Compounds > aspirin

aspirin and 15-hydroxy-5,8,11,13-eicosatetraenoic acid

aspirin has been researched along with 15-hydroxy-5,8,11,13-eicosatetraenoic acid in 44 studies

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19907 (15.91)18.7374
1990's18 (40.91)18.2507
2000's10 (22.73)29.6817
2010's8 (18.18)24.3611
2020's1 (2.27)2.80

Authors

AuthorsStudies
Bulbena, O; Gelpí, E; Montserrat, JM; Picado, C; Plaza, V; Prat, J; Ramis, I; Rosellò, J1
Holtzman, MJ; Shornick, LP; Turk, J1
Peskar, BA; Peskar, BM; Trautmann, M1
Herman, AG; Van Diest, MJ; Verbeuren, TJ1
Beckman, BS; Fisher, JW; King, L; Mason-Garcia, M; Nystuen, L1
Crittenden, N; Fitzpatrick, F; McGee, J; McGuire, J1
Setty, BN; Stuart, MJ; Walenga, RW1
Kawakita, S; Nozaki, M; Ozaki, N; Saeki, Y; Takahashi, M1
Bailey, JM; Bryant, RW; Fletcher-Cieutat, M; Vanderhoek, JY1
Bailey, JM; Goldstein, AL; Oliver, JH; Skotnicki, A; Zatz, MM1
Breviario, F; de Castellarnau, C; López, S; Vila, L1
Ferreri, NR; Mahboubi, K1
Abramovitz, M; Cromlish, W; Falgueyret, JP; Kargman, S; Kennedy, BP; Kwan, MY; Mancini, JA; O'Neill, GP; Ouellet, M; Yergey, J1
Bayly, C; Mancini, JA; O'Neill, GP; Vickers, PJ1
DeWitt, DL; Ji, C; Laneuville, O; Lecomte, M; Smith, WL1
DeWitt, DL; Meade, EA; Smith, WL1
Boily, C; Falgueyret, JP; Mancini, JA; O'Neill, GP; Riendeau, D; Vickers, PJ1
Copeland, RA; Penning, TM; Tang, MS1
Aghabeigi, B; Haque, M; Harris, M; Henderson, B; Hodges, SJ; Wasil, M1
Everson, WV; Johnson, RD; Nelson, DM; Polakoski, K1
Dalsgaard, CJ; Haegerstrand, A; Martinsson, T1
Huang, X; Johnson, RD; Nelson, DM; Polakoski, KL; Sadovsky, Y1
Hippenstiel, S; Jahn, HU; Klockmann, MT; Krämer, HJ; Suttorp, N1
Sarbia, M; Schrör, K; Weber, AA; Zimmermann, KC1
Chiang, N; Clària, J; Gaya, J; Pueyo, G; Romano, M; Serhan, CN; Titos, E1
Brash, AR; Schneider, C1
Iwaszkiewicz, J; Kaliner, MA; Kornatowski, T; Kowalski, ML; Pawliczak, R; Poniatowska, M; Siuda, K; Wozniak, J1
Crews, BC; Gierse, JK; Goodwin, DC; Marnett, LJ; Rowlinson, SW; Schneider, C1
Ikeda, U; Maeda, Y; Murakami, Y; Ohya, K; Shimada, K; Shimpo, M1
Chiang, N; Clish, CB; Gronert, K; Levy, BD; Mastalerz, L; Sanak, M; Serhan, CN; Szczeklik, A1
Dadaian, M; Westlund, P1
Bienkiewicz, B; DuBuske, L; Kowalski, ML; Pawliczak, R; Ptasinska, A1
Sakakibara, H; Yoneda, Y1
Bienkiewicz, B; Cieslak, M; Dubuske, L; Grzegorczyk, J; Jedrzejczak, M; Kowalski, ML; Pawliczak, R; Ptasinska, A1
Borowiec, M; Kowalski, ML; Kurowski, M; Pawliczak, R1
Chiamvimonvat, N; Hammock, BD; Hwang, SH; Inceoglu, B; Liu, JY; Qiu, H; Ulu, A; Yang, J1
Bajrovic, N; Korosec, P; Kosnik, M; Mrhar, A; Silar, M; Tisler, U1
Jankowski, A; Jarzebska, M; Jedrzejczak-Czechowicz, M; Kowalski, ML; Lewandowska-Polak, A; Makowska, JS1
Backman, L; Brunnström, A; Claesson, HE; Daham, K; Dahlén, B; Dahlén, SE; Edenius, C; James, A; Kumlin, M; Tingvall, T1
Dennis, EA; Glass, CK; Gosselin, D; Norris, PC; Reichart, D1
Edin, ML; Kirkby, NS; Mitchell, JA; Rauzi, F; Warner, TD; Whiteford, J; Zeldin, DC1
Boeglin, WE; Boutaud, O; Giménez-Bastida, JA; Malkowski, MG; Schneider, C1
Anderson, AJ; Dong, L; Malkowski, MG1
Badrani, JH; Cavagnero, K; Christiansen, SC; Deconde, A; Doherty, TA; Eastman, JJ; Kim, AS; Strohm, A; White, AA; Yan, C; Zuraw, BL1

Reviews

1 review(s) available for aspirin and 15-hydroxy-5,8,11,13-eicosatetraenoic acid

ArticleYear
[Aspirin-induced asthma (AIA)].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cyclooxygenase Inhibitors; Dinoprostone; Eosinophils; Humans; Hydroxyeicosatetraenoic Acids; Leukotrienes; Lipoxins; Mast Cells; Prostaglandin-Endoperoxide Synthases

2005

Trials

2 trial(s) available for aspirin and 15-hydroxy-5,8,11,13-eicosatetraenoic acid

ArticleYear
Release of peptide leukotriene into nasal secretions after local instillation of aspirin in aspirin-sensitive asthmatic patients.
    The American review of respiratory disease, 1992, Volume: 145, Issue:1

    Topics: Administration, Intranasal; Adult; Albumins; Aspirin; Asthma; Dinoprost; Dinoprostone; Drug Hypersensitivity; Female; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Leukotrienes; Male; Middle Aged; Nasal Mucosa; Prostaglandin D2

1992
Acetylsalicylic acid-triggered 15-HETE generation by peripheral leukocytes for identifying ASA sensitivity.
    Respiratory medicine, 2011, Volume: 105 Suppl 1

    Topics: Aspirin; Drug Hypersensitivity; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydroxyeicosatetraenoic Acids; Leukocytes; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Sensitivity and Specificity; Single-Blind Method

2011

Other Studies

41 other study(ies) available for aspirin and 15-hydroxy-5,8,11,13-eicosatetraenoic acid

ArticleYear
Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells.
    The Journal of biological chemistry, 1992, Oct-25, Volume: 267, Issue:30

    Topics: Amino Acid Sequence; Animals; Aspirin; Cells, Cultured; Cyclooxygenase Inhibitors; Electrophoresis, Polyacrylamide Gel; Epithelial Cells; Epithelium; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Molecular Sequence Data; Precipitin Tests; Prostaglandin Antagonists; Prostaglandin-Endoperoxide Synthases; Sheep; Trachea

1992
Aspirin-like drugs, ethanol-induced rat gastric injury and mucosal eicosanoid release.
    European journal of pharmacology, 1991, Aug-16, Volume: 201, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Relationship, Drug; Eicosanoids; Ethanol; Gastric Mucosa; Hydroxyeicosatetraenoic Acids; Male; Radioimmunoassay; Rats; Rats, Inbred Strains; SRS-A

1991
Cyclo-oxygenase blockers influence the effects of 15-lipoxygenase metabolites of arachidonic acid in isolated canine blood vessels.
    Prostaglandins, 1986, Volume: 32, Issue:1

    Topics: Animals; Arachidonate 15-Lipoxygenase; Arachidonate Lipoxygenases; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Dogs; Hydroxyeicosatetraenoic Acids; Indomethacin; Leukotrienes; Lipid Peroxides; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine

1986
The action of erythropoietin is mediated by lipoxygenase metabolites in murine fetal liver cells.
    Biochemical and biophysical research communications, 1987, Aug-31, Volume: 147, Issue:1

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Butylated Hydroxyanisole; Erythropoiesis; Erythropoietin; Hydroxyeicosatetraenoic Acids; Liver; Masoprocol; Meclofenamic Acid; Mice; Phosphatidylinositols; Pyrazoles

1987
Cell damage unmasks 15-lipoxygenase activity in human neutrophils.
    The Journal of biological chemistry, 1985, Jul-15, Volume: 260, Issue:14

    Topics: Acetates; Arachidonate Lipoxygenases; Aspirin; Dose-Response Relationship, Drug; Etodolac; Fluorometry; Flurbiprofen; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; L-Lactate Dehydrogenase; Lipoxygenase; Naproxen; Neutrophils; Phenylbutazone

1985
Formation of 11-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid in human umbilical arteries is catalyzed by cyclooxygenase.
    Biochimica et biophysica acta, 1985, Mar-06, Volume: 833, Issue:3

    Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Catechols; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Infant, Newborn; Masoprocol; Prostaglandin-Endoperoxide Synthases; Subcellular Fractions; Umbilical Arteries

1985
Vascular effects of 15-hydroperoxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid on canine arteries.
    Japanese journal of pharmacology, 1985, Volume: 37, Issue:4

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arteries; Aspirin; Cerebral Angiography; Cerebral Arteries; Coronary Vessels; Dogs; Hydroxyeicosatetraenoic Acids; Imidazoles; In Vitro Techniques; Leukotrienes; Lipid Peroxides; Male; Tranylcypromine; Vasoconstrictor Agents

1985
Aspirin enhances the sensitivity of human platelet 12-lipoxygenase to inhibition by 15-HETE, an endogenous regulator.
    Prostaglandins, leukotrienes, and medicine, 1985, Volume: 18, Issue:2

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonate Lipoxygenases; Aspirin; Blood Platelets; Drug Synergism; Humans; Hydroxyeicosatetraenoic Acids; Lipoxygenase Inhibitors

1985
Mechanism of action of thymosin. II. Effects of aspirin and thymosin on enhancement of IL-2 production.
    Immunopharmacology, 1985, Volume: 9, Issue:3

    Topics: Aspirin; Humans; Hydroxyeicosatetraenoic Acids; Interleukin-2; Lipoxygenase; Monocytes; Prostaglandin-Endoperoxide Synthases; Thymosin

1985
Interleukin-1 increases 15-hydroxyeicosatetraenoic acid formation in cultured human endothelial cells.
    Biochimica et biophysica acta, 1993, Sep-29, Volume: 1170, Issue:1

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Arachidonate 15-Lipoxygenase; Arachidonic Acid; Aspirin; Base Sequence; Carbon Radioisotopes; Cells, Cultured; Endothelium; Gene Expression; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Interleukin-1; Masoprocol; Molecular Sequence Data; Monocytes; Polymerase Chain Reaction; Recombinant Proteins; RNA; RNA, Messenger

1993
Production of PGE2 and 15-HETE by fibrosarcoma cells.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: Animals; Arachidonic Acid; Aspirin; Calcimycin; Carbon Radioisotopes; Cell Line; Chromatography, High Pressure Liquid; Dinoprostone; Fibrosarcoma; Gene Expression; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Interleukin-1; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1995
Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid.
    Molecular pharmacology, 1994, Volume: 45, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Base Sequence; Cell Line; Chromatography, High Pressure Liquid; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Humans; Hydroxyeicosatetraenoic Acids; Immunoblotting; Microsomes; Molecular Sequence Data; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Vaccinia virus

1994
Mutation of serine-516 in human prostaglandin G/H synthase-2 to methionine or aspirin acetylation of this residue stimulates 15-R-HETE synthesis.
    FEBS letters, 1994, Mar-28, Volume: 342, Issue:1

    Topics: Acetylation; Animals; Aspirin; Cell Line; Humans; Hydroxyeicosatetraenoic Acids; Methionine; Microsomes; Mutagenesis, Site-Directed; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Serine

1994
Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin.
    The Journal of biological chemistry, 1994, May-06, Volume: 269, Issue:18

    Topics: Acetylation; Aspirin; Base Sequence; Cell Line; Cyclooxygenase Inhibitors; Humans; Hydroxyeicosatetraenoic Acids; Isoenzymes; Molecular Sequence Data; Oligodeoxyribonucleotides

1994
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.
    The Journal of biological chemistry, 1993, Mar-25, Volume: 268, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cyclooxygenase Inhibitors; Hydroxyeicosatetraenoic Acids; Indomethacin; Isoenzymes; Kinetics; Mice; Prostaglandin-Endoperoxide Synthases

1993
Altered sensitivity of aspirin-acetylated prostaglandin G/H synthase-2 to inhibition by nonsteroidal anti-inflammatory drugs.
    Molecular pharmacology, 1997, Volume: 51, Issue:1

    Topics: Acetylation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; COS Cells; Cyclooxygenase Inhibitors; Dinoprostone; Hydroxyeicosatetraenoic Acids; Prostaglandin-Endoperoxide Synthases

1997
Detection of an Fe2+-protoporphyrin-IX intermediate during aspirin-treated prostaglandin H2 synthase II catalysis of arachidonic acid to 15-HETE.
    Biochemistry, 1997, Jun-17, Volume: 36, Issue:24

    Topics: Arachidonic Acid; Aspirin; Catalysis; Cyclooxygenase Inhibitors; Ferrous Compounds; Humans; Hydrogen Peroxide; Hydroxyeicosatetraenoic Acids; Isoenzymes; Kinetics; Oxygen Consumption; Prostaglandin-Endoperoxide Synthases; Protoporphyrins; Recombinant Proteins; Spectrum Analysis

1997
The role of oxygen free radicals in idiopathic facial pain.
    The British journal of oral & maxillofacial surgery, 1997, Volume: 35, Issue:3

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Chronic Disease; Cytokines; Dinoprostone; Facial Pain; Female; Free Radicals; Gentisates; Humans; Hydroxybenzoates; Hydroxyeicosatetraenoic Acids; Iron Chelating Agents; Leukotriene B4; Male; Mastication; Middle Aged; Reactive Oxygen Species; Synovial Fluid; Temporomandibular Joint; Temporomandibular Joint Dysfunction Syndrome; Thiobarbituric Acid Reactive Substances

1997
Aspirin induces increased expression of both prostaglandin H synthase-1 and prostaglandin H synthase-2 in cultured human placental trophoblast.
    American journal of obstetrics and gynecology, 1997, Volume: 177, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cells, Cultured; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Humans; Hydroxyeicosatetraenoic Acids; Isomerism; Platelet Aggregation Inhibitors; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Synthesis Inhibitors; Radioimmunoassay; Thromboxane B2; Time Factors; Trophoblasts

1997
Effects of ropivacaine on eicosanoid release from human granulocytes and endothelial cells in vitro.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46, Issue:10

    Topics: 6-Ketoprostaglandin F1 alpha; Amides; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Eicosanoids; Endothelium, Vascular; Granulocytes; Humans; Hydrocortisone; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Lidocaine; Mesalamine; Ropivacaine; Thrombin; Zymosan

1997
The release of 15-hydroxyeicosatetraenoic acid by human placental trophoblast is increased in preeclampsia.
    American journal of obstetrics and gynecology, 1998, Volume: 178, Issue:1 Pt 1

    Topics: Aspirin; Cells, Cultured; Cyclooxygenase Inhibitors; Female; Humans; Hydroxyeicosatetraenoic Acids; Isoenzymes; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; Pre-Eclampsia; Pregnancy; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Time Factors; Trophoblasts

1998
Interaction of human neutrophils with airway epithelial cells: reduction of leukotriene B4 generation by epithelial cell derived prostaglandin E2.
    Journal of cellular physiology, 1998, Volume: 175, Issue:3

    Topics: Animals; Aspirin; Bronchi; Cell Communication; Cells, Cultured; Coculture Techniques; Dinoprostone; Epithelial Cells; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Leukotrienes; Neutrophils; Superoxides; Swine; Trachea

1998
Constitutive cyclooxygenase-2 expression in healthy human and rabbit gastric mucosa.
    Molecular pharmacology, 1998, Volume: 54, Issue:3

    Topics: Animals; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Induction; Fibroblasts; Gastric Mucosa; Humans; Hydroxyeicosatetraenoic Acids; Indans; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Muscle, Smooth; Prostaglandin-Endoperoxide Synthases; Rabbits; RNA, Messenger

1998
Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4).
    The American journal of physiology, 1999, Volume: 277, Issue:5

    Topics: Animals; Aspirin; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Activation; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Ibuprofen; Indomethacin; Isoenzymes; Lipoxins; Liver; Male; Membrane Proteins; Phenobarbital; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Thromboxane B2

1999
Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site.
    The Journal of biological chemistry, 2000, Feb-18, Volume: 275, Issue:7

    Topics: Acetylation; Arachidonic Acid; Aspirin; Binding Sites; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Hydrogen; Hydroxyeicosatetraenoic Acids; Isoenzymes; Models, Chemical; Prostaglandin-Endoperoxide Synthases; Substrate Specificity

2000
Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients.
    American journal of respiratory and critical care medicine, 2000, Volume: 161, Issue:2 Pt 1

    Topics: Adult; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Asthma; Cattle; Cells, Cultured; Dinoprostone; Drug Hypersensitivity; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Middle Aged; Nasal Polyps; Prostaglandin D2; Respiratory Mucosa

2000
Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete.
    The Journal of biological chemistry, 2000, Mar-03, Volume: 275, Issue:9

    Topics: Acetylation; Animals; Arachidonic Acid; Aspirin; Binding Sites; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Hydroxyeicosatetraenoic Acids; Isoenzymes; Membrane Proteins; Mice; Models, Molecular; Mutagenesis, Site-Directed; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Spodoptera

2000
Effects of aspirin-like drugs on nitric oxide synthesis in rat vascular smooth muscle cells.
    Hypertension (Dallas, Tex. : 1979), 2000, Volume: 35, Issue:5

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Dose-Response Relationship, Drug; Hydroxyeicosatetraenoic Acids; Indomethacin; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Sodium Salicylate

2000
Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics.
    The European respiratory journal, 2000, Volume: 16, Issue:1

    Topics: Adult; Aspirin; Asthma; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene C4; Lipoxins; Male; Middle Aged; Stereoisomerism

2000
Substrate down regulation of 12-lipoxygenase in human platelets.
    Advances in experimental medicine and biology, 2002, Volume: 507

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonate 12-Lipoxygenase; Aspirin; Blood Platelets; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Platelet Aggregation Inhibitors

2002
Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients.
    The Journal of allergy and clinical immunology, 2003, Volume: 112, Issue:3

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Dinoprostone; Drug Tolerance; Eicosanoids; Female; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Ionophores; Leukocytes; Leukotriene C4; Lipoxins; Male; Middle Aged; Misoprostol

2003
Aspirin-triggered 15-HETE generation in peripheral blood leukocytes is a specific and sensitive Aspirin-Sensitive Patients Identification Test (ASPITest).
    Allergy, 2005, Volume: 60, Issue:9

    Topics: Adult; Aged; Aspirin; Asthma; Drug Hypersensitivity; Female; Humans; Hydroxyeicosatetraenoic Acids; Immunologic Tests; Leukocytes; Male; Middle Aged; Predictive Value of Tests; Rhinitis; Sinusitis

2005
Alternative splicing of cyclooxygenase-1 gene: altered expression in leucocytes from patients with bronchial asthma and association with aspirin-induced 15-HETE release.
    Allergy, 2007, Volume: 62, Issue:6

    Topics: Adult; Aged; Alternative Splicing; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cyclooxygenase 1; Drug Hypersensitivity; Female; Gene Expression; Humans; Hydroxyeicosatetraenoic Acids; Hypersensitivity; Isoenzymes; Leukocytes; Male; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Tests

2007
Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model.
    Biochemical pharmacology, 2010, Mar-15, Volume: 79, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Aspirin; Benzoates; Blood Pressure; Dose-Response Relationship, Drug; Enzyme Activation; Epoxide Hydrolases; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Indoles; Inflammation; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Prostaglandin-Endoperoxide Synthases; Urea

2010
Lack of association between aspirin-triggered 15-hydroxyeicosatetraenoic acid release and mast cell/eosinophil activation in nasal polyps from aspirin-sensitive patients.
    Journal of investigational allergology & clinical immunology, 2011, Volume: 21, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Arachidonate 15-Lipoxygenase; Aspirin; Calcium Ionophores; Drug Hypersensitivity; Eosinophils; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Mast Cells; Middle Aged; Misoprostol; Nasal Polyps

2011
The influence of aspirin on release of eoxin C4, leukotriene C4 and 15-HETE, in eosinophilic granulocytes isolated from patients with asthma.
    International archives of allergy and immunology, 2013, Volume: 162, Issue:2

    Topics: Adult; Arachidonate 15-Lipoxygenase; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Aspirin; Asthma, Aspirin-Induced; Eosinophils; Female; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene C4; Leukotrienes; Male; Middle Aged; Young Adult

2013
Phospholipase A2 regulates eicosanoid class switching during inflammasome activation.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Sep-02, Volume: 111, Issue:35

    Topics: Animals; Aspirin; Celecoxib; Cell Line, Transformed; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Eicosanoids; Group IV Phospholipases A2; Hydroxyeicosatetraenoic Acids; Inflammasomes; Interleukin-1; Lipidoses; Macrophages; Male; Mice; Mice, Inbred C57BL; Pyrazoles; Receptors, Purinergic P2X7; Signal Transduction; Sulfonamides; Toll-Like Receptor 4

2014
Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016, Volume: 30, Issue:12

    Topics: Aspirin; Blood Platelets; Cells, Cultured; Cyclooxygenase 1; Eicosanoids; Endothelium; Humans; Hydroxyeicosatetraenoic Acids; Neovascularization, Pathologic; Platelet Aggregation

2016
Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylation; Aspirin; Cells, Cultured; Chromatography, Liquid; Cyclooxygenase 2; Dinoprostone; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Leukocytes; Mass Spectrometry; Platelet Aggregation

2019
Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex.
    Biochemistry, 2019, 09-24, Volume: 58, Issue:38

    Topics: Animals; Arachidonic Acid; Arginine; Aspirin; Celecoxib; Crystallography, X-Ray; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Enzyme Assays; Histidine; Hydroxyeicosatetraenoic Acids; Leucine; Mutagenesis, Site-Directed; Recombinant Proteins; Sf9 Cells; Stereoisomerism; Substrate Specificity; Time Factors

2019
Lower serum 15-HETE level predicts nasal ILC2 accumulation during COX-1 inhibition in AERD.
    The Journal of allergy and clinical immunology, 2023, Volume: 152, Issue:5

    Topics: Aspirin; Asthma, Aspirin-Induced; Cyclooxygenase Inhibitors; Eicosanoids; Humans; Hydroxyeicosatetraenoic Acids; Immunity, Innate; Lymphocytes; Nasal Mucosa; Nasal Polyps; Prostaglandins; Sinusitis

2023