aspergillide-a and fludarabine
aspergillide-a has been researched along with fludarabine* in 1 studies
Other Studies
1 other study(ies) available for aspergillide-a and fludarabine
Article | Year |
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Synthesis and biological properties of the cytotoxic 14-membered macrolides aspergillide A and B.
Total, stereoselective syntheses of the naturally occurring, cytotoxic macrolides aspergillide A and B are described. Olefin metatheses and asymmetric allylations were key steps in the synthetic sequences. Cytotoxicity assays against several tumor cell lines have been performed for the two aspergillides and some of the intermediates or side products of the synthetic sequence. One of these intermediates has been found markedly active against the human leukemia cancer cell line HL-60, with an IC(50) value comparable with that of the clinical drug fludarabine. Topics: Antineoplastic Agents; Aspergillus; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Inhibitory Concentration 50; Macrolides; Marine Biology; Molecular Structure; Stereoisomerism; Vidarabine | 2011 |