aspartic acid has been researched along with organophosphonates in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (52.17) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Opella, SJ; Phillips, HM; Roberts, MF; Schaffer, MH; Stark, GR | 1 |
| Brand, SS; Curtis, DR; Watkins, JC | 1 |
| Keppler, DD | 1 |
| Bothwell, MA; Gibbons, I; Schachman, HK; Subramani, S; Yang, YR | 1 |
| Duś, D; Kafarski, P; Lejczak, B; Mastalerz, P; Radzikowski, C | 1 |
| Seaver, SS; Stark, GR; Swyryd, EA | 1 |
| Hoogenraad, J; Stark, GR; Yoshida, T | 1 |
| Chamberlin, MJ; Gray, CW; Gray, DM | 1 |
| Jacobson, GR; Stark, GR | 1 |
| Collins, KD; Stark, GR | 1 |
| Baldeschwieler, JD; Schmidt, PG; Stark, GR | 1 |
| Davies, J; Jones, AW; Sheardown, MJ; Smith, DA; Watkins, JC | 1 |
| De Choszczak, MP; Kafarski, P; Lejczak, B | 1 |
| Hamilton, R; Walker, B; Walker, BJ | 1 |
| Cox, RJ; Gibson, JS; Mayo Martín, MB | 1 |
| Zheng, S; Zuo, Z | 1 |
| Cardia, JP; Eldo, J; Kantrowitz, ER; O'Day, EM; Tsuruta, H; Xia, J | 1 |
| Cakir, N; Midilli, K; Pamuk, ON; Umit, H | 1 |
| Claperon, C; Inguimbert, N; Iturrioz, X; Llorens-Cortes, C; Maigret, B; Okada, M; Roques, B; Rozenfeld, R | 1 |
| Alagozlu, H; Coskun, M; Koksal, B; Ozdemir, O; Yilmaz, A | 1 |
| Beyersdorf, MS; Bottone, CJ; Crane, BR; Halkides, CJ; Lookadoo, DB; Lynch, MJ; Sircar, R | 1 |
| Andrei, G; Buckheit, RW; De Jonghe, S; Groaz, E; Hartman, T; Herdewijn, P; Kalkeri, R; Luo, M; Ptak, RG; Schols, D; Snoeck, R | 1 |
| Del Corte, X; López-Francés, A; Maestro, A; Palacios, F; Vicario, J | 1 |
23 other study(ies) available for aspartic acid and organophosphonates
| Article | Year |
|---|---|
Evidence from 13C NMR for protonation of carbamyl-P and N-(phosphonacetyl)-L-aspartate in the active site of aspartate transcarbamylase.
Topics: Aspartic Acid; Binding Sites; Carbamates; Carbamyl Phosphate; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Organophosphonates; Protein Binding; Structure-Activity Relationship | 1976 |
Phosphonic analogues as antagonists of amino acid excitants.
Topics: Amino Acids; Animals; Aspartic Acid; Cats; Excitatory Amino Acid Antagonists; Glutamates; Organophosphonates; Spinal Cord | 1977 |
Aspartate carbamoyltransferase inhibition and uridylate trapping result in a synergistic depression of uridine triphosphate in hepatoma cells.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carcinoma, Hepatocellular; Cells, Cultured; Female; Galactosamine; Kinetics; Liver Neoplasms; Neoplasms, Experimental; Organophosphonates; Rats; Uracil Nucleotides | 1977 |
Ligand-promoted weakening of intersubunit bonding domains in aspartate transcarbamolylase.
Topics: Aspartate Carbamoyltransferase; Aspartic Acid; Binding Sites; Drug Stability; Escherichia coli; Kinetics; Ligands; Macromolecular Substances; Organophosphonates; Osmolar Concentration; Temperature | 1977 |
N-(Phosphonoacetyl)amino phosphonates. Phosphonate analogues of N-(phosphonoacetyl)-L-aspartic acid (PALA).
Topics: Aspartic Acid; Cell Line; Chemical Phenomena; Chemistry; Humans; Mouth Neoplasms; Organophosphonates; Organophosphorus Compounds; Phosphonoacetic Acid; Structure-Activity Relationship | 1985 |
N-(phosphonacetyl)-L-aspartate, a potent transition state analog inhibitor of aspartate transcarbamylase, blocks proliferation of mammalian cells in culture.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Bicarbonates; Carbamates; Carbon Radioisotopes; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chromatography, Ion Exchange; Fibroblasts; Haplorhini; Kidney; Kinetics; Mice; Mice, Inbred Strains; Organophosphonates; Organophosphorus Compounds; Phosphonoacetic Acid; Simian virus 40; Species Specificity; Time Factors; Tritium; Uridine | 1974 |
Inhibition by N-(phosphonacetyl)-L-aspartate of aspartate transcarbamylase activity and drug-induced cell proliferation in mice.
Topics: Administration, Oral; Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carbon Radioisotopes; Cell Division; DNA; Female; Injections, Subcutaneous; Isoproterenol; Jejunum; Mice; Organophosphonates; Phosphonoacetic Acid; Spleen; Submandibular Gland; Thymidine; Time Factors; Tritium | 1974 |
Interaction of aspartate transcarbamylase with regulatory nucleotides.
Topics: Acetates; Adenosine Triphosphate; Allosteric Regulation; Aspartate Carbamoyltransferase; Aspartic Acid; Binding Sites; Circular Dichroism; Cytosine Nucleotides; Dialysis; Enzyme Activation; Escherichia coli; Organophosphonates; Peptides; Protein Conformation; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Temperature | 1973 |
Aspartate transcarbamylase. A study of possible roles for the sulfhydryl group at the active site.
Topics: Allosteric Regulation; Aspartate Carbamoyltransferase; Aspartic Acid; Benzoates; Binding Sites; Carbamates; Catalysis; Chemical Phenomena; Chemistry; Disulfides; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Hydrogen-Ion Concentration; Ligands; Macromolecular Substances; Nitro Compounds; Organophosphonates; Organophosphorus Compounds; Oxidation-Reduction; Potassium Permanganate; Protein Conformation; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfhydryl Compounds; Ultracentrifugation | 1973 |
Aspartate transcarbamylase. Interaction with the transition state analogue N-(phosphonacetyl)-L-aspartate.
Topics: Acetates; Aspartic Acid; Binding Sites; Carbamates; Catalysis; Chemical Phenomena; Chemistry; Drug Stability; Escherichia coli; Hydrazines; Lithium; Maleates; Mathematics; Organophosphonates; Phosphonoacetic Acid; Phosphoric Acids; Protein Binding; Protein Conformation; Spectrophotometry; Succinates; Transferases; Ultraviolet Rays | 1971 |
Aspartate transcarbamylase. A nuclear magnetic resonance study of the binding of inhibitors and substrates to the catalytic subunit.
Topics: Amides; Aspartic Acid; Binding Sites; Carbamates; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Methods; Organophosphonates; Phosphates; Rotation; Temperature; Transferases | 1969 |
Phosphono dipeptides and piperazine derivatives as antagonists of amino acid-induced and synaptic excitation in mammalian and amphibian spinal cord.
Topics: Amino Acids; Animals; Aspartic Acid; Cats; Dipeptides; Glutamates; Glutamine; Organophosphonates; Piperazines; Rana temporaria; Rats; Species Specificity; Spinal Cord; Synaptic Transmission | 1984 |
Inhibition of aminopeptidases by phosphonic acid and phosphinic acid analogues of aspartic and glutamic acids.
Topics: Aminopeptidases; Animals; Aspartic Acid; Cytosol; Glutamates; Glutamic Acid; Kidney; Kinetics; Microsomes; Organophosphonates; Phosphinic Acids; Swine | 1993 |
Synthesis and proteinase inhibitory properties of diphenyl phosphonate analogues of aspartic and glutamic acids.
Topics: Aspartic Acid; Catalysis; Glutamic Acid; Hydrolysis; Kinetics; Organophosphonates; Protease Inhibitors; Serine Endopeptidases | 1998 |
Aspartyl phosphonates and phosphoramidates: the first synthetic inhibitors of bacterial aspartate-semialdehyde dehydrogenase.
Topics: Amides; Aspartate-Semialdehyde Dehydrogenase; Aspartic Acid; Bacterial Proteins; Binding Sites; Enzyme Inhibitors; Escherichia coli; Kinetics; Organophosphonates; Phosphoric Acids; Protein Binding; Structure-Activity Relationship | 2002 |
Isoflurane preconditioning reduces purkinje cell death in an in vitro model of rat cerebellar ischemia.
Topics: Amino Acid Transport System X-AG; Anesthetics, Inhalation; Animals; Aspartic Acid; Brain Ischemia; Cell Death; Cell Survival; Cerebellar Diseases; Disease Models, Animal; Glyburide; Ischemic Preconditioning; Isoflurane; Male; Nerve Degeneration; Organ Culture Techniques; Organophosphonates; Potassium Channel Blockers; Purkinje Cells; Rats; Rats, Sprague-Dawley | 2003 |
N-phosphonacetyl-L-isoasparagine a potent and specific inhibitor of Escherichia coli aspartate transcarbamoylase.
Topics: Asparagine; Aspartate Carbamoyltransferase; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Escherichia coli; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Structure; Organophosphonates; Phosphonoacetic Acid | 2006 |
Successful treatment with adefovir of one patient whose cryoglobulinemic vasculitis relapsed under lamivudine therapy and who was diagnosed to have HBV virologic breakthrough with YMDD mutations.
Topics: Adenine; Amino Acid Motifs; Aspartic Acid; Cryoglobulinemia; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Methionine; Middle Aged; Mutation; Organophosphonates; Recurrence; Tyrosine; Vasculitis | 2006 |
Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity.
Topics: Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Binding Sites; Calcium; CHO Cells; Cricetinae; Cricetulus; Enzyme Inhibitors; Glutamates; Glutamyl Aminopeptidase; Kinetics; Mice; Models, Molecular; Mutagenesis, Site-Directed; Organophosphonates; Substrate Specificity; Sulfhydryl Compounds | 2008 |
Prevelance of common YMDD motif mutations in long term treated chronic HBV infections in a Turkish population.
Topics: Adenine; Adult; Aged; Amino Acid Motifs; Anti-HIV Agents; Antiviral Agents; Aspartic Acid; Case-Control Studies; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Methionine; Middle Aged; Mutation; Organophosphonates; Prognosis; Retrospective Studies; Turkey; Tyrosine | 2013 |
Production, characterization, and assessment of a stable analog of the response regulator CheY-phosphate from Thermotoga maritima.
Topics: Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Binding Sites; Chemotaxis; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Flagella; Gene Expression; Kinetics; Methyl-Accepting Chemotaxis Proteins; Models, Molecular; Organophosphonates; Peptides; Phosphorylation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Engineering; Protein Interaction Domains and Motifs; Recombinant Proteins; Thermotoga maritima | 2017 |
Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Aspartic Acid; Cell Line; Cytomegalovirus; Drug Resistance, Viral; Drug Stability; Esters; Hepatitis B virus; Herpesvirus 3, Human; Humans; Hydrogen-Ion Concentration; Microsomes, Liver; Nucleosides; Organophosphonates; Prodrugs; Stereoisomerism; Structure-Activity Relationship | 2017 |
Synthesis of Tetrasubstituted Phosphorus Analogs of Aspartic Acid as Antiproliferative Agents.
Topics: Antineoplastic Agents; Aspartic Acid; Cell Line, Tumor; Humans; Organophosphonates; Phosphorus | 2022 |