asperazine and indoline

asperazine has been researched along with indoline* in 1 studies

Other Studies

1 other study(ies) available for asperazine and indoline

ArticleYear
Copper-Mediated Single-Electron Approach to Indoline Amination: Scope, Mechanism, and Total Synthesis of Asperazine A.
    The Journal of organic chemistry, 2022, 08-05, Volume: 87, Issue:15

    Pyrroloindolines bearing a C3-N linkage comprise the core of many biologically active natural products, but many methods toward their synthesis are limited by the sterics or electronics of the product. We report a single electron-based approach for the synthesis of this scaffold and demonstrate high-yielding aminations, regardless of electronic or steric demands. The transformation uses copper wire and isopropanol to promote the reaction. The broad synthetic utility of this heterogeneous copper-catalyzed approach to access pyrroloindolines, diketopiperazine, furoindoline, and (+)-asperazine is included, along with experiments to provide insight into the mechanism of this new process.

    Topics: Amination; Catalysis; Copper; Diketopiperazines; Electrons; Indoles; Piperazines

2022