aspartic acid has been researched along with piperidines in 71 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (42.25) | 18.7374 |
| 1990's | 16 (22.54) | 18.2507 |
| 2000's | 18 (25.35) | 29.6817 |
| 2010's | 7 (9.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Compton, RP; Hood, WF; Monahan, JB | 1 |
| Church, J; Lodge, D | 1 |
| Carter, CJ; Lloyd, KG; Scatton, B; Zivkovic, B | 1 |
| Meldrum, BS; Swan, JH | 1 |
| Johnson, BG; McQuaid, LA; Schoepp, DD; Smith, EC | 1 |
| Allen, J; Langer, SZ; Schoemaker, H | 1 |
| Colpaert, FC; Koek, W; Woods, JH | 1 |
| Amrick, CL; Bennett, DA; Bernard, PS; Hutchison, AJ; Liebman, JM; Wilson, DE | 1 |
| Angst, C; Bernard, PS; Blanchard, L; de Jesus, R; Hutchison, AJ; Jackson, RH; Murphy, DE; Schneider, J; Williams, M; Wilusz, EJ | 1 |
| Hillman, CC; Ornstein, PL; Salhoff, CR; Schoepp, DD | 1 |
| Miller, RJ; Reynolds, IJ | 1 |
| D'Angio, M; Scatton, B; Serrano, A | 1 |
| Jackson, A; Sanger, DJ | 2 |
| France, CP; Ornstein, P; Woods, JH | 1 |
| Amrick, CL; Bennett, DA; Bernard, PS | 1 |
| Chapman, AG; Hutchison, A; Lehmann, J; Meldrum, BS; Tsai, C; Wood, PL | 1 |
| Bertin, J; Carter, C; Dupont, R; Duverger, D; Frost, J; Gaudilliere, B; Gotti, B; MacKenzie, ET; Rousseau, J; Scatton, B | 1 |
| Arbilla, S; Benavides, J; Carter, C; Legendre, P; Lloyd, KG; MacKenzie, ET; Noel, F; Thuret, F; Vincent, JD; Zivkovic, B | 1 |
| Chavkin, C; Malouf, AT; Swearengen, E | 1 |
| Hurt, SD; Hutchison, AJ; Murphy, DE; Sills, MA; Williams, M | 1 |
| Loo, PS; Sills, MA; Williams, M | 1 |
| Cross, AJ; Reynolds, GP; Slater, P | 1 |
| Hutchison, AJ; Lehmann, J; McPherson, SE; Mondadori, C; Murphy, DE; Schmutz, M; Sinton, CM; Steel, DJ; Tsai, C; Williams, M | 1 |
| Boast, CA; Etienne, PE; Gerhardt, SC; Lehmann, J; Liebman, JM; Pastor, G | 1 |
| Boast, CA; Pastor, G | 1 |
| Buckman, T | 1 |
| McConnell, HM; Ogata, RT | 2 |
| Baldassare, JJ; Bunn, HF; Ho, C; Lindstrom, TR | 1 |
| Gilvarg, C; Yugari, Y | 1 |
| Szám, I | 1 |
| Gatti, GL; Michalek, H; Pocchiari, F | 1 |
| Blake, MI; Fang, SM; Rhodes, HJ | 1 |
| Collins, JF; Jais, MM; King, DJ; McBain, AE; Roberts, CJ; Walker, RJ; Wheal, HV | 1 |
| Hill, RG; Salt, TE | 1 |
| Ackermann, J; Banner, DW; Gast, A; Gubernator, K; Hadváry, P; Hilpert, K; Labler, L; Müller, K; Schmid, G; Tschopp, TB | 1 |
| Karlström, A; Undén, A | 1 |
| DeGrado, WF; Jackson, S; Mousa, S; Olson, RE; Rafalski, M; Rockwell, A; Roderick, J; Xue, CB | 1 |
| Bellocchio, E; Edwards, RH; Fon, E; Ming, G; Poo, M; Song, H | 1 |
| Antonelli, T; Beani, L; Bianchi, C; Tomasini, C | 1 |
| Ciani, E; Contestabile, A; Dall'Olio, R; Gandolfi, O; Sparapani, M | 1 |
| Geller, HM; Greene, LA; Morris, EJ; Park, DS; Shelanski, ML; Stefanis, L; Troy, CM | 1 |
| Jordan, VC; Levenson, AS | 1 |
| Chai, YG; Hersh, LB; Kim, MH; Lim, EJ; Lu, M | 1 |
| Feligioni, M; Pattarini, R; Pittaluga, A; Raiteri, M | 1 |
| Dick, F; Mergler, M; Sax, B; Stähelin, C; Vorherr, T | 1 |
| SIEGLER, PE | 1 |
| Charles, HC; Doraiswamy, PM; Ieni, JR; Krishnan, KR; Mintzer, J; Perdomo, C; Rogers, S; Weisler, R; Yu, X | 1 |
| Bhogal, N; Blaney, FE; Findlay, JB; Ingley, PM; Rees, J | 1 |
| de Groot, MJ; Helliwell, R; Leishman, D; Mitcheson, J; Perry, M; Sanguinetti, MC; Tristani-Firouzi, M | 1 |
| Auberson, YP; Bashir, ZI; Brown, MW; Collingridge, GL; Johnson, BE; Massey, PV; Molnar, E; Moult, PR | 1 |
| Chen, N; Dutta, AK; Maiti, S; Reith, ME; Zhen, J | 1 |
| Li, DJ; Ma, L; Wang, LN; Wang, W; Yin, H; Zhang, XH | 1 |
| Bravo, DT; Kolmakova, NG; Parsons, SM | 1 |
| Kreitzer, AC; Malenka, RC | 1 |
| Terman, GW; Thomson, LM; Zeng, J | 1 |
| Shivachar, AC | 1 |
| Duffy, S; Labrie, V; Roder, JC | 1 |
| Ilas, J; Schlosser, G; Süli-Vargha, H | 1 |
| Caunt, C; Christie, BR; James, R; Kannangara, T; Samadi, S; Schibuk, E; Titterness, AK; Vasuta, C | 1 |
| Bartha, R; Borrie, MJ; Rupsingh, R; Rylett, J; Smith, M; Wells, JL | 1 |
| Nadler, JV; Zhang, X | 1 |
| Bakar, M; Gumustas, O; Parlayan, E; Yulug, B | 1 |
| Errea, JM; Fayed, N; Modrego, PJ; Pina, MA; Rios, C; Sarasa, M | 1 |
| Cunha, RA; Musante, V; Pittaluga, A; Raiteri, M; Summa, M | 1 |
| Bernardinelli, Y; Farmer, WT; Jones, EV; Murai, KK; Salmon, C; Stellwagen, D | 1 |
| Atodiresei, I; Bolm, C; Jörres, M; Schiffers, I | 1 |
| Hermann, GE; Rogers, RC; Vance, KM | 1 |
| Bozsó, Z; Fülöp, L; Juhász, G; Penke, B; Szegedi, V; Varga, E | 1 |
| Domin, H; Misztak, P; Nowak, G; Pochwat, B; Rafało-Ulińska, A; Szewczyk, B | 1 |
1 review(s) available for aspartic acid and piperidines
| Article | Year |
|---|---|
CURRENT STATUS OF DRUG TREATMENT IN THE DEPRESSIVE STATE.
Topics: Amitriptyline; Amphetamine; Amphetamines; Antidepressive Agents; Aspartic Acid; Benactyzine; Classification; Deanol; Depression; Desipramine; Humans; Imipramine; Isocarboxazid; Methylphenidate; Monoamine Oxidase Inhibitors; Nialamide; Pargyline; Pharmacology; Phenelzine; Phenmetrazine; Piperidines; Sympathomimetics; Toxicology; Tranylcypromine | 1964 |
3 trial(s) available for aspartic acid and piperidines
| Article | Year |
|---|---|
Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain Chemistry; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Hippocampus; Humans; Indans; Inositol; Magnetic Resonance Spectroscopy; Male; Neurons; Piperidines; Placebos; Psychiatric Status Rating Scales; Severity of Illness Index; Treatment Outcome | 2003 |
High field (1)H MRS of the hippocampus after donepezil treatment in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cholinesterase Inhibitors; Creatine; Donepezil; Female; Hippocampus; Humans; Indans; Inositol; Magnetic Resonance Spectroscopy; Male; Piperidines; Protons | 2008 |
Memantine versus donepezil in mild to moderate Alzheimer's disease: a randomized trial with magnetic resonance spectroscopy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Magnetic Resonance Spectroscopy; Male; Memantine; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Protons; Severity of Illness Index; Treatment Outcome | 2010 |
67 other study(ies) available for aspartic acid and piperidines
| Article | Year |
|---|---|
N-methyl-D-aspartate recognition site ligands modulate activity at the coupled glycine recognition site.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Glutamates; Glutamic Acid; Glycine; Ligands; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines | 1990 |
Failure of sigma-receptor ligands to reduce the excitatory actions of N-methyl-DL-aspartate on rat spinal neurons in-vivo.
Topics: Animals; Aspartic Acid; Haloperidol; In Vitro Techniques; Kainic Acid; Ligands; N-Methylaspartate; Neurons; Oxadiazoles; Piperidines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord; Stereoisomerism | 1990 |
Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Cells, Cultured; Drug Interactions; Female; Glycine; Male; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Spinal Cord | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Brain; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Stereoisomerism | 1990 |
Binding of [3H]ifenprodil, a novel NMDA antagonist, to a polyamine-sensitive site in the rat cerebral cortex.
Topics: Animals; Aspartic Acid; Biogenic Polyamines; Cerebral Cortex; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Piperidines; Rats; Rats, Inbred Strains | 1990 |
N-methyl-D-aspartate antagonism and phencyclidine-like activity: a drug discrimination analysis.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Injections, Intraperitoneal; Kainic Acid; Male; Mice; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains | 1990 |
Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors.
Topics: Animals; Anticonvulsants; Aspartic Acid; Conflict, Psychological; Discrimination Learning; Male; Mice; Mice, Inbred DBA; Motor Activity; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
4-(Phosphonoalkyl)- and 4-(phosphonoalkenyl)-2-piperidinecarboxylic acids: synthesis, activity at N-methyl-D-aspartic acid receptors, and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Aspartic Acid; Chemical Phenomena; Chemistry; Male; Mice; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship | 1989 |
CGS-19755 and MK-801 selectively prevent rat striatal cholinergic and gabaergic neuronal degeneration induced by N-methyl-D-aspartate and ibotenate in vivo.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Cholinergic Fibers; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Ibotenic Acid; Male; N-Methylaspartate; Nerve Degeneration; Oxazoles; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines.
Topics: Acetamides; Animals; Aspartic Acid; Brain; Calcium; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glycine; In Vitro Techniques; Ketamine; Kinetics; N-Methylaspartate; Phencyclidine; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
NMDA antagonists block restraint-induced increase in extracellular DOPAC in rat nucleus accumbens.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Carbolines; Convulsants; Diazepam; Male; N-Methylaspartate; Nucleus Accumbens; Phenylacetates; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Restraint, Physical; Riluzole; Septal Nuclei; Thiazoles | 1989 |
Conditioned taste aversions induced by phencyclidine and other antagonists of N-methyl-D-aspartate.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Avoidance Learning; Conditioning, Operant; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Taste | 1989 |
Effects of phencyclidine and other N-methyl-D-aspartate antagonists on the schedule-controlled behavior of rats.
Topics: Animals; Aspartic Acid; Conditioning, Psychological; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperazines; Piperidines; Punishment; Rats; Rats, Inbred Strains; Reinforcement Schedule; Stereoisomerism | 1989 |
The competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 attenuates the rate-decreasing effects of NMDA in rhesus monkeys without producing ketamine-like discriminative stimulus effects.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Ketamine; Macaca mulatta; Male; N-Methylaspartate; Pipecolic Acids; Piperidines | 1989 |
A comparison of PCP-like compounds for NMDA antagonism in two in vivo models.
Topics: Animals; Aspartic Acid; Behavior, Animal; Dioxolanes; Dioxoles; Ketamine; Male; Mice; Motor Activity; N-Methylaspartate; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1988 |
CGS 19755 is a potent and competitive antagonist at NMDA-type receptors.
Topics: Acetylcholine; Animals; Aspartic Acid; Binding, Competitive; Blood-Brain Barrier; Cerebellum; Cyclic GMP; Harmaline; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cats; Female; Male; Models, Cardiovascular; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Vasoconstriction | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cells, Cultured; Cerebellum; Corpus Striatum; Cyclic GMP; Dopamine; Harmaline; In Vitro Techniques; Mice; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Comparison of the actions of phencyclidine and sigma ligands on CA1 hippocampal pyramidal neurons in the rat.
Topics: Action Potentials; Animals; Aspartic Acid; Guanidines; Hippocampus; Male; N-Methylaspartate; Neurons; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1988 |
Characterization of the binding of [3H]-CGS 19755: a novel N-methyl-D-aspartate antagonist with nanomolar affinity in rat brain.
Topics: Animals; Aspartic Acid; Brain; Intracellular Membranes; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
The NMDA antagonists, CPP and CGS 19755, lack affinity for central benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Brain; Flunitrazepam; In Vitro Techniques; N-Methylaspartate; Pipecolic Acids; Piperazines; Piperidines; Rats; Receptors, GABA-A | 1988 |
Reduced high-affinity glutamate uptake sites in the brains of patients with Huntington's disease.
Topics: Aged; Aspartic Acid; Brain; Caudate Nucleus; Female; Frontal Lobe; Glutamates; Glutamic Acid; Hippocampus; Humans; Huntington Disease; Male; Middle Aged; Paroxetine; Piperidines; Putamen | 1986 |
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
Topics: Acetylcholine; Aconitine; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Binding, Competitive; Darkness; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Structure-Activity Relationship; Tetrodotoxin | 1988 |
The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils.
Topics: Animals; Aspartic Acid; Brain; Female; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Motor Activity; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines | 1988 |
Characterization of motor activity patterns induced by N-methyl-D-aspartate antagonists in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electronic Data Processing; Female; Gerbillinae; Ketamine; Motor Activity; N-Methylaspartate; Pipecolic Acids; Piperazines; Piperidines; Time Factors | 1987 |
Spin-labeling studies of aspartate transcarbamylase. I. Effects of nucleotide binding and subunit separation.
Topics: Adenosine Triphosphate; Aspartic Acid; Benzoates; Carbamates; Chemical Phenomena; Chemistry; Cyclic N-Oxides; Cytosine Nucleotides; Electron Spin Resonance Spectroscopy; Escherichia coli; Free Radicals; Hydrogen-Ion Concentration; Mercury; Nucleotides; Organometallic Compounds; Piperidines; Protein Binding; Succinates; Transferases; Uracil Nucleotides | 1970 |
Binding of triphosphate spin labels to hemoglobin Kempsey.
Topics: Adenosine Triphosphate; Asparagine; Aspartic Acid; Binding Sites; Cyanides; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Hemoglobins, Abnormal; Humans; Macromolecular Substances; Mathematics; Oxygen; Phosphoric Acids; Piperidines; Protein Binding | 1972 |
Nuclear magnetic resonance and spin-label studies of hemoglobin Kempsey.
Topics: Asparagine; Aspartic Acid; Australia; Carboxyhemoglobin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Heme; Hemoglobins; Hemoglobins, Abnormal; Humans; Inositol; Iodoacetates; Ligands; Magnetic Resonance Spectroscopy; Mutation; Organophosphorus Compounds; Piperidines; Protein Conformation; Spin Labels | 1973 |
Triphosphate spin-label studies of allosteric interactions in hemoglobin.
Topics: Adenosine Triphosphate; Allosteric Regulation; Arginine; Asparagine; Aspartic Acid; Australia; Binding Sites; Cyanides; Electron Spin Resonance Spectroscopy; Ferricyanides; Glycerophosphates; Hemoglobins; Hemoglobins, Abnormal; Humans; Kinetics; Leucine; Maryland; Mathematics; Models, Biological; Mutation; Phosphoric Acids; Piperidines; Protein Binding; Protein Conformation; Spin Labels | 1973 |
The condensation step in diaminopimelate synthesis.
Topics: Aldehydes; Aspartic Acid; Escherichia coli; In Vitro Techniques; Kinetics; Pimelic Acids; Piperidines; Pyruvates | 1965 |
[Prevention and therapy of hepatic coma].
Topics: Aged; Amides; Ammonia; Aspartic Acid; Chlorothiazide; Clopamide; Depression, Chemical; Diuretics; Female; Furosemide; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Liver Diseases; Magnesium; Male; Middle Aged; Piperidines; Potassium; Pulmonary Heart Disease; Stimulation, Chemical | 1970 |
Effect of triperidol on carbohydrate and amino acid metabolism in rat brain-cortex slices.
Topics: Amino Acids; Animals; Antidepressive Agents; Aspartic Acid; Butyrophenones; Carbohydrate Metabolism; Cerebral Cortex; Fluorine; Galactose; Glucose; Glutamates; Glycine; In Vitro Techniques; Piperidines; Pyruvates; Rats; Trifluperidol | 1968 |
Synthesis of 2,6-dioxo-3-phthalimidopiperidine-3,4,4,5,5-d, and 2,5-dioxo-3-phthalimidopyrrolidine-3,4,4-d, from L-deuterio-glutamic acid and L-deuterio-aspartic acid.
Topics: Aspartic Acid; Carbon; Chemistry, Pharmaceutical; Deuterium; Eukaryota; Glutamates; Hydrogen; Nitrogen; Piperidines; Thalidomide | 1965 |
The excitatory actions of a series of piperidine dicarboxylates on central neurons of the rat, snail, leech and horseshoe crab and on crab neuromuscular junction.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Helix, Snails; Horseshoe Crabs; In Vitro Techniques; Leeches; Neuromuscular Junction; Neurons; Piperidines; Rats; Species Specificity | 1982 |
Differentiation of excitatory amino acid receptors in the rat caudal trigeminal nucleus: a microiontophoretic study.
Topics: 2-Aminoadipic Acid; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Glutamates; Kainic Acid; Male; Oxadiazoles; Piperidines; Quisqualic Acid; Rats; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Trigeminal Nuclei | 1982 |
Design and synthesis of potent and highly selective thrombin inhibitors.
Topics: Amino Acids; Animals; Antithrombins; Aspartic Acid; Drug Design; Half-Life; Humans; Piperidines; Rats; Structure-Activity Relationship; Trypsin Inhibitors | 1994 |
Design of protecting groups for the beta-carboxylic group of aspartic acid that minimize base-catalyzed aspartimide formation.
Topics: Aspartic Acid; Chromatography, High Pressure Liquid; Esters; Oligopeptides; Piperidines; Temperature; Time Factors | 1996 |
Design, synthesis, and in vitro activities of benzamide-core glycoprotein IIb/IIIa antagonists: 2,3-diaminopropionic acid derivatives as surrogates of aspartic acid.
Topics: Alanine; Alkylation; Animals; Aspartic Acid; Benzamides; Benzamidines; Benzoates; Benzoic Acid; beta-Alanine; Carbamates; Esterases; Humans; Liver; Magnetic Resonance Spectroscopy; Oligopeptides; Piperazine; Piperazines; Piperidines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Structure-Activity Relationship; Sulfonamides; Swine | 1997 |
Expression of a putative vesicular acetylcholine transporter facilitates quantal transmitter packaging.
Topics: Acetylcholine; Animals; Aspartic Acid; Blastomeres; Carrier Proteins; Cells, Cultured; Embryo, Nonmammalian; Female; Gene Expression Regulation, Developmental; Membrane Transport Proteins; Microinjections; Muscles; Mutagenesis; Nervous System; Neuromuscular Depolarizing Agents; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Synapses; Synaptic Transmission; Synaptophysin; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins; Xenopus laevis | 1997 |
The muscarinic modulation of [3H]D-aspartate efflux and [Ca2+]i levels in rat cerebellar granule cells.
Topics: Acetylcholine; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Electric Stimulation; Muscarinic Antagonists; Neurons; Piperidines; Potassium Chloride; Rats; Receptors, Muscarinic | 1997 |
Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Aspartic Acid; Butylated Hydroxytoluene; Cells, Cultured; Cerebellar Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Free Radical Scavengers; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Piperidines; Putrescine; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Vitamin E | 1997 |
Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress.
Topics: Animals; Antimetabolites, Antineoplastic; Aphidicolin; Apoptosis; Aspartic Acid; Cell Division; Cell Survival; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Cytarabine; DNA Damage; Enzyme Inhibitors; Flavonoids; Humans; Kinetin; Nerve Growth Factors; Neurons; Oxidative Stress; PC12 Cells; Piperidines; Purines; Rats; Rats, Sprague-Dawley; S Phase; Superior Cervical Ganglion; Superoxide Dismutase; Ultraviolet Rays | 1998 |
The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor.
Topics: Aspartic Acid; Blotting, Northern; Breast Neoplasms; Estradiol; Estrogen Antagonists; Female; Humans; Mutagenesis, Site-Directed; Piperidines; Point Mutation; Raloxifene Hydrochloride; Receptors, Estrogen; RNA, Messenger; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1998 |
Mutational analysis of aspartate residues in the transmembrane regions and cytoplasmic loops of rat vesicular acetylcholine transporter.
Topics: Acetylcholine; Animals; Aspartic Acid; Carrier Proteins; Cytoplasm; Humans; Membrane Transport Proteins; Mutagenesis, Site-Directed; PC12 Cells; Piperidines; Protein Binding; Rats; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 1999 |
N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid, the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; HIV Envelope Protein gp120; Hydrogen-Ion Concentration; Male; N-Methylaspartate; Norepinephrine; Piperidines; Protein Kinase C; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Synaptosomes; Zinc | 2001 |
The aspartimide problem in Fmoc-based SPPS. Part II.
Topics: Amino Acids; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Fluorenes; Peptide Biosynthesis; Peptides; Piperidines | 2003 |
Evidence for the proximity of the extreme N-terminus of the neurokinin-2 (NK2) tachykinin receptor to Cys167 in the putative fourth transmembrane helix.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Benzamides; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cysteine; Ethyl Methanesulfonate; Extracellular Space; Glutamic Acid; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Piperidines; Protein Structure, Secondary; Receptors, Neurokinin-2; Static Electricity; Sulfhydryl Reagents; Tritium | 2004 |
Structural determinants of HERG channel block by clofilium and ibutilide.
Topics: Amino Acid Substitution; Animals; Anti-Arrhythmia Agents; Aspartic Acid; Benzopyrans; Binding Sites; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Oocytes; Phenethylamines; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Quaternary Ammonium Compounds; Serine; Sulfonamides; Tyrosine; Xenopus laevis | 2004 |
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
Interaction between a hydroxypiperidine analogue of 4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine and Aspartate 68 in the human dopamine transporter.
Topics: Animals; Aspartic Acid; Benzhydryl Compounds; Binding Sites; Binding, Competitive; Biological Transport; Cell Line; Cell Membrane; Cerebral Cortex; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Mutation; Nerve Tissue Proteins; Norepinephrine; Piperazines; Piperidines; Protein Binding; Rats; Rats, Sprague-Dawley; Serotonin; Stereoisomerism; Synaptosomes; Tritium | 2004 |
[An interventional study on amnestic mild cognitive impairment with small dose donepezil].
Topics: Aged; Aged, 80 and over; Amnesia; Aspartic Acid; Cognition; Cognition Disorders; Creatine; Donepezil; Female; Hippocampus; Humans; Indans; Inositol; Magnetic Resonance Spectroscopy; Male; Memory; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines | 2004 |
Mutational and pH analysis of ionic residues in transmembrane domains of vesicular acetylcholine transporter.
Topics: Acetylcholine; Animals; Aspartic Acid; Binding Sites; Biological Transport; Blotting, Western; Cell Line; Cell Membrane; Fluorescent Antibody Technique, Direct; Histidine; Hydrogen-Ion Concentration; Lysine; Membrane Transport Proteins; Microscopy, Confocal; Mutagenesis, Site-Directed; Piperidines; Protein Structure, Tertiary; Rats; Static Electricity; Vesicular Acetylcholine Transport Proteins | 2005 |
Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum.
Topics: Animals; Aspartic Acid; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cerebellum; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Radiation; Electric Stimulation; Endocannabinoids; Epistasis, Genetic; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Long-Term Synaptic Depression; Membrane Potentials; Methoxyhydroxyphenylglycol; Morpholines; Naphthalenes; Neurons; Nitrendipine; Patch-Clamp Techniques; Piperidines; Pyrazoles; Quinpirole; Rats; Rats, Sprague-Dawley; Sulpiride; Time Factors | 2005 |
An N-methyl-D-aspartate receptor mediated large, low-frequency, spontaneous excitatory postsynaptic current in neonatal rat spinal dorsal horn neurons.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Animals, Newborn; Aspartic Acid; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Lidocaine; Magnesium; Neural Inhibition; Patch-Clamp Techniques; Piperidines; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tetrodotoxin | 2006 |
Cannabinoids inhibit sodium-dependent, high-affinity excitatory amino acid transport in cultured rat cortical astrocytes.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Aspartic Acid; Astrocytes; Benzoxazines; Biological Transport; Biomarkers; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Cannabinoids; Cells, Cultured; Cerebral Cortex; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Excitatory Amino Acids; Glial Fibrillary Acidic Protein; Immunohistochemistry; Kinetics; L-Lactate Dehydrogenase; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Proteins; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Sodium; Time Factors | 2007 |
D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning.
Topics: Analysis of Variance; Animals; Aspartic Acid; Avoidance Learning; Behavior, Animal; Carrier Proteins; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nerve Tissue Proteins; Phenols; Piperidines; Receptors, N-Methyl-D-Aspartate; Serine; Spatial Behavior | 2008 |
1,4-diazepine-2,5-dione ring formation during solid phase synthesis of peptides containing aspartic acid beta-benzyl ester.
Topics: Aspartic Acid; Esters; Molecular Structure; Peptides, Cyclic; Piperidines | 2007 |
Effects of exercise on NMDA receptor subunit contributions to bidirectional synaptic plasticity in the mouse dentate gyrus.
Topics: Animals; Aspartic Acid; Behavior, Animal; Dentate Gyrus; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agents; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Neurons; Physical Conditioning, Animal; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 2007 |
Postsynaptic response to stimulation of the Schaffer collaterals with properties similar to those of synaptosomal aspartate release.
Topics: Animals; Animals, Newborn; Aspartic Acid; Calcium; Calcium Channels, P-Type; Calcium Channels, Q-Type; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Neural Pathways; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Phenols; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Synaptosomes | 2009 |
Neurometabolic correlations of donepezil and rivastigmine in dementia patients: a different neuroprotective effect.
Topics: Aged; Aspartic Acid; Brain; Cognition Disorders; Dementia; Donepezil; Female; Humans; Indans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Phenylcarbamates; Piperidines; Psychiatric Status Rating Scales; Rivastigmine; Treatment Outcome | 2009 |
Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions.
Topics: Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Immunoprecipitation; Magnesium; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tetrahydronaphthalenes; Tritium | 2011 |
Astrocytes display complex and localized calcium responses to single-neuron stimulation in the hippocampus.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Bacterial Proteins; Benzoates; Benzoxazines; Calcium; Calcium Channel Blockers; Carbenoxolone; Channelrhodopsins; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Glial Fibrillary Acidic Protein; Glycine; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Luminescent Proteins; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Models, Biological; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Peptide Fragments; Phosphopyruvate Hydratase; Photic Stimulation; Piperidines; Pyrazoles; Pyridines; Sodium Channel Blockers; Statistics, Nonparametric; Tetanus Toxin; Tetrodotoxin; Transduction, Genetic | 2011 |
Asymmetric Michael additions of α-nitrocyclohexanone to aryl nitroalkenes catalyzed by natural amino acid-derived bifunctional thioureas.
Topics: Alkenes; Amino Acids; Aspartic Acid; Catalysis; Glutamic Acid; Molecular Structure; Nitro Compounds; Piperidines; Pyrrolidines; Stereoisomerism; Thiourea | 2012 |
NMDA receptors control vagal afferent excitability in the nucleus of the solitary tract.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Afferent Pathways; Animals; Aspartic Acid; Benzimidazoles; Calcium; Excitatory Amino Acid Antagonists; In Vitro Techniques; Piperidines; Pregnenolone; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Sulfonamides; Vagus Nerve | 2015 |
Amyloid-β1-42 Disrupts Synaptic Plasticity by Altering Glutamate Recycling at the Synapse.
Topics: Alanine Transaminase; Amyloid beta-Peptides; Analysis of Variance; Animals; Aspartic Acid; Biophysics; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred BALB C; Nerve Net; Neuronal Plasticity; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Pyruvic Acid; Synapses | 2015 |
Involvement of extracellular signal-regulated kinase (ERK) in the short and long-lasting antidepressant-like activity of NMDA receptor antagonists (zinc and Ro 25-6981) in the forced swim test in rats.
Topics: Animals; Antidepressive Agents; Aspartic Acid; Butadienes; Depressive Disorder; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Male; Motor Activity; Nitriles; Organometallic Compounds; Phenols; Phosphorylation; Piperidines; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Time Factors; Zinc Compounds | 2017 |