicylates; Sodium Salicylate | 2000 |
Determination of salicylate, gentisic acid and salicyluric acid in human urine by capillary electrophoresis with laser-induced fluorescence detection.
Topics: Aspirin; Electrophoresis, Capillary; Gentisates; Hippurates; Humans; Hydroxybenzoates; Immunoassay; Spectrometry, Fluorescence | 2001 |
Photosynthetic responses of corn and soybean to foliar application of salicylates.
Topics: Aspirin; Chlorophyll; Gases; Gentisates; Glycine max; Hydroxybenzoates; Molecular Structure; Phenols; Photosynthesis; Plant Leaves; Salicylates; Zea mays | 2003 |
[Metabolic studies on drugs. I. Synthesis of radiocarbon labelled salicylic acid (carboxy-C14), acetetylsalicylic acid (carboxy-C14 & acetyl-1-C14), salicyluric acid (carbamyl-C14), and gentisic acid (carboxy-C14)].
Topics: Aspirin; Gentisates; Hippurates; Salicylates; Uric Acid | 1957 |
A study of the oxidative metabolism of acetylsalicylic, salicylic, and gentisic acid in fevered animals.
Topics: Animals; Aspirin; Fever; Gentisates; Salicylates; Salicylic Acid | 1958 |
Comparative pharmacokinetics of acetyl salicylic acid and its metabolites in children suffering from autoimmune diseases.
Topics: Administration, Oral; Adolescent; Area Under Curve; Arthritis, Juvenile; Aspirin; Autoimmune Diseases; Biological Availability; Child; Chromatography, High Pressure Liquid; Female; Gentisates; Half-Life; Hippurates; Humans; Male; Mexico; Prospective Studies; Rheumatic Fever; Salicylic Acid; Tablets | 2004 |
[Comparison of the antipyretic effect of N. acetylsalicylamide, amidofebrine, acetylsalicylic acid, gentisic acid and antipyrine].
Topics: Antipyretics; Antipyrine; Aspirin; Gentisates; Salicylates | 1950 |
Life-history traits of standard and autochthonous cladocerans: II. Acute and chronic effects of acetylsalicylic acid metabolites.
Topics: Animals; Aspirin; Cladocera; Daphnia; Female; Fresh Water; Gentisates; Hippurates; Male; No-Observed-Adverse-Effect Level; Portugal; Reproduction; Salicylic Acid; Toxicity Tests, Acute; Toxicity Tests, Chronic; Water Pollutants, Chemical | 2004 |
Gentisic acid, an aspirin metabolite, inhibits oxidation of low-density lipoprotein and the formation of cholesterol ester hydroperoxides in human plasma.
Topics: Antioxidants; Aspirin; Azo Compounds; Cell Line; Chelating Agents; Cholesterol Esters; Dose-Response Relationship, Drug; Ferrous Compounds; Free Radical Scavengers; Gentisates; Humans; In Vitro Techniques; Lipid Peroxides; Lipoproteins, LDL; Nitriles; Oxidation-Reduction | 2005 |
Enhancement of fludioxonil fungicidal activity by disrupting cellular glutathione homeostasis with 2,5-dihydroxybenzoic acid.
Topics: Antifungal Agents; Aspergillus flavus; Aspergillus fumigatus; Aspirin; Dioxoles; Drug Synergism; Gentisates; Glutathione; Homeostasis; MAP Kinase Signaling System; Microbial Sensitivity Tests; Mitogen-Activated Protein Kinases; Mutation; Pyrroles; Structure-Activity Relationship | 2007 |
Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding, Competitive; Cell Movement; Drug Design; Extracellular Matrix; Fibroblast Growth Factors; Gentisates; Heparin; Mice; Mice, Inbred BALB C; Mitogens; NIH 3T3 Cells | 2010 |
Application of time-resolved fluorescence to the determination of metabolites.
Topics: Aspirin; Gentisates; Humans; Salicylic Acid; Spectrometry, Fluorescence; Urine | 2014 |
From epidemiology to treatment: Aspirin's prevention of brain and breast-cancer and cardioprotection may associate with its metabolite gentisic acid.
Topics: Animals; Aspirin; Brain Neoplasms; Breast Neoplasms; Carcinoma, Ehrlich Tumor; Cardiotonic Agents; Cell Line, Tumor; Cell Proliferation; Female; Gentisates; Male; Mice, Inbred BALB C; Myocardium; S Phase; Sodium Selenite; Survival Analysis | 2018 |
Novel absorbance peak of gentisic acid following the oxidation reaction.
Topics: Alkaptonuria; Aspirin; Chromatography, Liquid; Gentisates; Homogentisic Acid; Humans; Mass Spectrometry; Oxidants; Oxidation-Reduction; Sodium Hydroxide; Sodium Hypochlorite; Spectrophotometry | 2020 |