aspirin has been researched along with 15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid in 71 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (29.58) | 18.7374 |
| 1990's | 19 (26.76) | 18.2507 |
| 2000's | 22 (30.99) | 29.6817 |
| 2010's | 8 (11.27) | 24.3611 |
| 2020's | 1 (1.41) | 2.80 |
| Authors | Studies |
|---|---|
| Kam, ST; Portoghese, PS | 1 |
| Schirner, M; Taube, C | 2 |
| Inoue, M; Iwane, Y; Kobune, K; Kudo, T; Morikawa, M; Takanami, Y; Tsuboi, M | 1 |
| Karasawa, A; Kubo, K; Shirakura, S | 1 |
| Benjamin, N; Dutton, JA; Ritter, JM | 1 |
| Alonso, MT; Garcia-Sancho, J; Sanchez, A | 1 |
| England, PJ; Hallam, TJ; Maguire, J; Moores, K; Murray, KJ; Reeves, ML; Rink, TJ; Simpson, AW | 1 |
| Disa, J; Kowalska, MA; Rao, AK | 1 |
| Stürzebecher, S; Witt, W | 1 |
| Chenoweth, DE; Engler, RL; Ito, BR; Lefer, AM; Roth, DM | 1 |
| Baker, RC; Fish, HT; Fitzpatrick, FA | 1 |
| Guichardant, M; Lagarde, M; Naltachayan-Durbin, S | 1 |
| Hiller, E; Höfling, B; Riess, H; von Arnim, T | 1 |
| Schrör, K; Verheggen, R | 1 |
| Bertelé, V; Cerletti, C; Chen, ZM; de Gaetano, G | 1 |
| Patscheke, H; Stegmeier, K | 1 |
| Hauser, A; Heinroth-Hoffmann, I; Mest, HJ; Taube, C | 1 |
| Bertelé, V; Castagnoli, MN; Cerletti, C; de Gaetano, G; Rajtar, G | 1 |
| Barbieri, B; Bertelé, V; Bianchi, L; Cerletti, C; de Gaetano, G; Dejana, E; di Minno, G; Silver, MJ | 1 |
| Catalano, PM; De Marco, L; Di Minno, G; Murphy, S; Shapiro, SS | 1 |
| Feuer, C; Johnston, MG | 1 |
| Leĭtin, VL; Mazurov, AB; Repin, VS | 1 |
| Förster, W; Leytin, VL; Mazurov, AV; Repin, VS; Taube, C | 1 |
| Nunn, B | 1 |
| Bertelé, V; Cerletti, C; de Gaetano, G; Di Minno, G; Silver, MJ | 1 |
| Borda, E; del Castillo, E; Gimeno, AL; Gimeno, M; Sterin-Borda, L | 1 |
| Humphrey, PP; Lumley, P | 1 |
| Castiglioni, C; Gazzaniga, PP; Parisi, S; Pignatelli, P; Pulcinelli, FM; Riondino, S | 1 |
| Durham, SK; Megill, JR; Schumacher, WA; Steinbacher, TE | 1 |
| Cooper, J; Hardy, E; Heptinstall, S; Horn, EH; Rubin, PC | 1 |
| Audet, R; Burhop, KE; Drapeau, G; Marceau, F; Rioux, F | 1 |
| Hashimoto, N; Hashimoto, Y; Kurokawa, K; Nakahara, K; Sato, H; Togo, M; Watanabe, T | 1 |
| Feijge, MA; Heemskerk, JW; Hemker, HC; Henneman, L; Rosing, J | 1 |
| Nakayama, K; Shigenobu, K; Tanaka, Y | 1 |
| Alayash, AI; Mondoro, TH; Ryan, BA; Terle, DA; Vostal, JG | 1 |
| Albors, M; Bioque, G; Carretero, M; Díaz Ricart, M; Escolar, G; Garrido, M; Ordinas, A | 1 |
| Ladjevardi, M; Wallén, NH | 1 |
| Ariga, T; Kobayashi, A; Kubota, K; Lim, H; Seki, T | 1 |
| Chamorro, A; Escolar, G; Obach, V; Ordinas, A; Reverter, JC; Revilla, M; Vila, N | 1 |
| Dangelmaier, C; Daniel, JL; Jin, J; Kunapuli, SP; Smith, JB | 1 |
| Del Soldato, P; Emerson, M; Gresele, P; Leone, M; Mezzasoma, AM; Momi, S; Page, CP; Paul, W | 1 |
| Cayatte, AJ; Cohen, RA; Du, Y; Lavielle, G; Oliver-Krasinski, J; Verbeuren, TJ | 1 |
| Ghofrani, HA; Grimminger, F; Hardebusch, T; Schermuly, RT; Seeger, W; Tadic, A; Voswinckel, R; Weissmann, N | 1 |
| Andrioli, G; Bellavite, P; Lussignoli, S; Minuz, P; Ortolani, R; Pincelli, S; Solero, P | 1 |
| Cameron, KE; Heptinstall, S; May, JA; Sanderson, HM; Storey, RF; White, AE | 1 |
| Casonato, A; Deana, R; Francesconi, M; Girolami, A; Scapin, M | 1 |
| Gresele, P; Mezzasoma, AM; Venditti, G; Vezza, R | 1 |
| Aznar, J; Broekman, MJ; Marcus, AJ; Martínez, M; Moscardó, A; Piñón, M; Santos, MT; Vallés, J | 1 |
| Lund, T; Østerud, B | 1 |
| Jin, JL; Lee, S; Lee, YY; Yun-Choi, HS | 1 |
| Craddock-Royal, BD; Maayani, S; Patel, ND; Schwarz, TE; Tagliente, TM | 1 |
| Bose, R; McNicol, A; Roberts, DE | 1 |
| Bolla, M; Habib, A; Henrion, D; Levy, BI; Levy-Toledano, S; Loufrani, L; You, D | 1 |
| Akkayagil, E; Fink, L; Ghofrani, HA; Grimminger, F; Hänze, J; Quanz, K; Rose, F; Schermuly, RT; Seeger, W; Weissmann, N | 1 |
| Aktas, B; Eckes, B; Grüner, S; Krieg, T; Moers, A; Nieswandt, B; Offermanns, S; Prostredna, M; Schulte, V | 1 |
| Covic, L; Kuliopulos, A; Mohanlal, R | 1 |
| Buchspies, D; Fink, L; Gassmann, M; Ghofrani, HA; Grimminger, F; Keller, S; Manz, D; Mehling, T; Quanz, K; Schermuly, RT; Seeger, W; Voswinckel, R; Weissmann, N | 1 |
| Cosemans, JM; Eckes, B; Heemskerk, JW; Kuijpers, MJ; Munnix, IC; Nieswandt, B; Pozgajova, M | 1 |
| Fox, SC; Heptinstall, S; White, AE; Wilcox, RG; Xavier, RG | 1 |
| Harrington, LS; Lucas, R; McMaster, SK; Mitchell, JA; Moreno, L; Scadding, G; Warner, TD | 1 |
| Jin, J; Kim, JM; Koo, YK; Lee, YY; Park, S; Yun-Choi, HS | 1 |
| Adachi, S; Akamatsu, S; Doi, T; Enomoto, Y; Iwama, T; Kozawa, O; Matsushima-Nishiwaki, R; Niwa, M; Ogura, S; Tokuda, H; Yoshimura, S | 1 |
| Beckerman, J; Myers, A; Vicini, S; Young, JP | 1 |
| Armstrong, PC; Chan, MV; Jakubowski, JA; Kirkby, NS; Leadbeater, PD; Mitchell, JA; Warner, TD | 1 |
| Böhm, A; Daum, G; Geisslinger, G; Hohlfeld, T; Nüsing, RM; Polzin, A; Rauch, BH; Schrör, K; Ulrych, T | 1 |
| Cherdon, C; de Leval, L; Defraigne, JO; Dogné, JM; Drion, P; Hanson, J; Masereel, B; Michiels, C; Ooms, A; Pirotte, B; Rolin, S; Sakalihassan, N | 1 |
| Armstrong, PC; Emerson, M; Kirkby, NS; Mitchell, JA; Warner, TD; Zain, ZN | 1 |
| Hsu, MT; Huang, SW; Huang, TF; Kuo, HL; Kuo, SC; Lien, JC; Lin, SW; Peng, HC; Tseng, YJ | 1 |
| Boeglin, WE; Boutaud, O; Giménez-Bastida, JA; Malkowski, MG; Schneider, C | 1 |
| Blaha, V; Carazo, A; Hrubša, M; Javorská, L; Karlíčková, J; Konečný, L; Krčmová, LK; Matoušová, K; Mladěnka, P; Musil, F; Paclíková, M; Parvin, MS; Skořepa, P; Šmahelová, A | 1 |
1 review(s) available for aspirin and 15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid
| Article | Year |
|---|---|
Sex-Related Differences in Platelet Aggregation: A Literature Review Supplemented with Local Data from a Group of Generally Healthy Individuals.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Female; Humans; Lactones; Male; Platelet Aggregation; Platelet Aggregation Inhibitors | 2023 |
2 trial(s) available for aspirin and 15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid
| Article | Year |
|---|---|
Thromboxane receptor blockade versus cyclooxigenase inhibition: antiplatelet effects in patients.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angioplasty, Balloon; Arteriosclerosis; Aspirin; Bleeding Time; Blood Platelets; Clinical Trials as Topic; Collagen; Cyclooxygenase Inhibitors; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxane B2; Thromboxanes | 1986 |
Ex vivo response to aspirin differs in stroke patients with single or recurrent events: a pilot study.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aged; Aspirin; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Pilot Projects; Platelet Aggregation; Prospective Studies; Recurrence; Stroke | 1999 |
68 other study(ies) available for aspirin and 15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid
| Article | Year |
|---|---|
9, 11-Azo-12-oxa-15-hydroxyprostanoic acid: a potent thromboxane synthetase inhibitor and a PGH2/TxA2 receptor antagonist.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Humans; Microsomes; Oxidoreductases; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Cell Surface; Receptors, Prostaglandin; Swine; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes | 1979 |
Sexual dimorphism in blood pressure response to thromboxane agonist U 46619 and to endothelin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Blood Pressure; Endothelins; Female; Male; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Sex Characteristics; Vasoconstrictor Agents | 1992 |
Effects of combination therapy with low-dose aspirin and warfarin on platelet functions after heart valve replacement.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Bleeding Time; Blood Platelets; Calcium; Collagen; Drug Therapy, Combination; Female; Heart Valve Prosthesis; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prostaglandin Endoperoxides, Synthetic; Thromboembolism; Ticlopidine; Warfarin | 1991 |
Protective effects of the novel thromboxane A2 receptor antagonist sodium (E)-11-[2-(5,6-dimethyl-1-benzimidazolyl)-ethylidene]-6,11- dihydrodibenz[b,e]oxepine-2-carboxylate monohydrate against 9,11-dideoxy- 9 alpha, 11 alpha-epoxymethano-prostaglandin F2
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Benzimidazoles; Benzoxepins; Blood Pressure; Death, Sudden; Dose-Response Relationship, Drug; Guinea Pigs; Male; Phenylacetates; Platelet Aggregation Inhibitors; Platelet Count; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Sulfonamides; Thromboxane A2; Thromboxanes; Ticlopidine | 1991 |
Human vascular smooth muscle cells inhibit platelet aggregation when incubated with glyceryl trinitrate: evidence for generation of nitric oxide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Cells, Cultured; Hemoglobins; Humans; In Vitro Techniques; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Nitroglycerin; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic | 1991 |
Arachidonic acid-induced calcium influx in human platelets. Comparison with the effect of thrombin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Biological Transport; Blood Platelets; Calcium; Carcinoma, Ehrlich Tumor; Egtazic Acid; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Fluoresceins; Fluorescent Dyes; Fura-2; Humans; In Vitro Techniques; Kinetics; Manganese; Masoprocol; Mice; Neutrophils; Prostaglandin Endoperoxides, Synthetic; Rats; Spectrometry, Fluorescence; Structure-Activity Relationship; T-Lymphocytes; Thrombin | 1990 |
The effects of siguazodan, a selective phosphodiesterase inhibitor, on human platelet function.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Blood Platelets; Calcium; Chromatography, Ion Exchange; Collagen; Cyclic AMP; Guanidines; Humans; In Vitro Techniques; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandin Endoperoxides, Synthetic; Pyridazines | 1990 |
High concentrations of exogenous arachidonate inhibit calcium mobilization in platelets by stimulation of adenylate cyclase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenylyl Cyclases; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcium; Cyclic AMP; Deoxyadenosines; Dideoxyadenosine; Enzyme Induction; Epoprostenol; Humans; Iloprost; In Vitro Techniques; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Pyrazoles; Thromboxane B2 | 1988 |
The PGI2-analogue iloprost and the TXA2-receptor antagonist sulotroban synergistically inhibit TXA2-dependent platelet activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Drug Synergism; Epoprostenol; Fatty Acids, Unsaturated; Humans; Hydrazines; Iloprost; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Prostaglandins, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides | 1988 |
Thromboxane is produced in response to intracoronary infusions of complement C5a in pigs. Cyclooxygenase blockade does not reduce the myocardial ischemia and leukocyte accumulation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Complement C5a; Coronary Disease; Coronary Vessels; Cyclooxygenase Inhibitors; Female; Indomethacin; Injections, Intra-Arterial; Leukocyte Count; Leukocytes; Male; Myocardium; Prostaglandin Endoperoxides, Synthetic; Swine; Thromboxane B2; Thromboxanes | 1989 |
Effects of ethanol on human platelets stimulated with platelet-activating factor, a biologically active ether phospholipid.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Blood Platelets; Ethanol; Humans; In Vitro Techniques; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides, Synthetic; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Prostaglandin; Receptors, Thromboxane; Serotonin; Thromboxane A2 | 1989 |
Occurrence of the 15-hydroxy derivative of dihomogammalinolenic acid in human platelets and its biological effect.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Aspirin; Blood Platelets; Drug Synergism; Fatty Acids, Unsaturated; Humans; Hydroxylation; Kinetics; Leukotriene B4; Linolenic Acids; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic | 1988 |
Platelets, eicosanoids, and coronary vasospasm.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cattle; Coronary Vasospasm; Coronary Vessels; Eicosanoic Acids; Humans; In Vitro Techniques; Methysergide; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Salicylates; Salicylic Acid; Vasoconstriction | 1987 |
Response of human platelets exposed to arachidonate upon stimulation with other agonists: possible role of Ca2+i movement.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Biological Transport; Blood Platelets; Calcium; Humans; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thrombin | 1987 |
Effects of the prostaglandin H2/thromboxane A2 antagonist BM 13.177 on human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Blood Platelets; Collagen; Humans; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Serotonin; Sulfonamides; Thrombin; Thromboxane A2; Thromboxanes | 1985 |
Effects of trapidil and trapidil derivatives on arachidonic acid and prostaglandin endoperoxide analogue U 46619-induced blood pressure changes in rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 6-Ketoprostaglandin F1 alpha; Animals; Antihypertensive Agents; Aspirin; Blood Pressure; Calcium Channel Blockers; Male; Prostaglandin Endoperoxides, Synthetic; Pyrimidines; Rats; Rats, Inbred Strains; Reference Values; Thromboxane B2; Trapidil | 1988 |
Prostaglandins and human platelet aggregation. Implications for the anti-aggregating activity of thromboxane-synthase inhibitors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Dinoprost; Dinoprostone; Drug Synergism; Humans; Imidazoles; Oxidoreductases; Platelet Aggregation; Prostaglandin D2; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Prostaglandins D; Prostaglandins E; Prostaglandins F; Prostanoic Acids; Thromboxane B2; Thromboxane-A Synthase | 1985 |
Effects of any epoxymethano stable analogue of prostaglandin endoperoxides (U-46619) on human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Blood Platelets; Calcium; Cyclic AMP; Fibrinogen; Humans; L-Lactate Dehydrogenase; Magnesium; Malondialdehyde; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Serotonin; Thromboxane B2 | 1981 |
The role of ADP secretion and thromboxane synthesis in factor VIII binding to platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Factor VIII; Humans; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxane A2; Thromboxanes | 1983 |
Suppression of lymphatic vessel contractility with inhibitors of arachidonic acid metabolism.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cattle; Dinoprost; Indomethacin; Lymphatic System; Muscle Contraction; Prostaglandin Endoperoxides, Synthetic; Prostaglandins F; SRS-A | 1983 |
[Thrombocyte interaction with a collagen substrate: the role of thrombocyte-synthesized prostaglandin endoperoxides and thromboxane A2].
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Humans; Microscopy, Electron, Scanning; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Thrombosis; Thromboxane A2; Thromboxanes | 1984 |
Platelet prostanoids in interaction of platelets with collagen substrates. II. Effects of exogenous arachidonic acid, stable PG endoperoxides analogue, and aspirin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cattle; Collagen; Humans; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxanes | 1984 |
Total and selective desensitisation of human platelets to synthetic platelet activating factor (PAF): evidence that extracellular PAF does not mediate collagen-induced aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Extracellular Space; Humans; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic | 1983 |
Arachidonic acid induces human platelet-fibrin retraction: the role of platelet cyclic endoperoxides.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alprostadil; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Clot Retraction; Epoprostenol; Fatty Acids, Unsaturated; Fibrin; Humans; Imidazoles; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins D; Prostaglandins E; Prostaglandins H; Prostaglandins, Synthetic; Thromboxane B2 | 1982 |
Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Anti-Inflammatory Agents; Aspirin; Coronary Vessels; Corticosterone; Diabetes Mellitus, Experimental; Dogs; Dose-Response Relationship, Drug; Epoprostenol; Imidazoles; Indoles; Indomethacin; Kinetics; Pancreatectomy; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Pyridines | 1981 |
A method for quantitating platelet aggregation and analyzing drug-receptor interactions on platelets in whole blood in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Aspirin; Blood Cell Count; Blood Platelets; Epinephrine; Guinea Pigs; In Vitro Techniques; Phentolamine; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Receptors, Drug; Time Factors | 1981 |
Effect of picotamide on the calcium mobilization and phospholipase C activation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Chromatography, Gel; Enzyme Activation; Humans; In Vitro Techniques; Phthalic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptors, Thromboxane; Thrombin; Thromboxane A2; Type C Phospholipases | 1994 |
U 46619 induces different blood pressure effects in male and female spontaneously hypertensive rats (SHR).
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Administration, Oral; Animals; Aorta; Aspirin; Blood Pressure; Drug Synergism; Female; Injections, Intravenous; Male; Prostaglandin Endoperoxides, Synthetic; Prostaglandins F; Rats; Rats, Inbred SHR; Thromboxane B2; Vasoconstrictor Agents | 1993 |
A ferret model of electrical-induction of arterial thrombosis that is sensitive to aspirin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Carotid Arteries; Carotid Artery Injuries; Collagen; Disease Models, Animal; Electric Stimulation; Ferrets; Fibrin; Humans; In Vitro Techniques; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Oxazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Prothrombin Time; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Species Specificity; Thrombosis; Thromboxane A2; Vasoconstrictor Agents | 1996 |
Platelet reactivity in vitro in relation to thromboxane in healthy pregnancy.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adolescent; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cross-Sectional Studies; Cyclic AMP; Dioxanes; Female; Humans; Imidazoles; Platelet Aggregation; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Thromboxane-A Synthase | 1996 |
Mechanism of the contractile effect of diaspirin-cross-linked hemoglobin in rat isolated aorta strip denuded of endothelium as revealed using an oil-immersion procedure.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antioxidants; Aorta, Thoracic; Arachidonic Acid; Aspirin; Blood Substitutes; Cytological Techniques; Endothelium, Vascular; Hemoglobins; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Sprague-Dawley; Thromboxane A2; Vasoconstrictor Agents | 1996 |
Characteristics of protein kinase C-independent exocytosis in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Blood Platelets; Exocytosis; Humans; Indoles; Maleimides; Molecular Weight; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Thromboxane B2; Vasoconstrictor Agents | 1997 |
The Ca2+-mobilizing potency of alpha-thrombin and thrombin-receptor-activating peptide on human platelets -- concentration and time effects of thrombin-induced Ca2+ signaling.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Apyrase; Aspirin; Blood Platelets; Calcium; Cytosol; Egtazic Acid; Humans; In Vitro Techniques; Kinetics; Peptide Fragments; Platelet Activation; Receptors, Thrombin; Signal Transduction; Thrombin; Time Factors | 1997 |
Inhibitory actions of ONO-3708 on the stretch-induced contraction potentiated by hemolysate/oxyhemoglobin studied in dog cerebral artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Cerebral Arteries; Cyclooxygenase Inhibitors; Dinoprost; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Female; Male; Methacrylates; Muscle Contraction; Muscle, Smooth, Vascular; Oxyhemoglobins; Oxytocics; Reflex, Stretch; Thromboxane A2; Thromboxane-A Synthase; Vasoconstrictor Agents | 1997 |
Hemoglobin A0 and alpha-crosslinked hemoglobin (alpha-DBBF) potentiate agonist-induced platelet aggregation through the platelet thromboxane receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Aspirin; Blood Platelets; Blood Substitutes; Collagen; Drug Synergism; Heme; Hemoglobin A; Humans; Membrane Proteins; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Second Messenger Systems; Thrombin | 1998 |
Inhibition of platelet-vessel wall interactions by thromboxane receptor antagonism in a human in vitro system: potentiation of antiplatelet effects of aspirin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Aspirin; Blood Platelets; Carbazoles; Drug Synergism; Endothelium, Vascular; Humans; In Vitro Techniques; Perfusion; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thromboxane; Sulfonamides | 1998 |
Influence of low- and high-dose aspirin treatment on thrombin generation in whole blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Area Under Curve; Aspirin; Collagen; Dose-Response Relationship, Drug; Female; Humans; Iloprost; Immunoenzyme Techniques; Male; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Statistics, Nonparametric; Thrombin; Vasoconstrictor Agents | 1998 |
Inhibitory effect of sulfur-containing compounds in Scorodocarpus borneensis Becc. on the aggregation of rabbit platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Coagulation Factors; Collagen; Hemostatics; Hexanes; Inhibitory Concentration 50; Octanes; Plant Extracts; Plants, Edible; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Sulfur Compounds; Thrombin; Trees; Vasoconstrictor Agents | 1999 |
The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Blood Platelets; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Platelet Activation; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2Y1; Signal Transduction; Thromboxane A2; Vasoconstrictor Agents | 2000 |
Prevention of pulmonary thromboembolism by NCX 4016, a nitric oxide-releasing aspirin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Lung; Male; Mice; Nitroarginine; Platelet Aggregation Inhibitors; Platelet Count; Pulmonary Artery; Pulmonary Embolism; Rabbits; Thrombin; Thrombosis | 2000 |
The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice: evidence that eicosanoids other than thromboxane contribute to atherosclerosis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Aspirin; Body Weight; Cell Adhesion; Cholesterol; Endothelium, Vascular; Female; Humans; Intercellular Adhesion Molecule-1; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Naphthalenes; Platelet Aggregation Inhibitors; Propionates; Receptors, Thromboxane; Tetrahydronaphthalenes; Thromboxane A2; Thromboxane B2; U937 Cells; Umbilical Veins; Vasoconstrictor Agents | 2000 |
Nitric oxide (NO)-dependent but not NO-independent guanylate cyclase activation attenuates hypoxic vasoconstriction in rabbit lungs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aminoquinolines; Animals; Aspirin; Blood Pressure; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Female; Guanylate Cyclase; Hypoxia; In Vitro Techniques; Lung; Male; Methylene Blue; Nitric Oxide; omega-N-Methylarginine; Pulmonary Artery; Purinones; Rabbits; Vasoconstriction; Vasoconstrictor Agents | 2000 |
Defective platelet response to arachidonic acid and thromboxane A(2) in subjects with Pl(A2) polymorphism of beta(3) subunit (glycoprotein IIIa).
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; beta-Thromboglobulin; Blood Platelets; Coronary Disease; Female; Flow Cytometry; Genotype; Humans; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Risk Factors; Statistics, Nonparametric; Thrombin; Thromboxane A2 | 2000 |
The central role of the P(2T) receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Analysis of Variance; Annexin A5; Aspirin; Blood Platelets; Calcium; Collagen; Cytosol; Fibrinolytic Agents; Flow Cytometry; Humans; Membrane Proteins; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Serotonin; Stimulation, Chemical; Thromboxane A2 | 2000 |
Adrenaline potentiates type 2B von Willebrand factor-induced activation of human platelets by enhancing both the formation and action of thromboxanes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Antagonists; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Drug Synergism; Epinephrine; Humans; Kinetics; Lipoxygenase; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Prostanoic Acids; Serotonin; Sympathomimetics; Thromboxanes; Tyrosine; Vasoconstrictor Agents; von Willebrand Factor; Yohimbine | 2000 |
Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Biphenyl Compounds; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Cells, Cultured; Enzyme Inhibitors; Fatty Acids, Unsaturated; Heptanoic Acids; Humans; Hydrazines; Imidazoles; Inositol Phosphates; Kidney; Methacrylates; Phenylacetates; Platelet Activating Factor; Platelet Activation; Prostaglandin H2; Prostaglandins H; Protein Isoforms; Receptors, Thromboxane; Recombinant Fusion Proteins; Sulfonamides; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 2002 |
Platelet-erythrocyte interactions enhance alpha(IIb)beta(3) integrin receptor activation and P-selectin expression during platelet recruitment: down-regulation by aspirin ex vivo.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Cytosol; Erythrocytes; Humans; In Vitro Techniques; Ionomycin; P-Selectin; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Vasoconstrictor Agents | 2002 |
The promoting effect of epinephrine on lipopolysaccharide-induced interleukin-8 production in whole blood may be mediated by thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; Fatty Acids, Unsaturated; Humans; Hydrazines; Interleukin-8; Lipopolysaccharides; Receptors, Thromboxane; Thromboxane A2; Tumor Necrosis Factor-alpha | 2003 |
Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angelica; Animals; Arachidonic Acid; Aspirin; Benzopyrans; Blood Platelets; Butyrates; Collagen; Coumarins; Furocoumarins; Glucosides; Herbal Medicine; Heterocyclic Compounds, 3-Ring; Korea; Male; Medicine, East Asian Traditional; Methanol; Nephelometry and Turbidimetry; Plant Extracts; Plant Roots; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley | 2003 |
Diversity of signaling underlying responses mediated by selective activation of the platelet thromboxane A2 (TXA2) receptor; pharmacological and kinetic studies in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Androstadienes; Aspirin; Blood Platelets; Cell Size; Epinephrine; Humans; Kinetics; Platelet Activation; Platelet Aggregation; Receptors, Thromboxane A2, Prostaglandin H2; Reference Values; Wortmannin | 2003 |
Mechanism of collagen activation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Benzofurans; Blood Platelets; Calcium; Collagen; Dose-Response Relationship, Drug; Egtazic Acid; Ethers, Cyclic; Fluoresceins; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Imidazoles; Inositol 1,4,5-Trisphosphate; Models, Biological; Organic Chemicals; Platelet Activation; Platelet Aggregation; Sodium; Sodium-Calcium Exchanger; Specimen Handling; Temperature; Thromboxane A2; Time Factors; Vasoconstrictor Agents | 2004 |
Cyclooxygenase involvement in thromboxane-dependent contraction in rat mesenteric resistance arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Endothelin-1; Fatty Acids, Unsaturated; Flurbiprofen; Hydrazines; Indomethacin; Isoenzymes; Male; Membrane Proteins; Mesenteric Arteries; Organic Chemicals; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred WKY; Receptors, Thromboxane A2, Prostaglandin H2; Sulfonamides; Thromboxane A2; Vascular Resistance; Vasoconstriction | 2004 |
Basic features of hypoxic pulmonary vasoconstriction in mice.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amylopectin; Animals; Aspirin; Blood Pressure; Drug Interactions; Enzyme Inhibitors; Hypoxia; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; omega-N-Methylarginine; Oxygen; Pulmonary Artery; Pulmonary Circulation; Pulmonary Gas Exchange; Species Specificity; Tidal Volume; Vasoconstriction; Vasoconstrictor Agents | 2004 |
Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antibodies, Monoclonal; Aspirin; Bleeding Time; Collagen; Drug Evaluation, Preclinical; Drug Synergism; Fibrinolytic Agents; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gq-G11; Hemorrhage; Hemostasis; Integrin alpha2beta1; Mice; Mice, Knockout; Platelet Activation; Platelet Adhesiveness; Platelet Membrane Glycoproteins; Receptors, Thromboxane A2, Prostaglandin H2; Signal Transduction; Thrombosis | 2004 |
Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anti-Inflammatory Agents, Non-Steroidal; Apyrase; Aspirin; Blood Platelets; Calcium; Chromatography, Gel; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heparin; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Protein Isoforms; Time Factors | 2004 |
Congenital erythropoietin over-expression causes "anti-pulmonary hypertensive" structural and functional changes in mice, both in normoxia and hypoxia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Blood Pressure; Blood Vessels; Blood Viscosity; Cyclooxygenase Inhibitors; Erythropoietin; Hematocrit; Hypertension, Pulmonary; Hypertrophy, Left Ventricular; Hypertrophy, Right Ventricular; Hypoxia; Lung; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Smooth, Vascular; Nitric Oxide Synthase; omega-N-Methylarginine; Up-Regulation; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents | 2005 |
Role of murine integrin alpha2beta1 in thrombus stabilization and embolization: contribution of thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Chlorides; Collagen; Ferric Compounds; Integrin alpha2beta1; Mice; Mice, Knockout; Thromboembolism; Thrombosis; Thromboxane A2 | 2007 |
Enhanced platelet aggregation and activation under conditions of hypothermia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Anticoagulants; Antigens, CD; Aspirin; Blood Platelets; Blood Specimen Collection; Citrates; Cold Temperature; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Hirudins; Humans; Hypothermia, Induced; In Vitro Techniques; P-Selectin; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Platelet Membrane Glycoproteins; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Receptors, Thrombin; Tetraspanin 30; Time Factors | 2007 |
COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aspirin; Asthma; Bronchi; Bronchoconstriction; Bronchoconstrictor Agents; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Hypersensitivity; Humans; Lactones; Membrane Proteins; Mice; Mice, Knockout; Respiratory Mucosa; Sulfones; Vasoconstrictor Agents | 2008 |
Augmentation of U46619 induced human platelet aggregation by aspirin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Adult; Aspirin; Blood Platelets; Cyclic AMP; Cyclooxygenase Inhibitors; Female; Humans; Male; Nitric Oxide Synthase; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Vasoconstrictor Agents; Young Adult | 2009 |
Thromboxane A(2) promotes soluble CD40 ligand release from human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aged; Aspirin; Atherosclerosis; Blood Platelets; Carotid Artery Diseases; CD40 Ligand; Female; Humans; Male; MAP Kinase Kinase 4; Methacrylates; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrazoles; Ristocetin; Thromboxane A2 | 2010 |
Acetylsalicylic acid enhances purinergic receptor-mediated outward currents in rat megakaryocytes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aspirin; Calcium; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Fibrinolytic Agents; Ionophores; Kinetics; Male; Megakaryocytes; Membrane Potentials; Nystatin; Patch-Clamp Techniques; Platelet Aggregation Inhibitors; Potassium; Potassium Channels, Calcium-Activated; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Purinergic; Receptors, Thromboxane; Signal Transduction; Thionucleotides | 2010 |
In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Aspirin; Collagen; Drug Synergism; Epinephrine; Humans; In Vitro Techniques; Peptide Fragments; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thromboxane A2 | 2011 |
Release of sphingosine-1-phosphate from human platelets is dependent on thromboxane formation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aspirin; Blood Platelets; Cells, Cultured; Chromatography, Thin Layer; Humans; Lysophospholipids; Receptors, Thromboxane; Sphingosine; Thrombin; Thromboxanes | 2011 |
BM-573 inhibits the development of early atherosclerotic lesions in Apo E deficient mice by blocking TP receptors and thromboxane synthase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apolipoproteins E; Aspirin; Atherosclerosis; Dinoprost; Drug Therapy, Combination; Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Mice; Mice, Knockout; Receptors, Thromboxane; Saphenous Vein; Sulfonylurea Compounds; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase; Vascular Cell Adhesion Molecule-1 | 2011 |
Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Collagen; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Isoxazoles; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Thrombosis | 2011 |
A novel thromboxane receptor antagonist, nstpbp5185, inhibits platelet aggregation and thrombus formation in animal models.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arachidonic Acid; Aspirin; Benzimidazoles; Blood Platelets; Calcium; Collagen; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Microvessels; P-Selectin; Platelet Aggregation; Pulmonary Embolism; Receptors, Thromboxane A2, Prostaglandin H2; Thrombosis; Thromboxane A2 | 2016 |
Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylation; Aspirin; Cells, Cultured; Chromatography, Liquid; Cyclooxygenase 2; Dinoprostone; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Leukocytes; Mass Spectrometry; Platelet Aggregation | 2019 |