aspartic acid has been researched along with n-methylaspartate in 1132 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 807 (71.29) | 18.7374 |
| 1990's | 248 (21.91) | 18.2507 |
| 2000's | 61 (5.39) | 29.6817 |
| 2010's | 14 (1.24) | 24.3611 |
| 2020's | 2 (0.18) | 2.80 |
| Authors | Studies |
|---|---|
| Calligaro, DO; Heinz, LJ; Lunn, WH; O'Malley, PJ; Salhoff, CR; Schoepp, DD; Vasileff, RT | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Davies, J; Evans, RH; Francis, AA; Watkins, JC | 1 |
| Beal, MF; Finn, SF; Kowall, NW; Mazurek, MF; Storey, E | 1 |
| Amin, S; Leitner, M; Rosenberg, PA | 1 |
| Carbone, S; Moguilevsky, JA; Otero Losada, ME; Szwarcfarb, B | 1 |
| Kurtz, HJ; Larson, AA; Skilling, SR; Sun, X | 1 |
| Rekling, JC | 1 |
| Abarca, J; Bradberry, CW; Bustos, G; Forray, MI; Gysling, K; Roth, RH | 1 |
| Chuang, DM; Gao, XM; Paul, SM | 1 |
| Coyle, JT; Tasker, RC; Vornov, JJ | 1 |
| Chizhmakov, IV; Jackson, H; Kiskin, NI; Krishtal, OA; Mueller, AL | 1 |
| Cazalets, JR; Clarac, F; Sqalli-Houssaini, Y | 1 |
| Pittaluga, A; Raiteri, M | 1 |
| Attwell, D; Miller, B; Sarantis, M; Traynelis, SF | 1 |
| Fain, GL; Yazejian, B | 1 |
| Davies, JA; Dickie, BG; Lewis, MJ | 1 |
| Bruno, V; Canonico, PL; Casabona, G; Catania, MV; Nicoletti, F; Scapagnini, U; Sortino, MA | 1 |
| Anderson, KJ; Mitchell, JJ | 1 |
| Blazynski, C; Linn, DM; Massey, SC; Redburn, DA | 1 |
| Beal, MF; Finn, SF; Kowall, NW; Mazurek, MF; Swartz, KJ | 1 |
| Chernevskaya, NI; Krishtal, OA; Obukhov, AG | 1 |
| van den Pol, AN | 1 |
| Kirsch, JF; Toney, MD | 1 |
| Carter, AJ; Müller, RE | 1 |
| Gannon, RL; Terrian, DM | 1 |
| Onodera, K; Takeuchi, A | 1 |
| Bagust, J; Gardner, CR; Hussain, S; Walker, RJ | 1 |
| Oja, SS; Saransaari, P | 2 |
| Dumpis, MA; Kiskin, NI; Krishtal, OA; Piotrovsky, LB | 1 |
| Adams, RN; Cammack, J; Ghasemzadeh, B | 1 |
| Morita, Y; Nishimura, S; Sorimachi, M | 1 |
| Henselmans, JM; Hoogland, PV; Stoof, JC | 1 |
| Billard, JM; Daniel, H; Pumain, R | 1 |
| Galletly, NP; Isacson, O; Sofroniew, MV; Svendsen, CN | 1 |
| Anderson, PS; Britcher, SF; Christy, ME; Lyle, PA; Lyle, TA; Magill, CA; Schwering, JE; Thies, JE; Thompson, WJ; Varga, SL | 1 |
| Albuquerque, EX; Alkondon, M; Aronstam, RS; Costa, AC; Radhakrishnan, V | 1 |
| Bennett, MV; Lerma, J; Zukin, RS | 1 |
| Chow, CC; McNamara, JO; Morrisett, RA; Sakaguchi, T; Shin, C | 1 |
| Ohmori, H; Yamaguchi, K | 1 |
| Albin, RL; Anderson, KD; Balfour, R; Handelin, B; Markel, DS; Penney, JB; Reiner, A; Tourtellotte, WW; Young, AB | 1 |
| Oles, RJ; Singh, L; Tricklebank, MD | 1 |
| Ascher, P; Johnson, JW | 1 |
| Cull-Candy, SG; Traynelis, SF | 1 |
| Jahr, CE; Stevens, CF | 2 |
| Bonhaus, DW; Hosford, DA; McNamara, JO | 1 |
| Sprosen, TS; Woodruff, GN | 1 |
| Lanthorn, TH; Monaghan, DT; Watson, GB | 1 |
| Carlsson, A; Carlsson, M | 1 |
| Burnett, DM; Dunwiddie, TV; Harris, RA; Wafford, KA | 1 |
| Brackley, P; Goodnow, R; Nakanishi, K; Sudan, HL; Usherwood, PN | 1 |
| Dichter, M; Morad, M; Tang, CM | 1 |
| Finch, DM; Fisher, RS; Jackson, MB | 1 |
| Larson, AA; Skilling, SR; Smullin, DH | 1 |
| Gündel, J; Matthies, H; Steinhäuser, C | 1 |
| Colquhoun, D; Cull-Candy, SG; Howe, JR | 2 |
| Corden, M; Curry, K; McLennan, H | 1 |
| Hoehn, K; White, TD | 1 |
| Brehm, L; Jørgensen, FS; Krogsgaard-Larsen, P; Madsen, U; Schaumburg, K | 1 |
| Fujiwara, M; Fukunaga, R; Kameyama, M; Ninomiya, H; Shimohama, S; Taniguchi, T | 1 |
| Ziskind-Conhaim, L | 1 |
| Ohno, Y; Warnick, JE | 1 |
| Compton, RP; Hood, WF; Monahan, JB | 1 |
| Bommarito, M; Johnston, MV; McDonald, JW; Silverstein, FS | 1 |
| Church, J; Lodge, D | 3 |
| Grudt, TJ; Jahr, CE | 1 |
| Anderson, EG; Grigg, JJ | 1 |
| Atsuta, Y; Garcia-Rill, E; Ishikawa, Y; Kinjo, N; Skinner, RD; Webber, M | 1 |
| Carter, CJ; Lloyd, KG; Scatton, B; Zivkovic, B | 1 |
| Harrison, PH | 1 |
| Adams, PR; Guido, W; Lu, SM; Scharfman, HE; Sherman, SM | 1 |
| Dresse, A; Massotte, L; Seutin, V; Verbanck, P | 1 |
| Dalkara, T; Erdemli, G; Onur, R | 1 |
| Albers, GW | 1 |
| Drapeau, C; Pellerin, L; Rostworowski, K; Wolfe, LS | 1 |
| Benveniste, M; Mayer, ML; Mienville, JM; Sernagor, E | 1 |
| Glaum, SR; Miller, RJ; Scholz, WK | 1 |
| Davis, M; Melia, KR; Miserendino, MJ; Sananes, CB | 1 |
| Cox, JA; Felder, CC; Henneberry, RC | 1 |
| Attwell, D; Sarantis, M | 1 |
| Markram, H; Segal, M | 1 |
| Butterworth, RF; Cotman, CW; Giguere, JF; Peterson, C | 1 |
| Okamoto, K; Sakai, Y; Sekiguchi, M | 2 |
| Clements, JD; Jahr, CE; Lester, RA; Westbrook, GL | 1 |
| Akaike, N; Murase, K; Nakagawa, T; Shirasaki, T; Tateishi, N | 1 |
| Baimbridge, KG; Choi, DW; Koh, J; Weiss, JH | 1 |
| Nistri, A; Sivilotti, L; Welsh, DM | 1 |
| Choi, DW | 1 |
| Bockaert, J; Dumuis, A; Oomagari, K; Pin, JP; Sebben, M | 1 |
| Baimbridge, KG; Kessler, M; Lynch, G; Oliver, MW; Shacklock, JA | 1 |
| Becquet, D; Faudon, M; Hery, F | 1 |
| Britt, M; Chapdelaine, MJ; Keith, RA; LaMonte, D; Mangano, TJ; Patel, J; Powel, RJ; Pullan, LM; Stumpo, RJ; Warwick, PJ | 1 |
| Hestrin, S; Nicoll, RA; Sah, P | 2 |
| Raigorodsky, G; Urca, G | 3 |
| Fink, K; Göthert, M; Schlicker, E | 1 |
| Reymann, KG; Schröder, H | 1 |
| Ohe, Y; Pan-Hou, H; Suda, Y; Sumi, M; Yoshioka, M | 1 |
| Bockaert, J; Didier, M; Heaulme, M; Pin, JP; Soubrié, P | 1 |
| Nicholson, C; Rice, ME | 1 |
| Boos, R; Müller, F; Wässle, H | 1 |
| Collingridge, GL; Davies, SN | 1 |
| Keith, R; Patel, J; Salama, A; Thompson, C; Zinkand, WC | 1 |
| Bigot, D; Hunt, SP | 1 |
| Donoso, AO; López, FJ; Negro-Vilar, A | 1 |
| Ben-Ari, Y; Cherubini, E; Corradetti, R; Gaiarsa, JL | 1 |
| Donald, AE; Foster, AC; Hutson, PH; Iversen, LL; Iversen, SD; Kemp, JA; Leeson, PD; Marshall, GR; Oles, RJ; Singh, L | 1 |
| Kouda, T; Ogawa, Y; Ogita, K; Yoneda, Y | 1 |
| Cotman, CW; Krause, JD; Nangel-Taylor, K; Palmer, E; Roxas, A | 1 |
| Ikeda, H; Kay, CD; Robbins, J | 2 |
| Massey, SC; Miller, RF | 2 |
| Schmidt, JT | 1 |
| Colpaert, FC; Koek, W | 1 |
| Mehta, AK; Ticku, MK | 1 |
| Girault, JA; Greengard, P; Halpain, S | 1 |
| Costa, E; Eimerl, S; Schramm, M | 1 |
| Hansen, AJ; Honoré, T; Jacobsen, P; Nielsen, EO; Sheardown, MJ | 1 |
| Köller, H; Müller, HW; Schmalenbach, C; Siebler, M | 1 |
| Hunt, A; Patel, AJ; Sanfeliu, C | 1 |
| Shimamura, AP | 1 |
| Britcher, SF; Denny, GH; Kemp, JA; Knight, AR; Lyle, TA; Magill, CA; Marshall, GR; Middlemiss, DN; Murphy, JS; Thompson, WJ | 1 |
| Butler, TW; Butterfield, GC; Chenard, BL; Dominy, BW; Lipinski, CA; Marinovic, LC; Mena, EE; Pagnozzi, M; Ronau, RT; Tsang, T | 1 |
| Dutton, GR; Philibert, RA; Rogers, KL | 1 |
| Keana, JF; Parker, JD; Quarum, ML; Weber, E | 1 |
| Kozikowski, AP; Pang, YP | 1 |
| Cline, HT; Constantine-Paton, M; Debski, EA | 2 |
| Choi, DW; Hartley, DM; Koh, J; Weiss, JH | 1 |
| Dilworth, V; Farah, JM; Iyengar, S; Michel, J; Mick, S; Rao, TS; Wood, PL | 1 |
| Meldrum, BS; Swan, JH | 1 |
| Cline, HT; Constantine-Paton, M | 2 |
| Kesingland, AC; Singh, L; Tricklebank, MD; Wong, EH | 1 |
| Ikin, AF; Kloog, Y; Sokolovsky, M | 1 |
| Halsey, MJ; Meldrum, BS; Millan, MH; Wardley-Smith, B | 2 |
| Osborne, NN | 1 |
| Echevarria, E; Hughes, J; Hunter, JC; Robles, L; Tortella, FC | 1 |
| Johnson, KM; Jones, SM | 2 |
| Ascher, P; Henderson, G; Johnson, JW; Sather, W | 1 |
| Carlsson, M; Svensson, A | 1 |
| Di Chiara, G; Morelli, M | 1 |
| Keith, RA; Klika, AB; Mangano, TJ; Patel, J; Salama, AI; Zinkand, WC | 1 |
| Bear, MF; Feldman, D; Press, WA; Sherin, JE | 1 |
| Gonzales, RA; Woodward, JJ | 2 |
| Nicklas, WJ; Zeevalk, GD | 2 |
| Biesterfeldt, JP; Compton, RP; Cordi, AA; Hood, WF; Lanthorn, TH; Monahan, JB; Vazquez, MI; Wood, PL | 1 |
| Boksa, P; Kohn-Alexander, J; Mount, H; Quirion, R | 1 |
| De Montigny, C; Debonnel, G; Junien, JL; Monnet, FP | 1 |
| Oles, R; Singh, L; Woodruff, G | 1 |
| Feig, S; Lipton, P | 1 |
| Berrino, L; Loffreda, A; Maione, S; Marmo, E; Matera, MG; Vitagliano, S | 1 |
| Bourguignon, JP; Franchimont, P; Gerard, A; Mathieu, A; Mathieu, J | 1 |
| Courtney, MJ; Lambert, JJ; Nicholls, DG | 1 |
| Akita, K; Ino, H; Kudo, Y; Mikoshiba, K; Miyawaki, A; Ogura, A; Yuzaki, M | 1 |
| Mayer, ML; Patneau, DK | 1 |
| Scherer, WJ; Udin, SB | 2 |
| Choi, DW; Hartley, DM; Monyer, H | 1 |
| Johnson, BG; McQuaid, LA; Schoepp, DD; Smith, EC | 1 |
| Cler, J; Emmett, MR; Iyengar, S; Mick, S; Oei, E; Rao, TS; Wood, PL | 1 |
| Aniksztejn, L; Ben-Ari, Y | 1 |
| Masetto, S; Prigioni, I; Russo, G; Valli, P | 1 |
| Greengard, P; Halpain, S | 1 |
| Coenen, AM; Peeters, BW; van Rijn, CM; Vossen, JM | 1 |
| Akaike, N; Fukuda, A; Nakagawa, T; Shirasaki, T; Wakamori, M | 1 |
| Costa, E; Lazarewicz, JW; Wroblewski, JT | 1 |
| Faden, AI; Yum, SW | 1 |
| Estienne, MJ; Green, MA; Hayes, SH; Hileman, SM; Schillo, KK | 1 |
| Allen, J; Langer, SZ; Schoemaker, H | 1 |
| Johnston, MV; McDonald, JW; Silverstein, FS | 3 |
| Cruz, LJ; Haack, JA; Mena, EE; Olivera, BM; Parks, TN; Rivier, J | 1 |
| Bingmann, D; Speckmann, EJ; Straub, H; Walden, J | 1 |
| Euerby, MR | 1 |
| Bucholtz, DC; Ebling, FJ; Foster, DL; Karsch, FJ; Schall, RE; Suttie, JM; Vannerson, LA; Wood, RI | 1 |
| Gennings, C; Kapetanovic, IM; Kupferberg, HJ; Torchin, CD | 1 |
| Choi, DW; Monyer, H | 1 |
| Labruyere, J; Olney, JW; Price, MT; Zorumski, C | 1 |
| Cazalets, JR; Clarac, F; Cremieux, J; Grillner, P; Menard, I | 1 |
| Lovinger, DM; Weight, FF; White, G | 2 |
| Atsuta, Y; Garcia-Rill, E; Kinjo, N; Kyle, R; Skinner, RD; Webber, M | 1 |
| Abraham, WC; Mason, SE; Ward, L | 1 |
| Susel, Z | 1 |
| Daniell, LC | 1 |
| Adu, J; Burgoyne, RD; Cambray-Deakin, MA | 1 |
| Ogita, K; Suzuki, T; Yoneda, Y | 2 |
| Dean, P; Keay, KA; Redgrave, P | 1 |
| Colpaert, FC; Koek, W; Woods, JH | 1 |
| De Bilbao, F; Lamour, Y; Senut, MC | 1 |
| Herreras, O; Martín del Río, R; Menéndez, N; Sánchez Herranz, A; Solís, JM | 1 |
| Godfraind, JM | 1 |
| Ferin, M; Luckhaus, J; Reyes, A | 1 |
| Farrington, R; Ingram, CD; Juss, TS; Wakerley, JB | 1 |
| Rogers, BC; Tilson, HA | 2 |
| McClellan, AD | 1 |
| Acuff, CG; Clower, BR; Rockhold, RW | 2 |
| Barolet, AW; Baskys, A; Bernstein, NK; Carlen, PL | 1 |
| Nomura, Y; Zhao, XH | 1 |
| Gilbert, ME; Mack, CM | 1 |
| Bachelard, HS; Badar-Goffer, RS; Ben-Yoseph, O; Dolin, SJ; Morris, PG | 1 |
| Erdö, SL; Michler, A | 1 |
| de Montigny, C; Debonnel, G; Monnet, FP | 1 |
| Hansen, AJ; Lauritzen, M; Wieloch, T; Zhang, ET | 1 |
| Buchan, A; Pulsinelli, WA | 1 |
| Kulkarni, SK; Mehta, AK; Ticku, MK | 1 |
| Darlington, CL; Sansom, AJ; Smith, PF | 1 |
| Back, SA; Gorenstein, C | 1 |
| Upchurch, M; Wehner, JM | 1 |
| Connick, JH; Mally, J; Stone, TW | 1 |
| Carpenter, DO; Ffrench-Mullen, JM; Hori, N | 4 |
| Michl, J; Ujec, E; Vlachová, V; Vyklický, L; Vyskocil, F | 1 |
| Crill, WE; Flatman, JA; Schwindt, PC | 1 |
| Orrego, F; Riveros, N | 1 |
| Aanonsen, LM; Wilcox, GL | 3 |
| Fischbach, GD; O'Brien, RJ | 1 |
| Crill, WE; Flatman, JA; Schwindt, PC; Spain, W; Stafstrom, CE | 1 |
| Jordan, W; Sutor, B; Zieglgänsberger, W | 1 |
| Cherubini, E; King, AE; Nistri, A | 1 |
| Fagg, GE | 1 |
| MacDonald, JF; Miljkovic, Z; Pennefather, P | 1 |
| Barker, JL; MacDermott, AB; Mayer, ML; Smith, SJ; Westbrook, GL | 1 |
| Ben-Ari, Y; Cherubini, E; Neuman, R | 2 |
| Bean, BP; Huettner, JE | 1 |
| Forsythe, ID; Nelson, PG | 1 |
| Garthwaite, G; Garthwaite, J | 9 |
| Bertolino, M; Costa, E; Mazzetta, J; Vicini, S | 1 |
| Connor, JA; Hockberger, PE; Wadman, WJ; Wong, RK | 1 |
| Rothman, S | 1 |
| Albuquerque, EX; Ramoa, AS | 1 |
| DeLander, GE; Wahl, JJ | 3 |
| Ascher, P; Bregestovski, P; Nowak, L | 1 |
| Cull-Candy, SG; Howe, JR; Ogden, DC | 1 |
| Edwards, C; Krusek, J; Vyklicky, L | 1 |
| Dolin, SJ; Halsey, MJ; Hunter, AB; Little, HJ | 1 |
| Johnson, KM; Morter, RS; Snell, LD | 2 |
| Bennett, MV; Kushner, L; Lerma, J; Zukin, RS | 2 |
| Huettner, JE | 1 |
| Albuquerque, EX; Lima-Landman, MT | 1 |
| Gruol, DL; Joels, M; Yool, AJ | 1 |
| Moran, J; Patel, AJ | 1 |
| Cull-Candy, SG; Gallo, V; Usowicz, MM | 1 |
| Ahier, RG; Middlemiss, DN; Price, GW; Singh, L; Tricklebank, MD; Wong, EH | 1 |
| Bonhaus, DW; McNamara, JO; Skaryak, L; Yeh, GC | 1 |
| Murase, K; Randic, M; Ryu, PD | 1 |
| Copenhagen, DR; Jahr, CE | 1 |
| Heinemann, S; Hollmann, M; O'Shea-Greenfield, A; Rogers, SW | 1 |
| Kuhn, D; Mayer, ML; Sernagor, E; Vyklicky, L | 1 |
| Hiromi, K; Inoue, K; Inoue, Y; Kagamiyama, H; Kuramitsu, S; Morino, Y; Tanase, S | 1 |
| Abraham, WC; Kirk, RC; McNaughton, N; Tan, S | 1 |
| Cherniack, NS; Deal, EC; Haxhiu, MA; van Lunteren, E | 1 |
| Ceserani, R; Gaviraghi, G; Maraia, G; Reggiani, A | 1 |
| Finch, CE; Kohama, SG; May, PC | 1 |
| Chapman, AG; Dürmuller, N; Lees, GJ; Meldrum, BS | 1 |
| Belaidi, M; Kamenka, JM; Lerner-Natoli, M; N'Gouemo, P; Rondouin, G | 1 |
| Aram, JA; Lodge, D; Martin, D; Millar, J; Pohler, G; Tomczyk, M; Zeman, S | 1 |
| Jope, RS; Li, X | 1 |
| Bengtsson, F; Siesjö, BK | 1 |
| Bennett, MV; Kushner, L; Lerma, J; Spray, DC; Zukin, RS | 1 |
| Cahill, GM; Menaker, M | 1 |
| Brooker, G; Costa, E; Danysz, W; Wroblewski, JT | 1 |
| Gallagher, JP; Lewis, MR; Phelan, KD; Shinnick-Gallagher, P | 1 |
| Chambers, JW; Deeter, JB; Huser, DL; Jones, ND; Leander, JD; Ornstein, PL; Paschal, JW; Schaus, JM; Wong, DT | 1 |
| Alho, H; Barbaccia, ML; Costa, E; Szekely, AM | 1 |
| Backus, KH; Kettenmann, H; Schachner, M | 1 |
| Fischbach, GD; Yang, J; Zorumski, CF | 1 |
| Harris, KM; Miller, RJ; Reynolds, IJ | 1 |
| Bourguignon, JP; Franchimont, P; Gérard, A | 1 |
| Deschenes, NL; Ransom, RW | 2 |
| Salt, TE | 1 |
| Hoffman, PL; Moses, F; Rabe, CS; Tabakoff, B | 1 |
| Kegerise, C; Noszek, JC; Siman, R | 1 |
| Balster, RL; Willetts, J | 3 |
| Costa, E; Fadda, E; Lazarewicz, JW; Mazzetta, J; Wroblewski, JT | 1 |
| Clark, GD; Clifford, DB; Thio, LL; Zorumski, CF | 1 |
| Choi, DW; Collins, RC; Dobkin, BH | 1 |
| Gonzales, RA; Moerschbaecher, JM | 1 |
| Bigge, CF; Brahce, LJ; Coughenour, LL; Drummond, JT; Johnson, G; Malone, T; Marcoux, FW; Probert, AW | 1 |
| Buerki, H; Fagg, GE; Mondadori, C; Petschke, F; Weiskrantz, L | 1 |
| Borosky, S; Ellenberger, SR; Ferkany, JW; Guzewska, ME; Jones, SM; Kyle, DJ; Rzeszotarski, WJ; Sacaan, AI; Snell, LD; Willets, J | 1 |
| Baron, BM; Dudley, MW; McCarty, DR; Miller, FP; Reynolds, IJ; Schmidt, CJ | 1 |
| Rao, TS; Wood, PL | 1 |
| Bourguignon, JP; Franchimont, P; Gerard, A; Mathieu, J; Simons, J | 1 |
| Ross, SM; Roy, DN; Spencer, PS | 1 |
| Cler, J; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Wood, PL | 1 |
| Amrick, CL; Bennett, DA; Bernard, PS; Hutchison, AJ; Liebman, JM; Wilson, DE | 1 |
| Ciliax, BJ; Gildersleeve, D; Pirat, JL; Van Dort, ME; Wieland, DM; Yang, DJ; Young, AB | 1 |
| Angst, C; Bernard, PS; Blanchard, L; de Jesus, R; Hutchison, AJ; Jackson, RH; Murphy, DE; Schneider, J; Williams, M; Wilusz, EJ | 1 |
| Haas, HL; Psarropoulou, C | 1 |
| Balázs, R; Cotman, CW; Hack, N; Jørgensen, OS | 1 |
| Iversen, SD; Oles, RJ; Preston, C; Singh, L; Tricklebank, MD | 1 |
| Araki, T; Kogure, K; Onodera, H | 1 |
| Dingledine, R; Kleckner, NW | 1 |
| Herberg, LJ; Rose, IC | 1 |
| Hillman, CC; Ornstein, PL; Salhoff, CR; Schoepp, DD | 1 |
| Iwasaki, M | 1 |
| Chow, C; McNamara, JO; Morrisett, RA; Nadler, JV | 1 |
| Brodin, L; Grillner, S; Hill, RH | 1 |
| Cotman, CW; Monaghan, DT; Palmer, E | 2 |
| Jope, RS; Ormandy, GC; Snead, OC | 1 |
| Ben-Ari, Y; Cherubini, E; Krnjević, K | 2 |
| Curran, T; Hempstead, J; Macgregor-Leon, PF; Mitchelmore, C; Morgan, JI; Sonnenberg, JL | 1 |
| Janssen, PA; Leysen, JE; Pauwels, PJ; Van Assouw, HP | 1 |
| Dingledine, R; Kleckner, NW; McBain, CJ; Wyrick, S | 1 |
| Molinoff, PB; Romano, C; Williams, K | 1 |
| Buckley, KS; Collins, GG | 1 |
| Krishtal, OA; Nowycky, MC; Petrov, AV; Smirnov, SV | 1 |
| Bartkowski, H; Roman, R; Simon, R | 1 |
| Ogita, K; Yoneda, Y | 6 |
| Barish, ME; Sands, SB | 1 |
| Miller, RJ; Reynolds, IJ | 1 |
| Billard, JM; Pumain, R | 1 |
| Anson, J; Collins, GG | 1 |
| Forti, L; Moran, O; Sciancalepore, M | 1 |
| Hershkowitz, N; Rogawski, MA | 1 |
| Kabuto, H; Mizukawa, K; Mori, A; Yokoi, I | 1 |
| Bergmann, F; Feigenbaum, JJ; Kloog, Y; Mechoulam, R; Nadler, V; Richmond, SA; Sokolovsky, M | 1 |
| de Montigny, C; Debonnel, G; Weiss, M | 1 |
| Deutsch, SI; Huntzinger, JA; Kaushik, M; Mastropaolo, J; Rosse, RB | 1 |
| Bonhaus, DW; McNamara, JO | 2 |
| Caspary, DM; Faingold, CL | 1 |
| Bauce, L; Kemp, DE; Weiss, S | 1 |
| Ito, I; Sugiyama, H; Watanabe, M | 1 |
| Carelli, RM; Jarvis, MF; Liebman, JM; O'Neill, KA | 1 |
| McCaslin, PP; Morgan, WW | 5 |
| Drejer, J; Honoré, T; Jensen, LH; Sheardown, MJ; Stidsen, CE | 1 |
| Leysen, JE; Pauwels, PJ; van Assouw, HP | 1 |
| Mundy, WR; Pediaditakis, P; Rogers, BC; Tilson, HA | 1 |
| Chambers, G; Cottrell, JE; Kass, IS | 1 |
| Haberly, LB; Hoffman, WH | 1 |
| Bergmann, D; Noble, EP; Sincini, E; ten Bruggencate, G | 1 |
| Dudek, S; Joly, M; Lynch, G; Muller, D; Schottler, F; Thibault, O | 1 |
| Fonnum, F; Syvertsen, C | 1 |
| Araneda, R; Bustos, G | 1 |
| Clow, DW; Jhamandas, K | 1 |
| Beal, MF; Ferrante, RJ; Kowall, NW; Martin, JB; Swartz, KJ | 1 |
| Girdlestone, D; Thomson, AM; West, DC | 1 |
| Dingledine, R; Kleckner, NW; Verdoorn, TA | 1 |
| Johnson, KM; Snell, LD | 5 |
| O'Dell, TJ | 1 |
| Chandler, SH | 1 |
| Kawai, N; Miwa, A; Nakajima, T; Sahara, Y; Saito, M; Shimazaki, K | 1 |
| Greenberg, JH; Karp, A; Reivich, M; Uematsu, D | 1 |
| Harris, KM; Miller, RJ | 2 |
| Westerberg, E; Wieloch, TW | 1 |
| Daly, MP; Demediuk, P; Faden, AI | 1 |
| Hablitz, JJ; Sutor, B | 1 |
| Miller, RJ; Murphy, SN | 1 |
| Guiramand, J; Nourigat, A; Recasens, M; Sassetti, I | 1 |
| Albers, GW; Choi, DW; Goldberg, MP | 1 |
| Blake, JF; Brown, MW; Collingridge, GL; Yates, RG | 1 |
| Oertel, D; Wickesberg, RE | 1 |
| D'Angio, M; Scatton, B; Serrano, A | 1 |
| Jahr, CE; Lester, RA; Parker, JD; Quarum, ML; Weber, E | 1 |
| Brugger, F; Olpe, HR; Pozza, MF; Steinmann, MW | 1 |
| Jackson, A; Sanger, DJ | 2 |
| Brewer, GJ; Cotman, CW | 1 |
| Demediuk, P; Faden, AI; Panter, SS; Vink, R | 1 |
| Meguri, H; Ogita, K; Ohgaki, T; Uchida, S; Yoneda, Y | 1 |
| Baba, A; Iwata, H; Kihara, T; Sawada, T | 1 |
| Pierson, MG; Smith, KL; Swann, JW | 1 |
| Chapman, B; Miller, KD; Stryker, MP | 1 |
| Beart, PM; Cincotta, M; Summers, RJ | 1 |
| King, AE; Thompson, SW | 1 |
| Bowen, DM; Hutson, PH; Lowe, SL; Palmer, AM | 1 |
| Costa, E; Favaron, M; Guidotti, A; Manev, H | 1 |
| Ben-Ari, Y; Represa, A; Tremblay, E | 1 |
| Crépel, F; Hicks, TP; Krupa, M | 1 |
| Akoev, GN; Andrianov, IuN; Bromm, B; Sabo, T; Sherman, NO | 1 |
| Guiramand, J; Recasens, M; Sassetti, I | 1 |
| Canonico, PL; Nicoletti, F | 1 |
| Choi, DW; Hartley, DM | 1 |
| Dun, NJ; Minota, S; Miyazaki, T; Read, HL; Wang, MY | 1 |
| Anderson, WW; Clark, S; Stasheff, SF; Wilson, WA | 1 |
| Belhage, B; Bouchelouche, P; Drejer, J; Frandsen, A; Schousboe, A | 1 |
| Caspary, DM; Faingold, CL; Hoffmann, WE | 1 |
| Astier, H; Tapia-Arancibia, L | 2 |
| Bowe, MA; Martin, D; Nadler, JV | 1 |
| Aizenman, E; Rosenberg, PA | 1 |
| Davidoff, RA; Hackman, JC; Zhang, DX | 1 |
| Gordon, FJ; Leone, C | 1 |
| Bekkers, JM; Stevens, CF | 1 |
| Beani, L; Bianchi, C; Jope, RS; Simonato, M | 1 |
| Calder, LD; Karler, R; Murphy, V; Turkanis, SA | 1 |
| Cunningham, JR; Neal, MJ | 2 |
| Herranz, AS; Herreras, O; Martín del Río, R; Menéndez, N; Solis, JM | 1 |
| Miyachi, E; Murakami, M | 1 |
| Gerber, G; Kangrga, I; Larew, JS; Randic, M; Ryu, PD | 1 |
| Dubinsky, JM; Rothman, SM; Yamada, KA | 1 |
| Anis, NA; Eldefrawi, AT; Eldefrawi, ME; Gant, DB; Konno, K; Miledi, R; Ragsdale, D | 1 |
| Busija, DW; Leffler, CW | 1 |
| Dildy, JE; Leslie, SW | 1 |
| Keith, RA; Klika, AB; Mangano, TJ; Meiners, BA; Patel, J; Salama, AI; Stumpo, RJ | 1 |
| Johnson, BG; Schoepp, DD | 1 |
| Sawyer, BD; Shannon, HE | 1 |
| Rakić, L; Shupliakov, OV; Supljakov, OV; Veskov, R; Vesselkin, NP | 1 |
| Bieger, D; Hashim, MA | 1 |
| Itzhak, Y | 1 |
| Dye, J; Heiligenberg, W; Kawasaki, M; Keller, CH | 1 |
| Bredt, DS; Snyder, SH | 1 |
| Bear, MF; Dudek, SM | 1 |
| Cooper, SM; Cotman, CW; Geddes, JW; Meldrum, BS; Patel, S | 1 |
| Benedetti, M; Frank, C; Sagratella, S; Scotti de Carolis, A | 1 |
| Moreau, JL; Pieri, L; Prud'hon, B | 1 |
| Keith, RA; Mangano, TJ; Salama, AI | 1 |
| Cherniack, NS; Mitra, J; Overholt, JL; Prabhakar, NR | 2 |
| Hornfeldt, CS; Larson, AA | 1 |
| Brunori, A; Mayer, ML; Sugiyama, K | 1 |
| Fink, K; Göthert, M | 1 |
| Bockaert, J; Didier, M; Piechaczyk, M; Pin, JP; Roux, P; Verrier, B | 1 |
| Smith, SS | 2 |
| Gallagher, JP; Hasuo, H | 1 |
| Avanzini, G; de Curtis, M; Spreafico, R | 1 |
| Simon, RP | 1 |
| Choi, DW; Goldberg, MP; Monyer, H; Tecoma, ES | 1 |
| Arenson, MS; Nistri, A | 1 |
| Mayer, ML; Westbrook, GL | 3 |
| Arenson, MS; King, A; Nistri, A | 1 |
| Ben-Ari, Y; Cherubini, E; Neuman, RS | 1 |
| Leander, JD | 1 |
| Halliwell, RF; Lambert, JJ; Peters, JA | 1 |
| Turski, WA | 1 |
| Lee, LR; Pohl, CR; Smith, MS | 1 |
| Arslan, M; Gay, VL; Marshall, GR; Plant, TM | 1 |
| Mogenson, GJ; Yim, CY | 1 |
| Dubuc, R; Grillner, S | 1 |
| Johnson, RF; Moore, RY; Morin, LP | 1 |
| Ben-Ari, Y; Cherubini, E; King, AE | 1 |
| France, CP; Ornstein, P; Woods, JH | 1 |
| Choi, DW; Tecoma, ES | 1 |
| Aryanpur, JJ; Cole, AE; Eccles, CU; Fisher, RS | 1 |
| Drejer, J; Honoré, T; Nielsen, EO; Sheardown, M | 1 |
| Buscher, W; Huston, JP; Schugens, M; Wagner, U | 1 |
| Jacobson, AE; Mattson, MV; Rice, KC; Rogawski, MA; Thurkauf, A; Yamaguchi, S | 1 |
| Boling, JA; Estienne, MJ; Green, MA; Hileman, SM; Schillo, KK | 1 |
| Cador, M; Everitt, BJ; Robbins, TW | 2 |
| Nunn, PB; O'Brien, P | 1 |
| Cusack, NJ; Stone, TW | 1 |
| Christenson, J; Franck, J; Grillner, S | 1 |
| Anderson, AC; Gean, PW; Shinnick-Gallagher, P | 1 |
| Ikonomidou, C; Labruyere, J; Mosinger, JL; Olney, JW; Salles, KS | 1 |
| Bingmann, D; Speckmann, EJ; Walden, J | 1 |
| DeLaPaz, R; Kunis, D; Saleh, J; Steinberg, GK; Zarnegar, SR | 2 |
| Beart, PM; Jarrott, B; Lewis, SJ; Louis, WJ; Robinson, TG; Verberne, AJ | 1 |
| Church, J; Davies, SN; Jones, MG; Lodge, D | 1 |
| Cotman, CW; Neal, JH; Peterson, C | 1 |
| McCulloch, J; Nehls, DG; Park, CK; Teasdale, GM | 1 |
| Friedemann, M; Gerhardt, GA | 1 |
| Barrington, M; Ehrlich, D; Sattayasai, J; Zappia, J | 1 |
| Chapman, AG; Meldrum, BS | 1 |
| de Carvalho, LP; Geoffroy, M; Lambolez, B; Rossier, J; Stinnakre, J | 1 |
| Jones, MW; Kilpatrick, IC; Phillipson, OT | 1 |
| Dun, NJ; Mo, N | 1 |
| Desban, M; Gauchy, C; Glowinski, J; Kemel, ML; Krebs, MO | 1 |
| Talman, WT | 1 |
| Johnston, MV; McDonald, JW; Silverstein, FS; Uckele, J | 1 |
| Haroutunian, V; Kanof, PD; Santucci, AC | 1 |
| Béloeil, JC; Champagnat, J; Fortin, G; Gillet, B; Jacquin, T; Pasquier, C | 2 |
| Jackson, BW; Lewin, AH; Marvizón, JC; Monn, JA; Rice, KC; Skolnick, P | 1 |
| Ellrén, K; Lehmann, A | 1 |
| Johnston, MV; McDonald, JW; Roeser, NF; Silverstein, FS | 1 |
| Boyce, S; Crossman, AR; Luquin, MR; Peggs, D; Sambrook, MA | 1 |
| Balster, RL; Bobelis, DJ; Willetts, J | 1 |
| Crawford, M; Roberts, PJ | 1 |
| Finger, S; Olney, JW; Stewart, GR; Wozniak, DF | 1 |
| Igarashi, H; Kamei, J; Kasuya, Y; Tanihara, H | 1 |
| Ishida, M; Ohfune, Y; Shimamoto, K; Shinozaki, H | 1 |
| Johnston, MV; McDonald, JW; Silverstein, FS; Uckele, JE | 1 |
| Aizenman, E; Lipton, SA; Loring, RH | 1 |
| Shreve, PE; Uretsky, NJ | 3 |
| Butelman, ER | 1 |
| DeNoble, VJ; Jones, KW; Schaeffer, CL | 1 |
| Darlington, CL; Smith, PF | 2 |
| Headley, PM; Parsons, CG; West, DC | 1 |
| Jarvis, MF; Murphy, DE; Williams, M | 1 |
| Grillner, S; Hill, RH; Moore, LE | 1 |
| Bustos, G; Rudolph, MI | 1 |
| Cheney, DL; Lehmann, J; McPherson, SE; Steel, D; Wood, PL | 1 |
| Frierdich, G; Labruyere, J; Mueller, M; Olney, JW; Price, MT; Salles, KS; Silverman, E | 1 |
| Jacobson, AE; Johnson, KM; Lessor, RA; Rice, KC; Snell, LD; Yi, SJ | 1 |
| Baudry, M; Kramer, K; Lynch, G; Muller, D; Vodyanoy, V | 1 |
| Carter, CJ; Noel, F; Scatton, B | 2 |
| Evans, MC; Meldrum, BS; Swan, JH | 1 |
| Amrick, CL; Bennett, DA; Bernard, PS | 1 |
| Johnson, KM; Nichtenhauser, R; Rivier, J; Samaan, H; Sircar, R; Snell, LD; Vale, W; Zukin, RS; Zukin, SR | 1 |
| Koch, C | 1 |
| Burton, NR; Stone, TW | 1 |
| Czuczwar, SJ; Janusz, W; Kleinrok, Z; Wamil, A | 1 |
| Aram, JA; Church, J; Davies, SN; Lodge, D; Martin, D; Millar, JD | 1 |
| Horn, G; McCabe, BJ | 1 |
| Haring, R; Kloog, Y; Sokolovsky, M | 1 |
| Johnson, KM; Snell, LD; Yi, SJ | 2 |
| Choi, DW; Koh, JY | 1 |
| Drejer, J; Honoré, T | 2 |
| Akaike, N; Hori, N; Kaneda, M; Krishtal, OA | 1 |
| Balázs, R; Hack, N; Jørgensen, OS | 2 |
| Champagnat, J; Denavit-Saubié, M; Foutz, AS | 2 |
| Choi, DW; Goldberg, MP; Viseskul, V | 1 |
| Koek, W; Winger, GD; Woods, JH | 1 |
| Pullan, LM | 1 |
| Grantyn, R; Lux, HD | 1 |
| Kauer, JA; Malenka, RC; Nicoll, RA | 2 |
| Arslan, M; Plant, TM; Pohl, CR | 1 |
| Faden, AI; Simon, RP | 1 |
| Carter, CJ; Gueugnon, J; Scatton, B | 1 |
| Aizenman, E; Karschin, A; Lipton, SA | 1 |
| Foster, AC; Iversen, LL; Kemp, JA; Leeson, PD; Priestley, T; Tridgett, R; Woodruff, GN | 1 |
| Costa, E; Lazarewicz, JW; Palmer, ME; Wroblewski, JT | 1 |
| Heinemann, U; Köhr, G | 1 |
| Burgoyne, RD; Cambray-Deakin, M; Pearce, IA | 1 |
| Klockgether, T; Lehmann, J; Schwarz, M; Sontag, KH; Turski, L | 1 |
| Birch, PJ; Grossman, CJ; Hayes, AG | 3 |
| Chapman, AG; Hutchison, A; Lehmann, J; Meldrum, BS; Tsai, C; Wood, PL | 1 |
| Lalies, M; Middlemiss, DN; Ransom, R | 1 |
| Lehmann, J; Schneider, JA; Tsai, C | 1 |
| Kater, SB; Mattson, MP | 1 |
| Bertin, J; Carter, C; Dupont, R; Duverger, D; Frost, J; Gaudilliere, B; Gotti, B; MacKenzie, ET; Rousseau, J; Scatton, B | 1 |
| Arbilla, S; Benavides, J; Carter, C; Legendre, P; Lloyd, KG; MacKenzie, ET; Noel, F; Thuret, F; Vincent, JD; Zivkovic, B | 1 |
| Chavkin, C; Malouf, AT; Swearengen, E | 1 |
| Costa, E; Danysz, W; Fadda, E; Wroblewski, JT | 1 |
| Hurt, SD; Hutchison, AJ; Murphy, DE; Sills, MA; Williams, M | 1 |
| Schmidt, CJ; Taylor, VL | 1 |
| Ciliax, BJ; Gildersleeve, DL; Kilbourn, MR; Laborde, E; Pirat, JL; Van Dort, ME; Wieland, DM; Yang, DJ; Young, AB | 1 |
| De Prins, E; Marrannes, R; Wauquier, A; Willems, R | 1 |
| Kawai, N; Ohsako, S; Saito, M | 1 |
| Jacquet, YF; Squires, RF | 1 |
| Jacquet, YF | 1 |
| Meldrum, BS; Millan, MH; Patel, S | 1 |
| Carter, C; Noel, F; Scatton, B | 1 |
| Loo, PS; Sills, MA; Williams, M | 1 |
| Lodge, D; Martin, D | 3 |
| Noszek, JC; Siman, R | 1 |
| Harrison, NL; Simmonds, MA | 1 |
| Bloomfield, SA; Dowling, JE | 1 |
| Collins, JF; Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Turski, WA | 1 |
| Galton, N; Michaelis, E; Roy, S | 1 |
| Beart, PM; Bridge, S; Christie, MJ; James, LB | 1 |
| Christensen, BN; Hals, G; Shingai, R | 1 |
| Collins, JF; Meldrum, BS; Turski, L | 1 |
| Harris, RA | 1 |
| Labruyere, J; Olney, JW; Price, MT; Samson, L | 1 |
| Cohen, A; Erez, U; Frenk, H; Goldberg, O; Teichberg, VI | 1 |
| Kimura, H; Okamoto, K; Sakai, Y | 1 |
| Jahr, CE; Jessell, TM | 1 |
| Meldrum, B; Schwarcz, R | 1 |
| Cotman, CW; Monaghan, DT; Yao, D | 1 |
| Gibson, BL; Reif-Lehrer, L | 1 |
| Homma, S | 1 |
| Gray, PN; May, PC | 1 |
| Cotman, CW; Monaghan, DT | 3 |
| Lukasiewicz, PD; McReynolds, JS | 1 |
| Goldberg, O; Teichberg, VI | 2 |
| Davies, J; Quinlan, JE | 1 |
| Baba, A; Iwata, H; Morimoto, H | 1 |
| Hagberg, H; Hamberger, A; Lehmann, A; Nyström, B; Sandberg, M | 1 |
| Murali Mohan, P; Sastry, BR | 1 |
| Brodin, L; Grillner, S | 1 |
| Cotman, CW; Ganong, AH | 1 |
| Hablitz, JJ | 2 |
| Martin, MR | 2 |
| Campochiaro, P; Coyle, JT; Ferkany, JW | 2 |
| Baudry, M; Cummins, JT; Kessler, M; Lynch, G; Way, S | 1 |
| Beart, PM; Christie, MJ; James, LB | 1 |
| Masui, H; Sato, H; Tsumoto, T | 1 |
| Thomson, AM | 2 |
| Curry, K; Magnuson, DS; McLennan, H; Peet, MJ | 2 |
| Canning, HM; Leach, MJ; Marden, CM | 1 |
| Collins, KJ; Wheatley, PL | 1 |
| Addae, JI; Stone, TW | 2 |
| Collins, JF; Stone, TW | 1 |
| Gregersen, H; McLennan, H; Peet, MJ | 1 |
| Ariel, M; Dowling, JE; Mangel, SC | 1 |
| Klockgether, T; Schwarz, M; Sontag, KH; Turski, L | 1 |
| Drejer, J; Honoré, T; Meier, E; Schousboe, A | 1 |
| Frenk, H; Liban, A; Teichberg, VI; Urca, G | 1 |
| Jürgens, U; Richter, K | 1 |
| Franchi-Micheli, S; Luzzi, S; Moroni, F; Zilletti, L | 1 |
| Gale, K; Piredda, S | 1 |
| Crepel, F; Gardette, R | 1 |
| Bobbin, RP; Jenison, GL; Winbery, S | 1 |
| Feldman, JL; McCrimmon, DR; Speck, DF | 1 |
| Koek, W; Ornstein, P; Woods, JH | 1 |
| Choi, DW; Koh, JY; Peters, S | 2 |
| Stone, TW | 3 |
| Davies, J; Evans, RH; Herrling, PL; Jones, AW; Olverman, HJ; Pook, P; Watkins, JC | 1 |
| Cotman, CW; Ganong, AH; Harris, EW; Monaghan, DT; Watkins, JC | 1 |
| Cotman, CW; Geddes, JW | 1 |
| Dragunow, M; Goddard, GV; Morimoto, K | 1 |
| De Belleroche, JS; Gardiner, IM; Hamilton, MH; Herberg, LJ | 1 |
| MacDonald, JF; Miljkovic, Z; Schneiderman, JH | 1 |
| King, AE; Nistri, A | 1 |
| D'Amato, CJ; Greenamyre, JT; Penney, JB; Young, AB | 1 |
| Costa, E; Nicoletti, F; Wroblewski, JT | 1 |
| Johnson, KM; Jones, SM; Snell, LD | 2 |
| Ballanyi, K; Endres, W; Grafe, P; Serve, G | 1 |
| Cotman, CW; Monaghan, DT; Westerberg, E; Wieloch, T | 1 |
| Gordon, FJ | 1 |
| Fagg, GE; Foster, AC | 1 |
| Anderson, WW; Swartzwelder, HS; Wilson, WA | 1 |
| Bennett, DA; Bernard, P; Boehm, C; Lehmann, J; McPherson, S; Murphy, DE; Pastor, G; Schneider, J; Steel, DJ; Tsai, C | 1 |
| Michel, J; Monahan, JB | 1 |
| Gustafsson, B; Wigström, H | 1 |
| Choi, DW; Koh, J; Peters, S | 1 |
| Ito, K; Izumi, Y; Kato, H; Kudo, Y; Miyakawa, H; Ogura, A | 1 |
| Davies, SW; Roberts, PJ | 1 |
| Anderton, PJ; Normann, RA; Perlman, I | 1 |
| Avoli, M; Olivier, A | 1 |
| Foster, AC; Wong, EH | 1 |
| Lehmann, A | 2 |
| Johnson, KM; Nichtenhauser, R; Rivier, J; Snell, LD; Vale, W; Zukin, RS; Zukin, SR | 1 |
| Crepel, F; Dupont, JL; Gardette, R | 2 |
| Compton, RP; Hood, WF; Michel, J; Monahan, JB; Olney, JW; Price, MT; Pullan, LM | 1 |
| Drejer, J; Honoré, T; Schousboe, A | 1 |
| Lees, GJ | 1 |
| Cherniack, NS; Deal, EC; Haxhiu, MA; Norcia, MP; Strohl, KP; van Lunteren, E | 1 |
| Crunelli, V; Kelly, JS; Leresche, N; Pirchio, M | 1 |
| de Carolis, AS; Frank, C; Sagratella, S | 1 |
| Morgan, IG | 1 |
| Durand, J; Engberg, I; Tyc-Dumont, S | 1 |
| Samanin, R; Vezzani, A; Wu, HQ | 1 |
| Bockaert, J; Kemp, DE; Schmidt, BH; Sebben, M; Sladeczek, F; Weiss, S | 1 |
| Cotman, CW; Harris, EW; Stevens, DR | 1 |
| Grantyn, R; Hablitz, JJ; Lux, HD; Perouansky, M | 1 |
| Burton, NR; Smith, DA; Stone, TW | 2 |
| Breese, GR; Givens, BS; McCown, TJ | 1 |
| Greenamyre, JT; Olson, JM; Penney, JB; Young, AB | 2 |
| Benavides, J; Carter, C; Fage, D; Scatton, B | 1 |
| Barry, MJ; O'Donovan, MJ | 1 |
| Alho, H; Costa, E; Eva, C; Fadda, E; Nicoletti, F; Wroblewski, JT | 1 |
| Frierdich, G; Labruyere, J; Mahan, K; Olney, JW; Price, MT; Ryerson, R; Salles, KS; Samson, L | 1 |
| Cuénod, M; Knöpfel, T; Zeise, ML; Zieglgänsberger, W | 1 |
| Crepel, F; Gardette, R; Krupa, M | 1 |
| Aram, JA; Lodge, D | 1 |
| Childs, AM; Evans, RH; Watkins, JC | 1 |
| Fischbach, GD; Thio, LL; Trussell, LO; Zorumski, CF | 2 |
| Burton, NR; Williams, TL | 1 |
| Dryer, SE | 1 |
| Caudle, RM; Isaac, L | 2 |
| Walker, JB; Woznicki, DT | 1 |
| Nishizaki, T; Okada, Y; Yamauchi, R | 1 |
| Beart, PM; Headley, PM; Nicolopoulos, LS; West, DC | 1 |
| Choi, DW; Coulter, DA; Prince, DA; Wong, BY | 1 |
| Engberg, I; Flatman, JA; Nedergaard, S | 2 |
| Ambar, I; Kloog, Y; Sokolovsky, M | 1 |
| Baba, A; Iwata, H; Nishiuchi, Y; Tatsuno, T; Uemura, A | 1 |
| Bockaert, J; Pin, JP; Van-Vliet, BJ | 1 |
| Sheardown, MJ | 1 |
| Connick, JH; Stone, TW | 1 |
| Carter, CJ; L'Heureux, R; Scatton, B | 1 |
| Hutchison, AJ; Lehmann, J; McPherson, SE; Mondadori, C; Murphy, DE; Schmutz, M; Sinton, CM; Steel, DJ; Tsai, C; Williams, M | 1 |
| Kaneko, A; Tachibana, M | 1 |
| Pastuszko, A; Wilson, DF | 1 |
| Davies, SN; Drejer, J; Fletcher, EJ; Honoré, T; Jacobsen, P; Lodge, D; Nielsen, FE | 1 |
| Nishizaki, T; Okada, Y | 1 |
| Lopes da Silva, FH; Melchers, BP; Pennartz, CM; Wadman, WJ | 1 |
| Lee, M; Strahlendorf, HK; Strahlendorf, JC | 1 |
| López-Colomé, AM; Roberts, PJ; Somohano, F | 1 |
| Aizenman, E; Hahn, JS; Lipton, SA | 1 |
| Fletcher, EJ; Lodge, D | 1 |
| Graham, DI; McCulloch, J; Nehls, DG; Park, CK; Teasdale, GM | 1 |
| Cuénod, M; Do, KQ; Herrling, PL; Streit, P | 1 |
| Canonico, PL; Catania, MV; Favit, A; Nicoletti, F | 1 |
| Dingledine, R; Verdoorn, TA | 1 |
| Boldry, RC; Uretsky, NJ | 1 |
| King, AE; Thompson, SW; Urban, L; Woolf, CJ | 1 |
| Mayer, ML; Vyklický, L; Westbrook, GL | 1 |
| Greuel, JM; Luhmann, HJ; Singer, W | 1 |
| Ben-Ari, Y; Charriaut-Marlangue, C; Represa, A; Roisin, MP; Tremblay, E | 1 |
| Choi, DW; Davenport, CJ; Monyer, H | 1 |
| Ben-Ari, Y; Cherubini, E; Gho, M; Neuman, RS | 1 |
| Beitz, AJ; Larson, AA | 1 |
| Lynch, G; Muller, D | 1 |
| Burton, NR; Smith, DA; Stone, TW; Williams, TL | 2 |
| Coleman, PA; Miller, RF | 1 |
| Foster, AC; Gill, R; Woodruff, GN | 1 |
| Cotman, CW; Monaghan, DT; Nguyen, L; Olverman, HJ; Watkins, JC | 1 |
| Arcavi, LJ; Ferriero, DM; McIntosh, TK; Sagar, SM; Simon, RP | 1 |
| Kapetanovic, IM; Kupferberg, HJ; Torchin, CD; Yonekawa, WD | 1 |
| Beart, PM; Davies, SN; Jones, MG; Lodge, D; Manallack, DT; Millar, J; Ornstein, PL; Verberne, AJ; Young, N | 1 |
| Linden, DJ; Routtenberg, A; Sheu, FS; Wong, KL | 1 |
| Davidoff, RA; Hackman, JC; Wohlberg, CJ | 1 |
| Davidson, N; Fong, TM; Lester, HA | 1 |
| Lauritzen, M; Nicholson, C; Okada, Y; Rice, ME | 1 |
| Baudry, M; Jung, MW; Larson, J; Lynch, G; Oliver, M; Seubert, P | 1 |
| Ben-Ari, Y; Corradetti, R; Gaïarsa, JL | 1 |
| Armstrong-James, M; Fox, K | 1 |
| Beart, PM; Bridge, S; Christie, MJ | 1 |
| Hankins, MW; Ruddock, KH | 1 |
| Farley, JM; Huang, HM; Jin, C; Rockhold, RW | 1 |
| Mogenson, GJ; Yang, CR | 1 |
| Grillner, S; Sigvardt, KA; Van Dongen, PA; Wallén, P | 1 |
| Berry, SC; Church, J; Lodge, D | 1 |
| Jones, AW; Meldrum, BS; Turski, L; Watkins, JC | 1 |
| Carroll, BL; Crowley, WR; Johnson, MD; Whetsell, WO | 1 |
| Wieloch, T | 1 |
| Anand, H; Badman, G; Collins, JF; Dixon, AJ; Roberts, PJ | 1 |
| Chu, DC; Greenamyre, JT; Maragos, WF; Penney, JB; Young, AB | 1 |
| Blake, J; Church, J; Davies, SN; Jacobson, AE; Lessor, RA; Lodge, D; Rice, KC | 1 |
| Cavalheiro, EA; Turski, L | 1 |
| Cavalheiro, EA; Meldrum, BS; Turski, L; Turski, WA | 1 |
| Nauta, HJ; Pisharodi, M | 1 |
| Dale, N | 1 |
| Dom, R; Ondo, JG | 1 |
| Meldrum, B | 1 |
| Herrling, PL; Klockgether, T; Sontag, KH; Turski, L; Watkins, JC | 1 |
| Davidoff, RA; Hackman, JC; Holohean, AM; Wohlberg, CJ | 1 |
| Drejer, J; Honoré, T; Nielsen, M; Olverman, HJ; Watkins, JC | 1 |
| Meldrum, BS; Turski, L; Turski, WA; Watkins, JC | 1 |
| Evans, RH; Evans, SJ; Pook, PC; Sunter, DC | 1 |
| Choi, DW; Peters, S; Viseskul, V | 1 |
| Kurcewicz, I; Louvel, J; Pumain, R | 2 |
| Choi, DW; Goldberg, MP; Kim, JP | 1 |
| Bury, D; Schmidt, WJ | 1 |
| Ho, PM; Tang, AH | 1 |
| Borosky, SA; Clissold, DB; Ferkany, JW; Pontecorvo, MJ | 1 |
| Cherubini, E; Herrling, PL; Lanfumey, L; Stanzione, P | 1 |
| Card, JP; Siman, R | 1 |
| Besharse, JC; Spratt, G | 1 |
| Nunez, AA; Sisk, CL; Thebert, MM | 1 |
| Faden, AI; Lemke, M; Noble, LJ; Simon, RP | 1 |
| Baskys, A; Carlen, PL; Reynolds, JN | 1 |
| Johnson, KM; Sacaan, AI; Snell, LD | 1 |
| Hönack, D; Löscher, W; Nolting, B | 1 |
| Dom, RM; Ondo, JG; Wheeler, DD | 1 |
| Gay, VL; Plant, TM | 2 |
| Consolo, S; Fisone, G; Tacconi, MT | 1 |
| Akaike, N; Carpenter, DO; Hori, N | 1 |
| Fukuda, H; Nagano, N; Ono, H | 1 |
| Fritze, J; Heinsen, H; Kornhuber, J; Retz, W; Riederer, P | 1 |
| Christensen, BN; O'Dell, TJ | 1 |
| Choi, DW; Viseskul, V | 1 |
| De Sarro, GB; Meldrum, BS; Patel, S | 1 |
| Beart, PM; Christie, MJ; Gibson, SJ; Louis, WJ; Papasava, M; Singer, G | 1 |
| McLarnon, JG; Quastel, DM | 1 |
| Jarrott, B; Lewis, SJ; Louis, WJ; Verberne, AJ | 1 |
| Fagni, L; Hugon, M; Zinebi, F | 2 |
| Ishimoto, I; Millar, TJ; Morgan, IG; Winder, C | 1 |
| Ransom, RW; Stec, NL | 1 |
| Hamon, B; Heinemann, U | 2 |
| Bell, RD; Cicero, TJ; Meyer, ER | 1 |
| Boast, CA; Etienne, PE; Gerhardt, SC; Lehmann, J; Liebman, JM; Pastor, G | 1 |
| Mutoh, N; Oosawa, K; Simon, MI | 1 |
| Bowery, NG; Hudson, AL; Wong, EH | 1 |
| Lawson, RR; Leander, JD; Ornstein, PL; Zimmerman, DM | 1 |
| Ebina, Y; Shingai, R | 1 |
| Kunis, D; Saleh, J; Steinberg, GK | 1 |
| Johnson, RF; Moore, RY; Morin, LP; Smale, L | 1 |
| Prasad, SK; Salt, TE; Wilson, DG | 1 |
| Beart, PM; Robinson, TG | 1 |
| Bunch, ST; Dunnett, SB; Jones, GH; Whishaw, IQ | 1 |
| Foster, AC; Gill, R; Kemp, JA; Woodruff, GN | 1 |
| Carpenter, DO; Galeno, T; Hori, N | 1 |
| Compton, RP; Contreras, PC; Monahan, JB; O'Donohue, TL | 1 |
| Ehrlich, D; Sattayasai, J | 1 |
| McNamara, JO; Scialabba, FA; Shin, C | 1 |
| Bonhaus, DW; McNamara, JO; Shin, C; Silver, JM | 1 |
| Do, KQ; Herrling, PL; Turski, WA | 1 |
| Church, J; Davies, SN; Lodge, D | 1 |
| Chapman, AG; Meldrum, BS; Nanji, N; Watkins, JC | 1 |
| Cherniack, NS; Deal, EC; Haxhiu, MA; Norcia, MP; van Lunteren, E | 1 |
| Howe, JR; Sutor, B; Zieglgänsberger, W | 1 |
| Ojeda, SR; Urbanski, HF | 1 |
| Boast, CA; Pastor, G | 1 |
| Frierdich, G; Labruyere, J; Olney, J; Price, M; Salles, KS | 1 |
| Lehmann, A; Zeise, M | 1 |
| Beart, PM; Christie, MJ; Jarrott, B; Lewis, SJ; Louis, WJ; Verberne, AJ; Worland, PJ | 1 |
| Garthwaite, G; Garthwaite, J; Yamini, B | 1 |
| Miller, RJ; Murphy, SN; Thayer, SA | 1 |
| Bohacek, R; ffRench-Mullen, JM; Fisher, RS; Lehmann, J | 1 |
| Liebman, JM; O'Neill, KA | 1 |
| Choi, DW; Kim, JP; Koh, JY | 1 |
| Blake, JC; Church, J; Davies, SN; Lodge, D; Martin, D | 1 |
| Faingold, CL; Meldrum, BS; Millan, MH | 1 |
| Beart, PM; Christie, MJ; Jarrott, B; Maccarrone, C | 1 |
| Agrawal, SG; Evans, RH | 1 |
| Cozzari, C; Hartman, BK; Olney, JW; Price, M; Stewart, GR | 1 |
| Henderson, G; Lacey, MG | 1 |
| Harrison, NL; Horne, AL; Simmonds, MA; Turner, JP | 1 |
| Carpenter, M; Fuller, TA; Labruyere, J; Mahan, K; Olney, JW; Price, MT; Samson, L | 1 |
| Garthwaite, G; Garthwaite, J; Hajós, F | 3 |
| Connick, JH; Heywood, GC; Smith, DA; Stone, TW | 1 |
| Hastings, MH; Herbert, J | 1 |
| Iversen, LL; Kemp, JA; Knight, AR; Priestley, T; Wong, EH; Woodruff, GN | 1 |
| Beart, PM; Christie, MJ; Rowe, PJ | 1 |
| Heinemann, U; Mody, I | 1 |
| Brady, RJ; Swann, JW | 1 |
| Ashton, D; Reid, K; Wauquier, A; Willems, R | 1 |
| Bonhaus, DW; McNamara, JO; Silver, JM | 1 |
| Bonhaus, DW; McNamara, JO; Shin, C | 1 |
| Hagberg, H; Hamberger, A; Jacobson, I; Lazarewicz, JW; Lehmann, A | 1 |
| Heinemann, U | 1 |
| Ben-Ari, Y; Cherubini, E; Gho, M; Rovira, C | 1 |
| Balm, M; Coyle, JT; Markl, A; Zaczek, R | 1 |
| Amrick, CL; Bennett, DA | 1 |
| Badura, LL; Brown, MH; Nunez, AA | 1 |
| De Kloet, ER; Joëls, M; Urban, IJ; Van Veldhuizen, M | 1 |
| Klockgether, T; Meldrum, BS; Schwarz, M; Sontag, KH; Turski, L | 1 |
| Bortolotto, ZA; Calderazzo-Filho, LS; Cavalheiro, EA; Ikonomidou-Turski, C; Meldrum, BS; Turski, L; Turski, WA | 1 |
| Inoue, F; Kanno, N; Sato, M; Sato, Y | 1 |
| Kudo, N; Yamada, T | 1 |
| Kato, S; Negishi, K; Teranishi, T | 1 |
| Czuczwar, SJ; Frey, HH; Löscher, W | 1 |
| Hastings, MH; Herbert, J; Roberts, AC | 1 |
| Farel, PB; McClellan, AD | 1 |
| Chapman, AG; Hart, GP; Meldrum, BS; Turski, L; Watkins, JC | 1 |
| Grillner, S; Wallén, P | 1 |
| Johnston, GA; Lodge, D | 1 |
| Pearson, RC; Sofroniew, MV | 1 |
| Lazarewicz, JW; Lehmann, A; Zeise, M | 1 |
| Biscoe, TJ; Burton, NR; Duchen, MR | 1 |
| Armstrong-James, M; Caan, AW; Fox, K | 1 |
| Peschanski, M; Ralston, HJ | 1 |
| Arbuthnott, GW; Garcia-Munoz, M; Hamilton, MH | 1 |
| Dunnett, SB; Hastings, MH; Winn, P | 1 |
| Rothman, SM | 1 |
| Berry, SC; Dawkins, SL; Lodge, D | 1 |
| Berry, SC; Church, J; Lai, HM; Lodge, D; Martin, D; McGhee, A; Thomson, AM | 1 |
| George, SR; Meissl, H | 1 |
| Davies, J; Francis, AA; Jones, AW; Watkins, JC | 1 |
| Evans, RH; Watkins, JC | 1 |
| Watkins, JC | 1 |
| Collins, JF; Curry, K; Perkins, MN; Stone, TW | 2 |
| Collins, JF; Curry, K; Labruyere, J; Olney, JW | 1 |
| Foster, GA; Roberts, PJ | 1 |
| Goldberg, O; Luini, A; Teichberg, VI | 3 |
| Hambley, JW; Rogers, LJ | 1 |
| Liu, J; McLennan, H | 1 |
| Mitchell, CK; Redburn, DA | 1 |
| Clarke, S; McFadden, PN | 1 |
| Collins, GG | 1 |
| Close, JM; Loewy, AD; Neil, JJ | 1 |
| Davies, J; Evans, RH; Jones, AW; Smith, DA; Watkins, JC | 1 |
| Evans, RH; Smith, DA | 1 |
| Lehmann, J; Scatton, B | 2 |
| Garthwaite, J | 1 |
| Bledsoe, SC; Bobbin, RP | 1 |
| Allan, RD; Bornstein, JC; Curtis, DR; Johnston, GA; Lodge, D | 1 |
| Eng, P; Hösli, E; Hösli, L; Lehmann, R | 1 |
| Berdichevsky, E; Orrego, F; Riveros, N; Sánchez-Armáss, S | 1 |
| Collingridge, GL; Kehl, SJ; McLennan, H | 1 |
| Miller, RF; Slaughter, MM | 1 |
| Dingledine, R | 2 |
| Olney, JW; Price, MT; Tal, J | 1 |
| Crunelli, V; Forda, S; Kelly, JS | 1 |
| Donzanti, BA; Uretsky, NJ | 3 |
| Collins, JF; Croucher, MJ; Curry, K; Czuczwar, SJ; Joseph, M; Meldrum, BS; Stone, TW | 1 |
| Kamp, CW; Morgan, WW | 1 |
| Collingridge, GL; Kehl, SJ; Loo, R; McLennan, H | 1 |
| Morán, J; Pasantes-Morales, H | 1 |
| Joëls, M; Urban, IJ | 2 |
| Ariel, M; Dowling, JE; Lasater, EM; Mangel, SC | 1 |
| Kerkut, GA; Mat Jais, AM; Sharma, RP; Walker, RJ | 1 |
| Agnati, LF; Celani, MF; Fuxe, K; Martire, M; Zini, I; Zoli, M | 1 |
| McLennan, H | 2 |
| Crepel, F; Dupont, JL; Fournier, E; Gardette, R | 1 |
| Anis, NA; Berry, SC; Lodge, D | 1 |
| Arenson, MS; Berti, C; King, AE; Nistri, A | 1 |
| Fagg, GE; Matus, A | 1 |
| Jackson, EA; Kelly, PH | 1 |
| Perkins, MN; Stone, TW | 6 |
| Coyle, JT; Ferkany, JW; Zaczek, R | 1 |
| Grillner, S; McClellan, A; Sigvardt, K; Wallén, P; Wilén, M | 1 |
| Czuczwar, SJ; Meldrum, B | 1 |
| Herrling, PL; Morris, R; Salt, TE | 1 |
| Cotman, CW; Ganong, AH; Lanthorn, TH | 1 |
| Anis, NA; Berry, SC; Burton, NR; Lodge, D | 2 |
| Dale, N; Roberts, A | 1 |
| Burgal, M; Grisolía, S; Jordá, A; Lizondo, J | 1 |
| Berg, HC; Block, SM; Segall, JE | 1 |
| Crill, WE; Flatman, JA; Schwindt, PC; Stafstrom, CE | 1 |
| Hubert, E; Iriarte, A; Kraft, K; Martinez-Carrion, M | 1 |
| Croucher, MJ; De Sarro, GB; Meldrum, BS | 1 |
| Crunelli, V; Mayer, ML | 1 |
| Jones, AW; Smith, DA; Watkins, JC | 1 |
| Hagberg, H; Hamberger, A; Lehmann, A | 1 |
| Arenas-Diaz, G; Martínez-Murillo, R; Martínez-Rodriguez, R | 1 |
| Badger, TM; Levenson, SE; Martin, JB; Millard, WJ; Rosenblum, PM | 1 |
| Crepel, F; Dhanjal, SS; Sears, TA | 1 |
| Collins, JF; Perkins, MN; Stone, TW | 1 |
| Dawbarn, D; Pycock, CJ | 1 |
| Knobil, E; Wilson, RC | 1 |
| Kerwin, RW; Luscombe, GP; Pycock, CJ; Sverakova, K | 1 |
| Buckel, W | 1 |
| Davies, J; Evans, RH; Francis, AA; Jones, AW; Watkins, JC | 1 |
| Johnston, GA; Skerritt, JH | 1 |
| MacDonald, JF; Wojtowicz, JM | 1 |
| Kochkina, VM; Makarov, VL; Torchinsky, YM | 1 |
| Collins, J; Coyle, JT; Zaczek, R | 1 |
| Silver, A | 1 |
| Anis, NA; Lodge, D | 1 |
| Evans, RH; Francis, AA; Jones, AW; Smith, DA; Watkins, JC | 1 |
| Goldberg, O; Luini, A; Tal, N; Teichberg, VI | 1 |
| Anis, NA; Burton, NR; Lodge, D | 1 |
| Botscheller, ML; DeKosky, ST; Marion, DW; Palmer, AM; Styren, SD; Swedlow, PE | 1 |
| Mikuni, M; Saitoh, K; Shinno, H; Takahashi, K; Tomita, U; Yamawaki, S | 1 |
| Beart, PM; Jones, NM; Loiacono, RE | 1 |
| Decelle, T; Henrotte, JG; Teste, JF | 1 |
| Bowen, DM; Dijk, SN; Francis, PT; Stratmann, GC | 1 |
| Cassaday, HJ; Feldon, J; Rawlins, JN; Tai, CT | 1 |
| Bustos, G; Gajardo, MI; Jerez, S; Labarca, R; Ruiz, A; Seguel, M; Silva, H | 1 |
| Büsselberg, D; Michael, D; Platt, B | 1 |
| Boulu, RG; Buisson, A; Callebert, J; Margaill, I; Plotkine, M | 1 |
| Barrionuevo, G; Fleck, MW; Henze, DA; Palmer, AM | 1 |
| López-Colomé, AM; Ortega, A; Romo-de-Vivar, M | 1 |
| Bonanno, G; Donadini, F; Fedele, E; Fontana, G; Raiteri, M; Vallebuona, F | 1 |
| Budelmann, BU; Tu, Y | 1 |
| Chandlee, JM; Lo, YH; Pang, J; Rhoads, DE | 1 |
| Hansen, L; Suzdak, PD; Thomsen, C | 1 |
| Burlina, AB; Burlina, AP; Ferrari, V; Leon, A; Mazza, MR; Skaper, SD | 1 |
| Bradford, HF; Young, AM | 1 |
| Sluka, KA; Westlund, KN | 1 |
| Battistin, L; Dam, M; Freo, U; Pietrini, P; Pizzolato, G; Soncrant, TT | 1 |
| Haas, HL; Sharonova, IN; Vorobjev, VS; Walsh, IB | 1 |
| Fisone, G; Greengard, P; Gundersen, V; Hökfelt, T; Morino, P; Ottersen, OP; Snyder, GL | 1 |
| Biggs, CS; Getting, SJ; Segieth, J; Whitton, PS | 1 |
| Armstrong, JD; Barb, CR; Campbell, RM; Cox, NM | 1 |
| Downing, JA; Joss, J; Scaramuzzi, RJ | 1 |
| Connor, JA; Curran, T; Forrest, D; Yuzaki, M | 1 |
| Haas, HL; Sharonova, IN; Skrebitsky, V; Vorobjev, VS | 1 |
| Kaneko, A; Sasaki, T | 1 |
| Crepel, F; Renard, A | 1 |
| Carter, C; Fage, D; Klarica, M | 1 |
| Ando, H; Kagawa, H; Sakube, Y | 1 |
| Carvalho, AP; Duarte, CB; Santos, PF | 1 |
| Budziszewska, B; Jaworska-Feil, L; Lasoń, W; Leśkiewicz, M; Siwanowicz, J | 1 |
| de Mello, FG; de Mello, MC; Kubrusly, RC | 1 |
| Chappell, RL; Schuette, E | 1 |
| Salter, MW; Yu, XM | 1 |
| D'Hooge, R; De Deyn, PP; Raes, A; Van Bogaert, PP; Van de Vijver, G | 1 |
| Irić-Cupić, V; Janković, SM; Matović, M; Milovanović, D | 1 |
| Juhász, G; Kardos, J; Kovács, I; Nyitrai, G; Skuban, N; Szárics, E | 1 |
| Delay, ER; Roper, SD; Stapleton, JR | 1 |
| Benz, A; Isenberg, KE; Krause, JE; Mennerick, S; Shen, W; Shimamoto, K; Tanaka, K; Xu, W; Zorumski, CF | 1 |
| Anderson, KJ; Burchfield, DJ; Mason, KL; McGraw, TS; Sapper, MS; Theophilopoulos, DT | 1 |
| Trussell, LO; Turecek, R | 1 |
| D'Aniello, A; D'Aniello, S; Di Fiore, MM; Fisher, GH; Ingrosso, D; Milone, A; Perna, AF; Seleni, A | 1 |
| Gähwiler, BH; Gerber, U; Jabaudon, D; Scanziani, M | 1 |
| Adamchik, Y; Baskys, A | 1 |
| D'Aniello, A; D'Aniello, G; Di Fiore, MM; Errico, F; Fisher, GH; Tolino, A | 1 |
| Brundin, P; Hansson, O; Haraldsson, B; Nicniocaill, B; O'Connor, WT | 1 |
| Feligioni, M; Pattarini, R; Pittaluga, A; Raiteri, M | 1 |
| Ito, S; Matsumura, S; Minami, T; Mishina, M; Mori, H; Okuda-Ashitaka, E; Sakimura, K; Shimamoto, K | 1 |
| Gentry, LR; Sticker, LS; Thompson, DL | 1 |
| Onishchenko, NV; Petrov, VI; Sergeyev, VS | 1 |
| Nguyen-Duong, H | 1 |
| Schoppa, NE; Westbrook, GL | 1 |
| Gafurov, B; Grossfeld, RM; Lieberman, EM; Urazaev, AK | 1 |
| Kawamoto, S; Kera, Y; Shibata, K; Takahashi, S; Tarui, A; Todoroki, N; Yamada, R | 1 |
| Calaza, KC; de Mello, FG; Gardino, PF | 1 |
| Dohovics, R; Hermann, A; Janáky, R; Oja, SS; Saransaari, P | 1 |
| Bachelard, HS; Badar-Goffer, RS; Ben-Yoseph, O; McLean, MA; Morris, PG; Prior, MJ; Taylor, A; Thatcher, NM | 1 |
| Chatterjee, SS; Davies, JA; Jones, FA | 1 |
| Bert, L; Denoroy, L; Desvignes, C; Parrot, S; Renaud, B; Robert, F; Suaud-Chagny, MF | 1 |
| Lefebvre, RA; Timmermans, JP; Van Geldre, LA | 1 |
| Hayashi, H; Hirotsu, K; Kagamiyama, H; Miyahara, I; Mizuguchi, H; Nakajima, Y | 1 |
| Bert, L; Denoroy, L; Parrot, S; Renaud, B | 1 |
| Barra, HS; Casale, CH; Previtali, G | 1 |
| Bordey, A; Sontheimer, H | 1 |
| Ahmed, Z; Baker, D; Croxford, JL; Cuzner, ML; Giovannoni, G; Hankey, DJ; Jackson, SJ; Ledent, C; Petzold, A; Pocock, JM; Pryce, G; Thompson, AJ | 1 |
| CRAWFORD, JM; CURTIS, DR | 1 |
| Baba, A; Ikegaya, Y; Matsuki, N; Mitsumori, K; Nishiyama, N; Yamada, MK | 1 |
| Aniello, F; Branno, M; D'Aniello, A; D'Aniello, S; De Simone, A; Di Fiore, MM; Fisher, GH; Rastogi, RK; Spinelli, P | 1 |
| Calaza, Kda C; de Mello, FG; de Mello, MC; Gardino, PF | 1 |
| Aniksztejn, L; Becq, H; Ben-Ari, Y; Demarque, M; Manent, JB; Represa, A; Villeneuve, N | 1 |
| Alonso, TJ; Castro Fuentes, R; García Dopico, J; González Hernández, T; Perdomo Díaz, J; Rodríguez Díaz, M | 1 |
| Delay, ER; Roper, SD; Sewczak, GM; Stapleton, JR | 1 |
| Grebenyuk, S; Kirichok, Y; Krishtal, O; Lozovaya, N; Melnik, S; Tsintsadze, T | 1 |
| Lee, YJ; Tsai, LH; Wu, JY | 1 |
| Auberson, YP; Bashir, ZI; Brown, MW; Collingridge, GL; Johnson, BE; Massey, PV; Molnar, E; Moult, PR | 1 |
| Guy, Y; Jilderos, B; Sandberg, M; Stridh, MH; Tranberg, M; Weber, SG; Wigström, H | 1 |
| Gebhardt, C; Heinemann, U; Iserhot, C; Schmitz, D | 1 |
| Bringmann, A; Klaus, C; Reichenbach, A; Rillich, K; Syková, E; Uckermann, O; Ulbricht, E; Vargová, L; Weick, M; Wiedemann, P | 1 |
| Goto, M; Hayashi, H; Hirotsu, K; Ikushiro, H; Islam, MM; Miyahara, I | 1 |
| Baldridge, WH; Chauhan, BC; Hartwick, AT; Zhang, X | 1 |
| Boeck, CR; Bronzatto, MJ; Jardim, FM; Kroth, EH; Souza, DO; Vendite, D | 1 |
| Dunlop, J; Foster, AC; Mackay, KB; Moyer, J; Naeve, GS; Nottebaum, LM; Petroski, RE; Pomeroy, JE; Selkirk, JV; Stiefel, TH; Vana, AM; Verge, GM | 1 |
| Albrieux, M; Boisseau, S; Brocard, J; Dupuis, A; Platel, JC; Poupard, A; Savasta, M; Villaz, M | 1 |
| Boder, E; Derr, P; Goulian, M | 1 |
| Bialek, M; Junemann, A; Kocki, T; Rejdak, R; Turski, WA; Zagorski, Z; Zarnowski, T; Zrenner, E | 1 |
| Kirchhoff, F; Lalo, U; North, RA; Pankratov, Y; Verkhratsky, A | 1 |
| Abbott, C; Bustillo, J | 1 |
| Coyle, JT; Frye, MA; Huggins, T; Post, RM; Tsai, GE | 1 |
| Cheng Liu, M; Gold, MS; Hayes, RL; Kobeissy, FH; Larner, SF; Wang, KK; Warren, MW; Zheng, W | 1 |
| Alehan, F; Erol, I; Melek, E; Muhteşem Ağildere, A; Ozyer, U | 1 |
| Horiike, K; Ishida, T; Tanaka, H; Yamamoto, A | 1 |
| Sandberg, M; Tranberg, M | 1 |
| Abbas, AK; Sandberg, M; Tranberg, M | 1 |
| Boeck, CR; Bronzatto, MJ; Kroth, EH; Vendite, D | 1 |
| Luccini, E; Musante, V; Neri, E; Pittaluga, A; Raiteri, M | 1 |
| Decker, H; Molz, S; Tasca, CI; Tharine, DC | 1 |
| Calaza, Kda C; Miya, VS; Paes-de-Carvalho, R; Portugal, CC; Santos, RA | 1 |
| Hare, WA; Wheeler, L | 1 |
| Bak, LK; Ring, A; Schousboe, A; Sonnewald, U; Waagepetersen, HS; Walls, AB | 1 |
| Blankenship, AG; Copenhagen, DR; Edwards, RH; Feller, MB; Ford, KJ; Johnson, J; Seal, RP | 1 |
| Risso, JJ; Rostain, JC; Vallee, N | 1 |
| Cunha, RA; Musante, V; Pittaluga, A; Raiteri, M; Summa, M | 1 |
| Carter, AG; Chalifoux, JR | 1 |
| Chen, JP; Hsu, KS; Huang, CC; Yeh, CM | 1 |
| Cao, Z; Hagerman, PJ; Hagerman, RJ; Hulsizer, S; Pessah, IN; Rogawski, MA; Tang, HT; Tassone, F | 1 |
| Deng, N; He, Z; Jiang, L; Luo, C; Ouyang, Q; Si, G; Tu, Y; Wu, T; Zhu, X | 1 |
| Averna, M; Cervetto, C; Frattaroli, D; Marcoli, M; Maura, G; Melloni, E; Patrone, M; Pedrazzi, M; Pontremoli, S; Salamino, F; Sparatore, B | 1 |
| Bertolino, A; Blasi, G; D'Aniello, A; de Bartolomeis, A; Errico, F; Napolitano, F; Squillace, M; Usiello, A; Vitucci, D | 1 |
| Miyake, S; Ozawa, Y; Tsubota, K; Yoshida, T; Yuki, K | 1 |
| Alaux-Cantin, S; Antol, J; Fedorenko, O; Kervern, M; Naassila, M; Pierrefiche, O; Silvestre de Ferron, B | 1 |
| Agostinho, P; Banerjee, S; Boddeke, HW; Cunha, RA; Matos, M; Moidunny, S; Roy, S; Volsky, DJ; Wesseling, E | 1 |
| Chiu, DN; Jahr, CE | 1 |
| Amoresano, A; Errico, F; Fontanarosa, C; Pane, F; Pinto, G; Pucci, P; Sepe, N; Squillace, M; Trifuoggi, M; Usiello, A | 1 |
| Attwell, D; Bazargani, N; Jolly, S; Li, H; Pringle, NP; Quiroga, AC; Richardson, WD | 1 |
| Hosseini-Zare, MS; Hübel, N; Ullah, G; Žiburkus, J | 1 |
| Barygin, OI; Dron, MY; Zhigulin, AS | 1 |
| Abushik, P; Ermakova, E; Gafurov, O; Giniatullin, R; Guerrero-Toro, C; Koroleva, K; Sitdikova, G; Tavi, P | 1 |
27 review(s) available for aspartic acid and n-methylaspartate
| Article | Year |
|---|---|
Interactions between glutamatergic and monoaminergic systems within the basal ganglia--implications for schizophrenia and Parkinson's disease.
Topics: Animals; Anticonvulsants; Aspartic Acid; Basal Ganglia; Biogenic Amines; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Humans; N-Methylaspartate; Parkinson Disease; Schizophrenia | 1990 |
Potential therapeutic uses of N-methyl-D-aspartate antagonists in cerebral ischemia.
Topics: Aspartic Acid; Brain Ischemia; Glutamates; Glutamic Acid; Humans; Models, Biological; N-Methylaspartate; Nervous System; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Formation of 12-lipoxygenase metabolites in rat cerebral cortical slices: stimulation by calcium ionophore, glutamate and N-methyl-D-aspartate.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonate 12-Lipoxygenase; Arachidonate Lipoxygenases; Aspartic Acid; Calcimycin; Cerebral Cortex; Glutamates; Glutamic Acid; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Agents; Phorbol Esters | 1990 |
Cerebral hypoxia: some new approaches and unanswered questions.
Topics: Animals; Aspartic Acid; Brain Diseases; Cell Survival; Cerebrovascular Circulation; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Hypoxia; N-Methylaspartate; Neuroglia; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Quinoxalinediones as excitatory amino acid antagonists in the vertebrate central nervous system.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Binding, Competitive; Central Nervous System; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Membrane Potentials; N-Methylaspartate; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Signal Transduction; Spinal Cord; Structure-Activity Relationship; Vertebrates | 1990 |
Activity-dependent tuning and the NMDA receptor.
Topics: Animals; Aspartic Acid; N-Methylaspartate; Neuronal Plasticity; Ranidae; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells; Superior Colliculi; Visual Pathways | 1990 |
Neuropharmacology of phencyclidine: basic mechanisms and therapeutic potential.
Topics: Animals; Aspartic Acid; Humans; N-Methylaspartate; Nervous System; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1990 |
Anticonvulsant actions of phencyclidine receptor ligands: correlation with N-methylaspartate antagonism in vivo.
Topics: Animals; Anticonvulsants; Aspartic Acid; Humans; Ligands; N-Methylaspartate; Phencyclidine | 1990 |
[Excitatory amino acid and their involvement in pathological processes in the brain].
Topics: Animals; Aspartic Acid; Brain Diseases; gamma-Aminobutyric Acid; Humans; N-Methylaspartate | 1990 |
Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis.
Topics: Aspartic Acid; Biological Transport, Active; Brain; Brain Ischemia; Calcium; Calcium Channels; Cell Membrane; Cell Survival; Glutamates; Homeostasis; Humans; Hypoglycemia; N-Methylaspartate; Neurons; Potassium; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Selective vulnerability of the brain: new insights into the pathophysiology of stroke.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Cell Survival; Glutamates; Humans; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission | 1989 |
The role of excitatory amino acids and intraneuronal calcium in the acute intoxicational effects of ethanol.
Topics: Alcoholic Intoxication; Amino Acids; Animals; Aspartic Acid; Calcium; Calcium Channels; Humans; N-Methylaspartate; Neurons; Synaptic Transmission | 1989 |
TCP binding: a tool for studying NMDA receptor-mediated neurotransmission in kindling.
Topics: Animals; Aspartic Acid; Brain; Glycine; Kindling, Neurologic; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia?
Topics: Aspartic Acid; Brain; Brain Ischemia; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Models, Neurological; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1989 |
Role of endogenous excitatory amino acid neurotransmitters in the pathogenesis and evolution of acute brain injury.
Topics: Acute Disease; Amino Acids; Animals; Aspartic Acid; Brain Diseases; Brain Injuries; Calcium; Calcium Channels; Humans; Meningitis; N-Methylaspartate; Neurotransmitter Agents; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
The action of the corticofugal pathway on sensory thalamic nuclei: a hypothesis.
Topics: Animals; Aspartic Acid; Geniculate Bodies; Mammals; N-Methylaspartate; Neural Pathways; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Thalamic Nuclei; Visual Cortex | 1987 |
NMDA receptors and ligands in the vertebrate CNS.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Behavior, Animal; Binding, Competitive; Central Nervous System; Evoked Potentials; Kinetics; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1988 |
In vivo regulation of extracellular taurine and other neuroactive amino acids in the rabbit hippocampus.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Ethanolamines; Extracellular Space; Hippocampus; Iodoacetates; Iodoacetic Acid; Ischemia; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Potassium; Rabbits; Taurine | 1985 |
Excitatory amino acid transmitters in neuronal circuits of the cat visual cortex.
Topics: Acetylcholine; Animals; Aspartic Acid; Cats; Dipeptides; Evoked Potentials, Visual; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Neurons; Neurotransmitter Agents; Pipecolic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Visual Cortex | 1986 |
The physiology of excitatory amino acids in the vertebrate central nervous system.
Topics: Amino Acids; Animals; Aspartic Acid; Central Nervous System; Glutamates; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Vertebrates | 1987 |
Excitatory receptors and their role in excitotoxicity.
Topics: Aminobutyrates; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Humans; N-Methylaspartate; Neurons; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
On the excitatory post-synaptic potential evoked by stimulation of the optic tract in the rat lateral geniculate nucleus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aminobutyrates; Animals; Aspartic Acid; Calcium; Dipeptides; Glutamates; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Optic Nerve; Rats; Rats, Inbred Strains; Synapses; Thalamic Nuclei; Valine | 1987 |
Release of neuroactive substances: homocysteic acid as an endogenous agonist of the NMDA receptor.
Topics: Animals; Aspartic Acid; Brain; Chromatography, High Pressure Liquid; Cysteine; Homocysteine; N-Methylaspartate; Neurotransmitter Agents; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tissue Distribution | 1988 |
Baclofen reduces post-synaptic potentials of rat cortical neurones by an action other than its hyperpolarizing action.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Baclofen; Bicuculline; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; N-Methylaspartate; Neurons; Potassium; Rats; Rats, Inbred Strains; Stereoisomerism; Synapses; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors | 1987 |
Pharmacology of excitatory amino acid transmitters.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate | 1981 |
The stimulation of ion fluxes in brain slices by glutamate and other excitatory amino acids.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Brain; Calcium; Cations; Cell Membrane Permeability; Glutamates; Glutamic Acid; In Vitro Techniques; Ion Channels; Kainic Acid; Kinetics; N-Methylaspartate; Potassium; Rubidium; Sodium; Sodium-Potassium-Exchanging ATPase | 1981 |
What have we learned from proton magnetic resonance spectroscopy about schizophrenia? A critical update.
Topics: Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Cross-Over Studies; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; N-Methylaspartate; Neurons; Protons; Schizophrenia; Temporal Lobe | 2006 |
2 trial(s) available for aspartic acid and n-methylaspartate
| Article | Year |
|---|---|
N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia?
Topics: Aspartic Acid; Brain; Brain Ischemia; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Models, Neurological; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1989 |
Aspartate and glutamate modulation of growth hormone secretion in the pig: possible site of action.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Aspartic Acid; Body Weight; Cells, Cultured; Dose-Response Relationship, Drug; Female; Glutamic Acid; Growth Hormone; Growth Hormone-Releasing Hormone; N-Methylaspartate; Ovariectomy; Pituitary Gland, Anterior; Serum Albumin; Swine | 1996 |
1104 other study(ies) available for aspartic acid and n-methylaspartate
| Article | Year |
|---|---|
DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy.
Topics: Animals; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Molecular Structure; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tetrazoles | 1992 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Excitatory amino acid receptors and synaptic excitation in the mammalian central nervous system.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Glutamates; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Neurotransmitter; Spinal Nerve Roots | 1979 |
The cortical lesion of Huntington's disease: further neurochemical characterization, and reproduction of some of the histological and neurochemical features by N-methyl-D-aspartate lesions of rat cortex.
Topics: Age Factors; Aged; Animals; Aspartic Acid; Brain Chemistry; Cholecystokinin; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Humans; Huntington Disease; Male; Middle Aged; N-Methylaspartate; Neurochemistry; Rats; Rats, Sprague-Dawley; Somatostatin; Substance P | 1992 |
Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture.
Topics: Animals; Aspartic Acid; Astrocytes; Biological Transport; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; N-Methylaspartate; Rats; Sodium; Stereoisomerism | 1992 |
Effects of ovarian steroids on the gonadotropin response to N-methyl-D-aspartate and on hypothalamic excitatory amino acid levels during sexual maturation in female rats.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Estrogens; Female; Follicle Stimulating Hormone; Glutamates; Glutamic Acid; Glycine; Gonadotropin-Releasing Hormone; Gonadotropins; Hypothalamus; Luteinizing Hormone; N-Methylaspartate; Ovary; Preoptic Area; Progesterone; Rats; Rats, Inbred Strains; Sexual Maturation | 1992 |
Selective potentiation of NMDA-induced activity and release of excitatory amino acids by dynorphin: possible roles in paralysis and neurotoxicity.
Topics: Animals; Aspartic Acid; Behavior, Animal; Cell Death; Dizocilpine Maleate; Dynorphins; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurons; Paralysis; Rats; Rats, Inbred Strains; Spinal Cord | 1992 |
Interaction between thyrotropin-releasing hormone (TRH) and NMDA-receptor-mediated responses in hypoglossal motoneurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Brain Stem; Evoked Potentials; Glutamates; Glutamic Acid; Guinea Pigs; Hypoglossal Nerve; In Vitro Techniques; Membrane Potentials; Motor Neurons; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Synapses; Tetrodotoxin; Thyrotropin-Releasing Hormone | 1992 |
Regulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum: in vivo microdialysis studies.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Extracellular Space; Fluorometry; Glutamates; Glutamic Acid; Kynurenic Acid; Male; N-Methylaspartate; Perfusion; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
N-methyl-D-aspartate exposure blocks glutamate toxicity in cultured cerebellar granule cells.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Culture Media; Cytoplasmic Granules; Excitatory Amino Acid Antagonists; Glucose; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Ouabain; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sensitivity and Specificity; Tritium | 1992 |
The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801.
Topics: Animals; Aspartic Acid; Culture Techniques; Deoxyglucose; Dizocilpine Maleate; Glucose; Glutamates; Glutamic Acid; Hippocampus; Histological Techniques; Hypoglycemia; N-Methylaspartate; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Time Factors | 1992 |
A highly potent and selective N-methyl-D-aspartate receptor antagonist from the venom of the Agelenopsis aperta spider.
Topics: Agatoxins; Animals; Aspartic Acid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neurotoxins; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spiders | 1992 |
Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat.
Topics: Action Potentials; Animals; Animals, Newborn; Aspartic Acid; Brain Stem; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Locomotion; N-Methylaspartate; Nerve Net; Quisqualic Acid; Rats; Rats, Wistar; Serotonin; Spinal Cord | 1992 |
N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. I. Location on axon terminals and pharmacological characterization.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Axons; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptosomes | 1992 |
Potentiation of NMDA receptor currents by arachidonic acid.
Topics: Animals; Arachidonic Acid; Aspartic Acid; Calcium; Cerebellum; Drug Synergism; Electric Conductivity; Glutamates; Glutamic Acid; Ion Channel Gating; Ion Channels; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems | 1992 |
Excitatory amino acid receptors on isolated retinal ganglion cells from the goldfish.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cells, Cultured; Chlorides; Electrophysiology; Glutamates; Glutamic Acid; Goldfish; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Retinal Ganglion Cells; Sodium | 1992 |
NMDA-induced release of nitric oxide potentiates aspartate overflow from cerebellar slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine; Aspartic Acid; Cerebellum; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Magnesium; N-Methylaspartate; Nitric Oxide; omega-N-Methylarginine; Quisqualic Acid; Rats; Rats, Wistar | 1992 |
Thyrotropin releasing hormone (TRH) and its analog, RGH-2202, accelerate maturation of cerebellar neurons in vitro.
Topics: Analysis of Variance; Animals; Aspartic Acid; Biological Transport; Calcium; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Inositol Phosphates; Kinetics; N-Methylaspartate; Neurons; Rats; Thyrotropin-Releasing Hormone | 1992 |
Quantitative autoradiographic analysis of excitatory amino acid receptors in the cat spinal cord.
Topics: Animals; Aspartic Acid; Autoradiography; Cats; Kainic Acid; N-Methylaspartate; Receptors, Amino Acid; Receptors, Cell Surface; Sodium; Spinal Cord | 1991 |
Acetylcholine release from the rabbit retina mediated by kainate receptors.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Choline; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Rabbits; Receptors, Kainic Acid; Receptors, Neurotransmitter; Retina | 1991 |
Neurochemical characterization of excitotoxin lesions in the cerebral cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Homocysteine; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; NADPH Dehydrogenase; Neuropeptides; Neurotoxins; Neurotransmitter Agents; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
NMDA receptor agonists selectively block N-type calcium channels in hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Aspartic Acid; Calcium; Calcium Channels; Glutamates; Hippocampus; Kynurenic Acid; Mollusk Venoms; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1991 |
Glutamate and aspartate immunoreactivity in hypothalamic presynaptic axons.
Topics: Animals; Antibody Specificity; Aspartic Acid; Axons; Calcium; Enzyme-Linked Immunosorbent Assay; Fixatives; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hypothalamus; Immune Sera; Immunoblotting; Immunohistochemistry; N-Methylaspartate; Rats; Synapses | 1991 |
Tyrosine 70 fine-tunes the catalytic efficiency of aspartate aminotransferase.
Topics: Aspartate Aminotransferases; Aspartic Acid; Enzyme Inhibitors; Escherichia coli; Glutamates; Glutamic Acid; Isotopes; Ketoglutaric Acids; Kinetics; Maleates; Mutation; N-Methylaspartate; Spectrophotometry; Tyrosine | 1991 |
Activation of excitatory amino acid receptors cannot alone account for anoxia-induced impairment of protein synthesis in rat hippocampal slices.
Topics: Animals; Aspartic Acid; Carbon Radioisotopes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; Hypoxia; Kainic Acid; Lysine; Male; N-Methylaspartate; Nerve Tissue Proteins; Phenazocine; Phencyclidine; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1991 |
Presynaptic modulation of glutamate and dynorphin release by excitatory amino acids in the guinea-pig hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dynorphins; Glutamates; Guinea Pigs; Hippocampus; Ibotenic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Potassium; Quinoxalines; Quisqualic Acid; Synapses; Synaptosomes | 1991 |
Uneven distribution of excitatory amino acid receptors on ventral horn neurones of newborn rat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Dendrites; Dose-Response Relationship, Drug; Glutamates; Kainic Acid; Membrane Potentials; N-Methylaspartate; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord | 1991 |
Receptor sub-types involved in responses of Purkinje cell to exogenous excitatory amino acids and local electrical stimulation in cerebellar slices in the rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Amino Acids; Animals; Aspartic Acid; Bicuculline; Cerebellum; Electric Stimulation; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Purkinje Cells; Quinoxalines; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1991 |
Excitatory amino acids evoke taurine release from cerebral cortex slices from adult and developing mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dipeptides; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotoxins; Potassium; Quisqualic Acid; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Secretory Rate; Stimulation, Chemical; Taurine | 1991 |
A novel selective NMDA agonist, N-phthalamoyl-L-glutamic acid (PhGA).
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hippocampus; Magnesium; N-Methylaspartate; Neurons; Osmolar Concentration | 1991 |
The pharmacological profile of glutamate-evoked ascorbic acid efflux measured by in vivo electrochemistry.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Ascorbic Acid; Aspartic Acid; Brain; Corpus Striatum; Electric Stimulation; Electrochemistry; Globus Pallidus; Glutamates; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; Microinjections; N-Methylaspartate; Organ Specificity; Potentiometry; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Thalamus | 1991 |
N-methyl-D-aspartate and aspartate raise the cytosolic free calcium concentration by acting upon receptors transiently expressed on immature cerebellar Purkinje cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; Aspartic Acid; Calcium; Cerebellum; Cytosol; Gallopamil; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Magnesium; N-Methylaspartate; Organophosphorus Compounds; Piperazines; Purkinje Cells; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Differences in the regulation of acetylcholine release upon D2 dopamine and N-methyl-D-aspartate receptor activation between the striatal complex of reptiles and the neostriatum of rats.
Topics: Acetylcholine; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Dopamine Agents; Ergolines; Female; In Vitro Techniques; Lizards; Male; N-Methylaspartate; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Species Specificity; Turtles | 1991 |
Sensitivity of rubrospinal neurons to excitatory amino acids in the rat red nucleus in vivo.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Aspartic Acid; Cats; Cerebellum; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Iontophoresis; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Red Nucleus; Species Specificity | 1991 |
Survival of adult basal forebrain cholinergic neurons after loss of target neurons.
Topics: Acetylcholinesterase; Animals; Aspartic Acid; Axonal Transport; Cell Survival; Choline; Diencephalon; Female; Hippocampus; Immunohistochemistry; N-Methylaspartate; Nerve Growth Factors; Neurons, Afferent; Rats; Septal Nuclei; Telencephalon | 1990 |
Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-methyl-D-aspartate antagonists.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Cerebral Cortex; Chemical Phenomena; Chemistry; Drug Design; Imines; In Vitro Techniques; Ion Channels; Models, Molecular; N-Methylaspartate; Polycyclic Compounds; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Thermodynamics | 1990 |
Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead.
Topics: Animals; Aspartic Acid; Calcium; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Conductivity; Glycine; Hippocampus; Ion Channels; Kainic Acid; Lead; Learning Disabilities; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses.
Topics: Animals; Aspartic Acid; Brain; Calcium; Electric Conductivity; Female; Glycine; Kinetics; Membrane Potentials; N-Methylaspartate; Oocytes; Poly A; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA; RNA, Messenger; Xenopus laevis | 1990 |
Inhibition of muscarinic-coupled phosphoinositide hydrolysis by N-methyl-D-aspartate is dependent on depolarization via channel activation.
Topics: Animals; Aspartic Acid; Carbachol; Electrophysiology; Enzyme Activation; Hydrolysis; In Vitro Techniques; Ion Channels; Ion Exchange; Male; Muscarine; N-Methylaspartate; Phosphatidylinositols; Potassium; Protein Kinase C; Rats; Rats, Inbred Strains; Second Messenger Systems; Veratridine | 1990 |
Voltage-gated and chemically gated ionic channels in the cultured cochlear ganglion neurone of the chick.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium Channels; Cell Membrane Permeability; Chick Embryo; Cochlear Nerve; Ganglia; Glutamates; In Vitro Techniques; Ion Channel Gating; Ion Channels; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Potassium Channels; Sodium Channels | 1990 |
Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease.
Topics: Adult; Aspartic Acid; Corpus Striatum; Female; Heterozygote; Humans; Huntington Disease; Immunohistochemistry; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Substance P; Suicide | 1990 |
Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Diazepam; Injections, Intraventricular; Ion Channels; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Piperazines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Serine; Strychnine | 1990 |
Voltage-dependent block by intracellular Mg2+ of N-methyl-D-aspartate-activated channels.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Diencephalon; Egtazic Acid; Embryo, Mammalian; Ion Channels; Kinetics; Magnesium; Mice; N-Methylaspartate; Neurons | 1990 |
Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding Sites; Cerebellum; Electric Conductivity; Glycine; Hydrogen-Ion Concentration; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Protons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
A quantitative description of NMDA receptor-channel kinetic behavior.
Topics: Animals; Aspartic Acid; Ion Channels; Kinetics; Magnesium; Models, Neurological; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Statistics as Topic | 1990 |
A radiohistochemical measure of [3H]TCP binding to the activated NMDA-receptor-gated ion channel in rat brain.
Topics: Animals; Aspartic Acid; Brain; Glycine; Ion Channels; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Polyamines potentiate NMDA induced whole-cell currents in cultured striatal neurons.
Topics: Animals; Aspartic Acid; Cells, Cultured; Corpus Striatum; Female; Fetus; Ion Channels; N-Methylaspartate; Neurons; Polyamines; Pregnancy; Rats | 1990 |
Selective activation of oscillatory currents by trans-ACPD in rat brain mRNA-injected Xenopus oocytes and their blockade by NMDA.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Cycloleucine; Ion Channels; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; RNA, Messenger; Xenopus | 1990 |
Genetic differences in the ethanol sensitivity of GABAA receptors expressed in Xenopus oocytes.
Topics: Animals; Aspartic Acid; Brain; Chloride Channels; Chlorides; Diazepam; Ethanol; Female; gamma-Aminobutyric Acid; Ion Channels; Membrane Proteins; Mice; Mice, Inbred Strains; Microinjections; N-Methylaspartate; Oocytes; Receptors, GABA-A; RNA, Messenger; Xenopus | 1990 |
Spermine and philanthotoxin potentiate excitatory amino acid responses of Xenopus oocytes injected with rat and chick brain RNA.
Topics: Amino Acids; Animals; Aspartic Acid; Bee Venoms; Brain; Chickens; Kainic Acid; Male; Membrane Potentials; Microinjections; N-Methylaspartate; Neurotoxins; Oocytes; Oxadiazoles; Poly A; Polyamines; Quisqualic Acid; Rats; Rats, Inbred Strains; RNA; RNA, Messenger; Spermine; Wasp Venoms; Xenopus | 1990 |
Modulation of the N-methyl-D-aspartate channel by extracellular H+.
Topics: Animals; Aspartic Acid; Cells, Cultured; Embryo, Mammalian; gamma-Aminobutyric Acid; Glycine; Hippocampus; Hydrogen-Ion Concentration; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Miniature excitatory synaptic currents in cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Aspartic Acid; Calcium Channel Blockers; Cells, Cultured; Dipeptides; Electrophysiology; Fetus; Hippocampus; Kinetics; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Oxadiazoles; Potassium; Quisqualic Acid; Synapses; Tetrodotoxin | 1990 |
Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics.
Topics: Animals; Aspartic Acid; Cells, Cultured; Electric Conductivity; Hippocampus; Ion Channel Gating; Ion Channels; Kinetics; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord.
Topics: Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Interactions; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Pain; Pain Measurement; Quisqualic Acid; Rats; Rats, Inbred Strains; Reaction Time; Self Mutilation; Spinal Cord; Substance P; Taurine | 1990 |
Proteolytic enzymes do not destroy the N-methyl-D-aspartate (NMDA) sensitivity of acutely isolated hippocampal CA1 and CA3 neurons from postnatal rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Cell Separation; Dose-Response Relationship, Drug; Drug Synergism; Electric Conductivity; Glycine; Hippocampus; Ion Channels; Magnesium; N-Methylaspartate; Neurons; Peptide Hydrolases; Rats | 1990 |
Currents through single glutamate receptor channels in outside-out patches from rat cerebellar granule cells.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Glutamates; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Time Factors | 1991 |
The actions of a conformationally restricted analogue of aspartic acid on mammalian spinal neurones.
Topics: Action Potentials; Animals; Aspartic Acid; Cycloleucine; Kainic Acid; Molecular Conformation; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Spinal Cord; Stereoisomerism | 1991 |
Role of excitatory amino acid receptors in K+- and glutamate-evoked release of endogenous adenosine from rat cortical slices.
Topics: Adenosine; Animals; Aspartic Acid; Calcium; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Potassium; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1990 |
Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Computer Simulation; Ibotenic Acid; Kainic Acid; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship | 1990 |
[3H]N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine ([3H]TCP) binding in human frontal cortex: decreases in Alzheimer-type dementia.
Topics: Alzheimer Disease; Aspartic Acid; Binding Sites; Frontal Lobe; Glutamates; Glutamic Acid; Humans; Membranes; N-Methylaspartate; Phencyclidine; Reference Values | 1990 |
NMDA receptors mediate poly- and monosynaptic potentials in motoneurons of rat embryos.
Topics: Animals; Aspartic Acid; Electrophysiology; Glutamates; Glutamic Acid; Kainic Acid; Motor Neurons; N-Methylaspartate; Neurons, Afferent; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Nerve Roots; Synapses; Synaptic Transmission | 1990 |
Selective depression of the segmental polysynaptic reflex by phencyclidine and its analogs in the rat in vitro: interaction with N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Binding Sites; Haloperidol; In Vitro Techniques; Magnesium; Male; Methiothepin; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex; Spinal Cord | 1990 |
N-methyl-D-aspartate recognition site ligands modulate activity at the coupled glycine recognition site.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Glutamates; Glutamic Acid; Glycine; Ligands; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines | 1990 |
Effects of hypoxia-ischemia and MK-801 treatment on the binding of a phencyclidine analogue in the developing rat brain.
Topics: Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hypoxia; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Tritium | 1990 |
Failure of sigma-receptor ligands to reduce the excitatory actions of N-methyl-DL-aspartate on rat spinal neurons in-vivo.
Topics: Animals; Aspartic Acid; Haloperidol; In Vitro Techniques; Kainic Acid; Ligands; N-Methylaspartate; Neurons; Oxadiazoles; Piperidines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord; Stereoisomerism | 1990 |
Quisqualate activates N-methyl-D-aspartate receptor channels in hippocampal neurons maintained in culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Electric Stimulation; Glycine; Hippocampus; Indoles; Ion Channel Gating; N-Methylaspartate; Neural Conduction; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Competitive and noncompetitive N-methyl-D-aspartate antagonists modify hypoxia-induced membrane potential changes and protect rat hippocampal slices from functional failure: a quantitative comparison.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Cell Hypoxia; Cell Survival; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1990 |
Posterior midbrain-induced locomotion.
Topics: Animals; Aspartic Acid; Bicuculline; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Locomotion; Mesencephalon; Muscles; N-Methylaspartate; Neurotransmitter Agents; Picrotoxin; Rats; Rats, Inbred Strains | 1990 |
Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Cells, Cultured; Drug Interactions; Female; Glycine; Male; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Spinal Cord | 1990 |
Induction of locomotion in spinal tadpoles by excitatory amino acids and their agonists.
Topics: Animals; Anura; Aspartic Acid; Glutamates; Glutamic Acid; Kainic Acid; Locomotion; Motor Activity; N-Methylaspartate; Spinal Cord; Swimming | 1990 |
N-methyl-D-aspartate receptors contribute to excitatory postsynaptic potentials of cat lateral geniculate neurons recorded in thalamic slices.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Aspartic Acid; Axons; Calcium; Cats; Electric Stimulation; Evoked Potentials; Geniculate Bodies; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Thalamus; Visual Pathways | 1990 |
Evidence for the presence of N-methyl-D-aspartate receptors in the ventral tegmental area of the rat: an electrophysiological in vitro study.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tegmentum Mesencephali | 1990 |
Glutamate and glycine induce a negative wave on hippocampal field response through NMDA receptors.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glycine; Hippocampus; Male; N-Methylaspartate; Neural Inhibition; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Aspartic Acid; Cells, Cultured; Glycine; Hippocampus; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Osmolar Concentration; Piperazines | 1990 |
Acute- and long-term glutamate-mediated regulation of [Ca++]i in rat hippocampal pyramidal neurons in vitro.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Aspartic Acid; Conditioning, Psychological; Fear; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex, Startle | 1990 |
Differential expression of excitatory amino acid receptor subtypes in cultured cerebellar neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Oxadiazoles; Potassium Chloride; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Glutamate uptake in mammalian retinal glia is voltage- and potassium-dependent.
Topics: Animals; Aspartic Acid; Carrier Proteins; Glutamates; Glutamic Acid; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neuroglia; Neurotransmitter Agents; Potassium; Rabbits; Retina | 1990 |
Acetylcholine potentiates responses to N-methyl-D-aspartate in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Action Potentials; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Selective loss of N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain following portacaval anastomosis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ammonia; Animals; Aspartic Acid; Brain; Cerebral Cortex; Corpus Striatum; Down-Regulation; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Liver; Male; N-Methylaspartate; Organ Size; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Thalamus | 1990 |
Glycine-insensitive NMDA-sensitive receptor expressed in Xenopus oocytes by guinea pig cerebellar mRNA.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cerebellum; Electric Conductivity; Female; Glycine; Guinea Pigs; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Phencyclidine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1990 |
Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Kinetics; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Valine | 1990 |
Effects of antagonists on N-methyl-D-aspartate response in acutely isolated nucleus tractus solitarii neurons of the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Medulla Oblongata; N-Methylaspartate; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Cortical neurons containing somatostatin- or parvalbumin-like immunoreactivity are atypically vulnerable to excitotoxic injury in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Fetus; Ibotenic Acid; Kainic Acid; L-Lactate Dehydrogenase; Mice; Muscle Proteins; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Oxazoles; Parvalbumins; Somatostatin | 1990 |
An electrophysiological study of the action of N-methyl-D-aspartate on excitatory synaptic transmission in the optic tectum of the frog in vitro.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electrophysiology; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Rana temporaria; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Superior Colliculi; Synapses; Synaptic Transmission | 1990 |
Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Arachidonic Acid; Arachidonic Acids; Aspartic Acid; Cells, Cultured; Corpus Striatum; Cycloleucine; Electrophysiology; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1990 |
The glycine site modulates NMDA-mediated changes of intracellular free calcium in cultures of hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cells, Cultured; Embryo, Mammalian; Glycine; Hippocampus; Ketamine; Kinetics; Kynurenic Acid; Macromolecular Substances; N-Methylaspartate; Neurons; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1990 |
In vivo evidence for an inhibitory glutamatergic control of serotonin release in the cat caudate nucleus: involvement of GABA neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Bicuculline; Cats; Caudate Nucleus; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurons; Riluzole; Serotonin; Spinal Cord; Synaptic Transmission; Tetrodotoxin; Thiazoles | 1990 |
Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex.
Topics: Allosteric Site; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Hippocampus; Ileum; Isometric Contraction; Kinetics; Male; Muscle, Smooth; N-Methylaspartate; Neurons; Norepinephrine; Pyrrolidinones; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes | 1990 |
Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Ketamine; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Temperature; Time Factors | 1990 |
Spinal antinociceptive effects of excitatory amino acid antagonists: quisqualate modulates the action of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Analgesics; Animals; Aspartic Acid; Dipeptides; Electric Stimulation; Glutamine; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Vocalization, Animal | 1990 |
Veratridine and other depolarizing agents counteract the inhibitory effect of Mg2+ ions on N-methyl-D-aspartate (NMDA)-induced noradrenaline release in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Amifampridine; Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Stimulation; Hydrogen; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Veratridine; Veratrine | 1990 |
N-methyl-D-aspartate stimulates the release of dopamine from rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dopamine; Hippocampus; Interneurons; Male; Memory; N-Methylaspartate; Neuronal Plasticity; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission; Tetrodotoxin | 1990 |
Effect of aspartame on N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain synaptic membranes.
Topics: Animals; Aspartame; Aspartic Acid; Brain; Dipeptides; Glutamates; Glutamic Acid; Kinetics; Male; N-Methylaspartate; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1990 |
Rapid, sensitive, and simple method for quantification of both neurotoxic and neurotrophic effects of NMDA on cultured cerebellar granule cells.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; Culture Media; Dizocilpine Maleate; Glutamates; Glutamic Acid; Mice; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Potassium | 1990 |
Glutamate- and aspartate-induced extracellular potassium and calcium shifts and their relation to those of kainate, quisqualate and N-methyl-D-aspartate in the isolated turtle cerebellum.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cerebellum; Dose-Response Relationship, Drug; Extracellular Space; Glutamates; Glutamic Acid; In Vitro Techniques; Iontophoresis; Kainic Acid; Manganese; N-Methylaspartate; Potassium; Quisqualic Acid; Turtles | 1990 |
Actions of excitatory amino acids on brisk ganglion cells in the cat retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Anesthesia; Animals; Aspartic Acid; Cats; Electrodes; Glutamates; Glutamic Acid; Ibotenic Acid; Iontophoresis; Kainic Acid; N-Methylaspartate; Photic Stimulation; Quisqualic Acid; Retinal Ganglion Cells | 1990 |
Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Serine | 1990 |
Effect of excitatory amino acids on microtubule-associated proteins in cultured cortical and spinal neurones.
Topics: Animals; Aspartic Acid; Axons; Calcium; Cells, Cultured; Cerebral Cortex; Glutamates; Immunohistochemistry; Microtubule-Associated Proteins; N-Methylaspartate; Neurons; Rats; Spinal Cord; tau Proteins | 1990 |
Glutamate receptors of the non-N-methyl-D-aspartic acid type mediate the increase in luteinizing hormone-releasing hormone release by excitatory amino acids in vitro.
Topics: Amino Acids; Animals; Arcuate Nucleus of Hypothalamus; Aspartic Acid; Glutamates; Gonadotropin-Releasing Hormone; Male; Median Eminence; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
The allosteric glycine site of the N-methyl-D-aspartate receptor modulates GABAergic-mediated synaptic events in neonatal rat CA3 hippocampal neurons.
Topics: Aging; Allosteric Regulation; Allosteric Site; Animals; Animals, Newborn; Aspartic Acid; Electric Conductivity; Female; gamma-Aminobutyric Acid; Glycine; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Synapses; Tetrodotoxin | 1990 |
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.
Topics: 4-Butyrolactone; Acoustic Stimulation; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dopamine; Furans; Glycine; In Vitro Techniques; Isomerism; Kinetics; Male; Membrane Potentials; Mice; Mice, Inbred DBA; Motor Activity; N-Methylaspartate; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Seizures; Serotonin | 1990 |
Radioligand labeling of N-methyl-D-aspartic acid (NMDA) receptors by [3H](+-)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid in brain synaptic membranes treated with Triton X-100.
Topics: Affinity Labels; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Brain; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes; Tritium | 1990 |
Changes in excitatory amino acid modulation of phosphoinositide metabolism during development.
Topics: Aging; Animals; Aspartic Acid; Brain; Inositol Phosphates; N-Methylaspartate; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface | 1990 |
Excitatory amino acid receptors on sustained retinal ganglion cells in the kitten during the critical period of development.
Topics: Action Potentials; Aging; Animals; Aspartic Acid; Cats; Kainic Acid; N-Methylaspartate; Oxadiazoles; Photic Stimulation; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Retina; Retinal Ganglion Cells; Visual Pathways | 1990 |
N-methyl-D-aspartate receptors of ganglion cells in rabbit retina.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Electrophysiology; In Vitro Techniques; N-Methylaspartate; Rabbits; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells; Valine | 1990 |
Long-term potentiation and activity-dependent retinotopic sharpening in the regenerating retinotectal projection of goldfish: common sensitive period and sensitivity to NMDA blockers.
Topics: Animals; Aspartic Acid; Behavior, Animal; Goldfish; N-Methylaspartate; Nerve Regeneration; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Retina; Superior Colliculi; Synaptic Transmission; Time Factors | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Phencyclidine; Pyrrolidinones; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Role of N-methyl-D-aspartate (NMDA) receptors in experimental catalepsy in rats.
Topics: Animals; Aspartic Acid; Baclofen; Bromocriptine; Catalepsy; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Interactions; Haloperidol; Male; N-Methylaspartate; Nimodipine; Nitrendipine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Scopolamine | 1990 |
Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices.
Topics: Animals; Aspartic Acid; Calcineurin; Calmodulin-Binding Proteins; Colforsin; Corpus Striatum; Cyclic AMP; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Activation; N-Methylaspartate; Nerve Tissue Proteins; Phosphates; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphothreonine; Protein Kinases; Protein Phosphatase 1; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1990 |
Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: role of the glutamate receptor responsive to N-methyl-D-aspartate.
Topics: Animals; Anticonvulsants; Aspartic Acid; Blood; Cell Survival; Cells, Cultured; Cerebellum; Culture Media; Cytoplasmic Granules; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Piperazines; Potassium Chloride; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Veratridine | 1990 |
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1990 |
GABA and glutamate receptor development of cultured neurons from rat hippocampus, septal region, and neocortex.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Hippocampus; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter; Septal Nuclei | 1990 |
Death of subcortical cholinergic neurons in certain neurodegenerative disorders may not be due to an overstimulation of N-methyl-D-aspartate receptors.
Topics: Animals; Aspartic Acid; Cells, Cultured; Choline O-Acetyltransferase; Cholinergic Fibers; Frontal Lobe; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Septal Nuclei | 1990 |
Memory and amnesia.
Topics: Amnesia; Aspartic Acid; Frontal Lobe; Humans; Memory; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Structure and activity of hydrogenated derivatives of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801).
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Molecular Conformation; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1990 |
A unified approach to systematic isosteric substitution for acidic groups and application to NMDA antagonists related to 2-amino-7-phosphonoheptanoate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Models, Molecular; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1990 |
Glutamate receptor agonists cause efflux of endogenous neuroactive amino acids from cerebellar neurons in culture.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
(+)-[3H]MK-801 binding sites in postmortem human brain.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Female; Humans; Male; Middle Aged; N-Methylaspartate; Postmortem Changes; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereoisomerism; Tissue Distribution; Tritium | 1990 |
Structural determinants of affinity for the phencyclidine binding site of the N-methyl-D-aspartate receptor complex: discovery of a rigid phencyclidine analogue of high binding affinity.
Topics: Animals; Aspartic Acid; Computer Graphics; Crystallography; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Models, Molecular; Molecular Conformation; Molecular Structure; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; X-Ray Diffraction | 1990 |
The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Calcium Channels; Drug Antagonism; Ibotenic Acid; In Vitro Techniques; Ion Channel Gating; Kainic Acid; Mice; N-Methylaspartate; Neurons; Nifedipine; Quinolinic Acid; Quinolinic Acids; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Sigma receptors modulate the hypothalamic-pituitary-adrenal (HPA) axis centrally: evidence for a functional interaction with NMDA receptors, in vivo.
Topics: Adrenocorticotropic Hormone; Animals; Aspartic Acid; Cells, Cultured; Hypothalamo-Hypophyseal System; Male; N-Methylaspartate; Pentazocine; Phenazocine; Piperazines; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, sigma | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
NMDA receptor agonist and antagonists alter retinal ganglion cell arbor structure in the developing frog retinotectal projection.
Topics: Animals; Aspartic Acid; Dendrites; Dibenzocycloheptenes; Dizocilpine Maleate; Larva; N-Methylaspartate; Rana pipiens; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells; Superior Colliculi; Synaptic Transmission | 1990 |
Evidence against an involvement of the haloperidol-sensitive sigma recognition site in the discriminative stimulus properties of (+)-N-allylnormetazocine ((+)-SKF 10,047).
Topics: Animals; Aspartic Acid; Binding, Competitive; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Guanidines; Haloperidol; Male; Mice; N-Methylaspartate; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures | 1990 |
N-methyl-D-aspartate/phencyclidine receptor complex of rat forebrain: purification and biochemical characterization.
Topics: Animals; Aspartic Acid; Brain; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Glutamates; Glycine; Male; Molecular Weight; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Solubility | 1990 |
Effect of NMDA and 2-amino-7-phosphonoheptanoate focal injection into the ventrolateral thalamic nucleus on the high pressure neurological syndrome in the rat.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Central Nervous System Diseases; High Pressure Neurological Syndrome; Male; Microinjections; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Thalamic Nuclei | 1990 |
Stimulatory and inhibitory actions of excitatory amino acids on inositol phospholipid metabolism in rabbit retina. Evidence for a specific quisqualate receptor subtype associated with neurones.
Topics: Animals; Aspartic Acid; Calcium; Carbachol; Dose-Response Relationship, Drug; Ibotenic Acid; In Vitro Techniques; Inositol Phosphates; Kainic Acid; N-Methylaspartate; Norepinephrine; Oxadiazoles; Quisqualic Acid; Rabbits; Receptors, AMPA; Receptors, Neurotransmitter; Retina | 1990 |
Cyclazocine and pentazocine as N-methylaspartate antagonists on cat and rat spinal neurons in vivo.
Topics: Animals; Aspartic Acid; Cats; Cyclazocine; Injections, Intravenous; N-Methylaspartate; Neurons; Pentazocine; Rats; Rats, Inbred Strains; Spinal Nerves; Stereoisomerism; Synapses; Synaptic Transmission | 1990 |
PD117302, a selective non-peptide opioid kappa agonist, protects against NMDA and maximal electroshock convulsions in rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dose-Response Relationship, Drug; Electroshock; Flurothyl; Male; N-Methylaspartate; Pyrroles; Random Allocation; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes; Time Factors | 1990 |
Glycine-insensitive desensitization of NMDA responses in cultured mouse embryonic neurons.
Topics: Animals; Aspartic Acid; Cells, Cultured; Electric Conductivity; Electrophysiology; Glycine; Mice; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Interfering with glutamatergic neurotransmission by means of NMDA antagonist administration discloses the locomotor stimulatory potential of other transmitter systems.
Topics: Animals; Aspartic Acid; Atropine; Biogenic Monoamines; Clonidine; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Glutamates; Ketamine; Male; Mice; Motor Activity; N-Methylaspartate; Rats; Rats, Inbred Strains; Synaptic Transmission | 1990 |
Stereospecific blockade of N-methyl-D-aspartate transmission by MK 801 prevents priming of SKF 38393-induced turning.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hydroxydopamines; Male; N-Methylaspartate; Oxidopamine; Rats; Rats, Inbred Strains; Stereoisomerism; Stereotyped Behavior; Sympathectomy, Chemical; Synaptic Transmission | 1990 |
6,7-Dinitroquinoxaline-2,3-dione blocks the cytotoxicity of N-methyl-D-aspartate and kainate, but not quisqualate, in cortical cultures.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Hippocampus; Kainic Acid; Ligands; N-Methylaspartate; Neurotoxins; Norepinephrine; Oxadiazoles; Quinoxalines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
N-methyl-D-aspartate-evoked calcium uptake by kitten visual cortex maintained in vitro.
Topics: Animals; Aspartic Acid; Calcium; Cats; Darkness; Functional Laterality; In Vitro Techniques; N-Methylaspartate; Potassium; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sensory Deprivation; Visual Cortex | 1990 |
Ethanol inhibits N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat cortical slices.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Culture Techniques; Ethanol; Glycine; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin; Valine | 1990 |
Chemically induced hypoglycemia and anoxia: relationship to glutamate receptor-mediated toxicity in retina.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Aspartic Acid; Chick Embryo; Electron Transport; Glycolysis; Hypoglycemia; Hypoxia; Iodoacetates; Iodoacetic Acid; N-Methylaspartate; Phosphocreatine; Receptors, Glutamate; Receptors, Neurotransmitter; Retina | 1990 |
Differential modulation of the associated glycine recognition site by competitive N-methyl-D-aspartate receptor antagonists.
Topics: Amino Acids; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Glycine; Male; N-Methylaspartate; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1990 |
Subtypes of excitatory amino acid receptors involved in the stimulation of [3H]dopamine release from cell cultures of rat ventral mesencephalon.
Topics: Animals; Aspartic Acid; Cells, Cultured; Dopamine; Kynurenic Acid; Magnesium; Mesencephalon; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1990 |
N-methyl-D-aspartate-induced neuronal activation is selectively modulated by sigma receptors.
Topics: Animals; Aspartic Acid; Guanidines; Haloperidol; In Vitro Techniques; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Spiperone | 1990 |
In vivo interaction of a polyamine with the NMDA receptor.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Spermidine | 1990 |
N-methyl-D-aspartate receptor activation and Ca2+ account for poor pyramidal cell structure in hippocampal slices.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Aspartic Acid; Buffers; Cell Nucleus; Cytoplasm; Cytoskeleton; Endoplasmic Reticulum; Guinea Pigs; Hippocampus; Ketamine; Magnesium; Microscopy, Electron; Mitochondria; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Excitatory amino acids and cardiovascular apparatus: experimental studies on conscious rats with L-glutamate, N-methyl-D-aspartate, kainate and quisqualate.
Topics: Amino Acids; Animals; Aspartic Acid; Cardiovascular Physiological Phenomena; Cardiovascular System; Glutamates; Injections, Intraventricular; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Synaptic Transmission | 1990 |
Maturation of the hypothalamic control of pulsatile gonadotropin-releasing hormone secretion at onset of puberty. I. Increased activation of N-methyl-D-aspartate receptors.
Topics: Aging; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Gonadotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Hypothalamus; Kinetics; Magnesium; Male; N-Methylaspartate; Organ Culture Techniques; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sexual Maturation; Spermatids; Testis | 1990 |
Glutamate-receptor-mediated regulation of the cytoplasmic free calcium level in cultured cerebellar granule cells.
Topics: Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Cytoplasm; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamates; Glycine; Kainic Acid; Magnesium; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Mode of blockade by MK-801 of N-methyl-D-aspartate-induced increase in intracellular Ca2+ in cultured mouse hippocampal neurons.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; Mice; Mice, Inbred ICR; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Temperature | 1990 |
Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Glycine; Hippocampus; Kainic Acid; Kinetics; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1990 |
Restoration of the plasticity of binocular maps by NMDA after the critical period in Xenopus.
Topics: Animals; Aspartic Acid; Axons; Functional Laterality; Glutamates; Models, Neurological; N-Methylaspartate; Neuronal Plasticity; Neurons; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Superior Colliculi; Vision, Binocular; Visual Fields; Xenopus laevis | 1990 |
21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Glucose; Lipid Peroxidation; Lipid Peroxides; Membrane Potentials; Mice; N-Methylaspartate; Nerve Degeneration; Neurons; Pregnatrienes; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Brain; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Stereoisomerism | 1990 |
In vivo antagonism of agonist actions at N-methyl-D-aspartate and N-methyl-D-aspartate-associated glycine receptors in mouse cerebellum: studies of 1-hydroxy-3-aminopyrrolidone-2.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Male; Mice; N-Methylaspartate; Pyrrolidinones; Receptors, Glycine; Receptors, Neurotransmitter | 1990 |
NMDA-independent form of long-term potentiation produced by tetraethylammonium in the hippocampal CA1 region.
Topics: 4-Aminopyridine; Animals; Aspartic Acid; Calcium Channels; Drug Synergism; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Tetraethylammonium Compounds | 1990 |
Pre- and postsynaptic excitatory action of glutamate agonists on frog vestibular receptors.
Topics: Afferent Pathways; Animals; Aspartic Acid; Glutamates; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana esculenta; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission; Vestibule, Labyrinth | 1990 |
Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2.
Topics: Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Microtubule-Associated Proteins; N-Methylaspartate; Peptide Mapping; Phosphorylation; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Time Factors; Tissue Distribution | 1990 |
Involvement of NMDA receptors in non-convulsive epilepsy in WAG/Rij rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Electroencephalography; Epilepsy; Female; Injections, Intraventricular; Male; N-Methylaspartate; Rats; Rats, Mutant Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Excitatory amino acid response in isolated nucleus tractus solitarii neurons of the rat.
Topics: Amino Acids; Animals; Aspartic Acid; Electrophysiology; Glycine; In Vitro Techniques; Kainic Acid; Medulla Oblongata; N-Methylaspartate; Neurons; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1990 |
N-methyl-D-aspartate-sensitive glutamate receptors induce calcium-mediated arachidonic acid release in primary cultures of cerebellar granule cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Cholera Toxin; Glutamates; Granulocytes; Ionomycin; N-Methylaspartate; Phospholipases A; Phospholipases A2; Quinacrine; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Type C Phospholipases; Virulence Factors, Bordetella | 1990 |
Comparison of the neuroprotective effects of the N-methyl-D-aspartate antagonist MK-801 and the opiate-receptor antagonist nalmefene in experimental spinal cord ischemia.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Humans; Ischemia; Male; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Rabbits; Spinal Cord; Time Factors | 1990 |
Effect of N-methyl-d,l-aspartate on luteinizing hormone secretion in ovariectomized ewes in the absence and presence of estradiol.
Topics: Animals; Aspartic Acid; Estradiol; Female; Injections, Intravenous; Injections, Subcutaneous; Luteinizing Hormone; N-Methylaspartate; Ovariectomy; Pituitary Gland, Anterior; Sheep | 1990 |
Binding of [3H]ifenprodil, a novel NMDA antagonist, to a polyamine-sensitive site in the rat cerebral cortex.
Topics: Animals; Aspartic Acid; Biogenic Polyamines; Cerebral Cortex; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Piperidines; Rats; Rats, Inbred Strains | 1990 |
Magnesium reduces N-methyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats.
Topics: Animals; Aspartic Acid; Brain; Corpus Striatum; Dose-Response Relationship, Drug; Magnesium; Microinjections; N-Methylaspartate; Neurotoxins; Organ Size; Rats; Rats, Inbred Strains; Seizures | 1990 |
Conantokin-T. A gamma-carboxyglutamate containing peptide with N-methyl-d-aspartate antagonist activity.
Topics: 1-Carboxyglutamic Acid; Amino Acid Sequence; Animals; Aspartic Acid; Benzofurans; Calcium; Cerebellum; Chromatography, Gel; Conotoxins; Fluorescent Dyes; Fura-2; Intercellular Signaling Peptides and Proteins; Mass Spectrometry; Mice; Molecular Sequence Data; Mollusk Venoms; N-Methylaspartate; Neurons; Peptides; Rats; Seizures; Sequence Homology, Nucleic Acid; Snails | 1990 |
Augmentation of N-methyl-D-aspartate induced depolarizations by GABA in neocortical and archicortical neurons.
Topics: Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Hippocampus; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Rats | 1990 |
Resolution of the neuroexcitatory N-methylaspartic acid (2-methylaminosuccinic acid) enantiomers by ligand-exchange thin-layer chromatography.
Topics: Aspartic Acid; Chromatography, Thin Layer; Ligands; N-Methylaspartate | 1990 |
Metabolic interfaces between growth and reproduction. III. Central mechanisms controlling pulsatile luteinizing hormone secretion in the nutritionally growth-limited female lamb.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Female; Food Deprivation; Gonadotropin-Releasing Hormone; Growth Disorders; Hypothalamus, Middle; Luteinizing Hormone; Median Eminence; N-Methylaspartate; Naloxone; Preoptic Area; Sheep | 1990 |
Antagonism between intracerebroventricularly administered N-methyl-D-aspartate and bicuculline methiodide in induction of clonic seizures in mice.
Topics: Animals; Aspartic Acid; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Seizures | 1990 |
Glucose deprivation neuronal injury in vitro is modified by withdrawal of extracellular glutamine.
Topics: Animals; Aspartic Acid; Extracellular Space; Glucose; Glutamine; N-Methylaspartate; Neurons | 1990 |
L-cysteine, a bicarbonate-sensitive endogenous excitotoxin.
Topics: Animals; Animals, Newborn; Anticonvulsants; Aspartic Acid; Bicarbonates; Caudate Nucleus; Chick Embryo; Cysteine; Dibenzocycloheptenes; Dizocilpine Maleate; N-Methylaspartate; Necrosis; Neurons; Neurotoxins; Rats; Rats, Inbred Strains; Retina; Retinal Ganglion Cells; Zinc | 1990 |
Two types of motor rhythm induced by NMDA and amines in an in vitro spinal cord preparation of neonatal rat.
Topics: Action Potentials; Animals; Animals, Newborn; Aspartic Acid; In Vitro Techniques; Motor Neurons; Muscles; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord | 1990 |
Ethanol inhibits NMDA-activated current but does not alter GABA-activated current in an isolated adult mammalian neuron.
Topics: Animals; Aspartic Acid; Ethanol; gamma-Aminobutyric Acid; Ganglia, Spinal; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons, Afferent; Rats; Rats, Inbred Strains | 1990 |
Medioventral medulla-induced locomotion.
Topics: Animals; Aspartic Acid; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Locomotion; Medulla Oblongata; N-Methylaspartate; Parasympathomimetics; Rats; Rats, Inbred Strains | 1990 |
Effects of the NMDA antagonists CPP and MK-801 on radial arm maze performance in rats.
Topics: Animals; Aspartic Acid; Behavior, Animal; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Memory; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Single-Blind Method | 1990 |
The noncompetitive N-methyl-D-aspartate antagonists, MK-801, phencyclidine and ketamine, increase the potency of general anesthetics.
Topics: Anesthesia, General; Anesthetics; Animals; Aspartic Acid; Behavior, Animal; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Ketamine; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Phencyclidine | 1990 |
Neuritogenesis in cerebellar granule cells in vitro: a role for protein kinase C.
Topics: Alkaloids; Animals; Aspartic Acid; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellum; Dendrites; Enzyme Inhibitors; N-Methylaspartate; Protein Kinase C; Rats; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Interaction of strychnine-insensitive glycine binding with MK-801 binding in brain synaptic membranes.
Topics: Animals; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Interactions; Glycine; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Spinal Cord; Stereoisomerism; Strychnine; Synaptic Membranes | 1990 |
N-methyl D-aspartate (NMDA) evoked changes in blood pressure and heart rate from the rat superior colliculus.
Topics: Animals; Aspartic Acid; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Heart Rate; Male; Mesencephalon; N-Methylaspartate; Rats; Superior Colliculi | 1990 |
N-methyl-D-aspartate antagonism and phencyclidine-like activity: a drug discrimination analysis.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Injections, Intraperitoneal; Kainic Acid; Male; Mice; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains | 1990 |
Medial septal neurons containing N-acetyl-aspartyl-glutamate-like immunoreactivity project to the hippocampal formation in the rat.
Topics: Animals; Aspartic Acid; Hippocampus; Immunohistochemistry; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Septal Nuclei | 1990 |
Role of endogenous taurine on the glutamate analogue-induced neurotoxicity in the rat hippocampus in vivo.
Topics: Animals; Aspartic Acid; Extracellular Space; Hippocampus; Kainic Acid; N-Methylaspartate; Osmolar Concentration; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Sucrose; Taurine | 1990 |
Microionophoretic study with milacemide, a glycine precursor, on mammalian central nervous system cells.
Topics: Acetamides; Animals; Aspartic Acid; Brain; Cats; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glycine; Iontophoresis; Kainic Acid; Monoamine Oxidase Inhibitors; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid | 1990 |
Unexpected inhibitory action of N-methyl-D,L-aspartate or luteinizing hormone release in adult ovariectomized rhesus monkeys: a role of the hypothalamic-adrenal axis.
Topics: Animals; Aspartic Acid; Circadian Rhythm; Corticotropin-Releasing Hormone; Female; Gonadotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Immune Sera; Luteinizing Hormone; Macaca mulatta; N-Methylaspartate; Naloxone; Ovariectomy; Pituitary-Adrenal System; Reference Values | 1990 |
Role of the paraventricular nucleus in controlling the frequency of milk ejection and the facilitatory effect of centrally administered oxytocin in the suckled rat.
Topics: Animals; Aspartic Acid; Female; Injections, Intraventricular; Lactation; Milk Ejection; N-Methylaspartate; Oxytocin; Paraventricular Hypothalamic Nucleus; Pregnancy; Rats; Rats, Inbred Strains | 1990 |
Stereospecificity of N-MDA-induced functional deficits.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Behavior, Animal; Hippocampus; Learning; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Inbred F344; Stereoisomerism | 1990 |
Locomotor recovery in spinal-transected lamprey: regenerated spinal coordinating neurons and mechanosensory inputs couple locomotor activity across a spinal lesion.
Topics: Animals; Aspartic Acid; Brain; Brain Stem; Electric Stimulation; Electrophysiology; Fishes; Lampreys; Mechanoreceptors; Motor Activity; Movement; Muscles; N-Methylaspartate; Nerve Regeneration; Reference Values; Spinal Cord | 1990 |
Excitotoxic lesions of the paraventricular hypothalamus: metabolic and cardiac effects.
Topics: Animals; Aspartic Acid; Blood Pressure; Body Weight; Brain; Cardiovascular System; Heart Rate; Homeostasis; Male; Myocardium; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Pressoreceptors; Rats; Rats, Inbred Strains | 1990 |
NMDA and quisqualate reduce a Ca-dependent K+ current by a protein kinase-mediated mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aspartic Acid; Calcium; Enzyme Inhibitors; Hippocampus; Isoquinolines; Male; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Piperazines; Potassium; Protein Kinases; Quisqualic Acid; Rats; Rats, Inbred F344; Second Messenger Systems | 1990 |
Age-related changes in uptake and release on L-[3H]noradrenaline in brain slices of senescence accelerated mouse.
Topics: Aging; Animals; Aspartic Acid; Biological Transport; Brain; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Norepinephrine; Potassium Chloride | 1990 |
The NMDA antagonist, MK-801, suppresses long-term potentiation, kindling, and kindling-induced potentiation in the perforant path of the unanesthetized rat.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Stimulation; Evoked Potentials; Kindling, Neurologic; Male; N-Methylaspartate; Rats; Reference Values; Synapses | 1990 |
Effects of N-methyl-D-aspartate on [Ca2+]i and the energy state in the brain by 19F- and 31P-nuclear magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Calcium; Cerebral Cortex; Energy Metabolism; Fluorine; Guinea Pigs; In Vitro Techniques; Magnesium; Magnetic Resonance Spectroscopy; N-Methylaspartate; Neurotoxins; Phosphorus | 1990 |
GABA does not protect cerebro-cortical cultures against excitotoxic cell death.
Topics: Animals; Aspartic Acid; Cell Survival; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamates; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurotoxins; Oxadiazoles; Pregnancy; Quisqualic Acid; Rats; Rats, Inbred Strains | 1990 |
Neuropeptide Y selectively potentiates N-methyl-D-aspartate-induced neuronal activation.
Topics: Animals; Aspartic Acid; Drug Synergism; Haloperidol; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Neuropeptide Y; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1990 |
Influence of MK-801 on brain extracellular calcium and potassium activities in severe hypoglycemia.
Topics: Animals; Aspartic Acid; Blood Glucose; Blood Pressure; Brain; Calcium; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Electrophysiology; Extracellular Space; Hypoglycemia; Male; N-Methylaspartate; Potassium; Rats; Rats, Inbred Strains | 1990 |
Ethanol inhibition of N-methyl-D-aspartate-stimulated endogenous dopamine release from rat striatal slices: reversal by glycine.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Dopamine Antagonists; Ethanol; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains | 1990 |
Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia.
Topics: Animals; Aspartic Acid; Body Temperature; Dibenzocycloheptenes; Dizocilpine Maleate; Female; Gerbillinae; Hypothermia, Induced; Ischemic Attack, Transient; N-Methylaspartate; Neurons | 1990 |
Comparison of anticonvulsant effect of ethanol against NMDA-, kainic acid- and picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Ethanol; Kainic Acid; Male; N-Methylaspartate; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1990 |
Intraventricular injection of an N-methyl-D-aspartate antagonist disrupts vestibular compensation.
Topics: Animals; Aspartic Acid; Eye Movements; Guinea Pigs; Injections, Intraventricular; N-Methylaspartate; Piperazines; Posture; Vestibule, Labyrinth | 1990 |
Localization of neutral endopeptidase-24.11 (enkephalinase) to N-methyl-D-aspartate sensitive cell populations in the rat forebrain.
Topics: Animals; Aspartic Acid; Brain; Globus Pallidus; Histocytochemistry; Male; N-Methylaspartate; Neprilysin; Putamen; Rats; Rats, Inbred Strains | 1990 |
Effects of N-methyl-D-aspartate antagonism on spatial learning in mice.
Topics: Animals; Aspartic Acid; Female; Learning; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Piperazines; Space Perception | 1990 |
Theophylline down-regulates adenosine receptor function.
Topics: Adenosine; Animals; Aspartic Acid; Isoproterenol; Male; Mice; N-Methylaspartate; Receptors, Purinergic; Serotonin; Theophylline | 1990 |
Kainic acid responses and toxicity show pronounced Ca2+ dependence.
Topics: Animals; Aspartic Acid; Calcium; Drug Interactions; In Vitro Techniques; Ion Channels; Iontophoresis; Kainic Acid; Limbic System; Magnesium; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats | 1985 |
Evidence that excitatory amino acids not only activate the receptor channel complex but also lead to use-dependent block.
Topics: Amino Acids; Animals; Aspartic Acid; Chick Embryo; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Neurotransmitter; Spinal Cord | 1986 |
The induction and modification of voltage-sensitive responses in cat neocortical neurons by N-methyl-D-aspartate.
Topics: Animals; Aspartic Acid; Calcium; Cats; Cerebral Cortex; Drug Interactions; Female; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1986 |
N-methylaspartate-activated calcium channels in rat brain cortex slices. Effect of calcium channel blockers and of inhibitory and depressant substances.
Topics: Animals; Aspartic Acid; Cadmium; Calcium Channel Blockers; Central Nervous System Depressants; Cerebral Cortex; Cobalt; gamma-Aminobutyric Acid; Ion Channels; Morphine; N-Methylaspartate; Nifedipine; Rats; Tetrodotoxin; Time Factors | 1986 |
Phencyclidine selectively blocks a spinal action of N-methyl-D-aspartate in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Norepinephrine; Oxadiazoles; Phencyclidine; Quisqualic Acid; Spinal Cord; Substance P; Tetrazoles; Valine | 1986 |
Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamates; In Vitro Techniques; Ion Channels; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Valine | 1986 |
Inward currents in cat neocortical neurons studied in vitro.
Topics: Animals; Aspartic Acid; Calcium; Cats; Cerebral Cortex; Electric Conductivity; Epilepsies, Partial; In Vitro Techniques; Ion Channels; N-Methylaspartate; Sodium; Tetrodotoxin | 1986 |
Evidence for a magnesium-insensitive membrane resistance increase during NMDA-induced depolarizations in rat neocortical neurons in vitro.
Topics: Animals; Aspartic Acid; Cell Membrane; Electric Conductivity; Frontal Lobe; Glutamates; Glutamic Acid; Ion Channels; Magnesium; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1987 |
A study of amino acid-activated currents recorded from frog motoneurones in vitro.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anterior Horn Cells; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Ion Channels; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neural Conduction; Oxadiazoles; Quisqualic Acid; Rana temporaria; Valine | 1987 |
Phencyclidine and related drugs bind to the activated N-methyl-D-aspartate receptor-channel complex in rat brain membranes.
Topics: Amino Acids; Anesthetics, Dissociative; Animals; Aspartic Acid; Brain; Ion Channels; Male; N-Methylaspartate; Narcotics; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Subcellular Fractions | 1987 |
Use-dependent block of excitatory amino acid currents in cultured neurons by ketamine.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Electric Conductivity; Glutamates; Glutamic Acid; Hippocampus; Ion Channels; Kainic Acid; Ketamine; Membrane Potentials; Mice; N-Methylaspartate; Spinal Cord | 1987 |
Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III.
Topics: Amino Acids; Animals; Arsenazo III; Aspartic Acid; Azo Compounds; Calcium; Cells, Cultured; Ion Channels; Mice; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1987 |
Is activation of N-methyl-D-aspartate receptor gated channels sufficient to induce long term potentiation?
Topics: Action Potentials; Animals; Aspartic Acid; Electric Stimulation; Hippocampus; In Vitro Techniques; Ion Channels; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.
Topics: Action Potentials; Animals; Anticonvulsants; Aspartic Acid; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Ion Channels; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Visual Cortex | 1988 |
The effect of intracellular tetraethylammonium ions on the reversal potential of monosynaptic EPSPs and excitatory amino acids in cultured spinal cord neurones.
Topics: Animals; Aspartic Acid; Cells, Cultured; Dendrites; Ion Channels; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Reflex, Monosynaptic; Spinal Cord; Synapses; Tetraethylammonium Compounds | 1988 |
Receptor-linked ionic channels mediate N-methyl-D-aspartate neurotoxicity in rat cerebellar slices.
Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Ion Channels; Magnesium; N-Methylaspartate; Neurons; Potassium; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Phencyclidine and glycine modulate NMDA-activated high conductance cationic channels by acting at different sites.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebellum; Cerebral Cortex; Electric Conductivity; Glycine; Ion Channels; N-Methylaspartate; Neurons; Phencyclidine; Rats | 1988 |
Sustained dendritic gradients of Ca2+ induced by excitatory amino acids in CA1 hippocampal neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Benzofurans; Calcium; Dendrites; Fluorescent Dyes; Fura-2; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Ion Channels; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Potassium; Protein Kinase C; Sphingosine; Tetrodotoxin | 1988 |
Noncompetitive N-methyl-D-aspartate antagonists affect multiple ionic currents.
Topics: Action Potentials; Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; Ion Channels; Ketamine; N-Methylaspartate; Phencyclidine; Potassium; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1988 |
On the kinetics of large-conductance glutamate-receptor ion channels in rat cerebellar granule neurons.
Topics: Animals; Aspartic Acid; Cerebellum; Glutamates; Glutamic Acid; Ion Channels; Membrane Potentials; N-Methylaspartate; Neural Conduction; Neurons; Organ Culture Techniques; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1988 |
Phencyclidine and some of its analogues have distinct effects on NMDA receptors of rat hippocampal neurons.
Topics: Animals; Aspartic Acid; Electric Conductivity; Hippocampus; Ion Channels; Kinetics; N-Methylaspartate; Neurons; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Behavior induced by putative nociceptive neurotransmitters is inhibited by adenosine or adenosine analogs coadministered intrathecally.
Topics: Adenosine; Animals; Aspartic Acid; Behavior, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Spinal; Male; Mice; N-Methylaspartate; Neurotransmitter Agents; Pain; Substance P | 1988 |
N-methyl-D-aspartate-activated channels of mouse central neurones in magnesium-free solutions.
Topics: Animals; Aspartic Acid; Cells, Cultured; Electric Conductivity; Ion Channels; Magnesium; Mice; N-Methylaspartate; Neurons; Sodium Glutamate | 1988 |
Noise and single channels activated by excitatory amino acids in rat cerebellar granule neurones.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1988 |
Differences in the pore sizes of the N-methyl-D-aspartate and kainate cation channels.
Topics: Animals; Aspartic Acid; Brain; Calcium; Cations; Cell Membrane Permeability; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Strontium | 1988 |
Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anticonvulsants; Aspartic Acid; Atmospheric Pressure; Calcium Channel Blockers; Electrophysiology; Male; N-Methylaspartate; Nimodipine; Nitrendipine; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1988 |
Structural requirements for activation of the glycine receptor that modulates the N-methyl-D-aspartate operated ion channel.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Glycine; Ion Channels; N-Methylaspartate; Phencyclidine; Rats; Receptors, Glycine; Receptors, Neurotransmitter | 1988 |
N-methyl-D-aspartate activates different channels than do kainate and quisqualate.
Topics: Animals; Aspartic Acid; Brain Chemistry; Electric Conductivity; Female; Ion Channels; Kainic Acid; Magnesium; Male; N-Methylaspartate; Oocytes; Oxadiazoles; Phencyclidine; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1989 |
Indole-2-carboxylic acid: a competitive antagonist of potentiation by glycine at the NMDA receptor.
Topics: Animals; Aspartic Acid; Carboxylic Acids; Cells, Cultured; Electric Conductivity; Glycine; In Vitro Techniques; Indoles; Ion Channels; N-Methylaspartate; Neural Inhibition; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1989 |
Ethanol inhibits NMDA-activated ion current in hippocampal neurons.
Topics: 1-Butanol; Aspartic Acid; Butanols; Calcium Channels; Chloride Channels; Chlorides; Electric Conductivity; Ethanol; gamma-Aminobutyric Acid; Hippocampus; Humans; Ion Channels; Kainic Acid; Membrane Proteins; Methanol; N-Methylaspartate; Neurons; Oxadiazoles; Pentanols; Quisqualic Acid; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium Channels | 1989 |
Muscimol, gamma-aminobutyric acidA receptors and excitatory amino acids in the mouse spinal cord.
Topics: Analgesia; Animals; Aspartic Acid; Baclofen; Behavior, Animal; Bicuculline; Kainic Acid; Male; Mice; Muscimol; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, GABA-A; Spinal Cord; Substance P | 1989 |
In vivo characterization of phencyclidine/sigma agonist-mediated inhibition of nociception.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Binding, Competitive; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Mice; N-Methylaspartate; Nociceptors; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, Opioid, delta; Substance P | 1989 |
Ethanol potentiates and blocks NMDA-activated single-channel currents in rat hippocampal pyramidal cells.
Topics: Animals; Aspartic Acid; Cells, Cultured; Drug Synergism; Electric Conductivity; Ethanol; Female; Hippocampus; Ion Channels; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains | 1989 |
Differential dependence on Ca2+ of N-methyl-D-aspartate and quisqualate neurotoxicity in young rat hippocampal slices.
Topics: Animals; Aspartic Acid; Calcium; Cell Survival; Chlorides; Hippocampus; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Staining and Labeling | 1989 |
Unique properties of non-N-methyl-D-aspartate excitatory responses in cultured purkinje neurons.
Topics: Action Potentials; Animals; Aspartic Acid; Cadmium; Calcium; Cations, Divalent; Choline; Electric Conductivity; Ion Channels; Kainic Acid; Kynurenic Acid; Magnesium; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Sucrose; Tetrodotoxin | 1989 |
Stimulation of the N-methyl-D-aspartate receptor promotes the biochemical differentiation of cerebellar granule neurons and not astrocytes.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Astrocytes; Cell Differentiation; Cells, Cultured; Cerebellum; Glutaminase; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA; Valine | 1989 |
Multiple conductance channels in type-2 cerebellar astrocytes activated by excitatory amino acids.
Topics: Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebellum; Convulsants; Electric Conductivity; Evoked Potentials; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Synaptic Transmission | 1989 |
In vivo labelling of the NMDA receptor channel complex by [3H]MK-801.
Topics: Affinity Labels; Animals; Anticonvulsants; Aspartic Acid; Binding Sites; Binding, Competitive; Dibenzocycloheptenes; Dioxolanes; Dizocilpine Maleate; Ion Channels; Male; Mice; N-Methylaspartate; Phenazocine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1988 |
Glycine regulation of the N-methyl-D-aspartate receptor-gated ion channel in hippocampal membranes.
Topics: Allosteric Regulation; Animals; Aspartic Acid; Cell Membrane; Glutamates; Glycine; Hippocampus; In Vitro Techniques; Ion Channels; Kinetics; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Synergism; Electric Conductivity; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neuropeptides; Oxadiazoles; Peptides; Quisqualic Acid; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1989 |
Release of endogenous excitatory amino acids from turtle photoreceptors.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Electric Stimulation; Glutamates; Glutamic Acid; Hippocampus; Ion Channels; Lanthanum; Membrane Potentials; N-Methylaspartate; Neurons; Photoreceptor Cells; Receptors, Nicotinic; Turtles | 1989 |
Cloning by functional expression of a member of the glutamate receptor family.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Brain Chemistry; Cloning, Molecular; DNA; Electrophysiology; Gene Expression; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Molecular Sequence Data; Molecular Weight; N-Methylaspartate; Oocytes; Plasmids; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA; Tissue Distribution; Transcription, Genetic; Transfection; Xenopus | 1989 |
Morphine (intracerebroventricular) activates spinal systems to inhibit behavior induced by putative pain neurotransmitters.
Topics: Animals; Aspartic Acid; Behavior, Animal; Dose-Response Relationship, Drug; Male; Methysergide; Mice; Morphine; N-Methylaspartate; Naloxone; Neurotransmitter Agents; Nociceptors; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Receptors, Serotonin; Spinal Cord; Substance P | 1989 |
Open channel block of NMDA receptor responses evoked by tricyclic antidepressants.
Topics: Animals; Antidepressive Agents, Tricyclic; Aspartic Acid; Cells, Cultured; Convulsants; Desipramine; Embryo, Mammalian; Hippocampus; Ion Channels; Kinetics; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Substitution of a lysyl residue for arginine 386 of Escherichia coli aspartate aminotransferase.
Topics: Amino Acid Sequence; Arginine; Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Catalysis; Escherichia coli; Kinetics; Lysine; Mutation; N-Methylaspartate; Substrate Specificity | 1989 |
Effects of the NMDA antagonists CPP and MK-801 on delayed conditional discrimination.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1989 |
Role of the ventral surface of medulla in the generation of Mayer waves.
Topics: Animals; Aspartic Acid; Blood Pressure; Carbon Dioxide; Cats; Electrocardiography; Female; Lidocaine; Male; Medulla Oblongata; Midazolam; N-Methylaspartate; Neuropeptides; Oxygen; Periodicity; Phrenic Nerve | 1989 |
Effect of 7-chloro kynurenic acid on glycine modulation of the N-methyl-D-aspartate response in guinea-pig myenteric plexus.
Topics: Animals; Aspartic Acid; Glycine; Guinea Pigs; In Vitro Techniques; Kynurenic Acid; Male; Myenteric Plexus; N-Methylaspartate; Serine | 1989 |
N-methyl-aspartic acid lesions of the arcuate nucleus in adult C57BL/6J mice: a new model for age-related lengthening of the estrous cycle.
Topics: Aging; Animals; Arcuate Nucleus of Hypothalamus; Aspartic Acid; Biogenic Monoamines; Body Weight; Estrogens; Estrus; Female; Hypothalamus; Injections, Subcutaneous; Mice; Mice, Inbred C57BL; Models, Biological; N-Methylaspartate | 1989 |
Excitotoxicity of NMDA and kainic acid is modulated by nigrostriatal dopaminergic fibres.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Corpus Striatum; Dopamine; Glutamate Decarboxylase; Hydroxydopamines; Kainic Acid; N-Methylaspartate; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra | 1989 |
[Excitotoxic damage of the hippocampus in the rat: involvement of N-methyl-D-aspartate receptors].
Topics: Animals; Aspartic Acid; Hippocampus; Illicit Drugs; Kainic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1989 |
Neocortical epileptogenesis in vitro: studies with N-methyl-D-aspartate, phencyclidine, sigma and dextromethorphan receptor ligands.
Topics: Animals; Aspartic Acid; Carbachol; Cerebral Cortex; Dextromethorphan; Dose-Response Relationship, Drug; Epilepsy; In Vitro Techniques; Levorphanol; N-Methylaspartate; Potassium Channels; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1989 |
Inhibition of inositol phospholipid synthesis and norepinephrine-stimulated hydrolysis in rat brain slices by excitatory amino acids.
Topics: Animals; Aspartic Acid; Brain; Brain Mapping; Glutamates; In Vitro Techniques; Inositol; Inositol Phosphates; Male; N-Methylaspartate; Norepinephrine; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Receptors, Adrenergic, alpha | 1989 |
mRNA from NCB-20 cells encodes the N-methyl-D-aspartate/phencyclidine receptor: a Xenopus oocyte expression study.
Topics: Animals; Aspartic Acid; Brain; Cell Line; Evoked Potentials; Female; Hybrid Cells; In Vitro Techniques; N-Methylaspartate; Neuroblastoma; Oocytes; Phencyclidine; Protein Biosynthesis; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; RNA, Messenger; Xenopus | 1989 |
Effects of excitatory amino acid receptor antagonists and agonists on suprachiasmatic nucleus responses to retinohypothalamic tract volleys.
Topics: Animals; Aspartic Acid; Hypothalamus; In Vitro Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Optic Nerve; Pipecolic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Retina; Retinal Ganglion Cells; Suprachiasmatic Nucleus | 1989 |
Modulation of glutamate receptors by phencyclidine and glycine in the rat cerebellum: cGMP increase in vivo.
Topics: Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Brain; Cerebellum; Cyclic GMP; Glycine; Injections, Intraventricular; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Primary afferent excitatory transmission recorded intracellularly in vitro from rat medial vestibular neurons.
Topics: Action Potentials; Animals; Aspartic Acid; Electric Stimulation; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Neurons, Afferent; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Vestibular Nuclei | 1989 |
Synthesis and pharmacology of a series of 3- and 4-(phosphonoalkyl)pyridine- and -piperidine-2-carboxylic acids. Potent N-methyl-D-aspartate receptor antagonists.
Topics: Animals; Aspartic Acid; Binding, Competitive; Biological Assay; Chemical Phenomena; Chemistry; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred DBA; Molecular Conformation; Molecular Structure; N-Methylaspartate; Organophosphorus Compounds; Picolinic Acids; Pipecolic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
In primary cultures of cerebellar granule cells the activation of N-methyl-D-aspartate-sensitive glutamate receptors induces c-fos mRNA expression.
Topics: Animals; Aspartic Acid; Blotting, Northern; Calcium; Cells, Cultured; Cerebellum; Gene Expression Regulation; Glutamates; Glycine; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxadiazoles; Phencyclidine; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Transcription, Genetic | 1989 |
Pharmacological characterization of the glutamate receptor in cultured astrocytes.
Topics: Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Calcium-dependent, slow desensitization distinguishes different types of glutamate receptors.
Topics: Amino Acids; Animals; Aspartic Acid; Cations, Divalent; Chickens; Membrane Potentials; Motor Neurons; N-Methylaspartate; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord | 1989 |
NMDA receptor antagonists that bind to the strychnine-insensitive glycine site and inhibit NMDA-induced Ca2+ fluxes and [3H]GABA release.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Calcium; Desipramine; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Ketamine; Kynurenine; Membranes; N-Methylaspartate; Piperazines; Pyrrolidinones; Radioligand Assay; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
Direct activation of gonadotropin-releasing hormone secretion through different receptors to neuroexcitatory amino acids.
Topics: Animals; Aspartic Acid; Hypothalamus; Kainic Acid; Luteinizing Hormone; Male; N-Methylaspartate; Pituitary Hormone-Releasing Hormones; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Glycine modulation of NMDA-evoked release of [3H]acetylcholine and [3H]dopamine from rat striatal slices.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1989 |
Modulation of NMDA receptor-mediated responses by glycine and D-serine in the rat thalamus in vivo.
Topics: Action Potentials; Animals; Aspartic Acid; Glycine; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Strychnine; Thalamus | 1989 |
N-methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Ethanol; Glycine; Granulocytes; N-Methylaspartate; Osmolar Concentration; Phencyclidine; Picrotoxin | 1989 |
Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage.
Topics: Animals; Aspartic Acid; Calpain; Colchicine; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Peptide Hydrolases; Rats; Rats, Inbred Strains; Spectrin; Time Factors; Tissue Distribution | 1989 |
Pentobarbital-like discriminative stimulus effects of N-methyl-D-aspartate antagonists.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flumazenil; Generalization, Psychological; Male; N-Methylaspartate; Pentobarbital; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Glycine and D-serine act as positive modulators of signal transduction at N-methyl-D-aspartate sensitive glutamate receptors in cultured cerebellar granule cells.
Topics: Animals; Aspartic Acid; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebellum; Glycine; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Serine; Signal Transduction; Strychnine | 1989 |
Calcium influx through N-methyl-D-aspartate channels activates a potassium current in postnatal rat hippocampal neurons.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Cesium; Egtazic Acid; Hippocampus; Membrane Potentials; N-Methylaspartate; Neurons; Potassium; Potassium Channels; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
A phencyclidine recognition site is associated with N-methyl-D-aspartate inhibition of carbachol-stimulated phosphoinositide hydrolysis in rat cortical slices.
Topics: Animals; Aspartic Acid; Carbachol; Cerebral Cortex; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Phencyclidine; Phosphatidylinositols; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists.
Topics: Amino Acids; Animals; Aspartic Acid; Chemical Phenomena; Chemistry; Male; Mice; N-Methylaspartate; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
NMDA receptor antagonists can enhance or impair learning performance in animals.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Gerbillinae; Male; Memory; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Pharmacological profile of NPC 12626, a novel, competitive N-methyl-D-aspartate receptor antagonist.
Topics: Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Brain; Brain Ischemia; Cerebral Ventricles; Corpus Striatum; Electric Conductivity; Female; Gerbillinae; In Vitro Techniques; Male; Membranes; N-Methylaspartate; Oocytes; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Xenopus | 1989 |
Guanine nucleotides are competitive inhibitors of N-methyl-D-aspartate at its receptor site both in vitro and in vivo.
Topics: Animals; Aspartic Acid; Binding, Competitive; Brain; Calcium; Cerebellum; Cerebral Cortex; Cyclic GMP; Cytosol; Guanine Nucleotides; Hippocampus; Intracellular Membranes; Kinetics; Male; N-Methylaspartate; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptosomes | 1989 |
NMDA-coupled and uncoupled forms of the PCP receptor: preliminary in vivo evidence for PCP receptor subtypes.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Harmaline; Ketamine; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Reference Values | 1989 |
MK-801 prevents cognitive and behavioral deficits produced by NMDA receptor overstimulation in the rat hippocampus.
Topics: Animals; Aspartic Acid; Behavior, Animal; Cognition Disorders; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; Male; N-Methylaspartate; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Pulsatile release of gonadotropin-releasing hormone from hypothalamic explants is restrained by blockade of N-methyl-D,L-aspartate receptors.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hypothalamus; Kainic Acid; Magnesium; Male; N-Methylaspartate; Pituitary Hormone-Releasing Hormones; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Beta-N-oxalylamino-L-alanine action on glutamate receptors.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; Aspartic Acid; beta-Alanine; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Oxadiazoles; Piperazines; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synaptic Membranes; Thiocyanates | 1989 |
In vivo modulation of the N-methyl-D-aspartate receptor complex by D-serine: potentiation of ongoing neuronal activity as evidenced by increased cerebellar cyclic GMP.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Cycloserine; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Mice; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1989 |
Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors.
Topics: Animals; Anticonvulsants; Aspartic Acid; Conflict, Psychological; Discrimination Learning; Male; Mice; Mice, Inbred DBA; Motor Activity; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Neurotoxicity of excitatory amino acid receptor agonists in young rat hippocampal slices.
Topics: Animals; Aspartic Acid; Female; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Time Factors | 1989 |
Synthesis and receptor binding studies of (+/-)1-iodo-MK-801.
Topics: Animals; Anticonvulsants; Aspartic Acid; Autoradiography; Brain Chemistry; Dibenzocycloheptenes; Dizocilpine Maleate; Iodine Radioisotopes; Isotope Labeling; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
4-(Phosphonoalkyl)- and 4-(phosphonoalkenyl)-2-piperidinecarboxylic acids: synthesis, activity at N-methyl-D-aspartic acid receptors, and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Aspartic Acid; Chemical Phenomena; Chemistry; Male; Mice; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship | 1989 |
Action of anticonvulsants on hippocampal slices in Mg-free medium.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Epilepsy; Hippocampus; In Vitro Techniques; Magnesium; N-Methylaspartate; Perfusion; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; Dextromethorphan; Dibenzocycloheptenes; Dizocilpine Maleate; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Binding, Competitive; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ketamine; Male; Motor Activity; N-Methylaspartate; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1989 |
Excitatory amino acid binding sites in the rat hippocampus after transient forebrain ischemia.
Topics: Amino Acids; Animals; Aspartic Acid; Binding Sites; Brain Ischemia; Diencephalon; Hippocampus; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Telencephalon | 1989 |
Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-methyl-D-aspartate receptors.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Biological Assay; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; Xenopus laevis | 1989 |
The effect of MK-801 and other antagonists of NMDA-type glutamate receptors on brain-stimulation reward.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ketamine; Kynurenic Acid; Male; N-Methylaspartate; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Self Stimulation | 1989 |
CGS-19755 and MK-801 selectively prevent rat striatal cholinergic and gabaergic neuronal degeneration induced by N-methyl-D-aspartate and ibotenate in vivo.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Cholinergic Fibers; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Ibotenic Acid; Male; N-Methylaspartate; Nerve Degeneration; Oxazoles; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Effects of pentobarbitone, ketamine and lignocaine on synaptic transmission in the rat olfactory cortex in vitro.
Topics: Action Potentials; Animals; Aspartic Acid; Cerebral Cortex; Depression, Chemical; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; In Vitro Techniques; Ketamine; Lidocaine; Male; N-Methylaspartate; Olfactory Pathways; Oxadiazoles; Pentobarbital; Quisqualic Acid; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission | 1989 |
Biochemical evidence for enhanced sensitivity to N-methyl-D-aspartate in the hippocampal formation of kindled rats.
Topics: Animals; Aspartic Acid; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Male; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Inbred Strains | 1989 |
Activation of N-methyl-D-aspartate (NMDA) receptors augments repolarizing responses in lamprey spinal neurons.
Topics: Animals; Aspartic Acid; Fishes; In Vitro Techniques; Lampreys; Membrane Potentials; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1989 |
Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cycloleucine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Hippocampus; Lithium; Male; N-Methylaspartate; Pilocarpine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Status Epilepticus | 1989 |
Anoxia on slow inward currents of immature hippocampal neurons.
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Calcium Channels; Electric Conductivity; Hippocampus; Hypoxia; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains | 1989 |
Effects of competitive and noncompetitive N-methyl-D-aspartate (NMDA) antagonists in rats trained to discriminate NMDA from saline.
Topics: Amino Acids; Animals; Aspartic Acid; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Phenazocine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Glutamate receptor agonists increase the expression of Fos, Fra, and AP-1 DNA binding activity in the mammalian brain.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Blotting, Northern; Convulsants; DNA-Binding Proteins; Electroshock; Gene Expression Regulation; Immunoblotting; Kainic Acid; Male; Mice; Mice, Inbred BALB C; N-Methylaspartate; Nucleic Acid Hybridization; Pentylenetetrazole; Picrotoxin; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Seizures; Transcription Factors | 1989 |
Ca2+-mediated neuronal death in rat brain neuronal cultures by veratridine: protection by flunarizine.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flunarizine; Glutamates; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Rats; Sodium Channels; Tetrodotoxin; Veratridine; Veratrine | 1989 |
Structural requirements for activation of the glycine coagonist site of N-methyl-D-aspartate receptors expressed in Xenopus oocytes.
Topics: Amino Acids; Animals; Aspartic Acid; Binding Sites; Computer Simulation; DNA Mutational Analysis; Dose-Response Relationship, Drug; Glycine; Hydrogen Bonding; Membrane Potentials; Models, Molecular; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Recombinant Proteins; Structure-Activity Relationship; Xenopus laevis | 1989 |
Effects of polyamines on the binding of [3H]MK-801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site.
Topics: Animals; Aspartic Acid; Binding Sites; Brain; Cattle; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; In Vitro Techniques; N-Methylaspartate; Polyamines; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1989 |
Antagonism of monosynaptic excitations in the mouse olfactory cortex slice by 6,7-dinitroquinoxaline-2,3-dione.
Topics: Animals; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Male; Mice; N-Methylaspartate; Oxadiazoles; Pyramidal Tracts; Quinoxalines; Quisqualic Acid; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Reflex, Monosynaptic; Synapses; Synaptic Transmission; Valine | 1989 |
Hippocampal synaptic plasticity induced by excitatory amino acids includes changes in sensitivity to the calcium channel blocker, omega-conotoxin.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium Channel Blockers; Glutamine; Hippocampus; Mollusk Venoms; N-Methylaspartate; Neuronal Plasticity; omega-Conotoxin GVIA; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission; Time Factors | 1989 |
Acute excitotoxicity in chick retina caused by the unusual amino acids BOAA and BMAA: effects of MK-801 and kynurenate.
Topics: Amino Acids, Diamino; Animals; Aspartic Acid; beta-Alanine; Chick Embryo; Cyanobacteria Toxins; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamates; Histocytochemistry; Kynurenic Acid; N-Methylaspartate; Neurons; Neurotoxins; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1989 |
The specific NMDA receptor antagonist AP-7 attenuates focal ischemic brain injury.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Ischemic Attack, Transient; Kinetics; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Abolition of the NMDA-mediated responses by a specific glycine antagonist, 6,7-dichloroquinoxaline-2,3-dione (DCQX).
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Glycine; Kinetics; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; Synaptic Membranes | 1989 |
A quantitative description of excitatory amino acid neurotransmitter responses on cultured embryonic Xenopus spinal neurons.
Topics: Animals; Aspartic Acid; Embryo, Nonmammalian; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Xenopus laevis | 1989 |
Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines.
Topics: Acetamides; Animals; Aspartic Acid; Brain; Calcium; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glycine; In Vitro Techniques; Ketamine; Kinetics; N-Methylaspartate; Phencyclidine; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Properties of excitatory amino acid receptors on sustained ganglion cells in the cat retina.
Topics: Action Potentials; Animals; Aspartic Acid; Cats; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Retina; Retinal Ganglion Cells | 1989 |
Loss of N-methyl-D-aspartate sensitivity of cerebellar Purkinje cells after climbing fiber deafferentation. An in vivo study in the rat.
Topics: Amino Acids; Animals; Aspartic Acid; Male; N-Methylaspartate; Neurotoxins; Olivary Nucleus; Purkinje Cells; Pyridines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
A study of the possible mechanisms underlying the convulsant actions of a linear expanded xanthine.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Convulsants; Evoked Potentials; In Vitro Techniques; Male; N-Methylaspartate; Olfactory Bulb; Pyramidal Tracts; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission; Xanthines | 1989 |
Changes of N-methyl-D-aspartate activated channels of cerebellar granule cells with days in culture.
Topics: Animals; Animals, Newborn; Aspartic Acid; Calcium Channels; Cells, Cultured; Cerebellum; Evoked Potentials; Kinetics; Membrane Potentials; N-Methylaspartate; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Cycloleucine blocks NMDA responses in cultured hippocampal neurones under voltage clamp: antagonism at the strychnine-insensitive glycine receptor.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cycloleucine; Electrophysiology; Female; Hippocampus; Membrane Potentials; N-Methylaspartate; Neurons; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Strychnine | 1989 |
Studies on the role of the NMDA receptor in the substantia nigra pars reticulata and entopeduncular nucleus in the development of the high pressure neurological syndrome in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Atmospheric Pressure; Catalepsy; Globus Pallidus; Male; N-Methylaspartate; Nervous System Diseases; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Substantia Nigra; Syndrome | 1989 |
Effects of an N-methyl-D-aspartate receptor agonist and its antagonist CPP on the levels of dopamine and serotonin metabolites in rat striatum collected in vivo by using a brain dialysis technique.
Topics: Animals; Aspartic Acid; Behavior, Animal; Corpus Striatum; Dopamine; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serotonin | 1989 |
Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker.
Topics: Animals; Aspartic Acid; Cell Membrane; Cerebral Cortex; Dronabinol; Heart Rate; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Stereotyped Behavior; Tremor | 1989 |
Reduced neuroexcitatory effect of domoic acid following mossy fiber denervation of the rat dorsal hippocampus: further evidence that toxicity of domoic acid involves kainate receptor activation.
Topics: Animals; Aspartic Acid; Colchicine; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Pyramidal Tracts; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1989 |
Non-N-methyl-D-aspartate receptors may mediate ipsilateral excitation at lateral superior olivary synapses.
Topics: Acoustic Stimulation; Action Potentials; Animals; Aspartic Acid; Auditory Pathways; Chinchilla; Dose-Response Relationship, Drug; Functional Laterality; Kainic Acid; N-Methylaspartate; Olivary Nucleus; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Kainate evokes the release of endogenous glycine from striatal neurons in primary culture.
Topics: Animals; Aspartic Acid; Cells, Cultured; Corpus Striatum; Glycine; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Glutamate receptor subtypes may be classified into two major categories: a study on Xenopus oocytes injected with rat brain mRNA.
Topics: Animals; Aspartic Acid; Brain Chemistry; Electrophysiology; Glutamates; Homocysteine; Ibotenic Acid; Kainic Acid; Microinjections; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus | 1989 |
Hyperactivity induced by N-methyl-d-aspartate injections into nucleus accumbens: lack of evidence for mediation by dopaminergic neurons.
Topics: Animals; Aspartic Acid; Dopamine; Injections, Intraventricular; Male; Microinjections; Motor Activity; N-Methylaspartate; Neurons; Nucleus Accumbens; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Septal Nuclei | 1989 |
Increased response of cerebellar cGMP to kainate but not NMDA or quisqualate following barbital withdrawal from dependent rats.
Topics: Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Female; Injections, Intraventricular; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Substance-Related Disorders | 1989 |
A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cortical Spreading Depression; Female; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pregnancy; Pyrrolidinones; Quinoxalines; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine | 1989 |
Attenuation of neurotoxicity following anoxia or glutamate receptor activation in EGF- and hippocampal extract-treated neuronal cultures.
Topics: Adenylyl Cyclases; Animals; Aspartic Acid; Cell Differentiation; Cell Survival; Cells, Cultured; Epidermal Growth Factor; Growth Substances; Hippocampus; Hypoxia, Brain; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Oxygen; Potassium Cyanide; Rats; Receptors, Adrenergic, beta; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
The neurobehavioral consequences of N-methyl-D-aspartate (N-MDA) administration in rats.
Topics: Animals; Aspartic Acid; Behavior, Animal; Cerebral Cortex; Choline O-Acetyltransferase; Hippocampus; Male; Memory; Motor Activity; N-Methylaspartate; Pyramidal Tracts; Rats; Rats, Inbred F344 | 1989 |
The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Evoked Potentials; Hippocampus; Hypoxia; In Vitro Techniques; Male; N-Methylaspartate; Neurotoxins; Pyramidal Tracts; Rats; Rats, Inbred Strains; Valine | 1989 |
Bursting induces persistent all-or-none EPSPs by an NMDA-dependent process in piriform cortex.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Aminopyridines; Animals; Aspartic Acid; Cerebral Cortex; Chlorides; In Vitro Techniques; Ketamine; Magnesium; Membrane Potentials; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Time Factors; Valine | 1989 |
Excitatory amino acids inhibit stimulated phosphoinositide hydrolysis in the rat prefrontal cortex.
Topics: Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Cerebral Cortex; Cholera Toxin; Hydrolysis; In Vitro Techniques; Inositol Phosphates; Male; N-Methylaspartate; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Parasympathomimetics; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Sodium; Sugar Phosphates; Virulence Factors, Bordetella | 1989 |
Long-lasting physiological effects of bath applied N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Electric Stimulation; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Spermine; Time Factors; Valine | 1989 |
L-[3H]glutamate binding to a membrane preparation from crayfish muscle.
Topics: Animals; Aspartic Acid; Astacoidea; Binding, Competitive; Calcium; Cell Membrane; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Muscles; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Stereoisomerism | 1989 |
Modulation of dendritic release of dopamine by N-methyl-D-aspartate receptors in rat substantia nigra.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Dendrites; Dopamine; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Kinetics; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Substantia Nigra; Tetrodotoxin | 1989 |
Characterization of L-glutamate action on the release of endogenous dopamine from the rat caudate-putamen.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Caudate Nucleus; Dopamine; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Oxadiazoles; Phenazocine; Potassium; Putamen; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Differential sparing of somatostatin-neuropeptide Y and cholinergic neurons following striatal excitotoxin lesions.
Topics: Animals; Aspartic Acid; Cholinergic Fibers; Corpus Striatum; Dose-Response Relationship, Drug; Kainic Acid; Male; N-Methylaspartate; NADPH Dehydrogenase; Neuropeptide Y; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Somatostatin | 1989 |
A local circuit neocortical synapse that operates via both NMDA and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Dipeptides; Electric Stimulation; Female; Ibotenic Acid; In Vitro Techniques; N-Methylaspartate; Neural Conduction; Oxazoles; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Valine | 1989 |
N-methyl-D-aspartate/glycine and quisqualate/kainate receptors expressed in Xenopus oocytes: antagonist pharmacology.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Kainic Acid; N-Methylaspartate; Oocytes; Quinoxalines; Receptors, AMPA; Receptors, Glycine; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
Effects of nicotinic agonists and antagonists on N-methyl-D-aspartate-induced 3H-norepinephrine release and 3H-(1-[1-(2-thienyl)cyclohexyl]-piperidine) binding in rat hippocampus.
Topics: Animals; Aspartic Acid; Carbachol; Dimethylphenylpiperazinium Iodide; Ganglionic Stimulants; Hexamethonium; Hexamethonium Compounds; Hippocampus; In Vitro Techniques; Mecamylamine; N-Methylaspartate; Nicotine; Norepinephrine; Rats; Receptors, Nicotinic | 1989 |
Pharmacological characterization of voltage-clamped catfish rod horizontal cell responses to kainic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Catfishes; Convulsants; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Photoreceptor Cells; Quisqualic Acid | 1989 |
Evidence for excitatory amino acid transmission between mesencephalic nucleus of V afferents and jaw-closer motoneurons in the guinea pig.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dipeptides; Evoked Potentials; Guinea Pigs; Kynurenic Acid; Male; Masseter Muscle; Mesencephalon; Motor Neurons; N-Methylaspartate; Neurotransmitter Agents; Synapses; Synaptic Transmission; Trigeminal Nuclei; Valine | 1989 |
Effects of a spider toxin (JSTX) on hippocampal CA1 neurons in vitro.
Topics: Action Potentials; Amino Acids; Animals; Arthropod Venoms; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; N-Methylaspartate; Receptors, Amino Acid; Receptors, Cell Surface; Spider Venoms; Time Factors | 1989 |
Cytosolic free calcium and NAD/NADH redox state in the cat cortex during in vivo activation of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cats; Cerebral Cortex; Cytosol; Fluorescent Dyes; In Vitro Techniques; Male; N-Methylaspartate; NAD; Oxidation-Reduction; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
Excitatory amino acid-evoked release of [3H]GABA from hippocampal neurons in primary culture.
Topics: Animals; Aspartic Acid; Cells, Cultured; Ethers; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Ionomycin; Kainic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Veratridine; Zinc | 1989 |
Changes in excitatory amino acid receptor binding in the intact and decorticated rat neostriatum following insulin-induced hypoglycemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Caudate Nucleus; Cerebral Cortex; Corpus Striatum; Frontal Lobe; Glutamates; Glutamic Acid; Hypoglycemia; Ibotenic Acid; Insulin; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Solubilization of quisqualate-sensitive [3H]glutamate binding activity from rat retina.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cell Membrane; Glutamates; Glutamic Acid; Kinetics; Male; N-Methylaspartate; Octoxynol; Oxadiazoles; Polyethylene Glycols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Solubility | 1989 |
Effect of impact trauma on neurotransmitter and nonneurotransmitter amino acids in rat spinal cord.
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Kinetics; Laminectomy; Male; N-Methylaspartate; Neurotransmitter Agents; Rats; Serine; Spinal Cord; Spinal Cord Injuries; Taurine; Threonine | 1989 |
EPSPs in rat neocortical neurons in vitro. II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPs.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Evoked Potentials; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
Regulation of Ca++ influx into striatal neurons by kainic acid.
Topics: Animals; Aspartic Acid; Calcium; Calcium Channels; Corpus Striatum; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Potassium; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium | 1989 |
K+ differentially affects the excitatory amino acids- and carbachol-elicited inositol phosphate formation in rat brain synaptoneurosomes.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Carbachol; Frontal Lobe; Glutamates; Glutamic Acid; Inositol Phosphates; N-Methylaspartate; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Sugar Phosphates; Synaptosomes | 1989 |
6-Cyano-7-nitroquinoxaline-2,3-dione as an excitatory amino acid antagonist in area CA1 of rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Female; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Synapses | 1989 |
Auditory nerve neurotransmitter acts on a kainate receptor: evidence from intracellular recordings in brain slices from mice.
Topics: Action Potentials; Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Mice; Mice, Inbred CBA; N-Methylaspartate; Receptors, Glutamate; Receptors, Neurotransmitter; Vestibulocochlear Nerve | 1989 |
NMDA antagonists block restraint-induced increase in extracellular DOPAC in rat nucleus accumbens.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Carbolines; Convulsants; Diazepam; Male; N-Methylaspartate; Nucleus Accumbens; Phenylacetates; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Restraint, Physical; Riluzole; Septal Nuclei; Thiazoles | 1989 |
Interaction of 6-cyano-7-nitroquinoxaline-2,3-dione with the N-methyl-D-aspartate receptor-associated glycine binding site.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Glycine; N-Methylaspartate; Quinoxalines; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Excitatory amino acid receptors in rat locus coeruleus. An extracellular in vitro study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Glutamates; In Vitro Techniques; Kainic Acid; Locus Coeruleus; Magnesium; Male; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Valine | 1989 |
Conditioned taste aversions induced by phencyclidine and other antagonists of N-methyl-D-aspartate.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Avoidance Learning; Conditioning, Operant; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Taste | 1989 |
NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons.
Topics: Animals; Animals, Newborn; Anticonvulsants; Aspartic Acid; Cells, Cultured; Culture Media; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
The role of excitatory amino acids and NMDA receptors in traumatic brain injury.
Topics: Animals; Aspartic Acid; Binding, Competitive; Brain; Brain Injuries; Dextrorphan; Glutamates; Glutamic Acid; Magnesium; Magnetic Resonance Spectroscopy; Male; N-Methylaspartate; Phosphates; Phosphocreatine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
N-methyl-D-aspartate-sensitive [3H]glutamate binding sites in brain synaptic membranes treated with Triton X-100.
Topics: Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Brain; Glutamates; Glutamic Acid; Kinetics; Kynurenic Acid; N-Methylaspartate; Octoxynol; Polyethylene Glycols; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes; Temperature; Tissue Distribution | 1989 |
Excitatory amino acids enhance dissociation of zinc from soluble protein in cytosol of rat hippocampus.
Topics: Amino Acids; Animals; Aspartic Acid; Cytosol; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nerve Tissue Proteins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Zinc | 1989 |
A slow NMDA-mediated synaptic potential underlies seizures originating from midbrain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Bicuculline; In Vitro Techniques; Inferior Colliculi; N-Methylaspartate; Picrotoxin; Rats; Seizures; Valine | 1989 |
Visual responses in adult cat visual cortex depend on N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Cats; Electric Conductivity; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine; Visual Cortex; Visual Perception | 1989 |
Biochemical characterization of an autoradiographic method for studying excitatory amino acid receptors using L-[3H]glutamate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Binding, Competitive; Brain; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Software; Tritium | 1989 |
CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) antagonizes NMDA-evoked [3H]GABA release from cultured cortical neurons via an inhibitory action at the strychnine-insensitive glycine site.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
Characterization of deep dorsal horn neurones in the rat spinal cord in vitro: synaptic and excitatory amino acid induced excitations.
Topics: Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Spinal Cord; Synapses | 1989 |
Extracellular concentrations of aspartate and glutamate in rat neostriatum following chemical stimulation of frontal cortex.
Topics: Animals; Aspartic Acid; Bicuculline; Corpus Striatum; Frontal Lobe; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neural Pathways; Rats; Rats, Inbred Strains | 1989 |
Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Biological Transport; Calcium; Cell Survival; Cells, Cultured; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Protein Kinase C; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Transient increase of NMDA-binding sites in human hippocampus during development.
Topics: Adult; Aging; Aspartic Acid; Fetus; Glutamates; Glutamic Acid; Hippocampus; Humans; Infant; Infant, Newborn; Middle Aged; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Selective effects of serotonin upon excitatory amino acid-induced depolarizations of Purkinje cells in cerebellar slices from young rats.
Topics: Action Potentials; Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Serotonin | 1989 |
[Analysis of the effect of quisqualate, N-methyl-D- aspartate and several blockers of amino acid receptors on synaptic transmission in the ampullae of Lorenzini].
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Aminobutyrates; Animals; Aspartic Acid; Electric Fish; Evoked Potentials; Magnesium; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sensory Receptor Cells; Skates, Fish; Synapses; Synaptic Transmission; Valine | 1989 |
Developmental changes in the chemosensitivity of rat brain synaptoneurosomes to excitatory amino acids, estimated by inositol phosphate formation.
Topics: Aging; Animals; Aspartic Acid; Carbachol; Female; Frontal Lobe; Glutamates; Glutamic Acid; Inositol Phosphates; Male; N-Methylaspartate; Norepinephrine; Oxadiazoles; Quisqualic Acid; Rats; Sugar Phosphates; Synaptosomes | 1989 |
Glycine potentiates the stimulation of inositol phospholipid hydrolysis by excitatory amino acids in primary cultures of cerebellar neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Drug Synergism; Glutamates; Glutamic Acid; Glycine; Hydrolysis; Inositol Phosphates; Magnesium; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Signal Transduction; Sugar Phosphates | 1989 |
Delayed rescue of N-methyl-D-aspartate receptor-mediated neuronal injury in cortical culture.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Valine | 1989 |
Glycine potentiates NMDA responses in rat hippocampal CA1 neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Glycine; Hippocampus; Humans; N-Methylaspartate; Rats; Valine | 1989 |
NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Valine | 1989 |
Glutamate receptor activation in cultured cerebellar granule cells increases cytosolic free Ca2+ by mobilization of cellular Ca2+ and activation of Ca2+ influx.
Topics: Animals; Aspartic Acid; Benzofurans; Calcium; Calcium Channel Blockers; Cells, Cultured; Cerebellum; Cytosol; Fluorescent Dyes; Fura-2; Glutamates; Glutamic Acid; Inositol Phosphates; Kainic Acid; Mice; N-Methylaspartate; Receptors, Glutamate; Receptors, Neurotransmitter; Spectrometry, Fluorescence | 1989 |
Effects of excitant amino acids on acoustic responses of inferior colliculus neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Inferior Colliculi; N-Methylaspartate; Parasympathomimetics; Rats; Rats, Inbred Strains; Valine | 1989 |
Actions of excitatory amino acids on somatostatin release from cortical neurons in primary cultures.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Fetus; Glutamates; Glutamic Acid; Glutamine; Glycine; Kinetics; Magnesium; N-Methylaspartate; Neurons; Neurotransmitter Agents; Rats; Somatostatin; Tetrodotoxin; Veratridine | 1989 |
A grease-gap method for studying the excitatory amino acid pharmacology of CA1 hippocampal pyramidal cells.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Electrophysiology; Female; Glutamates; Hippocampus; Ibotenic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Phencyclidine; Rats; Rats, Inbred Strains; Valine | 1989 |
Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Electrophysiology; Glutamates; Glycine; Hippocampus; Histocytochemistry; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
NMDA antagonists and potentiation of NMDA-induced motoneuron depolarizations in the isolated frog spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Evoked Potentials; Ketamine; Kynurenic Acid; Magnesium; Motor Neurons; N-Methylaspartate; Potassium; Rana pipiens; Spinal Cord; Valine | 1989 |
Is L-glutamate a neurotransmitter of baroreceptor information in the nucleus of the tractus solitarius?
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Blood Pressure; Electric Stimulation; Female; Glutamates; Heart Rate; Ibotenic Acid; Kynurenic Acid; Medulla Oblongata; N-Methylaspartate; Neurotransmitter Agents; Pressoreceptors; Rats; Reflex; Sensory Receptor Cells; Xanthurenates | 1989 |
NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus.
Topics: Action Potentials; Animals; Aspartic Acid; Electric Conductivity; Glutamates; Hippocampus; N-Methylaspartate; Neurotransmitter Agents; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission; Tetrodotoxin | 1989 |
Lack of excitatory amino acid-induced effects on calcium fluxes measured with 45Ca2+ in rat cerebral cortex synaptosomes.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Calcium Radioisotopes; Cerebral Cortex; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Magnesium; Male; N-Methylaspartate; Potassium; Rats; Rats, Inbred Strains; Synaptosomes; Temperature | 1989 |
Pentylenetetrazol kindling in mice.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Cannabidiol; Electric Stimulation; Kindling, Neurologic; Male; Mice; N-Methylaspartate; Neurotransmitter Agents; Pentylenetetrazole; Picrotoxin | 1989 |
L-homocysteic acid--a possible bipolar cell transmitter in the rabbit retina.
Topics: Acetylcholine; Animals; Aspartic Acid; Cholinergic Fibers; Homocysteine; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Agents; Photic Stimulation; Rabbits; Retina | 1989 |
Extracellular taurine increase in rat hippocampus evoked by specific glutamate receptor activation is related to the excitatory potency of glutamate agonists.
Topics: Action Potentials; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Coexistence of NMDA and non-NMDA receptors on turtle horizontal cells revealed using isolated retina preparations.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Evoked Potentials, Visual; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Turtles; Valine | 1989 |
Effects of amygdaloid kindling on NMDA receptor function and regulation.
Topics: Amygdala; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kindling, Neurologic; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Multiple effects of phorbol esters in the rat spinal dorsal horn.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Calcium; Colforsin; Drug Synergism; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Phorbol Esters; Rats; Rats, Inbred Strains; Sodium; Spinal Cord; Synapses; Synaptic Transmission | 1989 |
Quantitative physiological characterization of a quinoxalinedione non-NMDA receptor antagonist.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Hippocampus; Kainic Acid; Mathematics; N-Methylaspartate; Neurons; Oxadiazoles; Quinoxalines; Quisqualic Acid; Synapses | 1989 |
Inhibition of rat brain glutamate receptors by philanthotoxin.
Topics: Animals; Aspartic Acid; Bee Venoms; Brain; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Wasp Venoms; Xenopus | 1989 |
Dilator effects of amino acid neurotransmitters on piglet pial arterioles.
Topics: 6-Ketoprostaglandin F1 alpha; Amino Acids; Animals; Arteries; Arterioles; Aspartic Acid; Blood Pressure; Cerebrovascular Circulation; Dinoprostone; Female; Glutamates; Glutamic Acid; Glycine; Isoproterenol; Male; Muscle, Smooth, Vascular; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Pia Mater; Reference Values; Swine; Taurine | 1989 |
Ethanol inhibits NMDA-induced increases in free intracellular Ca2+ in dissociated brain cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Brain; Calcium; Cell Separation; Ethanol; Fluorescent Dyes; In Vitro Techniques; Magnesium; N-Methylaspartate; Rats; Rats, Inbred Strains | 1989 |
HA-966 acts at a modulatory glycine site to inhibit N-methyl-D-aspartate-evoked neurotransmitter release.
Topics: Animals; Aspartic Acid; Binding Sites; Dibenzocycloheptenes; Dizocilpine Maleate; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Piperazines; Pyrrolidinones; Rats; Strychnine | 1989 |
Inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in the neonatal rat hippocampus by 2-amino-3-phosphonopropionate.
Topics: Alanine; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Carbachol; Chlorides; Hippocampus; Hydrolysis; Ibotenic Acid; In Vitro Techniques; Inositol; Kainic Acid; Kinetics; Lithium; Lithium Chloride; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains | 1989 |
Glutamate receptors of the N-methyl-D-aspartate subtype in the myenteric plexus of the guinea pig ileum.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Guinea Pigs; Ileum; Magnesium; Male; Muscle Contraction; Myenteric Plexus; N-Methylaspartate; Piperazines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Penicillin-induced bursting in motoneurones of the frog spinal cord. Elimination by NMDA antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Evoked Potentials; In Vitro Techniques; Membrane Potentials; Motor Neurons; N-Methylaspartate; Penicillins; Rana ridibunda; Spinal Cord | 1989 |
Excitatory amino acid receptor-mediated activation of solitarial deglutitive loci.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Deglutition; Dipeptides; Esophagus; Glutamates; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Oxadiazoles; Pharynx; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Different modulation of the binding to two phencyclidine (PCP) receptor subtypes: effects of N-methyl-D-aspartate agonists and antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Glutamates; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Different classes of glutamate receptors mediate distinct behaviors in a single brainstem nucleus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Brain Stem; Electric Fish; Electric Organ; Glutamates; Glutamic Acid; Glutamine; Kainic Acid; N-Methylaspartate; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
Topics: Animals; Arginine; Aspartic Acid; Cerebellum; Citrulline; Cyclic GMP; Glutamates; Glutamic Acid; Hemoglobins; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Quisqualic Acid; Rats | 1989 |
A biochemical correlate of the critical period for synaptic modification in the visual cortex.
Topics: Aging; Animals; Aspartic Acid; Carbachol; Cattle; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methylaspartate; Ocular Physiological Phenomena; Phosphatidylinositols; Synapses; Vision, Ocular; Visual Cortex | 1989 |
Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Algorithms; Animals; Aspartic Acid; Extracellular Space; Glutamates; Glutamic Acid; Hippocampus; Least-Squares Analysis; Magnesium; Microelectrodes; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1989 |
N-methyl-D-aspartate antagonists prevent interaction of binocular maps in Xenopus tectum.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Functional Laterality; N-Methylaspartate; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Regression Analysis; Superior Colliculi; Visual Fields; Xenopus | 1989 |
N-methyl-D-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis and Papio papio).
Topics: Animals; Aspartic Acid; Binding, Competitive; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Hippocampus; N-Methylaspartate; Papio; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Pharmacology of calcium-induced long-term potentiation in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Atropine; Calcium; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Propranolol; Rats; Rats, Inbred Strains; Verapamil | 1989 |
Convulsions induced by centrally administered NMDA in mice: effects of NMDA antagonists, benzodiazepines, minor tranquilizers and anticonvulsants.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Aspartic Acid; Benzodiazepines; Binding, Competitive; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Seizures | 1989 |
Inhibition of N-methyl-D-aspartate- and kainic acid-induced neurotransmitter release by omega-conotoxin GVIA.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mollusk Venoms; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; omega-Conotoxin GVIA; Rats; Rats, Inbred Strains | 1989 |
Respiratory effects of N-methyl-D-aspartate on the ventrolateral medullary surface.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Blood Pressure; Carbon Dioxide; Carotid Sinus; Cats; Female; Male; Medulla Oblongata; N-Methylaspartate; Phrenic Nerve; Respiration; Tidal Volume; Vagotomy | 1989 |
Selective inhibition of excitatory amino acids by divalent cations. A novel means for distinguishing N-methyl-D-aspartic acid-, kainate- and quisqualate-mediated actions in the mouse spinal cord.
Topics: Animals; Aspartic Acid; Behavior, Animal; Calcium; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; Male; Mice; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Spinal Cord; Zinc | 1989 |
Glial uptake of excitatory amino acids influences neuronal survival in cultures of mouse hippocampus.
Topics: Action Potentials; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Culture Media; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroglia; Phosphopyruvate Hydratase; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Inhibition of N-methyl-D-aspartate (NMDA)- and L-glutamate-induced noradrenaline and acetylcholine release in the rat brain by ethanol.
Topics: Acetylcholine; Animals; Aspartic Acid; Calcium; Cerebral Cortex; Choline; Corpus Striatum; Ethanol; Glutamates; Glutamic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Tritium; Veratridine | 1989 |
Cerebellar granule cell survival and maturation induced by K+ and NMDA correlate with c-fos proto-oncogene expression.
Topics: Animals; Aspartic Acid; Cell Survival; Cerebellum; Glutamates; Glutamic Acid; Mice; N-Methylaspartate; Potassium; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Quisqualate and N-methyl-D-aspartate synergistically excite cerebellar Purkinje cells as a long-term effect.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Female; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats | 1989 |
Bicuculline- and phaclofen-sensitive components of N-methyl-D-aspartate-induced hyperpolarizations in rat dorsolateral septal nucleus neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Baclofen; Bicuculline; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Septal Nuclei; Tetrodotoxin | 1989 |
Excitatory amino acids mediate responses elicited in vitro by stimulation of cortical afferents to reticularis thalami neurons of the rat.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; N-Methylaspartate; Rats; Rats, Inbred Strains; Thalamus | 1989 |
Traumatic neuronal injury in vitro is attenuated by NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Dextrorphan; Mice; Morphinans; N-Methylaspartate; Nerve Tissue; Neuroglia; Neurons; Stress, Mechanical | 1989 |
NMDA receptor antagonists disrupt the retinotectal topographic map.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anura; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells; Superior Colliculi | 1989 |
The effects of potassium channel blocking agents on the responses of in vitro frog motoneurones to glutamate and other excitatory amino acids: an intracellular study.
Topics: Amino Acids; Animals; Aspartic Acid; Cell Membrane; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Ion Channels; N-Methylaspartate; Oxadiazoles; Potassium; Quisqualic Acid; Rana temporaria; Spinal Cord | 1985 |
The action of N-methyl-D-aspartic acid on mouse spinal neurones in culture.
Topics: Action Potentials; Animals; Aspartic Acid; Cells, Cultured; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Spinal Cord; Time Factors | 1985 |
Excitatory amino acid-induced responses of frog motoneurones bathed in low Na+ media: an intracellular study.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Ion Channels; Membrane Potentials; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana temporaria; Sodium; Spinal Cord | 1985 |
Endogenous and network bursts induced by N-methyl-D-aspartate and magnesium free medium in the CA3 region of the hippocampal slice.
Topics: Animals; Aspartic Acid; Culture Media; Dendrites; Electrophysiology; Hippocampus; In Vitro Techniques; Magnesium; N-Methylaspartate; Nerve Net; Nervous System; Neurons; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Tricyclic antidepressants block N-methyl-D-aspartic acid-induced lethality in mice.
Topics: Animals; Antidepressive Agents, Tricyclic; Aspartic Acid; Male; Mice; N-Methylaspartate | 1989 |
The mechanism of action and pharmacological specificity of the anticonvulsant NMDA antagonist MK-801: a voltage clamp study on neuronal cells in culture.
Topics: Acetylcholine; Animals; Anticonvulsants; Aspartic Acid; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Stimulation; Evoked Potentials; Hippocampus; Ketamine; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1989 |
Homocysteic acid: convulsant action of stereoisomers in mice.
Topics: Animals; Aspartic Acid; Convulsants; Homocysteine; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Seizures; Stereoisomerism | 1989 |
Qualitative changes in luteinizing hormone and prolactin responses to N-methyl-aspartic acid during lactation in the rat.
Topics: Animals; Aspartic Acid; Female; Hypothalamus; Lactation; Luteinizing Hormone; Male; N-Methylaspartate; Pituitary Hormone-Releasing Hormones; Pregnancy; Prolactin; Rats; Rats, Inbred Strains; Sex Factors | 1989 |
Puberty in monkeys is triggered by chemical stimulation of the hypothalamus.
Topics: Animals; Aspartic Acid; Electric Stimulation; Gonadotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Hypothalamus; Macaca mulatta; Male; N-Methylaspartate; Orchiectomy; Reference Values; Sexual Maturation; Testis | 1989 |
Low doses of accumbens dopamine modulate amygdala suppression of spontaneous exploratory activity in rats.
Topics: Amygdala; Animals; Aspartic Acid; Dopamine; Drug Interactions; Excitatory Amino Acid Antagonists; Exploratory Behavior; Glutamates; Male; Microinjections; Motor Activity; N-Methylaspartate; Nipecotic Acids; Nucleus Accumbens; Rats; Rats, Inbred Strains; Reference Values; Septal Nuclei | 1989 |
Effects of phencyclidine and other N-methyl-D-aspartate antagonists on the schedule-controlled behavior of rats.
Topics: Animals; Aspartic Acid; Conditioning, Psychological; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperazines; Piperidines; Punishment; Rats; Rats, Inbred Strains; Reinforcement Schedule; Stereoisomerism | 1989 |
The role of spinal cord inputs in modulating the activity of reticulospinal neurons during fictive locomotion in the lamprey.
Topics: Action Potentials; Animals; Aspartic Acid; Brain Stem; Chlorides; Fishes; Lampreys; Locomotion; N-Methylaspartate; Spinal Cord | 1989 |
Lateral geniculate lesions alter circadian activity rhythms in the hamster.
Topics: Animals; Aspartic Acid; Circadian Rhythm; Cricetinae; Geniculate Bodies; Male; Motor Activity; N-Methylaspartate; Neuropeptide Y | 1989 |
N-methyl-D-aspartate induces recurrent synchronized burst activity in immature hippocampal CA3 neurones in vitro.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Female; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Tetrodotoxin | 1989 |
The competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 attenuates the rate-decreasing effects of NMDA in rhesus monkeys without producing ketamine-like discriminative stimulus effects.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Ketamine; Macaca mulatta; Male; N-Methylaspartate; Pipecolic Acids; Piperidines | 1989 |
GABAergic neocortical neurons are resistant to NMDA receptor-mediated injury.
Topics: Animals; Aspartic Acid; Autoradiography; Cell Count; Cell Survival; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Immunohistochemistry; N-Methylaspartate; Neurons | 1989 |
Selective depression of N-methyl-D-aspartate-mediated responses by dextrorphan in the hippocampal slice in rat.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dextrorphan; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; In Vitro Techniques; Magnesium; Male; Morphinans; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1989 |
Glycine reverses the effect of HA-966 on NMDA responses in cultured rat cortical neurons and in chick retina.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Chickens; Cortical Spreading Depression; Glycine; In Vitro Techniques; N-Methylaspartate; Neurons; Pyrrolidinones; Rats; Retina | 1989 |
Interhemispheric relationship between lateral hypothalamic self-stimulation and the region of the nucleus tegmenti pedunculo-pontinus.
Topics: Animals; Aspartic Acid; Electric Stimulation; Functional Laterality; Hypothalamic Area, Lateral; Male; N-Methylaspartate; Pons; Rats; Rats, Inbred Strains; Self Stimulation | 1989 |
Anticonvulsant activities of 1-phenylcyclohexylamine and its conformationally restricted analog 1,1-pentamethylenetetrahydroisoquinoline.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Cyclohexylamines; Isoquinolines; Male; Mice; Motor Activity; N-Methylaspartate; Phencyclidine; Seizures; Tetrahydroisoquinolines | 1989 |
N-methyl-d, l-aspartate stimulates growth hormone but not luteinizing hormone secretion in the sheep.
Topics: Animals; Aspartic Acid; Growth Hormone; Kinetics; Luteinizing Hormone; Male; N-Methylaspartate; Orchiectomy; Sheep | 1989 |
Interactions between the amygdala and ventral striatum in stimulus-reward associations: studies using a second-order schedule of sexual reinforcement.
Topics: Amphetamines; Amygdala; Animals; Aspartic Acid; Corpus Striatum; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Neurotoxins; Rats; Reward; Sexual Behavior, Animal | 1989 |
Involvement of the amygdala in stimulus-reward associations: interaction with the ventral striatum.
Topics: Amphetamines; Amygdala; Animals; Aspartic Acid; Conditioning, Classical; Corpus Striatum; Dopamine; Drinking Behavior; Male; N-Methylaspartate; Neurotoxins; Rats; Rats, Inbred Strains; Reward | 1989 |
The interaction of beta-N-methylamino-L-alanine with bicarbonate: an 1H-NMR study.
Topics: Amino Acids, Diamino; Aspartic Acid; Bicarbonates; Chemical Phenomena; Chemistry; Cyanobacteria Toxins; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Structure; N-Methylaspartate | 1989 |
Absence of P2-purinoceptors in hippocampal pathways.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Aspartic Acid; Carbachol; Hippocampus; In Vitro Techniques; Iontophoresis; Male; N-Methylaspartate; Neural Pathways; Pyramidal Tracts; Rats; Receptors, Purinergic | 1989 |
Neuroprotective effects of MK-801, TCP, PCP and CPP against N-methyl-D-aspartate induced neurotoxicity in an in vivo perinatal rat model.
Topics: Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Female; Male; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains | 1989 |
Increase in endogenous 5-hydroxytryptamine levels modulates the central network underlying locomotion in the lamprey spinal cord.
Topics: Action Potentials; Animals; Aspartic Acid; Citalopram; Fishes; In Vitro Techniques; Lampreys; Locomotion; N-Methylaspartate; Serotonin; Spinal Cord | 1989 |
Spontaneous epileptiform activity and alteration of GABA- and of NMDA-mediated neurotransmission in amygdala neurons kindled in vivo.
Topics: Animals; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; In Vitro Techniques; Kindling, Neurologic; Male; N-Methylaspartate; Rats | 1989 |
Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity.
Topics: Air Pressure; Animals; Animals, Newborn; Aspartic Acid; Atmospheric Pressure; Brain; Brain Ischemia; Disease Susceptibility; Microinjections; N-Methylaspartate; Nerve Degeneration; Neurons; Rats; Rats, Inbred Strains | 1989 |
Augmentation of glutamate responses by GABA in the rat's motorcortex in vivo.
Topics: Animals; Aspartic Acid; Baclofen; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Motor Cortex; Muscimol; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats | 1989 |
Protective effect of N-methyl-D-aspartate antagonists after focal cerebral ischemia in rabbits.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dextromethorphan; Dextrorphan; Ischemic Attack, Transient; Levorphanol; Magnetic Resonance Imaging; Male; Morphinans; N-Methylaspartate; Neurons; Rabbits | 1989 |
Excitotoxin-induced lesions of the central but not basolateral nucleus of the amygdala modulate the baroreceptor heart rate reflex in conscious rats.
Topics: Amygdala; Animals; Aspartic Acid; Cardiovascular Physiological Phenomena; Heart Rate; Male; N-Methylaspartate; Neurotoxins; Pressoreceptors; Rats; Rats, Inbred Strains | 1989 |
Antitussive agents as N-methylaspartate antagonists: further studies.
Topics: Animals; Antitussive Agents; Aspartic Acid; Injections, Intravenous; Iontophoresis; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains | 1989 |
Development of N-methyl-D-aspartate excitotoxicity in cultured hippocampal neurons.
Topics: Age Factors; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Embryo, Mammalian; Hippocampus; N-Methylaspartate; Neurotoxins; Rats; Rats, Inbred Strains | 1989 |
Effect of the NMDA antagonist MK-801 on local cerebral blood flow in focal cerebral ischaemia in the rat.
Topics: Animals; Aspartic Acid; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Rats; Rats, Inbred Strains | 1989 |
In vivo electrochemical studies of the effects of N-methyl-D-aspartate (NMDA) on dopamine nerve terminals in the neostriatum of the anesthetized rat.
Topics: Anesthesia; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Electrochemistry; Kainic Acid; Male; N-Methylaspartate; Nerve Endings; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1989 |
Excitatory amino acids interfere with normal eye growth in posthatch chick.
Topics: Animals; Anterior Chamber; Aspartic Acid; Chickens; Eye; Kainic Acid; N-Methylaspartate; Organ Size; Oxadiazoles; Quisqualic Acid; Retina; Time Factors | 1989 |
Non-competitive N-methyl-D-aspartate antagonists protect against sound-induced seizures in DBA/2 mice.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Body Temperature; Female; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Seizures; Time Factors | 1989 |
Concanavalin A potentiates NMDA-evoked responses in the Xenopus oocyte expression system.
Topics: Animals; Aspartic Acid; Brain; Concanavalin A; Drug Synergism; Gene Expression Regulation; Glycine; In Vitro Techniques; N-Methylaspartate; Oocytes; RNA, Messenger; Stimulation, Chemical; Xenopus | 1989 |
Regulation of dopamine function in the nucleus accumbens of the rat by the thalamic paraventricular nucleus and adjacent midline nuclei.
Topics: Animals; Aspartic Acid; Dopamine; Electric Stimulation; Injections, Intraventricular; Male; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Septal Nuclei; Thalamic Nuclei | 1989 |
Inhibitory postsynaptic potentials in neonatal rat sympathetic preganglionic neurones in vitro.
Topics: Animals; Animals, Newborn; Aspartic Acid; Autonomic Fibers, Preganglionic; Evoked Potentials; Membrane Potentials; N-Methylaspartate; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine; Tetrodotoxin | 1989 |
Glycine potentiates the NMDA-induced release of dopamine through a strychnine-insensitive site in the rat striatum.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Drug Synergism; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Strychnine | 1989 |
Excitotoxin-induced myocardial necrosis.
Topics: Animals; Aspartic Acid; Blood Pressure; Cardiomyopathies; Heart Rate; Hypothalamus, Middle; Injections; Injections, Intraventricular; Kainic Acid; Male; Myocardium; N-Methylaspartate; Necrosis; Rats; Rats, Inbred Strains | 1989 |
Kynurenic acid microinjected into the nucleus tractus solitarius of rat blocks the arterial baroreflex but not responses to glutamate.
Topics: Acetylcholine; Animals; Arteries; Aspartic Acid; Blood Pressure; Excitatory Amino Acid Antagonists; Glutamates; Histocytochemistry; Kainic Acid; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; N-Methylaspartate; Oxadiazoles; Pressoreceptors; Quisqualic Acid; Rats; Rats, Inbred Strains; Reflex | 1989 |
HA-966 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-D-aspartate (NMDA)-mediated brain damage.
Topics: Animals; Animals, Newborn; Aspartic Acid; Brain Diseases; Corpus Striatum; N-Methylaspartate; Oxadiazoles; Pyrrolidinones; Quisqualic Acid; Rats; Rats, Inbred Strains | 1989 |
Infusion of NMDA into the nucleus basalis of Meynert, frontal cortex or lateral ventricle in rats: effect on memory and cholinergic brain neurochemistry.
Topics: Acetylcholinesterase; Animals; Aspartic Acid; Avoidance Learning; Basal Ganglia; Brain Chemistry; Cerebral Cortex; Cerebral Ventricles; Choline O-Acetyltransferase; Hippocampus; Male; Memory; N-Methylaspartate; Rats; Rats, Inbred Strains; Substantia Innominata | 1989 |
Metabolic action of N-methyl-D-aspartate in newborn rat brain ex vivo: 31p magnetic resonance spectroscopy.
Topics: Animals; Animals, Newborn; Aspartic Acid; Atractyloside; Brain; Brain Stem; Electrophysiology; In Vitro Techniques; Magnetic Resonance Spectroscopy; N-Methylaspartate; Neurons; Neurotoxins; Phosphorus; Potassium; Rats; Rats, Inbred Strains | 1989 |
Pretreatment with the NMDA antagonist dextrorphan reduces cerebral injury following transient focal ischemia in rabbits.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Cerebral Cortex; Dextrorphan; Ischemic Attack, Transient; Magnetic Resonance Spectroscopy; Male; Morphinans; N-Methylaspartate; Neurons; Rabbits | 1989 |
Blockade of N-methyl-D-aspartate induced convulsions by 1-aminocyclopropanecarboxylates.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Anticonvulsants; Aspartic Acid; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Inbred Strains; Strychnine; Synaptic Membranes | 1989 |
Calcium dependency of N-methyl-D-aspartate toxicity in slices from the immature rat hippocampus.
Topics: Animals; Aspartic Acid; Brain Edema; Calcium; Female; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurotoxins; Rats; Rats, Inbred Strains | 1989 |
Quantitative assessment of neuroprotection against NMDA-induced brain injury.
Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Choline O-Acetyltransferase; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Ketamine; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Regression Analysis | 1989 |
Strychnine-insensitive binding of [3H]glycine to synaptic membranes in rat brain, treated with Triton X-100.
Topics: Animals; Aspartic Acid; Brain Chemistry; Glycine; In Vitro Techniques; Kinetics; N-Methylaspartate; Octoxynol; Polyethylene Glycols; Rats; Rats, Inbred Strains; Strychnine; Synaptic Membranes | 1989 |
Effect of the NMDA antagonist MK-801 on MPTP-induced parkinsonism in the monkey.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Injections, Intramuscular; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; N-Methylaspartate; Parkinson Disease, Secondary | 1989 |
Drug discrimination based on the competitive N-methyl-D-aspartate antagonist, NPC 12626.
Topics: Amino Acids; Animals; Aspartic Acid; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Pentobarbital; Phencyclidine; Rats; Rats, Inbred Strains | 1989 |
1-Hydroxy-3-aminopyrrolid-2-one (HA-966) and kynurenate antagonize N-methyl-D-aspartate induced enhancement of [3H]dopamine release from rat striatal slices.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Drug Antagonism; Kynurenic Acid; Male; N-Methylaspartate; Potassium; Pyrrolidinones; Rats; Rats, Inbred Strains | 1989 |
Comparison of behavioral effects of nucleus basalis magnocellularis lesions and somatosensory cortex ablation in the rat.
Topics: Animals; Aspartic Acid; Basal Ganglia; Behavior, Animal; Cholinergic Fibers; Discrimination Learning; Emotions; Male; Memory; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Inbred Strains; Somatosensory Cortex | 1989 |
Estrogen administration increases neuronal responses to excitatory amino acids as a long-term effect.
Topics: Action Potentials; Animals; Aspartic Acid; Estradiol; Female; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats | 1989 |
Effects of N-methyl-D-aspartate antagonists on the cough reflex.
Topics: Animals; Anticonvulsants; Aspartic Acid; Capsaicin; Cough; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Reflex | 1989 |
Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord.
Topics: Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Aspartic Acid; Dose-Response Relationship, Drug; Electrophysiology; Glutamates; Molecular Conformation; Motor Neurons; N-Methylaspartate; Rats; Rats, Inbred Strains; Spinal Cord; Stereoisomerism | 1989 |
Effect of glycine and glycine receptor antagonists on NMDA-induced brain injury.
Topics: Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Glycine; Kynurenic Acid; N-Methylaspartate; Organ Size; Rats; Rats, Inbred Strains | 1989 |
Selective modulation of NMDA responses by reduction and oxidation.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Chickens; Dithionitrobenzoic Acid; Dithiothreitol; Fetus; Membrane Potentials; N-Methylaspartate; Neurons; Oxidation-Reduction; Rats; Retina; Retinal Ganglion Cells; Zinc | 1989 |
AMPA, kainic acid, and N-methyl-D-aspartic acid stimulate locomotor activity after injection into the substantia innominata/lateral preoptic area.
Topics: 2-Aminoadipic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Basal Ganglia; Dose-Response Relationship, Drug; Drug Interactions; Glutamine; Ibotenic Acid; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Oxazoles; Preoptic Area; Quinoxalines; Rats; Rats, Inbred Strains; Substantia Innominata | 1989 |
A novel NMDA antagonist, MK-801, impairs performance in a hippocampal-dependent spatial learning task.
Topics: Animals; Aspartic Acid; Behavior, Animal; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraperitoneal; Learning; Male; Memory; Motor Activity; N-Methylaspartate; Rats | 1989 |
Systemically administered N-methyl-D-aspartate interferes with acquisition of a passive avoidance response in rats.
Topics: Animals; Aspartic Acid; Avoidance Learning; Dose-Response Relationship, Drug; Male; Memory; N-Methylaspartate; Rats; Rats, Inbred Strains; Retention, Psychology; Time Factors | 1989 |
The effects of N-methyl-D-aspartate antagonists on the development of vestibular compensation in the guinea pig.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Ear, Inner; Guinea Pigs; In Vitro Techniques; N-Methylaspartate; Nystagmus, Physiologic; Piperazines; Vestibule, Labyrinth | 1989 |
2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum; Cyclic GMP; Female; N-Methylaspartate; Rats; Rats, Inbred Strains; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1987 |
Cultured cerebellar cells as an in vitro model of excitatory amino acid receptor function.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Cyclic GMP; Kainic Acid; Models, Neurological; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1987 |
The role of N-methylaspartate receptors in mediating responses of rat and cat spinal neurones to defined sensory stimuli.
Topics: Action Potentials; Animals; Anticonvulsants; Aspartic Acid; Cats; Female; Interneurons; Ketamine; Male; Methohexital; Motor Neurons; N-Methylaspartate; Neurons; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex, Monosynaptic; Spinal Cord | 1987 |
Quantitative autoradiographic localization of NMDA receptors in rat brain using [3H]CPP: comparison with [3H]TCP binding sites.
Topics: Animals; Aspartic Acid; Autoradiography; Brain; Brain Chemistry; In Vitro Techniques; Ligands; Male; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.
Topics: Animals; Aspartic Acid; Enkephalins; Hot Temperature; Kainic Acid; Male; Mice; N-Methylaspartate; Narcotics; Nociceptors; Oxadiazoles; Pain; Phencyclidine; Phentolamine; Quisqualic Acid; Receptors, Opioid; Receptors, sigma; Spinal Cord | 1987 |
Voltage clamp analysis of lamprey neurons--role of N-methyl-D-aspartate receptors in fictive locomotion.
Topics: Action Potentials; Animals; Aspartic Acid; In Vitro Techniques; Lampreys; Locomotion; Membrane Potentials; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Strychnine; Tetraethylammonium Compounds; Tetrodotoxin | 1987 |
Functional and biochemical characteristics of a putative quisqualate-type receptor in rat striatum: effect of brain lesions.
Topics: Animals; Aspartic Acid; Brain; Cerebral Cortex; Convulsants; Corpus Striatum; Dopamine; Glutamates; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug | 1986 |
Antagonism of N-methyl-D-aspartate (NMDA) evoked increases in cerebellar cGMP and striatal ACh release by phencyclidine (PCP) receptor agonists: evidence for possible allosteric coupling of NMDA and PCP receptors.
Topics: Acetylcholine; Animals; Aspartic Acid; Brain Chemistry; Cerebellum; Corpus Striatum; Cyclic GMP; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; N-Methylaspartate; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1987 |
Anti-parkinsonian agents are phencyclidine agonists and N-methyl-aspartate antagonists.
Topics: Antiparkinson Agents; Aspartic Acid; Binding, Competitive; In Vitro Techniques; N-Methylaspartate; Phencyclidine; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1987 |
Phencyclidine (PCP)-like inhibition of N-methyl-D-aspartate-evoked striatal acetylcholine release, H-TCP binding and synaptosomal dopamine uptake by metaphit, a proposed PCP receptor acylator.
Topics: Acetylcholine; Acylation; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptosomes; Tritium; Tritolyl Phosphates | 1987 |
Functional reconstitution of N-methyl-D-aspartate receptors in artificial lipid bilayers.
Topics: Aspartic Acid; Kinetics; Lipid Bilayers; Membrane Potentials; N-Methylaspartate; Phosphatidylcholines; Phosphatidylethanolamines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Raised extracellular potassium relieves the blockade by magnesium of NMDA-induced cerebellar cyclic GMP production.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Extracellular Space; Magnesium; Magnesium Sulfate; N-Methylaspartate; Osmolar Concentration; Potassium; Potassium Chloride; Rats | 1987 |
Long-term development of selective neuronal loss and the mechanism of protection by 2-amino-7-phosphonoheptanoate in a rat model of incomplete forebrain ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cell Survival; Cerebrovascular Circulation; Hippocampus; Ischemic Attack, Transient; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Time Factors | 1988 |
A comparison of PCP-like compounds for NMDA antagonism in two in vivo models.
Topics: Animals; Aspartic Acid; Behavior, Animal; Dioxolanes; Dioxoles; Ketamine; Male; Mice; Motor Activity; N-Methylaspartate; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1988 |
Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.
Topics: Acetylcholine; Animals; Aspartic Acid; Brain; Male; N-Methylaspartate; Norepinephrine; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1986 |
NMDA-receptors on Purkinje cell dendrites in guinea pig cerebellar slices.
Topics: Animals; Aspartic Acid; Dendrites; Guinea Pigs; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminophylline; Animals; Anticonvulsants; Aspartic Acid; Diazepam; Female; Mice; N-Methylaspartate; Phenobarbital; Seizures; Synaptic Transmission; Valproic Acid | 1987 |
Differences in results from in vivo and in vitro studies on the use-dependency of N-methylaspartate antagonism by MK-801 and other phencyclidine receptor ligands.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Ketamine; N-Methylaspartate; Phencyclidine; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine; Spinal Cord; Substance-Related Disorders | 1988 |
Learning and memory: regional changes in N-methyl-D-aspartate receptors in the chick brain after imprinting.
Topics: Animals; Aspartic Acid; Chickens; Female; Functional Laterality; Glutamates; Imprinting, Psychological; Kinetics; Male; Memory; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Coexpression of N-methyl-D-aspartate and phencyclidine receptors in Xenopus oocytes injected with rat brain mRNA.
Topics: Animals; Aspartic Acid; Brain Chemistry; Dose-Response Relationship, Drug; Electrophysiology; Glycine; Microinjections; N-Methylaspartate; Oocytes; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; RNA, Messenger; Xenopus laevis | 1988 |
Kinetic characterization of the phencyclidine-N-methyl-D-aspartate receptor interaction: evidence for a steric blockade of the channel.
Topics: Animals; Aspartic Acid; Cell Membrane; Cerebral Cortex; Kinetics; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1988 |
Linkage between phencyclidine (PCP) and N-methyl-D-aspartate (NMDA) receptors in the cerebellum.
Topics: Animals; Aspartic Acid; Cerebellum; Cerebral Cortex; In Vitro Techniques; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1988 |
Cultured striatal neurons containing NADPH-diaphorase or acetylcholinesterase are selectively resistant to injury by NMDA receptor agonists.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Aspartic Acid; Cells, Cultured; Corpus Striatum; Embryo, Mammalian; Mice; N-Methylaspartate; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; Neurons; Pyridines; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
New quinoxalinediones show potent antagonism of quisqualate responses in cultured mouse cortical neurons.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Kainic Acid; Mice; N-Methylaspartate; Oxadiazoles; Quinoxalines; Quisqualic Acid; Receptors, AMPA; Receptors, Drug; Sodium | 1988 |
Blockade of N-methyl-D-aspartate response in enzyme-treated rat hippocampal neurons.
Topics: Animals; Aspartic Acid; Cell Separation; Hippocampus; Hydrolases; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Papain; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Trypsin | 1988 |
Stimulation of the N-methyl-D-aspartate receptor has a trophic effect on differentiating cerebellar granule cells.
Topics: Animals; Antigens, Surface; Aspartic Acid; Cell Adhesion Molecules; Cell Count; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellum; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetanus Toxin | 1988 |
N-methyl-D-aspartate (NMDA) receptors control respiratory off-switch in cat.
Topics: Action Potentials; Animals; Aspartic Acid; Cats; Dibenzocycloheptenes; Dizocilpine Maleate; Iontophoresis; Ketamine; N-Methylaspartate; Oxadiazoles; Phencyclidine; Phrenic Nerve; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Respiration; Respiratory Center | 1988 |
Disclosure by triton X-100 of NMDA-sensitive [3H] glutamate binding sites in brain synaptic membranes.
Topics: Amino Acids; Aspartic Acid; Binding, Competitive; Brain; Glutamates; In Vitro Techniques; Kinetics; Methods; N-Methylaspartate; Octoxynol; Polyethylene Glycols; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptic Membranes; Temperature | 1988 |
Phencyclidine receptor ligands attenuate cortical neuronal injury after N-methyl-D-aspartate exposure or hypoxia.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; L-Lactate Dehydrogenase; Ligands; Mice; N-Methylaspartate; Neurons; Oxygen; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1988 |
MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.
Topics: Anesthesia; Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Catalepsy; Columbidae; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Ketamine; Macaca mulatta; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Self Administration; Synaptic Transmission | 1988 |
Receptor specific inhibition of N-methyl-D-aspartate stimulated 22Na flux from rat hippocampal slices by phencyclidine and other drugs.
Topics: Animals; Aspartic Acid; Behavior, Animal; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Sodium Radioisotopes | 1988 |
Similarity and mutual exclusion of NMDA- and proton-activated transient Na+-currents in rat tectal neurons.
Topics: Animals; Aspartic Acid; N-Methylaspartate; Neurons; Protons; Rats; Sodium; Superior Colliculi | 1988 |
NMDA application potentiates synaptic transmission in the hippocampus.
Topics: Animals; Aspartic Acid; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neuronal Plasticity; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission; Time Factors | 1988 |
DL-2-amino-5-phosphonopentanoic acid, a specific N-methyl-D-aspartic acid receptor antagonist, suppresses pulsatile LH release in the rat.
Topics: Animals; Aspartic Acid; Luteinizing Hormone; Male; N-Methylaspartate; Orchiectomy; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
A potential role for excitotoxins in the pathophysiology of spinal cord injury.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord Injuries; Stereoisomerism; Toxins, Biological | 1988 |
Noradrenaline antagonizes and ouabain potentiates the effects of N-methyl-D-aspartate on rat cerebellar cyclic GMP production.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic AMP; Dioxanes; Dose-Response Relationship, Drug; Drug Synergism; Idazoxan; N-Methylaspartate; Norepinephrine; Osmolar Concentration; Ouabain; Rats; Rats, Inbred Strains | 1988 |
The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro.
Topics: Animals; Aspartic Acid; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Interactions; Electrophysiology; Kainic Acid; N-Methylaspartate; Osmolar Concentration; Phencyclidine; Receptors, Amino Acid; Receptors, Cell Surface | 1988 |
7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Electric Conductivity; Glycine; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Cycloleucine competitively antagonizes the strychnine-insensitive glycine receptor.
Topics: Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Cycloleucine; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Phencyclidine; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Strychnine | 1988 |
N-methyl-D-aspartate receptor regulation of uncompetitive antagonist binding in rat brain membranes: kinetic analysis.
Topics: Animals; Aspartic Acid; Brain; Glycine; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Activation of N-methyl-D-aspartate-sensitive glutamate receptors stimulates arachidonic acid release in primary cultures of cerebellar granule cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspartic Acid; Cells, Cultured; Cerebellum; Glutamates; N-Methylaspartate; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1988 |
Differences in magnesium and calcium effects on N-methyl-D-aspartate- and quisqualate-induced decreases in extracellular sodium concentration in rat hippocampal slices.
Topics: Action Potentials; Animals; Aspartic Acid; Calcium; Electric Stimulation; Hippocampus; In Vitro Techniques; Magnesium; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium | 1988 |
N-methyl-D-aspartate raises cytosolic calcium concentration in rat cerebellar granule cells in culture.
Topics: Animals; Aspartic Acid; Benzofurans; Calcium; Cells, Cultured; Cerebellum; Cytosol; Fluorescent Dyes; Fura-2; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Paradoxical convulsant action of a novel non-competitive N-methyl-D-aspartate (NMDA) antagonist, tiletamine.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cyclohexanes; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex, Monosynaptic; Seizures; Tiletamine | 1988 |
Kynurenic acid antagonises responses to NMDA via an action at the strychnine-insensitive glycine receptor.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Serine; Strychnine | 1988 |
CGS 19755 is a potent and competitive antagonist at NMDA-type receptors.
Topics: Acetylcholine; Animals; Aspartic Acid; Binding, Competitive; Blood-Brain Barrier; Cerebellum; Cyclic GMP; Harmaline; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1988 |
Stereoselective antagonism of NMDA-stimulated noradrenaline release from rat hippocampal slices by MK-801.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; Isomerism; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Trans-2-carboxy-3-pyrrolidineacetic acid (CPAA), a novel agonist at NMDA-type receptors.
Topics: Acetylcholine; Animals; Aspartic Acid; Corpus Striatum; In Vitro Techniques; Male; N-Methylaspartate; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tachyphylaxis | 1988 |
Isolated hippocampal neurons in cryopreserved long-term cultures: development of neuroarchitecture and sensitivity to NMDA.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cryoprotective Agents; Culture Techniques; Dendrites; Dimethyl Sulfoxide; Freezing; Hippocampus; N-Methylaspartate; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Time Factors | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cats; Female; Male; Models, Cardiovascular; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Vasoconstriction | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cells, Cultured; Cerebellum; Corpus Striatum; Cyclic GMP; Dopamine; Harmaline; In Vitro Techniques; Mice; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Comparison of the actions of phencyclidine and sigma ligands on CA1 hippocampal pyramidal neurons in the rat.
Topics: Action Potentials; Animals; Aspartic Acid; Guanidines; Hippocampus; Male; N-Methylaspartate; Neurons; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1988 |
Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes.
Topics: Animals; Aspartic Acid; Brain; Glutamates; Glycine; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Serine; Synaptic Membranes | 1988 |
Characterization of the binding of [3H]-CGS 19755: a novel N-methyl-D-aspartate antagonist with nanomolar affinity in rat brain.
Topics: Animals; Aspartic Acid; Brain; Intracellular Membranes; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Release of [3H]norepinephrine from rat hippocampal slices by N-methyl-D-aspartate: comparison of the inhibitory effects of Mg2+ and MK-801.
Topics: Amino Acids; Animals; Aspartic Acid; Convulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1988 |
NMDA receptor channels: labeling of MK-801 with iodine-125 and fluorine-18.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Chemical Phenomena; Chemistry; Dibenzocycloheptenes; Dizocilpine Maleate; Fluorine Radioisotopes; Iodine Radioisotopes; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cortical Spreading Depression; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Ketamine; Male; N-Methylaspartate; Phencyclidine; Phenytoin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Differential expression of glutamate receptors in Xenopus oocytes injected with messenger RNA from lobster muscle.
Topics: Animals; Aspartic Acid; Gene Expression Regulation; Membrane Potentials; Muscles; N-Methylaspartate; Nephropidae; Oocytes; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1988 |
Excitatory amino acids: role in morphine excitation in rat periaqueductal gray.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Kainic Acid; Male; Morphine; Motor Activity; N-Methylaspartate; Oxadiazoles; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
The NMDA receptor: central role in pain inhibition in rat periaqueductal gray.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Analgesia; Animals; Aspartic Acid; Kainic Acid; Male; Morphine; N-Methylaspartate; Oxadiazoles; Pain; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
The involvement of excitatory amino acid receptors within the prepiriform cortex in pilocarpine-induced limbic seizures in rats.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Kainic Acid; Male; N-Methylaspartate; Olfactory Bulb; Oxadiazoles; Pilocarpine; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Seizures | 1988 |
Sodium dependence of NMDA's effects on cyclic GMP production in immature rat cerebellar slices.
Topics: Animals; Aspartic Acid; Calcium Channels; Cerebellum; Cyclic GMP; N-Methylaspartate; Rats; Sodium | 1988 |
The NMDA antagonists, CPP and CGS 19755, lack affinity for central benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; Brain; Flunitrazepam; In Vitro Techniques; N-Methylaspartate; Pipecolic Acids; Piperazines; Piperidines; Rats; Receptors, GABA-A | 1988 |
Phencyclidine receptors and N-methyl-D-aspartate antagonism: electrophysiologic data correlates with known behaviours.
Topics: Anesthetics, Dissociative; Animals; Anura; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Electrophysiology; Ketamine; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Spinal Cord | 1988 |
Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo.
Topics: Animals; Aspartic Acid; Brain; Calpain; Cytosol; Enzyme Activation; Erythrocytes; Humans; Isoenzymes; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Peptide Mapping; Rats; Rats, Inbred Strains; Spectrin; Substrate Specificity | 1988 |
Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Corpus Callosum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Ketamine; Male; Muscimol; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Tetrodotoxin | 1985 |
Roles of aspartate and glutamate in synaptic transmission in rabbit retina. I. Outer plexiform layer.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Neurotransmitter Agents; Rabbits; Retina; Synaptic Transmission | 1985 |
Muscle relaxant action of excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Female; Glutamates; Kynurenic Acid; Male; Muscle Relaxants, Central; Muscle Spasticity; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1985 |
Effects of anti-glutamate-binding protein antibodies on synaptic membrane ion flux, glutamate transport and release, and L-glutamate binding activities.
Topics: Animals; Antibodies; Aspartic Acid; Biological Transport; Cattle; Glutamates; Glutamic Acid; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium; Synaptic Membranes; Thiocyanates | 1985 |
Excitotoxin lesions suggest an aspartatergic projection from rat medial prefrontal cortex to ventral tegmental area.
Topics: Animals; Aspartic Acid; Efferent Pathways; Frontal Lobe; Glutamates; Glutamic Acid; N-Methylaspartate; Rats; Synaptic Transmission; Tegmentum Mesencephali | 1985 |
Excitatory effects of L-glutamate and some analogs on isolated horizontal cells from the catfish retina.
Topics: Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Retina | 1985 |
Anticonvulsant action of beta-kainic acid in mice. Is beta-kainic acid an N-methyl-D-aspartate antagonist?
Topics: Animals; Anticonvulsants; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Homocysteine; Kainic Acid; Mice; N-Methylaspartate; Oxadiazoles; Pyrrolidines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Seizures; Stereoisomerism | 1985 |
Effects of excitatory amino acids on calcium transport by brain membranes.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Brain Chemistry; Calcium; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Neurotransmitter Agents; Synaptosomes | 1985 |
Calcium influx accompanies but does not cause excitotoxin-induced neuronal necrosis in retina.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Aspartic Acid; Calcium; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Mice; N-Methylaspartate; Necrosis; Nicotinic Acids; Nimodipine; Pyrrolidines; Retina | 1985 |
Anticonvulsant properties of 3-hydroxy-2-quinoxalinecarboxylic acid, a newly found antagonist of excitatory amino acids.
Topics: Animals; Anticonvulsants; Aspartic Acid; Electroencephalography; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Picrotoxin; Pyrrolidines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Structure-Activity Relationship | 1985 |
Pharmacological characterization of postsynaptic receptors for excitatory amino acids in Purkinje cell dendrites in the guinea pig cerebellum.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dendrites; Dipeptides; Drug Synergism; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Purkinje Cells; Receptors, Neurotransmitter | 1985 |
Synaptic transmission between dorsal root ganglion and dorsal horn neurons in culture: antagonism of monosynaptic excitatory postsynaptic potentials and glutamate excitation by kynurenate.
Topics: Animals; Aspartic Acid; Cells, Cultured; Evoked Potentials; Female; Ganglia, Spinal; Glutamates; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Pregnancy; Rats; Spinal Cord; Synaptic Transmission | 1985 |
Excitatory aminoacid antagonists provide a therapeutic approach to neurological disorders.
Topics: Adult; Amino Acids; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Glutamates; Humans; Hypoxia, Brain; Infant; N-Methylaspartate; Nerve Degeneration; Neurotransmitter Agents; Quinolinic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1985 |
L-[3H]Glutamate binds to kainate-, NMDA- and AMPA-sensitive binding sites: an autoradiographic analysis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Chemistry; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1985 |
Mg2+ reduces N-methyl-D-aspartate neurotoxicity in embryonic chick neural retina in vitro.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Animals; Aspartic Acid; Chick Embryo; In Vitro Techniques; Magnesium; N-Methylaspartate; Retina; Valine | 1985 |
Effects of bath-applied excitatory amino acids and their analogs on spinal interneurons of the lamprey.
Topics: Amino Acids; Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; Glycine; Homocysteine; In Vitro Techniques; Interneurons; Kainic Acid; Lampreys; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Spinal Cord | 1985 |
Antagonism of N-methyl-D-aspartate-induced transmitter release in the rat striatum by phencyclidine-like drugs and its relationship to turning behavior.
Topics: Acetylcholine; Amphetamine; Animals; Apomorphine; Aspartic Acid; Benzomorphans; Chlorpromazine; Clozapine; Corpus Striatum; Cyclazocine; Dioxolanes; Dopamine; Haloperidol; Ketamine; Male; Mathematics; Motor Activity; N-Methylaspartate; Phencyclidine; Posture; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
L-Homocysteic acid as an alternative cytotoxin for studying glutamate-induced cellular degeneration of Huntington's disease and normal skin fibroblasts.
Topics: Aspartic Acid; Cell Survival; Cells, Cultured; Cysteic Acid; Cysteine; Fibroblasts; Glutamates; Glutamic Acid; Homocysteine; Humans; Huntington Disease; In Vitro Techniques; Isomerism; Kainic Acid; Kinetics; N-Methylaspartate; Neurotransmitter Agents; Skin; Time Factors | 1985 |
Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Glutamates; Glutamic Acid; Kinetics; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tissue Distribution | 1985 |
Effect of excitatory amino acids and analogues on [3H]acetylcholine release from amacrine cells of the rabbit retina.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cholinergic Fibers; Electroretinography; N-Methylaspartate; Neurons; Pipecolic Acids; Rabbits; Receptors, Amino Acid; Receptors, Cell Surface; Retina; Valine | 1985 |
Synaptic transmission at N-methyl-D-aspartate receptors in the proximal retina of the mudpuppy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; In Vitro Techniques; N-Methylaspartate; Necturus; Receptors, Amino Acid; Receptors, Cell Surface; Retina; Retinal Ganglion Cells; Synapses; Synaptic Transmission; Valine | 1985 |
Peptides derived from kainic acid as antagonists of N-methyl-D-aspartate-induced neuroexcitation in rat brain.
Topics: Animals; Aspartic Acid; Corpus Striatum; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats | 1985 |
Excitatory and inhibitory responses of Purkinje cells, in the rat cerebellum in vivo, induced by excitatory amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Neurochemical relation between excitatory and inhibitory amino acids in hippocampus.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Cysteine; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons; Neurotransmitter Agents; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains | 1985 |
Calcium and unit response decrement to locally applied glutamate on rat hippocampal CA1 neurons.
Topics: Animals; Aspartic Acid; Calcium; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Iontophoresis; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains | 1985 |
A dipeptide derived from kainic and L-glutamic acids: a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties.
Topics: Animals; Aspartic Acid; Cell Membrane Permeability; Corpus Striatum; Dipeptides; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Oxadiazoles; Picrotoxin; Quisqualic Acid; Rats; Seizures; Sodium | 1985 |
Ketamine acts as a non-competitive N-methyl-D-aspartate antagonist on frog spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Kainic Acid; Ketamine; Magnesium; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana pipiens; Rana temporaria; Spinal Cord; Valine | 1985 |
The role of putative excitatory amino acid neurotransmitters in the initiation of locomotion in the lamprey spinal cord. II. The effects of amino acid uptake inhibitors.
Topics: Amino Acids; Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Lampreys; Locomotion; N-Methylaspartate; Neurotransmitter Agents; Spinal Cord; Synaptic Transmission | 1985 |
Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1986 |
Action of excitatory amino acids and their antagonists on hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Guinea Pigs; Hippocampus; Iontophoresis; Manganese; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Tetrodotoxin; Valine | 1985 |
Evidence for an excitatory amino acid as the transmitter of the auditory nerve in the in vitro mouse cochlear nucleus.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cochlear Nerve; Dose-Response Relationship, Drug; Evoked Potentials; Female; Kainic Acid; Male; Mice; Mice, Inbred C3H; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Receptors, Neurotransmitter; Valine; Vestibulocochlear Nerve | 1985 |
Excitatory amino acid analogs evoke release of endogenous amino acids and acetyl choline from chick retina in vitro.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Calcium; Chickens; Dose-Response Relationship, Drug; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Potassium; Quisqualic Acid; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Sodium; Stimulation, Chemical | 1985 |
Induction of glutamate binding sites in hippocampal membranes by transient exposure to high concentrations of glutamate or glutamate analogs.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Aminobutyrates; Animals; Aspartic Acid; Binding Sites; Chlorides; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Saponins; Sodium; Valine | 1986 |
A comparison of the effects of quinolinate and N-methyl-aspartate on neurons in rat piriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Iontophoresis; N-Methylaspartate; Neurons; Pyridines; Quinolinic Acids; Rats; Valine | 1986 |
An excitatory amino acid projection from rat prefrontal cortex to periaqueductal gray.
Topics: Animals; Aspartic Acid; Frontal Lobe; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Necrosis; Neurotransmitter Agents; Periaqueductal Gray; Rats; Rats, Inbred Strains; Synaptosomes | 1986 |
A magnesium-sensitive post-synaptic potential in rat cerebral cortex resembles neuronal responses to N-methylaspartate.
Topics: Action Potentials; Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Neurons; Rats; Sensory Thresholds; Synapses | 1986 |
Comparison of responses to transmitter candidates at an N-methylaspartate receptor mediated synapse, in slices of rat cerebral cortex.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Cysteic Acid; Cysteine; Glutamates; Glutamic Acid; Magnesium; Male; N-Methylaspartate; Neurotransmitter Agents; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission | 1986 |
Ca2+-dependent depolarization and burst firing of rat CA1 pyramidal neurones induced by N-methyl-D-aspartic acid and quinolinic acid: antagonism by 2-amino-5-phosphonovaleric and kynurenic acids.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Calcium; Convulsants; Electric Conductivity; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Valine | 1986 |
(+/-)-cis-2,3-Piperidine dicarboxylic acid is a partial N-methyl-D-aspartate agonist in the in vitro rat cerebellar cGMP model.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Inbred Strains; Valine | 1986 |
Quantitative studies of N-methyl-D-aspartate, 2-amino-5-phosphonovalerate and cis-2,3-piperidine dicarboxylate interactions on the neonatal rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electrophysiology; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Inbred Strains; Spinal Cord; Valine | 1986 |
Effects of topically applied excitatory amino acids on evoked potentials and single cell activity in rat cerebral cortex.
Topics: Administration, Topical; Amino Acids; Animals; Aspartic Acid; Carbachol; Cerebral Cortex; Evoked Potentials, Somatosensory; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tetrodotoxin | 1986 |
Activity of beta-kainic acid on neocortical neurons in vivo and hippocampal neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dipeptides; Dose-Response Relationship, Drug; Evoked Potentials, Somatosensory; Hippocampus; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Receptors, Neurotransmitter; Valine | 1986 |
2-Amino-5-phosphonovalerate and Co2+ selectively block depolarization and burst firing of rat hippocampal CA1 pyramidal neurones by N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Cobalt; Evoked Potentials; Hippocampus; Iontophoresis; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Quisqualic Acid; Rats; Tetrodotoxin; Valine | 1986 |
N-methyl D-aspartate acts as an antagonist of the photoreceptor transmitter in the carp retina.
Topics: Animals; Aspartic Acid; Carps; Glutamates; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neural Inhibition; Neurotransmitter Agents; Photic Stimulation; Photoreceptor Cells; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1986 |
The rat ventromedial thalamic nucleus and motor control: role of N-methyl-D-aspartate-mediated excitation, GABAergic inhibition, and muscarinic transmission.
Topics: Animals; Aspartic Acid; Electromyography; gamma-Aminobutyric Acid; Locomotion; Male; Movement; Muscimol; Muscle Contraction; N-Methylaspartate; Neuromuscular Junction; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Synaptic Transmission; Thalamic Nuclei | 1986 |
Pharmacologically distinct glutamate receptors on cerebellar granule cells.
Topics: 2-Aminoadipic Acid; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1986 |
Absence of side-effects in the anticonvulsant action of cortically applied antagonists of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dipeptides; Morphine; N-Methylaspartate; Picrotoxin; Quinoxalines; Rats; Rats, Inbred Strains; Seizures; Strychnine; Valine | 1986 |
A comparative study on the elicitability of vocalization by electrical brain stimulation, glutamate, aspartate and quisqualate in the squirrel monkey.
Topics: Animals; Aspartic Acid; Brain Mapping; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Reaction Time; Saimiri; Vocalization, Animal | 1986 |
The presence of N-methyl-D-aspartate-type receptors for glutamic acid in the guinea pig myenteric plexus.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscles; Myenteric Plexus; N-Methylaspartate; Receptors, Glutamate; Receptors, Neurotransmitter | 1986 |
Role of excitatory amino acid transmission in the genesis of seizures elicited from the deep prepiriform cortex.
Topics: Animals; Aspartic Acid; Bicuculline; Carbachol; Glutamates; Glutamic Acid; Kainic Acid; Limbic System; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1986 |
Receptors for excitatory amino acids on neurons in rat pyriform cortex.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Limbic System; N-Methylaspartate; Olfactory Pathways; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Neurotransmitter; Synaptic Transmission | 1986 |
Chemoresponsiveness of intracellular nuclei neurones to L-aspartate, L-glutamate and related derivatives in rat cerebellar slices maintained in vitro.
Topics: Animals; Aspartic Acid; Cerebellar Nuclei; Convulsants; Glutamates; Glutamic Acid; In Vitro Techniques; Injections; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Comparative actions of quisqualate and N-methyl-D-aspartate, excitatory amino acid agonists, on guinea-pig cochlear potentials.
Topics: Action Potentials; Animals; Aspartic Acid; Cochlea; Dose-Response Relationship, Drug; Evoked Potentials; Glutamates; Glutamic Acid; Guinea Pigs; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Vestibulocochlear Nerve | 1986 |
Respiratory motoneuronal activity is altered by injections of picomoles of glutamate into cat brain stem.
Topics: Animals; Aspartic Acid; Blood Pressure; Brain Stem; Cats; Dose-Response Relationship, Drug; Electrophysiology; Glutamates; Glutamic Acid; Homocysteine; Microchemistry; Motor Neurons; N-Methylaspartate; Respiration | 1986 |
Characterization of the inhibition of excitatory amino acid-induced neurotransmitter release in the rat striatum by phencyclidine-like drugs.
Topics: Animals; Aspartic Acid; Corpus Striatum; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Neurotransmitter Agents; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1986 |
Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Behavior, Animal; Catalepsy; Columbidae; Dose-Response Relationship, Drug; Injections, Intraventricular; N-Methylaspartate; Phencyclidine; Stereotyped Behavior; Valine | 1986 |
Neurons containing NADPH-diaphorase are selectively resistant to quinolinate toxicity.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Humans; Huntington Disease; Kainic Acid; Mice; N-Methylaspartate; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; Neurons; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid | 1986 |
The relative potencies of (-)-2-amino-5-phosphonovalerate and (-)-2-amino-7-phosphonoheptanoate as antagonists of N-methylaspartate and quinolinic acids and repetitive spikes in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Valine | 1986 |
CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Binding Sites; Brain; Cats; Cell Membrane; Interneurons; Membrane Potentials; Mice; Motor Neurons; N-Methylaspartate; Neurons; Piperazines; Rats; Spinal Cord; Valine | 1986 |
Action of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP): a new and highly potent antagonist of N-methyl-D-aspartate receptors in the hippocampus.
Topics: Animals; Aspartic Acid; Cell Membrane; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; N-Methylaspartate; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1986 |
Localization of [3H]glutamate binding sites in rat adrenal medulla.
Topics: Acetates; Acetic Acid; Adrenal Medulla; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cerebral Cortex; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Organ Specificity; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1986 |
Continuously infused 2-amino-7-phosphonoheptanoic acid antagonizes N-methyl-D-aspartate-induced elevations of cyclic GMP in vivo in multiple brain areas and chemically-induced seizure activity.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Barbiturates; Bicuculline; Brain; Brain Chemistry; Cyclic GMP; Female; Injections, Intraventricular; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Inbred Strains | 1986 |
Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Autoradiography; Female; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Male; Middle Aged; N-Methylaspartate; Neuronal Plasticity; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission | 1986 |
Deep prepyriform cortex kindling and its relation to amygdala kindling in the rat.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amygdala; Animals; Aspartic Acid; Cerebral Cortex; Electroencephalography; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Muscimol; N-Methylaspartate; Rats; Valine | 1986 |
Stimulatory effect of N-methyl aspartate on locomotor activity and transmitter release from rat nucleus accumbens.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Aspartic Acid; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Motor Activity; N-Methylaspartate; Nialamide; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Valine | 1986 |
Excitatory amino acids and regenerative activity in cultured neurons.
Topics: Animals; Aspartic Acid; Cells, Cultured; Electric Conductivity; Ketamine; Membrane Potentials; N-Methylaspartate; Neurons; Neurotransmitter Agents; Phencyclidine; Spinal Cord | 1986 |
Blockade by D-aminophosphonovalerate or Mg2+ of excitatory amino acid-induced responses on spinal motoneurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Electric Conductivity; Excitatory Amino Acid Antagonists; In Vitro Techniques; Magnesium; Membrane Potentials; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana temporaria; Synaptic Transmission; Valine | 1986 |
Cellular origins of cyclic GMP responses to excitatory amino acid receptor agonists in rat cerebellum in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Drug Interactions; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Nitroprusside; Purkinje Cells; Rats; Tetrodotoxin | 1987 |
Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding.
Topics: Alzheimer Disease; Aspartic Acid; Autoradiography; Flunitrazepam; Glutamates; Glutamic Acid; Hippocampus; Histocytochemistry; Humans; Muscimol; N-Methylaspartate; Receptors, GABA-A; Receptors, Muscarinic; Tissue Distribution | 1987 |
Magnesium ions inhibit the stimulation of inositol phospholipid hydrolysis by endogenous excitatory amino acids in primary cultures of cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Drug Synergism; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; Kainic Acid; Magnesium; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Sugar Phosphates; Valine; Veratridine | 1987 |
Phencyclidine selectively inhibits N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Structure-Activity Relationship; Valine | 1987 |
Excitatory amino acids and intracellular pH in motoneurons of the isolated frog spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anterior Horn Cells; Anura; Aspartic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Kainic Acid; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Valine | 1986 |
Solubilization of novel binding sites for [3H]glutamate in rat adrenal.
Topics: Adrenal Glands; Animals; Aspartic Acid; Detergents; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Solubility | 1987 |
Excitatory amino acid receptors and ischemic brain damage in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Hippocampus; Ibotenic Acid; Ischemic Attack, Transient; Kainic Acid; N-Methylaspartate; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Neurotransmitter; Time Factors | 1987 |
Aortic baroreceptor reflexes are mediated by NMDA receptors in caudal ventrolateral medulla.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aorta; Aspartic Acid; Electric Stimulation; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Injections, Intraventricular; Medulla Oblongata; Microinjections; N-Methylaspartate; Pressoreceptors; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex; Synaptic Transmission; Valine | 1987 |
Comparison of L-[3H]glutamate, D-[3H]aspartate, DL-[3H]AP5 and [3H]NMDA as ligands for NMDA receptors in crude postsynaptic densities from rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Brain; Brain Chemistry; Chemical Phenomena; Chemistry; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1987 |
The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Electric Stimulation; Electrophysiology; Epilepsy; Hippocampus; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1987 |
CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.
Topics: Acetylcholine; Animals; Aspartic Acid; Cerebellum; Corpus Striatum; Cyclic GMP; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1987 |
Enhancement of [3H]glutamate binding by N-methyl-D-aspartic acid in rat adrenal.
Topics: Adrenal Glands; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Male; Membranes; Molecular Conformation; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium; Stimulation, Chemical | 1987 |
Identification and characterization of an N-methyl-D-aspartate-specific L-[3H]glutamate recognition site in synaptic plasma membranes.
Topics: Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Ions; Kinetics; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptic Membranes; Temperature; Time Factors | 1987 |
Postsynaptic control of hippocampal long-term potentiation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Evoked Potentials; GABA Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; N-Methylaspartate; Picrotoxin; Synapses; Valine | 1986 |
Biphasic effect of quinolinate on frog spinal, but not rat cortical, neurones: N-methyl-D-aspartate-like depolarisation and a novel type of hyperpolarisation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anterior Horn Cells; Anura; Aspartic Acid; Drug Interactions; Gyrus Cinguli; Kainic Acid; Ketamine; Magnesium; Membrane Potentials; Motor Neurons; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Valine | 1987 |
Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Membrane; Cerebral Cortex; Drug Interactions; Electrophysiology; Homocysteine; Ibotenic Acid; Kainic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Oxadiazoles; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Zinc | 1987 |
Cytoplasmic calcium elevation in hippocampal granule cell induced by perforant path stimulation and L-glutamate application.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Anticonvulsants; Aspartic Acid; Benzofurans; Calcium; Cytoplasm; Egtazic Acid; Electric Stimulation; Fluorescent Dyes; Fura-2; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neural Pathways; Tetrodotoxin; Valine | 1987 |
The effects of prolonged superfusions with acidic amino acids and their agonists on field potentials and horizontal cell photoresponses in the turtle retina.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Perfusion; Photoreceptor Cells; Retina; Turtles | 1987 |
Bursting in human epileptogenic neocortex is depressed by an N-methyl-D-aspartate antagonist.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anticonvulsants; Aspartic Acid; Epilepsy, Temporal Lobe; Humans; In Vitro Techniques; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Temporal Lobe; Valine | 1987 |
N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Aspartic Acid; Evoked Potentials, Visual; N-Methylaspartate; Rana pipiens; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Superior Colliculi; Valine | 1987 |
The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes; Valine | 1987 |
Evidence for a direct action of N-methylaspartate on non-neuronal cells.
Topics: Amino Acids; Animals; Aspartic Acid; Cell Survival; Dialysis; Ethanolamines; Extracellular Space; Glutamates; Glutamic Acid; Glutamine; Hippocampus; Male; N-Methylaspartate; Neuroglia; Purines; Rats; Rats, Inbred Strains; Taurine | 1987 |
Respiratory and vasomotor effects of excitatory amino acid on ventral medullary surface.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apnea; Aspartic Acid; Blood Pressure; Carotid Sinus; Cats; Female; Glutamates; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Oxadiazoles; Phrenic Nerve; Quisqualic Acid; Respiration; Vagotomy; Valine; Vasomotor System | 1987 |
An endogenous ligand of the brain sigma/PCP receptor antagonizes NMDA-induced neurotransmitter release.
Topics: Acetylcholine; Animals; Aspartic Acid; Cattle; Corpus Striatum; Dopamine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurotransmitter Agents; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Tissue Extracts | 1987 |
Postnatal development of the chemosensitivity of rat cerebellar Purkinje cells to excitatory amino acids. An in vitro study.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cerebellar Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Reaction Time; Valine | 1987 |
Excitatory amino acid receptor potency and subclass specificity of sulfur-containing amino acids.
Topics: Amino Acids, Sulfur; Aminobutyrates; Animals; Aspartic Acid; Brain; Chick Embryo; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Sodium; Synaptic Membranes | 1987 |
Excitatory amino acid-induced release of 3H-GABA from cultured mouse cerebral cortex interneurons.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Binding Sites; Cerebral Cortex; gamma-Aminobutyric Acid; Kainic Acid; Mice; N-Methylaspartate; Neurons; Oxadiazoles; Potassium; Quisqualic Acid; Valine | 1987 |
Effects of ketamine on the in vivo toxicity of quinolinate and N-methyl-D-aspartate in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Anesthesia, General; Animals; Aspartic Acid; Drug Interactions; Female; Halothane; Hippocampus; Ketamine; N-Methylaspartate; Pentobarbital; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Valine | 1987 |
Inhibition of N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release by phencyclidine is dependent on potassium concentration.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Hippocampus; In Vitro Techniques; Magnesium Sulfate; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Potassium; Rats; Rats, Inbred Strains; Valine | 1987 |
A role for the ventral surface of the medulla in regulation of nasal resistance.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Airway Resistance; Animals; Aspartic Acid; Blood Pressure; Cats; Lidocaine; Medulla Oblongata; N-Methylaspartate; Nose; Phrenic Nerve; Receptors, Amino Acid; Receptors, Neurotransmitter; Valine | 1987 |
Effects of ketamine and (+)cyclazocine on 4-aminopyridine and "magnesium free" epileptogenic activity in hippocampal slices of rats.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Aminopyridines; Animals; Aspartic Acid; Cyclazocine; Epilepsy; Hippocampus; Ketamine; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Synaptic Transmission; Valine | 1987 |
AMPA is a powerful neurotoxin in the chicken retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Chickens; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Ibotenic Acid; Injections; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Oxadiazoles; Oxazoles; Quisqualic Acid; Retina; Retinal Ganglion Cells; Vitreous Body | 1987 |
L-glutamate and N-methyl-D-asparatate actions on membrane potential and conductance of cat abducens motoneurones.
Topics: Abducens Nerve; Action Potentials; Animals; Aspartic Acid; Cats; Electric Conductivity; Glutamates; Glutamic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neural Conduction | 1987 |
[3H]norepinephrine release from hippocampal slices is an in vitro biochemical tool for investigating the pharmacological properties of excitatory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Tetrodotoxin | 1987 |
Dual action of excitatory amino acids on the metabolism of inositol phosphates in striatal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Carbachol; Cells, Cultured; Corpus Striatum; Glutamates; Inositol Phosphates; Mice; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Sugar Phosphates; Valine | 1987 |
Hippocampal cells primed with quisqualate are depolarized by AP4 and AP6, ligands for a putative glutamate uptake site.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Aminocaproates; Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Norleucine; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1987 |
Glutamate-induced ionic currents in cultured neurons from the rat superior colliculus.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Glutamates; Glutamic Acid; Magnesium; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Superior Colliculi | 1987 |
Intrathecal N-methyl-D-aspartate (NMDA) activates both nociceptive and antinociceptive systems.
Topics: 2-Amino-5-phosphonovalerate; Analgesia; Animals; Aspartic Acid; Behavior, Animal; Decerebrate State; Injections, Spinal; Male; N-Methylaspartate; Nociceptors; Pain; Rats; Valine | 1987 |
The mouse neocortical slice: preparation and responses to excitatory amino acids.
Topics: Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Bicuculline; Cerebral Cortex; Corpus Callosum; In Vitro Techniques; Kainic Acid; Male; Membrane Potentials; Mice; Mice, Inbred Strains; N-Methylaspartate; Ouabain; Oxadiazoles; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Tetrodotoxin | 1987 |
Amino acid influences on seizures elicited within the inferior colliculus.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Inferior Colliculi; Male; Muscimol; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Taurine | 1987 |
Autoradiographic localization of cerebellar excitatory amino acid binding sites in the mouse.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Cerebellum; Glutamates; Glutamic Acid; Kainic Acid; Mice; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface | 1987 |
Peripheral type benzodiazepine binding sites are a sensitive indirect index of neuronal damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding Sites; Choline O-Acetyltransferase; Corpus Striatum; Glutamate Decarboxylase; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
The effects of excitatory amino acids and their antagonists on the generation of motor activity in the isolated chick spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Chick Embryo; Convulsants; Dipeptides; In Vitro Techniques; Kynurenic Acid; Motor Activity; Motor Neurons; N-Methylaspartate; Spinal Cord; Valine | 1987 |
Lesions of putative glutamatergic pathways potentiate the increase of inositol phospholipid hydrolysis elicited by excitatory amino acids.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Colchicine; Corpus Striatum; Glutamates; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1987 |
L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor.
Topics: Animals; Aspartic Acid; Binding, Competitive; Brain; Chick Embryo; Glutamates; Glutamic Acid; Homocysteine; Kainic Acid; Ligands; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1987 |
L-homocysteic acid but not L-glutamate is an endogenous N-methyl-D-aspartic acid receptor preferring agonist in rat neocortical neurons in vitro.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Oxadiazoles; Quisqualic Acid; Valine | 1988 |
Differential effects of serotonin on the spontaneous discharge and on the excitatory amino acid-induced responses of deep cerebellar nuclei neurons in rat cerebellar slices.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Calcium; Cerebellar Nuclei; Drug Interactions; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Serotonin | 1987 |
Epileptiform activity induced by alkalosis in rat neocortical slices: block by antagonists of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Alkalosis; Animals; Aspartic Acid; Cerebral Cortex; Epilepsy; In Vitro Techniques; Ketamine; Magnesium Deficiency; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1987 |
The pharmacological selectivity of three NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hexamethonium Compounds; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Norepinephrine; Piperazines; Rats; Serotonin; Synaptic Transmission; Valine | 1988 |
Rapid desensitization of glutamate receptors in vertebrate central neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Electric Conductivity; Hippocampus; Ibotenic Acid; In Vitro Techniques; Iontophoresis; Kynurenic Acid; N-Methylaspartate; Oxadiazoles; Pressure; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Time Factors | 1988 |
Fictive locomotion in the lamprey; a comparison using bicarbonate and HEPES buffers.
Topics: Animals; Aspartic Acid; Bicarbonates; Buffers; Fishes; Glutamates; Glutamic Acid; HEPES; Lampreys; Locomotion; N-Methylaspartate; Spinal Cord | 1988 |
Excitatory amino acid-evoked membrane currents and excitatory synaptic transmission in lamprey reticulospinal neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Stem; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Lampreys; N-Methylaspartate; Neurons; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Spinal Cord; Synapses; Synaptic Transmission | 1988 |
A novel interaction between dynorphin(1-13) and an N-methyl-D-aspartate site.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Aspartic Acid; Atropine; Binding, Competitive; Dipeptides; Dynorphins; Hot Temperature; Kinetics; Male; N-Methylaspartate; Pain; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Utilization of the synthetic phosphagen cyclocreatine phosphate by a simple brain model during stimulation by neuroexcitatory amino acids.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Chick Embryo; Glutamates; Glutamic Acid; Homocysteine; Imidazolidines; Kainic Acid; Magnesium; N-Methylaspartate; Phosphocreatine | 1988 |
Enhancement of the oxygen consumption in the hippocampal slices of the guinea pig induced by glutamate and its related substances.
Topics: Action Potentials; Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxygen Consumption | 1988 |
A quantitative pharmacological analysis of some excitatory amino acid receptors in the mouse neocortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Ibotenic Acid; In Vitro Techniques; Kynurenic Acid; Male; Mice; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Valine | 1988 |
An excitatory amino acid projection from ventromedial hypothalamus to periaqueductal gray in the rat: autoradiographic and electrophysiological evidence.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Autoradiography; Electric Stimulation; Kainic Acid; Male; N-Methylaspartate; Neural Pathways; Periaqueductal Gray; Rats; Rats, Inbred Strains; Reaction Time; Valine; Ventromedial Hypothalamic Nucleus | 1988 |
Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize N-methyl-D-aspartate in brain slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Antitussive Agents; Aspartic Acid; Cerebral Cortex; Dextromethorphan; Dextrorphan; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Levorphanol; Morphinans; N-Methylaspartate; Seizures; Valine | 1988 |
The modulation of excitatory amino acid responses by serotonin in the cat neocortex in vitro.
Topics: Animals; Aspartic Acid; Cats; Cerebral Cortex; Cinanserin; Electric Stimulation; Evoked Potentials; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; Membrane Potentials; Methysergide; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Serotonin; Tetraethylammonium Compounds; Tetrodotoxin | 1987 |
Solubilization of rat brain phencyclidine receptors in an active binding form that is sensitive to N-methyl-D-aspartate receptor ligands.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Brain Chemistry; Cell Membrane; Cholic Acid; Cholic Acids; Detergents; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Solubility; Valine | 1988 |
Inhibition by forskolin of excitatory amino acid-induced accumulation of cyclic AMP in guinea pig hippocampal slices.
Topics: Adenosine; Amino Acids; Animals; Aspartic Acid; Chlorides; Colforsin; Cyclic AMP; Cysteine; Drug Interactions; Ethylmaleimide; Glutamates; Glutamic Acid; Guanosine Triphosphate; Guinea Pigs; Hippocampus; Histamine; Male; N-Methylaspartate; Neurotransmitter Agents; Veratridine | 1988 |
NMDA- and kainate-evoked GABA release from striatal neurones differentiated in primary culture: differential blocking by phencyclidine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Corpus Striatum; gamma-Aminobutyric Acid; Kainic Acid; Mice; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Rapid desensitization of glutamate receptors in vertebrate central neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Electric Conductivity; Hippocampus; Ibotenic Acid; In Vitro Techniques; Iontophoresis; Kynurenic Acid; N-Methylaspartate; Oxadiazoles; Pressure; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Time Factors | 1988 |
A new and specific non-NMDA receptor antagonist, FG 9065, blocks L-AP4-evoked depolarization in rat cerebral cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Animals; Aspartic Acid; Cerebral Cortex; Evoked Potentials; In Vitro Techniques; N-Methylaspartate; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1988 |
Quinolinic acid effects on amino acid release from the rat cerebral cortex in vitro and in vivo.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Valine | 1988 |
Differential control by N-methyl-D-aspartate and kainate of striatal dopamine release in vivo: a trans-striatal dialysis study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Atropine; Carbachol; Corpus Striatum; Dopamine; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Tetrodotoxin; Valine | 1988 |
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
Topics: Acetylcholine; Aconitine; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Binding, Competitive; Darkness; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Structure-Activity Relationship; Tetrodotoxin | 1988 |
L-glutamate-induced depolarization in solitary photoreceptors: a process that may contribute to the interaction between photoreceptors in situ.
Topics: Animals; Aspartic Acid; Axons; Dose-Response Relationship, Drug; Electric Conductivity; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Photoreceptor Cells; Quisqualic Acid; Sodium; Turtles | 1988 |
Amino acids modulate calcium permeability of the plasma membrane of human neuroblastoma cells.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aspartic Acid; Calcium; Cell Membrane Permeability; Cysteine; Humans; Kainic Acid; N-Methylaspartate; Neuroblastoma; Neurotransmitter Agents; Tumor Cells, Cultured; Valine | 1988 |
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding, Competitive; Cell Membrane; Cerebral Cortex; Ibotenic Acid; Kainic Acid; Ketamine; N-Methylaspartate; Neurons; Piperazines; Quinoxalines; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Effects of excitatory amino acids on the oxygen consumption of hippocampal slices from the guinea pig.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Glutamates; Guinea Pigs; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxadiazoles; Oxygen Consumption; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Spider Venoms; Valine | 1988 |
Influence of dynorphin (1-13) on spinal reflexes in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dynorphins; Electrophysiology; Injections, Spinal; Male; N-Methylaspartate; Nerve Fibers; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Spinal Cord; Valine | 1988 |
Quantitative correlation between tetanus-induced decreases in extracellular calcium and LTP.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Calcium; Electric Stimulation; Extracellular Space; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Differential effects of N-methyl-D-aspartic acid and L-homocysteic acid on cerebellar Purkinje neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Dipeptides; Glutamates; Homocysteine; Iontophoresis; Ketamine; Male; N-Methylaspartate; Purkinje Cells; Rats; Rats, Inbred Strains; Valine | 1988 |
Maturational changes in retinal excitatory amino acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding, Competitive; Chick Embryo; Embryonic and Fetal Development; Glutamates; Glutamic Acid; Ibotenic Acid; Kinetics; N-Methylaspartate; Receptors, Amino Acid; Receptors, Cell Surface; Retina | 1988 |
Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801.
Topics: Animals; Anticonvulsants; Aspartic Acid; Calcium; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; N-Methylaspartate; Rats; Retina; Retinal Ganglion Cells | 1988 |
Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phosphonovalerate (D-AP5) on rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Evoked Potentials; Glycine; In Vitro Techniques; N-Methylaspartate; Pyrrolidinones; Rats; Valine | 1988 |
Focal cerebral ischaemia in the cat: treatment with the glutamate antagonist MK-801 after induction of ischaemia.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain Ischemia; Cats; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate | 1988 |
Phorbol esters attenuate glutamate-stimulated inositol phospholipid hydrolysis in neuronal cultures.
Topics: Animals; Aspartic Acid; Carbachol; Cerebellum; Diglycerides; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; N-Methylaspartate; Neurons; Oxadiazoles; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Sphingosine; Tetradecanoylphorbol Acetate | 1988 |
Excitatory amino acid receptors expressed in Xenopus oocytes: agonist pharmacology.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Chlorides; Female; Ibotenic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine; Xenopus | 1988 |
The importance of dopaminergic neurotransmission in the hypermotility response produced by the administration of N-methyl-D-aspartic acid into the nucleus accumbens.
Topics: alpha-Methyltyrosine; Animals; Apomorphine; Aspartic Acid; Dopamine; Dopamine Antagonists; Drug Combinations; Haloperidol; In Vitro Techniques; Locomotion; Male; Methyltyrosines; N-Methylaspartate; Nucleus Accumbens; Pargyline; Potassium; Rats; Rats, Inbred Strains; Reserpine; Septal Nuclei; Synaptic Transmission; Tyrosine 3-Monooxygenase | 1988 |
An intracellular analysis of amino acid induced excitations of deep dorsal horn neurones in the rat spinal cord slice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; Intracellular Membranes; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Spinal Cord; Tetrodotoxin; Valine | 1988 |
Glutamate stimulates somatostatin release from diencephalic neurons in primary culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Diencephalon; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Phencyclidine; Potassium; Quisqualic Acid; Rats; Somatostatin; Tetrodotoxin; Valine; Veratridine | 1988 |
Kynurenate and FG9041 have both competitive and non-competitive antagonist actions at excitatory amino acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cations, Divalent; Cells, Cultured; Glycine; Hippocampus; Ketamine; Kynurenic Acid; Magnesium; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine; Zinc | 1988 |
Role of quisqualic acid receptors in the hypermotility response produced by the injection of AMPA into the nucleus accumbens.
Topics: 2-Aminoadipic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Glutamates; Glutamine; Ibotenic Acid; Injections; Kainic Acid; Locomotion; Male; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles; Oxazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug | 1988 |
Pharmacological induction of use-dependent receptive field modifications in the visual cortex.
Topics: Acetylcholine; Animals; Aspartic Acid; Cats; Glutamates; Glutamic Acid; N-Methylaspartate; Neuronal Plasticity; Neurons; Norepinephrine; Photic Stimulation; Reference Values; Vision, Ocular; Visual Cortex | 1988 |
Epileptiform bursts elicited in CA3 hippocampal neurons by a variety of convulsants are not blocked by N-methyl-D-aspartate antagonists.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Hippocampus; In Vitro Techniques; Kainic Acid; Kindling, Neurologic; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Transient increased density of NMDA binding sites in the developing rat hippocampus.
Topics: Aging; Animals; Aspartic Acid; Autoradiography; Binding, Competitive; Glutamates; Glutamic Acid; Hippocampus; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Behavioral classification of excitatory amino acid receptors in mouse spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Behavior, Animal; Glutamates; Glutamic Acid; Glutamine; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Valine | 1988 |
Tetrahydroaminoacridine selectively attenuates NMDA receptor-mediated neurotoxicity.
Topics: Aminoacridines; Animals; Aspartic Acid; Cells, Cultured; Cholinesterase Inhibitors; Glutamates; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tacrine | 1988 |
Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neural Inhibition; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Synaptic Transmission | 1988 |
Glycine potentiates strychnine-induced convulsions: role of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Drug Synergism; Glycine; Injections, Spinal; Mice; N-Methylaspartate; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Strychnine; Valine | 1988 |
Long-term potentiation differentially affects two components of synaptic responses in hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Evoked Potentials, Somatosensory; Hippocampus; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Synapses; Valine | 1988 |
Kynurenic acid and AP5 distinguish between NMDA receptor agonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Ibotenic Acid; Kynurenic Acid; Mice; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Do N-methyl-D-aspartate receptors mediate synaptic responses in the mudpuppy retina?
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Animals; Aspartic Acid; Electroretinography; Light; N-Methylaspartate; Necturus maculosus; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells; Stereoisomerism; Synapses; Valine | 1988 |
Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Ibotenic Acid; Isoflurane; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Piperazines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Time Factors | 1988 |
Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Glutamates; Glutamic Acid; Glycine; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Selective sparing of NADPH-diaphorase neurons in neonatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Hypoxia; N-Methylaspartate; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; Neurons; Neuropeptide Y; Rats; Rats, Inbred Strains; Somatostatin | 1988 |
Effects of pharmacological manipulations on basal and newly synthesized levels of GABA, glutamate, aspartate and glutamine in mouse brain cortex.
Topics: 2-Amino-5-phosphonovalerate; 3-Mercaptopropionic Acid; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Male; Mice; N-Methylaspartate; Valproic Acid | 1988 |
Amino acid pharmacology in neocortical slices: evidence for bimolecular actions from an extension of the Hill and Gaddum-Schild equations.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Kynurenic Acid; Mathematics; Mice; N-Methylaspartate; Pyridines; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
A comparison between the in vivo and in vitro activity of five potent and competitive NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; In Vitro Techniques; N-Methylaspartate; Neurons; Piperazines; Rats; Reflex; Spine; Valine | 1988 |
NMDA receptor blockade prevents the increase in protein kinase C substrate (protein F1) phosphorylation produced by long-term potentiation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; GAP-43 Protein; Hippocampus; Kinetics; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Reference Values; Valine | 1988 |
6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Glycine; In Vitro Techniques; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Spinal Cord; Strychnine | 1988 |
Epinephrine and norepinephrine modulate neuronal responses to excitatory amino acids and agonists in frog spinal cord.
Topics: Amino Acids; Animals; Aspartic Acid; Epinephrine; Glutamates; Glutamic Acid; In Vitro Techniques; Isoproterenol; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Norepinephrine; Oxadiazoles; Quisqualic Acid; Rana pipiens; Reference Values; Spinal Cord; Yohimbine | 1987 |
Properties of two classes of rat brain acidic amino acid receptors induced by distinct mRNA populations in Xenopus oocytes.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; RNA, Messenger; Xenopus laevis | 1988 |
Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Cerebellum; Electric Stimulation; In Vitro Techniques; Kainic Acid; Magnesium; N-Methylaspartate; Neural Inhibition; Oxadiazoles; Quisqualic Acid; Turtles; Valine | 1988 |
N-methyl-D-aspartate promotes the survival of cerebellar granule cells in culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antigens, Surface; Aspartic Acid; Cell Adhesion Molecules; Cell Survival; Cells, Cultured; Cerebellum; N-Methylaspartate; Nerve Tissue Proteins; Potassium; Rats; Rats, Inbred Strains; Valine | 1988 |
Stimulation of NMDA receptors induces proteolysis of spectrin in hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Calcium Chloride; Evoked Potentials; Hippocampus; Hydrolysis; In Vitro Techniques; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spectrin; Valine | 1988 |
Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-D-aspartate receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Chlorides; Glutamates; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Lithium; Lithium Chloride; N-Methylaspartate; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1988 |
D-aminophosphonovaleric acid-sensitive spontaneous giant EPSPs in immature rat hippocampal neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Piperazines; Rats; Synapses; Tetrodotoxin; Valine | 1988 |
Effect of GABAergic transmission in the subpallidal region on the hypermotility response to the administration of excitatory amino acids and picrotoxin into the nucleus accumbens.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; Aspartic Acid; Basal Ganglia; Brain; gamma-Aminobutyric Acid; Ibotenic Acid; Kainic Acid; Male; Motor Activity; Muscimol; N-Methylaspartate; Nucleus Accumbens; Picrotoxin; Rats; Rats, Inbred Strains; Septal Nuclei; Substantia Innominata; Synaptic Transmission | 1988 |
Evidence for a specific role for cortical NMDA receptors in slow-wave sleep.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Cerebral Cortex; Iontophoresis; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sleep; Valine | 1988 |
Glutamate receptors of ganglion cells in the rabbit retina: evidence for glutamate as a bipolar cell transmitter.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamates; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Light; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Rabbits; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells | 1988 |
A persistent postsynaptic modification mediates long-term potentiation in the hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Glutamates; Hippocampus; Membrane Potentials; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1988 |
No change in neostriatal D-2 dopamine receptors after NMDA lesions of rat prefrontal cortex.
Topics: Animals; Aspartic Acid; Corpus Striatum; Ergolines; Female; Frontal Lobe; Male; N-Methylaspartate; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Tritium | 1986 |
Neuropharmacological actions of kynurenic and quinolinic acids on horizontal cells of the isolated fish retina.
Topics: Animals; Aspartic Acid; Cobalt; Cyprinidae; Evoked Potentials, Visual; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Photic Stimulation; Pyridines; Quinolinic Acid; Quinolinic Acids; Retina | 1986 |
Acute tachycardia and pressor effects following injections of kainic acid into the antero-dorsal medial hypothalamus.
Topics: Animals; Aspartic Acid; Blood Pressure; Heart Rate; Hypothalamus; Injections; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Rats, Inbred Strains | 1987 |
Quinolinate mimics neurotoxic actions of N-methyl-D-aspartate in rat cerebellar slices.
Topics: Animals; Aspartic Acid; Cerebellum; In Vitro Techniques; N-Methylaspartate; Nerve Degeneration; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats | 1987 |
Interactions between topically applied excitatory amino acids on rat cerebral cortex: discrimination by pentobarbitone.
Topics: Administration, Topical; Animals; Aspartic Acid; Cerebral Cortex; Evoked Potentials, Somatosensory; Male; N-Methylaspartate; Oxadiazoles; Pentobarbital; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Rats, Inbred Strains | 1987 |
Hippocampal signal transmission to the pedunculopontine nucleus and its regulation by dopamine D2 receptors in the nucleus accumbens: an electrophysiological and behavioural study.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Action Potentials; Animals; Aspartic Acid; Benzazepines; Brain Mapping; Electric Stimulation; Ergolines; Hippocampus; Hypothalamic Area, Lateral; Male; Motor Activity; N-Methylaspartate; Neural Pathways; Nipecotic Acids; Nucleus Accumbens; Procaine; Proline; Quinpirole; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Dopamine; Receptors, Dopamine D2; Septal Nuclei; Substantia Innominata; Tegmentum Mesencephali | 1987 |
The action of quinolinate in the rat spinal cord in vitro.
Topics: Animals; Anticonvulsants; Aspartic Acid; Convulsants; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Rats, Inbred Strains; Spinal Cord | 1987 |
Autoradiographic characterization of N-methyl-D-aspartate-, quisqualate- and kainate-sensitive glutamate binding sites.
Topics: Animals; Aspartic Acid; Autoradiography; Brain; Brain Mapping; Calcium; Cerebellum; Chlorides; Glutamates; Hippocampus; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1985 |
Activation of NMDA receptors elicits fictive locomotion and bistable membrane properties in the lamprey spinal cord.
Topics: Animals; Aspartic Acid; Electrophysiology; Fishes; In Vitro Techniques; Lampreys; Locomotion; Membrane Potentials; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Tetrodotoxin | 1985 |
Excitatory amino acid pharmacology of the auditory nerve and nucleus magnocellularis of the chicken.
Topics: Amino Acids; Animals; Aspartic Acid; Auditory Pathways; Baclofen; Brain Stem; Chick Embryo; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Neurotransmitter; Vestibulocochlear Nerve | 1985 |
Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Dextrorphan; Ketamine; Levorphanol; Morphinans; N-Methylaspartate; Neurons; Phencyclidine; Rats; Receptors, Opioid; Receptors, sigma; Spinal Cord | 1985 |
Anticonvulsant action of stereoisomers of gamma-glutamylaminomethylsulphonic acid in mice.
Topics: Animals; Anticonvulsants; Aspartic Acid; Glutamates; Glutamine; Kainic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship | 1985 |
Quinolinic acid stimulates luteinizing hormone secretion through a serotonin-dependent mechanism.
Topics: Animals; Aspartic Acid; Castration; Female; Gonadotropin-Releasing Hormone; Hypothalamus, Middle; Luteinizing Hormone; N-Methylaspartate; Norepinephrine; Pituitary Gland, Anterior; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Serotonin; Synaptic Transmission | 1985 |
Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Caudate Nucleus; Electroencephalography; Hypoglycemia; Male; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1985 |
Novel kainic acid analogues. Effects on cyclic GMP content of adult rat cerebellar slices.
Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Cyclic GMP; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Neurotransmitter; Structure-Activity Relationship | 1986 |
In vitro neurotoxicity of excitatory acid analogues during cerebellar development.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Female; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Tetrodotoxin | 1986 |
High correlation between the localization of [3H]TCP binding and NMDA receptors.
Topics: Animals; Aspartic Acid; Autoradiography; Brain; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1986 |
Is Metaphit a phencyclidine antagonist? Studies with ketamine, phencyclidine and N-methylaspartate.
Topics: Action Potentials; Animals; Aspartic Acid; Depression, Chemical; Drug Interactions; Kainic Acid; Ketamine; N-Methylaspartate; Neurons; Oxadiazoles; Phencyclidine; Quisqualic Acid; Rats; Receptors, Opioid; Receptors, sigma; Spinal Cord | 1986 |
Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: dependence on calcium concentration.
Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Golgi Apparatus; Granulocytes; Kainic Acid; N-Methylaspartate; Necrosis; Neurons; Osmolar Concentration; Rats; Receptors, Amino Acid; Receptors, Cell Surface | 1986 |
Intrastriatal N-methyl-D-aspartate prevents amygdala kindled seizures in rats.
Topics: Amygdala; Animals; Aspartic Acid; Corpus Striatum; Depression, Chemical; Kindling, Neurologic; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Seizures; Synaptic Transmission | 1986 |
Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Electroencephalography; Male; N-Methylaspartate; Pilocarpine; Rats; Rats, Inbred Strains; Seizures; Stereotaxic Techniques; Substantia Nigra; Synaptic Transmission | 1986 |
An animal model for neuron-specific spinal cord lesions by the microinjection of N-methylaspartate, kainic acid, and quisqualic acid.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Forelimb; Ganglia, Spinal; Hindlimb; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synaptic Transmission | 1985 |
Excitatory synaptic drive for swimming mediated by amino acid receptors in the lamprey.
Topics: Afferent Pathways; Animals; Aspartic Acid; Efferent Pathways; In Vitro Techniques; Interneurons; Lampreys; N-Methylaspartate; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Swimming; Synapses | 1986 |
The arcuate nucleus: a site for gamma-aminobutyric acid regulation of prolactin secretion.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Aspartic Acid; gamma-Aminobutyric Acid; Male; Muscimol; N-Methylaspartate; Prolactin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Identification and properties of N-methyl-D-aspartate receptors in rat brain synaptic plasma membranes.
Topics: Animals; Aspartic Acid; Autoradiography; Binding, Competitive; Glutamates; Guanine Nucleotides; Hydrogen-Ion Concentration; Kinetics; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Subcellular Fractions; Synaptic Membranes; Temperature | 1986 |
Anatomical organization of excitatory amino acid receptors and their properties.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Autoradiography; Brain; Brain Mapping; Calcium; Glutamates; Humans; N-Methylaspartate; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1986 |
Excitatory amino acid antagonists as novel anticonvulsants.
Topics: Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Aspartic Acid; Epilepsy; Glutamates; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Nervous System Diseases; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Structure-Activity Relationship | 1986 |
2-Amino-7-phosphonoheptanoic acid, a selective N-methyl-D-aspartate antagonist, blocks swim-induced elevation of cerebellar cyclic guanosine monophosphate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Female; Motor Activity; N-Methylaspartate; Rats; Rats, Inbred Strains; Swimming | 1986 |
Muscle relaxant and anticonvulsant activity of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid, a novel N-methyl-D-aspartate antagonist, in rodents.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kainic Acid; Mice; Muscle Relaxants, Central; N-Methylaspartate; Oxadiazoles; Piperazines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex; Time Factors | 1987 |
After-hyperpolarizations produced in frog motoneurons by excitatory amino acid analogues.
Topics: 2,4-Dinitrophenol; Animals; Aspartic Acid; Dinitrophenols; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Ouabain; Oxadiazoles; Potassium; Quisqualic Acid; Ranidae; Sodium; Synaptic Transmission | 1987 |
Ionic mechanisms implicated in the stimulation of cerebellar cyclic GMP levels by N-methyl-D-aspartate.
Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Female; Male; N-Methylaspartate; Nifedipine; Rats; Zinc | 1987 |
Molecular target size of NMDA antagonist binding sites.
Topics: Animals; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Ligands; Molecular Weight; N-Methylaspartate; Phencyclidine; Pyrazines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Evidence that antagonism at non-NMDA receptors results in anticonvulsant action.
Topics: Animals; Anticonvulsants; Aspartic Acid; Glutamates; Glutamine; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Piperazines; Receptors, Amino Acid; Receptors, Cell Surface | 1987 |
A comparison of excitatory amino acid antagonists acting at primary afferent C fibres and motoneurones of the isolated spinal cord of the rat.
Topics: Amino Acids; Animals; Aspartic Acid; In Vitro Techniques; Kainic Acid; Motor Neurons; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Oxadiazoles; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1987 |
Dextrorphan and levorphanol selectively block N-methyl-D-aspartate receptor-mediated neurotoxicity on cortical neurons.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Dextrorphan; Kainic Acid; Levorphanol; Mice; Morphinans; N-Methylaspartate; Neurons; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Ionic changes induced by excitatory amino acids in the rat cerebral cortex.
Topics: Action Potentials; Amino Acids, Diamino; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Cations; Cerebral Cortex; Extracellular Space; Microelectrodes; Motor Cortex; N-Methylaspartate; Potassium; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Sodium; Tetrodotoxin | 1987 |
High concentrations of naloxone attenuate N-methyl-D-aspartate receptor-mediated neurotoxicity.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Female; L-Lactate Dehydrogenase; Mice; N-Methylaspartate; Naloxone; Nervous System Diseases; Oxadiazoles; Pregnancy; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Behavioural effects of N-methyl-D-aspartate in the anterodorsal striatum of the rat.
Topics: Animals; Aspartic Acid; Behavior, Animal; Corpus Striatum; Eating; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Inbred Strains | 1988 |
Both competitive and non-competitive antagonists of N-methyl-D-aspartic acid disrupt brightness discrimination in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Light; Male; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred F344 | 1988 |
Dextromethorphan inhibits NMDA-induced convulsions.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dextromethorphan; Dibenzocycloheptenes; Dizocilpine Maleate; Levorphanol; Male; Mice; N-Methylaspartate; Psychomotor Performance; Seizures | 1988 |
Excitatory amino acids in synaptic excitation of rat striatal neurones in vitro.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Glutamates; Glutamine; In Vitro Techniques; Kynurenic Acid; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Synapses | 1988 |
Neurotoxicity of N-methyl-D-aspartate is markedly enhanced in developing rat central nervous system.
Topics: Aging; Animals; Aspartic Acid; Corpus Striatum; Hippocampus; Microinjections; N-Methylaspartate; Neurotoxins; Rats; Rats, Inbred Strains; Seizures | 1988 |
Excitatory amino acid neurotoxicity in the hippocampal slice preparation.
Topics: Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Microscopy, Electron; N-Methylaspartate; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1988 |
Excitatory amino acids and rod photoreceptor disc shedding: analysis using specific agonists.
Topics: Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; In Vitro Techniques; Kainic Acid; Light; N-Methylaspartate; Oxadiazoles; Phagosomes; Photoreceptor Cells; Pigment Epithelium of Eye; Quisqualic Acid; Rana pipiens; Xenopus laevis | 1988 |
Differential effects of electrolytic and chemical hypothalamic lesions on LH pulses in rats.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Aspartic Acid; Electrolysis; Luteinizing Hormone; Male; N-Methylaspartate; Periodicity; Rats; Rats, Inbred Strains | 1988 |
N-methyl-D-aspartate antagonist MK801 improves outcome following traumatic spinal cord injury in rats: behavioral, anatomic, and neurochemical studies.
Topics: Animals; Aspartic Acid; Blood Pressure; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Intravenous; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord Injuries; Time Factors | 1988 |
Metabolic acidosis induced by N-methyl-D-aspartate in brain slices of the neonatal rat: 31P- and 1H-magnetic resonance spectroscopy.
Topics: Acidosis, Lactic; Animals; Aspartic Acid; Frontal Lobe; Glucose; Hydrogen; Hydrogen-Ion Concentration; In Vitro Techniques; Magnetic Resonance Spectroscopy; N-Methylaspartate; Phosphorus Radioisotopes; Rats | 1988 |
The NMDA antagonists MK801 and CPP disrupt compensation for unilateral labyrinthectomy in the guinea pig.
Topics: Adaptation, Physiological; Afferent Pathways; Animals; Aspartic Acid; Denervation; Dibenzocycloheptenes; Dizocilpine Maleate; Ear, Inner; Guinea Pigs; N-Methylaspartate; Neuronal Plasticity; Nystagmus, Pathologic; Piperazines; Vestibule, Labyrinth | 1988 |
The effects of serotonin on N-methyl-D-aspartate and synaptically evoked depolarizations in rat neocortical neurons.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Evoked Potentials; In Vitro Techniques; N-Methylaspartate; Neurons; Rats; Rats, Inbred F344; Reference Values; Serotonin; Synapses | 1988 |
Equilibrium analysis of [3H]TCP binding: effects of glycine, magnesium and N-methyl-D-aspartate agonists.
Topics: Animals; Aspartic Acid; Binding, Competitive; Cerebral Cortex; Dialysis; Glycine; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Synaptosomes | 1988 |
Evaluation of CPP, a selective NMDA antagonist, in various rodent models of epilepsy. Comparison with other NMDA antagonists, and with diazepam and phenobarbital.
Topics: Amygdala; Animals; Anticonvulsants; Aspartic Acid; Diazepam; Electroshock; Epilepsy; Female; Gerbillinae; Kindling, Neurologic; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Phenobarbital; Piperazines; Psychomotor Performance; Rats; Time Factors | 1988 |
NMDA-induced hippocampal [3H]norepinephrine release is modulated by glycine.
Topics: Animals; Aspartic Acid; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Norepinephrine; Radioligand Assay; Rats | 1988 |
Hypothalamic site of action for N-methyl-D-aspartate (NMDA) on LH secretion.
Topics: Animals; Aspartic Acid; Hypothalamo-Hypophyseal System; Hypothalamus; Luteinizing Hormone; Male; N-Methylaspartate; Organ Specificity; Pituitary Gland; Rats; Rats, Inbred Strains; Reference Values | 1988 |
Sustained intermittent release of gonadotropin-releasing hormone in the prepubertal male rhesus monkey induced by N-methyl-DL-aspartic acid.
Topics: Animals; Aspartic Acid; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Macaca mulatta; Male; N-Methylaspartate; Orchiectomy; Periodicity; Sexual Maturation | 1988 |
Modulation of phospholipid methylation in rat striatum by the corticostriatal pathway.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dopamine; Female; Glutamates; Haloperidol; Kinetics; Methylation; N-Methylaspartate; Phospholipids; Rats; Rats, Inbred Strains; Reference Values | 1988 |
Piriform cortex brain slices: techniques for isolation of synaptic inputs.
Topics: Aminobutyrates; Animals; Aspartic Acid; Cerebral Cortex; Dendrites; Electrophysiology; Evoked Potentials; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Synapses | 1988 |
Respiratory effects of the N-methyl-D-aspartate (NMDA) antagonist, MK-801, in intact and vagotomized chronic cats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Cats; Dibenzocycloheptenes; Dizocilpine Maleate; Electroencephalography; N-Methylaspartate; Pentobarbital; Plethysmography; Respiration; Vagotomy | 1988 |
Inhibitory effect of phencyclidine on rat spinal reflexes.
Topics: Animals; Aspartic Acid; Depression, Chemical; Electric Stimulation; Injections, Intravenous; Male; Motor Neurons; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Reflex; Reflex, Monosynaptic | 1988 |
Effect of antemortem and postmortem factors on [3H]glutamate binding in the human brain.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aspartic Acid; Binding Sites; Cerebral Cortex; Child; Child, Preschool; Female; Glutamates; Humans; Infant; Male; Middle Aged; N-Methylaspartate; Organ Size; Postmortem Changes; Putamen; Time Factors | 1988 |
Changes in voltage dependence of NMDA currents during development.
Topics: Aging; Animals; Aspartic Acid; Electric Conductivity; Hippocampus; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains | 1988 |
Mecamylamine is a selective non-competitive antagonist of N-methyl-D-aspartate- and aspartate-induced currents in horizontal cells dissociated from the catfish retina.
Topics: Animals; Aspartic Acid; Catfishes; Electric Conductivity; In Vitro Techniques; Mecamylamine; Membrane Potentials; N-Methylaspartate; Retina | 1988 |
Opioids and non-opioid enantiomers selectively attenuate N-methyl-D-aspartate neurotoxicity on cortical neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Indicators and Reagents; Methadone; Mice; Morphine; N-Methylaspartate; Naloxone; Narcotics; Neurons; Stereoisomerism | 1988 |
The discriminative stimulus effects of N-methyl-D-aspartate antagonists in phencyclidine-trained rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Discrimination, Psychological; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Methohexital; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Time Factors | 1988 |
Regulation of seizure threshold by excitatory amino acids in the striatum and entopeduncular nucleus of rats.
Topics: Animals; Aspartic Acid; Corpus Striatum; Globus Pallidus; Kainic Acid; Male; N-Methylaspartate; Pilocarpine; Rats; Rats, Inbred Strains; Seizures | 1988 |
6-Hydroxydopamine and excitotoxin lesions of medial prefrontal cortex fail to affect schedule-induced drinking in the rat.
Topics: Animals; Aspartic Acid; Brain Mapping; Dopamine; Drinking Behavior; Food Deprivation; Frontal Lobe; Hydroxydopamines; Male; N-Methylaspartate; Neural Pathways; Nucleus Accumbens; Oxidopamine; Rats; Reinforcement Schedule; Tegmentum Mesencephali | 1986 |
Turning behavior induced by phencyclidine: relationship to antagonism of N-methyl-D-aspartate in the rat striatum.
Topics: Acetylcholine; Animals; Aspartic Acid; Corpus Striatum; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Structure-Activity Relationship | 1986 |
N-methyl-D,L-aspartate elicits hypothalamic gonadotropin-releasing hormone release in prepubertal male rhesus monkeys (Macaca mulatta).
Topics: Animals; Aspartic Acid; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Hydrocortisone; Hypothalamus; Luteinizing Hormone; Macaca mulatta; Male; N-Methylaspartate; Orchiectomy; Sexual Maturation | 1987 |
A voltage clamp study of the glutamate responsive neuromuscular junction in Drosophila melanogaster.
Topics: Action Potentials; Alcohols; Amino Acids; Animals; Aspartic Acid; Drosophila melanogaster; Electrodes; Glutamates; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neuromuscular Junction; Oxadiazoles; Quisqualic Acid | 1988 |
Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release.
Topics: Animals; Aspartic Acid; Catecholamines; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats | 1988 |
Medial prefrontal cortical lesions and baroreceptor heart rate reflex sensitivity in the spontaneously hypertensive rat.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Heart Rate; Hypertension; Male; N-Methylaspartate; Pressoreceptors; Rats; Rats, Inbred SHR; Reflex | 1988 |
The influence of helium pressure on the reduction induced in field potentials by various amino acids and on the GABA-mediated inhibition in the CA1 region of hippocampal slices in the rat.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Atmospheric Pressure; gamma-Aminobutyric Acid; Helium; High Pressure Neurological Syndrome; Hippocampus; In Vitro Techniques; Magnesium; N-Methylaspartate; Neural Inhibition; Rats; Rats, Inbred Strains | 1988 |
Putative serotonergic bipolar and amacrine cells in the chicken retina.
Topics: 5,7-Dihydroxytryptamine; Animals; Aspartic Acid; Chickens; Fluorescent Antibody Technique; Kainic Acid; N-Methylaspartate; Neurotoxins; Retina; Serotonin | 1988 |
Inhibition of N-methyl-D-aspartate evoked sodium flux by MK-801.
Topics: Animals; Anticonvulsants; Aspartic Acid; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Sodium | 1988 |
Developmental changes in neuronal sensitivity to excitatory amino acids in area CA1 of the rat hippocampus.
Topics: Action Potentials; Aging; Animals; Aspartic Acid; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1988 |
Characterization and possible opioid modulation of N-methyl-D-aspartic acid induced increases in serum luteinizing hormone levels in the developing male rat.
Topics: Aging; Animals; Aspartic Acid; Endorphins; Gonadotropin-Releasing Hormone; Hypothalamus; Luteinizing Hormone; Morphine; N-Methylaspartate; Naloxone; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains | 1988 |
The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils.
Topics: Animals; Aspartic Acid; Brain; Female; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Motor Activity; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines | 1988 |
Cloning of the C-terminal cytoplasmic fragment of the tar protein and effects of the fragment on chemotaxis of Escherichia coli.
Topics: Aspartic Acid; Bacterial Proteins; Chemotaxis; Cloning, Molecular; Escherichia coli; Hydrogen-Ion Concentration; Mutation; N-Methylaspartate; Peptide Fragments; Phenotype | 1988 |
Quantitative autoradiography of [3H]-MK-801 binding sites in mammalian brain.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Ischemia; Densitometry; Dibenzocycloheptenes; Dizocilpine Maleate; Gerbillinae; Glutamates; In Vitro Techniques; Muscle, Smooth, Vascular; N-Methylaspartate; Rats; Rats, Inbred Strains; Synaptic Membranes | 1988 |
N-methyl-D-aspartic acid-induced lethality in mice: selective antagonism by phencyclidine-like drugs.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Male; Mice; N-Methylaspartate; Phencyclidine; Rats; Structure-Activity Relationship | 1988 |
Some properties of membrane current fluctuations induced by kainate, quisqualate, and NMDA in cultured septal neurons of rat.
Topics: Animals; Aspartic Acid; Brain; Cells, Cultured; Convulsants; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats | 1988 |
Delayed treatment with dextromethorphan and dextrorphan reduces cerebral damage after transient focal ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Dextromethorphan; Dextrorphan; Levorphanol; Male; Morphinans; N-Methylaspartate; Rabbits | 1988 |
Lateral geniculate lesions block circadian phase-shift responses to a benzodiazepine.
Topics: Animals; Aspartic Acid; Benzodiazepines; Circadian Rhythm; Cricetinae; Geniculate Bodies; Mesocricetus; N-Methylaspartate; Triazolam | 1988 |
Antagonism of N-methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK-801.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Female; Ketamine; Male; N-Methylaspartate; Rats; Synapses; Thalamus | 1988 |
Excitant amino acid projections from rat amygdala and thalamus to nucleus accumbens.
Topics: Amygdala; Animals; Aspartic Acid; Choline; gamma-Aminobutyric Acid; Male; N-Methylaspartate; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Synaptosomes; Thalamus; Tritium | 1988 |
Behavioural, biochemical and histochemical effects of different neurotoxic amino acids injected into nucleus basalis magnocellularis of rats.
Topics: Acetylcholinesterase; Amino Acids; Animals; Aspartic Acid; Basal Ganglia; Behavior, Animal; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Fibers; Female; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Substantia Innominata | 1987 |
Systemic administration of MK-801 prevents N-methyl-D-aspartate-induced neuronal degeneration in rat brain.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Inbred Strains | 1987 |
Responses of pyriform cortex neurons to excitatory amino acids: voltage dependence, conductance changes, and effects of divalent cations.
Topics: Animals; Aspartic Acid; Brain; Cations, Divalent; Convulsants; Electric Stimulation; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Quisqualic Acid; Rats | 1987 |
The N-methyl-D-aspartate antagonist, 2-amino-7-phosphonoheptanoate, produces phencyclidine-like behavioral effects in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1987 |
Folic acid protects chick retinal neurons against the neurotoxic action of excitatory amino acids.
Topics: Animals; Aspartic Acid; Chickens; Dose-Response Relationship, Drug; Folic Acid; Kainic Acid; Microscopy, Electron; N-Methylaspartate; Neurons; Oxadiazoles; Quinolinic Acids; Quisqualic Acid; Retina | 1987 |
Stimulation of substantia nigra pars reticulata enhances dentate granule cell excitability.
Topics: Action Potentials; Animals; Aspartic Acid; Electric Stimulation; Hippocampus; Male; N-Methylaspartate; Neural Pathways; Rats; Rats, Inbred Strains; Substantia Nigra | 1987 |
The role of substantia nigra in the development of kindling: pharmacologic and lesion studies.
Topics: Aminocaproates; Animals; Aspartic Acid; Kindling, Neurologic; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Substantia Nigra; Vigabatrin | 1987 |
Effects of L-cysteine-sulphinate and L-aspartate, mixed excitatory amino acid agonists, on the membrane potential of cat caudate neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cats; Caudate Nucleus; Cysteine; Female; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid | 1987 |
Non-pharmacological effects of the use of microelectrophoresis and pressure ejection of drugs in combination.
Topics: Amino Acids; Animals; Aspartic Acid; Electrophoresis; Ibotenic Acid; Kainic Acid; Microelectrodes; N-Methylaspartate; Neurons; Nifedipine; Oxadiazoles; Quisqualic Acid; Rats; Spinal Cord | 1987 |
Anticonvulsant action and biochemical effects in DBA/2 mice of CPP (3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonate), a novel N-methyl-D-aspartate antagonist.
Topics: Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain Chemistry; Female; Glucose; Lactates; Lactic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Piperazines | 1987 |
Effect of N-methyl-D-aspartate applied to the ventral surface of the medulla on the trachea.
Topics: Animals; Aspartic Acid; Cats; Electric Stimulation; Female; Male; Medulla Oblongata; N-Methylaspartate; Phrenic Nerve; Pressure; Trachea | 1987 |
Activation of luteinizing hormone-releasing hormone release advances the onset of female puberty.
Topics: Animals; Aspartic Acid; Female; Gonadotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Luteinizing Hormone; N-Methylaspartate; Rats; Rats, Inbred Strains; Sexual Maturation | 1987 |
Characterization of motor activity patterns induced by N-methyl-D-aspartate antagonists in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electronic Data Processing; Female; Gerbillinae; Ketamine; Motor Activity; N-Methylaspartate; Pipecolic Acids; Piperazines; Piperidines; Time Factors | 1987 |
MK-801 powerfully protects against N-methyl aspartate neurotoxicity.
Topics: Animals; Anticonvulsants; Aspartic Acid; Autoradiography; Binding, Competitive; Chick Embryo; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Kainic Acid; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains | 1987 |
Phosphoethanolamine transiently enhances excitability of rat hippocampal neurons in vitro.
Topics: Animals; Aspartic Acid; Electrophysiology; Ethanolamines; Female; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neurons; Rats; Synapses | 1987 |
Medial prefrontal cortical lesions modulate baroreflex sensitivity in the rat.
Topics: Animals; Aspartic Acid; Blood Pressure; Body Weight; Cerebral Cortex; Heart Rate; Male; N-Methylaspartate; Nitroprusside; Phenylephrine; Pressoreceptors; Rats; Rats, Inbred Strains; Reflex; Stereotaxic Techniques | 1987 |
Selective loss of Purkinje and granule cell responsiveness to N-methyl-D-aspartate in rat cerebellum during development.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Convulsants; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats | 1987 |
Phencyclidine analogues inhibit NMDA-stimulated [3H]GABA release from cultured cortex neurons.
Topics: Animals; Aspartic Acid; Binding, Competitive; Cerebral Cortex; gamma-Aminobutyric Acid; In Vitro Techniques; N-Methylaspartate; Neurons; Phencyclidine; Rats | 1987 |
The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cells, Cultured; Corpus Striatum; Glutamates; In Vitro Techniques; Kainic Acid; Magnesium; Mice; N-Methylaspartate; Neurons; Oxadiazoles; Permeability; Quisqualic Acid | 1987 |
Tiletamine is a potent inhibitor of N-methyl-aspartate-induced depolarizations in rat hippocampus and striatum.
Topics: Acetylcholine; Action Potentials; Animals; Aspartic Acid; Corpus Striatum; Cyclohexanes; Hippocampus; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Tetrodotoxin; Tiletamine | 1987 |
Unique behavioral effects of the NMDA antagonist, CPP, upon injection into the medial pre-frontal cortex of rats.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Cerebral Ventricles; Injections, Intraventricular; Kinetics; Male; Motor Activity; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Time Factors | 1987 |
L-homocysteate is a potent neurotoxin on cultured cortical neurons.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebral Cortex; Extracellular Space; Homocysteine; Mice; N-Methylaspartate; Neurons; Neurotoxins; Osmolar Concentration; Sodium; Time Factors | 1987 |
Helium pressure potentiates the N-methyl-D-aspartate- and D,L-homocysteate-induced decreases of field potentials in the rat hippocampal slice preparation.
Topics: Action Potentials; Air Pressure; Amino Acids; Animals; Aspartic Acid; Helium; Hippocampus; Homocysteine; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains | 1987 |
Pharmacological protection against the toxicity of N-methyl-D-aspartate in immature rat cerebellar slices.
Topics: Animals; Aspartic Acid; Aspirin; Calcium Channel Blockers; Cerebellum; Female; In Vitro Techniques; Indomethacin; Kynurenic Acid; Leupeptins; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Taurine | 1987 |
Glycine potentiates N-methyl-D-aspartate-induced [3H]TCP binding to rat cortical membranes.
Topics: Animals; Aspartic Acid; Cell Membrane; Cerebral Cortex; Drug Synergism; Electric Stimulation; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1987 |
2-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) selectively antagonises N-methyl-aspartate (NMA).
Topics: Anesthetics; Anesthetics, Dissociative; Animals; Anura; Aspartic Acid; In Vitro Techniques; Kainic Acid; Ketamine; Medulla Oblongata; N-Methylaspartate; Neurons; Oxadiazoles; Phenylpropanolamine; Quisqualic Acid; Rats; Spinal Cord | 1986 |
Induction of audiogenic seizure susceptibility by focal infusion of excitant amino acid or bicuculline into the inferior colliculus of normal rats.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Bicuculline; Inferior Colliculi; Male; Microinjections; N-Methylaspartate; Rats; Rats, Inbred Strains; Seizures; Superior Colliculi | 1986 |
Distribution of neuropeptide Y immunoreactivity in the rat basal ganglia: effects of excitotoxin lesions to caudate-putamen.
Topics: Animals; Aspartic Acid; Basal Ganglia; Brain Diseases; Caudate Nucleus; Male; N-Methylaspartate; Nerve Tissue Proteins; Neuropeptide Y; Putamen; Radioimmunoassay; Rats; Rats, Inbred Strains; Tissue Distribution | 1986 |
The primary afferent depolarizing action of kainate in the rat.
Topics: Action Potentials; Afferent Pathways; Animals; Aspartic Acid; Capsaicin; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Oxadiazoles; Quisqualic Acid; Rats; Spinal Nerve Roots | 1986 |
N-methylaspartate: an effective tool for lesioning basal forebrain cholinergic neurons of the rat.
Topics: Animals; Aspartic Acid; Basal Ganglia; Choline O-Acetyltransferase; Cholinergic Fibers; Female; Immunoenzyme Techniques; N-Methylaspartate; Rats; Rats, Inbred Strains | 1986 |
Actions of phencyclidine on rat locus coeruleus neurones in vitro.
Topics: Action Potentials; Animals; Aspartic Acid; Cell Count; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Evoked Potentials; Locus Coeruleus; Male; Membrane Potentials; N-Methylaspartate; Neurons; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Stereoisomerism; Time Factors | 1986 |
Spontaneous paroxysmal activity induced by zero magnesium and bicuculline: suppression by NMDA antagonists and GABA mimetics.
Topics: Animals; Aspartic Acid; Baclofen; Bicuculline; Corpus Callosum; gamma-Aminobutyric Acid; In Vitro Techniques; Magnesium; N-Methylaspartate; Neuromuscular Depolarizing Agents; Rats; Rats, Inbred Strains | 1986 |
The anti-excitotoxic effects of certain anesthetics, analgesics and sedative-hypnotics.
Topics: Analgesics; Anesthetics; Animals; Aspartic Acid; Chick Embryo; Hypnotics and Sedatives; Kainic Acid; N-Methylaspartate; Neurotoxins; Retina | 1986 |
Reversible and irreversible neuronal damage caused by excitatory amino acid analogues in rat cerebellar slices.
Topics: Animals; Aspartic Acid; Cerebellar Cortex; Cerebellar Diseases; Cerebellar Nuclei; Female; In Vitro Techniques; Kainic Acid; Male; Microscopy, Electron; N-Methylaspartate; Purkinje Cells; Rats; Rats, Inbred Strains | 1986 |
Ionic requirements for neurotoxic effects of excitatory amino acid analogues in rat cerebellar slices.
Topics: Animals; Aspartic Acid; Calcium; Cerebellar Diseases; Cerebellum; Chlorides; Female; In Vitro Techniques; Kainic Acid; Male; Microscopy, Electron; N-Methylaspartate; Rats; Rats, Inbred Strains; Sodium | 1986 |
Amino acid neurotoxicity: relationship to neuronal depolarization in rat cerebellar slices.
Topics: Age Factors; Animals; Aspartic Acid; Cerebellar Diseases; Female; In Vitro Techniques; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate; Ouabain; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Veratridine | 1986 |
O-phosphohomoserine, a naturally occurring analogue of phosphonate amino acid antagonists, is an N-methyl-D-aspartate (NMDA) antagonist in rat hippocampus.
Topics: Animals; Aspartic Acid; Drug Interactions; Evoked Potentials; Hippocampus; Homoserine; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats | 1986 |
Neurotoxic lesions of the paraventriculo-spinal projection block the nocturnal rise in pineal melatonin synthesis in the Syrian hamster.
Topics: Animals; Aspartic Acid; Cricetinae; Efferent Pathways; Male; Medial Forebrain Bundle; Melatonin; Mesocricetus; N-Methylaspartate; Paraventricular Hypothalamic Nucleus; Pineal Gland; Spinal Cord | 1986 |
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding Sites; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Ketamine; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains | 1986 |
Effect of excitotoxin lesions in the medical prefrontal cortex on cortical and subcortical catecholamine turnover in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Aspartic Acid; Catecholamines; Cerebral Cortex; Dopamine; Male; Methoxyhydroxyphenylglycol; Methyltyrosines; N-Methylaspartate; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Tegmentum Mesencephali | 1986 |
Laminar profiles of the changes in extracellular calcium concentration induced by repetitive stimulation and excitatory amino acids in the rat dentate gyrus.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Electric Stimulation; Hippocampus; Iontophoresis; Male; Membrane Potentials; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1986 |
Ketamine selectively suppresses synchronized afterdischarges in immature hippocampus.
Topics: Aging; Animals; Aspartic Acid; Evoked Potentials; Hippocampus; Iontophoresis; Ketamine; Membrane Potentials; N-Methylaspartate; Neural Inhibition; Neurons; Penicillins; Rats | 1986 |
N-methyl-D-aspartate and hypoxia induced Ca2+-changes in the CA1 region of the hippocampal slice.
Topics: Animals; Aspartic Acid; Calcium; Guinea Pigs; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate | 1986 |
Effects of GABA and bicuculline on N-methyl-D-aspartate- and quisqualate-induced reductions in extracellular free calcium in area CA1 of the hippocampal slice.
Topics: Animals; Aspartic Acid; Bicuculline; Calcium; Drug Interactions; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1986 |
Serotonin facilitates NMDA responses of cat neocortical neurones.
Topics: Animals; Aspartic Acid; Cats; Cerebral Cortex; Female; Iontophoresis; Male; Membrane Potentials; N-Methylaspartate; Neurons; Serotonin | 1986 |
Method of lesioning brainstem determines seizure probability.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain Stem; Electric Injuries; Hot Temperature; Male; N-Methylaspartate; Neurology; Rats; Rats, Inbred Strains; Seizures | 1986 |
Amino acid neurotoxicity: intracellular sites of calcium accumulation associated with the onset of irreversible damage to rat cerebellar neurones in vitro.
Topics: Animals; Aspartic Acid; Calcium; Cell Nucleus; Cerebellum; Golgi Apparatus; In Vitro Techniques; Microscopy, Electron; N-Methylaspartate; Nerve Degeneration; Organoids; Rats | 1986 |
Role of the substantia nigra in the kindling model of limbic epilepsy.
Topics: Animals; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Kindling, Neurologic; Limbic System; Muscimol; N-Methylaspartate; Rats; Substantia Nigra | 1986 |
Alterations in extracellular amino acids and Ca2+ following excitotoxin administration and during status epilepticus.
Topics: Amino Acids; Animals; Aspartic Acid; Bicuculline; Calcium; Epilepsy; Ethanolamines; Extracellular Space; Glutamates; Hippocampus; Kainic Acid; N-Methylaspartate; Rabbits; Synaptic Membranes; Synaptosomes; Taurine; Tetrodotoxin | 1986 |
Long-term alterations in amino acid-induced ionic conductances in chronic epilepsy.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cobalt; Electric Conductivity; Epilepsy; Glutamates; Kainic Acid; Motor Cortex; N-Methylaspartate; Oxadiazoles; Pyramidal Tracts; Quisqualic Acid; Rats; Sodium | 1986 |
Excitatory amino acids and epilepsy-induced changes in extracellular space size.
Topics: Animals; Aspartic Acid; Cats; Epilepsy; Extracellular Space; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuroglia; Oxadiazoles; Potassium; Quisqualic Acid; Somatosensory Cortex; Water-Electrolyte Balance | 1986 |
Effects of kainate on CA1 hippocampal neurons recorded in vitro.
Topics: Action Potentials; Animals; Aspartic Acid; Calcium; Electric Conductivity; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Potassium | 1986 |
A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Diazepam; Electroencephalography; Hippocampus; Injections; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1986 |
N-methyl-D-aspartate produces discriminative stimuli in rats.
Topics: Animals; Aspartic Acid; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Rats; Rats, Inbred Strains | 1987 |
Evidence that neurons of the paraventricular nucleus of the hypothalamus with projections to the spinal cord are sensitive to the toxic effects of N-methyl aspartic acid.
Topics: Animals; Aspartic Acid; Cricetinae; Horseradish Peroxidase; Male; N-Methylaspartate; Neural Pathways; Paraventricular Hypothalamic Nucleus; Spinal Cord | 1987 |
N-acetyl-aspartylglutamate: binding sites and excitatory action in the dorsolateral septum of rats.
Topics: Action Potentials; Animals; Aspartic Acid; Autoradiography; Binding Sites; Dipeptides; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Septal Nuclei | 1987 |
Unusual interactions of excitatory amino acid receptor agonists: alpha- and beta-kainate antagonize motor responses to N-methyl-D-aspartate in rodents.
Topics: Animals; Aspartic Acid; Electromyography; Kainic Acid; Male; Mice; Motor Activity; Muscle Spasticity; Muscle Tonus; N-Methylaspartate; Seizures; Stereoisomerism | 1987 |
Paradoxical anticonvulsant activity of the excitatory amino acid N-methyl-D-aspartate in the rat caudate-putamen.
Topics: Animals; Anticonvulsants; Aspartic Acid; Caudate Nucleus; Epilepsy; Ibotenic Acid; Male; N-Methylaspartate; Pilocarpine; Putamen; Rats; Rats, Inbred Strains; Substantia Nigra | 1987 |
The occurrence of N-methyl-D-aspartic acid in muscle extracts of the blood shell, Scapharca broughtonii.
Topics: Animals; Aspartic Acid; Electrophoresis, Paper; Mollusca; Muscles; N-Methylaspartate | 1987 |
N-methyl-D,L-aspartate-induced locomotor activity in a spinal cord-hindlimb muscles preparation of the newborn rat studied in vitro.
Topics: Animals; Animals, Newborn; Aspartic Acid; Hindlimb; In Vitro Techniques; Motor Activity; N-Methylaspartate; Neuromuscular Junction; Neurons; Rats; Rats, Inbred Strains; Spinal Cord | 1987 |
Dopamine inhibits calcium-independent gamma-[3H]aminobutyric acid release induced by kainate and high K+ in the fish retina.
Topics: Animals; Aspartic Acid; Bicuculline; Calcium; Dopamine; Fishes; gamma-Aminobutyric Acid; Haloperidol; Kainic Acid; N-Methylaspartate; Oxadiazoles; Picrotoxin; Potassium; Pyrrolidines; Quisqualic Acid; Retina; Serotonin | 1985 |
Antagonism of N-methyl-D,L-aspartic acid-induced convulsions by antiepileptic drugs and other agents.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dose-Response Relationship, Drug; Injections, Intravenous; Injections, Subcutaneous; Male; Mice; N-Methylaspartate; Seizures | 1985 |
Neurotoxic lesions of the anterior hypothalamus disrupt the photoperiodic but not the circadian system of the Syrian hamster.
Topics: Animals; Aspartic Acid; Circadian Rhythm; Cricetinae; Estrus; Female; Hypothalamus, Anterior; Light; Male; Mesocricetus; Motor Activity; N-Methylaspartate; Periodicity; Pregnancy; Seasons; Sexual Behavior, Animal | 1985 |
Pharmacological activation of locomotor patterns in larval and adult frog spinal cords.
Topics: 2-Aminoadipic Acid; 5-Hydroxytryptophan; Animals; Apomorphine; Aspartic Acid; Benserazide; Clonidine; In Vitro Techniques; Larva; Levodopa; Locomotion; N-Methylaspartate; Nialamide; Rana catesbeiana; Rana pipiens; Spinal Cord | 1985 |
Anticonvulsant activity of two novel piperazine derivatives with potent kainate antagonist activity.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Aspartic Acid; Chemical Phenomena; Chemistry; Glutamates; Kainic Acid; Mice; Mice, Inbred DBA; Mice, Inbred Strains; N-Methylaspartate; Oxadiazoles; Piperazines; Pyrrolidines; Quinolinic Acids; Quisqualic Acid; Seizures | 1985 |
The effect of current passage on N-methyl-D-aspartate-induced, tetrodotoxin-resistant membrane potential oscillations in lamprey neurons active during locomotion.
Topics: Animals; Anterior Horn Cells; Aspartic Acid; Electric Stimulation; Fishes; In Vitro Techniques; Interneurons; Lampreys; Locomotion; Membrane Potentials; N-Methylaspartate; Spinal Cord; Tetrodotoxin | 1985 |
Effect of ketamine on amino acid-evoked release of acetylcholine from rat cerebral cortex in vitro.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Dose-Response Relationship, Drug; In Vitro Techniques; Kainic Acid; Ketamine; Magnesium; N-Methylaspartate; Potassium Chloride; Rats | 1985 |
Degeneration of cholinergic neurons in the basal nucleus following kainic or N-methyl-D-aspartic acid application to the cerebral cortex in the rat.
Topics: Animals; Aspartic Acid; Basal Ganglia; Cerebral Cortex; Cholinergic Fibers; Kainic Acid; N-Methylaspartate; Neural Pathways; Pyrrolidines; Rats; Rats, Inbred Strains; Substantia Innominata | 1985 |
N-Methylaspartate-evoked liberation of taurine and phosphoethanolamine in vivo: site of release.
Topics: Animals; Aspartic Acid; Calcium; Cobalt; Ethanolamines; Hippocampus; N-Methylaspartate; Potassium; Rabbits; Synaptosomes; Taurine | 1985 |
An intracellular study of the interactions of N-methyl-DL-aspartate with ketamine in the mouse hippocampal slice.
Topics: Action Potentials; Animals; Aspartic Acid; Drug Interactions; Hippocampus; In Vitro Techniques; Kainic Acid; Ketamine; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Oxadiazoles; Quisqualic Acid | 1985 |
Threshold effects of N-methyl D-aspartate (NMDA) and 2-amino 5-phosphono valeric acid (2APV) on the spontaneous activity of neocortical single neurones in the urethane anaesthetised rat.
Topics: Action Potentials; Animals; Aspartic Acid; Evoked Potentials, Somatosensory; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Somatosensory Cortex | 1985 |
Light and electron microscopic evidence of transneuronal labeling with WGA-HRP to trace somatosensory pathways to the thalamus.
Topics: Animals; Aspartic Acid; Cats; Horseradish Peroxidase; Lectins; Male; Microscopy, Electron; N-Methylaspartate; Rats; Somatosensory Cortex; Spinal Cord; Thalamus; Time Factors; Wheat Germ Agglutinins | 1985 |
Differences of neuronal sensitivity to amino acids and related compounds in the rat hippocampal slice.
Topics: Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Neurons; Quinolinic Acids; Rats; Rats, Inbred Strains | 1985 |
Separation of the motor consequences from other actions of unilateral 6-hydroxydopamine lesions in the nigrostriatal neurones of rat brain.
Topics: Animals; Aspartic Acid; Conditioning, Operant; Corpus Striatum; Functional Laterality; Hydroxydopamines; Injections, Intraventricular; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Nerve Crush; Neural Pathways; Neurons; Neurotoxins; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
Neurotoxic amino acid lesions of the lateral hypothalamus: a parametric comparison of the effects of ibotenate, N-methyl-D,L-aspartate and quisqualate in the rat.
Topics: Animals; Aspartic Acid; Dopamine; Hypothalamic Area, Lateral; Ibotenic Acid; Male; Mesencephalon; N-Methylaspartate; Neural Pathways; Oxadiazoles; Oxazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Serotonin | 1985 |
The neurotoxicity of excitatory amino acids is produced by passive chloride influx.
Topics: Animals; Aspartic Acid; Calcimycin; Calcium; Cell Survival; Chlorides; Glutamates; Hippocampus; Kainic Acid; N-Methylaspartate; Neurons; Potassium; Pyrrolidines; Rodentia | 1985 |
Comparison of sigma- and kappa-opiate receptor ligands as excitatory amino acid antagonists.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Cats; Cyclazocine; Ethylketocyclazocine; Kainic Acid; Ketamine; Ligands; Microelectrodes; N-Methylaspartate; Neurons; Oxadiazoles; Phenazocine; Quisqualic Acid; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, sigma; Stereoisomerism | 1984 |
N-Methyl-D-aspartate and L-aspartate activate distinct receptors in piriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Drug Interactions; Limbic System; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1984 |
Isomers of cyclazocine as excitatory amino acid antagonists.
Topics: Animals; Aspartic Acid; Cats; Cerebral Cortex; Cyclazocine; Electrophysiology; In Vitro Techniques; N-Methylaspartate; Neurons; Ranidae; Rats; Receptors, Opioid; Spinal Cord; Stereoisomerism | 1984 |
Electrophysiological studies on neuronal transmission in the frog's photosensory pineal organ. The effect of amino acids and biogenic amines.
Topics: 2-Aminoadipic Acid; Acetylcholine; Action Potentials; Amino Acids; Animals; Aspartic Acid; Biogenic Amines; Dose-Response Relationship, Drug; Glutamates; Kainic Acid; N-Methylaspartate; Neurons; Photic Stimulation; Photoreceptor Cells; Pineal Gland; Rana esculenta; Serotonin; Synaptic Transmission; Taurine | 1984 |
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anura; Aspartic Acid; Cats; Evoked Potentials; N-Methylaspartate; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Synapses | 1981 |
Pharmacological antagonists of excitant amino acid action.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aspartic Acid; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Receptors, Drug; Structure-Activity Relationship | 1981 |
Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Drug Antagonism; Electric Conductivity; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; N-Methylaspartate; Neurons; Organophosphorus Compounds; Rats; Valine | 1981 |
D-aminophosphonovalerate is 100-fold more powerful than D-alpha-aminoadipate in blocking N-methylaspartate neurotoxicity.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Female; Hypothalamus; Male; Mice; N-Methylaspartate; Neurons; Organophosphorus Compounds; Structure-Activity Relationship; Valine | 1981 |
Stimulation of rat cerebellar guanosine 3',5'-cyclic monophosphate (cyclic GMP) levels: effects of amino acid antagonists.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cerebellum; Cyclic GMP; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Protoveratrines; Rats; Rats, Inbred Strains | 1981 |
Specific and non-specific effects of neuro-excitatory amino acids on learning and other behaviours in the chicken.
Topics: Aggression; Aging; Animals; Aspartic Acid; Behavior, Animal; Chickens; Copulation; Glutamates; Glutamic Acid; Habituation, Psychophysiologic; Humans; Kainic Acid; Learning; N-Methylaspartate; Pattern Recognition, Visual; Pyrrolidines; Visual Perception | 1982 |
The action of six antagonists of the excitatory amino acids on neurones of the rat spinal cord.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Rats; Spinal Cord; Structure-Activity Relationship | 1982 |
Activity of the enantiomers of 2-amino-5-phosphono-valeric acid as stereospecific antagonists of excitatory aminoacids.
Topics: Adipates; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Rats; Stereoisomerism; Synaptic Transmission | 1981 |
2-amino-4-phosphonobutyric acid and N-methyl-D-aspartate differentiate between "3H]glutamate and [3H] aspartate binding sites in bovine retina.
Topics: Aminobutyrates; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cattle; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; N-Methylaspartate; Neurons; Retina; Synaptic Membranes | 1982 |
Methylation at D-aspartyl residues in erythrocytes: possible step in the repair of aged membrane proteins.
Topics: Amino Acid Oxidoreductases; Aspartic Acid; D-Amino-Acid Oxidase; Erythrocyte Aging; Erythrocyte Membrane; Erythrocytes; Humans; Membrane Proteins; Methylation; N-Methylaspartate | 1982 |
Some effects of excitatory amino acid receptor antagonists on synaptic transmission in the rat olfactory cortex slice.
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Animals; Aspartic Acid; Culture Techniques; Dipeptides; Electric Stimulation; Evoked Potentials; N-Methylaspartate; Olfactory Bulb; Olfactory Pathways; Pipecolic Acids; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Valine | 1982 |
Conductance changes induced by DL-homocysteic acid and N-methyl-DL-aspartic acid in hippocampal neurons.
Topics: Animals; Aspartic Acid; Cell Membrane; Electric Conductivity; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Homocysteine; In Vitro Techniques; Iontophoresis; Manganese; N-Methylaspartate; Tetrodotoxin | 1982 |
Actions of N-methyl aspartate and its antagonist aminophosphonovalerate on the A5 catecholamine cell group in rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Blood Pressure; Brain; Dose-Response Relationship, Drug; Female; Heart Rate; Male; N-Methylaspartate; Neurons; Rats; Receptors, Adrenergic; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Valine | 1982 |
Differential activation and blockade of excitatory amino acid receptors in the mammalian and amphibian central nervous systems.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cats; In Vitro Techniques; N-Methylaspartate; Ranidae; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Synapses | 1982 |
Effect of urethane on synaptic and amino acid-induced excitation in isolated spinal cord preparations.
Topics: Animals; Aspartic Acid; Evoked Potentials; Ganglia, Spinal; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Ranidae; Rats; Spinal Cord; Synapses; Urethane | 1982 |
Characterization of the excitatory amino acid receptor-mediated release of [3H]acetylcholine from rat striatal slices.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Afferent Pathways; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Interneurons; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine | 1982 |
Excitatory amino acid receptors and guanosine 3',5'-cyclic monophosphate in incubated slices of immature and adult rat cerebellum.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Rats; Receptors, Amino Acid; Receptors, Cell Surface | 1982 |
Effects of D-alpha-aminoadipate on excitation of afferent fibers in the lateral line of Xenopus laevis.
Topics: 2-Aminoadipic Acid; Afferent Pathways; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Female; Glutamates; Glutamic Acid; Hair Cells, Auditory; Kainic Acid; Male; Mechanoreceptors; Motor Activity; N-Methylaspartate; Synaptic Transmission; Xenopus laevis | 1982 |
Selective antagonist activity of 5-aminohex-2-enedioic acid on amino acid excitation of cat spinal neurones.
Topics: 2-Aminoadipic Acid; Amino Acids; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Cats; Glutamates; Glutamic Acid; Interneurons; N-Methylaspartate; Neurons; Spinal Cord; Structure-Activity Relationship | 1980 |
Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Stem; Cells, Cultured; Embryo, Mammalian; Glutamates; Ibotenic Acid; N-Methylaspartate; Oxazoles; Rats; Receptors, Cell Surface; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine | 1983 |
Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro.
Topics: Absorption; Amino Acids; Animals; Aspartic Acid; Calcium; Cerebral Cortex; Glutamates; Glutamic Acid; Homocysteine; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Rats | 1983 |
The antagonism of amino acid-induced excitations of rat hippocampal CA1 neurones in vitro.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Action Potentials; Amino Acids; Animals; Aspartic Acid; Dipeptides; Hippocampus; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Valine | 1983 |
The role of excitatory amino acid transmitters in the mudpuppy retina: an analysis with kainic acid and N-methyl aspartate.
Topics: Animals; Aspartic Acid; Glutamates; Kainic Acid; N-Methylaspartate; Necturus; Neurons; Neurotransmitter Agents; Photoreceptor Cells; Pyrrolidines; Receptors, Cell Surface; Retina; Retinal Ganglion Cells | 1983 |
Presence of N-methyl-D-aspartate-like and kainate-like activities in bovine brain.
Topics: Animals; Aspartic Acid; Brain Chemistry; Carbon Radioisotopes; Cattle; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Pyrrolidines | 1983 |
Excitatory amino acids: modes of action on hippocampal pyramidal cells.
Topics: Action Potentials; Animals; Aspartic Acid; Calcium; Electric Conductivity; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Ion Channels; Membrane Potentials; N-Methylaspartate; Potassium; Receptors, Cell Surface; Receptors, Glutamate; Synapses | 1983 |
Neuroactive amino acids influence gonadotrophin output by a suprapituitary mechanism in either rodents or primates.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Luteinizing Hormone; Macaca fascicularis; Macaca nemestrina; Male; N-Methylaspartate; Papio; Rats; Rats, Inbred Strains | 1983 |
Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Evoked Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Rats; Synapses; Valine | 1983 |
Effects of excitatory amino acids on locomotor activity after bilateral microinjection into the rat nucleus accumbens: possible dependence on dopaminergic mechanisms.
Topics: Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Seizures; Septal Nuclei; Synaptic Transmission | 1983 |
A comparison of the anticonvulsant potency of (+/-) 2-amino-5-phosphonopentanoic acid and (+/-) 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Rats; Rats, Inbred Strains; Seizures; Valine | 1983 |
Effects of excitatory amino acids on dopamine synthesis in the rat retina.
Topics: Amino Acids; Animals; Aspartic Acid; Dopamine; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Retina | 1983 |
Voltage clamp analysis of the effect of excitatory amino acids and derivatives on Purkinje cell dendrites in rat cerebellar slices maintained in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Culture Techniques; Dendrites; Glutamates; Glutamic Acid; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Synaptic Transmission | 1983 |
Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Aspartic Acid; Evoked Potentials; Folic Acid; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neural Pathways; Oxadiazoles; Pyrrolidines; Quisqualic Acid; Rats | 1983 |
N-methyl aspartate activates voltage-dependent calcium conductance in rat hippocampal pyramidal cells.
Topics: Action Potentials; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Ion Channels; N-Methylaspartate; Neural Conduction; Neurons; Potassium; Rats | 1983 |
Effects of excitatory amino acids, and of their agonists and antagonists on the release of neurotransmitters from the chick retina.
Topics: Amino Acids; Animals; Aspartic Acid; Chickens; Cysteic Acid; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Endings; Neurotransmitter Agents; Receptors, Neurotransmitter; Retina; Synapses; Synaptic Transmission | 1983 |
Differential sensitivity of selected brain areas to excitatory amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Rats; Sodium; Stimulation, Chemical | 1983 |
Amino acid neurotransmission between fimbria-fornix fibers and neurons in the lateral septum of the rat: a microiontophoretic study.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamates; Hippocampus; Iontophoresis; Male; N-Methylaspartate; Nerve Fibers; Neural Pathways; Neuromuscular Junction; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Septal Nuclei; Synaptic Transmission; Valine | 1984 |
On the sensitivity of H1 horizontal cells of the carp retina to glutamate, aspartate and their agonists.
Topics: Animals; Aspartic Acid; Carps; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Retina | 1984 |
The halomethylketone derivative L-Glu-gamma-DL-Ala-CH2Cl and N-methyl-D-aspartate as selective antagonists against L-glutamate and kainate excitation respectively on Retzius cells of the leech, Hirudo medicinalis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Ganglia; Kainic Acid; Leeches; Membrane Potentials; N-Methylaspartate; Pyrrolidines; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1984 |
l-Glutamate reduces the affinity of [3H]N-propylnorapomorphine binding sites in striatal membranes.
Topics: Animals; Antiparkinson Agents; Apomorphine; Aspartic Acid; Binding Sites; Cell Membrane; Corpus Striatum; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Spiperone | 1984 |
A comparison of the effects of N-methyl-D-aspartate and quinolinate on central neurones of the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Iontophoresis; Microinjections; N-Methylaspartate; Neurons; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Somatosensory Cortex; Spinal Cord; Stimulation, Chemical; Valine | 1984 |
Effect of excitatory amino acids on Purkinje cell dendrites in cerebellar slices from normal and staggerer mice.
Topics: Amino Acids; Animals; Aspartic Acid; Crosses, Genetic; Dendrites; Glutamates; Glutamic Acid; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Neurologic Mutants; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid | 1984 |
The effect of the dioxolanes on amino acid induced excitation in the mammalian spinal cord.
Topics: Animals; Aspartic Acid; Cats; Dioxolanes; Dioxoles; Kainic Acid; Ketamine; N-Methylaspartate; Oxadiazoles; Phencyclidine; Quisqualic Acid; Rats; Species Specificity; Spinal Cord; Stereoisomerism; Structure-Activity Relationship | 1984 |
Mixed-agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Culture Techniques; Electric Conductivity; Glutamates; Glutamic Acid; Homocysteine; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Spinal Cord; Valine | 1984 |
The effect of D-alpha-aminoadipate on excitatory amino acid responses recorded intracellularly from motoneurones of the frog spinal cord.
Topics: 2-Aminoadipic Acid; Amino Acids; Amino Acids, Dicarboxylic; Animals; Anterior Horn Cells; Aspartic Acid; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana temporaria; Spinal Nerve Roots | 1984 |
Selective association of N-methyl aspartate and quisqualate types of L-glutamate receptor with brain postsynaptic densities.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Chlorides; Glutamates; Glutamic Acid; Kinetics; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Membranes | 1984 |
Arginine-vasopressin enhances the responses of lateral septal neurons in the rat to excitatory amino acids and fimbria-fornix stimuli.
Topics: Amino Acids; Animals; Arginine Vasopressin; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Muscimol; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Synapses | 1984 |
Effects of intranigral injections of dopamine agonists and antagonists, glycine, muscimol and N-methyl-D,L-aspartate on locomotor activity.
Topics: Amphetamine; Animals; Antipsychotic Agents; Aspartic Acid; Brain Mapping; Dopamine; Glycine; Male; Motor Activity; Muscimol; N-Methylaspartate; Rats; Rats, Inbred Strains; Substantia Nigra | 1984 |
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid.
Topics: Acetylcholine; Animals; Aspartic Acid; Cerebral Cortex; Convulsants; Drug Interactions; Kynurenic Acid; Kynurenine; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Niacinamide; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats | 1982 |
Actions of excitatory amino acids and kynurenic acid in the primate hippocampus: a preliminary study.
Topics: Amino Acids; Animals; Aspartic Acid; Callitrichinae; Hippocampus; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Oxadiazoles; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid | 1984 |
N-methyl-C-aspartate-type receptors mediate striatal 3H-acetylcholine release evoked by excitatory amino acids.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Corpus Striatum; In Vitro Techniques; Kinetics; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1982 |
Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors.
Topics: 2-Aminoadipic Acid; Animals; Aspartic Acid; Calcium; Cerebellum; Corpus Striatum; Cyclic GMP; Glutamates; Hippocampus; Kainic Acid; Male; Mice; N-Methylaspartate; Pyrrolidines; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter | 1982 |
Activation of NMDA-receptors elicits "fictive locomotion" in lamprey spinal cord in vitro.
Topics: Animals; Aspartic Acid; Glutamates; Lampreys; N-Methylaspartate; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stereoisomerism | 1981 |
Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Kainic Acid; Male; Mice; N-Methylaspartate; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Seizures | 1982 |
Quisqualic acid excitation of cortical neurones is selectively antagonized by streptomycin.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Evoked Potentials; Kainic Acid; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Streptomycin; Synaptic Transmission | 1983 |
Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system.
Topics: Animals; Aspartic Acid; Central Nervous System; Evoked Potentials; Glutamates; Male; N-Methylaspartate; Oxadiazoles; Pyridines; Pyrrolidinones; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1983 |
Effects of excitatory amino acids and their antagonists on membrane and action potentials of cat caudate neurones.
Topics: 2-Aminoadipic Acid; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cats; Caudate Nucleus; Female; Glutamates; Male; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Pipecolic Acids; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1983 |
Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord.
Topics: Amino Acids; Animals; Aspartic Acid; Depression, Chemical; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Organ Specificity; Rats; Rats, Inbred Strains; Spinal Cord; Synapses; Synaptic Transmission | 1983 |
The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate.
Topics: Acetylcholine; Animals; Aspartic Acid; Cats; Female; In Vitro Techniques; Ketamine; Male; N-Methylaspartate; Neurons; Phencyclidine; Rats; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synapses | 1983 |
In vivo release of [3H]-purines by quinolinic acid and related compounds.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Kynurenic Acid; Male; N-Methylaspartate; Purines; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Tritium | 1983 |
Excitatory amino acid receptors in Xenopus embryo spinal cord and their role in the activation of swimming.
Topics: Animals; Aspartic Acid; Kainic Acid; Manganese; Membrane Potentials; Motor Activity; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Swimming; Xenopus | 1984 |
Inhibition by N-acetyl-aspartate of aspartate binding to a proteolipid fraction from rat cerebral cortex.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Male; N-Methylaspartate; Protein Binding; Proteolipids; Rats; Rats, Inbred Strains | 1984 |
Adaptation kinetics in bacterial chemotaxis.
Topics: Aspartic Acid; Chemotaxis; Escherichia coli; Kinetics; Mathematics; N-Methylaspartate | 1983 |
Multiple actions of N-methyl-D-aspartate on cat neocortical neurons in vitro.
Topics: Animals; Aspartic Acid; Cats; Cerebral Cortex; Electric Conductivity; In Vitro Techniques; Kinetics; Membrane Potentials; N-Methylaspartate; Neurons; Tetrodotoxin | 1983 |
On the interaction of 2-amino-7-phosphono-heptanoic acid and quinolinic acid in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Electrophysiology; Iontophoresis; Male; Mice; N-Methylaspartate; Neurons; Pyridines; Quinolinic Acids; Seizures | 1983 |
Selective tryptic cleavage of native cytoplasmic aspartate transaminase holoenzyme.
Topics: Amino Acid Sequence; Animals; Aspartate Aminotransferases; Aspartic Acid; Calorimetry, Differential Scanning; Chromatography, High Pressure Liquid; Cytoplasm; Isoenzymes; Myocardium; N-Methylaspartate; Swine; Trypsin | 1984 |
Antagonism of the hypermotility response induced by excitatory amino acids in the rat nucleus accumbens.
Topics: 2-Aminoadipic Acid; Amino Acids; Animals; Aspartic Acid; Diaminopimelic Acid; Glutamates; Injections; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Septal Nuclei | 1984 |
Magnesium selectively inhibits N-methyl-aspartic acid-induced hypermotility after intra-accumbens injection.
Topics: Animals; Aspartic Acid; Calcium Chloride; Injections; Kainic Acid; Magnesium; Male; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1984 |
Stereoselective effects of two phencyclidine derivatives on N-methylaspartate excitation of spinal neurones in the cat and rat.
Topics: Action Potentials; Animals; Aspartic Acid; Cats; Injections, Intravenous; N-Methylaspartate; Phencyclidine; Rats; Spinal Nerves; Stereoisomerism | 1983 |
Anticonvulsant actions of DS 103-282. Pharmacological studies in rodents and the baboon, Papio papio.
Topics: Acoustic Stimulation; Administration, Oral; Animals; Anticonvulsants; Aspartic Acid; Clonidine; Electroencephalography; Female; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Papio; Photic Stimulation; Species Specificity | 1984 |
Differential sensitivity of rat cerebellar cells in vitro to the neurotoxic effects of excitatory amino acid analogues.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebellum; In Vitro Techniques; Interneurons; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats | 1984 |
Mg2+ dependence of membrane resistance increases evoked by NMDA in hippocampal neurones.
Topics: Animals; Aspartic Acid; Cell Membrane; Evoked Potentials; Hippocampus; In Vitro Techniques; Magnesium; Membrane Potentials; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Pyramidal Tracts; Quisqualic Acid; Rats | 1984 |
The dissociation of evoked release of [3H]-GABA and of endogenous GABA from chick retina in vitro.
Topics: Animals; Aspartic Acid; Chickens; gamma-Aminobutyric Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Perfusion; Potassium Chloride; Retina; Tritium | 1984 |
Structure-activity relations of dipeptide antagonists of excitatory amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Chemical Phenomena; Chemistry; Dipeptides; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana pipiens; Rana temporaria; Spinal Cord; Structure-Activity Relationship | 1984 |
A role for taurine in the maintenance of homeostasis in the central nervous system during hyperexcitation?
Topics: Animals; Aspartic Acid; Calcium; Cell Membrane Permeability; Hippocampus; Homeostasis; N-Methylaspartate; Rabbits; Taurine | 1984 |
Action of L-aspartic, methyl aspartic and acetyl aspartic acids on GABA transaminase histochemical activity in nervous tissue.
Topics: 4-Aminobutyrate Transaminase; Animals; Aspartic Acid; Brain; N-Methylaspartate; NAD; NADP; Rats; Rats, Inbred Strains | 1984 |
Actions of TRH and cyclo-(His-Pro) on spontaneous and evoked activity of cortical neurones.
Topics: Acetylcholine; Animals; Aspartic Acid; Cerebral Cortex; Male; N-Methylaspartate; Neurons; Oxadiazoles; Peptides, Cyclic; Piperazines; Quisqualic Acid; Rats; Thyrotropin-Releasing Hormone | 1983 |
Hypothalamic-pituitary function in adult rats treated neonatally with monosodium glutamate.
Topics: Animals; Animals, Newborn; Aspartic Acid; Castration; Glutamates; Gonadotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; N-Methylaspartate; Naloxone; Rats; Sodium Glutamate | 1982 |
Effect of glutamate, aspartate and related derivatives on cerebellar purkinje cell dendrites in the rat: an in vitro study.
Topics: 2-Aminoadipic Acid; Action Potentials; Animals; Aspartic Acid; Dendrites; Glutamates; In Vitro Techniques; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains | 1982 |
Isomers of 2-amino-7-phosphonoheptanoic acid as antagonists of neuronal excitants.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Hippocampus; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Rats | 1982 |
Acute motor effects of N-methyl-D-aspartic acid and kainic acid applied focally to mesencephalic dopamine cell body regions in the rat.
Topics: Animals; Aspartic Acid; Dopamine; Female; Fluphenazine; Kainic Acid; Mesencephalon; Motor Activity; N-Methylaspartate; Pyrrolidines; Rats; Rats, Inbred Strains; Substantia Nigra | 1980 |
Acute effects of N-methyl-DL-aspartate on the release of pituitary gonadotropins and prolactin in the adult female rhesus monkey.
Topics: Animals; Aspartic Acid; Female; Follicle Stimulating Hormone; Luteinizing Hormone; Macaca mulatta; N-Methylaspartate; Prolactin; Thyrotropin | 1982 |
Behavioural and biochemical studies in rats with N-methyl-D-aspartic acid and kainic acid [proceedings].
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain Chemistry; Kainic Acid; N-Methylaspartate; Pyrrolidines; Rats | 1980 |
Analysis of the fermentation pathways of clostridia using double labelled glutamade.
Topics: Aspartic Acid; Butyrates; Clostridium; Clostridium tetani; Fermentation; Glutamates; Glutarates; Hydroxy Acids; N-Methylaspartate; NADH, NADPH Oxidoreductases; Species Specificity | 1980 |
Antagonism of excitatory amino acid-induced and synaptic excitation of spinal neurones by cis-2,3-piperidine dicarboxylate.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cats; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Rana temporaria; Rats; Spinal Cord; Synapses | 1981 |
Uptake and release of N-methyl-D-aspartate by rat brain slices.
Topics: Animals; Aspartic Acid; Biological Transport; Brain; In Vitro Techniques; Kinetics; N-Methylaspartate; Potassium; Rats; Sodium; Temperature | 1981 |
Two conductance mechanisms activated by applications of L-glutamic, L-aspartic, DL-homocysteic, N-methyl-D-aspartic, and DL-kainic acids to cultured mammalian central neurones.
Topics: Animals; Aspartic Acid; Cells, Cultured; Central Nervous System; Female; Glutamates; Homocysteine; In Vitro Techniques; Kainic Acid; Magnesium; Mice; N-Methylaspartate; Neural Conduction; Neurons | 1980 |
Reorientations of coenzyme in aspartate transaminase studied on single crystals of the enzyme by polarized-light spectrophotometry.
Topics: Acetates; Animals; Aspartate Aminotransferases; Aspartic Acid; Chemical Phenomena; Chemistry, Physical; Chickens; Coenzymes; Crystallization; Dicarboxylic Acids; Myocardium; N-Methylaspartate; Polarography; Pyridoxal Phosphate | 1981 |
N-Methyl-D-aspartate acid: a convulsant with weak neurotoxic properties.
Topics: Animals; Aspartic Acid; Convulsants; Corpus Striatum; Hippocampus; Kainic Acid; N-Methylaspartate; Neurotoxins; Rats | 1981 |
The possible involvement of aspartate receptors in central thermoregulation in the sheep.
Topics: Animals; Aspartic Acid; Body Temperature Regulation; Carbachol; Diaminopimelic Acid; Injections, Intraventricular; Male; N-Methylaspartate; Pyrogens; Receptors, Drug; Serotonin; Sheep | 1981 |
Effects of phencyclidine on excitatory amino acid activation of spinal interneurones in the cat.
Topics: Amino Acids; Animals; Aspartic Acid; Cats; Drug Interactions; Interneurons; N-Methylaspartate; Phencyclidine; Spinal Cord | 1982 |
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations.
Topics: Amino Acids; Animals; Anura; Aspartic Acid; Electric Stimulation; Evoked Potentials; Ganglia, Sympathetic; In Vitro Techniques; N-Methylaspartate; Rats; Spinal Cord; Stereoisomerism | 1982 |
An evaluation of gamma-glutamyl dipeptide derivatives as antagonists of amino acid-induced Na+ fluxes in rat striatum slices.
Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dipeptides; Glutamine; Kainic Acid; N-Methylaspartate; Rats; Sodium | 1982 |
Methyltetrahydrofolate as an antagonist of excitatory amino acids on spinal neurones.
Topics: Amino Acids; Animals; Aspartic Acid; Folic Acid; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Spinal Cord; Tetrahydrofolates | 1982 |
Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine.
Topics: Acetylcholine; Action Potentials; Animals; Aspartic Acid; Cats; Ketamine; N-Methylaspartate; Neurons; Rats; Spinal Cord; Stereoisomerism | 1982 |
Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Brain; Brain Injuries; Cerebral Cortex; Glutamates; Glutamic Acid; Glutamine; Male; Microdialysis; Microinjections; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Serine | 1993 |
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine Maleate; Glioma; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Ion Channels; Kainic Acid; Kinetics; Magnesium Chloride; N-Methylaspartate; Neurotoxins; Pyrrolidinones; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Signal Transduction; Tumor Cells, Cultured | 1994 |
Roles for nitric oxide as an intra- and interneuronal messenger at NMDA release-regulating receptors: evidence from studies of the NMDA-evoked release of [3H]noradrenaline and D-[3H]aspartate from rat hippocampal slices.
Topics: Amino Acid Oxidoreductases; Animals; Aspartic Acid; Calmodulin; Hippocampus; Male; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Tetrodotoxin | 1995 |
[Psychopharmacological properties of three magnesium salts: pidolate, lactate and aspartate].
Topics: Animals; Aspartic Acid; Lactates; Magnesium; Male; Mice; Motor Activity; N-Methylaspartate; Psychopharmacology; Pyrrolidonecarboxylic Acid; Sleep | 1995 |
NMDA-induced glutamate and aspartate release from rat cortical pyramidal neurones: evidence for modulation by a 5-HT1A antagonist.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Drug Synergism; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Molecular Probes; N-Methylaspartate; Piperazines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists | 1995 |
Both electrolytic and excitotoxic lesions of nucleus accumbens disrupt latent inhibition of learning in rats.
Topics: Animals; Aspartic Acid; Behavior, Animal; Conditioning, Psychological; Discrimination Learning; Drinking Behavior; Electric Stimulation; Inhibition, Psychological; Male; N-Methylaspartate; Nucleus Accumbens; Rats; Rats, Wistar; Time Factors | 1995 |
Effects of D-amphetamine administration on the release of endogenous excitatory amino acids in the rat nucleus accumbens.
Topics: Amphetamine; Animals; Aspartic Acid; Excitatory Amino Acids; Glutamic Acid; Haloperidol; Injections, Intravenous; Male; N-Methylaspartate; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1995 |
Pb2+ reduces voltage- and N-methyl-D-aspartate (NMDA)-activated calcium channel currents.
Topics: Animals; Animals, Newborn; Aspartic Acid; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dose-Response Relationship, Drug; Ganglia, Spinal; Glycine; Kinetics; Lead; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Time Factors | 1994 |
Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Aspartic Acid; Blood Pressure; Corpus Striatum; Glutamates; Glutamic Acid; Ischemic Attack, Transient; Kinetics; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Potassium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Aspartate and glutamate mediate excitatory synaptic transmission in area CA1 of the hippocampus.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Calcium; Evoked Potentials; Glucose; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons; Pipecolic Acids; Pyramidal Tracts; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Tritium | 1993 |
Excitatory amino acid-induced phosphoinositide hydrolysis in Müller glia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Chickens; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; Kainic Acid; N-Methylaspartate; Neuroglia; Quinoxalines; Quisqualic Acid; Receptors, Amino Acid; Retina; Tritium | 1993 |
Heterocarrier-mediated reciprocal modulation of glutamate and glycine release in rat cerebral cortex and spinal cord synaptosomes.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium; Spinal Cord; Synaptosomes | 1994 |
The effect of L-glutamate on the afferent resting activity in the cephalopod statocyst.
Topics: Action Potentials; Afferent Pathways; Animals; Aspartic Acid; Decapodiformes; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Mollusca; N-Methylaspartate; Nerve Fibers; Octopodiformes; Postural Balance; Quisqualic Acid; Species Specificity | 1994 |
A subtype of the metabotropic glutamate receptor family in the olfactory system of Atlantic salmon.
Topics: Animals; Aspartic Acid; Blotting, Northern; Brain; Cell Membrane; DNA Probes; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kainic Acid; N-Methylaspartate; Nucleic Acid Hybridization; Olfactory Mucosa; Rats; Receptors, Metabotropic Glutamate; Salmon; Taurocholic Acid; Type C Phospholipases | 1994 |
L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a.
Topics: Alanine Transaminase; Animals; Asparagine; Aspartic Acid; Cell Line; Cell Membrane; Cricetinae; Cycloleucine; Cysteine; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamate Decarboxylase; Glutamic Acid; Hydrolysis; Kidney; N-Methylaspartate; Phosphatidylinositols; Pyrrolidines; Receptors, Metabotropic Glutamate | 1994 |
N-acetylaspartylglutamate selectively inhibits neuronal responses to N-methyl-D-aspartic acid in vitro.
Topics: Animals; Aspartic Acid; Canavan Disease; Cell Survival; Cells, Cultured; Cerebellum; Culture Media; Dipeptides; Kainic Acid; Mice; Mice, Inbred BALB C; N-Methylaspartate; Neurons | 1994 |
Regulation of D-aspartate release by glutamate and GABA receptors in cerebral cortical slices from developing and ageing mice.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Quisqualic Acid; Receptors, GABA; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Taurine | 1994 |
N-methyl-D-aspartate releases gamma-aminobutyric acid from rat striatum in vivo: a microdialysis study using a novel preloading method.
Topics: Animals; Aspartic Acid; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Infusions, Parenteral; Kinetics; Male; N-Methylaspartate; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Tritium | 1993 |
An experimental arthritis model in rats: the effects of NMDA and non-NMDA antagonists on aspartate and glutamate release in the dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Arthritis; Aspartic Acid; Carrageenan; Glutamates; Glutamic Acid; Injections, Intra-Articular; Kaolin; Knee Joint; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Spinal Cord | 1993 |
The monosialoganglioside GM1 dose-dependently reduces regional cerebral metabolic rates for glucose in awake rats.
Topics: Animals; Aspartic Acid; Binding, Competitive; Brain; Dose-Response Relationship, Drug; G(M1) Ganglioside; Glucose; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred F344 | 1993 |
Histamine potentiates N-methyl-D-aspartate responses in acutely isolated hippocampal neurons.
Topics: Animals; Aspartic Acid; Binding Sites; Calcium; Cell Separation; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Glycine; Hippocampus; Histamine; N-Methylaspartate; Neurons; Osmolar Concentration; Receptors, Histamine; Time Factors | 1993 |
Regulation by the neuropeptide cholecystokinin (CCK-8S) of protein phosphorylation in the neostriatum.
Topics: Animals; Aspartic Acid; Dopamine and cAMP-Regulated Phosphoprotein 32; Glutamates; Male; N-Methylaspartate; Neostriatum; Nerve Tissue Proteins; Neuropeptides; Phosphoproteins; Rats; Rats, Sprague-Dawley; Sincalide | 1993 |
Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats.
Topics: Animals; Arginine; Aspartic Acid; Enzyme Inhibitors; Excitatory Amino Acids; Glutamic Acid; Hippocampus; Male; Microdialysis; Motor Activity; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1995 |
The effects of N-methyl-D,L-aspartic acid and aspartic acid on the plasma concentration of gonadotrophins, GH and prolactin in the ewe.
Topics: Animals; Aspartic Acid; Excitatory Amino Acid Agonists; Female; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Growth Hormone; Luteinizing Hormone; N-Methylaspartate; Neurotransmitter Agents; Ovulation; Prolactin; Secretory Rate; Sheep | 1996 |
Selective activation of calcium permeability by aspartate in Purkinje cells.
Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Homocysteine; Magnesium; Mice; Mice, Knockout; N-Methylaspartate; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Permeability; Purkinje Cells; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate | 1996 |
Histamine and NMDA-receptors in the hippocampus: polyamines and intracellular binding site.
Topics: Animals; Aspartic Acid; Binding Sites; Hippocampus; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; N-Methylaspartate; Patch-Clamp Techniques; Phosphatidylethanolamines; Platelet Aggregation Inhibitors; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3; Receptors, N-Methyl-D-Aspartate | 1996 |
L-Glutamate-induced responses in OFF-type bipolar cells of the cat retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Calcium; Cats; Chlorides; Cycloleucine; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; In Vitro Techniques; Ion Transport; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium; Retina; Retinal Cone Photoreceptor Cells; Sodium | 1996 |
Origin of aspartate-induced responses in rat cerebellar Purkinje cells.
Topics: Animals; Aspartic Acid; Glutamic Acid; Interneurons; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, N-Methyl-D-Aspartate | 1996 |
Pharmacology of N-methyl-D-aspartate-evoked [3H]noradrenaline release in adult rat spinal cord.
Topics: Animals; Aspartic Acid; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tritium | 1996 |
An abnormal ketamine response in mutants defective in the ryanodine receptor gene ryr-1 (unc-68) of Caenorhabditis elegans.
Topics: Amino Acid Sequence; Anesthetics, Dissociative; Animals; Animals, Genetically Modified; Aspartic Acid; Caenorhabditis elegans; Calcium Channels; Cloning, Molecular; Gene Expression; Genes, Helminth; Ketamine; Molecular Sequence Data; Muscle Contraction; Muscle Proteins; Mutation; N-Methylaspartate; Organ Specificity; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Ryanodine Receptor Calcium Release Channel; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 1997 |
Glutamate receptor agonists evoked Ca(2+)-dependent and Ca(2+)-independent release of [3H]D-aspartate from cultured chick retina cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Calcium; Cells, Cultured; Chickens; Excitatory Amino Acid Agonists; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Potassium Chloride; Receptors, Glutamate; Retina; Tritium | 1996 |
Protective effects of neurosteroids against NMDA-induced seizures and lethality in mice.
Topics: Animals; Anticonvulsants; Aspartic Acid; Hippocampus; In Vitro Techniques; Lethal Dose 50; Male; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Seizures; Steroids | 1998 |
Aspartate as a selective NMDA receptor agonist in cultured cells from the avian retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Retina | 1998 |
Excitatory amino acids and serotonin uptake blockers reveal two physiologically distinct serotonin systems in the retina of the skate, Raja erinacea.
Topics: Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Fluoxetine; Monoamine Oxidase Inhibitors; N-Methylaspartate; Organ Culture Techniques; Pargyline; Potassium; Retina; Selective Serotonin Reuptake Inhibitors; Serotonin; Skates, Fish; Zimeldine | 1998 |
Gain control of NMDA-receptor currents by intracellular sodium.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Electrophysiology; Excitatory Postsynaptic Potentials; Hippocampus; Ionophores; Monensin; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phosphorylation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium; Sodium Channels; Spine; src-Family Kinases; Synaptic Transmission | 1998 |
Effects of competitive NMDA receptor antagonists on excitatory amino acid-evoked currents in mouse spinal cord neurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding, Competitive; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
The effects of excitatory amino acids on isolated gut segments of the rat.
Topics: Animals; Aspartic Acid; Cycloleucine; Digestive System; Digestive System Physiological Phenomena; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Female; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; N-Methylaspartate; Neuroprotective Agents; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Role of intracellular Ca(2+) stores shaping normal activity in brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Calcium; Dantrolene; Hippocampus; Injections, Intraventricular; Male; Microdialysis; N-Methylaspartate; Radioligand Assay; Rats; Rats, Wistar; Reference Values; Spectrometry, Fluorescence | 1999 |
The taste of monosodium glutamate (MSG), L-aspartic acid, and N-methyl-D-aspartate (NMDA) in rats: are NMDA receptors involved in MSG taste?
Topics: Animals; Aspartic Acid; Avoidance Learning; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Glutamate; Taste | 1999 |
Substrate turnover by transporters curtails synaptic glutamate transients.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Benzothiadiazines; Cells, Cultured; Evoked Potentials; Glutamic Acid; Hippocampus; Membrane Potentials; N-Methylaspartate; Neuroglia; Neurons; Oocytes; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission; Xenopus laevis | 1999 |
The ontogeny of glutamate receptors and D-aspartate binding sites in the ovine CNS.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Embryonic and Fetal Development; Fetus; Glutamic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Sheep | 1999 |
Control of synaptic depression by glutamate transporters.
Topics: Action Potentials; Alanine Transaminase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Anti-Bacterial Agents; Antihypertensive Agents; Aspartic Acid; ATP-Binding Cassette Transporters; Benzothiadiazines; Chick Embryo; Cochlear Nucleus; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neural Inhibition; Neuronal Plasticity; Receptors, AMPA; Synaptic Transmission | 2000 |
Occurrence of D-aspartic acid and N-methyl-D-aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release.
Topics: Animals; Aspartic Acid; Circadian Rhythm; Gonadotropin-Releasing Hormone; Growth Hormone; Hypothalamus; In Vitro Techniques; Luteinizing Hormone; Male; N-Methylaspartate; Neurosecretory Systems; Pituitary Gland, Anterior; Rats; Rats, Wistar; Tissue Distribution | 2000 |
Acute decrease in net glutamate uptake during energy deprivation.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Brain Ischemia; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kinetics; Membrane Potentials; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Organ Culture Techniques; Patch-Clamp Techniques; Pyrrolidines; Quinoxalines; Rats | 2000 |
Glutamate-mediated neuroprotection against N-methyl-D-aspartate toxicity: a role for metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cell Death; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Neuroprotective Agents; Oligodeoxyribonucleotides, Antisense; Organ Culture Techniques; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Tetrodotoxin | 2000 |
The role of D-aspartic acid and N-methyl-D-aspartic acid in the regulation of prolactin release.
Topics: Animals; Aspartic Acid; Excitatory Amino Acid Agonists; Hippocampus; Hypothalamus; Male; N-Methylaspartate; Pituitary Gland; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Wistar | 2000 |
Altered striatal amino acid neurotransmitter release monitored using microdialysis in R6/1 Huntington transgenic mice.
Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; gamma-Aminobutyric Acid; Glutamic Acid; Huntington Disease; Mice; Mice, Transgenic; Microdialysis; N-Methylaspartate; Neurotransmitter Agents; Potassium Chloride | 2001 |
N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid, the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; HIV Envelope Protein gp120; Hydrogen-Ion Concentration; Male; N-Methylaspartate; Norepinephrine; Piperidines; Protein Kinase C; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Synaptosomes; Zinc | 2001 |
Characterization of the glutamatergic system for induction and maintenance of allodynia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; ATP-Binding Cassette Transporters; Capsaicin; Dinoprost; Dinoprostone; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Pain; Pain Measurement; Physical Stimulation; Posterior Horn Cells; Receptors, Glutamate; Synapses; Synaptic Transmission; Touch | 2001 |
Pituitary hormone and insulin responses to infusion of amino acids and N-methyl-D,L-aspartate in horses.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Female; Glutamic Acid; Growth Hormone; Horses; Insulin; Lysine; Male; N-Methylaspartate; Pituitary Hormones; Prolactin; Radioimmunoassay; Thyrotropin | 2001 |
The effect of N-acetyl-L-aspartic acid dilithium salt on dopamine release and synthesis in the rat striatum in vivo.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Male; N-Methylaspartate; Rats; Rats, Wistar; Time Factors | 2001 |
Vasorelaxation induced by L-glutamate in porcine coronary arteries.
Topics: Animals; Aspartic Acid; Coronary Vessels; Drug Interactions; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Histamine; N-Methylaspartate; Potassium; Swine; Vasodilation | 2001 |
Glomerulus-specific synchronization of mitral cells in the olfactory bulb.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kinetics; N-Methylaspartate; Olfactory Bulb; Olfactory Receptor Neurons; Periodicity; Quinoxalines; Rats; Rats, Sprague-Dawley; Smell | 2001 |
N-acetylaspartylglutamate (NAAG) is the probable mediator of axon-to-glia signaling in the crayfish medial giant nerve fiber.
Topics: Animals; Aspartic Acid; Astacoidea; Axons; Carboxypeptidases; Cell Communication; Cysteic Acid; Dipeptides; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate Carboxypeptidase II; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Nervous System; Neuroglia; Organophosphorus Compounds; Receptors, Glutamate; Signal Transduction; Time Factors | 2001 |
Occurrence of N-methyl-L-aspartate in bivalves and its distribution compared with that of N-methyl-D-aspartate and D,L-aspartate.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Thin Layer; Mollusca; N-Methylaspartate; Species Specificity; Time Factors; Tissue Distribution | 2001 |
GABA release induced by aspartate-mediated activation of NMDA receptors is modulated by dopamine in a selective subpopulation of amacrine cells.
Topics: Amacrine Cells; Animals; Aspartic Acid; Carrier Proteins; Cell Survival; Chickens; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Immunohistochemistry; Isoenzymes; Kainic Acid; L-Lactate Dehydrogenase; Membrane Proteins; Membrane Transport Proteins; N-Methylaspartate; Organic Anion Transporters; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2001 |
Effects of metabotropic glutamate receptor agonists and antagonists on D-aspartate release from mouse cerebral cortical and striatal slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; N-Methylaspartate; Receptors, Metabotropic Glutamate; Tritium | 2001 |
A comparison of some metabolic effects of N-methylaspartate stereoisomers, glutamate and depolarization: a multinuclear MRS study.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Dizocilpine Maleate; Electrophysiology; Energy Metabolism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Lactic Acid; Magnetic Resonance Spectroscopy; N-Methylaspartate; Osmolar Concentration; Phosphocreatine; Stereoisomerism | 2002 |
Effects of bilobalide on amino acid release and electrophysiology of cortical slices.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Cyclopentanes; Diterpenes; Electrophysiology; Furans; Ginkgolides; Glutamic Acid; In Vitro Techniques; Magnesium; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; N-Methylaspartate; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Oximes; Potassium; Veratridine | 2002 |
In vivo temporal sequence of rat striatal glutamate, aspartate and dopamine efflux during apomorphine, nomifensine, NMDA and PDC in situ administration.
Topics: Animals; Apomorphine; Aspartic Acid; Dicarboxylic Acids; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Electrodes, Implanted; Electrophoresis, Capillary; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Neostriatum; Neurotransmitter Uptake Inhibitors; Nomifensine; Online Systems; Pyrrolidines; Rats; Rats, Sprague-Dawley | 2002 |
L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus.
Topics: Animals; Arginase; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Argininosuccinic Acid; Aspartic Acid; Citrulline; Dinoprost; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Glutamic Acid; Glutamine; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Thiolester Hydrolases; Ubiquitin Thiolesterase | 2002 |
Conformational change in aspartate aminotransferase on substrate binding induces strain in the catalytic group and enhances catalysis.
Topics: Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Catalysis; Escherichia coli; Glycine; Hydrogen-Ion Concentration; Kinetics; Ligands; Lysine; Malates; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; N-Methylaspartate; Oxygen; Photons; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Spectrophotometry; Tyrosine; Valine | 2003 |
Glutamate and aspartate do not exhibit the same changes in their extracellular concentrations in the rat striatum after N-methyl-D-aspartate local administration.
Topics: Animals; Aspartic Acid; Corpus Striatum; Extracellular Space; Glutamic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Involvement of acetylated tubulin in the regulation of Na+,K+ -ATPase activity in cultured astrocytes.
Topics: Acetylation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Ionophores; Mice; Monensin; N-Methylaspartate; Sodium-Potassium-Exchanging ATPase; Tubulin | 2003 |
Modulation of glutamatergic transmission by bergmann glial cells in rat cerebellum in situ.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Cell Communication; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Neuroglia; Patch-Clamp Techniques; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Sodium; Synaptic Transmission | 2003 |
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis.
Topics: Animals; Aspartic Acid; Axons; Benzoxazines; Cannabinoids; Cyclohexanols; Dizocilpine Maleate; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino Acid Agonists; Gene Deletion; Humans; Mice; Mice, Transgenic; Monomeric GTP-Binding Proteins; Morpholines; Multiple Sclerosis; N-Methylaspartate; Naphthalenes; Nerve Degeneration; Nuclear Proteins; Receptors, Cannabinoid; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Retina; Saccharomyces cerevisiae Proteins; Spinal Cord; Uveitis | 2003 |
THE EXCITATION AND DEPRESSION OF MAMMALIAN CORTICAL NEURONES BY AMINO ACIDS.
Topics: Acetates; Amino Acids; Aminocaproates; Aminocaproic Acid; Animals; Aspartic Acid; Butyrates; Caprylates; Cats; Central Nervous System; Cerebral Cortex; Glutamic Acid; Hydroxybutyrates; N-Methylaspartate; Neurons; Pharmacology; Propionates; Research; Spinal Cord; Sulfonic Acids; Taurine | 1964 |
Beta-amyloid prevents excitotoxicity via recruitment of glial glutamate transporters.
Topics: Amino Acid Transport System X-AG; Amyloid beta-Peptides; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Colorimetry; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Peptide Fragments; Rats; Rats, Wistar | 2003 |
Occurrence and neuroendocrine role of D-aspartic acid and N-methyl-D-aspartic acid in Ciona intestinalis.
Topics: Animals; Aspartic Acid; Ciona intestinalis; Female; Gonadotropin-Releasing Hormone; Gonads; In Vitro Techniques; Invertebrate Hormones; Male; N-Methylaspartate; Neurosecretory Systems; Progesterone; Reproduction; Stereoisomerism; Testosterone | 2003 |
Local differences in GABA release induced by excitatory amino acids during retina development: selective activation of NMDA receptors by aspartate in the inner retina.
Topics: Animals; Aspartic Acid; Carrier Proteins; Chick Embryo; Excitatory Amino Acids; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Immunohistochemistry; In Vitro Techniques; Kainic Acid; Membrane Proteins; Membrane Transport Proteins; N-Methylaspartate; Organic Anion Transporters; Receptors, N-Methyl-D-Aspartate; Retina; Zygote | 2003 |
Glutamate transporters prevent the generation of seizures in the developing rat neocortex.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Biological Clocks; Calcium Signaling; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Neocortex; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2004 |
Extracellular taurine in the substantia nigra: taurine-glutamate interaction.
Topics: Adrenergic Agents; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Chemistry; Calcium; Chelating Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Excitatory Amino Acid Antagonists; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Ketamine; Male; Membrane Potentials; Microdialysis; N-Methylaspartate; Oxidopamine; Potassium; Rats; Rats, Sprague-Dawley; Substantia Nigra; Taurine; Time Factors; Zinc | 2004 |
Glutamate taste: Discrimination between the tastes of glutamate agonists and monosodium glutamate in rats.
Topics: Amiloride; Aminobutyrates; Animals; Aspartic Acid; Avoidance Learning; Discrimination, Psychological; Excitatory Amino Acid Agonists; Male; N-Methylaspartate; Rats; Sodium Glutamate; Taste; Taste Threshold | 2004 |
Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density.
Topics: 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Dizocilpine Maleate; Drug Interactions; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Models, Neurological; N-Methylaspartate; Neural Inhibition; Neurons; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Synapses | 2004 |
Role of N-methyl-D-aspartate receptors in gastric mucosal blood flow induced by histamine.
Topics: Acids; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aspartic Acid; Cimetidine; Drug Interactions; Gastric Mucosa; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Immunohistochemistry; Laser-Doppler Flowmetry; Male; N-Methylaspartate; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Regional Blood Flow; Time Factors; Tripelennamine; Valine; Yohimbine | 2004 |
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
NMDA-receptor mediated efflux of N-acetylaspartate: physiological and/or pathological importance?
Topics: Amino Acids; Animals; Aspartic Acid; Cell Death; Chromatography, High Pressure Liquid; Excitatory Amino Acid Agonists; Glutathione; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Organ Culture Techniques; Potassium; Propidium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spectrophotometry, Ultraviolet | 2004 |
Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Amino Acids; Animals; Aspartic Acid; Dicarboxylic Acids; Drug Interactions; Entorhinal Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission; Xanthenes | 2004 |
Glutamate-evoked alterations of glial and neuronal cell morphology in the guinea pig retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Cell Size; Circadian Rhythm; Cytochalasin D; Cytoskeleton; Dicarboxylic Acids; Dopamine; Eye Proteins; Glutamic Acid; Guinea Pigs; Ischemia; Kainic Acid; N-Methylaspartate; Neuroglia; Neurons; Nocodazole; Potassium; Pyrrolidines; Receptors, AMPA; Receptors, Kainic Acid; Retina; Retinal Ganglion Cells; Synaptic Transmission; Xanthenes | 2004 |
Binding of C5-dicarboxylic substrate to aspartate aminotransferase: implications for the conformational change at the transaldimination step.
Topics: Amines; Amino Acids, Dicarboxylic; Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Escherichia coli Proteins; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Imines; Ligands; Models, Chemical; N-Methylaspartate; Protein Conformation; Substrate Specificity | 2005 |
Functional assessment of glutamate clearance mechanisms in a chronic rat glaucoma model using retinal ganglion cell calcium imaging.
Topics: Animals; Animals, Newborn; Aspartic Acid; Calcium; Cells, Cultured; Diagnostic Imaging; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Fura-2; Glaucoma; Glutamic Acid; In Vitro Techniques; Intraocular Pressure; Male; N-Methylaspartate; Optic Nerve; Rats; Rats, Long-Evans; Retina; Retinal Ganglion Cells; Time Factors | 2005 |
Effects of glutamate transporter and receptor ligands on neuronal glutamate uptake.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ligands; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Oxepins; Rats; Rats, Wistar; Receptors, Glutamate; Tritium; Valine | 2005 |
Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Blotting, Western; Cell Death; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Gene Expression Regulation, Developmental; Glutamic Acid; Heptanes; Heterocyclic Compounds, 3-Ring; Hippocampus; Homeostasis; Humans; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Time Factors; Tritium | 2005 |
Na+ channel-mediated Ca2+ entry leads to glutamate secretion in mouse neocortical preplate.
Topics: Animals; Aspartic Acid; Brain; Calcium; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Mice; Mice, Inbred C57BL; Models, Biological; N-Methylaspartate; Neocortex; Neurons; Receptors, AMPA; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sodium; Sodium Channels; Software; Taurine; Time Factors; Veratridine | 2005 |
Changing the specificity of a bacterial chemoreceptor.
Topics: Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Chemoreceptor Cells; Chemotaxis; Culture Media; Cysteic Acid; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Membrane Proteins; Methyl-Accepting Chemotaxis Proteins; Molecular Sequence Data; N-Methylaspartate; Phenylalanine; Receptors, Amino Acid; Receptors, Cell Surface; Sequence Alignment | 2006 |
Kynurenic acid synthesis in bovine retinal slices--effect of glutamate agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cattle; Excitatory Amino Acid Agonists; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Organ Culture Techniques; Retina | 2006 |
NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes.
Topics: Animals; Aspartic Acid; Astrocytes; Cerebral Cortex; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Green Fluorescent Proteins; Humans; Membrane Potentials; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Peptides, Cyclic; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2006 |
Low cerebrospinal fluid glutamate and glycine in refractory affective disorder.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Chromatography, High Pressure Liquid; Depressive Disorder, Major; Drug Resistance; Electroconvulsive Therapy; Female; Glutamic Acid; Glycine; Humans; Male; Middle Aged; N-Methylaspartate; Statistics as Topic | 2007 |
Calpain- and caspase-mediated alphaII-spectrin and tau proteolysis in rat cerebrocortical neuronal cultures after ecstasy or methamphetamine exposure.
Topics: Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Aspartic Acid; Calpain; Caspase Inhibitors; Caspases; Cell Death; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Dipeptides; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Methamphetamine; Microfilament Proteins; Molecular Weight; N-Methyl-3,4-methylenedioxyamphetamine; N-Methylaspartate; Neurons; Peptide Fragments; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; tau Proteins; Time Factors; Vesicular Transport Proteins | 2007 |
+H-proton-magnetic resonance spectroscopic findings in a patient with acute hemicerebellitis presenting without localized signs: a case report.
Topics: Acute Disease; Adolescent; Aspartic Acid; Cerebellar Diseases; Choline; Cranial Fossa, Posterior; Creatine; Female; Humans; Inflammation; Magnetic Resonance Imaging; N-Methylaspartate; Protons | 2006 |
Functional and structural characterization of D-aspartate oxidase from porcine kidney: non-Michaelis kinetics due to substrate activation.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; D-Aspartate Oxidase; Dicarboxylic Acids; Female; Glutamic Acid; Kidney; Kinetics; Molecular Sequence Data; N-Methylaspartate; Oxygen; Sequence Alignment; Sus scrofa | 2007 |
N-acetylaspartate monomethyl ester increases N-acetylaspartate concentration in cultured rat hippocampal slices: effects on excitotoxicity and levels of amino acids and chloride.
Topics: Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Chlorides; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Time Factors | 2007 |
In vitro studies on the putative function of N-acetylaspartate as an osmoregulator.
Topics: Animals; Aspartic Acid; Excitatory Amino Acid Agonists; Hippocampus; N-Methylaspartate; Osmolar Concentration; Potassium; Rats; Rats, Sprague-Dawley; Taurine; Tissue Culture Techniques; Water-Electrolyte Balance | 2007 |
Effect of the L- or D-aspartate on ecto-5'nucleotidase activity and on cellular viability in cultured neurons: participation of the adenosine A(2A) receptors.
Topics: 5'-Nucleotidase; Adenosine Monophosphate; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; D-Aspartic Acid; Glutamic Acid; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptor, Adenosine A2A | 2007 |
N-methyl-D-aspartate autoreceptors respond to low and high agonist concentrations by facilitating, respectively, exocytosis and carrier-mediated release of glutamate in rat hippocampus.
Topics: Animals; Aspartic Acid; Autoreceptors; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exocytosis; Glutamic Acid; Glycine; Hippocampus; HIV Envelope Protein gp120; Male; N-Methylaspartate; Presynaptic Terminals; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Synaptosomes; Vesicular Glutamate Transport Proteins | 2007 |
GMP prevents excitotoxicity mediated by NMDA receptor activation but not by reversal activity of glutamate transporters in rat hippocampal slices.
Topics: Animals; Aspartic Acid; Brain Diseases, Metabolic; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine Monophosphate; Hippocampus; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Vesicular Glutamate Transport Proteins | 2008 |
Glutamate receptors modulate sodium-dependent and calcium-independent vitamin C bidirectional transport in cultured avian retinal cells.
Topics: Animals; Animals, Newborn; Ascorbic Acid; Aspartic Acid; Biological Transport; Calcium; Chelating Agents; Chick Embryo; Cytoskeletal Proteins; Egtazic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Neurons; Organic Anion Transporters, Sodium-Dependent; Rats; Receptors, Glutamate; Retina; Sodium; Sodium-Coupled Vitamin C Transporters; Symporters; Tissue Culture Techniques; Tritium | 2009 |
Experimental glutamatergic excitotoxicity in rabbit retinal ganglion cells: block by memantine.
Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Electroretinography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Memantine; N-Methylaspartate; Photic Stimulation; Rabbits; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells | 2009 |
Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels.
Topics: Animals; Antimetabolites; Aspartic Acid; Calcium; Calcium Signaling; Cells, Cultured; Cerebellum; Cytosol; Deoxyglucose; Excitatory Amino Acid Agonists; Glucose; Lactic Acid; Malates; Mice; N-Methylaspartate; Neurons; Neurotransmitter Agents; Synaptic Transmission | 2009 |
Synaptic and extrasynaptic factors governing glutamatergic retinal waves.
Topics: Amino Acid Transport Systems, Acidic; Animals; Animals, Newborn; Aspartic Acid; Calcium; Dihydro-beta-Erythroidine; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; N-Methylaspartate; Neural Inhibition; Nicotinic Antagonists; Patch-Clamp Techniques; Pyridazines; Quinoxalines; Retinal Ganglion Cells; Synapses; Synaptic Transmission; Time Factors; Valine; Vesicular Glutamate Transport Protein 1 | 2009 |
How can an inert gas counterbalance a NMDA-induced glutamate release?
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Asparagine; Aspartic Acid; Catheters, Indwelling; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Glutamine; Homovanillic Acid; Inert Gas Narcosis; Male; Microdialysis; N-Methylaspartate; Nitrogen; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Statistics, Nonparametric | 2009 |
Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions.
Topics: Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Immunoprecipitation; Magnesium; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tetrahydronaphthalenes; Tritium | 2011 |
Glutamate spillover promotes the generation of NMDA spikes.
Topics: Action Potentials; Animals; Animals, Newborn; Aspartic Acid; Biophysics; Calcium; Calcium Channel Blockers; Calcium Signaling; Chelating Agents; Dendrites; Drug Synergism; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; In Vitro Techniques; Indoles; Male; Mice; N-Methylaspartate; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Quinoxalines; Statistics, Nonparametric | 2011 |
Sex difference in stress-induced enhancement of hippocampal CA1 long-term depression during puberty.
Topics: Adrenalectomy; Androgens; Animals; Animals, Newborn; Aspartic Acid; CA1 Region, Hippocampal; Corticosterone; Dexamethasone; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glucocorticoids; Glutamic Acid; In Vitro Techniques; Long-Term Synaptic Depression; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Ovariectomy; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sex Characteristics; Statistics, Nonparametric; Stress, Psychological; Synaptosomes; Testosterone; Valine | 2012 |
Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Excitatory Amino Acid Antagonists; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA Plasma Membrane Transport Proteins; Gene Knock-In Techniques; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neurons; Pregnanolone; Receptor, Metabotropic Glutamate 5; Receptors, Glutamate; Receptors, Metabotropic Glutamate; RNA, Messenger; Trinucleotide Repeat Expansion | 2012 |
Frequency-dependent Escherichia coli chemotaxis behavior.
Topics: Aspartic Acid; Chemotaxis; Escherichia coli; Microfluidic Analytical Techniques; Models, Biological; N-Methylaspartate | 2012 |
Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein.
Topics: Acetamides; Animals; Aspartic Acid; Calcium; Cell Death; Cell Differentiation; Cell Line, Tumor; Cell Movement; Enzyme Activation; Extracellular Space; HMGB1 Protein; Humans; Male; Mice; N-Methylaspartate; Neurites; Nitric Oxide; Nitric Oxide Synthase Type I; Presynaptic Terminals; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tritium | 2012 |
Decreased levels of D-aspartate and NMDA in the prefrontal cortex and striatum of patients with schizophrenia.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Female; Humans; Male; Middle Aged; N-Methylaspartate; Postmortem Changes; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2013 |
Neuroprotective role of superoxide dismutase 1 in retinal ganglion cells and inner nuclear layer cells against N-methyl-d-aspartate-induced cytotoxicity.
Topics: Amacrine Cells; Animals; Apoptosis; Aspartic Acid; Dark Adaptation; Electroretinography; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique, Indirect; Immunoblotting; In Situ Nick-End Labeling; Intravitreal Injections; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Retinal Bipolar Cells; Retinal Ganglion Cells; Retinal Horizontal Cells; RNA, Messenger; Superoxide Dismutase; Superoxide Dismutase-1 | 2013 |
Aberrant NMDA-dependent LTD after perinatal ethanol exposure in young adult rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Central Nervous System Depressants; Electric Stimulation; Ethanol; Excitatory Amino Acid Agents; Female; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Male; N-Methylaspartate; Patch-Clamp Techniques; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2015 |
Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity.
Topics: Amino Acid Transport System X-AG; Animals; Antineoplastic Agents; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Cytokines; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Glutamic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Oncostatin M; Oncostatin M Receptor beta Subunit; Retroviridae Proteins, Oncogenic; Signal Transduction | 2016 |
Extracellular Glutamate in the Nucleus Accumbens Is Nanomolar in Both Synaptic and Non-synaptic Compartments.
Topics: Animals; Aspartic Acid; Calcium Signaling; Cell Compartmentation; Extracellular Space; Female; Glutamic Acid; Male; N-Methylaspartate; Neurons; Nucleus Accumbens; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses | 2017 |
Quantitative determination of free D-Asp, L-Asp and N-methyl-D-aspartate in mouse brain tissues by chiral separation and Multiple Reaction Monitoring tandem mass spectrometry.
Topics: Animals; Aspartic Acid; Brain; Chromatography, Liquid; Limit of Detection; Mice; N-Methylaspartate; Reference Standards; Reproducibility of Results; Stereoisomerism; Tandem Mass Spectrometry | 2017 |
G protein-coupled receptor 37-like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia.
Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Brain; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation, Developmental; Hippocampus; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; N-Methylaspartate; Neurons; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology | 2018 |
The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization.
Topics: Animals; Aspartic Acid; Astrocytes; Brain Diseases; Cell Size; Computational Biology; Electrophysiological Phenomena; Glutamic Acid; Homeostasis; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Models, Neurological; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Visual Cortex | 2017 |
Mechanisms of NMDA receptor inhibition by diarylamidine compounds.
Topics: Animals; Aspartic Acid; Benzamidines; Cells, Cultured; Hippocampus; N-Methylaspartate; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate | 2020 |
Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Glutamic Acid; Male; Migraine Disorders; N-Methylaspartate; Nociception; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Trigeminal Ganglion | 2022 |