Compounds > aspergillomarasmine a
Page last updated: 2024-09-05

aspergillomarasmine a and aspartic acid

aspergillomarasmine a has been researched along with aspartic acid in 14 studies

Compound Research Comparison

Studies
(aspergillomarasmine a)		Trials
(aspergillomarasmine a)		Recent Studies (post-2010)
(aspergillomarasmine a)		Studies
(aspartic acid)		Trials
(aspartic acid)		Recent Studies (post-2010) (aspartic acid)
1701523,0054174,018

Protein Interaction Comparison

ProteinTaxonomyaspergillomarasmine a (IC50)aspartic acid (IC50)
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)1.638
Excitatory amino acid transporter 1Homo sapiens (human)90.1265
Excitatory amino acid transporter 2Homo sapiens (human)11
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)1.638
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)1.638
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)1.638
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)1.638
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)1.638
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)1.638

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (14.29)18.2507
2000's0 (0.00)29.6817
2010's9 (64.29)24.3611
2020's3 (21.43)2.80

Authors

AuthorsStudies
Friis, P; Møller, BL; Olsen, CE1
Arai, K; Asakura, R; Ashikawa, N; Ashizawa, N; Kobayashi, F; Matsuura, A; Okumura, H; Takahashi, M1
Courvalin, P; Meziane-Cherif, D1
Coombes, BK; De Pascale, G; King, AM; King, DT; Reid-Yu, SA; Strynadka, NC; Walsh, TR; Wang, W; Wright, GD1
Hong, B; Lei, X; Liao, D; Wang, J; Wu, F; Yang, S; Zhang, J1
Capretta, A; King, AM; Koteva, K; Wright, GD1
Al-Karmi, S; Albu, SA; Capretta, A; King, AM; Koteva, K; Wright, GD1
Dolgin, E1
Bai, Y; Guo, Q; Lei, X; Song, F; Wang, S; Wei, Q; Yang, S; Zhang, J; Zhang, L1
Adkins, Z; Aitha, M; Bergstrom, A; Bonomo, RA; Brodbelt, JS; Burnett, M; Cheng, Z; Crowder, MW; Fast, W; Hill, J; Katko, A; Martin, NI; Mehaffey, MR; Page, RC; Tehrani, KHME; Tierney, DL; Wright, GD; Yang, H1
Bai, Y; Guo, Q; Lei, X; Wang, S; Zhang, J; Zhou, J1
Brüchle, NC; Fu, H; Martin, NI; Mashayekhi, V; Poelarends, GJ; Prats Luján, A; Tehrani, KHME; van Haren, MJ1
Amatuni, A; Li, J; Renata, H1
Martin, NI; Rotondo, CM; Sychantha, D; Tehrani, KHME; Wright, GD1

Reviews

1 review(s) available for aspergillomarasmine a and aspartic acid

ArticleYear
Recent advances in the chemoenzymatic synthesis of bioactive natural products.
    Current opinion in chemical biology, 2020, Volume: 55

    Topics: Aspartic Acid; Biocatalysis; Biological Products; Enzymes; Isoquinolines; Kainic Acid; Molecular Conformation; Podophyllotoxin; Quinolines; Quinolones; Stereoisomerism

2020

Other Studies

13 other study(ies) available for aspergillomarasmine a and aspartic acid

ArticleYear
Toxin production in Pyrenophora teres, the ascomycete causing the net-spot blotch disease of barley (Hordeum vulgare L.).
    The Journal of biological chemistry, 1991, Jul-15, Volume: 266, Issue:20

    Topics: Ascomycota; Aspartic Acid; Hordeum; Molecular Structure; Mycotoxins; Plant Diseases

1991
Pharmacological profiles of aspergillomarasmines as endothelin converting enzyme inhibitors.
    Japanese journal of pharmacology, 1993, Volume: 63, Issue:2

    Topics: Animals; Aorta; Aspartic Acid; Aspartic Acid Endopeptidases; Cattle; Edetic Acid; Endothelin-Converting Enzymes; Endothelins; Endothelium, Vascular; Glycopeptides; Hypertension; In Vitro Techniques; Lethal Dose 50; Male; Metalloendopeptidases; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley

1993
Antibiotic resistance: to the rescue of old drugs.
    Nature, 2014, Jun-26, Volume: 510, Issue:7506

    Topics: Animals; Aspartic Acid; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Carbapenems; Female; Gram-Negative Bacteria; Meropenem; Thienamycins

2014
Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance.
    Nature, 2014, Jun-26, Volume: 510, Issue:7506

    Topics: Animals; Anti-Bacterial Agents; Aspartic Acid; Aspergillus; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Biological Products; Carbapenems; Drug Evaluation, Preclinical; Drug Synergism; Female; Gram-Negative Bacteria; Klebsiella pneumoniae; Meropenem; Mice; Thienamycins

2014
Total Synthesis and Structural Reassignment of Aspergillomarasmine A.
    Angewandte Chemie (International ed. in English), 2016, Mar-18, Volume: 55, Issue:13

    Topics: Aspartic Acid; Humans; Molecular Structure

2016
Total Synthesis and Activity of the Metallo-β-lactamase Inhibitor Aspergillomarasmine A.
    Angewandte Chemie (International ed. in English), 2016, Feb-05, Volume: 55, Issue:6

    Topics: Aspartic Acid; Aspergillus; beta-Lactamase Inhibitors; beta-Lactamases; Dose-Response Relationship, Drug; Molecular Structure; Structure-Activity Relationship

2016
Total Synthesis of Aspergillomarasmine A and Related Compounds: A Sulfamidate Approach Enables Exploration of Structure-Activity Relationships.
    Angewandte Chemie (International ed. in English), 2016, 10-10, Volume: 55, Issue:42

    Topics: Acinetobacter; Amides; Anti-Bacterial Agents; Aspartic Acid; beta-Lactamases; Dose-Response Relationship, Drug; Enterobacteriaceae; Enzyme Inhibitors; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas; Structure-Activity Relationship

2016
Inner Workings: Combating antibiotic resistance from the ground up.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, 10-18, Volume: 113, Issue:42

    Topics: Anti-Bacterial Agents; Aspartic Acid; Aspergillus; Drug Resistance, Microbial; Humans; Microbial Sensitivity Tests; Mycotoxins; Soil Microbiology

2016
Synthesis and biological evaluation of Aspergillomarasmine A derivatives as novel NDM-1 inhibitor to overcome antibiotics resistance.
    Bioorganic & medicinal chemistry, 2017, 10-01, Volume: 25, Issue:19

    Topics: Aspartic Acid; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Humans; Klebsiella Infections; Klebsiella pneumoniae

2017
Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7.
    ACS infectious diseases, 2018, 02-09, Volume: 4, Issue:2

    Topics: Aspartic Acid; beta-Lactamase Inhibitors; beta-Lactamases; Biological Products; Cobalt; Enzyme Activation; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Protein Binding; Quantitative Structure-Activity Relationship; Zinc

2018
Total Syntheses of Natural Metallophores Staphylopine and Aspergillomarasmine A.
    The Journal of organic chemistry, 2017, 12-15, Volume: 82, Issue:24

    Topics: Aspartic Acid; Imidazoles; Molecular Structure

2017
Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine-N,N'-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1.
    Chemical communications (Cambridge, England), 2020, Mar-10, Volume: 56, Issue:20

    Topics: Amino Acids; Aspartic Acid; beta-Lactamase Inhibitors; beta-Lactamases; Coordination Complexes; Dose-Response Relationship, Drug; Escherichia coli Proteins; Ethylenediamines; Molecular Structure; Structure-Activity Relationship; Succinates; Zinc

2020
Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn
    The Journal of biological chemistry, 2021, Volume: 297, Issue:2

    Topics: Anti-Bacterial Agents; Aspartic Acid; Bacteria; beta-Lactamase Inhibitors; beta-Lactamases; Chelating Agents; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Zinc

2021