Page last updated: 2024-09-05

aspartimide and aspartic acid

aspartimide has been researched along with aspartic acid in 38 studies

Compound Research Comparison

Studies (aspartimide)	Trials (aspartimide)	Recent Studies (post-2010) (aspartimide)	Studies (aspartic acid)	Trials (aspartic acid)	Recent Studies (post-2010) (aspartic acid)
39	0	16	23,005	417	4,018

Protein Interaction Comparison

Protein	Taxonomy	aspartic acid (IC50)
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	1.638
Excitatory amino acid transporter 1	Homo sapiens (human)	90.1265
Excitatory amino acid transporter 2	Homo sapiens (human)	11
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	1.638
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	1.638
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	1.638
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	1.638
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	1.638
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	1.638

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.63)	18.7374
1990's	4 (10.53)	18.2507
2000's	15 (39.47)	29.6817
2010's	14 (36.84)	24.3611
2020's	4 (10.53)	2.80

Authors

Authors	Studies
Bateman, A; Bennett, HP; Gagnon, C; Toney, K	1
Karlström, A; Undén, A	1
Chen, W; Ede, NJ; Jackson, DC; McCluskey, J; Purcell, AW	1
Cuthbertson, A; Fischer, PM; Husbyn, M; Orning, L	1
Barrow, CJ; Clippingdale, AB; Wade, JD	1
Barrow, CJ; Tickler, AK; Wade, JD	1
Cuthbertson, A; Husbyn, M	1
Dick, F; Mergler, M; Sax, B; Vorherr, T; Weiler, P	1
Dick, F; Mergler, M; Sax, B; Stähelin, C; Vorherr, T	1
BIGNAMI, G; BOVET, D; BOVET-NITTI, F; MISITI, D; ROSNATI, V	1
Cebrián, J; Domingo, V; Reig, F	1
Dziadek, S; Kunz, H; Wagner, M	1
Flora, D; Khan, MA; Mayer, JP; Mo, H; Yan, LZ	1
Dick, F; Mergler, M	1
Kostidis, S; Papas, S; Stathopoulos, P; Tsikaris, V	1
Kaneshiro, CM; Michael, K	1
Collins, JM; Cox, ZJ; Palasek, SA	1
Albericio, F; Alvarez, M; Isidro-Llobet, A; Just-Baringo, X	1
Ilas, J; Schlosser, G; Süli-Vargha, H	1
Lewandowska, B; Mucha, P; Rekowski, P; Ruczyński, J	1
Carlescu, I; Desbrieres, J; Osborn, HM; Popa, M; Scutaru, D	1
Cybal, M; Kocić, I; Konstański, Z; Rekowski, P; Ruczyński, J	1
Albericio, F; El-Faham, A; Subirós-Funosas, R	1
Boos, I; Freund, J; Pöhner, C; Rädisch, M; Schwarzinger, S; Ullmann, V; Unverzagt, C	1
Aussedat, B; Danishefsky, SJ; Vohra, Y; Wang, P	1
Dölling, R; Haberkorn, U; Michels, T; Mier, W	1
Dyer, FB; Garner, P; Joseph, R	1
Chen, CC; Chen, KL; Lin, F; Lin, PC; Liu, XY; Rajagopal, B; Tyan, YC	1
Brandstetter, H; Briza, P; Dall, E; Fegg, JC	1
Behrendt, R; Huber, S; Martí, R; White, P	1
Bathgate, RA; Gooley, PR; Hossain, MA; Petrie, EJ; Sethi, A; Tailhades, J; Wade, JD	1
Behrendt, R; Offer, J; White, P	1
Abdel-Aal, AB; Burlina, F; Offer, J; Papageorgiou, G; Quibell, M; Raz, R	1
Loidl, G; Meier, T; Minuth, M; Rentsch, D; Samson, D	1
Baldauf, S; Bode, JW; Farnung, J; Neumann, K	1
Beiser, M; Cao, L; Elashal, HE; Koos, JD; Link, AJ; Orlova, M; Schröder, HV	1
Cao, L; Elashal, HE; Link, AJ	1
Alam, N; Cao, L; Do, T; Duan, J; Link, AJ; Zhu, A	1

Reviews

1 review(s) available for aspartimide and aspartic acid

Article	Year
Advances in Fmoc solid-phase peptide synthesis. Journal of peptide science : an official publication of the European Peptide Society, 2016, Volume: 22, Issue:1 Topics: Amino Acids; Aspartic Acid; Cell Line; Epithelial Cells; Fluorenes; Glycosylation; Humans; Methylation; Peptides; Phosphorylation; Protein Prenylation; Protein Processing, Post-Translational; Solid-Phase Synthesis Techniques	2016

Other Studies

37 other study(ies) available for aspartimide and aspartic acid

Article	Year
Aspartimide formation in the joining peptide sequence of porcine and mouse pro-opiomelanocortin. The Journal of biological chemistry, 1993, Jan-15, Volume: 268, Issue:2 Topics: Adrenocorticotropic Hormone; Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Cattle; Chromatography, High Pressure Liquid; Endopeptidases; Erythrocytes; Male; Methylation; Mice; Mice, Inbred Strains; Molecular Sequence Data; Peptide Fragments; Pituitary Gland; Pro-Opiomelanocortin; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; Substrate Specificity; Swine	1993
Design of protecting groups for the beta-carboxylic group of aspartic acid that minimize base-catalyzed aspartimide formation. International journal of peptide and protein research, 1996, Volume: 48, Issue:4 Topics: Aspartic Acid; Chromatography, High Pressure Liquid; Esters; Oligopeptides; Piperidines; Temperature; Time Factors	1996
Identification and synthesis of altered peptides modulating T cell recognition of a synthetic peptide antigen. Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity, 1995, Volume: 1, Issue:4 Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cell Line; H-2 Antigens; Indicators and Reagents; Mice; Nitriles; Oligopeptides; T-Lymphocytes, Cytotoxic	1995
Linear analogues derived from the first EGF-like domain of human blood coagulation factor VII: enhanced inhibition of FVIIa/TF complex activity by backbone modification through aspartimide formation. Journal of peptide science : an official publication of the European Peptide Society, 1999, Volume: 5, Issue:7 Topics: Amino Acid Sequence; Aspartic Acid; Chromatography, High Pressure Liquid; Epidermal Growth Factor; Factor VII; Humans; Molecular Sequence Data; Structure-Activity Relationship	1999
Peptide thioester preparation by Fmoc solid phase peptide synthesis for use in native chemical ligation. Journal of peptide science : an official publication of the European Peptide Society, 2000, Volume: 6, Issue:5 Topics: alpha-Synuclein; Amino Acids; Aspartic Acid; Chromatography, High Pressure Liquid; Dimethylformamide; Esters; Fluorenes; Humans; Models, Chemical; Nerve Tissue Proteins; Peptide Biosynthesis; Peptides; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Synucleins; Time Factors; Triazoles	2000
Improved preparation of amyloid-beta peptides using DBU as Nalpha-Fmoc deprotection reagent. Journal of peptide science : an official publication of the European Peptide Society, 2001, Volume: 7, Issue:9 Topics: Amino Acid Sequence; Amino Acids; Amyloid beta-Peptides; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Fluorenes; Molecular Sequence Data; Peptide Biosynthesis; Peptides; Protein Binding; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors	2001
A novel approach to the synthesis of EGF-like domains: a method for the one-pot regioselective formation of the three disulfide bonds of a human blood coagulation factor VII EGF-1 analogue. The journal of peptide research : official journal of the American Peptide Society, 2002, Volume: 60, Issue:2 Topics: Amino Acid Sequence; Aspartic Acid; Chromatography, High Pressure Liquid; Circular Dichroism; Cysteine; Disulfides; Epidermal Growth Factor; Factor VII; Humans; Molecular Sequence Data; Peptides; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship	2002
The aspartimide problem in Fmoc-based SPPS. Part I. Journal of peptide science : an official publication of the European Peptide Society, 2003, Volume: 9, Issue:1 Topics: Amino Acids; Aspartic Acid; Chromatography, High Pressure Liquid; Fluorenes; Peptides	2003
The aspartimide problem in Fmoc-based SPPS. Part II. Journal of peptide science : an official publication of the European Peptide Society, 2003, Volume: 9, Issue:8 Topics: Amino Acids; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Fluorenes; Peptide Biosynthesis; Peptides; Piperidines	2003
EFFECTS OF D,1-3-PHTHALIMIDOGLUTARIMIDE AND N-PHTHALYL-D,L-ASPARTIMIDE ON RAT PREGNANCY. Journal of medicinal chemistry, 1963, Volume: 6 Topics: Abnormalities, Drug-Induced; Animals; Aspartic Acid; Female; Humans; Imides; Pharmacology; Phthalic Acids; Pregnancy; Pregnancy, Animal; Rats; Research; Thalidomide; Toxicology	1963
Synthesis of peptide sequences related to thrombospondin: factors affecting aspartimide by-product formation. The journal of peptide research : official journal of the American Peptide Society, 2003, Volume: 62, Issue:6 Topics: Amino Acid Sequence; Aspartic Acid; Cell Line, Tumor; Humans; Molecular Sequence Data; Peptides; Thrombospondins	2003
The (2-phenyl-2-trimethylsilyl)ethyl-(PTMSEL)-linker in the synthesis of glycopeptide partial structures of complex cell surface glycoproteins. Chemistry (Weinheim an der Bergstrasse, Germany), 2003, Dec-15, Volume: 9, Issue:24 Topics: Aspartic Acid; Cadherins; Diketopiperazines; Disaccharides; Fluorides; Glycopeptides; Humans; Intestinal Mucosa; Intestines; Liver; Membrane Glycoproteins; Methylene Chloride; Models, Chemical; Mucins; Piperazines; Quaternary Ammonium Compounds; Sialic Acids; Trimethylsilyl Compounds	2003
Detection and control of aspartimide formation in the synthesis of cyclic peptides. Bioorganic & medicinal chemistry letters, 2005, Feb-15, Volume: 15, Issue:4 Topics: Aspartic Acid; Combinatorial Chemistry Techniques; Lactams; Magnetic Resonance Spectroscopy; Molecular Structure; Peptides, Cyclic; Quality Control	2005
The aspartimide problem in Fmoc-based SPPS. Part III. Journal of peptide science : an official publication of the European Peptide Society, 2005, Volume: 11, Issue:10 Topics: Amino Acids; Aspartic Acid; Chromatography, High Pressure Liquid; Fluorenes; Oligopeptides	2005
Alpha- and beta- aspartyl peptide ester formation via aspartimide ring opening. Journal of peptide science : an official publication of the European Peptide Society, 2005, Volume: 11, Issue:10 Topics: Amino Acids; Aspartic Acid; Esters; Fluorenes; Imides; Isoaspartic Acid; Oligopeptides; Peptides; Spectrometry, Mass, Electrospray Ionization	2005
A convergent synthesis of N-glycopeptides. Angewandte Chemie (International ed. in English), 2006, Feb-06, Volume: 45, Issue:7 Topics: Acylation; Amino Acids; Aspartic Acid; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Erythropoietin; Glycopeptides; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Photochemistry; Spectrometry, Mass, Electrospray Ionization	2006
Limiting racemization and aspartimide formation in microwave-enhanced Fmoc solid phase peptide synthesis. Journal of peptide science : an official publication of the European Peptide Society, 2007, Volume: 13, Issue:3 Topics: Amino Acid Sequence; Amino Acids; Aspartic Acid; Fluorenes; Isomerism; Microwaves; Peptides	2007
EDOTn and MIM, new peptide backbone protecting groups. Biopolymers, 2008, Volume: 90, Issue:3 Topics: Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Hydrogen-Ion Concentration; Indoles; Molecular Structure; Peptides; Polymers	2008
1,4-diazepine-2,5-dione ring formation during solid phase synthesis of peptides containing aspartic acid beta-benzyl ester. Journal of peptide science : an official publication of the European Peptide Society, 2007, Volume: 13, Issue:11 Topics: Aspartic Acid; Esters; Molecular Structure; Peptides, Cyclic; Piperidines	2007
Problem of aspartimide formation in Fmoc-based solid-phase peptide synthesis using Dmab group to protect side chain of aspartic acid. Journal of peptide science : an official publication of the European Peptide Society, 2008, Volume: 14, Issue:3 Topics: Amino Acids; Aspartic Acid; Chemistry; Fluorenes; Isoaspartic Acid; Peptides	2008
Synthesis of poly(aspartimide)-based bio-glycoconjugates. Carbohydrate research, 2010, Jan-11, Volume: 345, Issue:1 Topics: Antiviral Agents; Aspartic Acid; Drug Design; Glycoconjugates; N-Acetylneuraminic Acid; Polymers; Solubility; Water	2010
Aspartimide modified galanin analogue antagonizes galanin action on insulin secretion. Protein and peptide letters, 2010, Volume: 17, Issue:10 Topics: Amino Acid Sequence; Animals; Aspartic Acid; Female; Galanin; Insulin; Insulin Secretion; Islets of Langerhans; Male; Molecular Sequence Data; Muscle, Smooth; Rats; Rats, Wistar; Stomach; Swine	2010
Use of Oxyma as pH modulatory agent to be used in the prevention of base-driven side reactions and its effect on 2-chlorotrityl chloride resin. Biopolymers, 2012, Volume: 98, Issue:2 Topics: Aspartic Acid; Hydrogen-Ion Concentration; Hydroxylamines; Molecular Structure; Peptides; Pregnadienes; Trityl Compounds	2012
Convergent solid-phase synthesis of N-glycopeptides facilitated by pseudoprolines at consensus-sequence Ser/Thr residues. Angewandte Chemie (International ed. in English), 2012, Nov-12, Volume: 51, Issue:46 Topics: Amino Acid Sequence; Aspartic Acid; Consensus Sequence; Glycopeptides; Molecular Sequence Data; Proline; Serine; Solid-Phase Synthesis Techniques; Threonine	2012
An advance in the chemical synthesis of homogeneous N-linked glycopolypeptides by convergent aspartylation. Angewandte Chemie (International ed. in English), 2012, Nov-12, Volume: 51, Issue:46 Topics: Amino Acid Sequence; Aspartic Acid; Glycopeptides; Molecular Sequence Data; Solid-Phase Synthesis Techniques	2012
Acid-mediated prevention of aspartimide formation in solid phase peptide synthesis. Organic letters, 2012, Oct-19, Volume: 14, Issue:20 Topics: Acids; Aspartic Acid; Hydrogen-Ion Concentration; Molecular Structure; Solid-Phase Synthesis Techniques	2012
Rapid formation of N-Glycopeptides via Cu(II)-promoted glycosylative ligation. Organic letters, 2013, Feb-15, Volume: 15, Issue:4 Topics: Amino Acid Sequence; Aspartic Acid; Catalysis; Combinatorial Chemistry Techniques; Copper; Glycopeptides; Glycosylation; Lysine; Molecular Structure	2013
A mild removal of Fmoc group using sodium azide. Amino acids, 2014, Volume: 46, Issue:2 Topics: Amino Acids; Angiotensin II; Aspartic Acid; Fluorenes; Insect Proteins; Scorpion Venoms; Sodium Azide; Solid-Phase Synthesis Techniques	2014
Structure and mechanism of an aspartimide-dependent peptide ligase in human legumain. Angewandte Chemie (International ed. in English), 2015, Mar-02, Volume: 54, Issue:10 Topics: Aspartic Acid; Cysteine Endopeptidases; Humans; Ligases; Models, Molecular; Protein Conformation	2015
New t-butyl based aspartate protecting groups preventing aspartimide formation in Fmoc SPPS. Journal of peptide science : an official publication of the European Peptide Society, 2015, Volume: 21, Issue:8 Topics: Aspartic Acid; Chromatography, High Pressure Liquid; Fluorenes; Molecular Structure; Peptides; Solid-Phase Synthesis Techniques	2015
Native Chemical Ligation to Minimize Aspartimide Formation during Chemical Synthesis of Small LDLa Protein. Chemistry (Weinheim an der Bergstrasse, Germany), 2016, Jan-18, Volume: 22, Issue:3 Topics: Adaptor Proteins, Vesicular Transport; Amino Acid Sequence; Aspartic Acid; Calcium Chelating Agents; DNA, Recombinant; Humans; Ligation; Magnetic Resonance Spectroscopy; Protein Binding; Receptors, G-Protein-Coupled; Receptors, Peptide	2016
A backbone amide protecting group for overcoming difficult sequences and suppressing aspartimide formation. Journal of peptide science : an official publication of the European Peptide Society, 2016, Volume: 22, Issue:5 Topics: Acylation; Amides; Amino Acid Sequence; Aspartic Acid; Molecular Structure; Nitrobenzenes; Peptides; Solid-Phase Synthesis Techniques	2016
The aspartimide problem persists: Fluorenylmethyloxycarbonyl-solid-phase peptide synthesis (Fmoc-SPPS) chain termination due to formation of N-terminal piperazine-2,5-diones. Journal of peptide science : an official publication of the European Peptide Society, 2019, Volume: 25, Issue:7 Topics: Amino Acid Sequence; Amino Acids; Aspartic Acid; Fluorenes; Molecular Structure; Peptides; Piperazines; Solid-Phase Synthesis Techniques	2019
Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups. Nature communications, 2020, 02-20, Volume: 11, Issue:1 Topics: Aspartic Acid; Carboxylic Acids; Cyanides; Lipoproteins, LDL; Peptides; Protein Folding; Solid-Phase Synthesis Techniques; Ubiquitin	2020
Cellulonodin-2 and Lihuanodin: Lasso Peptides with an Aspartimide Post-Translational Modification. Journal of the American Chemical Society, 2021, 08-04, Volume: 143, Issue:30 Topics: Aspartic Acid; Bacillales; Peptides; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Processing, Post-Translational; Thermobifida	2021
Kinetics of Aspartimide Formation and Hydrolysis in Lasso Peptide Lihuanodin. Biochemistry, 2023, 02-07, Volume: 62, Issue:3 Topics: Aspartic Acid; Hydrolysis; Kinetics; Peptides; Protein D-Aspartate-L-Isoaspartate Methyltransferase	2023
Genome Mining and Discovery of Imiditides, a Family of RiPPs with a Class-Defining Aspartimide Modification. Journal of the American Chemical Society, 2023, 08-30, Volume: 145, Issue:34 Topics: Algorithms; Aspartic Acid; Biological Products; Methyltransferases	2023