aspartic acid has been researched along with metformin in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 4 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Bush, LN; Davidson, SM; Freinkman, E; Gitego, N; Gui, DY; Hosios, AM; Luengo, A; Sullivan, LB; Thomas, CJ; Vander Heiden, MG | 1 |
| Bush, LN; Danai, LV; Diehl, FF; Elmiligy, S; Hosios, AM; Lau, AN; Lewis, CA; Luengo, A; Malstrom, S; Sullivan, LB; Vander Heiden, MG | 1 |
| Agius, L; Alshawi, A | 1 |
| Jiao, Y; Li, M; Li, Y; Liang, J; Ma, Y; Wang, X; Zeng, Y; Zhang, Y; Zhu, Q | 1 |
| Christofk, HR; Halbrook, CJ; Knott, SRV; Krall, AS; Lyssiotis, CA; Mittelman, SD; Momcilovic, M; Mullen, PJ; Schmid, EW; Shackelford, DB; Surjono, F; Thambundit, A | 1 |
| Bharti, S; Bhujwalla, Z; Gabrielson, E; Tully, E; Woo, J | 1 |
| Abzalimov, RR; He, Y; Soliman, GA | 1 |
7 other study(ies) available for aspartic acid and metformin
| Article | Year |
|---|---|
Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.
Topics: Animals; Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Electron Transport Complex I; Homeostasis; Humans; Metformin; Mice, Nude; Mitochondria; NAD; Neoplasms; Pyruvic Acid; Tumor Microenvironment | 2016 |
Aspartate is an endogenous metabolic limitation for tumour growth.
Topics: Animals; Antineoplastic Agents; Asparaginase; Aspartic Acid; Cell Proliferation; Drug Resistance, Neoplasm; Energy Metabolism; Guinea Pigs; HCT116 Cells; HEK293 Cells; HeLa Cells; Humans; Male; Metabolomics; Metformin; Mice, Nude; Mice, Transgenic; Neoplasms; Signal Transduction; Time Factors; Tumor Burden; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2018 |
Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism.
Topics: Animals; Aspartic Acid; Cells, Cultured; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Glycolysis; Hepatocytes; Hypoglycemic Agents; Lactic Acid; Malates; Male; Metformin; Mice; Mice, Inbred C57BL; Mitochondria, Liver; NAD; Oxidation-Reduction; Phosphofructokinase-1; Rats; Rats, Wistar | 2019 |
A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo.
Topics: Animals; Aspartic Acid; CDC2 Protein Kinase; Citric Acid Cycle; CRISPR-Cas Systems; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Drug Synergism; Fatty Acids; Gene Knockdown Techniques; Genome, Human; High-Throughput Nucleotide Sequencing; Humans; MCF-7 Cells; Metformin; Mice; Neoplasms; Protein Kinase Inhibitors; TOR Serine-Threonine Kinases | 2020 |
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.
Topics: Activating Transcription Factor 4; Animals; Asparagine; Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Diet; Electron Transport Chain Complex Proteins; Humans; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred NOD; Mitochondria; Neoplasms; Nucleotides; Survival Rate | 2021 |
Biguanide drugs enhance cytotoxic effects of cisplatin by depleting aspartate and NAD+ in sensitive cancer cells.
Topics: Antineoplastic Agents; Aspartic Acid; Cisplatin; Metformin; NAD; Neoplasms; Pharmaceutical Preparations | 2021 |
mTORC1 and mTORC2 Complexes Regulate the Untargeted Metabolomics and Amino Acid Metabolites Profile through Mitochondrial Bioenergetic Functions in Pancreatic Beta Cells.
Topics: Amino Acids; Animals; Aspartic Acid; Chromatography, Liquid; Energy Metabolism; Insulin-Secreting Cells; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Metformin; Mice; Oxygen; Signal Transduction; Sirolimus; Tandem Mass Spectrometry; TOR Serine-Threonine Kinases | 2022 |