aspartic acid has been researched along with manganese in 159 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (35.22) | 18.7374 |
| 1990's | 35 (22.01) | 18.2507 |
| 2000's | 49 (30.82) | 29.6817 |
| 2010's | 16 (10.06) | 24.3611 |
| 2020's | 3 (1.89) | 2.80 |
| Authors | Studies |
|---|---|
| Cazzulo, JJ; Milrad de Forchetti, SR | 1 |
| Baugh, CL; Cox, DL | 1 |
| Hamaguchi, K; Ikeda, K; Nakae, Y | 1 |
| Cooney, PH; Freese, E | 1 |
| Barry, BA; Boerner, RJ; Debus, RJ; Nguyen, AP | 1 |
| de Pater, BS; Díaz, CL; Hoedemaeker, FJ; Kijne, JW; Lugtenberg, BJ; van Eijsden, RR | 1 |
| Chesler, M; Rice, ME | 1 |
| Diner, BA; Nixon, PJ | 1 |
| Nicholson, C; Rice, ME | 1 |
| Mayo, KH; Tener, DM | 1 |
| Sato, H; Yamamoto, C | 1 |
| Hablitz, JJ | 2 |
| Mori, M; Shiio, I | 1 |
| Colman, RF | 1 |
| Hatch, MD; Kagawa, T | 1 |
| Chibata, I; Sato, T; Tosa, T | 1 |
| Burns, VW; Wong, DL | 1 |
| Din, GA; Lees, H; Suzuki, I | 1 |
| Orr, GR; Patterson, MK | 1 |
| Bright, HJ; Fields, GA | 1 |
| Gallo, AA; Sable, HZ; Swift, TJ | 1 |
| Cheung, HS; Cushman, DW | 1 |
| Ehrlich, RS; Takahashi, M | 1 |
| Colman, RF; Siliski, JM | 1 |
| Sanwal, BD; Smando, R; Waygood, EB | 1 |
| Chibata, I; Mori, T; Sato, T; Tosa, T | 1 |
| Achar, BS; Rao, NA; Savithri, HS; Vaidyanathan, CS | 1 |
| Lamont, HC; Staudenbauer, WL; Strominger, JL | 1 |
| Ainsworth, CF; Hardman, KD | 1 |
| Corwin, LM; Fanning, GR | 1 |
| Berk, B; Robison, RS | 1 |
| van der Drift, C; Vogels, GD | 1 |
| Barrio, A; Carlisky, NJ | 1 |
| Bernlohr, RW; Renner, ED | 1 |
| Kleppe, K; Spaeren, U | 1 |
| Dunkl, H; Kraft-Kinz, J; List, WF | 1 |
| Bosmann, HB; Hemsworth, BA | 1 |
| D'Mello, JP; Lewis, D | 1 |
| Echandi, RJ; Massey, LM | 1 |
| Porembska, Z; Swiatkowska, B; Szymczyk, T | 1 |
| Brunner, CE; Bryan, JK; Bryan, PA; Cawley, RD | 1 |
| Entlicher, G; Kocourek, J; Kostír, JV; Tichá, M | 1 |
| Chan, TM; Freedland, RA | 1 |
| Steenbergen, ST; Weinberg, ED | 1 |
| Palacios, R; Soberón, G; Tarrab, R | 1 |
| Barrio, A; Botbol, V; Carlisky, NJ; García Argiz, CA; Lew, VL | 1 |
| Mankovitz, R; Segal, HL | 1 |
| Nair, PM | 1 |
| Chibata, I; Kakimoto, T; Kato, J; Nishimura, N; Shibatani, T | 1 |
| Bright, HJ | 1 |
| Kneer, N; Lardy, HA; Veneziale, CM; Walter, P | 1 |
| Hubbard, JS; Stadtman, ER | 1 |
| Heinemann, U; Louvel, J; Marciani, MG | 1 |
| Dale, N; Roberts, A | 1 |
| Khazaeli, S; Viola, RE | 1 |
| Chen, CY; Cook, PF; Hermes, JD; Nuiry, II; Weiss, PM | 1 |
| Reuter, HD; Schröter, G | 1 |
| Heinemann, U; Pumain, R | 1 |
| He, MM; Hubbell, WL; Kaback, HR; Voss, J | 1 |
| Ariyoshi, M; Iwasaki, H; Morikawa, K; Saito, A; Shinagawa, H | 1 |
| Behravan, G; Goodtzova, K; Gräslund, A; Ingemarson, R; Rova, U; Thelander, L | 1 |
| Chu, HA; Debus, RJ; Nguyen, AP | 4 |
| Chang, GG; Chou, WY; Wei, CH | 1 |
| Alibhai, M; Villafranca, JJ | 1 |
| Baker, TA; Luo, L | 1 |
| Burnap, RL; Inoue, Y; Qian, M; Shen, JR; Sherman, LA | 1 |
| Chang, GG; Chou, WY; Huang, SM; Lin, CC; Wei, CH | 1 |
| Copeland, WC; Wang, TS | 1 |
| Eaton, SS; Osumi-Davis, PA; Woody, AY; Woody, RW | 1 |
| Gold, MH; Kishi, K; Kusters-van Someren, M; Loehr, TM; Mayfield, MB; Sun, J | 1 |
| Jongewaard, IN; Smith, JW; Tsai, PM | 1 |
| Cane, DE; Fitzsimons, BC; Xue, Q | 1 |
| Babcock, GT; Ferguson-Miller, S; Hoganson, C; Mills, D; Pressler, M; Qian, J; Shi, W | 1 |
| Miziorko, HM; Roberts, JR | 1 |
| Bill, E; Kolbesen, BO; Ludwig, B; Witt, H; Wittershagen, A | 1 |
| Hazell, AS; Norenberg, MD | 1 |
| Cheng, K; Koland, JG | 1 |
| Cladera, J; Duñach, M; Labarta, A; Padrós, E; Pardo, L; Sepulcre, F; Tejada, J | 1 |
| Ghirardi, ML; Lutton, TW; Seibert, M | 1 |
| Blanco, L; Lázaro, JM; Salas, M; Saturno, J | 1 |
| Eliash, T; Ottolenghi, M; Sheves, M | 1 |
| Gilman, AG; Gosselin, G; Johnson, RA; Sprang, SR; Sunahara, RK; Tesmer, JJ | 1 |
| Inoue, T; Izui, K; Kai, Y; Matsumura, H; Shirakata, S; Terada, M; Yoshinaga, T | 1 |
| Dai, Y; Kim, DR; Mundy, CL; Oettinger, MA; Yang, W | 1 |
| Harris, TK; Massiah, MA; Mildvan, AS; Wu, G | 1 |
| Chang, GG; Chang, HP; Chou, WY; Huang, CH; Kuo, CC; Tong, L | 1 |
| Mandal, D; Rao, R; Woolf, TB | 1 |
| Goedken, ER; Marqusee, S | 1 |
| Pingoud, A; Pingoud, V; Schöttler, S; Wende, W | 1 |
| Janulaitis, A; Rimseliene, R | 1 |
| Nicholson, AW; Sun, W | 1 |
| Gold, MH; Li, D; Sollewijn Gelpke, MD; Sundaramoorthy, M; Youngs, HL | 1 |
| Hattori, H; Ise, F; Sekiguchi, J; Shida, T | 1 |
| Liu, J; Tsai, MD | 1 |
| Bowman, ME; Cane, DE; Ferrer, JL; Lillo, AM; Noel, JP; Richard, SB; Tetzlaff, CN | 1 |
| Ananthnarayan, V; Horton, NC; Kohn, J; Lusetti, S; Martin, AM; Otey, C; Perona, JJ; Sam, MD | 1 |
| Gong, D; Guo, Y; Jagendorf, AT; Zhu, JK | 1 |
| Carvajal, N; López, N; López, V; Rodríguez, R; Salas, M; Uribe, E | 1 |
| Aschner, M; Erikson, K | 1 |
| Haruki, M; Kanaya, S; Morikawa, M; Oobatake, M; Tsunaka, Y | 1 |
| Izui, K; Kai, Y; Matsumura, H | 1 |
| Chang, GG; Chen, YH; Chen, YI; Chou, WY | 1 |
| Barry, BA; Halverson, KM; Sachs, RK | 1 |
| Aznar, C; Britt, RD; Campbell, KA; Debus, RJ; Diner, BA; Gregor, W | 1 |
| DECONNINCK, G; VOETS, JP | 1 |
| SELBIN, J; WILLIAMS, VR | 1 |
| BURCHALL, JJ; REICHELT, EC; WOLIN, MJ | 1 |
| Colman, RF; Grodsky, NB; Huang, YC; Kim, TK | 1 |
| Arrowsmith, CH; Brown, G; Edwards, AM; Kuznetsova, E; Proudfoot, M; Savchenko, A; Yakunin, AF | 1 |
| Holthuizen, PE; Mysiak, ME; van der Vliet, PC | 1 |
| Kirsebom, LA; Ren, YG; Virtanen, A | 1 |
| Li, G; Nicholson, AW; Sun, W | 1 |
| Etzkorn, C; Horton, NC | 1 |
| Cellier, MF; Chaloupka, R; Courville, P; Knudsen, B; Tompkins, TA; Veyrier, F | 1 |
| Binkowski, DJ; Fromm, HJ; Honzatko, RB; Nelson, SW | 1 |
| Kanaya, S; Matsumura, H; Takano, K; Tsunaka, Y; Yamagata, Y | 1 |
| Bibillo, A; Klarmann, GJ; Le Grice, SF; Lener, D | 1 |
| Debus, RJ; Hillier, W; Strickler, MA; Walker, LM | 1 |
| Cohen, SM; Davis, TC; Golynskiy, MV; Helmann, JD | 1 |
| Dahms, NM; Kalyanaraman, B; Sun, G; Zhao, H | 1 |
| An, XM; Chang, WR; Li, HT; Li, M; Liu, MC; Lu, JH; Zhang, JP | 1 |
| Colman, RF; Fomulu, KS; O'Hagan, M; Soundar, S | 1 |
| Gajjar, MM; Kapoor, A; Kuruvilla, SM; Lasker, MV; Nair, SK | 1 |
| Cheong, HK; Choi, DS; Kang, DM; Kim, EA; Park, I; Ryoo, JW; Sakong, J | 1 |
| Ishii, R; Minagawa, A; Nashimoto, M; Takagi, M; Takaku, H; Yokoyama, S | 1 |
| Barker, PB; Chen, MK; Degaonkar, M; Guilarte, TR; McGlothan, JL; Schneider, JS; Syversen, T | 1 |
| Britt, RD; Debus, RJ; Hillier, W; Strickler, MA; Walker, LM | 1 |
| Altrock, WD; Angenstein, F; Gundelfinger, ED; Hilfert, L; Niessen, HG; Zuschratter, W | 1 |
| Holm, DA; Madsen, KS; Rowland, IJ; Søgaard, LV | 1 |
| Kang, TG; Wang, P; Xu, J | 1 |
| Elbarbary, RA; Nashimoto, M; Takaku, H | 1 |
| Roos, K; Siegbahn, PE | 1 |
| Burton, NC; Guilarte, TR | 1 |
| Ahn, HJ; Ahn, JH; Chang, Y; Chung, IS; Jeong, KS; Kim, SH; Kim, Y; Kwon, YJ; Lee, H; Lee, HJ; Lee, JJ; Park, SJ; Song, HJ; Weon, YC; Woo, ST; Yoo, DS | 1 |
| Commet, A; Popelkova, H; Yocum, CF | 1 |
| Fujishima, K; Kanai, A; Kitamura, S; Sato, A; Tomita, M; Tsuchiya, D | 1 |
| Bax, BD; Brown, KK; Chan, PF; Eggleston, DS; Fosberry, A; Gentry, DR; Giordano, I; Gorrec, F; Gwynn, MN; Hann, MM; Hennessy, A; Hibbs, M; Huang, J; Jones, E; Jones, J; Lewis, CJ; May, EW; Pearson, ND; Saunders, MR; Shen, C; Shillings, A; Singh, O; Spitzfaden, CE; Theobald, AJ; Wohlkonig, A | 1 |
| Britt, RD; Debus, RJ; Service, RJ; Stich, TA; Yeagle, GJ | 1 |
| Aschner, M; Criswell, SR; Dydak, U; Guilarte, TR; Racette, BA; Zheng, W | 1 |
| Kamboj, SS; Kaur, N; Singh, J | 1 |
| Cogdell, RJ; Grinter, R; Milner, JJ; Roszak, AW; Walker, D | 1 |
| Alam, M; Deep, S; Meena, SK; Nayeem, SM; Sau, AK; Srivastava, A | 1 |
| Bearer, EL; Gallagher, JJ; Hall, FS; Jacobs, RE; Uhl, GR; Zhang, X | 1 |
| Angerhofer, A; Grant, M; Hoffer, E; Immelman, B; Moomaw, EW; Moussatche, P; Ozarowski, A; Salerno, JC; Uberto, R | 1 |
| Appella, E; Debnath, S; Durell, SR; Ishida, K; Mazur, SJ; Miller Jenkins, LM; Sakai, H; Tagad, HD; Tanoue, K | 1 |
| Kanaya, S; Tannous, E | 1 |
| Bailey, TD; Johnson, AJ; Kersaitis, C; Lennon, BR; O'Doherty, PJ; Petersingham, G; Tun, NM; Wu, MJ | 1 |
| Frankcombe, T; Pace, R; Stranger, R; Terrett, R | 1 |
| Dangott, L; Mertsalov, IB; Novikov, BN; Panin, VM; Scott, H | 1 |
| Chávez, JC; Garza-López, E; López-González, I; Nishigaki, T; Santana-Calvo, C | 1 |
| Gross, ML; Pakrasi, HB; Weisz, DA | 1 |
| Carl, A; Goldgur, Y; Shuman, S; Uson, ML | 1 |
| Escalante, M; Hernández-Kelly, LC; Hernández-Melchor, D; López-Bayghen, E; Olivares-Bañuelos, TN; Ortega, A; Soto-Verdugo, J | 1 |
| Fang, F; He, R; Li, R; Wang, X | 1 |
| Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY | 1 |
2 review(s) available for aspartic acid and manganese
| Article | Year |
|---|---|
Phosphoenolpyruvate carboxylase: three-dimensional structure and molecular mechanisms.
Topics: Allosteric Site; Amino Acid Sequence; Amino Acids; Aspartic Acid; Catalytic Domain; Crystallography, X-Ray; Dimerization; Escherichia coli; Manganese; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoenolpyruvate Carboxylase; Phosphorylation; Protein Binding; Protein Conformation; RNA; Sequence Homology, Amino Acid; Zea mays | 2003 |
Manganese neurotoxicity: lessons learned from longitudinal studies in nonhuman primates.
Topics: Animals; Aspartic Acid; Cognition; Creatine; Environmental Exposure; Glutamate-Ammonia Ligase; Kinetics; Manganese; Mitochondria; Motor Activity; Nervous System; Neurotransmitter Agents; Oxidative Stress; Primates; Synapses | 2009 |
1 trial(s) available for aspartic acid and manganese
| Article | Year |
|---|---|
[Metabolic changes during anesthesia in intracardial operations].
Topics: Acid-Base Equilibrium; Acidosis; Anesthesia; Aspartic Acid; Benperidol; Blood Circulation; Child; Ductus Arteriosus, Patent; Heart Defects, Congenital; Heart Septal Defects, Atrial; Humans; Hypothermia, Induced; Manganese; Mitral Valve Insufficiency; Neuroleptanalgesia; Potassium; Tetralogy of Fallot; Trimethaphan | 1969 |
156 other study(ies) available for aspartic acid and manganese
| Article | Year |
|---|---|
Some properties of the pyruvate carboxylase from Pseudomonas fluorescens.
Topics: Acetyl Coenzyme A; Adenosine Diphosphate; Adenosine Triphosphate; Aspartic Acid; Avidin; Biotin; Enzyme Activation; Glucose; Hydrogen-Ion Concentration; Magnesium; Manganese; Molecular Weight; Pseudomonas fluorescens; Pyruvate Carboxylase; Pyruvates; Temperature | 1976 |
Carboxylation of phosphoenolpyruvate by extracts of Neisseria gonorrhoeae.
Topics: Adenosine Diphosphate; Aspartic Acid; Bicarbonates; Cell-Free System; Fructosephosphates; Fumarates; Guanine Nucleotides; Hydrogen-Ion Concentration; Inosine Nucleotides; Magnesium; Malates; Manganese; Neisseria gonorrhoeae; Phosphoenolpyruvate; Temperature | 1977 |
Binding of substrate analogues to hen egg-white lysozyme with 2-nitrophenylsulfenylated tryptophan 62.
Topics: Acetylglucosamine; Animals; Aspartic Acid; Binding Sites; Chickens; Circular Dichroism; Cobalt; Egg White; Glucosamine; Glutamates; Hydrogen-Ion Concentration; Manganese; Muramidase; Nitrobenzenes; Osmolar Concentration; Protein Binding; Protein Conformation; Sulfenic Acids; Tryptophan | 1975 |
Commitment to sporulation in Bacillus megaterium and uptake of specific compounds.
Topics: Amino Acids; Aspartic Acid; Bacillus megaterium; Carbohydrate Metabolism; Caseins; Fructose; Glucose; Glutamates; Glycerol; Manganese; Spores, Bacterial; Sucrose | 1976 |
Evidence from directed mutagenesis that aspartate 170 of the D1 polypeptide influences the assembly and/or stability of the manganese cluster in the photosynthetic water-splitting complex.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Chlorophyll; Chlorophyll A; Cyanobacteria; Diuron; Drug Stability; Electron Spin Resonance Spectroscopy; Kinetics; Light-Harvesting Protein Complexes; Macromolecular Substances; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Photosynthesis; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Restriction Mapping; Spectrometry, Fluorescence | 1992 |
Mutational analysis of pea lectin. Substitution of Asn125 for Asp in the monosaccharide-binding site eliminates mannose/glucose-binding activity.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Binding Sites; Calcium; DNA Mutational Analysis; Escherichia coli; Fabaceae; Glucose; Lectins; Manganese; Mannose; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phytohemagglutinins; Plant Lectins; Plants, Medicinal; Sequence Alignment; Structure-Activity Relationship | 1992 |
Extracellular alkaline-acid pH shifts evoked by iontophoresis of glutamate and aspartate in turtle cerebellum.
Topics: Animals; Aspartic Acid; Bicarbonates; Cadmium; Calcium Channel Blockers; Cerebellum; Electric Stimulation; Extracellular Space; Female; Glutamates; Glutamic Acid; HEPES; Hydrogen-Ion Concentration; Ion Channel Gating; Ion Channels; Iontophoresis; Male; Manganese; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Turtles | 1991 |
Aspartate 170 of the photosystem II reaction center polypeptide D1 is involved in the assembly of the oxygen-evolving manganese cluster.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Cyanobacteria; Kinetics; Manganese; Mutagenesis, Site-Directed; Oxygen; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Recombinant Proteins; Serine; Spectrometry, Fluorescence | 1992 |
Glutamate- and aspartate-induced extracellular potassium and calcium shifts and their relation to those of kainate, quisqualate and N-methyl-D-aspartate in the isolated turtle cerebellum.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cerebellum; Dose-Response Relationship, Drug; Extracellular Space; Glutamates; Glutamic Acid; In Vitro Techniques; Iontophoresis; Kainic Acid; Manganese; N-Methylaspartate; Potassium; Quisqualic Acid; Turtles | 1990 |
Divalent cation binding to reduced and octanoyl acyl-carrier protein.
Topics: Acyl Carrier Protein; Aspartic Acid; Binding Sites; Binding, Competitive; Calcium; Cations, Divalent; Electron Spin Resonance Spectroscopy; Escherichia coli; Glutamates; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Manganese; Oxidation-Reduction; Protein Conformation; Sodium Chloride | 1990 |
Some properties of ionic channels activated by excitatory amino acids in hippocampal neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Electric Conductivity; Electric Stimulation; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Homocysteine; In Vitro Techniques; Ion Channels; Manganese; Oxadiazoles; Quisqualic Acid | 1985 |
Action of excitatory amino acids and their antagonists on hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Guinea Pigs; Hippocampus; Iontophoresis; Manganese; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Tetrodotoxin; Valine | 1985 |
Synergistic inhibition of phosphoenolpyruvate carboxylase by aspartate and 2-oxoglutarate in Brevibacterium flavum.
Topics: Aspartic Acid; Bacterial Proteins; Brevibacterium; Carboxy-Lyases; Drug Synergism; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kinetics; Magnesium; Malates; Manganese; Phosphoenolpyruvate Carboxylase; Structure-Activity Relationship; Succinates; Succinic Acid | 1985 |
A glutamyl residue in the active site of triphosphopyridine nucleotide-dependent isocitrate dehydrogenase of pig heart.
Topics: Amides; Animals; Aspartic Acid; Binding Sites; Carbodiimides; Carbon Radioisotopes; Carboxy-Lyases; Catalysis; Cysteine; Drug Synergism; Glutamates; Glycine; Isocitrate Dehydrogenase; Isocitrates; Ketoglutaric Acids; Kinetics; Manganese; Morpholines; Myocardium; NADP; Swine; Temperature; Tyrosine | 1973 |
NAD malic enzyme in leaves with C-pathway photosynthesis and its role in C4 acid decarboxylation.
Topics: Acetyl Coenzyme A; Aspartate Aminotransferases; Aspartic Acid; Catalase; Centrifugation, Density Gradient; Chlorophyll; Fumarate Hydratase; Magnesium; Malate Dehydrogenase; Malates; Manganese; NAD; NADP; Photosynthesis; Plants; Species Specificity; Spectrophotometry, Ultraviolet; Sulfates | 1974 |
Immobilized aspartase-containing microbial cells: preparation and enzymatic properties.
Topics: Acrylamides; Ammonia-Lyases; Aspartic Acid; Autolysis; Bacteriological Techniques; Bacteriolysis; Bacteroides; Enzyme Activation; Escherichia coli; Fumarates; Glutaral; Hydrogen-Ion Concentration; Indicators and Reagents; Manganese; Microscopy, Electron, Scanning; Proteus vulgaris; Pseudomonas aeruginosa; Quaternary Ammonium Compounds; Serratia marcescens; Temperature | 1974 |
Chromatographic separation on silica gel glass fiber paper of compounds from yeast labeled by aspartate-14C.
Topics: Aspartic Acid; Carbon Isotopes; Chromatography, Paper; Cyanides; Glass; Glutamates; Manganese; Mutation; Orotic Acid; Phenols; Saccharomyces; Silicon Dioxide; Succinates | 1967 |
Carbon dioxide fixation and phosphoenolpyruvate carboxylase in Ferrobacillus ferrooxidans.
Topics: Adenosine Triphosphate; Aspartic Acid; Bacteria; Carbon Dioxide; Carbon Isotopes; Carboxy-Lyases; Cell-Free System; Citrates; Coenzyme A; Glutamates; Hydrogen-Ion Concentration; Ketoglutaric Acids; Lyases; Magnesium; Malate Dehydrogenase; Malates; Manganese; NAD; Phosphates; Pyruvates; Spectrophotometry; Succinates; Threonine | 1967 |
Asparagine biosynthesis by the Novikoff Hepatoma isolation, purification, property, and mechanism studies of the enzyme system.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Ammonium Chloride; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Carcinoma, Hepatocellular; Diphosphates; Female; Glutamine; Hydrogen-Ion Concentration; Hydroxamic Acids; Hydroxylamines; Liver Neoplasms; Magnesium; Manganese; Neoplasms, Experimental; Potassium; Rats | 1968 |
Magnetic resonance and kinetic studie of the activation of beta-methylaspartase by manganese.
Topics: Aspartic Acid; Binding Sites; Chemical Phenomena; Chemistry; Electron Spin Resonance Spectroscopy; Enzyme Activation; Fumarates; Hydrogen-Ion Concentration; Kinetics; Lyases; Magnetic Resonance Spectroscopy; Manganese; Models, Chemical; Potassium; Protein Binding; Protons | 1970 |
Magnetic resonance study of the Mn 2+ --lysozyme complex.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Chlorides; Cobalt; Electron Spin Resonance Spectroscopy; Glutamates; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Manganese; Muramidase; Nitrogen; Oxygen; Protons; Quaternary Ammonium Compounds; Tromethamine; Water | 1971 |
A soluble aspartate aminopeptidase from dog kidney.
Topics: Amides; Aminopeptidases; Ammonium Sulfate; Angiotensin II; Animals; Aspartic Acid; Calcium Chloride; Chemical Precipitation; Chlorides; Chromatography, DEAE-Cellulose; Chromatography, Gel; Dogs; Edetic Acid; Endopeptidases; Enzyme Activation; Glutamates; Kidney; Manganese; Microsomes; Naphthalenes; Solubility | 1971 |
Threonine-sensitive aspartokinase from Escherichia coli. Magnetic resonance and binding studies.
Topics: Adenosine Triphosphate; Alcohol Oxidoreductases; Aspartic Acid; Binding Sites; Binding, Competitive; Electron Spin Resonance Spectroscopy; Escherichia coli; Homoserine; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Manganese; Mathematics; Multienzyme Complexes; Phosphorus Radioisotopes; Phosphotransferases; Protein Binding; Radioisotopes; Spectrophotometry, Atomic; Threonine; Ultrafiltration | 1973 |
The kinetics of NAD-linked isocitrate dehydrogenase from calf heart.
Topics: Adenosine Diphosphate; Animals; Aspartic Acid; Binding Sites; Calorimetry; Cattle; Glutamates; Hydrogen-Ion Concentration; Isocitrate Dehydrogenase; Isocitrates; Kinetics; Manganese; Mathematics; Myocardium; NAD; Protein Binding; Spectrophotometry, Ultraviolet; Temperature; Thermodynamics | 1974 |
Cooperative interactions in the binding of allosteric effectors to phosphoenolpyruvate carboxylase.
Topics: Acetyl Coenzyme A; Allosteric Regulation; Amino Acid Sequence; Aspartic Acid; Binding Sites; Carbon Radioisotopes; Carboxy-Lyases; Chromatography, Gel; Dansyl Compounds; Electrophoresis, Polyacrylamide Gel; Guanidines; Guanosine Triphosphate; Kinetics; Magnesium; Manganese; Molecular Weight; Peptide Fragments; Phosphates; Phosphoenolpyruvate; Protein Binding; Salmonella typhimurium; Sodium Dodecyl Sulfate; Spectrophotometry, Ultraviolet; Sulfur Radioisotopes; Ultracentrifugation | 1974 |
Basic studies for continuous production of L-aspartic acid by immobilized Escherichia coli cells.
Topics: Acrylamides; Aspartic Acid; Bacteriological Techniques; Biological Assay; Calcium; Escherichia coli; Fumarates; Gels; Hydrogen-Ion Concentration; Leuconostoc; Magnesium; Manganese; Quaternary Ammonium Compounds; Stereoisomerism; Temperature | 1974 |
Studies on plant aspartate transcarbamylase. Purification and properties of the enzyme from mung-bean (Phaseolus aureus) seedlings.
Topics: Allosteric Regulation; Ammonium Sulfate; Aspartate Carbamoyltransferase; Aspartic Acid; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Electrophoresis, Disc; Escherichia coli; Feedback; Hot Temperature; Hydrogen-Ion Concentration; Hydroxymercuribenzoates; Kinetics; Manganese; Molecular Weight; Organophosphorus Compounds; Plants; Seeds; Ultracentrifugation; Uracil Nucleotides | 1974 |
Partial purification and characterization of an aspartate racemase from Streptococcus faecalis.
Topics: Alanine; Aluminum Hydroxide; Amino Acid Isomerases; Ammonium Sulfate; Aspartic Acid; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Dithiothreitol; Drug Stability; Enterococcus faecalis; Glutamates; Hot Temperature; Hydrogen-Ion Concentration; Hydroxylamines; Isomerases; Kinetics; Ligases; Manganese; Structure-Activity Relationship; Sulfhydryl Reagents | 1972 |
Structure of concanavalin A at 2.4-A resolution.
Topics: Acetates; Amino Acids; Aspartic Acid; Binding Sites; Calcium; Carbohydrates; Chemical Phenomena; Chemistry; Chlorides; Concanavalin A; Lectins; Ligands; Macromolecular Substances; Manganese; Mercury; Methylmercury Compounds; Models, Chemical; Models, Structural; Peptides; Phenols; Platinum; Protein Conformation; X-Ray Diffraction | 1972 |
Studies of parameters affecting the allosteric nature of phosphoenolpyruvate carboxylase of Escherichia coli.
Topics: Aspartic Acid; Binding Sites; Carboxy-Lyases; Coenzyme A; Dioxins; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Magnesium; Malates; Manganese; Succinates | 1968 |
L-asparaginase synthesis by Escherichia coli B.
Topics: Asparaginase; Asparagine; Aspartic Acid; Copper; Culture Media; Escherichia coli; Glucose; Glutamine; Glycerol; Iron; Manganese; Monosaccharides; Temperature; Zinc | 1969 |
Allantoate amidohydrolase. I. pH- and anion-dependent activation.
Topics: Acetates; Allantoin; Amidohydrolases; Aspartic Acid; Binding Sites; Citrates; Edetic Acid; Glutarates; Hydantoins; Hydrogen-Ion Concentration; Kinetics; Malates; Maleates; Manganese; Oxalates; Phosphates; Streptococcus; Succinates; Tartrates | 1969 |
Nitrogen metabolism of the South American lungfish Lepidosiren paradoxa.
Topics: Acetates; Ammonia; Animals; Arginine; Aspartic Acid; Bicarbonates; Carbon Isotopes; Citrulline; Climate; Fasting; Fishes; Glutamates; Guanidines; Leucine; Liver; Manganese; Ornithine; Serine; Stereoisomerism; Urea | 1972 |
Characterization and regulation of pyruvate carboxylase of Bacillus licheniformis.
Topics: Adenosine Triphosphate; Aspartic Acid; Bacillus; Bicarbonates; Biotin; Carbon Dioxide; Coenzyme A; Enzyme Repression; Glucose; Glycerol; Ligases; Malates; Manganese; Ovalbumin; Oxaloacetates; Peptones; Phosphoenolpyruvate; Pyruvate Kinase; Pyruvates; Spores, Bacterial | 1972 |
Aspartate transcarbamylase from Escherichia coli. II. Interaction of metal ions with substrates, inhibitors and activators.
Topics: Adenosine Triphosphate; Aspartic Acid; Cadmium; Chemical Phenomena; Chemistry; Cobalt; Copper; Cytosine Nucleotides; Enzymes; Escherichia coli; Magnesium; Manganese; Nickel; Transferases; Zinc | 1966 |
Intraneural mitochondria. Incorporation of amino acids and monosaccharides into macromolecules by isolated synaptosomes and synaptosomal mitochondria.
Topics: Amino Acids; Animals; Aspartic Acid; Carbon Isotopes; Cerebral Cortex; Chloramphenicol; Cycloheximide; Depression, Chemical; Glucosamine; Glycine; Glycolipids; Glycoproteins; Guinea Pigs; Hexoses; Hydrolases; In Vitro Techniques; Leucine; Lipids; Male; Manganese; Methods; Mitochondria; Monoamine Oxidase; Nerve Tissue; Nerve Tissue Proteins; Nucleotides; Pentoses; Ribonucleases; Succinate Dehydrogenase; Synapses; Temperature; Time Factors | 1970 |
Amino acid interactions in chick nutrition. 1. The interrelationship between lysine and arginine.
Topics: Amino Acids; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Arginine; Aspartic Acid; Body Weight; Chickens; Cobalt; Copper; Electrolytes; Female; Glutamates; Histidine; Isoleucine; Leucine; Lysine; Manganese; Molybdenum; Nutritional Requirements; Phenylalanine; Selenium; Threonine; Tyrosine; Vitamins; Zinc | 1970 |
Loss of electrolytes and amino acids from gamma-irradiated carrots.
Topics: Aluminum; Amino Acids; Aspartic Acid; Boron; Calcium; Cell Membrane Permeability; Copper; Electrolytes; Food Irradiation; Iron; Manganese; Phosphorus; Radiometry; Sodium; Vegetables; Zinc | 1970 |
Studies on the origin of urea in submaxillary and sublingual glands of the rat.
Topics: Animals; Arginase; Aspartic Acid; Butyrates; Cell Nucleus; Citrulline; Enzyme Activation; Guanidines; Hot Temperature; Hydrogen-Ion Concentration; Ligases; Lyases; Manganese; Mitochondria; Ornithine Carbamoyltransferase; Proteins; Rats; Sublingual Gland; Submandibular Gland; Succinates; Urea; Ureohydrolases | 1970 |
Isolation and characterization of a lysine-sensitive aspartokinase from a multicellular plant.
Topics: Adenosine Triphosphate; Alanine; Aspartic Acid; Enzyme Activation; Isoleucine; Kinetics; Leucine; Lysine; Magnesium; Manganese; Methionine; Phosphotransferases; Plants; Threonine; Valine; Zea mays | 1970 |
Studies on phytohemagglutinins. IV. Isolation and characterization of a hemagglutinin from the lentil, Lens, esculenta, Moench.
Topics: Aspartic Acid; Calcium; Carbohydrates; Chemical Precipitation; Chromatography, Gel; Electrophoresis; Electrophoresis, Disc; Hemagglutination Tests; Humans; Hydrogen-Ion Concentration; Lectins; Manganese; Molecular Weight; Plant Lectins; Plants; Quaternary Ammonium Compounds; Sulfates; Threonine; Ultracentrifugation | 1970 |
The role of L-serine dehydratase in the metabolism of L-serine in the perfused rat liver.
Topics: Animals; Aspartic Acid; Carboxy-Lyases; Chlorides; Freezing; Gluconeogenesis; Glutamates; Hydro-Lyases; L-Serine Dehydratase; Lactates; Liver; Malates; Male; Manganese; Oxaloacetates; Perfusion; Phosphoric Acids; Pyridines; Pyruvates; Rats; Serine; Starvation | 1971 |
Trace metal requirements for malformin biosynthesis.
Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Arginine; Aspartic Acid; Aspergillus; Chromium; Cobalt; Copper; Cysteine; Glutamine; Glycine; Histidine; Iron; Isoleucine; Leucine; Lysine; Manganese; Metals; Molybdenum; Peptide Biosynthesis; Phenylalanine; Plant Growth Regulators; Proline; Serine; Trace Elements; Tryptophan; Tyrosine; Valine; Zinc | 1968 |
Studies on the advent of ureotelism. Factors that render the hepatic arginase of the Mexican axolotl able to hydrolyse endogenous arginine.
Topics: Animals; Arginase; Arginine; Aspartic Acid; Citrulline; Liver; Manganese; Metamorphosis, Biological; Urodela | 1968 |
Properties and subcellular distribution of ornithine cycle enzymes in amphibian kidney.
Topics: Animals; Anura; Arginase; Arginine; Aspartic Acid; Canavanine; Dinitrophenols; Enzyme Activation; Female; Hydrogen-Ion Concentration; Kidney; Kidney Tubules; Kinetics; Leucine; Ligases; Liver; Lyases; Male; Manganese; Microsomes; Molecular Weight; Ornithine; Ornithine Carbamoyltransferase; Phosphotransferases; Potassium Chloride; Succinates; Urea | 1968 |
Dissociation-produced loss of regulatory control of homoserine dehydrogenase of Rhodospirillum rubrum. I. Factors which affect the interconversion of the regulatable and nonregulatable states.
Topics: Acetates; Adenosine Triphosphate; Alcohol Oxidoreductases; Aldehydes; Amino Acids; Aspartic Acid; Binding Sites; Calcium; Centrifugation; Chemical Phenomena; Chemical Precipitation; Chemistry; Chlorine; Feedback; Magnesium; Manganese; Methods; Models, Chemical; Osmolar Concentration; Protamines; Quaternary Ammonium Compounds; Rhodospirillum; Threonine; Time Factors; Vibration | 1969 |
Asparagine synthetase from gamma-irradiated potatoes.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Asparagine; Aspartic Acid; Carbon Isotopes; Chemical Precipitation; Chromatography, Gel; Food Irradiation; Hydrogen-Ion Concentration; Hydroxylamines; Kinetics; Ligases; Magnesium; Manganese; Methods; Phosphates; Plants; Quaternary Ammonium Compounds; Radiation Effects; Transferases; Vegetables | 1969 |
Crystalline aspartic beta-decarboxylase of Pseudomonas dacunhae.
Topics: Aluminum; Aspartic Acid; Carboxy-Lyases; Cobalt; Crystallography; Iron; Ketoglutaric Acids; Manganese; Nickel; Pseudomonas; Pyridoxal Phosphate | 1967 |
Divalent metal activation of beta-methylaspartase. The importance of ionic radius.
Topics: Aspartic Acid; Calcium; Chemical Phenomena; Chemistry; Clostridium; Cobalt; Fumarates; Kinetics; Lyases; Magnesium; Manganese; Metals; Potassium; Strontium | 1967 |
Influence of L-tryptophan and its metabolites on gluconeogenesis in the isolated, perfused liver.
Topics: Alanine; Animals; Aspartic Acid; Blood Glucose; Caprylates; Carboxy-Lyases; Fatty Acids; Gluconeogenesis; Lactates; Liver; Malates; Male; Manganese; Oxaloacetates; Perfusion; Pyruvates; Quinolines; Rats; Tryptophan | 1967 |
Regulation of glutamine synthetase. V. Partial purification and properties of glutamine synthetase from Bacillus licheniformis.
Topics: Acyltransferases; Adenine Nucleotides; Ammonium Chloride; Aspartic Acid; Bacillus; Centrifugation, Density Gradient; Cytosine Nucleotides; Electrophoresis; Glutamates; Glutamine; Guanine Nucleotides; Hydroxamic Acids; Ligases; Magnesium; Manganese; Nucleotides; Pyruvate Kinase; Pyruvates; Uracil Nucleotides | 1967 |
Conductance changes induced by DL-homocysteic acid and N-methyl-DL-aspartic acid in hippocampal neurons.
Topics: Animals; Aspartic Acid; Cell Membrane; Electric Conductivity; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Homocysteine; In Vitro Techniques; Iontophoresis; Manganese; N-Methylaspartate; Tetrodotoxin | 1982 |
Aspartate-induced changes in extracellular free calcium in 'in vitro' hippocampal slices of rats.
Topics: Animals; Aspartic Acid; Calcium; Culture Techniques; Extracellular Space; gamma-Aminobutyric Acid; Hippocampus; Ion Channels; Magnesium; Manganese; Membrane Potentials; Nickel; Rats; Tetrodotoxin | 1982 |
Excitatory amino acid receptors in Xenopus embryo spinal cord and their role in the activation of swimming.
Topics: Animals; Aspartic Acid; Kainic Acid; Manganese; Membrane Potentials; Motor Activity; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Swimming; Xenopus | 1984 |
A multinuclear NMR relaxation study of the interaction of divalent metal ions with L-aspartic acid.
Topics: Alanine; Aspartic Acid; Cations, Divalent; Chemical Phenomena; Chemistry; Copper; Magnesium; Magnetic Resonance Spectroscopy; Manganese; Phosphoserine; Solutions | 1984 |
Kinetic mechanism and location of rate-determining steps for aspartase from Hafnia alvei.
Topics: Ammonia; Ammonia-Lyases; Aspartate Ammonia-Lyase; Aspartic Acid; Enterobacteriaceae; Fumarates; Kinetics; Magnesium; Manganese; Mathematics | 1984 |
[Potassium, magnesium, copper, manganese and cobalt salts of aspartic acid on platelet factor 3 availability (author's transl)].
Topics: Aspartic Acid; Blood Coagulation Factors; Cobalt; Copper; Humans; Magnesium; Manganese; Platelet Aggregation; Platelet Factor 3; Potassium | 1980 |
Extracellular calcium activity changes in cat sensorimotor cortex induced by iontophoretic application of aminoacids.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Calcium; Cats; Cerebral Cortex; Cobalt; gamma-Aminobutyric Acid; Glutamates; Homocysteine; Lanthanum; Manganese | 1980 |
Use of designed metal-binding sites to study helix proximity in the lactose permease of Escherichia coli. 1. Proximity of helix VII (Asp237 and Asp240) with helices X (Lys319) and XI (Lys358).
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Biological Transport, Active; Cloning, Molecular; Escherichia coli Proteins; Hydrogen-Ion Concentration; Lysine; Manganese; Membrane Transport Proteins; Molecular Sequence Data; Monosaccharide Transport Proteins; Protein Structure, Secondary; Symporters | 1995 |
Identification of four acidic amino acids that constitute the catalytic center of the RuvC Holliday junction resolvase.
Topics: Aspartic Acid; Bacterial Proteins; Base Sequence; Binding Sites; Catalysis; DNA, Bacterial; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Genetic Complementation Test; Glutamic Acid; Magnesium; Manganese; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenotype; Protein Conformation; Recombination, Genetic; Ribonuclease H | 1995 |
Evidence by site-directed mutagenesis supports long-range electron transfer in mouse ribonucleotide reductase.
Topics: Alanine; Animals; Aspartic Acid; Base Sequence; Binding Sites; Electron Transport; Free Radicals; Hydrogen Bonding; Macromolecular Substances; Manganese; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Recombinant Proteins; Ribonucleotide Reductases; Structure-Activity Relationship; Tryptophan; Tyrosine | 1995 |
Amino acid residues that influence the binding of manganese or calcium to photosystem II. 1. The lumenal interhelical domains of the D1 polypeptide.
Topics: Amino Acids; Aspartic Acid; Calcium; Cyanobacteria; Electron Transport; Glutamic Acid; Histidine; Light; Light-Harvesting Protein Complexes; Manganese; Mutagenesis, Site-Directed; Photochemistry; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Plastoquinone; Protein Structure, Secondary; Spectrometry, Fluorescence; Structure-Activity Relationship; Tyrosine | 1995 |
Amino acid residues that influence the binding of manganese or calcium to photosystem II. 2. The carboxy-terminal domain of the D1 polypeptide.
Topics: Amino Acids; Aspartic Acid; Calcium; Chlorophyll; Chlorophyll A; Cyanobacteria; Electron Transport; Glutamic Acid; Histidine; Kinetics; Light; Light-Harvesting Protein Complexes; Manganese; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxygen; Peptide Fragments; Photochemistry; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Plastoquinone; Structure-Activity Relationship; Water | 1995 |
Identification of Asp258 as the metal coordinate of pigeon liver malic enzyme by site-specific mutagenesis.
Topics: Amino Acids; Animals; Ascorbic Acid; Aspartic Acid; Base Sequence; Binding Sites; Columbidae; Ferrous Compounds; Kinetics; Liver; Magnesium; Malate Dehydrogenase; Manganese; Metalloproteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Structure-Activity Relationship | 1995 |
Kinetic and mutagenic studies of the role of the active site residues Asp-50 and Glu-327 of Escherichia coli glutamine synthetase.
Topics: Adenosine Triphosphate; Aspartic Acid; Binding Sites; Escherichia coli; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Kinetics; Manganese; Models, Chemical; Mutagenesis, Site-Directed; Quaternary Ammonium Compounds | 1994 |
Identification of residues in the Mu transposase essential for catalysis.
Topics: Amino Acid Sequence; Aspartic Acid; Bacteriophage mu; Binding Sites; Catalysis; Conserved Sequence; DNA Nucleotidyltransferases; DNA-Binding Proteins; Glutamates; Glutamic Acid; Integrases; Macromolecular Substances; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleotidyltransferases; Point Mutation; Recombinant Proteins; Sequence Homology, Amino Acid; Transposases | 1994 |
Role of disulfide linkage and putative intermolecular binding residues in the stability and binding of the extrinsic manganese-stabilizing protein to the photosystem II reaction center.
Topics: Aspartic Acid; Bacterial Proteins; Cyanobacteria; Disulfides; Lysine; Manganese; Metalloproteins; Mutagenesis, Site-Directed; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Protein Binding; Proteins | 1994 |
Affinity cleavage at the putative metal-binding site of pigeon liver malic enzyme by the Fe(2+)-ascorbate system.
Topics: Amino Acid Sequence; Animals; Ascorbic Acid; Aspartic Acid; Columbidae; Ferrous Compounds; Liver; Malate Dehydrogenase; Manganese; Metalloproteins; Molecular Sequence Data; Sequence Alignment; Sequence Homology, Amino Acid | 1994 |
Site-directed photosystem II mutants with perturbed oxygen-evolving properties. 1. Instability or inefficient assembly of the manganese cluster in vivo.
Topics: Aspartic Acid; Base Sequence; Binding Sites; Chlorophyll; Chlorophyll A; Cyanobacteria; Diuron; Electrochemistry; Electron Transport; Fluorometry; Light-Harvesting Protein Complexes; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxygen; Photochemistry; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Plastoquinone; Structure-Activity Relationship | 1994 |
Site-directed photosystem II mutants with perturbed oxygen-evolving properties. 2. Increased binding or photooxidation of manganese in the absence of the extrinsic 33-kDa polypeptide in vivo.
Topics: Aspartic Acid; Base Sequence; Binding Sites; Chlorophyll; Chlorophyll A; Cyanobacteria; Electrochemistry; Electron Transport; Fluorometry; Kinetics; Light-Harvesting Protein Complexes; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxygen; Photochemistry; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Plastoquinone | 1994 |
Mutational analysis of the human DNA polymerase alpha. The most conserved region in alpha-like DNA polymerases is involved in metal-specific catalysis.
Topics: Amino Acid Sequence; Animals; Aphidicolin; Aspartic Acid; Baculoviridae; Cell Line; Cloning, Molecular; Deoxyribonuclease I; DNA Polymerase II; DNA Replication; Escherichia coli; Humans; Hydrogen Bonding; Kinetics; Magnesium; Manganese; Moths; Mutagenesis, Site-Directed; Plasmids; Recombinant Proteins; Restriction Mapping; Templates, Genetic; Transfection | 1993 |
Asp537 and Asp812 in bacteriophage T7 RNA polymerase as metal ion-binding sites studied by EPR, flow-dialysis, and transcription.
Topics: Amino Acid Sequence; Aspartic Acid; Bacteriophage T7; Base Sequence; Binding Sites; Dialysis; DNA-Directed RNA Polymerases; Electron Spin Resonance Spectroscopy; Kinetics; Magnesium; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Protein Conformation; Recombinant Proteins; Transcription, Genetic; Viral Proteins | 1996 |
Characterization of manganese(II) binding site mutants of manganese peroxidase.
Topics: Aspartic Acid; Basidiomycota; Binding Sites; Isoenzymes; Kinetics; Ligands; Manganese; Models, Chemical; Mutagenesis, Site-Directed; Mutation; Peroxidases; Spectrophotometry; Spectrum Analysis, Raman | 1996 |
The type III connecting segment of fibronectin contains an aspartic acid residue that regulates the rate of binding to integrin alpha 4 beta 1.
Topics: Amino Acids; Animals; Aspartic Acid; Cell Adhesion; CHO Cells; Cloning, Molecular; Cricetinae; Escherichia coli; Fibronectins; Glutathione Transferase; Humans; Integrin alpha4beta1; Integrins; Magnesium; Manganese; Molecular Weight; Mutagenesis, Site-Directed; Protein Binding; Receptors, Fibronectin; Receptors, Lymphocyte Homing; Recombinant Fusion Proteins; Time Factors | 1996 |
Trichodiene synthase. Probing the role of the highly conserved aspartate-rich region by site-directed mutagenesis.
Topics: Aspartic Acid; Binding Sites; Carbon-Carbon Lyases; Catalysis; Conserved Sequence; Cyclohexenes; Escherichia coli; Fusarium; Kinetics; Lyases; Magnesium; Manganese; Mutagenesis, Site-Directed; Polyisoprenyl Phosphates; Recombinant Proteins; Sesquiterpenes | 1996 |
Aspartate-407 in Rhodobacter sphaeroides cytochrome c oxidase is not required for proton pumping or manganese binding.
Topics: Aspartic Acid; Binding Sites; Carbon Monoxide; Copper; Electron Transport; Electron Transport Complex IV; Manganese; Mutagenesis; Proton Pumps; Rhodobacter sphaeroides; Spectrum Analysis, Raman | 1997 |
Evidence supporting a role for histidine-235 in cation binding to human 3-hydroxy-3-methyglutaryl-CoA lyase.
Topics: Alanine; Aspartic Acid; Binding Sites; Catalysis; Cations, Divalent; Diethyl Pyrocarbonate; Electron Spin Resonance Spectroscopy; Histidine; Humans; Kinetics; Magnesium; Manganese; Mutagenesis, Site-Directed; Oxo-Acid-Lyases; Polymerase Chain Reaction; Structure-Activity Relationship | 1997 |
Asp-193 and Glu-218 of subunit II are involved in the Mn2+-binding of Paracoccus denitrificans cytochrome c oxidase.
Topics: Amino Acid Sequence; Aspartic Acid; Electron Spin Resonance Spectroscopy; Electron Transport Complex IV; Glutamic Acid; Manganese; Mutagenesis, Site-Directed; Paracoccus denitrificans; Protein Binding | 1997 |
Manganese decreases glutamate uptake in cultured astrocytes.
Topics: Adenosine Triphosphate; Ammonia; Animals; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; Drug Combinations; Glutamic Acid; Kinetics; Manganese; Rats; Sucrose | 1997 |
Nucleotide-binding properties of kinase-deficient epidermal-growth-factor-receptor mutants.
Topics: Adenosine Triphosphate; Aspartic Acid; Catalysis; Circular Dichroism; Cytosol; ErbB Receptors; Humans; Lysine; Manganese; Nucleotides; Phosphorylation; Point Mutation; Protein Binding; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Tryptophan | 1998 |
Experimental and theoretical characterization of the high-affinity cation-binding site of the purple membrane.
Topics: Aspartic Acid; Binding Sites; Cations, Divalent; Halobacterium salinarum; Kinetics; Magnesium; Magnetics; Manganese; Models, Molecular; Protein Structure, Secondary; Purple Membrane; Schiff Bases; Water | 1998 |
Effects of carboxyl amino acid modification on the properties of the high-affinity, manganese-binding site in photosystem II.
Topics: 2,6-Dichloroindophenol; Amino Acid Substitution; Aspartic Acid; Binding Sites; Diphenylcarbazide; Diuron; Ethyldimethylaminopropyl Carbodiimide; Ligands; Manganese; Oxidation-Reduction; Photochemistry; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Spectrometry, Fluorescence; Spinacia oleracea | 1998 |
Role of the first aspartate residue of the "YxDTDS" motif of phi29 DNA polymerase as a metal ligand during both TP-primed and DNA-primed DNA synthesis.
Topics: Aspartic Acid; Bacteriophages; Binding Sites; DNA Primers; DNA-Directed DNA Polymerase; DNA, Viral; Ligands; Manganese; Mutagenesis, Site-Directed; Protein Conformation; Templates, Genetic; Viral Proteins | 1998 |
The titrations of Asp-85 and of the cation binding residues in bacteriorhodopsin are not coupled.
Topics: Aspartic Acid; Bacteriorhodopsins; Binding Sites; Cations; Electron Spin Resonance Spectroscopy; Halobacterium salinarum; Hydrogen-Ion Concentration; Kinetics; Manganese; Mutation | 1999 |
Two-metal-Ion catalysis in adenylyl cyclase.
Topics: Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Aspartic Acid; Binding Sites; Catalysis; Crystallography, X-Ray; Deoxyadenine Nucleotides; Dideoxynucleotides; Dimerization; Enzyme Inhibitors; Hydrogen Bonding; Ligands; Magnesium; Manganese; Models, Molecular; Mutation; Protein Conformation; Protein Folding; Rats; Thionucleotides; Zinc | 1999 |
Plausible phosphoenolpyruvate binding site revealed by 2.6 A structure of Mn2+-bound phosphoenolpyruvate carboxylase from Escherichia coli.
Topics: Animals; Aspartic Acid; Binding Sites; Catalysis; Computer Simulation; Crystallography, X-Ray; Escherichia coli; Manganese; Models, Molecular; Peptide Fragments; Phosphoenolpyruvate; Phosphoenolpyruvate Carboxylase; Protein Structure, Secondary; Pyruvate Kinase; Rabbits; Sequence Homology, Amino Acid | 1999 |
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid; Binding Sites; Catalytic Domain; DNA Nucleotidyltransferases; DNA-Binding Proteins; Gene Rearrangement; HeLa Cells; Homeodomain Proteins; Humans; Hydroxyl Radical; Iron; Manganese; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Proteins; Phenotype; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Fusion Proteins; Structure-Activity Relationship; VDJ Recombinases | 1999 |
Mutational, kinetic, and NMR studies of the roles of conserved glutamate residues and of lysine-39 in the mechanism of the MutT pyrophosphohydrolase.
Topics: Adenosine Triphosphate; Aspartic Acid; Bacterial Proteins; Binding, Competitive; Catalysis; Chlorides; Conserved Sequence; DNA Mutational Analysis; Escherichia coli Proteins; Glutamic Acid; Glutamine; Kinetics; Lysine; Magnesium; Magnesium Chloride; Manganese; Manganese Compounds; Mutagenesis, Site-Directed; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Phosphoric Monoester Hydrolases; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protons; Pyrophosphatases; Recombinant Proteins; Solvents | 2000 |
Characterization of the functional role of Asp141, Asp194, and Asp464 residues in the Mn2+-L-malate binding of pigeon liver malic enzyme.
Topics: Animals; Aspartic Acid; Base Sequence; Binding Sites; Columbidae; Dimerization; DNA Primers; Escherichia coli; Humans; In Vitro Techniques; Kinetics; Liver; Malate Dehydrogenase; Malates; Manganese; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Quaternary; Recombinant Proteins; Thermodynamics | 2000 |
Manganese selectivity of pmr1, the yeast secretory pathway ion pump, is defined by residue gln783 in transmembrane segment 6. Residue Asp778 is essential for cation transport.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; Aspartic Acid; ATP-Binding Cassette Transporters; Binding Sites; Calcium-Transporting ATPases; Cations, Divalent; Egtazic Acid; Fungal Proteins; Glutamine; Histidine; Ion Pumps; Manganese; Models, Molecular; Molecular Chaperones; Molecular Sequence Data; Mutation; Peptides; Phosphoproteins; Phosphorylation; Protein Structure, Secondary; Protein Structure, Tertiary; Saccharomyces cerevisiae Proteins; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2000 |
Co-crystal of Escherichia coli RNase HI with Mn2+ ions reveals two divalent metals bound in the active site.
Topics: Aspartic Acid; Binding Sites; Catalysis; Catalytic Domain; Cations; Crystallography, X-Ray; Dose-Response Relationship, Drug; Escherichia coli; Glutamine; Magnesium; Manganese; Models, Biological; Ribonuclease H; Sodium Chloride | 2001 |
Identification of Asp218 and Asp326 as the principal Mg2+ binding ligands of the homing endonuclease PI-SceI.
Topics: Amino Acid Substitution; Aspartic Acid; Catalytic Domain; Cross-Linking Reagents; DNA-Binding Proteins; DNA, Fungal; Endodeoxyribonucleases; Hydrolysis; Ligands; Magnesium; Manganese; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Photochemistry; Protein Binding; Proton-Translocating ATPases; Saccharomyces cerevisiae Proteins | 2000 |
Mutational analysis of two putative catalytic motifs of the type IV restriction endonuclease Eco57I.
Topics: Amino Acid Motifs; Amino Acid Sequence; Aspartic Acid; Binding Sites; Catalysis; DNA; DNA Methylation; DNA Mutational Analysis; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutamic Acid; Magnesium; Manganese; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Site-Specific DNA-Methyltransferase (Adenine-Specific); Structure-Activity Relationship | 2001 |
Mechanism of action of Escherichia coli ribonuclease III. Stringent chemical requirement for the glutamic acid 117 side chain and Mn2+ rescue of the Glu117Asp mutant.
Topics: Aspartic Acid; Base Sequence; Binding Sites; Catalysis; Catalytic Domain; Cations, Divalent; Endoribonucleases; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Hydrolysis; Magnesium; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; Organophosphates; Protein Structure, Tertiary; Ribonuclease III; RNA Processing, Post-Transcriptional; Substrate Specificity | 2001 |
The role of Glu39 in MnII binding and oxidation by manganese peroxidase from Phanerochaete chrysoporium.
Topics: Amino Acid Substitution; Aspartic Acid; Binding Sites; Computer Simulation; Glutamic Acid; Kinetics; Manganese; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Peroxidases; Phanerochaete; Recombinant Proteins; Sequence Analysis, DNA; Spectrophotometry, Ultraviolet | 2001 |
Mutational analysis of catalytic sites of the cell wall lytic N-acetylmuramoyl-L-alanine amidases CwlC and CwlV.
Topics: Amino Acid Sequence; Amino Acids; Aspartic Acid; Bacillus; Bacillus subtilis; Bacterial Proteins; Calcium; Catalysis; Catalytic Domain; Cations; Cell Wall; Circular Dichroism; Cobalt; DNA Mutational Analysis; Electrophoresis, Polyacrylamide Gel; Gene Deletion; Glutamic Acid; Magnesium; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Acetylmuramoyl-L-alanine Amidase; Peptidoglycan; Plasmids; Point Mutation; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Time Factors; Zinc | 2001 |
DNA polymerase beta: pre-steady-state kinetic analyses of dATP alpha S stereoselectivity and alteration of the stereoselectivity by various metal ions and by site-directed mutagenesis.
Topics: Animals; Arginine; Aspartic Acid; Cadmium; Cations, Divalent; Deoxyadenine Nucleotides; DNA Polymerase beta; DNA Polymerase I; Kinetics; Magnesium; Manganese; Metals; Mutagenesis, Site-Directed; Rats; Stereoisomerism; Thionucleotides | 2001 |
Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway.
Topics: Aspartic Acid; Bacterial Proteins; Binding Sites; Catalysis; Crystallography, X-Ray; Escherichia coli; Escherichia coli Proteins; Histidine; Manganese; Mevalonic Acid; Models, Chemical; Models, Molecular; Oxygen; Phosphates; Phosphorus-Oxygen Lyases; Protein Binding; Protein Structure, Quaternary; Substrate Specificity | 2002 |
Electrostatic contributions to site specific DNA cleavage by EcoRV endonuclease.
Topics: Alanine; Aspartic Acid; Binding Sites; Catalysis; Cations, Divalent; Crystallography, X-Ray; Deoxyribonucleases, Type II Site-Specific; DNA, Bacterial; Glutamic Acid; Kinetics; Lysine; Manganese; Mutagenesis, Site-Directed; Static Electricity | 2002 |
Biochemical characterization of the Arabidopsis protein kinase SOS2 that functions in salt tolerance.
Topics: Adaptation, Physiological; Amino Acid Sequence; Amino Acid Substitution; Arabidopsis; Arabidopsis Proteins; Aspartic Acid; Cations, Divalent; Enzyme Activation; Escherichia coli; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Glutathione Transferase; Hydrogen-Ion Concentration; Magnesium; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Serine; Signal Transduction; Substrate Specificity; Tyrosine | 2002 |
Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling.
Topics: Amino Acid Sequence; Animals; Arginase; Aspartic Acid; Circular Dichroism; Edetic Acid; Escherichia coli; Kinetics; Liver; Manganese; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Rats; Sequence Homology, Amino Acid; Spectrometry, Fluorescence; Ureohydrolases | 2002 |
Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Blotting, Northern; Carrier Proteins; Cells, Cultured; Manganese; Membrane Glycoproteins; Membrane Transport Proteins; Metallothionein; Rats; tau Proteins; Taurine | 2002 |
Dispensability of glutamic acid 48 and aspartic acid 134 for Mn2+-dependent activity of Escherichia coli ribonuclease HI.
Topics: Aspartic Acid; Base Sequence; Calorimetry; Circular Dichroism; DNA Primers; Escherichia coli; Genes, Bacterial; Glutamic Acid; Hydrogen-Ion Concentration; Manganese; Mutagenesis; Mutagenesis, Site-Directed; Ribonuclease H; Spectrophotometry, Ultraviolet; Thermodynamics | 2003 |
Characterization of the interactions between Asp141 and Phe236 in the Mn2+-l-malate binding of pigeon liver malic enzyme.
Topics: Animals; Aspartic Acid; Binding Sites; Columbidae; Kinetics; Liver; Malate Dehydrogenase; Malates; Manganese; Metals; Mutagenesis, Site-Directed; Phenylalanine; Protein Binding; Recombinant Proteins; Thermodynamics | 2003 |
Specific isotopic labeling and photooxidation-linked structural changes in the manganese-stabilizing subunit of photosystem II.
Topics: Asparagine; Aspartic Acid; Escherichia coli; Gas Chromatography-Mass Spectrometry; Gene Expression; Glutamic Acid; Glutamine; Isotope Labeling; Manganese; Oxidation-Reduction; Photochemistry; Photosynthesis; Photosystem II Protein Complex; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared; Water | 2003 |
Does aspartate 170 of the D1 polypeptide ligate the manganese cluster in photosystem II? An EPR and ESEEM Study.
Topics: Amino Acid Substitution; Aspartic Acid; Cyanobacteria; Electron Spin Resonance Spectroscopy; Fourier Analysis; Histidine; Light; Manganese; Mutagenesis, Site-Directed; Photosynthetic Reaction Center Complex Proteins; Protein Subunits; Recombinant Proteins | 2003 |
[RESEARCH ON THE NUTRITION OF ERWINIA CAROTOVORA].
Topics: Alanine; Aminobutyrates; Ammonium Compounds; Arginine; Asparagine; Aspartic Acid; Boron; Calcium; Cobalt; Copper; Creatine; Creatinine; Culture; Culture Media; Cysteine; Cystine; Erwinia; Glutamates; Glycine; Iron; Lysine; Magnesium; Manganese; Methionine; Minerals; Molybdenum; Pectobacterium carotovorum; Proteins; Quaternary Ammonium Compounds; Tryptophan; Tyrosine; Zinc | 1963 |
DIVALENT METAL ION ACTIVATION OF BETA-METHYLASPARTASE.
Topics: Ammonia; Ammonia-Lyases; Aspartic Acid; Benzoates; Cadmium; Calcium; Cations, Divalent; Chemical Phenomena; Chemistry, Physical; Clostridium; Cobalt; Copper; Cysteine; Fumarates; Ions; Iron; Lyases; Magnesium; Manganese; Nickel; Pharmacology; Research; Spectrophotometry; Zinc | 1964 |
PURIFICATION AND PROPERTIES OF THE ASPARAGINE SYNTHETASE OF STREPTOCOCCUS BOVIS.
Topics: Amino Acids; Ammonium Chloride; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Chromatography; Dialysis; Diphosphates; Enzyme Inhibitors; Hydroxamic Acids; Ligases; Manganese; Pharmacology; Renal Dialysis; Research; Streptococcus; Streptococcus bovis | 1964 |
Ligands of the Mn2+ bound to porcine mitochondrial NADP-dependent isocitrate dehydrogenase, as assessed by mutagenesis.
Topics: Animals; Aspartic Acid; Binding Sites; Cations, Divalent; Circular Dichroism; Hydrogen-Ion Concentration; Isocitrate Dehydrogenase; Kinetics; Ligands; Manganese; Mitochondria, Heart; Mutagenesis, Site-Directed; Recombinant Proteins; Substrate Specificity; Swine | 2004 |
The HD domain of the Escherichia coli tRNA nucleotidyltransferase has 2',3'-cyclic phosphodiesterase, 2'-nucleotidase, and phosphatase activities.
Topics: Adenosine Monophosphate; Amino Acid Sequence; Aspartic Acid; Calcium; Chromatography, Thin Layer; Cloning, Molecular; Conserved Sequence; Cyclic AMP; Cyclic CMP; Cyclic GMP; Dose-Response Relationship, Drug; Escherichia coli; Histidine; Hydrolysis; Ions; Kinetics; Magnesium; Manganese; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nickel; Nucleotidases; Phosphoric Diester Hydrolases; Protein Structure, Tertiary; RNA Nucleotidyltransferases; Substrate Specificity | 2004 |
The adenovirus priming protein pTP contributes to the kinetics of initiation of DNA replication.
Topics: Adenoviruses, Human; Amino Acid Sequence; Aspartic Acid; DNA-Directed DNA Polymerase; DNA, Viral; Kinetics; Manganese; Molecular Sequence Data; Mutation; Phosphoproteins; Protein Precursors; Sequence Alignment; Serine; Viral Proteins; Virus Replication | 2004 |
Coordination of divalent metal ions in the active site of poly(A)-specific ribonuclease.
Topics: Adenosine; Aspartic Acid; Binding Sites; Cadmium; Cobalt; Conserved Sequence; Exoribonucleases; Glutamic Acid; Humans; Hydrolysis; Ions; Kinetics; Magnesium; Manganese; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Oxygen; Protein Binding; Recombinant Proteins; RNA; RNA, Messenger; Stereoisomerism; Substrate Specificity; Zinc | 2004 |
Mutational analysis of the nuclease domain of Escherichia coli ribonuclease III. Identification of conserved acidic residues that are important for catalytic function in vitro.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Base Sequence; Catalysis; Catalytic Domain; Conserved Sequence; DNA Mutational Analysis; DNA, Bacterial; Escherichia coli Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Hydrolysis; Manganese; Molecular Sequence Data; Protein Subunits; Ribonuclease III; Sequence Alignment; Sequence Homology, Amino Acid | 2004 |
Mechanistic insights from the structures of HincII bound to cognate DNA cleaved from addition of Mg2+ and Mn2+.
Topics: Aspartic Acid; Bacteria; Crystallography, X-Ray; Deoxyribonucleases, Type II Site-Specific; DNA; Glutamic Acid; Magnesium; Manganese; Phosphates; Protein Structure, Tertiary | 2004 |
Identification of functional amino acids in the Nramp family by a combination of evolutionary analysis and biophysical studies of metal and proton cotransport in vivo.
Topics: Amino Acids; Asparagine; Aspartic Acid; Cadmium; Cation Transport Proteins; Cell Membrane Permeability; Cobalt; Escherichia coli Proteins; Evolution, Molecular; Ferrous Compounds; Histidine; Manganese; Metals, Heavy; Mutagenesis, Site-Directed; Protein Transport; Proto-Oncogene Proteins c-myc; Protons | 2005 |
Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase.
Topics: Adenosine Triphosphate; Adenylosuccinate Synthase; Aminoimidazole Carboxamide; Aspartic Acid; Bacterial Proteins; Chromatography, High Pressure Liquid; Cloning, Molecular; Enzyme Inhibitors; Escherichia coli Proteins; Hydrogen-Ion Concentration; Inosine Monophosphate; Kinetics; Magnesium; Manganese; Models, Chemical; Peptide Synthases; Recombinant Proteins; Ribonucleosides; Substrate Specificity | 2005 |
Identification of single Mn(2+) binding sites required for activation of the mutant proteins of E.coli RNase HI at Glu48 and/or Asp134 by X-ray crystallography.
Topics: Aspartic Acid; Binding Sites; Crystallography, X-Ray; Enzyme Activation; Escherichia coli; Glutamic Acid; Manganese; Models, Molecular; Mutation; Protein Structure, Tertiary; Ribonuclease H | 2005 |
Functional roles of carboxylate residues comprising the DNA polymerase active site triad of Ty3 reverse transcriptase.
Topics: Amino Acid Substitution; Aspartic Acid; Binding Sites; DNA; DNA-Directed DNA Polymerase; Kinetics; Manganese; Mutagenesis, Site-Directed; Phosphoric Acids; Retroelements; Ribonuclease H; RNA-Directed DNA Polymerase; Saccharomyces cerevisiae Proteins | 2005 |
No evidence from FTIR difference spectroscopy that aspartate-170 of the D1 polypeptide ligates a manganese ion that undergoes oxidation during the S0 to S1, S1 to S2, or S2 to S3 transitions in photosystem II.
Topics: Aspartic Acid; Carboxylic Acids; Cations, Divalent; Ligands; Manganese; Mutagenesis, Site-Directed; Photolysis; Photosystem II Protein Complex; Spectroscopy, Fourier Transform Infrared; Synechocystis | 2005 |
Metal-induced structural organization and stabilization of the metalloregulatory protein MntR.
Topics: Anilino Naphthalenesulfonates; Arginine; Aspartic Acid; Bacillus subtilis; Bacterial Proteins; Binding Sites; Circular Dichroism; DNA-Binding Proteins; Fluorescent Dyes; Glutamic Acid; Hot Temperature; Manganese; Metals, Heavy; Methionine; Protein Conformation; Protein Denaturation; Repressor Proteins | 2005 |
Identification of residues essential for carbohydrate recognition and cation dependence of the 46-kDa mannose 6-phosphate receptor.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Carbohydrate Metabolism; Cations; Cattle; Dogs; Electron Spin Resonance Spectroscopy; Glucuronidase; Histidine; Humans; Lectins; Lysosomes; Manganese; Mice; Molecular Sequence Data; Rats; Receptors, Cell Surface; Surface Plasmon Resonance; Time Factors | 2005 |
Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate.
Topics: Adenosine Diphosphate; Amino Acid Motifs; Arylsulfotransferase; Aspartic Acid; Crystallography, X-Ray; Dopamine; Glutamine; Humans; Ligands; Manganese; Models, Molecular; Protein Binding; Protein Conformation; Static Electricity; Stereoisomerism; Sulfotransferases | 2005 |
Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Escherichia coli; Humans; Isocitrate Dehydrogenase; Kinetics; Manganese; Molecular Sequence Data; Mutagenesis; Oxygen; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Swine | 2006 |
Metal ion-mediated reduction in surface entropy improves diffraction quality of crystals of the IRAK-4 death domain.
Topics: Animals; Aspartic Acid; Catalytic Domain; Chlorides; Crystallography, X-Ray; Entropy; Humans; Interleukin-1 Receptor-Associated Kinases; Ions; Lysine; Manganese; Manganese Compounds; Mice; Mutagenesis; Phosphotransferases (Alcohol Group Acceptor); Point Mutation; Protein Conformation; Protein Structure, Tertiary; X-Ray Diffraction | 2006 |
Effect of occupational manganese exposure on the central nervous system of welders: 1H magnetic resonance spectroscopy and MRI findings.
Topics: Adult; Air Pollutants; Aspartic Acid; Basal Ganglia; Behavior; Biomarkers; Case-Control Studies; Central Nervous System; Choline; Creatine; Dose-Response Relationship, Drug; Environmental Monitoring; Globus Pallidus; Humans; Korea; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Manganese; Manganese Compounds; Middle Aged; Motor Skills; Neurons; Neuropsychological Tests; Occupational Exposure; Signal Processing, Computer-Assisted; Time Factors; Welding | 2007 |
Identification by Mn2+ rescue of two residues essential for the proton transfer of tRNase Z catalysis.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Base Sequence; Catalysis; Catalytic Domain; Cations, Divalent; Endoribonucleases; Histidine; Manganese; Metals; Molecular Sequence Data; Protons; RNA Precursors; RNA, Transfer; Thermotoga maritima | 2006 |
Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Creatine; Macaca fascicularis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Manganese; Manganese Poisoning | 2006 |
No evidence from FTIR difference spectroscopy that aspartate-342 of the D1 polypeptide ligates a Mn ion that undergoes oxidation during the S0 to S1, S1 to S2, or S2 to S3 transitions in photosystem II.
Topics: Amino Acid Sequence; Aspartic Acid; Ligands; Manganese; Oxidation-Reduction; Photosystem II Protein Complex; Point Mutation; Spectroscopy, Fourier Transform Infrared; Synechocystis | 2007 |
Morphological and metabolic changes in the cortex of mice lacking the functional presynaptic active zone protein bassoon: a combined 1H-NMR spectroscopy and histochemical study.
Topics: Animals; Aspartic Acid; Brain Mapping; Cerebellum; Cerebral Cortex; Female; Glutamic Acid; Glutamine; Histocytochemistry; Male; Manganese; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nerve Tissue Proteins; Neuroglia; Neurons; Nuclear Magnetic Resonance, Biomolecular; Presynaptic Terminals; Protons | 2008 |
Effect of paramagnetic manganese cations on (1)H MRS of the brain.
Topics: Animals; Aspartic Acid; Brain; Cations; Choline; Creatine; Electron Spin Resonance Spectroscopy; Male; Manganese; Protons; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity | 2008 |
[Study on main effectual ingredient content in fresh juice of Panax quinquefolium].
Topics: Amino Acids; Aspartic Acid; Fruit; Ginsenosides; Glutamic Acid; Iron; Manganese; Panax; Plants, Medicinal; Trace Elements | 2008 |
Functional analyses for tRNase Z variants: an aspartate and a histidine in the active site are essential for the catalytic activity.
Topics: Amino Acid Substitution; Aspartic Acid; Bacillus subtilis; Bacterial Proteins; Catalysis; Catalytic Domain; Endoribonucleases; Escherichia coli; Histidine; Manganese; Thermotoga maritima | 2008 |
Density functional theory study of the manganese-containing ribonucleotide reductase from Chlamydia trachomatis: why manganese is needed in the active complex.
Topics: Aspartic Acid; Bacterial Proteins; Binding Sites; Chlamydia trachomatis; Glutamine; Iron; Manganese; Models, Molecular; Protein Binding; Protein Structure, Tertiary; Protons; Ribonucleotide Reductases; Thermodynamics; Tyrosine | 2009 |
Neurochemical changes in welders revealed by proton magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Brain Chemistry; Case-Control Studies; Choline; Environmental Exposure; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Manganese; Middle Aged; Neurologic Examination; Protons; Spectrum Analysis; Statistics as Topic; Surveys and Questionnaires; Welding | 2009 |
Asp157 is required for the function of PsbO, the photosystem II manganese stabilizing protein.
Topics: Amino Acid Sequence; Aspartic Acid; Catalytic Domain; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oxygen; Photosystem II Protein Complex; Plant Proteins; Spinacia oleracea; Structure-Activity Relationship; Synechococcus | 2009 |
Characterization of RNase HII substrate recognition using RNase HII-argonaute chimaeric enzymes from Pyrococcus furiosus.
Topics: Amino Acid Sequence; Archaeal Proteins; Arginine; Aspartic Acid; Base Sequence; Binding Sites; Catalysis; Electrophoresis, Polyacrylamide Gel; Endoribonucleases; Kinetics; Manganese; Models, Molecular; Molecular Sequence Data; Phenylalanine; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrococcus furiosus; Recombinant Fusion Proteins; Ribonuclease H; RNA-Binding Proteins; RNA, Double-Stranded; Sequence Homology, Amino Acid; Substrate Specificity | 2010 |
Type IIA topoisomerase inhibition by a new class of antibacterial agents.
Topics: Anti-Bacterial Agents; Apoenzymes; Arginine; Aspartic Acid; Binding Sites; Catalytic Domain; Ciprofloxacin; Crystallography, X-Ray; DNA; DNA Cleavage; DNA Gyrase; DNA, Superhelical; Drug Design; Drug Resistance; Escherichia coli; Manganese; Models, Molecular; Protein Conformation; Quinolines; Quinolones; Staphylococcus aureus; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2010 |
Ligation of D1-His332 and D1-Asp170 to the manganese cluster of photosystem II from Synechocystis assessed by multifrequency pulse EPR spectroscopy.
Topics: Aspartic Acid; Electron Spin Resonance Spectroscopy; Histidine; Manganese; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Oxygen; Photosystem II Protein Complex; Protein Conformation; Synechocystis | 2011 |
Pathophysiology of manganese-associated neurotoxicity.
Topics: Air Pollutants, Occupational; Animals; Aspartic Acid; Brain; Dopamine; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Manganese; Manganese Poisoning; Models, Animal; Occupational Diseases; Occupational Exposure; Occupational Health; Parkinson Disease, Secondary; Phenotype; Positron-Emission Tomography; Risk Assessment; Risk Factors | 2012 |
Affinity purification and characterization of a seed lectin from Crotalaria medicaginea.
Topics: ABO Blood-Group System; Amino Acids; Animals; Asialoglycoproteins; Aspartic Acid; Calcium; Chromatography, Affinity; Crotalaria; Fetuins; Glutamic Acid; Hemagglutinins; Humans; Hydrogen-Ion Concentration; Ions; Lectins; Manganese; Neuraminidase; Rabbits; Rats; Seeds; Temperature | 2002 |
The crystal structure of the lipid II-degrading bacteriocin syringacin M suggests unexpected evolutionary relationships between colicin M-like bacteriocins.
Topics: Amino Acid Sequence; Aspartic Acid; Bacteriocins; Calcium; Catalysis; Catalytic Domain; Crystallography, X-Ray; Ions; Magnesium; Manganese; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Mutation; Phosphoric Monoester Hydrolases; Phylogeny; Pseudomonas syringae; Sequence Homology, Amino Acid; Uridine Diphosphate N-Acetylmuramic Acid | 2012 |
Structural and functional insights into the regulation of Helicobacter pylori arginase activity by an evolutionary nonconserved motif.
Topics: Amino Acid Substitution; Arginase; Aspartic Acid; Bacterial Proteins; Biocatalysis; Circular Dichroism; Cobalt; Enzyme Stability; Helicobacter pylori; Hot Temperature; Kinetics; Manganese; Molecular Docking Simulation; Mutagenesis, Site-Directed; Mutant Proteins; Peptide Fragments; Protein Denaturation; Protein Interaction Domains and Motifs; Recombinant Proteins; Tryptophan | 2013 |
Altered reward circuitry in the norepinephrine transporter knockout mouse.
Topics: Animals; Aspartic Acid; Brain; Brain Mapping; Contrast Media; Dopamine Plasma Membrane Transport Proteins; Female; Injections, Intraventricular; Magnetic Resonance Imaging; Male; Manganese; Mice; Mice, Knockout; Neurons; Norepinephrine Plasma Membrane Transport Proteins; Reward; Serotonin Plasma Membrane Transport Proteins; Stereotaxic Techniques; Synaptic Transmission | 2013 |
Kinetic and spectroscopic studies of bicupin oxalate oxidase and putative active site mutants.
Topics: Arginine; Aspartic Acid; Biocatalysis; Catalytic Domain; Coriolaceae; Fungal Proteins; Hydrogen-Ion Concentration; Kinetics; Manganese; Models, Molecular; Mutation; Oxalates; Oxidoreductases; Pichia; Protein Binding; Protons; Recombinant Proteins; Substrate Specificity | 2013 |
Binding of a third metal ion by the human phosphatases PP2Cα and Wip1 is required for phosphatase activity.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Catalysis; Catalytic Domain; HEK293 Cells; Humans; Magnesium; Manganese; Phosphopeptides; Phosphoprotein Phosphatases; Protein Phosphatase 2C; Sequence Alignment | 2013 |
Divalent metal ion-induced folding mechanism of RNase H1 from extreme halophilic archaeon Halobacterium sp. NRC-1.
Topics: Amino Acid Sequence; Archaeal Proteins; Aspartic Acid; Catalytic Domain; Cations, Divalent; Crystallography, X-Ray; Escherichia coli; Gene Expression; Halobacterium; Magnesium; Manganese; Models, Molecular; Molecular Sequence Data; Mutation; Protein Binding; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Ribonuclease H; Sequence Alignment; Sodium Chloride | 2014 |
Effects of metal ions and hydrogen peroxide on the phenotype of yeast hom6Δ mutant.
Topics: Aerobiosis; Anaerobiosis; Aspartic Acid; Culture Media; Gene Deletion; Homoserine Dehydrogenase; Hydrogen Peroxide; Manganese; Metabolic Networks and Pathways; Metals; Mutation; Oxidants; Phenotype; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2015 |
Effect of concomitant oxidation and deprotonation of hydrated Mn centres in rationalising the FTIR difference silence of D1-Asp170 in Photosystem II.
Topics: Aspartic Acid; Manganese; Oxidation-Reduction; Photosystem II Protein Complex; Protons; Spectroscopy, Fourier Transform Infrared; Water | 2016 |
Characterization of Drosophila CMP-sialic acid synthetase activity reveals unusual enzymatic properties.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cells, Cultured; Drosophila; Drosophila Proteins; Humans; Hydrogen-Ion Concentration; Kinetics; Magnesium; Manganese; Mutation; N-Acylneuraminate Cytidylyltransferase; Phylogeny; Structure-Activity Relationship; Substrate Specificity; Temperature | 2016 |
Cd(2+) sensitivity and permeability of a low voltage-activated Ca(2+) channel with CatSper-like selectivity filter.
Topics: Aspartic Acid; Cadmium; Calcium Channels; Calcium Channels, T-Type; Cell Membrane; Cell Membrane Permeability; HEK293 Cells; Humans; Ion Channel Gating; Male; Manganese; Mutant Proteins; Mutation; Progesterone; Spermatozoa | 2016 |
Reactive oxygen species leave a damage trail that reveals water channels in Photosystem II.
Topics: Aspartic Acid; Bacterial Proteins; Chromatography, High Pressure Liquid; Cyanobacteria; Manganese; Molecular Dynamics Simulation; Oxidation-Reduction; Peptides; Photosystem II Protein Complex; Reactive Oxygen Species; Tandem Mass Spectrometry; Water | 2017 |
Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Topics: Alanine; Amino Acid Substitution; Asparagine; Aspartic Acid; Bacterial Proteins; Catalytic Domain; Crystallography, X-Ray; Flap Endonucleases; Manganese; Models, Molecular; Mutation; Mycobacterium smegmatis; Phosphodiesterase I | 2018 |
GLAST Activity is Modified by Acute Manganese Exposure in Bergmann Glial Cells.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Manganese; Neuroglia | 2020 |
Effects of repeated manganese treatment on proton magnetic resonance spectra of the globus pallidus in rat brain.
Topics: Animals; Aspartic Acid; Choline; Creatine; Globus Pallidus; Manganese; Proton Magnetic Resonance Spectroscopy; Rats; Rats, Sprague-Dawley | 2022 |
Oral magnesium sulphate administration in rats with minimal hepatic encephalopathy: NMR-based metabolic characterization of the brain
Topics: Administration, Oral; Alanine; Animals; Aspartic Acid; Brain; Glutamates; Hepatic Encephalopathy; Magnesium Sulfate; Magnetic Resonance Spectroscopy; Manganese; Rats; Rats, Sprague-Dawley | 2022 |