aspartic acid has been researched along with malic acid in 170 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (19.41) | 18.7374 |
| 1990's | 32 (18.82) | 18.2507 |
| 2000's | 49 (28.82) | 29.6817 |
| 2010's | 48 (28.24) | 24.3611 |
| 2020's | 8 (4.71) | 2.80 |
| Authors | Studies |
|---|---|
| Matsuno, T | 3 |
| D'Souza, NB; Deaciuc, IV; Lang, CH; Spitzer, JJ | 1 |
| Dey, S; Sharma, R; Verma, R | 1 |
| Berry, MN; Grivell, AR; Phillips, JW | 1 |
| Berry, MN; Gregory, RB; Grivell, AR; Phillips, JW; Wallace, PG | 1 |
| Denger, K; Schink, B | 1 |
| Salminen, SO; Streeter, JG | 2 |
| Handler, JA; Kizaki, Z; Sugano, T; Thurman, RG; Yoshihara, H | 1 |
| Dworkin, MB; Dworkin-Rastl, E | 1 |
| Iakovleva, VI; Verevkin, AN; Zueva, NN | 1 |
| Angielski, S; Bizon, D; Piec, G; Stepiński, J | 1 |
| Hassinen, IE; Hiltunen, JK; Kauppinen, RA | 1 |
| Chagoya de Sánchez, V; Díaz-Muñoz, M; Hernández-Muñoz, R | 1 |
| Lenartowicz, E; Wojtczak, AB | 1 |
| Grieshaber, MK; Kreutzer, U; Rösen, P; Wiesner, RJ | 1 |
| Berdanier, CD; Deaver, OE; McCusker, RH; Wander, RC | 1 |
| Donnell, GN; Ng, WG; Oizumi, J | 1 |
| Burnell, JN; Hatch, MD | 1 |
| Cheeseman, AJ; Clark, JB | 1 |
| Hochachka, PW; Mommsen, TP | 1 |
| Kauppinen, RA; Nicholls, DG; Sihra, TS | 1 |
| Dimitriadis, E; Dry, IB; Ward, AD; Wiskich, JT | 1 |
| Tomasiak, M | 1 |
| Miyamae, Y; Ohta, T; Sugano, T; Tarui, A | 1 |
| Baquer, NZ; Kazmi, SM; Mayanil, CS | 1 |
| Groen, AK; Leverve, XM; Meijer, AJ; Tager, JM; Verhoeven, AJ | 1 |
| Martínez, P; Núñez de Castro, I; Olavarría, JS; Sánchez-Jiménez, F | 1 |
| Mori, M; Shiio, I | 1 |
| Day, DA; Hatch, MD | 1 |
| Hassinen, IE; Hiltunen, JK; Nuutinen, EM; Peuhkurinen, KJ; Pietiläinen, EP | 1 |
| Amicarelli, F; Paponetti, B; Petrucci, D | 1 |
| MacDonald, MJ | 1 |
| Deaciuc, IV; Ilonca, A | 1 |
| Muñoz-Clares, R; Sánchez-Medina, F; Sánchez-Pozo, A; Vargas, A | 1 |
| Flossmann, KD; Höfer, M | 1 |
| Koppenhafer, SL; Scholz, TD | 1 |
| Catelloni, F; Fontaine, E; Keriel, C; Leverve, XM; Rigoulet, M; Sibille, B | 1 |
| Berry, MN; Grivell, AR; Korpelainen, EI; Williams, CJ | 1 |
| Shibatani, T; Tosa, T | 1 |
| Beal, MF; Brouillet, E; Henshaw, DR; Schulz, JB | 1 |
| Duyckaerts, C; Evens, A; Hautecler, JJ; Sluse, FE; Sluse-Goffart, CM | 1 |
| Scaduto, RC | 1 |
| Fujimoto, Y; Hiramatsu, M; Kimura, K; Moriyama, M; Ohta, M; Shiota, M; Sugano, T | 1 |
| Nishimura, K | 1 |
| Martin, SA; Park, CM | 1 |
| Barak, R; Eisenbach, M; Giebel, I | 1 |
| Izui, K; Minoguchi, S; Nakamura, T | 1 |
| Izui, K; Yano, M | 1 |
| Carter, JG; Chi, MM; Lowry, OH; Pusateri, ME; Ryan, C; Schlesinger, MJ | 1 |
| Hata, S; Izui, K; Ueno, Y | 1 |
| Atlante, A; Gagliardi, S; Passarella, S | 1 |
| Koppenhafer, SL; Scholz, TD; Schutte, BC; tenEyck, CJ | 1 |
| Barron, JT; Gu, L; Parrillo, JE | 1 |
| Geck, MK; Kirsch, JF | 1 |
| Kvamme, E; Roberg, B; Torgner, IA | 1 |
| Lewandowski, ED; O'Donnell, JM; White, LT | 1 |
| Bildl, W; Holler, E; Lee, BS; Willibald, B | 1 |
| Cao, NJ; Du, J; Gong, CS; Tsao, GT | 1 |
| Eto, K; Henquin, JC; Jonkers, FC; Kadowaki, T; Nenquin, M; Ravier, MA | 1 |
| Ahn, YH; Bae, JH; Earm, YE; Ho, WK; Hong, YS; Park, WK; Song, DK | 1 |
| Chang, GG; Chang, HP; Chou, WY; Huang, CH; Kuo, CC; Tong, L | 1 |
| Beebe, D; Brownlee, M; Du, XL; Edelstein, D; Giardino, I; Hammes, HP; Kaneda, Y; Matsumura, T; Nishikawa, T; Oates, PJ; Yamagishi, S; Yorek, MA | 1 |
| Dong, Z; Nissim, I; Roeser, NF; Saikumar, P; Senter, RA; Venkatachalam, MA; Weinberg, JM | 1 |
| Rupert, BE; Scholz, TD; Schutte, BC; Segar, JL | 1 |
| Edwards, JS; McCulloch, A; Palsson, BO; Ramakrishna, R | 1 |
| Decking, UK; Deussen, A; Preckel, B; Schrader, J; Skwirba, S; Thämer, V; Zimmermann, MF | 1 |
| Bonnet, E; Dion, C; Jeandet, P; Maujean, A; Vasserot, Y | 1 |
| Arai, T; Kamata, S; Sako, T; Takahashi, M | 1 |
| Carvalho, RA; Jeffrey, FM; Malloy, CR; Sherry, AD; Wiegers, CB; Zhao, P | 1 |
| Clarke, RJ; Frank, J; Holzwarth, JF; Vater, J | 1 |
| Lyngdoh, HG; Sharma, R | 1 |
| Arai, T; Azakami, D; Ikeda, M; Takahashi, M; Washizu, T | 1 |
| Chen, LM; Hata, S; Izui, K; Omiya, T | 1 |
| Levitt, P; Lewis, DA; Middleton, FA; Mirnics, K; Pierri, JN | 1 |
| Hayashi, H; Hirotsu, K; Kagamiyama, H; Miyahara, I; Mizuguchi, H; Nakajima, Y | 1 |
| Arai, T; Inoue, A; Kimura, N; Sako, T; Uematsu, Y | 1 |
| TAGER, JM | 1 |
| OSBORNE-WHITE, WS; RUSSELL, GR; SMITH, RM | 1 |
| KORNBERG, HL; MORRIS, JG | 1 |
| JOHNSON, PA; QUAYLE, JR | 1 |
| Blanco, E; Cavero, S; Cerdán, S; del Arco, A; Palmieri, F; Palmieri, L; Runswick, MJ; Satrústegui, J; Villa, A; Vozza, A; Walker, JE | 1 |
| Carvalho, RA; Jeffrey, FM; Malloy, CR; Rodrigues, TB; Sherry, AD; Zhao, P | 1 |
| Ralphe, JC; Scholz, TD; Schutte, BC; Segar, JL | 1 |
| Hagopian, K; Ramsey, JJ; Weindruch, R | 1 |
| Bartley, C; del Arco, A; Maechler, P; Rubi, B; Satrustegui, J | 1 |
| Bedell, K; Ralphe, JC; Scholz, TD; Segar, JL | 1 |
| Gardner, DK; Lane, M | 1 |
| Capetanaki, Y; Fountoulakis, M; Maris, A; Mavroidis, M; Rapti, K; Soumaka, E; Tsangaris, G; Weisleder, N | 1 |
| Aleksanyan, GA; Bagdasaryan, SN; Bagdasaryan, ZN; Mirzoyan, AM; Roseiro, JC | 1 |
| Hertz, L; Kala, G | 1 |
| Cabrera, ME; Saidel, GM; Stanley, WC; Yu, X; Zhou, L | 1 |
| Grover, S; Mendez, J; Sanchez, N; Sanchez, S; Sayegh, J; Sward, L; Waldrop, G; Yuan, J | 1 |
| Jastrzebski, H; Parys, E | 1 |
| Cai, M; Chen, R; Huang, JM; Tan, JB; Wu, JL; Wu, QP | 1 |
| Halliwell, B; Ng, LE; Vincent, AS; Wong, KP | 1 |
| Goyary, D; Sharma, R | 2 |
| Bender, K; Brennan, L; Maechler, P; Newsholme, P | 1 |
| Contreras, L; Gomez-Puertas, P; Iijima, M; Kobayashi, K; Saheki, T; Satrústegui, J | 1 |
| Baker, KE; Kelln, RA; Krogan, NJ; Lamb, SS; Neuhard, J; Zaharik, ML | 1 |
| Kulp, EA; Switzer, JA | 1 |
| Agarie, S; Hong, HT; Nose, A; Yoshida, T | 1 |
| Mali, Y; Zisapels, N | 1 |
| Cashman, KS; Gardner, DK; Lane, M; Mitchell, M; Thompson, JG | 1 |
| Contreras, L; Satrústegui, J | 1 |
| Gregory, AL; Hurley, BA; Knowles, VL; Plaxton, WC; She, YM; Tran, HT; Valentine, AJ | 1 |
| Bak, LK; Ring, A; Schousboe, A; Sonnewald, U; Waagepetersen, HS; Walls, AB | 1 |
| Janssen, DB; Poelarends, GJ; Puthan Veetil, V; Quax, WJ; Raj, H | 1 |
| Arun, P; Moffett, JR; Namboodiri, AM | 1 |
| Cameron, JM; Des Rosiers, C; Khairallah, M; Pencharz, PB; Riazi, R; Robinson, BH | 1 |
| Ceulemans, A; Froeyen, M; Herdewijn, P; Michielssens, S; Tho Nguyen, M; Tien Trung, N | 1 |
| Contreras, L; Kobayashi, K; Saheki, T; Satrústegui, J; Urbieta, A | 1 |
| Mali, Y; Zisapel, N | 1 |
| Chong, WP; Heng, CK; Ho, YS; Lee, DY; Reddy, SG; Wong, NS; Yap, MG; Yusufi, FN | 1 |
| Birkler, RD; Bøtker, HE; Caldarone, CA; Contractor, H; Johannsen, M; Kristiansen, SB; Løfgren, B; Nielsen, JM; Nielsen, TT; Støttrup, NB; Wang, L | 1 |
| Barba, I; González-Loyola, A | 1 |
| Hertz, L | 1 |
| Bøtker, HE; Løfgren, B; Nielsen, TT; Støttrup, NB | 1 |
| del Rio, RM; Feldmann, N; Gjinovci, A; Tamarit-Rodriguez, J; Wiederkehr, A; Wollheim, CB | 1 |
| Banerjee, S; Lu, M; Saidel, GM; Yu, X | 1 |
| Lin, CY; Lin, WC; Tseng, YP; Yen, YP | 1 |
| Abbrescia, DI; La Piana, G; Lofrumento, NE | 1 |
| Gaynutdinov, T; Gellerich, FN; Gizatullina, Z; Heinze, HJ; Korzeniewski, B; Seppet, E; Striggow, F; Trumbekaite, S; Vielhaber, S | 1 |
| Rao, XF; Sun, SZ; Wang, DW; Wei, DB; Wei, L; Zhu, RJ | 1 |
| Bøtker, HE; Dalgas, C; Erichsen, SB; Løfgren, B; Povlsen, JA | 1 |
| Han, W; Lee, P; Leong, W; Lim, M; Radda, GK; Tan, T | 1 |
| Casarejos, MJ; Contreras, L; Dierssen, M; Grau, JM; Llorente-Folch, I; Mena, MA; Pardo, B; Saheki, T; Sahún, I; Satrústegui, J | 1 |
| Gainutdinov, T; Gellerich, FN; Gizatullina, Z; Muth, K; Orynbayeva, Z; Seppet, E; Vielhaber, S | 1 |
| Bradshaw, PC; Brito, AG; Canfield, J; Copes, N; Edwards, CB | 1 |
| Birkler, RI; Bøtker, HE; Dalgas, C; Johannsen, M; Løfgren, B; Povlsen, JA; Støttrup, NB | 1 |
| Akatsu, H; Datta, A; Heese, K; Sze, SK | 1 |
| Bakermans, AJ; Dodd, MS; Houten, SM; Nicolay, K; Prompers, JJ; Tyler, DJ | 1 |
| Bommareddy, RR; Chen, Z; Frank, D; Rappert, S; Zeng, AP | 1 |
| Li, LM; Li, N; Lin, LD; Lin, YQ; Pang, QY; Wu, QQ; Yan, XF; Zhang, AQ; Zou, HX | 1 |
| Aksentijević, D; Brookes, PS; Chouchani, ET; Costa, ASH; Dare, AJ; Davidson, SM; Duchen, MR; Eaton, S; Eyassu, F; Frezza, C; Gaude, E; Hartley, RC; Hu, CH; James, AM; Krieg, T; Logan, A; Murphy, MP; Nadtochiy, SM; Ord, ENJ; Pell, VR; Robb, EL; Robinson, AJ; Rogatti, S; Saeb-Parsy, K; Shattock, MJ; Shirley, R; Smith, AC; Sundier, SY; Work, LM | 1 |
| Banke, NH; Lewandowski, ED | 1 |
| Guan, KL; Lin, H; Ling, ZQ; Shi, Q; Xiong, Y; Yang, H; Yang, Y; Ye, D; Zhang, M; Zhao, S; Zhao, Y; Zhou, L | 1 |
| Chen, H; Ding, X; Wang, C; Wei, X; Ying, W | 1 |
| Alfonso, I; Bolte, M; Faggi, E; Fajarí, L; Gavara, R; Juliá, L; Rodríguez, L | 1 |
| Berg, IA; Borjian, F; Han, J; Hou, J; Xiang, H | 1 |
| Hamada, M; Kato, J; Nakashimada, Y; Tajima, T | 1 |
| Chen, J; Fernandez, J; Fernandez-Bueno, GA; Gusdon, AM; Mathews, CE; Wohlgemuth, S | 1 |
| Aikoh, T; Hagiwara, T; Imai, K; Ogura, K; Sawada, K; Wada, M; Yanase, M; Yokota, A | 1 |
| Amoedo, ND; De Grassi, A; Lacombe, D; Obre, E; Pierri, CL; Punzi, G; Rossignol, R | 1 |
| Chen, H; Wang, C; Wei, X; Ying, W; Zhang, J; Zhang, M | 1 |
| Herbst, EA; Holloway, GP | 1 |
| Hong, KM; Jang, H; Kang, JH; Kim, SY; Lee, C; Lee, JS; Lee, SH; Nam, B; Seong, TW; Son, J | 1 |
| Akabani, G; Aramayo, R; Clanton, RM; Wu, G | 1 |
| Ansari, IH; Burant, CF; El Azzouny, M; Jitrapakdee, S; Longacre, MJ; MacDonald, MJ; Phannasil, P; Rattanapornsompong, K | 1 |
| Hong, D; Hong, KM; Kang, JH; Kim, SY; Lee, JS; Lee, SH; Son, J; Song, J | 1 |
| Campolo, F; Gevi, F; Naro, F; Zolla, L | 1 |
| Hou, E; Liang, M; Sun, N; Tian, Z; Usa, K; Zhang, F; Zhao, C | 1 |
| He, Q; Huang, F; Li, J; Shao, Y; Wang, T; Yao, W | 1 |
| Beyrath, J; Iannetti, EF; Koopman, WJH; Smeitink, JAM; Willems, PHGM | 1 |
| Sodek, L; Vitor, SC | 1 |
| Al Khazal, FJ; Bailis, W; Bielecki, P; Canaveras, JCG; Craft, J; Flavell, RA; Jackson, R; Khan, O; Kluger, Y; Maher, LJ; Qu, R; Rabinowitz, J; Shyer, JA; Steach, HR; Zhao, J | 1 |
| Agudelo, LZ; Brazaitis, M; Cervenka, I; Dadvar, S; Ferreira, DMS; Furrer, R; Handschin, C; Izadi, M; Kamandulis, S; Ketscher, L; Lanner, JT; Ruas, JL; Venckunas, T; Zhengye, L | 1 |
| Brand-Arzamendi, K; Campeau, PM; Cao, F; Ciapaite, J; Drögemöller, BI; Gleeson, JG; Huigen, MCDG; Issa, MY; Jans, JJ; Jia, Z; Karbassi, F; Kluijtmans, LAJ; Koster, J; Li, M; Ramos, RJ; Rodenburg, RJ; Ross, CJ; Rousseau, J; Ruiter, J; Skrypnyk, C; Tarailo-Graovac, M; van der Lee, R; van Karnebeek, CDM; Verhoeven-Duif, NM; Wanders, RJA; Wang, Y; Wasserman, WW; Waterham, HR; Wen, XY; Wevers, RA; Willemsen, MAAP; Wintjes, LT; Zaki, MS | 1 |
| Contreras, L; Del Arco, A; Pardo, B; Puertas-Frías, G; Satrústegui, J | 1 |
| Altinok, O; Bowne, WB; Orynbayeva, Z; Poggio, JL; Shieh, AC; Snyder, NW; Stein, DE | 1 |
| Birkemeyer, C; Gaunitz, F; Meixensberger, J; Oppermann, H | 1 |
| Kerkhofs, M | 1 |
| Andrianova, EP; Day, CJ; Elgamoudi, BA; Hartley-Tassell, LE; King, RM; Korolik, V; Rahman, H; Shewell, LK; Zhulin, IB | 1 |
| Eisenreich, W; Fischer, W; Goebel, W; Haas, R; Lettl, C; Schindele, F; Steiner, TM | 1 |
| Andolino, C; Donkin, SS; Hursting, SD; Kiesel, VA; Lanman, NA; Sheeley, MP; Teegarden, D; Wendt, MK | 1 |
| Guo, D; He, H; Lu, Z; Luo, S; Meng, Y | 1 |
| Holeček, M | 1 |
8 review(s) available for aspartic acid and malic acid
| Article | Year |
|---|---|
Mitochondrial transmembrane proton electrochemical potential, di- and tricarboxylate distribution and the poise of the malate-aspartate cycle in the intact myocardium.
Topics: Animals; Aspartic Acid; Carboxylic Acids; Cell Compartmentation; Citric Acid Cycle; Electrochemistry; Energy Metabolism; Glutamates; Glutamic Acid; Malates; Mathematics; Mitochondria, Heart; Protons | 1986 |
Production of multifunctional organic acids from renewable resources.
Topics: Aspartic Acid; Carboxylic Acids; Citric Acid; Conservation of Natural Resources; Fermentation; Fumarates; Lactic Acid; Malates; Succinates | 1999 |
Metabolic fingerprint of ischaemic cardioprotection: importance of the malate-aspartate shuttle.
Topics: Animals; Aspartic Acid; Calcium; Energy Metabolism; Humans; Ischemic Preconditioning, Myocardial; Malates; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocardium | 2011 |
The control of brain mitochondrial energization by cytosolic calcium: the mitochondrial gas pedal.
Topics: Adenosine Diphosphate; Amino Acid Transport Systems, Acidic; Antiporters; Aspartic Acid; Calcium; Circadian Rhythm; Cytosol; Energy Metabolism; Feedback, Physiological; Humans; Intracellular Membranes; Malates; Mitochondria; Mitochondrial Membrane Transport Proteins; Neurons; Oxidative Phosphorylation; Pyruvic Acid; Suprachiasmatic Nucleus | 2013 |
AGC1/2, the mitochondrial aspartate-glutamate carriers.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Biological Transport, Active; Calcium-Binding Proteins; Cattle; Consensus Sequence; Glutamic Acid; Humans; Malates; Mice; Mitochondria; Mitochondrial Membrane Transport Proteins; Models, Molecular; NAD; Neoplasm Proteins; Organ Specificity; Organic Anion Transporters; Oxidation-Reduction; Protein Conformation; Sequence Alignment; Sequence Homology, Amino Acid | 2016 |
Control of seizures by ketogenic diet-induced modulation of metabolic pathways.
Topics: Amino Acids, Essential; Aspartic Acid; Demyelinating Diseases; Diet, Ketogenic; Epilepsy; Fatty Acids, Volatile; Humans; Ketone Bodies; Malates; Metabolic Networks and Pathways; Mitochondria; Monocarboxylic Acid Transporters; Seizures | 2017 |
Cytosolic Ca
Topics: Animals; Aspartic Acid; Calcium; Cytosol; Humans; Malates; Mitochondria; Pyruvic Acid | 2020 |
Roles of malate and aspartate in gluconeogenesis in various physiological and pathological states.
Topics: Aspartic Acid; Gluconeogenesis; Glutamates; Lactic Acid; Malates; Pyruvic Acid | 2023 |
162 other study(ies) available for aspartic acid and malic acid
| Article | Year |
|---|---|
Oxidation of cytosolic NADH by the malate-aspartate shuttle in HuH13 human hepatoma cells.
Topics: Aspartic Acid; Carcinoma, Hepatocellular; Cytosol; Humans; Kinetics; Liver Neoplasms; Malates; NAD; Oxidation-Reduction; Tumor Cells, Cultured | 1992 |
Effects of acute alcohol intoxication on gluconeogenesis and its hormonal responsiveness in isolated, perfused rat liver.
Topics: Adenine Nucleotides; Alcoholic Intoxication; Animals; Aspartic Acid; Dinoprost; Dose-Response Relationship, Drug; Ethanol; Glucagon; Gluconeogenesis; Glucose; Glutamates; Glutamic Acid; Lactates; Liver; Malates; Male; Perfusion; Phenylephrine; Pyruvates; Rats; Rats, Sprague-Dawley | 1992 |
Age-specific development of malate-aspartate shuttle in the liver and kidney of mice.
Topics: Aging; Animals; Aspartate Aminotransferases; Aspartic Acid; Kidney; Liver; Malate Dehydrogenase; Malates; Male; Mice; Mice, Inbred BALB C; Mitochondria; Mitochondria, Liver | 1992 |
Interactions between mitochondria and cytoplasm in isolated hepatocytes.
Topics: Animals; Aspartic Acid; Biological Transport; Cytoplasm; Energy Metabolism; Enzymes; Glucose; Glycolysis; Liver; Malates; Male; Mitochondria, Liver; Multienzyme Complexes; NAD; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1992 |
Operation and energy dependence of the reducing-equivalent shuttles during lactate metabolism by isolated hepatocytes.
Topics: Ammonia; Animals; Aspartic Acid; Cytoplasm; Energy Metabolism; Gluconeogenesis; Lactates; Lactic Acid; Liver; Malates; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Palmitates; Rats; Rats, Inbred Strains; Valinomycin | 1992 |
Energy conservation by succinate decarboxylation in Veillonella parvula.
Topics: Acetates; Aspartic Acid; Carboxyl and Carbamoyl Transferases; Cell Division; Decarboxylation; Energy Metabolism; Fermentation; Hydrogen; Lactates; Lactic Acid; Malates; Models, Biological; Propionates; Pyruvate Carboxylase; Succinates; Succinic Acid; Transferases; Veillonella | 1992 |
Periplasmic metabolism of glutamate and aspartate by intact Bradyrhizobium japonicum bacteroids.
Topics: Anaerobiosis; Aspartate Aminotransferases; Aspartic Acid; Biological Transport; Carbon Radioisotopes; Cytoplasm; Glutamates; Glutamic Acid; Malates; Models, Biological; Phosphoric Diester Hydrolases; Rhizobiaceae | 1990 |
Acute and chronic ethanol treatment in vivo increases malate-aspartate shuttle capacity in perfused rat liver.
Topics: Alanine; Aminooxyacetic Acid; Animals; Aspartic Acid; Biological Transport; Cytoplasm; Ethanol; Female; Glucose; Lactates; Liver; Malates; Mitochondria, Liver; NAD; Oxygen Consumption; Rats; Rats, Inbred Strains; Sorbitol; Time Factors | 1990 |
Regulation of carbon flux from amino acids into sugar phosphates in Xenopus embryos.
Topics: Amino Acids; Animals; Aspartic Acid; Carbon; Cytosol; Energy Metabolism; Female; Glutamates; Isoenzymes; Kinetics; Lactates; Malate Dehydrogenase; Malates; Mitochondria; NADP; Ovary; Ovum; Pyruvates; Sugar Phosphates; Xenopus laevis | 1990 |
End products of glutamine oxidation in MC-29 virus-induced chicken hepatoma mitochondria.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Chickens; Citric Acid Cycle; Glutamates; Glutamic Acid; Glutamine; Lactates; Lactic Acid; Liver Neoplasms, Experimental; Malates; Mitochondria, Liver; Oxidation-Reduction; Pyruvates; Pyruvic Acid | 1989 |
[The effect of composition and ionic strength of external solution on the aspartate-ammonia lyase and fumarate hydratase activity in Escherichia coli cells].
Topics: Ammonia-Lyases; Aspartate Ammonia-Lyase; Aspartic Acid; Azides; Catalysis; Cell Membrane Permeability; Chloramphenicol; Escherichia coli; Fumarate Hydratase; Fumarates; Kinetics; Malates; Osmolar Concentration; Sodium Azide; Substrate Specificity | 1989 |
The purine nucleotide cycle activity in renal cortex and medulla.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Aspartic Acid; Cytosol; Fumarates; In Vitro Techniques; Inosine Monophosphate; Kidney Cortex; Kidney Medulla; Malates; Purine Nucleotides; Rats; Rats, Inbred Strains | 1989 |
Oxidation of cytosolic NADH by the malate-aspartate shuttle in MC29 hepatoma cells.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Chickens; Cytosol; Glutamine; Lactates; Lactic Acid; Liver Neoplasms, Experimental; Malates; Mitochondria; NAD; Oxidation-Reduction; Pyruvates; Pyruvic Acid | 1989 |
Involvement of glutamate in the respiratory metabolism of Bradyrhizobium japonicum bacteroids.
Topics: Aspartic Acid; Carbon Radioisotopes; Glutamates; Glutamic Acid; Kinetics; Malates; Oxygen Consumption; Rhizobiaceae; Succinates; Succinic Acid | 1987 |
In vivo and in vitro adenosine stimulation of ethanol oxidation by hepatocytes, and the role of the malate-aspartate shuttle.
Topics: Adenosine; Animals; Aspartic Acid; Ethanol; Glutamates; Glutamic Acid; In Vitro Techniques; Liver; Malates; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1987 |
Significance of the alanine aminotransferase reaction in the formation of alpha-ketoglutarate in rat liver mitochondria.
Topics: Alanine; Alanine Transaminase; Animals; Aspartic Acid; Citrates; Citric Acid; Glutamates; Glutamic Acid; Ketoglutaric Acids; Malates; Male; Mitochondria, Liver; Oxaloacetates; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1988 |
Subcellular distribution of malate-aspartate cycle intermediates during normoxia and anoxia in the heart.
Topics: Adenine Nucleotides; Anaerobiosis; Animals; Aspartic Acid; Citrates; Citric Acid; Citric Acid Cycle; Cytosol; Glutamates; Glutamic Acid; Glutamine; Ketoglutaric Acids; Lactates; Lactic Acid; Malates; Male; Mitochondria, Heart; Myocardium; Oxygen; Phosphocreatine; Rats; Rats, Inbred Strains; Subcellular Fractions | 1988 |
Diet effects on membrane phospholipid fatty acids and mitochondrial function in BHE rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Aspartic Acid; Coconut Oil; Corn Oil; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Fatty Acids; Glycerophosphates; Malates; Male; Membrane Lipids; Mitochondria, Liver; NAD; Oils; Phospholipids; Plant Oils; Rats; Rats, Mutant Strains | 1986 |
Pyruvate carboxylase defect: metabolic studies on cultured skin fibroblasts.
Topics: Acetyl Coenzyme A; Aspartic Acid; Carbon Dioxide; Cells, Cultured; Citric Acid Cycle; Female; Fibroblasts; Glutamine; Humans; Ketoglutaric Acids; Leucine; Malates; Mitochondria; Pyruvate Carboxylase; Pyruvate Carboxylase Deficiency Disease | 1986 |
Photosynthesis in phosphoenolpyruvate carboxykinase-type C4 plants: pathways of C4 acid decarboxylation in bundle sheath cells of Urochloa panicoides.
Topics: Aspartic Acid; Chloroplasts; Decarboxylation; Kinetics; Light; Malates; Oxaloacetates; Phosphoenolpyruvate; Phosphoenolpyruvate Carboxykinase (GTP); Photosynthesis; Picolinic Acids; Poaceae; Pyruvates; Pyruvic Acid | 1988 |
Influence of the malate-aspartate shuttle on oxidative metabolism in synaptosomes.
Topics: Acetylcholine; Animals; Aspartate Aminotransferases; Aspartic Acid; Brain; Cytosol; Energy Metabolism; Glucose; Lactates; Lactic Acid; Malates; Male; Mitochondria; Oxidation-Reduction; Oxygen Consumption; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Synaptosomes | 1988 |
The purine nucleotide cycle as two temporally separated metabolic units: a study on trout muscle.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Ammonia; Animals; Aspartic Acid; Inosine Monophosphate; Malates; Models, Biological; Physical Exertion; Purine Nucleotides; Reference Values; Salmonidae; Trout | 1988 |
Aminooxyacetic acid inhibits the malate-aspartate shuttle in isolated nerve terminals and prevents the mitochondria from utilizing glycolytic substrates.
Topics: Acetates; Aminooxyacetic Acid; Animals; Aspartic Acid; Glycolysis; Guinea Pigs; In Vitro Techniques; Malates; Membrane Potentials; Mitochondria; NAD; Onium Compounds; Organophosphorus Compounds; Oxygen Consumption; Synaptosomes | 1987 |
The photorespiratory hydrogen shuttle. Synthesis of phthalonic acid and its use in the characterization of the malate/aspartate shuttle in pea (Pisum sativum) leaf mitochondria.
Topics: Aspartate Aminotransferases; Aspartic Acid; Fabaceae; Glycine; Ketoglutaric Acids; Malates; Mitochondria; Oxidation-Reduction; Oxygen Consumption; Plants, Medicinal | 1987 |
Importance of the malate-aspartate shuttle for the reoxidation of glycolytically produced NADH and for cell aggregation in porcine blood platelets.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Blood Platelets; Cytosol; Glycolysis; Malate Dehydrogenase; Malates; Mitochondria; NAD; Oxidation-Reduction; Oxygen Consumption; Platelet Aggregation; Swine; Uncoupling Agents | 1987 |
Effects of alanine on malate-aspartate shuttle in perfused livers from cold-exposed rats.
Topics: Adrenalectomy; Alanine; Alanine Transaminase; Aminooxyacetic Acid; Animals; Asparagine; Aspartic Acid; Cold Temperature; Dexamethasone; Ethanol; Glucose; Lactates; Lactic Acid; Liver; Malates; Male; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Sorbitol | 1986 |
Malate-aspartate shuttle enzymes in rat brain regions, liver and heart during alloxan diabetes and insulin replacement.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Brain; Brain Stem; Cerebellum; Diabetes Mellitus, Experimental; Insulin; Liver; Malate Dehydrogenase; Malates; Myocardium; Rats; Rats, Inbred Strains | 1985 |
The malate/aspartate shuttle and pyruvate kinase as targets involved in the stimulation of gluconeogenesis by phenylephrine.
Topics: Animals; Aspartic Acid; Biological Transport; Cytosol; Dihydroxyacetone; Ethanol; Glucagon; Gluconeogenesis; Glycerol; In Vitro Techniques; Lactates; Lactic Acid; Liver; Malates; Male; Oxidation-Reduction; Phenylephrine; Pyruvate Kinase; Rats; Rats, Inbred Strains | 1986 |
The function of redox shuttles during aerobic glycolysis in two strains of Ehrlich ascites tumor cells.
Topics: Aerobiosis; Aminooxyacetic Acid; Animals; Arsenic; Arsenites; Aspartic Acid; Carcinoma, Ehrlich Tumor; Cell Line; Citrates; Citric Acid; Female; Glucose; Glycerophosphates; Glycolysis; L-Lactate Dehydrogenase; Malates; Mice; Oxidation-Reduction; Oxygen Consumption; Rotenone | 1985 |
Synergistic inhibition of phosphoenolpyruvate carboxylase by aspartate and 2-oxoglutarate in Brevibacterium flavum.
Topics: Aspartic Acid; Bacterial Proteins; Brevibacterium; Carboxy-Lyases; Drug Synergism; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kinetics; Magnesium; Malates; Manganese; Phosphoenolpyruvate Carboxylase; Structure-Activity Relationship; Succinates; Succinic Acid | 1985 |
Dicarboxylate transport in maize mesophyll chloroplasts.
Topics: Aspartic Acid; Biological Transport, Active; Chloroplasts; Dicarboxylic Acids; Glutamates; Glutamic Acid; Ketoglutaric Acids; Kinetics; Malates; Oxaloacetates; Thermodynamics; Zea mays | 1981 |
Role of pyruvate carboxylation in the energy-linked regulation of pool sizes of tricarboxylic acid-cycle intermediates in the myocardium.
Topics: Alanine; Animals; Aspartic Acid; Bicarbonates; Citrates; Citric Acid; Citric Acid Cycle; Female; Glutamates; Glutamic Acid; Heart Arrest; In Vitro Techniques; Ketoglutaric Acids; Kinetics; Malates; Mitochondria, Heart; Myocardium; Potassium Chloride; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1982 |
Dicarboxylic amino acids shunt in mitochondria of amphibian oocytes.
Topics: Amino Acids, Dicarboxylic; Animals; Aspartate Aminotransferases; Aspartic Acid; Female; Glutamates; Glutamic Acid; Isocitrates; Malate Dehydrogenase; Malates; Mitochondria; Oocytes; Ovum; Xenopus laevis | 1983 |
Evidence for the malate aspartate shuttle in pancreatic islets.
Topics: Aminooxyacetic Acid; Animals; Aspartate Aminotransferases; Aspartic Acid; Insulin; Islets of Langerhans; Malates; Malonates; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tissue Distribution | 1982 |
Effect of adenosine on gluconeogenesis in the perfused liver of chicken and guinea-pig.
Topics: Adenosine; Animals; Aspartic Acid; Chickens; Female; Gluconeogenesis; Guinea Pigs; Humans; Lactates; Lactic Acid; Liver; Malates; Perfusion; Pyruvates; Pyruvic Acid | 1981 |
[Evolution of the content of gluconeogenic metabolites in rat liver and kidney during exercise (author's transl)].
Topics: Animals; Aspartic Acid; Bicarbonates; Female; Gluconeogenesis; Kidney; Lactates; Lactic Acid; Liver; Malates; Phosphoenolpyruvate; Phosphoenolpyruvate Carboxykinase (GTP); Physical Exertion; Rats; Rats, Inbred Strains | 1981 |
[Utilization of L-aspartate, L-malate and fumarate by Pasteurella multocida].
Topics: Aspartic Acid; Carbon Radioisotopes; Citric Acid Cycle; Fumarates; Kinetics; Malates; Pasteurella; Tritium | 1981 |
Reducing equivalent shuttles in developing porcine myocardium: enhanced capacity in the newborn heart.
Topics: Adenosine Triphosphate; Aerobiosis; Animals; Animals, Newborn; Aspartic Acid; Biological Transport; Glycerophosphates; Heart; Malates; Mitochondria, Heart; Myocardial Contraction; NAD; Oxidation-Reduction; Swine | 1995 |
Octanoate affects 2,4-dinitrophenol uncoupling in intact isolated rat hepatocytes.
Topics: 2,4-Dinitrophenol; Adenine Nucleotides; Animals; Aspartic Acid; Caprylates; Cell Separation; Dihydroxyacetone; Dinitrophenols; Electron Transport; Fatty Acids; Glucose; Lactates; Lactic Acid; Liver; Malates; Male; NAD; Oxidation-Reduction; Oxygen Consumption; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar | 1995 |
Substrate-dependent utilization of the glycerol 3-phosphate or malate/aspartate redox shuttles by Ehrlich ascites cells.
Topics: Aminooxyacetic Acid; Animals; Antimycin A; Aspartic Acid; Carcinoma, Ehrlich Tumor; Cytosol; Fructose; Glucose; Glycerophosphates; Glycolysis; Kinetics; Lactates; Malates; Mice; Mice, Inbred C57BL; NADH Dehydrogenase; Oxidation-Reduction; Rotenone | 1995 |
Industrial application of immobilized biocatalysts in Japan.
Topics: Alanine; Anti-Bacterial Agents; Aspartic Acid; Aspergillus oryzae; Bacteria; beta-Galactosidase; Biomedical Engineering; Diltiazem; Drug Industry; Enzymes, Immobilized; Fructose; Isomaltose; Japan; Lactase; Malates; Yeasts | 1995 |
Aminooxyacetic acid striatal lesions attenuated by 1,3-butanediol and coenzyme Q10.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Butylene Glycols; Coenzymes; Corpus Striatum; Dizocilpine Maleate; Ketone Bodies; Malates; Male; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Neurotransmitter Agents; Oxidative Phosphorylation; Rats; Rats, Sprague-Dawley; Rotenone; Ubiquinone | 1994 |
Effect of aspartate and glutamate on the oxoglutarate carrier investigated in rat heart mitochondria and inverted submitochondrial vesicles.
Topics: Animals; Aspartic Acid; Carrier Proteins; Glutamates; Glutamic Acid; Ketoglutaric Acids; Kinetics; Malates; Membrane Transport Proteins; Mitochondria, Heart; Rats | 1994 |
Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria.
Topics: Animals; Aspartic Acid; Calcium; Dinitrophenols; Enzyme Activation; Glutamates; Glutamic Acid; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Malates; Membrane Potentials; Mitochondria, Heart; Models, Biological; NAD; Pyruvates; Pyruvic Acid; Rats | 1994 |
The capacity of the malate-aspartate shuttle differs between periportal and perivenous hepatocytes from rats.
Topics: Alanine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Aspartic Acid; Cells, Cultured; Ethanol; Glucose; Glutamine; Kinetics; L-Lactate Dehydrogenase; Liver; Malate Dehydrogenase; Malates; Male; Methylphenazonium Methosulfate; Mitochondria, Liver; Portal System; Portal Vein; Pyruvate Kinase; Rats; Rats, Sprague-Dawley; Sorbitol | 1994 |
Effects of calcium ions on the malate-aspartate shuttle in slow-cooled boar spermatozoa.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aspartic Acid; Calcimycin; Calcium; Cold Temperature; Egtazic Acid; Ethanol; Lanthanum; Malates; Male; Sperm Motility; Spermatozoa; Swine | 1993 |
Effect of extracellular hydrogen on organic acid utilization by the ruminal bacterium Selenomonas ruminantium.
Topics: Animals; Aspartic Acid; Culture Media; Fermentation; Fumarates; Gram-Negative Bacteria; Growth Inhibitors; Hydrogen; Lactates; Lactic Acid; Malates; Rumen | 1996 |
The specificity of fumarate as a switching factor of the bacterial flagellar motor.
Topics: Aspartic Acid; Bacterial Proteins; Chemotaxis; Escherichia coli; Flagella; Fumarates; Lactic Acid; Malates; Maleates; Membrane Proteins; Methyl-Accepting Chemotaxis Proteins; Rotation; Salmonella typhimurium; Succinates; Succinic Acid | 1996 |
Purification and characterization of recombinant phosphoenolpyruvate carboxylase of Thermus sp.
Topics: Acetyl Coenzyme A; Allosteric Regulation; Aspartic Acid; Chromatography, Gel; Chromatography, Ion Exchange; Cloning, Molecular; Escherichia coli; Guanidine; Guanidines; Hydrogen-Ion Concentration; Kinetics; Malates; Molecular Weight; Phosphoenolpyruvate Carboxylase; Protein Denaturation; Recombinant Proteins; Substrate Specificity; Thermodynamics; Thermus | 1996 |
The replacement of Lys620 by serine desensitizes Escherichia coli phosphoenolpyruvate carboxylase to the effects of the feedback inhibitors L-aspartate and L-malate.
Topics: Amino Acid Sequence; Aspartic Acid; Enzyme Inhibitors; Escherichia coli; Feedback; Kinetics; Malates; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoenolpyruvate Carboxylase; Structure-Activity Relationship | 1997 |
Metabolite changes associated with heat shocked avian fibroblast mitochondria.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Citric Acid; Energy Metabolism; Fibroblasts; Fumarates; Glutamic Acid; Glycerophosphates; Glycolysis; Hot Temperature; Ketoglutaric Acids; Malates; Mitochondria; Phosphocreatine; Pyruvates; Stress, Physiological | 1997 |
Regulatory phosphorylation of plant phosphoenolpyruvate carboxylase: role of a conserved basic residue upstream of the phosphorylation site.
Topics: Asparagine; Aspartic Acid; Binding Sites; Conserved Sequence; Enzyme Activation; Enzyme Inhibitors; Glucose-6-Phosphate; Lysine; Malates; Mutagenesis, Site-Directed; Phosphoenolpyruvate Carboxylase; Phosphorylation; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Serine; Zea mays | 1997 |
Fumarate permeation in normal and acidotic rat kidney mitochondria: fumarate/malate and fumarate/aspartate translocators.
Topics: Acidosis; Adenylosuccinate Lyase; Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Fumarates; Kidney; Malates; Male; Mitochondria; NAD; NADP; Oxaloacetates; Rats; Rats, Wistar | 1998 |
Ontogeny of malate-aspartate shuttle capacity and gene expression in cardiac mitochondria.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Base Sequence; Biological Transport; DNA, Complementary; Down-Regulation; Gene Expression; Malate Dehydrogenase; Malates; Mitochondria, Heart; Molecular Sequence Data; NAD; RNA, Messenger; Swine | 1998 |
Malate-aspartate shuttle, cytoplasmic NADH redox potential, and energetics in vascular smooth muscle.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Biological Transport; Cytoplasm; Energy Metabolism; Glucose; Malates; Mitochondria, Muscle; Muscle Contraction; Muscle, Smooth, Vascular; NAD; Oxidation-Reduction; Oxygen Consumption; Phosphates; Swine | 1998 |
A novel, definitive test for substrate channeling illustrated with the aspartate aminotransferase/malate dehydrogenase system.
Topics: Arginine; Aspartate Aminotransferases; Aspartic Acid; Escherichia coli; Malate Dehydrogenase; Malates; Multienzyme Complexes; Mutagenesis, Site-Directed; Oxaloacetic Acid; Pyridoxine; Substrate Specificity | 1999 |
Inhibition of glutamine transport in rat brain mitochondria by some amino acids and tricarboxylic acid cycle intermediates.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Biological Transport; Brain; Citric Acid Cycle; Glutamic Acid; Glutamine; Ketoglutaric Acids; Kinetics; Malates; Mitochondria; Rats; Rats, Wistar; Succinic Acid | 1999 |
Mitochondrial transporter responsiveness and metabolic flux homeostasis in postischemic hearts.
Topics: Animals; Aspartic Acid; Biological Transport; Malates; Mitochondria, Heart; Myocardial Contraction; Myocardial Ischemia; Rabbits; Tricarboxylic Acids | 1999 |
Is beta-poly(L-malate) synthesis catalysed by a combination of beta-L-malyl-AMP-ligase and beta-poly(L-malate) polymerase?
Topics: Acyltransferases; Adenosine Triphosphate; Animals; Aspartic Acid; Citric Acid; Energy Metabolism; Fumarates; Ligases; Malates; Microinjections; Physarum polycephalum; Polymers | 1999 |
The oscillatory behavior of pancreatic islets from mice with mitochondrial glycerol-3-phosphate dehydrogenase knockout.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cytoplasm; Electrophysiology; Enzyme Inhibitors; Female; Glucose; Glycerolphosphate Dehydrogenase; Insulin; Insulin Secretion; Islets of Langerhans; Malates; Mice; Mice, Knockout; Mitochondria; Potassium; Time Factors | 2000 |
Evidence of enhancement of malate-aspartate shuttle activity in beta cells of streptozotocin-induced non-insulin-dependent diabetic rats.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Insulin; Islets of Langerhans; Malates; Male; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley | 2000 |
Characterization of the functional role of Asp141, Asp194, and Asp464 residues in the Mn2+-L-malate binding of pigeon liver malic enzyme.
Topics: Animals; Aspartic Acid; Base Sequence; Binding Sites; Columbidae; Dimerization; DNA Primers; Escherichia coli; Humans; In Vitro Techniques; Kinetics; Liver; Malate Dehydrogenase; Malates; Manganese; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Quaternary; Recombinant Proteins; Thermodynamics | 2000 |
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage.
Topics: Animals; Aspartic Acid; Blood Glucose; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Carrier Proteins; Cattle; Electron Transport; Electron Transport Complex II; Endothelium, Vascular; Enzyme Activation; Glycation End Products, Advanced; Hyperglycemia; Ion Channels; Malates; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Multienzyme Complexes; NF-kappa B; Oxidoreductases; Protein Kinase C; Reactive Oxygen Species; Rotenone; Sorbitol; Succinate Dehydrogenase; Superoxide Dismutase; Thenoyltrifluoroacetone; Uncoupling Agents; Uncoupling Protein 1 | 2000 |
Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury.
Topics: Adenosine Triphosphate; Aerobiosis; Anaerobiosis; Animals; Aspartic Acid; Benzimidazoles; Carbocyanines; Cell Hypoxia; Citric Acid Cycle; Energy Metabolism; Female; Fluorescent Dyes; Fumarates; Ketoglutaric Acids; Kidney Tubules, Proximal; Malates; Membrane Potentials; Mitochondria; Oxygen; Rabbits; Rhodamines; Substrate Specificity | 2000 |
Metabolic adaptation of the hypertrophied heart: role of the malate/aspartate and alpha-glycerophosphate shuttles.
Topics: Adenosine Triphosphate; Animals; Aorta; Aspartic Acid; Atrial Natriuretic Factor; Blotting, Northern; Cardiomegaly; Fatty Acids; Glucose; Glycerophosphates; Immunoblotting; Lactic Acid; Malate Dehydrogenase; Malates; Male; Mitochondria; Models, Biological; Myocardium; NAD; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 2000 |
Flux-balance analysis of mitochondrial energy metabolism: consequences of systemic stoichiometric constraints.
Topics: Adenosine Triphosphate; Aspartic Acid; Citric Acid Cycle; Energy Metabolism; Fatty Acids, Nonesterified; Flavin-Adenine Dinucleotide; Fumarate Hydratase; Gene Deletion; Glucose; Glycerophosphates; Glycolysis; Humans; Lactic Acid; Malates; Mitochondria; Models, Biological; Mutation; NAD; Oxygen Consumption; Palmitic Acid; Phosphofructokinase-1; Pyruvate Dehydrogenase Complex | 2001 |
Spatial heterogeneity of energy turnover in the heart.
Topics: Alanine; Animals; Aspartic Acid; Carbon Isotopes; Citric Acid; Citric Acid Cycle; Coronary Circulation; Dogs; Energy Metabolism; Glutamic Acid; Ketoglutaric Acids; Lactic Acid; Magnetic Resonance Spectroscopy; Malates; Models, Biological; Myocardium; Oxaloacetic Acid; Oxygen Consumption; Pyruvic Acid | 2001 |
A study into the role of L-aspartic acid on the metabolism of L-malic acid and D-glucose by Oenococcus oeni.
Topics: Aspartic Acid; Culture Media; Fermentation; Glucose; Glutamic Acid; Gram-Positive Cocci; Leuconostoc; Malates | 2001 |
Changes in activities of enzymes related to malate-aspartate shuttle in leukocytes from dogs given a herb supplement.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Blood Glucose; Dietary Supplements; Dogs; Drugs, Chinese Herbal; Fatty Acids, Nonesterified; Female; Glutamate Dehydrogenase; Insulin; L-Lactate Dehydrogenase; Leukocytes; Malate Dehydrogenase; Malates; Male; NAD; Triglycerides | 2001 |
TCA cycle kinetics in the rat heart by analysis of (13)C isotopomers using indirect (1)H.
Topics: Acetic Acid; Aminooxyacetic Acid; Animals; Aspartic Acid; Carbon Isotopes; Citric Acid Cycle; Enzyme Inhibitors; Glutamic Acid; Heart; In Vitro Techniques; Kinetics; Magnetic Resonance Spectroscopy; Malates; Models, Biological; Myocardium; Perfusion; Propionates; Rats; Transaminases | 2001 |
Influence of allosteric effectors on the kinetics and equilibrium binding of phosphoenolpyruvate (PEP) to phosphoenolpyruvate carboxylase (PEPC) from Zea mays.
Topics: Algorithms; Aspartic Acid; Enzyme Inhibitors; Fluorescent Dyes; Fluorometry; Glucose-6-Phosphate; Kinetics; Malates; Molecular Conformation; Phosphoenolpyruvate; Phosphoenolpyruvate Carboxylase; Protein Binding; Zea mays | 2001 |
Hydrocortisone and triiodothyronine regulation of malate-aspartate shuttle enzymes during postnatal development of chicken.
Topics: Animals; Anti-Inflammatory Agents; Aspartic Acid; Chickens; Cytosol; Hydrocortisone; Kidney; Liver; Malate Dehydrogenase; Malates; Male; Mitochondria; Rats; Time Factors; Triiodothyronine | 2001 |
Activities of enzymes in the malate-aspartate shuttle in the peripheral leukocytes of dogs and cats.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Blood Glucose; Cats; Cytosol; Dogs; Fatty Acids, Nonesterified; Female; Gene Expression; Glutamate Dehydrogenase; Insulin; L-Lactate Dehydrogenase; Leukocytes; Malate Dehydrogenase; Malates; Male; Mitochondria; NAD; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triglycerides | 2001 |
Molecular characterization of a phosphoenolpyruvate carboxylase from a thermophilic cyanobacterium, Synechococcus vulcanus with unusual allosteric properties.
Topics: Allosteric Regulation; Amino Acid Sequence; Aspartic Acid; Cloning, Molecular; Cyanobacteria; Escherichia coli; Fructosediphosphates; Gene Expression; Genes, Bacterial; Genomic Library; Glyceric Acids; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Malates; Molecular Sequence Data; Phosphoenolpyruvate; Phosphoenolpyruvate Carboxylase; Restriction Mapping; Sequence Homology, Amino Acid | 2002 |
Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia.
Topics: Adult; Aged; Alanine; Animals; Antipsychotic Agents; Aspartic Acid; Biogenic Polyamines; Female; Gene Expression; Gene Expression Profiling; Haloperidol; Humans; In Situ Hybridization; Logistic Models; Macaca fascicularis; Malates; Male; Middle Aged; Mitochondria; Oligonucleotide Array Sequence Analysis; Ornithine; Prefrontal Cortex; Schizophrenia; Ubiquitin | 2002 |
Conformational change in aspartate aminotransferase on substrate binding induces strain in the catalytic group and enhances catalysis.
Topics: Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Catalysis; Escherichia coli; Glycine; Hydrogen-Ion Concentration; Kinetics; Ligands; Lysine; Malates; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; N-Methylaspartate; Oxygen; Photons; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Spectrophotometry; Tyrosine; Valine | 2003 |
Activities of enzymes in the malate-aspartate shuttle and the isoenzyme pattern of lactate dehydrogenase in plasma and peripheral leukocytes of lactating Holstein cows and riding horses.
Topics: Amino Acid Oxidoreductases; Animals; Aspartic Acid; Blood Glucose; Cattle; Fatty Acids, Nonesterified; Female; Glutamate Dehydrogenase; Horses; Insulin; Isoenzymes; L-Lactate Dehydrogenase; Lactation; Malate Dehydrogenase; Malates | 2003 |
SYNTHESIS OF GLUTAMATE FROM ALPHA-OXOGLUTARATE AND AMMONIA IN RAT-LIVER MITOCHONDRIA. III. MALATE AS HYDROGEN DONOR.
Topics: Adenosine Triphosphate; Ammonia; Amobarbital; Anti-Bacterial Agents; Aspartic Acid; Dinitrophenols; Enzyme Inhibitors; Glutamates; Glutamic Acid; Hydrogen; Ketoglutaric Acids; Liver; Malates; Mitochondria; Mitochondria, Liver; NAD; Oligomycins; Pharmacology; Rats; Research | 1963 |
METABOLISM OF PROPIONATE BY SHEEP LIVER. INTERRELATIONS OF PROPIONATE AND GLUTAMATE IN AGED MITOCHONDRIA.
Topics: Acyl Coenzyme A; Aging; Amino Acids; Animals; Aspartic Acid; Carbon Dioxide; Citrates; Fatty Acids; Fumarates; Glutamates; Glutamic Acid; Ketoglutaric Acids; Liver; Malates; Mitochondria; Mitochondria, Liver; Oxaloacetates; Pharmacology; Propionates; Pyruvates; Research; Sheep; Sheep, Domestic; Succinates | 1965 |
THE UTILIZATION OF GLYCOLLATE BY MICROCOCCUS DENITRIFICANS: THE BETA-HYDROXYASPARTATE PATHWAY.
Topics: Acetates; Alcohol Oxidoreductases; Amino Acids; Aspartic Acid; Colorimetry; Fructose-Bisphosphate Aldolase; Glycine; Glycolates; Glyoxylates; Malate Dehydrogenase; Malates; Metabolism; Micrococcus; NADP; Paracoccus denitrificans; Research | 1965 |
MICROBIAL GROWTH ON C1 COMPOUNDS. SYNTHESIS OF CELL CONSTITUENTS BY METHANE- AND METHANOL-GROWN PSEUDOMONAS METHANICA.
Topics: Alanine; Alcohols; Aspartic Acid; Bicarbonates; Chromatography; Citrates; Ethanol; Fructose; Glucose; Glutamates; Glycine; Heptoses; Hexosephosphates; Malates; Metabolism; Methane; Methanol; Propionates; Pseudomonas; Research; Ribose; Serine | 1965 |
Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae.
Topics: Acetates; Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Carbon Dioxide; Glutamic Acid; Humans; Liposomes; Malates; Membrane Potentials; Mitochondria; Ornithine; Protein Isoforms; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2003 |
A (13)C isotopomer kinetic analysis of cardiac metabolism: influence of altered cytosolic redox and [Ca(2+)](o).
Topics: Animals; Aspartic Acid; Calcium; Carbon Isotopes; Citric Acid Cycle; Cytosol; Glutamic Acid; Heart Rate; Kinetics; Lactic Acid; Magnetic Resonance Spectroscopy; Malates; Male; Myocardium; Osmolar Concentration; Oxidation-Reduction; Oxygen Consumption; Pressure; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Ventricular Function, Left | 2004 |
Localization and function of the brain excitatory amino acid transporter type 1 in cardiac mitochondria.
Topics: Adenoviridae; Animals; Aspartic Acid; Blotting, Northern; Brain; Cells, Cultured; Coloring Agents; Cytochromes c; Digitonin; DNA, Complementary; Excitatory Amino Acid Transporter 1; Genetic Vectors; Glutamic Acid; Hypoxia; Immunoblotting; Immunohistochemistry; Malates; Microscopy, Fluorescence; Mitochondria; Mitochondria, Heart; Myocardium; Open Reading Frames; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Subcellular Fractions; Tetrazolium Salts; Thiazoles; Transfection | 2004 |
Krebs cycle enzymes from livers of old mice are differentially regulated by caloric restriction.
Topics: Aging; Animals; Aspartic Acid; Caloric Restriction; Citric Acid; Citric Acid Cycle; Glutamic Acid; Ketoglutaric Acids; Liver; Malates; Male; Mice; Mice, Inbred C57BL; Time Factors | 2004 |
The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells.
Topics: Adenosine Triphosphate; Adenoviridae; Animals; Aspartic Acid; Calcium; Cell Line; Cell Separation; Cells, Cultured; Cytosol; Epitopes; Flow Cytometry; Glucose; Glutamic Acid; Glycolysis; Humans; Immunoblotting; Insulin; Insulin Secretion; Islets of Langerhans; Lac Operon; Lactates; Malates; Membrane Potentials; Membrane Transport Proteins; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Models, Biological; NADP; Oxygen; Protein Isoforms; Rats; Tissue Distribution | 2004 |
Correlation between myocardial malate/aspartate shuttle activity and EAAT1 protein expression in hyper- and hypothyroidism.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Cardiomegaly; Excitatory Amino Acid Transporter 1; Gene Expression; Glutamate Plasma Membrane Transport Proteins; Hyperthyroidism; Hypothyroidism; Immunoblotting; Malates; Myocardium; Rats; Rats, Sprague-Dawley; RNA, Messenger; Symporters; Triiodothyronine | 2005 |
Mitochondrial malate-aspartate shuttle regulates mouse embryo nutrient consumption.
Topics: Animals; Aspartic Acid; Biological Transport; Embryo, Mammalian; Embryonic Development; Female; Malates; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mitochondria; Nutritional Physiological Phenomena; Organ Culture Techniques; Pregnancy | 2005 |
Alterations in the heart mitochondrial proteome in a desmin null heart failure model.
Topics: Acetic Acid; Amino Acids; Animals; Aspartic Acid; Cardiomyopathy, Dilated; Databases, Protein; Desmin; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; In Vitro Techniques; Ketone Bodies; Malates; Mice; Mice, Knockout; Mitochondria, Heart; Mitochondrial Proteins; Oxidation-Reduction; Porins; Proteome; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Voltage-Dependent Anion Channels | 2005 |
Stimulation of Erwinia sp. fumarase and aspartase synthesis by changing medium components.
Topics: Algorithms; Aspartate Ammonia-Lyase; Aspartic Acid; Biomass; Culture Media; Erwinia; Fumarate Hydratase; Fumarates; Hydrogen-Ion Concentration; Industrial Microbiology; Malates; Models, Statistical; Polyvinyl Chloride | 2005 |
Ammonia effects on pyruvate/lactate production in astrocytes--interaction with glutamate.
Topics: Ammonia; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Bucladesine; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Energy Metabolism; Glutamic Acid; Glutamine; Glutathione; Glycolysis; Hyperammonemia; Interneurons; Lactic Acid; Malates; Mice; Mitochondria; Oxidation-Reduction; Oxidative Stress; Pyruvic Acid; Up-Regulation | 2005 |
Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies.
Topics: Animals; Aspartic Acid; Computer Simulation; Cytosol; Energy Metabolism; Glycolysis; Humans; Ischemia; Kinetics; Lactic Acid; Malates; Mitochondria; Models, Biological; Myocardial Ischemia; Myocardium; NAD; Oxidation-Reduction; Oxygen Consumption | 2005 |
The regulatory role of residues 226-232 in phosphoenolpyruvate carboxylase from maize.
Topics: Aspartic Acid; Enzyme Activation; Glycine; Kinetics; Malates; Mutagenesis, Site-Directed; Phosphoenolpyruvate Carboxylase; Zea mays | 2006 |
Light-enhanced dark respiration in leaves, isolated cells and protoplasts of various types of C4 plants.
Topics: Aspartic Acid; Cell Respiration; Glycine; Malates; Oxaloacetic Acid; Oxygen; Panicum; Photosynthesis; Plant Leaves; Protoplasts; Zea mays | 2006 |
Effects of L-malate on physical stamina and activities of enzymes related to the malate-aspartate shuttle in liver of mice.
Topics: Administration, Oral; Animals; Aspartate Aminotransferase, Cytoplasmic; Aspartate Aminotransferase, Mitochondrial; Aspartic Acid; Blood Glucose; Blood Urea Nitrogen; Carrier Proteins; Citric Acid Cycle; Creatine Kinase; Cytosol; Dose-Response Relationship, Drug; Energy Metabolism; L-Lactate Dehydrogenase; Lactic Acid; Liver; Malate Dehydrogenase; Malates; Male; Mice; Mitochondria, Liver; Muscle Fatigue; Physical Endurance; Swimming | 2007 |
Action of diclofenac on kidney mitochondria and cells.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Aspartic Acid; Benzimidazoles; Carbocyanines; Cells, Cultured; Diclofenac; Dogs; Glutamate Dehydrogenase; Kidney; Malate Dehydrogenase; Malates; Membrane Potentials; Mitochondria; Mitochondrial Membranes; NADH Dehydrogenase; Oligomycins; Rats | 2006 |
Dietary restriction and triiodothyronine (T3) regulation of malate-aspartate shuttle enzymes in the liver and kidney of mice.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Caloric Restriction; Cytosol; Diet; Isoenzymes; Kidney; Liver; Malate Dehydrogenase; Malates; Male; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Triiodothyronine | 2005 |
The importance of redox shuttles to pancreatic beta-cell energy metabolism and function.
Topics: Animals; Aspartic Acid; Cytosol; Energy Metabolism; Flavin-Adenine Dinucleotide; Glucose; Glycerophosphates; Insulin; Insulin Secretion; Insulin-Secreting Cells; Malates; Mitochondria; Models, Biological; NAD; Oxidation-Reduction | 2006 |
Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Brain; Calcium; Glutamic Acid; Kinetics; Malates; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mitochondria, Heart; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Molecular Sequence Data; Muscle, Skeletal; NAD | 2007 |
Mutations in yhiT enable utilization of exogenous pyrimidine intermediates in Salmonella enterica serovar Typhimurium.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Bacterial Proteins; Base Sequence; Carrier Proteins; Cloning, Molecular; Escherichia coli; Genes, Bacterial; Malates; Membrane Proteins; Molecular Sequence Data; Mutation; Operon; Orotic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Salmonella typhimurium; Succinic Acid; Transcription Initiation Site | 2007 |
Late onset of dietary restriction reverses age-related decline of malate-aspartate shuttle enzymes in the liver and kidney of mice.
Topics: Age Factors; Animals; Aspartate Aminotransferases; Aspartic Acid; Caloric Restriction; Electrophoresis, Polyacrylamide Gel; Kidney; Liver; Malate Dehydrogenase; Malates; Male; Mice; Mice, Inbred BALB C | 2008 |
Electrochemical biomineralization: the deposition of calcite with chiral morphologies.
Topics: Aspartic Acid; Calcium Carbonate; Electroplating; Malates; Microscopy, Electron, Scanning; Tartrates | 2007 |
Malate metabolism in Hoya carnosa mitochondria and its role in photosynthesis during CAM phase III.
Topics: Apocynaceae; Aspartate Aminotransferase, Mitochondrial; Aspartic Acid; Ketoglutaric Acids; Malates; Mitochondria; Oxidation-Reduction; Oxygen Consumption; Photosynthesis; Potassium Cyanide; Pyridoxal Phosphate; Rotenone; Salicylamides | 2008 |
Gain of interaction of ALS-linked G93A superoxide dismutase with cytosolic malate dehydrogenase.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Line; Cytosol; Humans; Malate Dehydrogenase; Malates; Mice; Mice, Inbred C57BL; Neurons; Superoxide Dismutase | 2008 |
Disruption of mitochondrial malate-aspartate shuttle activity in mouse blastocysts impairs viability and fetal growth.
Topics: Aminooxyacetic Acid; Animals; Aspartate Aminotransferase, Cytoplasmic; Aspartic Acid; Biological Transport; Blastocyst; Cells, Cultured; Enzyme Inhibitors; Female; Fetal Development; Fetal Viability; Malate Dehydrogenase; Malates; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mitochondria; Pregnancy | 2009 |
Calcium signaling in brain mitochondria: interplay of malate aspartate NADH shuttle and calcium uniporter/mitochondrial dehydrogenase pathways.
Topics: Animals; Aspartic Acid; Brain; Calcium; Calcium Channels; Calcium Signaling; Cytosol; Ketoglutaric Acids; Malates; Mice; Mitochondria, Heart; Mitochondrial Proteins; NAD; Organic Anion Transporters | 2009 |
In vivo regulatory phosphorylation of the phosphoenolpyruvate carboxylase AtPPC1 in phosphate-starved Arabidopsis thaliana.
Topics: Adaptation, Physiological; Arabidopsis; Arabidopsis Proteins; Aspartic Acid; Glucose-6-Phosphate; Malates; Phosphates; Phosphoenolpyruvate Carboxylase; Phosphorylation; Transcriptional Activation | 2009 |
Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+ levels.
Topics: Animals; Antimetabolites; Aspartic Acid; Calcium; Calcium Signaling; Cells, Cultured; Cerebellum; Cytosol; Deoxyglucose; Excitatory Amino Acid Agonists; Glucose; Lactic Acid; Malates; Mice; N-Methylaspartate; Neurons; Neurotransmitter Agents; Synaptic Transmission | 2009 |
Site-directed mutagenesis, kinetic and inhibition studies of aspartate ammonia lyase from Bacillus sp. YM55-1.
Topics: Amino Acid Substitution; Asparagine; Aspartate Ammonia-Lyase; Aspartic Acid; Bacillus; Bacterial Proteins; Binding Sites; Catalysis; Catalytic Domain; Circular Dichroism; Histidine; Hydrogen-Ion Concentration; Kinetics; Lysine; Malates; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Nitro Compounds; Propionates; Protein Structure, Tertiary; Serine; Substrate Specificity; Threonine | 2009 |
Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells.
Topics: Aminooxyacetic Acid; Aspartate Aminotransferases; Aspartic Acid; Brain; Carbon Radioisotopes; Cell Compartmentation; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cytoplasm; Enzyme Inhibitors; Humans; Malates; Mitochondria; Neurons; Oxaloacetic Acid | 2009 |
Probing pyruvate metabolism in normal and mutant fibroblast cell lines using 13C-labeled mass isotopomer analysis and mass spectrometry.
Topics: Aspartic Acid; Carbon Isotopes; Cell Line; Chromatography, Liquid; Citric Acid; Citric Acid Cycle; Fibroblasts; Gas Chromatography-Mass Spectrometry; Humans; Isotope Labeling; Malates; Male; Mass Spectrometry; Mutation; Pyruvic Acid | 2009 |
Hydrolysis of aspartic acid phosphoramidate nucleotides: a comparative quantum chemical study.
Topics: Amides; Aspartic Acid; Catalytic Domain; HIV Reverse Transcriptase; Hydrolysis; Magnesium; Malates; Models, Chemical; Models, Molecular; Nucleotides; Phosphoric Acids; Quantum Theory | 2009 |
Low levels of citrin (SLC25A13) expression in adult mouse brain restricted to neuronal clusters.
Topics: Animals; Aspartic Acid; beta-Galactosidase; Biomarkers; Brain; Brain Mapping; Calcium-Binding Proteins; DNA-Binding Proteins; Food Deprivation; Genes, Reporter; Immunohistochemistry; Lac Operon; Liver; Malates; Metabolic Networks and Pathways; Mice; Mice, Knockout; Nerve Tissue Proteins; Neuroglia; Neurons; Nuclear Proteins; Organic Anion Transporters; Staining and Labeling; Up-Regulation | 2010 |
VEGF up-regulation by G93A superoxide dismutase and the role of malate-aspartate shuttle inhibition.
Topics: Aminooxyacetic Acid; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Carbon Dioxide; Cell Line, Transformed; Enzyme Inhibitors; Green Fluorescent Proteins; Hybridomas; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Malates; Metabolic Networks and Pathways; Mice; Recombinant Fusion Proteins; Superoxide Dismutase; Up-Regulation; Vascular Endothelial Growth Factor A | 2010 |
Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: overexpression of malate dehydrogenase II.
Topics: Animals; Aspartic Acid; Cell Count; Cell Culture Techniques; Cell Growth Processes; CHO Cells; Chromatography, Liquid; Cricetinae; Cricetulus; Malate Dehydrogenase; Malates; Mass Spectrometry; Metabolic Networks and Pathways; Metabolomics | 2010 |
Inhibition of the malate-aspartate shuttle by pre-ischaemic aminooxyacetate loading of the heart induces cardioprotection.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Cardiotonic Agents; Cell Respiration; Energy Metabolism; Glucose; Hemodynamics; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Malates; Male; Microdialysis; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Oxidation-Reduction; Oxygen Consumption; Perfusion; Rabbits; Rats; Rats, Wistar; Reactive Oxygen Species; Time Factors; Ventricular Function, Left; Ventricular Pressure | 2010 |
Mitochondrial metabolism revisited: a route to cardioprotection.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Cardiotonic Agents; Cell Respiration; Energy Metabolism; Glucose; Hemodynamics; Humans; Ischemic Preconditioning, Myocardial; Malates; Mitochondria, Heart; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Oxidation-Reduction; Oxygen Consumption; Reactive Oxygen Species; Ventricular Function, Left | 2010 |
Brain glutamine synthesis requires neuronal aspartate: a commentary.
Topics: Aspartic Acid; Astrocytes; Brain Chemistry; Glutamine; Humans; Ketoglutaric Acids; Malates; Neurons; Oxidation-Reduction | 2011 |
Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells.
Topics: Alanine; Animals; Aspartic Acid; Cell Membrane; Cells, Cultured; Dicarboxylic Acids; Epinephrine; gamma-Aminobutyric Acid; Glucagon; Glucagon-Secreting Cells; Glucose; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutamine; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ketoglutaric Acids; Malates; Male; Pyrrolidines; Rats; Rats, Wistar; Transcription, Genetic | 2011 |
Regulation of cytosolic and mitochondrial oxidation via malate-aspartate shuttle: an observation using dynamic ¹³C NMR spectroscopy.
Topics: Animals; Aspartic Acid; Biological Transport; Cell Respiration; Citric Acid Cycle; Cytosol; Heart; Lactates; Magnetic Resonance Spectroscopy; Malates; Male; Mitochondria; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 2011 |
Synthesis of alanine-based colorimetric sensors and enantioselective recognition of aspartate and malate anions.
Topics: Alanine; Anions; Aspartic Acid; Chromogenic Compounds; Colorimetry; Magnetic Resonance Spectroscopy; Malates; Molecular Structure; Quantum Theory; Stereoisomerism | 2011 |
Malate-aspartate shuttle and exogenous NADH/cytochrome c electron transport pathway as two independent cytosolic reducing equivalent transfer systems.
Topics: Animals; Apoptosis; Aspartic Acid; Biological Transport, Active; Cytochromes c; Electron Transport; Glutamate Dehydrogenase; Ketoglutaric Acids; Malates; Mitochondria, Liver; Mitochondrial Proteins; NAD; Oxidation-Reduction; Rats | 2012 |
Cytosolic Ca2+ regulates the energization of isolated brain mitochondria by formation of pyruvate through the malate-aspartate shuttle.
Topics: Animals; Aspartic Acid; Brain; Calcium; Cytosol; Kinetics; Malates; Mice; Mitochondria; Oxidative Phosphorylation; Pyruvic Acid | 2012 |
[Functional difference of malate-aspartate shuttle system in liver between plateau zokor (Myospalax baileyi) and plateau pika (Ochotona curzoniae)].
Topics: Adaptation, Physiological; Adenosine Triphosphate; Altitude; Animals; Aspartic Acid; Cloning, Molecular; L-Lactate Dehydrogenase; Lactic Acid; Lagomorpha; Liver; Malate Dehydrogenase; Malates; Membrane Transport Proteins; RNA, Messenger | 2012 |
Effects of fatty acids on cardioprotection by pre-ischaemic inhibition of the malate-aspartate shuttle.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Cardiotonic Agents; Fatty Acids; Glucose; Heart; Hemodynamics; Ischemic Preconditioning, Myocardial; Lactic Acid; Malates; Male; Myocardial Reperfusion Injury; Myocardium; Oxidation-Reduction; Rats; Rats, Wistar | 2012 |
In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucagon; Gluconeogenesis; Insulin Resistance; Liver; Magnetic Resonance Spectroscopy; Malates; Male; Mice; Mice, Inbred C57BL; Pyruvate Carboxylase; Pyruvic Acid | 2013 |
AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway.
Topics: Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Corpus Striatum; Dopamine; Emotions; Exploratory Behavior; Female; Hereditary Central Nervous System Demyelinating Diseases; Malates; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Diseases; Mitochondrial Membrane Transport Proteins; Motor Skills Disorders; Neural Pathways; Oxidative Stress; Pregnancy; Psychomotor Disorders; Substantia Nigra | 2013 |
Malate and fumarate extend lifespan in Caenorhabditis elegans.
Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Animals; Aspartic Acid; Caenorhabditis elegans; Citric Acid Cycle; Fumarates; Glyoxylates; Green Fluorescent Proteins; Longevity; Malates; Membrane Potential, Mitochondrial; Models, Biological; Oxidation-Reduction; Oxygen; Oxygen Consumption; RNA Interference | 2013 |
Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation.
Topics: Animals; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Glucose; Heart Function Tests; Hemodynamics; Malates; Male; Membrane Transport Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Oxidation-Reduction; Rats; Rats, Zucker; Recovery of Function | 2013 |
Quantitative clinical proteomic study of autopsied human infarcted brain specimens to elucidate the deregulated pathways in ischemic stroke pathology.
Topics: Aspartic Acid; Autopsy; Biomarkers; Brain; Brain Infarction; Brain Ischemia; Cluster Analysis; Cytosol; Female; Ferritins; Gliosis; Humans; Iron; Malates; Mitochondria; Neurons; Oxygen; Proteome; Proteomics; Static Electricity; Trypsin | 2013 |
Myocardial energy shortage and unmet anaplerotic needs in the fasted long-chain acyl-CoA dehydrogenase knockout mouse.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Animals; Aspartic Acid; Citric Acid Cycle; Disease Models, Animal; Energy Metabolism; Fasting; Glucose; Lipid Metabolism, Inborn Errors; Magnetic Resonance Spectroscopy; Malates; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Myocardium; Pyruvate Dehydrogenase Complex | 2013 |
Deregulation of feedback inhibition of phosphoenolpyruvate carboxylase for improved lysine production in Corynebacterium glutamicum.
Topics: Aspartic Acid; Carbon Isotopes; Corynebacterium glutamicum; Enzyme Inhibitors; Feedback; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Isotope Labeling; Lysine; Malates; Metabolic Engineering; Metabolic Flux Analysis; Mutant Proteins; NADP; Phosphoenolpyruvate Carboxylase; Point Mutation | 2014 |
Behavior of the edible seaweed Sargassum fusiforme to copper pollution: short-term acclimation and long-term adaptation.
Topics: Acclimatization; Adaptation, Physiological; Aspartic Acid; Choline; Copper; Ecosystem; Environmental Pollution; Humans; Malates; Mannitol; Metabolomics; Metals, Heavy; Nitrogen; Photosynthesis; Sargassum; Stress, Physiological | 2014 |
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Topics: Adenosine Monophosphate; Animals; Aspartic Acid; Citric Acid Cycle; Disease Models, Animal; Electron Transport; Electron Transport Complex I; Fumarates; Ischemia; Malates; Male; Metabolomics; Mice; Mitochondria; Myocardial Infarction; Myocardium; Myocytes, Cardiac; NAD; Reactive Oxygen Species; Reperfusion Injury; Stroke; Succinate Dehydrogenase; Succinic Acid | 2014 |
Impaired cytosolic NADH shuttling and elevated UCP3 contribute to inefficient citric acid cycle flux support of postischemic cardiac work in diabetic hearts.
Topics: Animals; Aspartic Acid; Carbon-13 Magnetic Resonance Spectroscopy; Carrier Proteins; Citric Acid Cycle; Cytosol; Diabetes Mellitus, Experimental; Hemodynamics; Ion Channels; Malates; Male; Mice, Inbred C57BL; Mitochondrial Proteins; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; NAD; Oxidation-Reduction; Perfusion; PPAR alpha; Uncoupling Protein 2; Uncoupling Protein 3 | 2015 |
SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth.
Topics: Acetylation; Animals; Aspartate Aminotransferase, Mitochondrial; Aspartic Acid; Biological Transport; Carcinoma, Pancreatic Ductal; Cell Proliferation; Cells, Cultured; HEK293 Cells; Humans; Malates; Male; Mice; Mice, Inbred C57BL; Mice, Nude; NAD; Oxidation-Reduction; Pancreatic Neoplasms; Protein Processing, Post-Translational; Sirtuin 3 | 2015 |
Malate-Aspartate Shuttle Inhibitor Aminooxyacetate Acid Induces Apoptosis and Impairs Energy Metabolism of Both Resting Microglia and LPS-Activated Microglia.
Topics: 4-Aminobutyrate Transaminase; Adenosine Triphosphate; Aminooxyacetic Acid; Animals; Apoptosis; Aspartic Acid; Calcium; Caspase 3; Cell Survival; Cytosol; Energy Metabolism; Enzyme Inhibitors; L-Lactate Dehydrogenase; Lipopolysaccharides; Macrophage Activation; Malates; Mice; Microglia; Mitochondria | 2015 |
Copper(ii) complexes of macrocyclic and open-chain pseudopeptidic ligands: synthesis, characterization and interaction with dicarboxylates.
Topics: Aspartic Acid; Coordination Complexes; Copper; Ligands; Malates; Spectrophotometry, Ultraviolet; X-Ray Diffraction | 2015 |
The methylaspartate cycle in haloarchaea and its possible role in carbon metabolism.
Topics: Acetates; Acetyl Coenzyme A; Archaea; Archaeal Proteins; Aspartic Acid; Carbon; Glyoxylates; Malates; Oxidation-Reduction | 2016 |
Efficient aspartic acid production by a psychrophile-based simple biocatalyst.
Topics: Aspartate Ammonia-Lyase; Aspartic Acid; Biocatalysis; Biotechnology; Enzyme Stability; Equipment Reuse; Escherichia coli; Fumarate Hydratase; Fumarates; Hot Temperature; Malates; Shewanella | 2015 |
Respiration and substrate transport rates as well as reactive oxygen species production distinguish mitochondria from brain and liver.
Topics: Animals; Aspartic Acid; Biological Transport; Brain; Cell Respiration; Dicarboxylic Acid Transporters; Electron Transport Chain Complex Proteins; Enzyme Inhibitors; Gene Expression Regulation; Glutamic Acid; Kinetics; Liver; Malates; Membrane Potential, Mitochondrial; Mice; Mitochondria, Liver; NAD; Organ Specificity; Reactive Oxygen Species; Succinic Acid | 2015 |
Pyruvate kinase deletion as an effective phenotype to enhance lysine production in Corynebacterium glutamicum ATCC13032: Redirecting the carbon flow to a precursor metabolite.
Topics: Aspartic Acid; Benzoquinones; Carbon; Citrate (si)-Synthase; Corynebacterium glutamicum; Feedback, Physiological; Gene Deletion; Lysine; Malates; Mutant Proteins; Oxaloacetic Acid; Oxidoreductases; Phenotype; Phosphoenolpyruvate Carboxylase; Pyruvate Kinase | 2016 |
Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis.
Topics: Adenosine Triphosphate; Aminooxyacetic Acid; Animals; Antineoplastic Agents; Apoptosis; Aspartic Acid; Astrocytes; Biological Transport; Cell Line, Tumor; Dose-Response Relationship, Drug; Down-Regulation; G1 Phase Cell Cycle Checkpoints; Glioma; Glycolysis; Malates; Membrane Transport Modulators; Membrane Transport Proteins; Necrosis; Primary Cell Culture; Rats; Signal Transduction | 2016 |
Exercise increases mitochondrial glutamate oxidation in the mouse cerebral cortex.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Cerebral Cortex; Glutamate Dehydrogenase; Glutamic Acid; Ketoglutaric Acids; Malates; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxygen Consumption; Physical Conditioning, Animal | 2016 |
Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion.
Topics: Action Potentials; Adenosine Triphosphate; Aldehyde Dehydrogenase; Animals; Aspartic Acid; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cytosol; Female; Gossypol; Humans; Lung Neoplasms; Malates; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; NAD; NADP; Neoplasm Transplantation; Oxidative Phosphorylation; Oxidoreductases Acting on CH-NH Group Donors; Phenformin; RNA, Small Interfering | 2016 |
Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells.
Topics: Acetyl Coenzyme A; Aspartic Acid; Biosynthetic Pathways; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Citric Acid; Female; Gene Knockdown Techniques; Glycine; Glycolysis; Humans; Lactic Acid; Malates; Mass Spectrometry; Metabolic Networks and Pathways; Neoplasm Invasiveness; Nucleotides; Pyruvate Carboxylase; Pyruvic Acid; Serine | 2017 |
Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC.
Topics: A549 Cells; Adenosine Triphosphate; Animals; Aspartic Acid; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Death; Cell Proliferation; Cell Survival; Cytosol; Drug Synergism; Fluorouracil; Gene Knockdown Techniques; Glutamic Acid; Glutaminase; Glutamine; Lung Neoplasms; Malates; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; NAD; Oxidation-Reduction; Sulfides; Thiadiazoles; Thymidylate Synthase; Xenograft Model Antitumor Assays | 2016 |
The cardioprotective effect of sildenafil is mediated by the activation of malate dehydrogenase and an increase in the malate-aspartate shuttle in cardiomyocytes.
Topics: Animals; Aspartic Acid; Benzophenanthridines; Cardiotonic Agents; Cell Line, Tumor; Citric Acid Cycle; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Fluoresceins; Glucose; Glycolysis; Malate Dehydrogenase; Malates; Mice; Myocytes, Cardiac; Pentose Phosphate Pathway; Peptide Fragments; Protein Kinase C; Sildenafil Citrate | 2017 |
Malate and Aspartate Increase L-Arginine and Nitric Oxide and Attenuate Hypertension.
Topics: Animals; Arginine; Aspartic Acid; Down-Regulation; Fumarate Hydratase; Gene Knockdown Techniques; Hypertension; Kidney; Malates; Nitric Oxide; Rats, Inbred Dahl | 2017 |
Acetyl-CoA from inflammation-induced fatty acids oxidation promotes hepatic malate-aspartate shuttle activity and glycolysis.
Topics: Acetyl Coenzyme A; Acetylation; Animals; Aspartate Aminotransferase, Mitochondrial; Aspartic Acid; Carbon Isotopes; Fatty Acids; Glycolysis; Inflammation; Lactic Acid; Lipopolysaccharides; Liver; Malate Dehydrogenase; Malates; Mitochondria, Liver; Oxidation-Reduction; Palmitic Acid; Pyruvic Acid; Stress, Physiological; Sus scrofa; Swine | 2018 |
Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD
Topics: Adenosine Triphosphate; Aspartic Acid; Cell Death; Culture Media; Electron Transport Complex I; Fibroblasts; Galactose; Gene Expression; Glycolysis; Humans; Ketoglutaric Acids; Leigh Disease; Malates; Mitochondria; Mitochondrial Diseases; Mutation; NAD; NADH Dehydrogenase; Oxaloacetic Acid; Primary Cell Culture; Pyruvic Acid; Skin | 2018 |
Products of anaerobic metabolism in waterlogged roots of soybean are exported in the xylem.
Topics: Anaerobiosis; Aspartic Acid; Citric Acid Cycle; Gas Chromatography-Mass Spectrometry; Glycine max; Lactic Acid; Malates; Plant Roots; Succinic Acid; Water; Xylem | 2019 |
Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function.
Topics: Acetylation; Animals; Aspartic Acid; Cell Differentiation; Cell Line; Cell Proliferation; Citric Acid; Citric Acid Cycle; Electron Transport; Female; Histones; Humans; Lymphocyte Activation; Malates; Male; Mice; Mitochondria; Succinate Dehydrogenase; Th1 Cells; Transcription, Genetic | 2019 |
Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance.
Topics: Adaptation, Physiological; Animals; Aspartate Aminotransferases; Aspartic Acid; Carbidopa; Cell Respiration; Energy Metabolism; Fatigue; Glycolysis; Kynurenine; Malates; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Models, Animal; Muscle, Skeletal; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Physical Conditioning, Animal; Protein Isoforms; Transaminases | 2019 |
Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy.
Topics: Alleles; Animals; Aspartic Acid; Brain Diseases; Child; Child, Preschool; Exome Sequencing; Fatty Acid-Binding Proteins; Female; Gene Knockdown Techniques; HEK293 Cells; Humans; Malates; Male; Mice; Mutation | 2019 |
Mitochondrial movement in Aralar/Slc25a12/AGC1 deficient cortical neurons.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aggrecans; Animals; Aspartic Acid; Biological Transport, Active; Calcium; Cerebral Cortex; Glycolysis; Immunohistochemistry; Malates; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial Membrane Transport Proteins; Neurons; Oxidative Phosphorylation; Pyruvic Acid | 2019 |
Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria.
Topics: Aspartic Acid; Colonic Neoplasms; HCT116 Cells; Homeostasis; Humans; Lactic Acid; Malates; Mitochondria; NAD; Oxidation-Reduction; Oxidative Phosphorylation; Warburg Effect, Oncologic | 2020 |
Non-enzymatic reaction of carnosine and glyceraldehyde-3-phosphate accompanies metabolic changes of the pentose phosphate pathway.
Topics: Adenosine Triphosphate; Aspartic Acid; Carnosine; Cell Line, Tumor; Cell Proliferation; Glucose; Glyceraldehyde; Glyceraldehyde 3-Phosphate; Glycolysis; Humans; Malates; Mitochondria; Pentose Phosphate Pathway; Phosphates | 2020 |
The
Topics: Amino Acid Sequence; Arginine; Aspartic Acid; Bacterial Proteins; Binding Sites; Caco-2 Cells; Campylobacter jejuni; Chemotaxis; Fucose; Fumarates; Galactose; HCT116 Cells; Humans; Isoleucine; Ligands; Malates; Mannose; Phylogeny; Protein Domains; Receptors, Cell Surface; Sequence Alignment; Signal Transduction; Thiamine; Virulence | 2021 |
Substrate usage determines carbon flux via the citrate cycle in Helicobacter pylori.
Topics: Acetyl Coenzyme A; Amino Acids; Aspartic Acid; Carbohydrate Metabolism; Carbon; Carbon Cycle; Citric Acid; Citric Acid Cycle; Glucose; Glutamic Acid; Glyceraldehyde; Glyoxylates; Helicobacter Infections; Helicobacter pylori; Humans; Malates; Metabolic Networks and Pathways; Succinic Acid | 2021 |
1α,25-dihydroxyvitamin D reduction of MCF10A-ras cell viability in extracellular matrix detached conditions is dependent on regulation of pyruvate carboxylase.
Topics: Aspartic Acid; Cell Survival; Doxycycline; Extracellular Matrix; Glucose; Glutamic Acid; Glutamine; Malates; Pyruvate Carboxylase; RNA, Messenger; RNA, Small Interfering; Vitamin D | 2022 |
Determiners of cell fates: the tricarboxylic acid cycle versus the citrate-malate shuttle.
Topics: Aspartic Acid; Citrates; Citric Acid; Citric Acid Cycle; Malates | 2023 |