aspartic acid has been researched along with methotrexate in 93 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (45.16) | 18.7374 |
| 1990's | 37 (39.78) | 18.2507 |
| 2000's | 11 (11.83) | 29.6817 |
| 2010's | 3 (3.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Albrecht, AM; Biedler, JL; Spengler, BA | 1 |
| Grey, D; Hamilton-Miller, JM | 1 |
| Biedler, JL; Spengler, BA | 1 |
| Chabner, BA; Eliot, HM; Myers, CE | 1 |
| Donsbach, RC; Sirotnak, FM | 2 |
| Donsback, RC; Sirotnak, FM | 1 |
| Bertino, JR; Chello, PL; DeAngelis, LM; McQueen, CA | 1 |
| Harstrick, A; Köhne-Wömpner, CH; Rustum, YM; Schmoll, HJ | 1 |
| Coit, D; Colofiore, J; Kelsen, D; Martin, DS; Sawyer, R | 1 |
| Davidson, K; Forseth, B; Scott, J; Von Hoff, DD; Waddelow, T; Wahl, G | 1 |
| Bruckner, HW; Motwani, BT | 1 |
| Haran, MS; Kinsella, AR | 1 |
| Hart, IR; Kalebic, T; McMillan, TJ; Stark, GR | 1 |
| Bastos, MT; Campello, AP; Klüppel, ML; Oliveria, MB | 1 |
| Tlsty, TD | 1 |
| Comiskey, SJ; Heath, TD | 1 |
| Martin, DS | 2 |
| Kemeny, NE; Martin, DS; Schneider, A | 1 |
| Colofiore, J; Derby, S; Kemeny, N; Martin, DS; Salvia, B; Sawyer, RC; Schneider, A | 1 |
| Abbondandolo, A; Bonatti, S; Menichini, P; Miele, M; Ottaggio, L | 1 |
| Carl, PL; Goz, B; Tlsty, TD | 1 |
| Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 2 |
| Cillo, C; Hill, RP; Ling, V | 1 |
| Appleman, JR; Blakley, RL; Howell, EE; Kraut, J; Kühl, M | 1 |
| Hoth, DF; King, SA; Leyland-Jones, B; O'Dwyer, PJ | 1 |
| Singh, UC | 1 |
| Fox, M; Kinsella, AR; Szallasi, A | 1 |
| Fox, M; Kinsella, AR | 1 |
| Leyland-Jones, B; O'Dwyer, PJ | 1 |
| Howell, EE; Kraut, J; Oatley, SJ; Villafranca, JE; Warren, MS | 1 |
| Blakley, RL; Howell, EE; Kraut, J; London, RE; Warren, MS | 1 |
| Cillo, C; Dick, JE; Hill, RP; Ling, V | 1 |
| Giulotto, E; Knights, C; Stark, GR | 1 |
| Bodansky, O; Nisselbaum, JS; Schwartz, MK | 1 |
| Maley, F; Maley, GF | 1 |
| Albrecht, AM; Hutchison, DJ | 1 |
| Hutchison, DJ; Rader, JI | 1 |
| Albrecht, AM; Biedler, JL; Hutchison, DJ; Spengler, BA | 1 |
| Bertino, JR; Chabner, BA; McCullough, JL | 1 |
| Goldman, P; Levy, CC | 1 |
| Powis, G | 1 |
| Bedikian, AY | 1 |
| Biedler, JL; Melera, PW; Wolgemuth, DJ | 1 |
| Shapiro, WR; Young, DF | 1 |
| Bojan, F; Fox, M; Kinsella, AR | 2 |
| Hamrell, MR | 1 |
| Martin, DS; Sawyer, RC; Spiegelman, S; Stolfi, RL; Young, CW | 1 |
| Schimke, RT; Sharma, RC | 1 |
| Allegra, CJ; Grogan, L; Sotos, GA | 1 |
| Abbondandolo, A; Bonatti, S; Bozzo, S; Miele, M; Moro, F; Ottaggio, L; Simili, M | 1 |
| Buyse, M; Le Bourgeois, JP; Lévy, E; Piedbois, P | 1 |
| Machover, D | 1 |
| Almasan, A; Bertino, JR; Bradley, A; Kelly, RE; Lee, EY; Li, W; Wahl, GM; Yin, Y | 1 |
| Barsukov, IL; Basran, J; Casarotto, MG; Roberts, GC | 1 |
| Huang, A; Wright, JA | 1 |
| Hussain, A; Melera, PW; Protzman, J; Yang, H | 1 |
| Heerschap, A; Hofs, HP; Kamm, VJ; Rietjens, IM; Rosenbusch, G; Vervoort, J; Wagener, DJ | 1 |
| Goz, B; Jeffs, L | 1 |
| Stambrook, PJ; Wani, MA; Xu, X | 1 |
| Ahlgren, JD; Anderson, N; Kemeny, N; Lokich, JJ | 1 |
| Colofiore, J; Kemeny, N; Martin, D; Sawyer, R; Schneider, A; Seiter, K; Williams, L | 1 |
| Kinsella, A; Pickard, M | 1 |
| Blomgren, H; Ragnhammar, P | 1 |
| Chernova, OB; Gilbert, C; Poupon, MF; Smith, KA; Stark, GR | 1 |
| Kinsella, AR; Pickard, M; Smith, D | 1 |
| Köhne, CH; Schmoll, HJ; Schöffski, P; Wilke, H | 1 |
| Benkovic, SJ; Cannon, WR; Garrison, BJ | 1 |
| Fan, H; Huang, A; Taylor, WR; Wright, JA | 1 |
| Berns, T; Harstrick, A; Hiddemann, W; Köhne, CH; Preusser, P; Schmoll, HJ; Seeber, S; Strumberg, D; Wilke, H | 1 |
| Bokemeyer, C; Dörken, B; Harstrick, A; Hiddemann, W; Köhne, CH; Schmoll, HJ; Schöffski, P; Wilke, H | 1 |
| Almasan, A; Brody, LL; Paulson, TG; Wahl, GM | 1 |
| Ardalan, B; Franceschi, D; Jaime, M; Luis, R | 1 |
| Büchele, T; Dempke, W; Grothey, A; Schmoll, HJ | 1 |
| Kwon, GS; Li, Y | 1 |
| Chan, YL; Chik, KW; Lau, KY; Li, CK; Roebuck, DJ; Yeung, KW; Yuen, MP | 1 |
| Amin, K; Brown, CS; Bruno, MS; Heath, TD; Ng, KY | 1 |
| Liu, XY; Matherly, LH | 1 |
| Baron, B; Bleiberg, H; Blijham, GH; Couvreur, ML; De Greve, J; Genicot, B; Jansen, RL; Kok, TC; Nortier, JW; Wagener, T; Wils, J | 1 |
| CUTTS, JH | 1 |
| GREENBERG, NH; MEAD, JA; SCHRECKER, AW; SEEGER, DR; TOMCUFCIK, AS | 1 |
| Lehnert, S; Li, Y; Owusu, A | 1 |
| Denmeade, SR; Gady, AM; Gillies, SD; Lo, KM; Mhaka, A; Rosen, DM | 1 |
| Leach, F | 1 |
| Abrey, LE; DeAngelis, LM; Koutcher, JA; Lis, E; Panageas, KS; Raizer, JJ; Xu, S; Zakian, KL | 1 |
| Kemeny, NE; Leonard, GD | 1 |
| Blamek, S; Ficek, K; Miszczyk, L; Sońta-Jakimczyk, D; Syguła, D; Tarnawski, R | 1 |
| Guo, L; He, D; Jiang, B; Li, Y; Ma, L; Ouyang, L | 1 |
| Chen, J; Fan, J; Hong, R; Li, J; Wang, S; Wang, Y; Wu, M; Xia, W; Xia, X; Xu, F; Zhan, Q; Zhang, K; Zhang, W | 1 |
17 review(s) available for aspartic acid and methotrexate
| Article | Year |
|---|---|
Chemotherapeutic strategies in metastatic colorectal cancer: an overview of current clinical trials.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Clinical Trials as Topic; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Infusions, Intravenous; Interferons; Leucovorin; Methotrexate; Phosphonoacetic Acid | 1992 |
Chemotherapy of advanced cancer of the colon and rectum.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Fluorouracil; Humans; Leucovorin; Methotrexate; Phosphonoacetic Acid; Rectal Neoplasms | 1991 |
Role of thymidine in biochemical modulation: a review.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cytarabine; Deoxycytidine Kinase; DNA Replication; DNA, Neoplasm; Drug Evaluation; Drug Synergism; Fluorouracil; Folic Acid Antagonists; Humans; Interphase; Kinetics; Leukemia; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Nucleic Acid Synthesis Inhibitors; Nucleotides; Phosphonoacetic Acid; RNA, Neoplasm; Species Specificity; Thymidine | 1987 |
Biochemical modulation: application of laboratory models to the clinic.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cytarabine; Dose-Response Relationship, Drug; Drug Evaluation; Fluorouracil; Humans; Methotrexate; Neoplasms, Experimental; Organophosphorus Compounds; Phosphonoacetic Acid; Thymidine | 1986 |
Isozymes of aspartate aminotransferase in tissues and blood of man.
Topics: Acute Disease; Adult; Aging; Alpha-Globulins; Animals; Aspartate Aminotransferases; Aspartic Acid; Beta-Globulins; Cattle; Choriocarcinoma; Cytoplasm; Dogs; Electrophoresis; Erythrocytes; Female; gamma-Globulins; Gluconeogenesis; Humans; Hydrogen-Ion Concentration; Immune Sera; Immunochemistry; In Vitro Techniques; Isoenzymes; Ketoglutaric Acids; Kinetics; Liver; Methotrexate; Mitochondria; Myocardium; Neoplasms; Organ Specificity; Phenylhydrazines; Pregnancy; Rabbits; Rats; Reticulocytes; Starch | 1966 |
Effect of human renal and hepatic disease on the pharmacokinetics of anticancer drugs.
Topics: Antineoplastic Agents; Aspartic Acid; Bleomycin; Cisplatin; Cyclophosphamide; Doxorubicin; Fluorouracil; Gallium; Humans; Kidney Diseases; Kinetics; Liver Diseases; Metabolic Clearance Rate; Methotrexate; Phosphonoacetic Acid; Protein Binding; Tegafur | 1982 |
Regional and systemic chemotherapy for advanced colorectal cancer. A review.
Topics: Antineoplastic Agents; Aspartic Acid; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Methotrexate; Phosphonoacetic Acid; Rectal Neoplasms; Tegafur | 1983 |
Neurological complications of antineoplastic therapy.
Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Aspartic Acid; Cisplatin; Cytarabine; Fluorouracil; Humans; Methotrexate; Nervous System Diseases; Phosphonoacetic Acid; Thymidine; Vinblastine; Vincristine | 1984 |
Preclinical and clinical aspects of biomodulation of 5-fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colorectal Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Idoxuridine; Immunologic Factors; Interferons; Leucovorin; Methotrexate; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil; Uridine; Zidovudine | 1994 |
[Chemotherapy of metastasizing cancers of the colon and rectum].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Fluorouracil; Humans; Interferons; Leucovorin; Methotrexate; Neoplasm Metastasis; Phosphonoacetic Acid; Rectal Neoplasms | 1993 |
The pharmacologic modulation of 5-fluorouracil with folinic acid, methotrexate, trimetrexate, and n-phosphonacetyl-l-aspartic acid (PALA). Mechanisms of the interactions and clinical data.
Topics: Aspartic Acid; Drug Interactions; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms; Phosphonoacetic Acid; Trimetrexate | 1994 |
Recent advances in the treatment of advanced colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Administration Schedule; Drug Interactions; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Hydroxyurea; Infusions, Intra-Arterial; Leucovorin; Methotrexate; Neoplasm Staging; Phosphonoacetic Acid; Prospective Studies; Randomized Controlled Trials as Topic | 1993 |
How to optimize the effect of 5-fluorouracil modulated therapy in advanced colorectal cancer.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Clinical Trials as Topic; Colorectal Neoplasms; Fluorouracil; Humans; Interferons; Leucovorin; Liver Neoplasms; Methotrexate; Phosphonoacetic Acid | 1995 |
Resistance to chemotherapeutic antimetabolites: a function of salvage pathway involvement and cellular response to DNA damage.
Topics: Animals; Antimetabolites, Antineoplastic; Aspartic Acid; DNA Damage; Drug Resistance; Fluorouracil; Humans; Methotrexate; Phosphonoacetic Acid; Purines; Pyrimidines; Tumor Suppressor Protein p53 | 1997 |
The dead end of 5-fluorouracil double modulation and promise of continuous infusion schedules in the treatment of metastatic colorectal cancer.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Combined Modality Therapy; Dipyridamole; Drug Administration Schedule; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Humans; Immunologic Factors; Infusions, Intravenous; Injections, Intravenous; Interferons; Leucovorin; Liver Neoplasms; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Neoplasm Proteins; Nucleotides; Palliative Care; Phosphonoacetic Acid; Randomized Controlled Trials as Topic; Thymidylate Synthase | 1996 |
Biomodulation of Fluorouracil in colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Clinical Trials as Topic; Colorectal Neoplasms; Drug Synergism; Fluorouracil; Humans; Interferon-alpha; Leucovorin; Methotrexate; Phosphonoacetic Acid; Trimetrexate | 1998 |
Where do we stand with 5-fluorouracil?
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Chronotherapy; Colorectal Neoplasms; Dipyridamole; Drug Synergism; Fluorouracil; Humans; Interferons; Leucovorin; Levamisole; Methotrexate; Phosphonoacetic Acid; Radiation-Sensitizing Agents; Trimetrexate; Zidovudine | 1999 |
4 trial(s) available for aspartic acid and methotrexate
| Article | Year |
|---|---|
A phase II trial of biochemical modulation using N-phosphonacetyl-L-aspartate, high-dose methotrexate, high-dose 5-fluorouracil, and leucovorin in patients with adenocarcinoma of unknown primary site.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms, Unknown Primary; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate; Uridine Triphosphate | 1992 |
The pharmacologic modulation of 5-fluorouracil with folinic acid, methotrexate, trimetrexate, and n-phosphonacetyl-l-aspartic acid (PALA). Mechanisms of the interactions and clinical data.
Topics: Aspartic Acid; Drug Interactions; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms; Phosphonoacetic Acid; Trimetrexate | 1994 |
Modulation of 5-fluorouracil with methotrexate and low-dose N-(phosphonacetyl)-L-aspartate in patients with advanced colorectal cancer. Results of a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Survival Analysis; Treatment Outcome | 1997 |
High-dose 5-fluorouracil plus low dose methotrexate plus or minus low-dose PALA in advanced colorectal cancer: a randomised phase II-III trial of the EORTC Gastrointestinal Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Disease-Free Survival; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Survival Analysis; Treatment Outcome | 2003 |
73 other study(ies) available for aspartic acid and methotrexate
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Biochemical and karyological properties of cells resistant to the quinazoline antifolate, methasquin.
Topics: Aspartic Acid; Cell Line; Cell Survival; Chromosome Aberrations; Drug Resistance; Glycine Hydroxymethyltransferase; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Tetrahydrofolate Dehydrogenase | 1978 |
Trimethoprim-resistant bacteria: cross-resistance patterns.
Topics: Aspartic Acid; Bacteria; Bacterial Infections; Cross Reactions; Drug Resistance, Microbial; Humans; Methotrexate; Proguanil; Pyrimethamine; R Factors; Species Specificity; Trimethoprim; Urine | 1977 |
Metaphase chromosome anomaly: association with drug resistance and cell-specific products.
Topics: Aspartic Acid; Cell Line; Chromosome Aberrations; Chromosomes; DNA Replication; Drug Resistance; Methotrexate; Neuroblastoma; Tetrahydrofolate Dehydrogenase | 1976 |
Competitive dihydrofolate reductase binding assay of triazinate (NSC-139105), methasquin (NSC-122870), and aminopterin (NSC739).
Topics: Aminopterin; Aspartic Acid; Folic Acid Antagonists; Methotrexate; Protein Binding; Tetrahydrofolate Dehydrogenase | 1976 |
A basis for the difference in toxicity of methotrexate, aminopterin and methasquin in mice.
Topics: Aminopterin; Animals; Antineoplastic Agents; Aspartic Acid; Intestinal Absorption; Intestine, Small; Kinetics; Lethal Dose 50; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Structure-Activity Relationship | 1975 |
Further evidence for a basis of selective activity and relative responsiveness during antifolate therapy of murine tumors.
Topics: Aminopterin; Animals; Aspartic Acid; Carcinoma, Ehrlich Tumor; Chick Embryo; DNA, Neoplasm; Folic Acid Antagonists; Intestine, Small; Leukemia L1210; Liver; Lymphoma; Methotrexate; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Quinazolines; Sarcoma 180; Tetrahydrofolate Dehydrogenase; Time Factors | 1975 |
Elevation of dihydrofolate reductase, thymidylate synthetase, and thymidine kinase in cultured mammalian cells after exposure to folate antagonists.
Topics: Aspartic Acid; Cells, Cultured; Dose-Response Relationship, Drug; Folic Acid Antagonists; Kinetics; Leukocytes; Methotrexate; Methyltransferases; Quinazolines; Temperature; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Thymidylate Synthase; Triazines | 1976 |
Hydroxyurea accelerates loss of extrachromosomally amplified genes from tumor cells.
Topics: Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carcinoma, Squamous Cell; Cell Division; Chromosome Deletion; Dihydroorotase; DNA Replication; Drug Resistance; Gene Amplification; Humans; Hydroxyurea; Methotrexate; Multienzyme Complexes; Phosphonoacetic Acid; Plasmids; Tumor Cells, Cultured; Vinblastine | 1991 |
Decreasing sensitivity to cytotoxic agents parallels increasing tumorigenicity in human fibroblasts.
Topics: Aspartic Acid; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Drug Resistance; Fibroblasts; Gene Amplification; Humans; Methotrexate; Phenotype; Phosphonoacetic Acid | 1991 |
High frequency of double drug resistance in the B16 melanoma cell line.
Topics: Amides; Animals; Antineoplastic Agents; Aspartic Acid; Cell Line; Colony-Forming Units Assay; Drug Resistance; Drug Synergism; Gene Amplification; Melanoma; Methotrexate; Mice; Ouabain; Phosphonoacetic Acid; Pyrazoles; Ribonucleosides; Ribose | 1990 |
Methotrexate: studies on cellular metabolism. IV. Effect on the mitochondrial oxidation of cytosolic-reducing equivalents in HeLa cells.
Topics: Arsenic; Arsenites; Aspartate Aminotransferases; Aspartic Acid; Cytosol; HeLa Cells; Humans; Malate Dehydrogenase; Malates; Methotrexate; Mitochondria; Oxidation-Reduction | 1990 |
Normal diploid human and rodent cells lack a detectable frequency of gene amplification.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Cell Division; Cells, Cultured; Diploidy; Drug Resistance; Fibroblasts; Gene Amplification; Humans; Methotrexate; Phenotype; Phosphonoacetic Acid; Rats; Reference Values; Species Specificity; Tumor Cells, Cultured | 1990 |
Serum-induced leakage of negatively charged liposomes at nanomolar lipid concentrations.
Topics: Animals; Aspartic Acid; Cattle; Drug Carriers; Folic Acid Antagonists; Humans; Lipoproteins; Liposomes; Methotrexate; Osmolar Concentration; Phospholipids; Serum Albumin, Bovine; Temperature | 1990 |
Introduction to 5-fluorouracil modulation.
Topics: Antimetabolites, Antineoplastic; Aspartic Acid; Drug Interactions; Fluorouracil; Humans; Leucovorin; Methotrexate; Phosphonoacetic Acid; Uridine | 1990 |
Phase I trial of PALA, methotrexate, fluorouracil, leucovorin, and uridine rescue in patients with advanced cancer. The use of uridine to decrease fluorouracil toxicity.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Phosphonoacetic Acid; Uridine | 1990 |
Phase I trial of N-(phosphonacetyl)-L-aspartate, methotrexate, and 5-fluorouracil with leucovorin rescue in patients with advanced cancer.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Bone Marrow; Carcinoma, Squamous Cell; Colorectal Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Leucovorin; Male; Methotrexate; Pentosephosphates; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate | 1989 |
The presence of amplified regions affects the stability of chromosomes in drug-resistant Chinese hamster cells.
Topics: Animals; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Cycle; Cell Line; Chromosomes; Cricetinae; Cricetulus; Dihydroorotase; Drug Resistance; Gene Amplification; Methotrexate; Multienzyme Complexes; Neoplasm Proteins; Phosphonoacetic Acid; Tetrahydrofolate Dehydrogenase | 1989 |
1-beta-D-arabinofuranosylcytosine enhancement of resistance to several antineoplastic drugs in mammalian tissue culture cells.
Topics: Animals; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Line; Cricetinae; Cytarabine; Dihydroorotase; Dose-Response Relationship, Drug; Drug Resistance; Floxuridine; Gene Amplification; Methotrexate; Multienzyme Complexes; Phosphonoacetic Acid; Time Factors; Vincristine | 1989 |
The concentration of 5-phosphoribosyl 1-pyrophosphate in monolayer tumor cells and the effect of various pyrimidine antimetabolites.
Topics: Animals; Aspartic Acid; Cell Line; Cells, Cultured; Fluorouracil; Humans; Methotrexate; Neoplasms; Ornithine Decarboxylase; Orotate Phosphoribosyltransferase; Pentosephosphates; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate | 1985 |
Drug resistance in KHT fibrosarcoma cell lines with different metastatic ability.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Cell Line; Drug Resistance; Fibrosarcoma; Gene Amplification; Methotrexate; Mice; Neoplasm Metastasis; Organophosphorus Compounds; Phosphonoacetic Acid | 1989 |
Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli.
Topics: Asparagine; Aspartic Acid; Binding Sites; Escherichia coli; Kinetics; Mathematics; Methotrexate; Models, Theoretical; Mutation; Protein Binding; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase | 1988 |
Probing the salt bridge in the dihydrofolate reductase-methotrexate complex by using the coordinate-coupled free-energy perturbation method.
Topics: Aspartic Acid; Calorimetry; Kinetics; Methotrexate; Mutation; Protein Binding; Tetrahydrofolate Dehydrogenase; Thermodynamics | 1988 |
TPA enhancement of the recovery of methotrexate and N-phosphonacetyl L-aspartate resistant mouse 3T6 cell clones is associated with transient alterations of cell cycle progression.
Topics: Animals; Aspartic Acid; Cell Cycle; Cell Line; Cell Survival; Cricetinae; Drug Interactions; Drug Resistance; Interphase; Methotrexate; Mice; Organophosphorus Compounds; Phosphonoacetic Acid; Tetradecanoylphorbol Acetate | 1988 |
Phenotypic resistance to methotrexate and N-phosphonacetyl L-aspartate is induced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: Animals; Aspartic Acid; Cell Line; Drug Interactions; Drug Resistance; Gene Amplification; Methotrexate; Organophosphorus Compounds; Phenotype; Phosphonoacetic Acid; Tetradecanoylphorbol Acetate; Tetrahydrofolate Dehydrogenase | 1988 |
Functional role of aspartic acid-27 in dihydrofolate reductase revealed by mutagenesis.
Topics: Aspartic Acid; Crystallography; Deuterium; Escherichia coli; Kinetics; Methotrexate; Mutation; Protein Binding; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1986 |
Nuclear magnetic resonance study of the state of protonation of inhibitors bound to mutant dihydrofolate reductase lacking the active-site carboxyl.
Topics: Asparagine; Aspartic Acid; Binding Sites; Carbon Isotopes; Escherichia coli; Kinetics; Magnetic Resonance Spectroscopy; Methotrexate; Mutation; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1986 |
Generation of drug-resistant variants in metastatic B16 mouse melanoma cell lines.
Topics: Animals; Aspartic Acid; Cell Line; Drug Resistance; Gene Amplification; Mathematics; Melanoma; Methotrexate; Mice; Neoplasm Metastasis; Organophosphorus Compounds; Phenotype; Phosphonoacetic Acid | 1987 |
Hamster cells with increased rates of DNA amplification, a new phenotype.
Topics: Amides; Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Cell Line; Coformycin; Cricetinae; DNA; Drug Resistance; Gene Amplification; Genes; Kidney; Methotrexate; Mutation; Ouabain; Phenotype; Phosphonoacetic Acid; Pyrazoles; Ribonucleosides; Ribose; Tetrahydrofolate Dehydrogenase | 1987 |
Cancer chemotherapy: past is prologue.
Topics: 6-Aminonicotinamide; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Female; Fluorouracil; Humans; Male; Mammary Neoplasms, Experimental; Methotrexate; Methylthioinosine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Phosphonoacetic Acid | 1985 |
The apparent induction of thymidylate synthetase by amethopterin.
Topics: Animals; Aspartic Acid; Benzoates; Carcinoma, Hepatocellular; Enzyme Induction; Folic Acid; Hepatectomy; Liver; Liver Neoplasms; Liver Regeneration; Methotrexate; Methyltransferases; Neoplasms, Experimental; Quinazolines; Rats; Thymine Nucleotides; Uracil Nucleotides | 1971 |
Folate reductase of the amethopterin-resistant Streptococcus faecium var. durans-Ak. I. Inhibition by amethopterin and methasquin, a new quinazoline antifolate.
Topics: Aspartic Acid; Chromatography, DEAE-Cellulose; Electrophoresis; Folic Acid Antagonists; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Molecular Weight; NADP; Potassium Chloride; Quinazolines; Streptococcus; Tetrahydrofolate Dehydrogenase | 1970 |
Dihydrofolate reductase activity in strains of Streptococcus faecium var. durans resistant to methasquin and amethopterin.
Topics: Aspartic Acid; Benzoates; Chromatography, Gel; Drug Resistance, Microbial; Folic Acid Antagonists; Genetics, Microbial; Methotrexate; Mutation; NADP; Quinolines; Spectrophotometry; Streptococcus; Tetrahydrofolate Dehydrogenase | 1972 |
Comparative studies on the transport of aminopterin, methotrexate, and methasquin by the L1210 leukemia cell.
Topics: Aminopterin; Animals; Antineoplastic Agents; Ascitic Fluid; Aspartic Acid; Benzoates; Binding, Competitive; Biological Transport, Active; Cell Line; Cells, Cultured; Diffusion; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Quinazolines; Streptococcus pneumoniae; Temperature; Tetrahydrofolate Dehydrogenase; Time Factors; Tritium | 1972 |
Drug response, dihydrofolate reductase, and cytogenetics of amethopterin-resistant Chinese hamster cells in vitro.
Topics: Animals; Aspartic Acid; Benzoates; Cell Line; Chromosome Aberrations; Cricetinae; Drug Resistance; Folic Acid Antagonists; In Vitro Techniques; Karyotyping; Methotrexate; Pharmacogenetics; Quinazolines; Tetrahydrofolate Dehydrogenase | 1972 |
Purification and properties of carboxypeptidase G 1 .
Topics: Ammonium Sulfate; Aspartic Acid; Carboxypeptidases; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Paper; Electrophoresis, Disc; Enzyme Activation; Folic Acid; Glutamates; Hydrogen-Ion Concentration; Hydrolysis; Isoelectric Focusing; Methotrexate; Molecular Weight; Pseudomonas; Zinc | 1971 |
The enzymatic hydrolysis of folate analogues.
Topics: Aspartic Acid; Carboxypeptidases; Folic Acid; Glutamates; Methods; Methotrexate; Peptide Hydrolases; Pseudomonas; Pteridines; Soil Microbiology; Spectrophotometry | 1968 |
Fluctuations in phosphoribosyl pyrophosphate levels in monolayer tumor cell lines. Effects of drugs.
Topics: Animals; Aspartic Acid; Buffers; Cell Line; Cytological Techniques; Fibroblasts; Humans; Melanoma; Methotrexate; Mice; Pentosephosphates; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate; Purine Nucleosides; Trypsin | 1984 |
Repetitive DNA sequences in methotrexate- and methasquin-sensitive and -resistant Chinese hamster cell lines.
Topics: Animals; Aspartic Acid; Base Sequence; Cell Line; Centrifugation, Density Gradient; Cricetinae; Cricetulus; DNA; DNA Replication; DNA Restriction Enzymes; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Lung; Methotrexate; Phenotype | 1980 |
Effect of 12-O-tetradecanoylphorbol-13-acetate on selection of drug-resistant phenotypes in rodent cells.
Topics: Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Cadmium; Cell Line; Cells, Cultured; Clone Cells; Cricetinae; Cricetulus; Drug Resistance; Lung; Methotrexate; Mice; Phenotype; Phorbols; Phosphonoacetic Acid; Tetradecanoylphorbol Acetate; Tetrahydrofolate Dehydrogenase | 1984 |
Inhibition of dihydrofolate reductase and cell growth by antifolates in a methotrexate-resistant cell line.
Topics: Adamantane; Animals; Aspartic Acid; Cell Division; Cell Line; Drug Resistance; Folic Acid Antagonists; Methotrexate; Mice; Pyrimethamine; Pyrimidines | 1984 |
Improved therapeutic index with sequential N-phosphonacetyl-L-aspartate plus high-dose methotrexate plus high-dose 5-fluorouracil and appropriate rescue.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Drug Therapy, Combination; Female; Fluorouracil; Leucovorin; Male; Methotrexate; Mice; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine | 1983 |
Effect of tumor promoter 12-O-tetradecanoylphorbol-13-acetate on recovery of methotrexate-, N-(phosphonacetyl)-L-aspartate-, and cadmium-resistant colony-forming mouse and hamster cells.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Cadmium; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Drug Resistance; Kinetics; Lung; Methotrexate; Mice; Organophosphorus Compounds; Phorbols; Phosphonoacetic Acid; Tetradecanoylphorbol Acetate | 1983 |
The propensity for gene amplification: a comparison of protocols, cell lines, and selection agents.
Topics: Animals; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Line, Transformed; CHO Cells; Cricetinae; Demecolcine; Dihydroorotase; Dose-Response Relationship, Drug; Drug Resistance; Fibroblasts; Folic Acid Antagonists; Gene Amplification; HeLa Cells; Humans; Lethal Dose 50; Methotrexate; Multienzyme Complexes; Phosphonoacetic Acid; Research Design; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1994 |
p53 expression in normal versus transformed mammalian cells.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Aspartic Acid; Burkitt Lymphoma; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; CHO Cells; Cholera Toxin; Cricetinae; Drug Resistance; Embryo, Mammalian; Gene Expression; Genes, p53; Humans; Immunohistochemistry; L Cells; Lymphocytes; Methotrexate; Mice; Phosphonoacetic Acid; Reference Values; Theophylline; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1995 |
Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.
Topics: Animals; Apoptosis; Aspartic Acid; Carrier Proteins; Cell Cycle Proteins; Cell Nucleus; Cells, Cultured; DNA-Binding Proteins; E2F Transcription Factors; Genes, p53; Genes, Retinoblastoma; Methotrexate; Mice; Phosphonoacetic Acid; Retinoblastoma Protein; Retinoblastoma-Binding Protein 1; S Phase; Transcription Factor DP1; Transcription Factors | 1995 |
Role of the active-site carboxylate in dihydrofolate reductase: kinetic and spectroscopic studies of the aspartate 26-->asparagine mutant of the Lactobacillus casei enzyme.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Lacticaseibacillus casei; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Oxidation-Reduction; Point Mutation; Spectrophotometry; Tetrahydrofolate Dehydrogenase | 1995 |
Fibroblast growth factor mediated alterations in drug resistance, and evidence of gene amplification.
Topics: Animals; Antineoplastic Agents; Aspartate Carbamoyltransferase; Aspartic Acid; Blotting, Southern; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Line; Dihydroorotase; DNA; Drug Resistance; Fibroblast Growth Factor 2; Fibroblast Growth Factor 4; Fibroblast Growth Factors; Fibroblasts; Gene Amplification; Hydroxyurea; Methotrexate; Mice; Multienzyme Complexes; Phosphonoacetic Acid; Proto-Oncogene Proteins; Ribonucleotide Reductases; Suramin; Tetrahydrofolate Dehydrogenase; Transfection | 1994 |
Selection for the expression of one form of Chinese hamster dihydrofolate reductase over another during growth in methotrexate.
Topics: Alleles; Animals; Asparagine; Aspartic Acid; Blotting, Southern; Cell Division; Cell Survival; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; DNA, Complementary; Methotrexate; Plasmids; Restriction Mapping; Selection, Genetic; Tetrahydrofolate Dehydrogenase; Transfection | 1994 |
Effect of modulators on 5-fluorouracil metabolite patterns in murine colon carcinoma determined by in vitro 19F nuclear magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Interferon-alpha; Leucovorin; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Mice, Inbred C57BL; Phosphonoacetic Acid; Rats; Tumor Cells, Cultured | 1994 |
The enhancement of the frequency of resistance to N-phosphonoacetyl-L-aspartate and methotrexate by 1-beta-D-arabinofuranosylcytosine: the effect of dipyridamole.
Topics: Animals; Aspartic Acid; Cell Line, Transformed; Cricetinae; Cytarabine; Dipyridamole; Drug Resistance; Drug Synergism; Humans; Methotrexate; Nucleosides; Phosphonoacetic Acid; Thioinosine | 1994 |
Increased methotrexate resistance and dhfr gene amplification as a consequence of induced Ha-ras expression in NIH 3T3 cells.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Aspartic Acid; Cell Transformation, Neoplastic; Drug Resistance; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, ras; Isopropyl Thiogalactoside; Methotrexate; Mice; Phosphonoacetic Acid; Tetrahydrofolate Dehydrogenase | 1994 |
Uridine allows dose escalation of 5-fluorouracil when given with N-phosphonacetyl-L-aspartate, methotrexate, and leucovorin.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Diarrhea; Drug Synergism; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Mouth Mucosa; Neoplasms; Phosphonoacetic Acid; Stomatitis; Uridine | 1993 |
Influence of both salvage and DNA damage response pathways on resistance to chemotherapeutic antimetabolites.
Topics: Antimetabolites; Aspartic Acid; Cell Survival; DNA; Dose-Response Relationship, Drug; Drug Resistance; Fibroblasts; Humans; Methotrexate; Phosphonoacetic Acid; Tumor Cells, Cultured | 1996 |
Inefficient growth arrest in response to dNTP starvation stimulates gene amplification through bridge-breakage-fusion cycles.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Cell Division; Cell Line; Cloning, Molecular; Cricetinae; DNA Damage; Fluorouracil; Gene Amplification; Growth Inhibitors; Humans; In Situ Hybridization, Fluorescence; Methotrexate; Phosphonoacetic Acid; Pyrimidine Nucleotides; Tumor Cells, Cultured | 1996 |
Consideration of the pH-dependent inhibition of dihydrofolate reductase by methotrexate.
Topics: 4-Aminobenzoic Acid; Acetic Acid; Apoenzymes; Aspartic Acid; Binding Sites; Enzyme Inhibitors; Folic Acid Antagonists; Hydrogen-Ion Concentration; Ligands; Methotrexate; Protein Denaturation; Protein Structure, Tertiary; Static Electricity; Tetrahydrofolate Dehydrogenase; Thermodynamics | 1997 |
Ribonucleotide reductase R2 gene expression and changes in drug sensitivity and genome stability.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Antisense Elements (Genetics); Aspartic Acid; Drug Resistance, Neoplasm; Gene Amplification; Gene Expression Regulation, Enzymologic; Genes, p53; Genetic Vectors; Hydroxyurea; L Cells; Methotrexate; Mice; Phosphonoacetic Acid; Retroviridae; Ribonucleotide Reductases; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 1997 |
Modulation of 5-fluorouracil with methotrexate and low-dose N-(phosphonacetyl)-L-aspartate (PALA) is inactive in advanced pancreatic carcinoma.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Pancreatic Neoplasms; Phosphonoacetic Acid | 1997 |
Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage.
Topics: Aspartic Acid; Cell Cycle; Cell Cycle Proteins; DNA Damage; Drug Resistance; Fibrosarcoma; Gene Amplification; Humans; Methotrexate; Models, Genetic; Nucleotides; Phosphonoacetic Acid; Selection, Genetic; Skin Neoplasms; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
Methotrexate esters of poly(ethylene oxide)-block-poly(2-hydroxyethyl-L-aspartamide). Part I: Effects of the level of methotrexate conjugation on the stability of micelles and on drug release.
Topics: Antimetabolites, Antineoplastic; Aspartic Acid; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drug Carriers; Methotrexate; Micelles; Particle Size; Polyethylene Glycols; Solubility | 2000 |
Long-term cerebral metabolite changes on proton magnetic resonance spectroscopy in patients cured of acute lymphoblastic leukemia with previous intrathecal methotrexate and cranial irradiation prophylaxis.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Aspartic Acid; Brain; Brain Infarction; Cerebrovascular Disorders; Child; Choline; Cranial Irradiation; Creatine; Female; Humans; Injections, Spinal; Magnetic Resonance Spectroscopy; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Time Factors | 2001 |
LDL induced association of anionic liposomes with cells and delivery of contents as shown by the increase in potency of liposome dependent drugs.
Topics: Animals; Anions; Antimetabolites, Antineoplastic; Aspartic Acid; Cell Line; Chlorocebus aethiops; CHO Cells; Cricetinae; Drug Delivery Systems; Lipoproteins, LDL; Liposomes; Methotrexate; Phosphatidylglycerols; Phospholipids; Phosphonoacetic Acid; Receptors, LDL | 2001 |
Functional interactions between arginine-133 and aspartate-88 in the human reduced folate carrier: evidence for a charge-pair association.
Topics: Amino Acid Sequence; Animals; Arginine; Aspartic Acid; Biological Transport; Carrier Proteins; Cricetinae; Humans; K562 Cells; Leucovorin; Membrane Transport Proteins; Methotrexate; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Rats; Reduced Folate Carrier Protein; Sequence Homology, Amino Acid; Structure-Activity Relationship; Transfection | 2001 |
EFFECTS OF OTHER AGENTS ON THE BIOLOGIC RESPONSES TO VINCALEUKOBLASTINE.
Topics: 2-Aminopurine; Aminopterin; Animals; Aspartic Acid; Azaguanine; Biological Products; Colchicine; Cortisone; Glutamates; Leukemia; Leukemia L1210; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Pharmacology; Purines; Research; Tryptophan; Vinblastine | 1964 |
THE PHARMACOLOGICAL AND BIOCHEMICAL ACTIVITY OF 4-AMINO-4-DEOXY-10-METHYLPTEROYLASPARTIC ACID.
Topics: Adenine; Amino Acids; Animals; Aspartic Acid; Enzyme Inhibitors; Folic Acid; Formates; Kinetics; Leukemia L1210; Liver; Methotrexate; Mice; Oxidoreductases; Pharmacology; Research | 1965 |
Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam radiotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Brain Neoplasms; Bromodeoxyuridine; Cell Line, Tumor; Combined Modality Therapy; Drug Combinations; Drug Implants; Fluorouracil; Glioma; Immunologic Factors; Methotrexate; Phosphonoacetic Acid; Radiation-Sensitizing Agents; Rats | 2004 |
Use of methotrexate-based peptide substrates to characterize the substrate specificity of prostate-specific membrane antigen (PSMA).
Topics: Animals; Antigens, Surface; Aspartic Acid; Blotting, Western; Extracellular Fluid; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Immunoglobulin gamma-Chains; Immunoglobulin kappa-Chains; Male; Methotrexate; Mice; Peptide Fragments; Prodrugs; Prostatic Neoplasms; Recombinant Fusion Proteins; Substrate Specificity; Tumor Cells, Cultured | 2004 |
Targeting prostate-specific membrane antigen in cancer therapy: can molecular medicine be brought to the surface?
Topics: Antigens, Surface; Aspartic Acid; Drug Delivery Systems; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Male; Methotrexate; Peptide Fragments; Prodrugs; Prostatic Neoplasms; Recombinant Fusion Proteins; Substrate Specificity | 2004 |
Proton magnetic resonance spectroscopy in immunocompetent patients with primary central nervous system lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Aspartic Acid; Central Nervous System Neoplasms; Choline; Creatine; Disease Progression; Dose-Response Relationship, Drug; Female; Humans; Immunocompetence; Lactic Acid; Lipid Metabolism; Lymphoma; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Protons; Survival Analysis | 2005 |
Continued survival of more than ten years, without resection of metastatic disease, in patients with metastatic colorectal cancer treated with biomodulated fluorouracil: report of two cases.
Topics: Acetates; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Immunologic Factors; Leucovorin; Liver Neoplasms; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Remission Induction; Uridine; Vitamin B Complex | 2006 |
Evaluation of the late effects of CNS prophylactic treatment in childhood acute lymphoblastic leukemia (ALL) using magnetic resonance spectroscopy.
Topics: Adolescent; Aspartic Acid; Brain Injuries; Case-Control Studies; Child; Child, Preschool; Choline; Cranial Irradiation; Creatine; Drug Administration Routes; Drug Therapy; Female; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tissue Distribution | 2010 |
Synthesis of novel dendrimers having aspartate grafts and their ability to enhance the aqueous solubility of model drugs.
Topics: Aspartic Acid; Dendrimers; Drug Carriers; Histidine; Hydrogen-Ion Concentration; Methotrexate; Naproxen; Peptides; Pharmaceutical Preparations; Solubility; Surface Properties; Temperature; Water | 2010 |
Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation.
Topics: Animals; Aspartate Aminotransferase, Mitochondrial; Aspartic Acid; Biomarkers, Tumor; BRCA1 Protein; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Ketoglutaric Acids; Methotrexate; Mice; Middle Aged; Models, Biological; Phenotype; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; Transcription, Genetic | 2019 |