aspartic acid has been researched along with glutamic acid in 4358 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 828 (19.00) | 18.7374 |
| 1990's | 1230 (28.22) | 18.2507 |
| 2000's | 1326 (30.43) | 29.6817 |
| 2010's | 828 (19.00) | 24.3611 |
| 2020's | 146 (3.35) | 2.80 |
| Authors | Studies |
|---|---|
| Calligaro, DO; Heinz, LJ; Lunn, WH; O'Malley, PJ; Salhoff, CR; Schoepp, DD; Vasileff, RT | 1 |
| Bigge, CF; Drummond, JT; Humblet, C; Johnson, G; Malone, TC; Ortwine, DF; Pinter, GW | 1 |
| Akamatsu, M; Asao, M; Fujita, T; Iwamura, H | 1 |
| Barrio, JR; Baumgartner, FJ; Henze, E; Kuhl, DE; MacDonald, NS; Phelps, ME; Schelbert, HR | 1 |
| Bräuner-Osborne, H; Ebert, B; Krogsgaard-Larsen, P; Nakanishi, S; Sekiyama, N; Skjaerbaek, N; Sløk, FA | 1 |
| Kinoshita, H; Shimizu, K | 1 |
| Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H | 1 |
| Boudker, O; Gouaux, E; Ryan, RM; Shimamoto, K; Yernool, D | 1 |
| Bonini, BM; Thevelein, JM; Van Zeebroeck, G; Versele, M | 1 |
| Honda, T; Izumi, T; Murai, T; Takakusa, H | 1 |
| Bunch, L; Fu, H; Jensen, AA; Poelarends, GJ; Tepper, PG; Zhang, J | 1 |
| Anthony, A; Augustyn, E; Bauer, J; Campbell, J; Chien, HC; Colas, C; Finke, K; Flint, A; Fotiadis, D; Giacomini, KM; Hall, C; Hansen, L; Heeren, N; Hernandez, C; Schlessinger, A; Springer, S; Stoner, L; Thomas, AA; Venteicher, B; Zur, AA | 1 |
| Carpenter, MB; Guha, N; Periera, AB | 1 |
| Beal, MF; Finn, SF; Kowall, NW; Mazurek, MF; Storey, E | 1 |
| Piotrovskiĭ, LB | 1 |
| Miura, M; Okada, J | 1 |
| Banderali, U; Roy, G | 1 |
| Ackerman, Z; Farrow, NA; Kreis, R; Ross, BD | 1 |
| Waniewski, RA | 1 |
| Gallo, V; Giovannini, C; Levi, G | 1 |
| Amin, S; Leitner, M; Rosenberg, PA | 1 |
| Dierks, T; Krämer, R; Salentin, A; Stappen, R | 1 |
| Haga, K; Kimura, K; Kuwano, K; Nakamura, A; Ogawa, S; Yamane, K | 1 |
| Andersson, H; Bakker, E; von Heijne, G | 1 |
| Berteloot, A; Breton, S; Chenu, C; Maenz, DD | 1 |
| Cattano, C; Nissim, I; Yudkoff, M | 1 |
| Brzović, PS; Dunn, MF; Kayastha, AM; Miles, EW | 1 |
| Krippahl, G; Lanyi, JK; Oesterhelt, D; Tittor, J; Váró, G | 1 |
| Carbone, S; Moguilevsky, JA; Otero Losada, ME; Szwarcfarb, B | 1 |
| Crespeau, H; Ferri, G; Galliano, M; Minchiotti, L; Porta, F; Rochu, D; Stoppini, M | 1 |
| Hajnal, A; Huber, M; Jackman, MP; Lerch, K | 1 |
| O'Regan, MH; Perkins, LM; Phillis, JW; Simpson, RE | 2 |
| Li, ZW; Taube, H | 1 |
| Kurtz, HJ; Larson, AA; Skilling, SR; Sun, X | 1 |
| Neale, JH; Williamson, LC | 1 |
| Ansari, S; Gupta, P; Mahanty, SK; Prasad, R | 1 |
| Coghlan, VM; Vickery, LE | 1 |
| Blake, WT; Cook, RK; Rubenstein, PA | 1 |
| Kubota, M; Saito, N; Sakaguchi, H | 1 |
| Fernandez, EJ; Higuchi, T; Maudsley, AA; Weiner, MW | 1 |
| Hanstock, CC; Novotny, EJ; Petroff, OA; Prichard, JW; Rothman, DL; Shulman, RG | 1 |
| Piek, T; Schluter, NC; Van Marle, J; Van Weeren-Kramer, J | 1 |
| Chillemi, F; Rubino, FM; Zecca, L | 1 |
| Murthy, CR; Rao, VL | 4 |
| Janáky, R; Oja, SS; Varga, V | 1 |
| Backes, MG; Sved, AF | 1 |
| Grabb, MC; Roche, FM; Sciotti, VM; Van Wylen, DG | 1 |
| Janjua, NA; Kabuto, H; Mori, A | 1 |
| Dauth, J; Nkhumeleni, FS; Pitout, MJ; Raubenheimer, EJ; Smith, PD; van Heerden, WF | 1 |
| Malaisse, WJ; Perales, MA; Sener, A | 1 |
| Boulu, RG; Callebert, J; Lekieffre, D; Plotkine, M | 1 |
| Bachurin, SO; Drany, OA; Petrova, LN; Solyakov, LS | 1 |
| Botscheller, M; Palmer, AM; Reiter, CT | 1 |
| Klunk, WE; McClure, RJ; Moossy, J; Panchalingam, K; Pettegrew, JW | 1 |
| Boulu, RG; Buisson, A; Callebert, J; Mathieu, E; Plotkine, M | 1 |
| Deakin, JF; Royston, MC; Simpson, MD; Slater, P | 1 |
| Aquila, WJ; During, MJ; Ley, E; Tendler, D; Young, RS | 1 |
| Majors, A; Modic, MT; Ng, TC; Xue, M | 1 |
| Cuénod, M; Do, KQ; Gähwiler, BH; Jiang, ZP; Klancnik, JM | 1 |
| Blanchard, JC; Doble, A; Hubert, JP | 1 |
| Okada, Y; Sakurai, T | 1 |
| Hatase, O; Hosokawa, K; Itano, T; Janjua, NA; Matsui, H; Minamoto, Y; Murakami, TH; Negi, T; Okada, Y; Tokuda, M | 1 |
| Akaike, N; Ebihara, S; Shirasaki, T; Takishima, T | 1 |
| Rekling, JC | 1 |
| Abarca, J; Bradberry, CW; Bustos, G; Forray, MI; Gysling, K; Roth, RH | 1 |
| Hauglie-Hanssen, E; Haugstad, TS; Hegstad, E; Langmoen, IA | 1 |
| Chuang, DM; Gao, XM; Paul, SM | 1 |
| Hansson, E; Nilsson, M; Rönnbäck, L | 1 |
| Ariciŏglu, F; Dizdar, Y; Esin, Y; Koyuncuŏglu, H; Uresin, Y | 1 |
| Fernández-Sánchez, MT; Kispert, J; Novelli, A; Torreblanca, A; Zitko, V | 1 |
| Feldtrauer, JJ; Stöcklin, K; Waldmeier, PC | 1 |
| Lane, JD | 1 |
| Rupitz, K; Trimbur, D; Warren, RA; Withers, SG | 1 |
| Berry, MN; Gregory, RB; Phillips, JW | 1 |
| Aschner, M; Gannon, M; Kimelberg, HK | 1 |
| Hamada, T; Hamahashi, T; Itoh, T; Kamisaki, Y; Maeda, K | 1 |
| Dolly, JO; Foran, P; McMahon, HT; Nicholls, DG; Verhage, M; Wiegant, VM | 1 |
| Hirsch, B; Jarry, H; Leonhardt, S; Wuttke, W | 1 |
| Andreeva, N; Cragoe, E; Khodorov, B; Sokolova, S; Stelmashook, E; Victorov, I | 1 |
| Matsumoto, M; Scheller, MS; Strnat, MA; Zornow, MH | 1 |
| D'Souza, NB; Deaciuc, IV; Lang, CH; Spitzer, JJ | 1 |
| Bixler, MA; Coyle, JT; Koller, KJ; Meyerhoff, JL; Robinson, MB | 1 |
| Brodin, E; Herrera-Marschitz, M; Hökfelt, T; Meana, JJ; Morino, P; Ungerstedt, U; You, ZB | 1 |
| Kus, L; McNulty, JA; Ottersen, OP | 1 |
| Martin, D; Swartzwelder, HS | 1 |
| Benoiton, NL; Chen, FM | 1 |
| Campion, SR; Niyogi, SK; Tadaki, DK | 1 |
| Coyle, JT; Tasker, RC; Vornov, JJ | 1 |
| Eguchi, T; Hirabayashi, H; Morimoto, T; Nakase, H; Sakaki, T; Tada, T | 3 |
| Balcar, VJ; Li, Y | 2 |
| Bishop, GA; King, JS | 1 |
| Dean, DR; Howard, JB; Wolle, D | 1 |
| Akatsuka, H; Hata, Y; Katsube, Y; Ko, EP; Moriyama, H; Okada, H; Shinmyo, A; Urabe, I | 1 |
| Andrews, RK; Berndt, MC; Booth, WJ; Castaldi, PA; Mazurov, AV; Ward, CM | 1 |
| Bröer, A; Dierks, T; Krämer, R; Stappen, R | 1 |
| Abe, E; Itoh, T; Masuda, Y; Murai, S; Saito, H | 1 |
| Banay-Schwartz, M; Lajtha, A; Palkovits, M | 1 |
| B'erg, A; Batuev, AS; Kharaziia, VN; Ottersen, DP; Rinvik, E; Suderevskaia, EI | 1 |
| Barrere, B; Beloeil, JC; Berenger, G; Fedeli, O; Gillet, B; Peres, M; Seylaz, J | 1 |
| Alexiev, U; Greenhalgh, DA; Heyn, MP; Khorana, HG; Otto, H; Subramaniam, S | 1 |
| Saijo, T; Tanaka, K; Vockley, J; Yokota, I | 1 |
| Chizhmakov, IV; Jackson, H; Kiskin, NI; Krishtal, OA; Mueller, AL | 1 |
| Sluka, KA; Westlund, KN | 2 |
| Ikeda, K; Iwasaki, Y; Kinoshita, M; Shiojima, T | 1 |
| Belhage, B; Hansen, GH; Kater, SB; Rehder, V; Schousboe, A | 1 |
| Greene, LW; Wu, G | 1 |
| Kumashiro, S; Kurumaji, A; Semba, J; Toru, M; Watanabe, A | 1 |
| Berg, M; Bruhn, T; Cobo, M; Diemer, NH | 1 |
| Ono, S; Yamauchi, M | 1 |
| Cazalets, JR; Clarac, F; Sqalli-Houssaini, Y | 1 |
| Gooday, GW; Milewski, S; O'Donnell, RW | 1 |
| Abdullah, LH; Ordronneau, P; Petrusz, P | 2 |
| Barbeito, L; Chéramy, A; Glowinski, J; Godeheu, G | 1 |
| Erecinska, M; Hertz, L; Nissim, I; Pleasure, D; Yudkoff, M | 1 |
| Antonelli, T; Beani, L; Bianchi, C; Calo, G; Tomasini, C; Vedovato, M | 1 |
| Osen, KK; Ottersen, OP; Usami, S; Zhang, N | 1 |
| Iino, T; Katsura, M; Kuriyama, K | 1 |
| Harata, K; Hayashi, Y; Jigami, Y; Muraki, M | 1 |
| Deckwer, WD; Hopf, NW; Yonsel, S | 1 |
| Pittaluga, A; Raiteri, M | 1 |
| Bernath, S | 1 |
| Attwell, D; Miller, B; Sarantis, M; Traynelis, SF | 1 |
| Inokuchi, H; Nishi, S; Polosa, C; Yamada, S; Yoshimura, M | 1 |
| Fain, GL; Yazejian, B | 1 |
| Amaral, DG; Insausti, R | 1 |
| Arvidsson, U; Hökfelt, T; Nicholas, AP; Pieribone, VA | 1 |
| Fuller, TA; Price, JL; Ray, JP; Russchen, FT | 1 |
| Cavanagh, ME; Dinopoulos, A; Dori, I; Parnavelas, JG | 1 |
| Blin, O; Dusticier, N; Nieoullon, A; Samuel, D | 1 |
| Blazynski, C; Linn, DM; Massey, SC; Redburn, DA | 1 |
| Beal, MF; Finn, SF; Kowall, NW; Mazurek, MF; Swartz, KJ | 1 |
| Gallo, V; Levi, G; Patrizio, M | 2 |
| Field, CJ; Marliss, EB; Wu, GY | 2 |
| Black, IB; Cohen-Cory, S; Dreyfus, CF | 1 |
| Flavin, HJ; Seyfried, TN; Wieraszko, A | 1 |
| Hamahashi, T; Itoh, T; Kamisaki, Y; Mita, C | 1 |
| Buscher, HP; Häussinger, D; McNelly, S; Stoll, B | 1 |
| Hreniuk, S; LaNoue, KF; Scaduto, RC; Sterniczuk, A | 1 |
| Bowe, MA; Bray, SD; Bustos, GA; Martin, D; Nadler, JV | 1 |
| Bullock, R; Butcher, SP; Chen, MH; Kendall, L; McCulloch, J | 1 |
| Little, HJ | 1 |
| Baruah, S; Davidson, AT; Hegwood, TS; Sherman, AD; Waziri, R | 1 |
| Das, DK; Engelman, RM; Flack, JE; Iyengar, J; Kimura, Y; Rousou, JA | 1 |
| Erecińska, M; Lin, ZP; Nelson, D; Nissim, I; Yudkoff, M | 1 |
| Damron, DS; Dorman, RV; Gannon, RL; Terrian, DM | 1 |
| Fujishima, M; Hirano, M; Matsumoto, T; Ooboshi, H; Sadoshima, S; Uchimura, H; Yao, H | 1 |
| Kuramoto, K; Nishimura, S; Sorimachi, M | 1 |
| Altekar, W; Rajagopalan, R | 1 |
| Bustos, G; Fiedler, J | 1 |
| Marini, A; Novelli, A | 1 |
| Attwell, D; Barbour, B; Brew, H | 1 |
| Gallman, EA; Lawing, WL; Millhorn, DE | 1 |
| Behar, KL; Ogino, T | 1 |
| De Biasi, S; Phend, K; Rustioni, A; Tracey, DJ | 1 |
| van den Pol, AN | 1 |
| Kirsch, JF; Toney, MD | 1 |
| Abramets, II; Komissarov, IV; Samoĭlovich, IM | 1 |
| Phillis, JW; Simpson, RE; Walter, GA | 1 |
| Brini, CM; Cyr, DM; Egan, SG; Tremblay, GC | 1 |
| Bovée, WM | 1 |
| Bruhn, H; Frahm, J; Gyngell, ML; Hänicke, W; Merboldt, KD; Michaelis, T | 1 |
| Carter, AJ; Müller, RE | 1 |
| Fletcher, EJ; Johnston, GA | 1 |
| Buckberg, GD; Matheis, G; Tixier, D; Young, HH | 1 |
| Hansson, E; Rönnbäck, L | 1 |
| Wright, HT | 1 |
| Bruhn, H; Frahm, J; Gyngell, ML; Hänicke, W; Hörstermann, D; Merboldt, KD; Michaelis, T | 1 |
| Huether, G; Lajtha, A | 1 |
| Jeftinija, K; Jeftinija, S; Larson, AA; Liu, F; Skilling, SR; Smullin, DH | 1 |
| Alesiani, M; Cherici, G; Moroni, F; Pellegrini-Giampietro, DE | 1 |
| Kauppinen, RA; Williams, SR | 1 |
| Chaudhry, V; Clawson, L; Cornblath, DR; Coyle, JT; Drachman, DB; Kuncl, R; Rothstein, JD | 1 |
| Caffrey, MS; Cusanovich, MA | 1 |
| Der Garabedian, PA; Mirambeau, G; Vermeersch, JJ | 1 |
| Campione, AL; Mann, DF; Van Winkle, LJ; Weimer, BD | 1 |
| Akoev, G; Andrianov, GN; Bromm, B; Szabo, T | 1 |
| Ohtani, S; Yamamoto, K | 1 |
| Codner, D; Drover, S; Gamberg, J; Hutchings, L; Marshall, WH | 1 |
| Mock, WL; Zhuang, H | 1 |
| Hsu, CH; Matthews, JC; Morris, KR | 1 |
| Kangrga, I; Randić, M | 2 |
| Donnerer, J | 1 |
| Attwell, D; Barbour, B; Szatkowski, M | 1 |
| Coyle, JT; Hedreen, JC; Kuncl, R; Rothstein, JD; Sim, L; Stauch-Slusher, B; Tsai, GC | 1 |
| Bhuta, S; Chang, P; Drinkwater, DC; Laks, H; Permut, LC; Stein, DG; Wu, A | 1 |
| Ernst, T; Hennig, J | 1 |
| Bishop, GA | 3 |
| Castorina, C; Cicirata, F; Di Giacomo, C; Gambera, G; Meli, C; Serapide, MF; Sorrenti, V; Vanella, A | 1 |
| Baig, S; Halawa, I; Qureshi, GA | 1 |
| Cananzi, AR; D'Andrea, G; Ferro Milone, F; Grunfeld, S; Joseph, R; Morra, M; Welch, KM; Zamberlan, F | 1 |
| Li, Y; Man, WJ; O'Connor, CD; Wilton, DC | 1 |
| Howe, R; Kai-Kai, MA | 1 |
| Erecińska, M; Nelson, D; Osbakken, M; Zhang, DN | 1 |
| Bagust, J; Gardner, CR; Hussain, S; Walker, RJ | 1 |
| Oja, SS; Saransaari, P | 5 |
| Hederstedt, L; Saraste, M; van der Oost, J; von Wachenfeld, C | 1 |
| Embery, G; Waddington, RJ | 1 |
| Burian, M; Cartellieri, M; Gstoettner, W; Wutschitz, C | 1 |
| Dumpis, MA; Kiskin, NI; Krishtal, OA; Piotrovsky, LB | 1 |
| Du, F; Schwarcz, R | 1 |
| Jiang, MC; Kangrga, I; Randić, M | 1 |
| Adams, RN; Cammack, J; Ghasemzadeh, B | 1 |
| Bettucci, D; Cantello, R; Gianelli, M; Mutani, R | 1 |
| Chapman, A; Meldrum, B | 1 |
| Dutton, GR; Philibert, RA; Rogers, KL | 1 |
| Chang, LJ; Deck, J; el-Awar, M; Gilbert, J; Kish, SJ; Robitaille, Y; Schut, L | 1 |
| Hertz, L; Juurlink, BH; Peng, LA | 1 |
| Fisher, RS | 1 |
| Hentschel, D; Huk, W; Ladebeck, R; Neundörfer, B; Schuierer, G; Schüler, P; Stefan, H; Wittig, R | 1 |
| Rios, C; Santamaria, A | 1 |
| Coraim, FI; Kassal, H; Owen, A; Trubel, W; Widhalm, K | 1 |
| Annels, SJ; Davies, JA; Ellis, Y | 1 |
| Billard, JM; Daniel, H; Pumain, R | 1 |
| Anderson, RJ; Breckon, R; Dillingham, MA; Dixon, BS; Kaehny, MM | 1 |
| Kangrga, I; Larew, JS; Randic, M | 1 |
| Hayashi, T; Iwatsuki, M | 1 |
| Carlsson, A; Carlsson, M | 1 |
| Beckstead, RM; Somers, DL | 2 |
| Dierks, T; Krämer, R; Salentin, A | 1 |
| Larson, AA; Skilling, SR; Smullin, DH | 1 |
| Beitz, AJ | 1 |
| Merighi, A; Polak, JM; Theodosis, DT | 1 |
| Chesler, M; Rice, ME | 1 |
| Ji, I; Ji, TH | 1 |
| Flott, B; Seifert, W | 1 |
| Hicks, TP; Norita, M; Onodera, S; Takeda, K | 1 |
| Hoffman, RD; Kevetter, GA | 1 |
| Meldrum, BS | 1 |
| Hoehn, K; White, TD | 1 |
| McMahon, HT; Nicholls, DG | 1 |
| Fujiwara, M; Fukunaga, R; Kameyama, M; Ninomiya, H; Shimohama, S; Taniguchi, T | 1 |
| Ziskind-Conhaim, L | 1 |
| Blacklow, SC; Hermes, JD; Knowles, JR | 1 |
| Khorana, HG; Marti, T; Subramaniam, S | 1 |
| Compton, RP; Hood, WF; Monahan, JB | 1 |
| Bommarito, M; Johnston, MV; McDonald, JW; Silverstein, FS | 1 |
| Engelhard, M; Hess, B; Kreutz, W; Metz, G; Oesterhelt, D; Siebert, F; Soppa, J | 1 |
| Iguchi, M; Ishikawa, Y; Kataoka, K; Katayama, Y; Katoh, Y; Kodama, M; Kohri, K; Kurita, T; Takada, M; Umekawa, T | 1 |
| Battaglioli, G; Martin, DL | 1 |
| Gunawan, S; Treiman, DM; Walton, NY | 2 |
| Alesiani, M; Carla, V; Cherici, G; Moroni, F; Pellegrini-Giampietro, DE | 2 |
| Cuénod, M; Do, KQ; Vollenweider, FX | 1 |
| Erdö, SL; Wolff, JR | 1 |
| Ford, C; Reilly, PJ; Sierks, MR; Svensson, B | 1 |
| Barbeito, L; Dajas, F; Siciliano, J | 1 |
| Kitareewan, S; Walz, FG | 1 |
| Goderie, SK; Higman, S; Kimelberg, HK; Pang, S; Waniewski, RA | 1 |
| Grüngreiff, K; Meier, M; Reum, T; Schmidt, W; Wolf, G | 1 |
| Beitz, AJ; Clements, JR; Magnusson, KR | 1 |
| Ottersen, OP; Rinvik, E; Walberg, F | 1 |
| Goto, S; Ichikawa, M; Matsuyama, K; Miyazaki, C; Yamamoto, J | 1 |
| Hong, JS; Lum, D; Wallace, B; Yang, YJ | 1 |
| Harrison, PH | 1 |
| Marangos, PJ | 1 |
| Kanazawa, I; Roos, RA | 1 |
| al-Obeidi, F; Hruby, VJ; Sanderson, DG | 1 |
| Korpela, T; Kurkijärvi, K; Vierijoki, T | 1 |
| Dalkara, T; Erdemli, G; Onur, R | 1 |
| Albers, GW | 1 |
| Kikura, R; Ohno, R; Sawai, T; Tsukamoto, K | 1 |
| Drapeau, C; Pellerin, L; Rostworowski, K; Wolfe, LS | 1 |
| Glaum, SR; Miller, RJ; Scholz, WK | 1 |
| Aniksztejn, L; Ben-Ari, Y; Charriaut-Marlangue, C; Roisin, MP | 2 |
| Cox, JA; Felder, CC; Henneberry, RC | 1 |
| Brien, J; Patrick, J; Penning, DH | 1 |
| Attwell, D; Sarantis, M | 1 |
| Markram, H; Segal, M | 1 |
| Butterworth, RF; Cotman, CW; Giguere, JF; Peterson, C | 1 |
| Kantrowitz, ER; Middleton, SA; Tauc, P; Vachette, P | 1 |
| Arnerić, SP; Caspary, DM; Lawhorn Armour, BA; Pippin, J; Raza, A | 1 |
| Clements, JD; Jahr, CE; Lester, RA; Westbrook, GL | 1 |
| Collier, RJ; Douglas, CM | 2 |
| Adams, JA; Benkovic, SJ; Thillet, J | 1 |
| Cuénod, M; Perschak, H | 1 |
| Brancati, A; D'Arcangelo, P | 1 |
| Nekliudov, AD | 1 |
| Heikinheimo, P; Heinonen, J; Lahti, R; Meyer, P; Pitkäranta, T; Pohjanoksa, K; Salminen, T | 1 |
| Bowyer, JF; Weiner, N | 1 |
| Nistri, A; Sivilotti, L; Welsh, DM | 1 |
| Hata, Y; Hicks, TP; Tamura, H; Tsumoto, T; Yamatodani, A | 1 |
| Choi, DW | 1 |
| Miyamoto, T; Okada, Y; Sakurai, T | 1 |
| Bovée, WM; de Graaf, AA | 1 |
| Bowe, MA; Burke, SP; Bustos, GA; Martin, D; Nadler, JV | 1 |
| Bockaert, J; Dumuis, A; Oomagari, K; Pin, JP; Sebben, M | 1 |
| Ciesielski, L; Clement, J; Mandel, P; Simler, S | 1 |
| Becquet, D; Faudon, M; Hery, F | 1 |
| Aksamit, RR; Backlund, PS; Cantoni, GL; Date, T; Fujioka, M; Gomi, T; Takata, Y | 1 |
| Britt, M; Chapdelaine, MJ; Keith, RA; LaMonte, D; Mangano, TJ; Patel, J; Powel, RJ; Pullan, LM; Stumpo, RJ; Warwick, PJ | 1 |
| Brosnan, JT; Brosnan, ME; Dhanakoti, SN; Herzberg, GR | 1 |
| Hestrin, S; Nicoll, RA; Sah, P | 2 |
| Salminen, SO; Streeter, JG | 2 |
| Ohe, Y; Pan-Hou, H; Suda, Y; Sumi, M; Yoshioka, M | 1 |
| Bos, KD; Bruyn, GW; Ferrari, MD; Malessy, MJ; Odink, J | 1 |
| Marchi, M; Paudice, P; Raiteri, M | 1 |
| Dierks, T; Heberger, C; Krämer, R; Salentin, A | 1 |
| Bidlack, JM; Bunzow, J; Civelli, O; Grandy, DK; Hanneman, E; Machida, CA; Shih, M | 1 |
| Herberg, LJ; Rose, IC | 1 |
| Bockaert, J; Didier, M; Heaulme, M; Pin, JP; Soubrié, P | 1 |
| Kapel'ko, VI; Oleĭnikov, OD; Pisarenko, OI; Shul'zhenko, VS; Studneva, IM | 1 |
| Laake, JH; Meldrum, BS; Ottersen, OP; Walberg, F; Zhang, N | 1 |
| Kumashiro, H; Mori, N; Wada, JA | 2 |
| Nicholson, C; Rice, ME | 1 |
| Anderson, KJ; Bridges, RJ; Cotman, CW; Monaghan, DT; Tavoularis, AL | 1 |
| Attwell, D; Nicholls, D | 1 |
| Collier, RJ; Reich, KA; Weinstein, BR; Wilson, BA | 1 |
| Nathans, J | 1 |
| Hiramatsu, M; Janjua, NA; Mori, A | 1 |
| Hanitzsch, R; Mättig, WU | 1 |
| Tsumoto, T | 1 |
| Higashihara, Y; Hiramatsu, M; Mori, A | 1 |
| Boos, R; Müller, F; Wässle, H | 1 |
| Dawson, R; Sherry, DM; Ulshafer, RJ; Wallace, DR | 1 |
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| Bernitzky, CCM; Greetham, GM; Higuchi, Y; Horch, M; Hunt, NT; Ishii, M; Karafoulidi-Retsou, C; Kulka-Peschke, CJ; Lauterbach, L; Lenz, O; Lorent, C; Matsuura, H; Preissler, J; Procacci, B; Rippers, Y; Schulz, AC; Schulz, C; Teutloff, C; Wahlefeld, S; Wiemann, C; Wrathall, SLD; Zebger, I | 1 |
| Ban, M; He, J; Kong, L; Wang, D; Xiao, Q; Yuan, F; Zhu, X | 1 |
| Inoue, A; Kanemura, Y; Kitazawa, R; Kunieda, T; Kusakabe, K; Nakamura, Y; Nishikawa, M; Ohnishi, T; Ohtsuka, Y; Ozaki, S; Shigekawa, S; Suehiro, S; Tanaka, J; Watanabe, H; Yamashita, D; Yano, H | 1 |
| Bao, X; Chen, X; Cui, J; Liu, L; Meng, Z; Wang, J; Yang, C | 1 |
| Chen, L; Gu, J; Huang, C; Kong, Q; Lin, D; Lu, R; Wu, W | 1 |
| DI, LQ; Huang, X; Lu, YY; Luo, ZC; Qi, MY; Shan, JJ; Zhang, W | 1 |
| Chen, X; Jia, W; Jiao, J; Liu, X; Wan, X; Wang, A; Wang, Q; Zhang, L; Zhang, Y; Zhu, L; Zhuang, P | 1 |
| Chen, M; Deng, Z; Li, J; Liu, T; Mao, R; Peng, Q; San, X; Wang, Q; Xiao, W; Xie, H; Zhao, Z | 1 |
| Chen, J; Liu, HS; Liu, SB; Sa, RN; Tan, HZ; Wang, YM; Xie, JJ; Yu, Y; Zhao, F; Zou, Y | 1 |
| Guan, W; Orellana, KG; Spafford, JD; Stephens, RF; Zhorov, BS | 1 |
| Hartmann-Petersen, R; Jacobsen, NL; Kragelund, BB; Lindemose, S; Lindorff-Larsen, K; Lundsgaard, JE; Newcombe, EA; Pesce, F; Prestel, A; Roesgaard, MA; Tranchant, EE | 1 |
| Thormann, W | 1 |
| Balakin, A; Novak, P; Temnik, M | 1 |
| Altynbekov, KS; Asadullin, AR; Gayduk, AJ; Khasanova, AK; Markina, EA; Nasyrova, RF; Petrova, MM; Shipulin, GA; Shnayder, NA | 1 |
| Hu, L; Liu, Y; Lv, F; Ma, L; Pu, J; Shen, Y; Shi, Y; Xie, X; Yang, W; Zhang, H | 1 |
| Akiduki, S; Matsumoto, H; Miura, N; Morishita, K; Yasuda, T | 1 |
| Guo, J; Han, D; Hu, Y; Li, M; Shi, L; Wei, J; Zhang, T | 1 |
| Barker, PB; Cascella, NG; Coughlin, JM; Geman, D; Kelly, A; Nestadt, G; Nucifora, FC; Palaniyappan, L; Sawa, A; Sedlak, TW; Wang, M; Yang, K; Younes, L | 1 |
| Alexandre-Ribeiro, SR; Bernardi, MM; Bondan, EF; Coque, AC; Flório, JC; Garcia-Gomes, MSA; Gonçalves, FB; Kirsten, TB; Lebrun, I; Massironi, SMG; Mori, CMC; Sandini, TM; Silva-Sampaio, AC | 1 |
| Akkaoui, K; Chen, Y; Digby, ZA; Schlenoff, JB | 1 |
| Debert, CT; DeMayo, MM; Harris, AD; MacMaster, FP; McGirr, A; Selby, B | 1 |
| Beauchamp, MH; Bell, TK; Craig, W; Doan, Q; Harris, AD; Joyce, JM; La, PL; Mauthner, M; Yeates, KO; Zemek, R | 1 |
| Ching, J; Ho, CSH; Tay, GWN; Wee, HN | 1 |
| Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY | 1 |
| Bagshawe, M; Bell, TK; Boudes, E; DeMayo, MM; Harris, AD; Lebel, C; Perdue, MV | 1 |
| Chen, L; Cheng, Y; Du, Y; Li, YB; Wang, YL; Xv, CX; Yan, MC; Zhong, XL | 1 |
| Chai, Y; Che, YX; Hu, JP; Ji, D; Lin, Q; Liu, T; Qu, WJ; Shi, B; Wei, TB; Yao, H | 1 |
| Holeček, M | 1 |
| Adnan, M; Alouffi, S; Alreshidi, F; Alreshidi, M; Badraoui, R; Bardakci, F; Dunstan, H; Hossain, A; Roberts, T; Saeed, M; Snoussi, M | 1 |
| Pavlova, I; Ruda-Kucerova, J | 1 |
| Ahel, I; Filippov, DV; Liszczak, G; Mohapatra, J; Rack, JGM; Tashiro, K; Wijngaarden, S | 1 |
| Bassi, MS; Bellingacci, L; Bruno, A; Buttari, F; Centonze, D; Di Filippo, M; Di Maio, A; Dolcetti, E; Errico, F; Finardi, A; Furlan, R; Galifi, G; Gilio, L; Mancini, A; Nuzzo, T; Usiello, A | 1 |
| Bezwada, D; Brooks, B; Cai, F; Cai, L; Chang, MC; DeBerardinis, RJ; Do, D; Gu, W; Jin, ES; Kelekar, S; Ko, B; Mahar, R; Malloy, CR; Margulis, V; Martin-Sandoval, M; Mathews, TP; Merritt, ME; Oaxaca, KC; Pachnis, P; Vu, HS; Wu, Z; Yang, C; Zacharias, LG | 1 |
| Chen, J; Guo, D; He, J; Jia, Y; Peng, H; Shi, M; Sun, L; Wang, A; Wang, Y; Xu, Q; Xu, T; Yang, P; Zhang, Y; Zhong, C; Zhu, Z | 1 |
| Bui, TH; Cole, CC; Hartgerink, JD; Misiura, M; Williams, J; Yu, LT | 1 |
148 review(s) available for aspartic acid and glutamic acid
| Article | Year |
|---|---|
[Search for the substances selectively acting on the mediatory transmission of stimulatory amino acids].
Topics: Amino Acids, Diamino; Aspartic Acid; Brain; Drug Evaluation; Glutamates; Glutamic Acid; Neurotransmitter Agents; Propionates; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical; Synaptic Transmission | 1992 |
Amino acid composition of dentine in permanent human teeth.
Topics: Amino Acids; Asparagine; Aspartic Acid; Dentin; Glutamates; Glutamic Acid; Humans; Hydroxylysine; Lysine | 1992 |
Heterogeneity of high affinity uptake of L-glutamate and L-aspartate in the mammalian central nervous system.
Topics: Animals; Aspartic Acid; Biological Transport; Brain; Glutamates; Glutamic Acid; Mammals | 1992 |
Nitrogen metabolism: neuronal-astroglial relationships.
Topics: Alanine; Animals; Aspartic Acid; Astrocytes; Cell Communication; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glutamine; Glutathione; Nerve Tissue Proteins; Neurons; Nitrogen; Synaptosomes; Veratridine | 1992 |
Calcium-independent release of amino acid neurotransmitters: fact or artifact?
Topics: Animals; Aspartic Acid; Brain; Calcium; Carrier Proteins; Cations; Cell Compartmentation; Chelating Agents; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Intracellular Fluid; Ion Channel Gating; Ion Channels; Ionophores; Magnesium; Membrane Potentials; Neuroglia; Neurotransmitter Agents; Rats; Secretory Rate; Tetrodotoxin | 1992 |
Mechanisms that may underlie the behavioural effects of ethanol.
Topics: Alcoholic Intoxication; Animals; Aspartic Acid; Behavior; Behavior, Animal; Calcium; Calcium Channels; Cell Membrane; Dihydropyridines; Drug Tolerance; Ethanol; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Ion Channel Gating; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Synaptic Transmission | 1991 |
Nonenzymatic deamidation of asparaginyl and glutaminyl residues in proteins.
Topics: Amides; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Glutamates; Glutamic Acid; Glutamine; Humans; Molecular Sequence Data; Protein Processing, Post-Translational | 1991 |
Quinolinic acid and kynurenic acid in the mammalian brain.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Transport; Brain Chemistry; Brain Diseases; Dioxygenases; Epilepsy, Temporal Lobe; Glutamates; Glutamic Acid; Humans; Kynurenic Acid; Kynurenine; Lyases; Nerve Degeneration; Oxygenases; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Neurotransmitter; Transaminases | 1991 |
Rational basis for the development of new antiepileptic drugs.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Electroencephalography; Epilepsy; Glutamates; Glutamic Acid; Humans; Synaptic Transmission | 1991 |
Excitatory amino acids in epilepsy and novel anti-epileptic drugs.
Topics: Animals; Anticonvulsants; Aspartic Acid; Epilepsy; Glutamates; Glutamic Acid; Humans; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1991 |
Introduction to the excitatory amino acid system.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Humans; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Interactions between glutamatergic and monoaminergic systems within the basal ganglia--implications for schizophrenia and Parkinson's disease.
Topics: Animals; Anticonvulsants; Aspartic Acid; Basal Ganglia; Biogenic Amines; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Humans; N-Methylaspartate; Parkinson Disease; Schizophrenia | 1990 |
Excitatory amino acid transmitters in epilepsy.
Topics: Anticonvulsants; Aspartic Acid; Epilepsy; Epilepsy, Temporal Lobe; Glutamates; Glutamic Acid; Humans; Ion Channels; Lamotrigine; Neurotransmitter Agents; Triazines | 1991 |
Ultrastructural description of glutamate-, aspartate-, taurine-, and glycine-like immunoreactive terminals from five rat brain regions.
Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Glutamates; Glutamic Acid; Glycine; Immunohistochemistry; Male; Rats; Rats, Inbred Strains; Synapses; Taurine | 1990 |
Potential therapeutic uses of N-methyl-D-aspartate antagonists in cerebral ischemia.
Topics: Aspartic Acid; Brain Ischemia; Glutamates; Glutamic Acid; Humans; Models, Biological; N-Methylaspartate; Nervous System; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Formation of 12-lipoxygenase metabolites in rat cerebral cortical slices: stimulation by calcium ionophore, glutamate and N-methyl-D-aspartate.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonate 12-Lipoxygenase; Arachidonate Lipoxygenases; Aspartic Acid; Calcimycin; Cerebral Cortex; Glutamates; Glutamic Acid; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Agents; Phorbol Esters | 1990 |
[Aliphatic alpha-amino acids as biologically active compounds].
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cysteine; Glutamates; Glutamic Acid; Glycine; Homeostasis; Humans | 1990 |
Cerebral hypoxia: some new approaches and unanswered questions.
Topics: Animals; Aspartic Acid; Brain Diseases; Cell Survival; Cerebrovascular Circulation; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Hypoxia; N-Methylaspartate; Neuroglia; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Presynaptic muscarinic receptors in the central nervous system.
Topics: Animals; Aspartic Acid; Brain; Central Nervous System; Dopamine; Glutamates; Glutamic Acid; Homeostasis; Humans; Receptors, Muscarinic; Receptors, Neurotransmitter | 1990 |
The release and uptake of excitatory amino acids.
Topics: Animals; Aspartic Acid; Biological Transport; Calcium; Exocytosis; Glutamates; Glutamic Acid; Humans; Hypoxia; Neurotransmitter Agents | 1990 |
Excitatory amino acid transmitters and their receptors in neural circuits of the cerebral neocortex.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; Humans; Neurons; Neurotransmitter Agents; Receptors, Amino Acid; Receptors, Cell Surface | 1990 |
Quinoxalinediones as excitatory amino acid antagonists in the vertebrate central nervous system.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Binding, Competitive; Central Nervous System; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Membrane Potentials; N-Methylaspartate; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Signal Transduction; Spinal Cord; Structure-Activity Relationship; Vertebrates | 1990 |
Excitotoxin-mediated neuron death in youth and old age.
Topics: Aging; Alzheimer Disease; Amino Acids; Animals; Aspartic Acid; Brain Diseases, Metabolic; Brain Injuries; Calcium Channels; Cell Survival; Central Nervous System; Central Nervous System Diseases; Food; Food Additives; Glutamates; Glutamic Acid; Humans; Ion Channel Gating; Neurons; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate | 1990 |
Excitatory amino acid neurotransmission: NMDA receptors and Hebb-type synaptic plasticity.
Topics: Amino Acids; Animals; Aspartic Acid; Central Nervous System; Glutamates; Glutamic Acid; Glycine; Humans; Ion Channels; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission | 1988 |
Release of glutamate, aspartate, and gamma-aminobutyric acid from isolated nerve terminals.
Topics: Animals; Aspartic Acid; Calcium; Cell Membrane; Cytoplasm; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Nerve Endings; Organelles; Synaptosomes | 1989 |
N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia?
Topics: Aspartic Acid; Brain; Brain Ischemia; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Models, Neurological; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1989 |
Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Basal Ganglia Diseases; Brain; Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Huntington Disease; Mice; Movement Disorders; Nerve Degeneration; Neurotransmitter Agents; Parkinson Disease; Rats | 1985 |
Excitatory amino acid transmitters in neuronal circuits of the cat visual cortex.
Topics: Acetylcholine; Animals; Aspartic Acid; Cats; Dipeptides; Evoked Potentials, Visual; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Neurons; Neurotransmitter Agents; Pipecolic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Visual Cortex | 1986 |
Neurochemical correlates to selective neuronal vulnerability.
Topics: Adenosine; Afferent Pathways; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Calcium; Chlorides; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hypoglycemia; Models, Biological; Neural Inhibition; Neurochemistry; Neurons; Neurotransmitter Agents; Norepinephrine; Parasympathomimetics; Quinolinic Acid; Quinolinic Acids; Rats | 1985 |
Evaluation of the immunocytochemical method for amino acids.
Topics: Amino Acids; Animals; Antigen-Antibody Reactions; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Histocytochemistry; Immunochemistry; Rats; Tissue Distribution | 1986 |
Mitochondrial transmembrane proton electrochemical potential, di- and tricarboxylate distribution and the poise of the malate-aspartate cycle in the intact myocardium.
Topics: Animals; Aspartic Acid; Carboxylic Acids; Cell Compartmentation; Citric Acid Cycle; Electrochemistry; Energy Metabolism; Glutamates; Glutamic Acid; Malates; Mathematics; Mitochondria, Heart; Protons | 1986 |
Amino acid profiles in cortex of conscious rat: recent studies and future perspectives.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Functional Laterality; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Perfusion; Rats; Tissue Distribution | 1986 |
The physiology of excitatory amino acids in the vertebrate central nervous system.
Topics: Amino Acids; Animals; Aspartic Acid; Central Nervous System; Glutamates; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Vertebrates | 1987 |
Endogenous excitotoxic agents.
Topics: Animals; Aspartic Acid; Cell Survival; Central Nervous System; Dementia; Epilepsy; Glutamates; Glutamic Acid; Humans; Huntington Disease; Models, Neurological; Neurons; Quinolinic Acid; Quinolinic Acids | 1987 |
Tracing of neurons with glutamate or gamma-aminobutyrate as putative transmitters.
Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Glycine; Histocytochemistry; Humans; Neurons; Neurotransmitter Agents | 1987 |
Excitatory receptors and their role in excitotoxicity.
Topics: Aminobutyrates; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Humans; N-Methylaspartate; Neurons; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
On the excitatory post-synaptic potential evoked by stimulation of the optic tract in the rat lateral geniculate nucleus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aminobutyrates; Animals; Aspartic Acid; Calcium; Dipeptides; Glutamates; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Optic Nerve; Rats; Rats, Inbred Strains; Synapses; Thalamic Nuclei; Valine | 1987 |
The transmitter role of glutamate in nervous systems.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Invertebrates; Nervous System Physiological Phenomena; Neuromuscular Junction; Neurotransmitter Agents; Receptors, Neurotransmitter; Vertebrates | 1987 |
First events in vision: the generation of responses in vertebrate rods.
Topics: Animals; Aspartic Acid; Calcium; Glutamates; Glutamic Acid; Ion Channels; Light; Membrane Potentials; Photoreceptor Cells; Rod Cell Outer Segment; Sodium; Synapses; Vertebrates; Vision, Ocular | 1981 |
Membrane cholesterol, tumorigenesis, and the biochemical phenotype of neoplasia.
Topics: Acetates; Animals; Asparagine; Aspartic Acid; Biological Transport, Active; Cell Division; Cell Membrane Permeability; Cholesterol; Citric Acid Cycle; Electron Spin Resonance Spectroscopy; Glucose; Glutamates; Glutamic Acid; Glutamine; Lipid Bilayers; Liver Neoplasms, Experimental; Membrane Lipids; Mitochondria; Mitochondria, Liver; Models, Biological; Neoplasms; Oxygen Consumption; Phenotype; Purines; Pyrimidines; Pyruvates; Pyruvic Acid; Surface Properties | 1981 |
On the evolution of neurochemical transmission.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Aspartic Acid; Behavior; Biological Evolution; Cell Communication; Chemoreceptor Cells; Dopamine; Enkephalins; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Humans; Memory; Models, Biological; Models, Neurological; Neurochemistry; Neurotransmitter Agents; Norepinephrine; Serotonin; Structure-Activity Relationship | 1981 |
The stimulation of ion fluxes in brain slices by glutamate and other excitatory amino acids.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Brain; Calcium; Cations; Cell Membrane Permeability; Glutamates; Glutamic Acid; In Vitro Techniques; Ion Channels; Kainic Acid; Kinetics; N-Methylaspartate; Potassium; Rubidium; Sodium; Sodium-Potassium-Exchanging ATPase | 1981 |
Glutamate: a neurotransmitter in mammalian brain.
Topics: Animals; Aspartic Acid; Brain; Calcium; Chlorides; Glutamates; Glutamic Acid; Humans; Kinetics; Neurons; Neurotransmitter Agents; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Sodium; Subcellular Fractions; Synapses | 1984 |
Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors.
Topics: Amino Acids; Animals; Aspartic Acid; Binding Sites; Brain; Brain Chemistry; Cats; Electrophysiology; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Ligands; Mice; Neurotransmitter Agents; Oxidation-Reduction; Radioligand Assay; Rats; Receptors, Neurotransmitter; Synaptic Transmission | 1984 |
Glutamate metabolism in the retina: a larger perspective.
Topics: Animals; Aspartic Acid; Brain; Cells, Cultured; Chick Embryo; Enzyme Induction; gamma-Aminobutyric Acid; gamma-Glutamyltransferase; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Humans; Hydrocortisone; Neurotransmitter Agents; Rats; Retina; Species Specificity | 1984 |
Abnormal metabolism of neuroexcitatory amino acids in olivopontocerebellar atrophy.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellar Ataxia; Fibroblasts; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Humans; Malates; Olivary Nucleus; Phenotype; Pons; Rats; Skin; Syndrome | 1984 |
The toxic effects of glutamate and related compounds in the retina and the brain.
Topics: Animals; Aspartic Acid; Blood-Brain Barrier; Blood-Retinal Barrier; Brain; Glutamates; Glutamic Acid; Neurotransmitter Agents; Retina | 1982 |
Roles of excitatory amino acids in expression of secondarily generalized limbic seizures: observations in the kindling model of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dimethyl Sulfoxide; Electric Stimulation; Glutamates; Glutamic Acid; Humans; Kindling, Neurologic; Seizures | 1993 |
Neurochemical and biophysical assessment of neonatal hypoxic-ischemic encephalopathy.
Topics: Animals; Aspartic Acid; Asphyxia Neonatorum; Brain; Brain Diseases; Brain Ischemia; Electrophysiology; Glutamates; Glutamic Acid; Humans; Infant, Newborn; Norepinephrine; Purines | 1994 |
Diverse distribution and function of fibrous microtubule-associated proteins in the nervous system.
Topics: Animals; Aspartic Acid; Axons; Dendrites; Gene Expression Regulation; Glutamates; Glutamic Acid; Humans; Microtubule-Associated Proteins; Microtubules; Nerve Growth Factors; Nerve Tissue Proteins; Nervous System; Neuronal Plasticity; Sensation | 1994 |
Pest sequences in nuclear proteins.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Nuclear Proteins; Proline; Serine; Threonine | 1993 |
The melibiose permease of Escherichia coli: importance of the NH2-terminal domains for cation recognition by the Na+/sugar cotransporter.
Topics: Aspartic Acid; Cations, Monovalent; Escherichia coli; Glutamates; Glutamic Acid; Melibiose; Membrane Transport Proteins; Monosaccharide Transport Proteins; Mutation; Protein Conformation; Symporters | 1993 |
Gene expression and chemical diversity in hypothalamic neurosecretory neurons.
Topics: Animals; Aspartic Acid; Gene Expression Regulation; Glutamates; Glutamic Acid; Humans; Hypophysectomy; Hypothalamic Hormones; Hypothalamo-Hypophyseal System; Hypothalamus; Neurons; Neuropeptides; Neurotransmitter Agents; Osmolar Concentration; Rats; Rats, Brattleboro; Sodium Glutamate | 1993 |
[Effect of excitatory amino acids, Ca2+ on delayed neuronal death in hippocampus following transient forebrain ischemia].
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Calcium-Transporting ATPases; Glutamates; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Necrosis; Neurons | 1993 |
Mutagenesis studies of the cardiac Na(+)-Ca2+ exchanger.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Calcium; Carrier Proteins; Dogs; Glutamic Acid; Glycine; Molecular Sequence Data; Mutagenesis, Site-Directed; Myocardium; Serine; Sodium; Sodium-Calcium Exchanger; Structure-Activity Relationship; Threonine | 1996 |
Transport mutants and transport genes of Corynebacterium glutamicum.
Topics: Amino Acid Sequence; Amino Acids; Aspartic Acid; Base Sequence; Corynebacterium; Genes, Bacterial; Genetic Vectors; Glucose; Glutamic Acid; Lysine; Models, Biological; Molecular Sequence Data; Multigene Family; Mutation; Plasmids; Restriction Mapping | 1996 |
Amino acid neurotransmission: dynamics of vesicular uptake.
Topics: Amino Acids; Animals; Aspartic Acid; beta-Alanine; Biological Transport; Central Nervous System; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Membrane Potentials; Neurotransmitter Agents; Proline; Synaptic Vesicles; Taurine | 1996 |
On the release of glutamate and aspartate in the basal ganglia of the rat: interactions with monoamines and neuropeptides.
Topics: Animals; Aspartic Acid; Basal Ganglia; Biogenic Monoamines; Glutamic Acid; Neuropeptides; Rats | 1997 |
The biological basis of schizophrenia: new directions.
Topics: Animals; Aspartic Acid; Brain; Cholecystokinin; Disease Models, Animal; Dopamine; Entorhinal Cortex; gamma-Aminobutyric Acid; Genetic Linkage; Genetic Markers; Glutamic Acid; Humans; RNA, Messenger; Rodentia; Schizophrenia | 1997 |
Use of fluorocitrate and fluoroacetate in the study of brain metabolism.
Topics: Animals; Aspartic Acid; Brain; Carbon Radioisotopes; Citrates; Citric Acid Cycle; Fluoroacetates; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Neuroglia | 1997 |
Mediator substances of the pineal neuronal network of mammals.
Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Microscopy, Immunoelectron; Nerve Net; Neurons; Pineal Gland | 1997 |
Is all bone the same? Distinctive distributions and properties of non-collagenous matrix proteins in lamellar vs. woven bone imply the existence of different underlying osteogenic mechanisms.
Topics: 1-Carboxyglutamic Acid; Aspartic Acid; Biomechanical Phenomena; Bone and Bones; Bone Diseases; Bone Matrix; Bone Resorption; Chromosome Mapping; Endoplasmic Reticulum; Extracellular Matrix Proteins; Glutamic Acid; Glycoproteins; Humans; Integrin-Binding Sialoprotein; Osteocalcin; Osteoclasts; Osteogenesis; Parathyroid Hormone; Phosphoproteins; Proteins; Sarcoplasmic Reticulum; Serine; Sialoglycoproteins; Time Factors; Tooth | 1998 |
[Glutamylendopeptidases from microorganisms--a new subfamily of chymotrypsin proteinases].
Topics: Amino Acid Sequence; Aspartic Acid; Bacteria; Glutamic Acid; Hydrolysis; Molecular Sequence Data; Peptides; Proteins; Sequence Homology, Amino Acid; Serine Endopeptidases; Substrate Specificity | 1998 |
Potential cardiovascular applications of glutamate, aspartate, and other amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Cardioplegic Solutions; Clinical Trials as Topic; Glutamic Acid; Humans; In Vitro Techniques; Myocardial Ischemia; Myocardium; Oxygen Consumption | 1998 |
Detrimental effects of chronic hypothalamic-pituitary-adrenal axis activation. From obesity to memory deficits.
Topics: Acquired Immunodeficiency Syndrome; Adrenocorticotropic Hormone; Amygdala; Animals; Arginine Vasopressin; Aspartic Acid; Chronic Disease; Cognition Disorders; Corticotropin-Releasing Hormone; Feedback; Glucocorticoids; Glutamic Acid; Hippocampus; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Memory Disorders; Mice; Models, Biological; Obesity; Pituitary-Adrenal System; Rats; Stress, Physiological; Synaptic Transmission | 1998 |
Release of endogenous excitatory amino acids in the neostriatum of the rat under physiological and pharmacologically-induced conditions.
Topics: Animals; Aspartic Acid; Glutamic Acid; Neostriatum; Neurons; Rats | 1998 |
1H MR spectroscopy in patients with mesial temporal epilepsy.
Topics: Aspartic Acid; Choline; Creatine; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Humans; Magnetic Resonance Imaging | 1998 |
A pharmacological review of competitive inhibitors and substrates of high-affinity, sodium-dependent glutamate transport in the central nervous system.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Binding, Competitive; Biological Transport; Central Nervous System; Glutamic Acid; Humans; Neurotransmitter Agents; Sodium | 1999 |
Molecular properties of inositol 1,4,5-trisphosphate receptors.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Calcium; Calcium Channels; Glutamic Acid; Inositol 1,4,5-Trisphosphate Receptors; Models, Biological; Phosphorylation; Receptors, Cytoplasmic and Nuclear | 1999 |
Neurochemical brain imaging investigations of schizophrenia.
Topics: Aspartic Acid; Brain; Corpus Striatum; Dopamine; Glutamic Acid; Homovanillic Acid; Humans; Magnetic Resonance Imaging; Receptors, Dopamine D2; Receptors, GABA; Schizophrenia; Serotonin; Synaptic Transmission; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 1999 |
Expression patterns and regulation of glutamate transporters in the developing and adult nervous system.
Topics: Animals; Aspartic Acid; Biological Transport; Central Nervous System; Gene Expression; Glutamic Acid; Humans | 1999 |
Neuroactive amino acids in focally epileptic human brain: a review.
Topics: Aspartic Acid; Brain; Epilepsies, Partial; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Magnetic Resonance Spectroscopy; Neurotransmitter Agents | 1999 |
Alpha/beta hydrolase fold enzymes: the family keeps growing.
Topics: Aspartic Acid; Binding Sites; Glutamic Acid; Hydrolases; Models, Molecular; Protein Conformation; Protein Folding | 1999 |
Proton magnetic resonance spectroscopy of the human brain in schizophrenia.
Topics: Aspartic Acid; Brain; Choline; Creatine; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Protons; Schizophrenia | 2000 |
Alterations in neurochemistry during retinal degeneration.
Topics: Animals; Animals, Newborn; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Humans; Immunohistochemistry; Neurotransmitter Agents; Photoreceptor Cells, Vertebrate; Rats; Retina; Retinal Degeneration; Retinitis Pigmentosa; Time Factors | 2000 |
Five-membered ring formation in unimolecular reactions of peptides: a key structural element controlling low-energy collision-induced dissociation of peptides.
Topics: Amino Acid Sequence; Aspartic Acid; Chemical Phenomena; Chemistry, Physical; Cyclization; Glutamic Acid; Mass Spectrometry; Molecular Structure; Peptide Fragments; Peptides | 2000 |
Synthetic analogs of zinc enzymes.
Topics: Alcohol Dehydrogenase; Amidohydrolases; Amino Acid Motifs; Aminopeptidases; Animals; Aspartic Acid; Bacterial Proteins; Bicarbonates; Binding Sites; Carbonic Anhydrases; Carboxypeptidases; Catalysis; Cations, Divalent; Cysteine; Dihydroorotase; DNA Repair; Enzymes; Escherichia coli Proteins; Glutamic Acid; Histidine; Ligands; Liver; Matrix Metalloproteinases; Metalloproteins; Models, Chemical; Molecular Structure; N-Acetylmuramoyl-L-alanine Amidase; Nitrates; O(6)-Methylguanine-DNA Methyltransferase; Porphobilinogen Synthase; Spectrum Analysis; Thermolysin; Transcription Factors; Water; Zinc | 2001 |
Structure-function relationships of Na(+), K(+), ATP, or Mg(2+) binding and energy transduction in Na,K-ATPase.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Cations; Cell Membrane; Energy Transfer; Glutamic Acid; Humans; Ligands; Magnesium; Mutagenesis, Site-Directed; Potassium; Protein Conformation; Recombinant Proteins; Rubidium; Sodium; Sodium-Potassium-Exchanging ATPase; Structure-Activity Relationship; Tellurium | 2001 |
Metabolite and light regulation of metabolism in plants: lessons from the study of a single biochemical pathway.
Topics: Amino Acids, Dicarboxylic; Arabidopsis; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Carbon; Gene Expression Regulation, Plant; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Light; Nitrogen; Receptors, Glutamate | 2001 |
Aspartate and glutamate transport in acutely and chronically ethanol exposed neonatal rat primary astrocyte cultures.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; Central Nervous System Depressants; Ethanol; Glutamic Acid; Humans; Rats; Time Factors | 2001 |
Neurotransmission in the vestibular endorgans--glutamatergic transmission in the afferent synapses of hair cells.
Topics: Animals; Aspartic Acid; Glutamic Acid; Glutaminase; Glutamine; Hair Cells, Auditory, Inner; Neurons, Afferent; Receptors, Glutamate; Synaptic Transmission | 2001 |
Roles of inhibition for transforming binaural properties in the brainstem auditory system.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Auditory Pathways; Bicuculline; Brain Stem; Chiroptera; Evoked Potentials, Auditory, Brain Stem; gamma-Aminobutyric Acid; Glutamic Acid; Inferior Colliculi; Models, Neurological; Neurons; Olivary Nucleus; Strychnine | 2002 |
Excitatory amino acid neurotoxicity.
Topics: Animals; Aspartic Acid; Brain; Brain Injuries; Brain Ischemia; Calcium; Epilepsy; Glutamic Acid; Humans; Mitochondria; Nervous System Diseases; Neurodegenerative Diseases; Reactive Nitrogen Species; Reactive Oxygen Species; Receptors, Glutamate; Signal Transduction | 2002 |
[Excitatory amino acid transporters: development of regulatory molecules for their functional analysis].
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Drug Design; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Receptors, Glutamate | 2003 |
Amino acids as regulators and components of nonproteinogenic pathways.
Topics: Amino Acids; Animals; Aspartic Acid; Cell Size; Glutamic Acid; Humans; Insulin; Islets of Langerhans; Metabolism; NAD; Oxidation-Reduction; Signal Transduction; Urea | 2003 |
Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality.
Topics: Animals; Antipsychotic Agents; Aspartic Acid; Glutamic Acid; Glycine; Humans; Nerve Degeneration; Neurotoxins; Psychotic Disorders; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission | 2003 |
Aspartate and glutamate mimetic structures in biologically active compounds.
Topics: Amino Acid Isomerases; Aspartic Acid; Carboxylic Acids; Drug Design; Enzyme Inhibitors; Glutamic Acid; Molecular Mimicry; Molecular Structure; Oligopeptides | 2004 |
1H-MRS evaluation of metabolism in Alzheimer's disease and vascular dementia.
Topics: Acetylcholine; Alzheimer Disease; Aspartic Acid; Cerebral Cortex; Dementia, Vascular; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Neurons | 2004 |
Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism.
Topics: Alanine; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Lipid Metabolism; Magnetic Resonance Spectroscopy; Phosphocreatine | 2004 |
Excitatory neurotoxins as food additives: an evaluation of risk.
Topics: Adult; Age Factors; Aspartame; Aspartic Acid; Blood-Brain Barrier; Child; Cysteine; Dietary Supplements; Electrophysiology; Excitatory Amino Acids; Female; Food Analysis; Glutamic Acid; Humans; Neurotoxicity Syndromes; Neurotoxins; Pregnancy; Protein Hydrolysates; Risk Assessment; Risk Factors; Species Specificity | 1981 |
The protective effect of adenosine A2A receptor antagonism in cerebral ischemia.
Topics: Adenosine A2 Receptor Antagonists; Animals; Aspartic Acid; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Hypoxia, Brain; Neuroprotective Agents; Receptor, Adenosine A2A; Time Factors | 2005 |
The control of adenohypophysial hormone secretion by amino acids and peptides in swine.
Topics: Amino Acids; Animals; Aspartic Acid; Galanin; Ghrelin; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Neuropeptide Y; Neuropeptides; Opioid Peptides; Orexins; Peptide Hormones; Peptides; Pituitary Hormones, Anterior; Substance P; Swine | 2005 |
Association of the endothelial nitric oxide synthase (NOS3) Glu298Asp gene polymorphism with the risk of Alzheimer's disease-- a meta-analysis.
Topics: Alleles; Alzheimer Disease; Asian People; Aspartic Acid; Case-Control Studies; Confidence Intervals; Gene Frequency; Genotype; Glutamic Acid; Homozygote; Humans; Models, Statistical; Nitric Oxide Synthase Type III; Odds Ratio; Polymorphism, Genetic; Risk Factors; White People | 2005 |
Central N-acetyl aspartylglutamate deficit: a possible pathogenesis of schizophrenia.
Topics: Animals; Aspartic Acid; Brain; Dipeptides; Glutamic Acid; Humans; Models, Neurological; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2005 |
Glutamate-based therapeutic approaches: targeting the glutamate transport system.
Topics: Animals; Aspartic Acid; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Heptanes; Heterocyclic Compounds, 3-Ring; Humans; Prosencephalon | 2006 |
What have we learned from proton magnetic resonance spectroscopy about schizophrenia? A critical update.
Topics: Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Cross-Over Studies; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; N-Methylaspartate; Neurons; Protons; Schizophrenia; Temporal Lobe | 2006 |
Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Brain Chemistry; Child; Choline; Creatine; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy | 2006 |
Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy.
Topics: Analgesics; Animals; Aspartic Acid; Dipeptides; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Molecular Structure; Neurons; Neuroprotective Agents; Organophosphorus Compounds | 2006 |
Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis.
Topics: Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Phosphocreatine; Protons | 2006 |
Canavan disease: a white matter disorder.
Topics: Aspartic Acid; Biomarkers; Brain; Canavan Disease; Diagnosis, Differential; Genetic Counseling; Glutamic Acid; Homeostasis; Humans; Infant; Magnetic Resonance Imaging; Myelin Sheath; Neuroglia; Neurons; Oligodendroglia | 2006 |
Amino acid catabolic pathways of lactic acid bacteria.
Topics: Alanine; Amino Acids; Amino Acids, Aromatic; Amino Acids, Branched-Chain; Asparagine; Aspartate Ammonia-Lyase; Aspartic Acid; Biodegradation, Environmental; Fermentation; Food Microbiology; Glutamate Decarboxylase; Glutamic Acid; Glutamine; Histidine; Lactic Acid; Lactobacillus; Proline | 2006 |
Ligands targeting the excitatory amino acid transporters (EAATs).
Topics: Aspartic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glutamic Acid | 2006 |
VRACs CARVe a path for novel mechanisms of communication in the CNS.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Astrocytes; Brain; Brain Chemistry; Calcium; Cell Size; Central Nervous System; Chelating Agents; Chloride Channels; Chlorides; Furosemide; Glutamic Acid; Humans; Ion Channels; Neurons; Neurotransmitter Agents; Nitrobenzoates; Osmolar Concentration; Protein Kinase Inhibitors; Pyramidal Cells; Synaptic Transmission | 2006 |
Mechanistic differences among retaining disaccharide phosphorylases: insights from kinetic analysis of active site mutants of sucrose phosphorylase and alpha,alpha-trehalose phosphorylase.
Topics: Agaricales; Amino Acid Sequence; Aspartic Acid; Binding Sites; Fructose; Glucosyltransferases; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Leuconostoc; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Phosphates; Vanadates | 2008 |
(1)H MR spectroscopy in pediatrics.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Diseases; Child; Child, Preschool; Choline; Creatine; Glutamic Acid; Glutamine; Humans; Infant; Infant, Newborn; Inositol; Magnetic Resonance Spectroscopy; Phosphocreatine | 2008 |
Co-localization of excitatory and inhibitory transmitters in the brain.
Topics: Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Mossy Fibers, Hippocampal; Synapses | 2008 |
Biologic basis of bipolar disorder in children and adolescents.
Topics: Adolescent; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Brain; Brain-Derived Neurotrophic Factor; Child; Energy Metabolism; Genetic Predisposition to Disease; Glutamic Acid; Glutamine; Humans; Lithium Compounds; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neuropsychological Tests | 2008 |
Central mechanisms in the maintenance of chronic widespread noninflammatory muscle pain.
Topics: Amides; Anesthetics, Local; Aspartic Acid; Chronic Disease; Cyclic AMP; Fatigue; Fibromyalgia; Glutamic Acid; Humans; Myofascial Pain Syndromes; Nerve Block; Nociceptors; Ropivacaine; Signal Transduction; Synaptic Transmission | 2008 |
Applications for magnetic resonance imaging in bipolar disorder.
Topics: Antipsychotic Agents; Aspartic Acid; Bipolar Disorder; Brain; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy | 2007 |
Human fetal brain chemistry as detected by proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Fetus; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Magnetic Resonance Spectroscopy; Protons; Pyruvic Acid | 2009 |
Sweet, bitter and umami receptors: a complex relationship.
Topics: Animals; Aspartic Acid; Catalytic Domain; Dimerization; Food Preferences; Glutamic Acid; Humans; Mice; Models, Biological; Neurons, Afferent; Protein Conformation; Signal Transduction; Taste; Taste Buds; Taste Threshold | 2009 |
Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction.
Topics: Alcoholism; Animals; Appetite Stimulants; Aspartic Acid; Brain; Choline; Cocaine; Creatine; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Marijuana Abuse; Neurochemistry; Opiate Alkaloids; Smoking; Substance-Related Disorders; Toluene | 2010 |
Focus on phosphoaspartate and phosphoglutamate.
Topics: Animals; Aspartic Acid; Bacteria; Eukaryota; Glutamic Acid; Humans; Phosphoproteins; Phosphorylation; Signal Transduction | 2011 |
Possible involvement of glutamatergic signaling machineries in pathophysiology of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Aspartic Acid; Disease Models, Animal; Fibroblasts; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Receptors, Glutamate; Synovial Fluid; Synovial Membrane; Vesicular Glutamate Transport Proteins | 2011 |
Brain structure and function in borderline personality disorder.
Topics: Amygdala; Aspartic Acid; Borderline Personality Disorder; Creatine; Female; Glutamic Acid; Gyrus Cinguli; Hippocampus; Humans; Male; Neuroimaging; Prefrontal Cortex | 2012 |
MR spectroscopic studies of the brain in psychiatric disorders.
Topics: Aspartic Acid; Brain; Creatine; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Mental Disorders | 2012 |
Age-related change in brain metabolite abnormalities in autism: a meta-analysis of proton magnetic resonance spectroscopy studies.
Topics: Adolescent; Age Factors; Aspartic Acid; Asperger Syndrome; Brain; Brain Mapping; Cell Division; Cephalometry; Child; Child Development Disorders, Pervasive; Child, Preschool; Choline; Creatine; Energy Metabolism; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Neuroglia; Reference Values; Young Adult | 2012 |
Proton magnetic resonance spectroscopy as a probe into the pathophysiology of autism spectrum disorders (ASD): a review.
Topics: Aspartic Acid; Brain; Child Development Disorders, Pervasive; Choline; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy | 2013 |
Channelrhodopsin unchained: structure and mechanism of a light-gated cation channel.
Topics: Aspartic Acid; Chlamydomonas reinhardtii; Glutamic Acid; Hydrogen-Ion Concentration; Ion Channel Gating; Ion Transport; Kinetics; Light; Models, Molecular; Protein Conformation; Protons; Retinaldehyde; Rhodopsin; Thermodynamics; Time Factors | 2014 |
Magnetic resonance of the brain in chronic and acute liver failure.
Topics: Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Brain Edema; Choline; Creatine; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Lactic Acid; Liver Failure; Liver Failure, Acute; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neuroimaging | 2014 |
Plastidic aspartate aminotransferases and the biosynthesis of essential amino acids in plants.
Topics: Amino Acids, Essential; Aspartate Aminotransferases; Aspartic Acid; Chloroplasts; Glutamic Acid; Ketoglutaric Acids; Models, Biological; Oxaloacetic Acid; Phylogeny; Plant Proteins; Plants; Plastids; Substrate Specificity; Tyrosine | 2014 |
Association of APE1 Gene Asp148Glu Variant with Digestive Cancer: A Meta-Analysis.
Topics: Aspartic Acid; Digestive System Neoplasms; DNA-(Apurinic or Apyrimidinic Site) Lyase; Genetic Heterogeneity; Glutamic Acid; Humans | 2015 |
Mechanisms Underlying Astrocyte Endfeet Swelling in Stroke.
Topics: Animals; Aspartic Acid; Astrocytes; Blood-Brain Barrier; Brain Ischemia; Cell Size; Edema; Glutamic Acid; Humans; Potassium; Stroke | 2016 |
AGC1/2, the mitochondrial aspartate-glutamate carriers.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Biological Transport, Active; Calcium-Binding Proteins; Cattle; Consensus Sequence; Glutamic Acid; Humans; Malates; Mice; Mitochondria; Mitochondrial Membrane Transport Proteins; Models, Molecular; NAD; Neoplasm Proteins; Organ Specificity; Organic Anion Transporters; Oxidation-Reduction; Protein Conformation; Sequence Alignment; Sequence Homology, Amino Acid | 2016 |
Vanishing pineal mass in a young patient without therapy: Case report and review of the literature.
Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Choline; Electroencephalography; Female; Glutamic Acid; Glutamine; Headache; Humans; Hydrocephalus; Magnetic Resonance Imaging; Pineal Gland; Pinealoma; Recovery of Function; Tomography, X-Ray Computed | 2016 |
Clinical magnetic resonance spectroscopy of the central nervous system.
Topics: Aspartic Acid; Brain Chemistry; Brain Neoplasms; Central Nervous System; Choline; Creatine; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy | 2016 |
The use of magnetic resonance spectroscopy for assessing the effect of diet on cognition.
Topics: Aspartic Acid; Brain; Choline; Cognition; Creatine; Diet; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neurotransmitter Agents; Taurine | 2018 |
Essential Tremor with Aspartic Acidemia.
Topics: Acidosis; Adult; Aged; Aspartic Acid; Biomarkers; Essential Tremor; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Male; Predictive Value of Tests | 2017 |
Magnetic resonance spectroscopy and magnetic resonance spectroscopic imaging in Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy: A literature review.
Topics: Aspartic Acid; Brain; CADASIL; Creatine; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Magnetic Resonance Spectroscopy; Proton Magnetic Resonance Spectroscopy | 2017 |
Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic review.
Topics: Antimanic Agents; Aspartic Acid; Bipolar Disorder; Brain; Choline; Cross-Sectional Studies; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Lithium Compounds; Proton Magnetic Resonance Spectroscopy; Treatment Outcome | 2018 |
Metabolomics in patients with psychosis: A systematic review.
Topics: 3-Hydroxybutyric Acid; Aspartic Acid; Biomarkers; Bipolar Disorder; Creatine; Female; Glutamic Acid; Glutathione; Humans; Kynurenine; Lactic Acid; Linoleic Acid; Male; Metabolome; Metabolomics; Psychotic Disorders; Schizophrenia; Serine; Tryptophan | 2018 |
Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Depression; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Synaptic Transmission | 2019 |
Current Practice and New Developments in the Use of In Vivo Magnetic Resonance Spectroscopy for the Assessment of Key Metabolites Implicated in the Pathophysiology of Schizophrenia.
Topics: Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Humans; Magnetic Resonance Spectroscopy; Schizophrenia | 2018 |
The nucleus reuniens of the thalamus sits at the nexus of a hippocampus and medial prefrontal cortex circuit enabling memory and behavior.
Topics: Animals; Aspartic Acid; Brain Waves; CA1 Region, Hippocampal; Cortical Synchronization; Executive Function; Glutamic Acid; Humans; Interneurons; Maze Learning; Memory, Short-Term; Midline Thalamic Nuclei; Nerve Net; Neural Pathways; Neurons; Prefrontal Cortex; Rats; Spatial Navigation; Synaptic Transmission | 2019 |
Glutamate transporters: a broad review of the most recent archaeal and human structures.
Topics: Amino Acid Transport System X-AG; Archaea; Aspartic Acid; Binding Sites; Chlorides; Glutamic Acid; Humans; Potassium; Protein Conformation; Sodium | 2019 |
Mitochondrial Carriers for Aspartate, Glutamate and Other Amino Acids: A Review.
Topics: Amino Acids; Arabidopsis Proteins; Aspartic Acid; Biological Transport; Glutamic Acid; Humans; Mitochondrial Membrane Transport Proteins; Mitochondrial Membranes; Phylogeny; Saccharomyces cerevisiae Proteins | 2019 |
Magnetic resonance spectroscopy studies in subjects with high risk for psychosis: A meta-analysis and review.
Topics: Aspartic Acid; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Schizophrenia | 2020 |
Treatment effects on neurometabolite levels in schizophrenia: A systematic review and meta-analysis of proton magnetic resonance spectroscopy studies.
Topics: Aspartic Acid; Glutamic Acid; Glutamine; Humans; Proton Magnetic Resonance Spectroscopy; Schizophrenia; Thalamus | 2020 |
Brain Branched-Chain Amino Acids in Maple Syrup Urine Disease: Implications for Neurological Disorders.
Topics: Amino Acids, Branched-Chain; Aspartic Acid; Brain; Central Nervous System; Disease Susceptibility; Glutamic Acid; Humans; Lactic Acid; Maple Syrup Urine Disease; Metabolic Networks and Pathways; Nervous System Diseases | 2020 |
A role for endothelial NMDA receptors in the pathophysiology of schizophrenia.
Topics: Aspartic Acid; Brain; Glutamic Acid; Humans; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2022 |
The contributions of metabolomics in the discovery of new therapeutic targets in Alzheimer's disease.
Topics: Alanine; Alzheimer Disease; Animals; Arginine; Aspartic Acid; Biomarkers; Disease Models, Animal; Glutamic Acid; Humans; Metabolomics; Rats | 2021 |
Glutamate and N-Acetylaspartate Alterations Observed in Early Phase Psychosis: A Systematic Review of Proton Magnetic Resonance Spectroscopy Studies.
Topics: Aspartic Acid; Female; Glutamic Acid; Glutamine; Humans; Male; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders | 2022 |
Brain metabolite alterations related to alcohol use: a meta-analysis of proton magnetic resonance spectroscopy studies.
Topics: Alcoholism; Aspartic Acid; Brain; Choline; Glutamic Acid; Humans; Proton Magnetic Resonance Spectroscopy | 2022 |
Glutamatergic and N-Acetylaspartate Metabolites in Bipolar Disorder: A Systematic Review and Meta-Analysis of Proton Magnetic Resonance Spectroscopy Studies.
Topics: Aspartic Acid; Bipolar Disorder; Depressive Disorder, Major; Glutamic Acid; Glutamine; Humans; Proton Magnetic Resonance Spectroscopy | 2022 |
The Role of D-Serine and D-Aspartate in the Pathogenesis and Therapy of Treatment-Resistant Schizophrenia.
Topics: Aspartic Acid; D-Aspartic Acid; Glutamic Acid; Humans; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenia, Treatment-Resistant; Serine | 2022 |
Neurometabolite levels in the brains of patients with autism spectrum disorders: A meta-analysis of proton magnetic resonance spectroscopy studies (N = 1501).
Topics: Aspartic Acid; Autism Spectrum Disorder; Brain; Choline; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Proton Magnetic Resonance Spectroscopy | 2023 |
Aspartate-glutamate carrier 2 (citrin): a role in glucose and amino acid metabolism in the liver.
Topics: Aspartic Acid; Glucose; Glutamic Acid; Liver | 2023 |
Brain metabolic derangements examined using
Topics: Animals; Aspartic Acid; Brain; Depression; Depressive Disorder, Major; Glutamic Acid; Glutamine; Proton Magnetic Resonance Spectroscopy; Rodentia | 2023 |
62 trial(s) available for aspartic acid and glutamic acid
| Article | Year |
|---|---|
N-methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia?
Topics: Aspartic Acid; Brain; Brain Ischemia; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Models, Neurological; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1989 |
Effect of sucrose ingestion on plasma glutamate concentrations in humans administered monosodium L-glutamate.
Topics: Administration, Oral; Adult; Alanine; Analysis of Variance; Aspartic Acid; Blood; Blood Glucose; Female; Glutamates; Glutamic Acid; Humans; Male; Sodium Glutamate; Sucrose | 1986 |
Aspartame-sweetened beverage: effect on plasma amino acid concentrations in normal adults and adults heterozygous for phenylketonuria.
Topics: Adult; Amino Acids; Asparagine; Aspartame; Aspartic Acid; Beverages; Biological Transport; Dipeptides; Female; Glutamates; Glutamic Acid; Glutamine; Heterozygote; Humans; Kinetics; Male; Phenylalanine; Phenylketonurias; Tyrosine | 1987 |
Effects of a parenteral nutrition regimen containing dicarboxylic amino acids on plasma, erythrocyte, and urinary amino acid concentrations of young infants.
Topics: Amino Acids; Amino Acids, Dicarboxylic; Aspartic Acid; Erythrocytes; Female; Glutamates; Glutamic Acid; Glutamine; Humans; Infant, Newborn; Male; Nitrogen; Parenteral Nutrition | 1983 |
Amino acid-enriched glucose-insulin-potassium infusion improves hemodynamic function after coronary bypass surgery. A double-blind study in patients with unstable angina and/or compromised left ventricular function.
Topics: Aged; Amino Acids; Angina, Unstable; Aspartic Acid; Cardioplegic Solutions; Coronary Artery Bypass; Double-Blind Method; Female; Glucose; Glutamic Acid; Hemodynamics; Humans; Insulin; Male; Middle Aged; Myocardial Reperfusion Injury; Potassium; Prospective Studies; Stroke Volume; Ventricular Function, Left | 1995 |
Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose.
Topics: Adult; Amino Acids; Aspartic Acid; Blood Glucose; Brain; Carbon Isotopes; Female; Glucose; Glutamic Acid; Humans; Isotope Labeling; Magnetic Resonance Spectroscopy; Male; Reference Values; Time Factors | 1994 |
Blood cardioplegia with warm reperfusion versus intermittent aortic crossclamping in myocardial revascularization. Randomized controlled trial.
Topics: Aorta; Aspartic Acid; Blood; Cardioplegic Solutions; Constriction; Coronary Artery Bypass; Creatine Kinase; Female; Glutamates; Glutamic Acid; Heart Arrest, Induced; Hemodynamics; Humans; Isoenzymes; Male; Middle Aged; Myocardial Reperfusion; Postoperative Complications; Temperature | 1993 |
Aspartate and glutamate modulation of growth hormone secretion in the pig: possible site of action.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Aspartic Acid; Body Weight; Cells, Cultured; Dose-Response Relationship, Drug; Female; Glutamic Acid; Growth Hormone; Growth Hormone-Releasing Hormone; N-Methylaspartate; Ovariectomy; Pituitary Gland, Anterior; Serum Albumin; Swine | 1996 |
Changes in myocardial concentration of glutamate and aspartate during coronary artery surgery.
Topics: Adenosine Triphosphate; Alanine; Amino Acids; Aspartic Acid; Bicarbonates; Biopsy; Blood; Calcium Chloride; Cardioplegic Solutions; Cardiopulmonary Bypass; Coronary Artery Bypass; Female; Glutamic Acid; Humans; Magnesium; Male; Middle Aged; Myocardium; Potassium Chloride; Sodium Chloride; Troponin; Troponin I; Troponin T | 1997 |
Excitatory amino acid levels in cerebrospinal fluid of patients with infantile spasms.
Topics: Aspartic Acid; Child, Preschool; Chromatography, High Pressure Liquid; Excitatory Amino Acids; Female; Glutamic Acid; Humans; Infant; Linear Models; Male; Reference Values; Sensitivity and Specificity; Spasms, Infantile; Turkey | 1997 |
Central effects of acamprosate: part 2. Acamprosate modifies the brain in-vivo proton magnetic resonance spectrum in healthy young male volunteers.
Topics: Acamprosate; Adult; Alcohol Deterrents; Aspartic Acid; Brain; Creatine; Cross-Over Studies; Dipeptides; Double-Blind Method; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Taurine | 1998 |
Glycine and other neurotransmitter amino acids in cerebrospinal fluid in perinatal asphyxia and neonatal hypoxic-ischaemic encephalopathy.
Topics: Analysis of Variance; Aspartic Acid; Asphyxia Neonatorum; Chi-Square Distribution; Chromatography, High Pressure Liquid; Electroencephalography; Female; Glutamic Acid; Glycine; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Neurotransmitter Agents; Prognosis; Reference Values; Sensitivity and Specificity; Severity of Illness Index; Spinal Puncture; Taurine | 1999 |
Quantitative analysis of short echo time (1)H-MRSI of cerebral gray and white matter.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Calibration; Cerebrospinal Fluid; Choline; Creatine; Dipeptides; Epilepsy; Female; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Phantoms, Imaging; Regression Analysis; Sensitivity and Specificity | 2000 |
Quantitative short echo time proton magnetic resonance spectroscopic imaging study of malformations of cortical development causing epilepsy.
Topics: Adult; Analysis of Variance; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Dipeptides; Epilepsy; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Male; Middle Aged; Nervous System Malformations; Phosphocreatine; Reference Values | 2001 |
Aging alters regional multichemical profile of the human brain: an in vivo 1H-MRS study of young versus middle-aged subjects.
Topics: Adult; Age Factors; Aging; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Reference Values | 2001 |
Aging alters the multichemical networking profile of the human brain: an in vivo (1)H-MRS study of young versus middle-aged subjects.
Topics: Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Net; Organ Specificity | 2001 |
Direct determination of the N-acetyl-L-aspartate synthesis rate in the human brain by (13)C MRS and [1-(13)C]glucose infusion.
Topics: Adult; Amidohydrolases; Aspartic Acid; Brain; Canavan Disease; Carbon Isotopes; Child, Preschool; Glucose; Glutamic Acid; Humans; Infusions, Intravenous; Intubation, Gastrointestinal; Magnetic Resonance Spectroscopy; Predictive Value of Tests | 2001 |
Is glutamine beneficial in ischemic heart disease?
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Administration, Oral; Aged; Angina Pectoris; Animals; Aspartic Acid; Cardiac Output; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Exercise Test; Glutamic Acid; Glutamine; Glutathione; Heart; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Rats; Rats, Sprague-Dawley; Time Factors | 2002 |
Motor unit hyperexcitability in amyotrophic lateral sclerosis vs amino acids acting as neurotransmitters.
Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Electromyography; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Motor Neurons; Muscle, Skeletal; Neurotransmitter Agents; Reference Values | 2002 |
Effect of Riluzole on serum amino acids in patients with amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Neurotransmitter Agents; Reference Values; Riluzole; Time | 2002 |
Brain metabolite composition during early human brain development as measured by quantitative in vivo 1H magnetic resonance spectroscopy.
Topics: Aspartic Acid; Brain; Brain Chemistry; Choline; Embryonic and Fetal Development; Female; Gestational Age; Glutamic Acid; Glutathione; Humans; Infant; Infant, Newborn; Infant, Premature; Inositol; Magnetic Resonance Spectroscopy; Male; Pregnancy; Pregnancy Trimester, Third; Reference Values; Sensitivity and Specificity | 2002 |
Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging.
Topics: Adult; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Dipeptides; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Oligodendroglioma; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Elevated extracellular levels of glutamate, aspartate and gamma-aminobutyric acid within the intraoperative, spontaneously epileptiform human hippocampus.
Topics: Adult; Anesthesia, General; Aspartic Acid; Electroencephalography; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; Intraoperative Period; Male | 2003 |
A double-blind randomized clinical trial in amyotrophic lateral sclerosis using lamotrigine: effects on CSF glutamate, aspartate, branched-chain amino acid levels and clinical parameters.
Topics: Adult; Aged; Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cross-Over Studies; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Lamotrigine; Male; Middle Aged; Outcome Assessment, Health Care; Triazines | 2003 |
Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Carnosine; Epilepsy, Generalized; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Reference Values; Valproic Acid | 2003 |
[The effect of glutamate and aspartate on myocardial protection at cardiopulmonary bypass].
Topics: Aspartic Acid; Cardioplegic Solutions; Cardiovascular Diseases; Coronary Artery Bypass; Creatine Kinase; Creatine Kinase, MB Form; Female; Glutamic Acid; Heart Arrest, Induced; Humans; Isoenzymes; Male; Middle Aged; Myocardial Reperfusion Injury; Treatment Outcome; Troponin | 2004 |
Creatine supplementation lowers brain glutamate levels in Huntington's disease.
Topics: Administration, Oral; Adult; Aspartic Acid; Brain; Cerebral Cortex; Creatine; Down-Regulation; Energy Metabolism; Female; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurologic Examination; Neuroprotective Agents; Pilot Projects; Treatment Outcome | 2005 |
Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosis.
Topics: Adult; Age of Onset; Aged; Aspartic Acid; Biomarkers; Case-Control Studies; Cerebral Cortex; Choline; Disability Evaluation; Disease Progression; Female; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Nerve Fibers, Myelinated; Neurons; Neuropil; Phosphocreatine; Predictive Value of Tests; Reference Values; Statistics as Topic | 2005 |
Assessment of glutamate and glutamine contribution to in vivo N-acetylaspartate quantification in human brain by (1)H-magnetic resonance spectroscopy.
Topics: Algorithms; Aspartic Acid; Biomarkers; Brain; Diagnosis, Computer-Assisted; Female; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Excitatory amino acids and magnesium sulfate in neonatal asphyxia.
Topics: Anticonvulsants; Aspartic Acid; Asphyxia Neonatorum; Female; Glutamic Acid; Humans; Hypoxia, Brain; Infant, Newborn; Magnesium Sulfate; Male; Prospective Studies; Severity of Illness Index; Treatment Failure | 2006 |
Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma.
Topics: Adenoma; Aged; Alleles; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Case-Control Studies; Colonic Neoplasms; Female; Genetic Variation; Genotype; Glutamic Acid; Glycine; Haplotypes; Humans; Ibuprofen; Leucine; Lysine; Male; Methionine; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Racemases and Epimerases; Rectal Neoplasms; Serine; Valine | 2007 |
Glutamate/aspartate supplementation during cardiopulmonary bypass: effect on postoperative neurocognitive function.
Topics: Aged; Aspartic Acid; Cardiopulmonary Bypass; Cognition; Cognition Disorders; Dietary Supplements; Female; Glutamic Acid; Health Status Indicators; Humans; Incidence; Male; Middle Aged; Postoperative Complications; Postpartum Period; Psychological Tests; Psychometrics; Risk Factors | 2008 |
MR spectroscopy in monitoring the treatment of Wilson's disease patients.
Topics: Adolescent; Adult; Antidotes; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Follow-Up Studies; Glutamic Acid; Hepatolenticular Degeneration; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Penicillamine; Protons; Severity of Illness Index; Young Adult | 2008 |
Adaptation to a long term (4 weeks) arginine- and precursor (glutamate, proline and aspartate)-free diet.
Topics: Adult; Analysis of Variance; Arginine; Aspartic Acid; Carbon Isotopes; Citrulline; Diet; Dietary Proteins; Female; Glutamic Acid; Homeostasis; Humans; Infusions, Intravenous; Isotope Labeling; Kinetics; Leucine; Male; Nitrogen Isotopes; Oxidation-Reduction; Proline; Time Factors; Urea | 2008 |
Proton MR spectroscopy of metabolite concentrations in temporal lobe epilepsy and effect of temporal lobe resection.
Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Brain Mapping; Carnosine; Creatine; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Young Adult | 2009 |
Increased glutamate in the hippocampus after galantamine treatment for Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Mapping; Choline; Cholinesterase Inhibitors; Creatine; Female; Galantamine; Glutamic Acid; Hippocampus; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Neuropsychological Tests; Regression Analysis | 2010 |
Effects of short-term stress-like cortisol on cerebral metabolism: a proton magnetic resonance spectroscopy study at 3.0 T.
Topics: Adult; Analysis of Variance; Anti-Inflammatory Agents; Aspartic Acid; Brain; Creatine; Cross-Over Studies; Double-Blind Method; Glutamic Acid; Humans; Hydrocortisone; Inositol; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Protons; Stress, Psychological; Time Factors; Young Adult | 2010 |
Hypothalamic glutamate levels following serotonergic stimulation: a pilot study using 7-Tesla magnetic resonance spectroscopy in healthy volunteers.
Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Adult; Aspartic Acid; Carbidopa; Choline; Dopamine Agents; Double-Blind Method; Glutamic Acid; Glutamine; Granisetron; Humans; Hypothalamus; Magnetic Resonance Spectroscopy; Male; Pilot Projects; Serotonin Agents; Time Factors; Young Adult | 2010 |
Effect of oral arginine supplementation on exhaled nitric oxide concentration in sickle cell anemia and acute chest syndrome.
Topics: Acute Chest Syndrome; Acute Disease; Administration, Oral; Adolescent; Anemia, Sickle Cell; Arginine; Aspartic Acid; Breath Tests; Child; Citrulline; Female; Glutamic Acid; Humans; Male; Nitrates; Nitric Oxide; Nitrites; Ornithine; Young Adult | 2010 |
Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain.
Topics: Adult; Analgesia; Aspartic Acid; Brain; Chronic Disease; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pain; Pain Management; Pancreatitis, Chronic; Radionuclide Imaging; Severity of Illness Index; Somatosensory Cortex; Transcranial Magnetic Stimulation; Treatment Outcome | 2011 |
The acute and late CNS glutamine response to benzodiazepine challenge: a pilot pharmacokinetic study using proton magnetic resonance spectroscopy.
Topics: Adult; Alprazolam; Aspartic Acid; Benzodiazepines; Brain Mapping; Central Nervous System; Choline; Clonazepam; Creatine; Cross-Over Studies; Double-Blind Method; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Hypnotics and Sedatives; Magnetic Resonance Spectroscopy; Male; Pilot Projects; Protons; Time Factors; Young Adult | 2010 |
Brainstem metabolites in multiple system atrophy of cerebellar type: 3.0-T magnetic resonance spectroscopy study.
Topics: Aged; Aspartic Acid; Biomarkers; Choline; Creatinine; Dipeptides; Feasibility Studies; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Medulla Oblongata; Middle Aged; Multiple System Atrophy; Pons; Protons; Severity of Illness Index | 2011 |
Proton magnetic resonance spectroscopy study of brain metabolite changes after antipsychotic treatment.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Brain; Brain Chemistry; Diagnostic and Statistical Manual of Mental Disorders; Female; Follow-Up Studies; Fourier Analysis; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurons; Psychiatric Status Rating Scales; Schizophrenia; Thalamus; Young Adult | 2011 |
Metabolic abnormalities in pain-processing regions of patients with fibromyalgia: a 3T MR spectroscopy study.
Topics: Adult; Aspartic Acid; Choline; Chronic Pain; Creatinine; Dipeptides; Female; Fibromyalgia; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Thalamus | 2011 |
Effects of motor cortex modulation and descending inhibitory systems on pain thresholds in healthy subjects.
Topics: Adolescent; Adult; Afferent Pathways; Analysis of Variance; Aspartic Acid; Cold Temperature; Double-Blind Method; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Neural Inhibition; Neuropsychological Tests; Pain Measurement; Pain Threshold; Touch; Transcranial Magnetic Stimulation; Young Adult | 2012 |
Glutamate normalization with ECT treatment response in major depression.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Depressive Disorder, Major; Electroconvulsive Therapy; Female; Glutamic Acid; Gyrus Cinguli; Humans; Male | 2013 |
Riluzole effect on occipital cortex: a structural and spectroscopy pilot study.
Topics: Adult; Anti-Anxiety Agents; Anxiety Disorders; Aspartic Acid; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Pilot Projects; Riluzole; Treatment Outcome | 2012 |
Cingulate biochemistry in heroin users on substitution pharmacotherapy.
Topics: Adult; Aspartic Acid; Buprenorphine; Depression; Dose-Response Relationship, Drug; Female; Functional Neuroimaging; Glutamic Acid; Glutamine; Gyrus Cinguli; Heroin Dependence; Humans; Inositol; Male; Methadone; Opiate Substitution Treatment | 2013 |
Metabolite profiles in the anterior cingulate cortex of depressed patients differentiate those taking N-acetyl-cysteine versus placebo.
Topics: Acetylcysteine; Aspartic Acid; Depressive Disorder, Major; Double-Blind Method; Female; Free Radical Scavengers; Functional Neuroimaging; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Male; Middle Aged; Oxidative Stress | 2013 |
Low single dose gabapentin does not affect prefrontal and occipital gamma-aminobutyric acid concentrations.
Topics: Adult; Amines; Analysis of Variance; Anticonvulsants; Aspartic Acid; Choline; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Female; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Prefrontal Cortex; Young Adult | 2013 |
Anterior cingulate cortex and cerebellar hemisphere neurometabolite changes in depression treatment: A 1H magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Antidepressive Agents; Aspartic Acid; Cerebellum; Choline; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Male; Middle Aged; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; Young Adult | 2014 |
Changes in metabolites after treatment with memantine in fibromyalgia. A double-blind randomized controlled trial with magnetic resonance spectroscopy with a 6-month follow-up.
Topics: Adult; Aspartic Acid; Brain; Creatine; Dopamine Agents; Double-Blind Method; Female; Fibromyalgia; Follow-Up Studies; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memantine; Mental Status Schedule; Middle Aged; Surveys and Questionnaires; Treatment Outcome | 2014 |
Excitatory and inhibitory brain metabolites as targets of motor cortex transcranial direct current stimulation therapy and predictors of its efficacy in fibromyalgia.
Topics: Adult; Aspartic Acid; Brain; Female; Fibromyalgia; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Longitudinal Studies; Middle Aged; Motor Cortex; Pain Measurement; Proton Magnetic Resonance Spectroscopy; Transcranial Direct Current Stimulation; Treatment Outcome | 2015 |
Supplementation of antipsychotic treatment with sarcosine – GlyT1 inhibitor – causes changes of glutamatergic (1)NMR spectroscopy parameters in the left hippocampus in patients with stable schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Double-Blind Method; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Humans; Inositol; Male; Middle Aged; Sarcosine; Schizophrenia; Young Adult | 2015 |
Online Effects of Transcranial Direct Current Stimulation in Real Time on Human Prefrontal and Striatal Metabolites.
Topics: Adult; Aspartic Acid; Corpus Striatum; Double-Blind Method; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Healthy Volunteers; Humans; Magnetic Resonance Spectroscopy; Male; Prefrontal Cortex; Transcranial Direct Current Stimulation; Young Adult | 2016 |
Online effects of transcranial direct current stimulation on prefrontal metabolites in gambling disorder.
Topics: Aspartic Acid; Cross-Over Studies; Double-Blind Method; Electroencephalography; Female; Gambling; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Online Systems; Prefrontal Cortex; Transcranial Direct Current Stimulation | 2018 |
Intralipid/Heparin Infusion Alters Brain Metabolites Assessed With 1H-MRS Spectroscopy in Young Healthy Men.
Topics: Adult; Anticoagulants; Aspartic Acid; Brain; Choline; Creatine; Emulsions; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Healthy Volunteers; Heparin; Hippocampus; Humans; Inositol; Male; Phospholipids; Proton Magnetic Resonance Spectroscopy; Soybean Oil | 2018 |
Effects of infliximab on brain neurochemistry of adults with bipolar depression.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Brain; Glutamic Acid; Humans; Infliximab; Neurochemistry; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy | 2021 |
Dietary glutamic acid and aspartic acid as biomarkers for predicting diabetic retinopathy.
Topics: Aged; Aspartic Acid; Biomarkers; Diabetic Retinopathy; Dietary Supplements; Energy Intake; Female; Glutamic Acid; Humans; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Republic of Korea | 2021 |
Effects of Five Amino Acids (Serine, Alanine, Glutamate, Aspartate, and Tyrosine) on Mental Health in Healthy Office Workers: A Randomized, Double-Blind, Placebo-Controlled Exploratory Trial.
Topics: Adult; Aged; Alanine; Amino Acids; Aspartic Acid; Double-Blind Method; Glutamic Acid; Humans; Mental Fatigue; Mental Health; Middle Aged; Occupational Health; Serine; Treatment Outcome; Tyrosine; Young Adult | 2022 |
Metabolomics strategy comprehensively unveils the effect of catechins intervention on the biomarkers of exposure to acrylamide and biomarkers of cardiometabolic risk.
Topics: Acrylamide; Adult; Alanine; Animals; Antioxidants; Aspartic Acid; Biomarkers; Capsules; Cardiovascular Diseases; Catechin; Citric Acid; Glutamic Acid; Glutamine; Glycolipids; Humans; Ketoglutaric Acids; Metabolomics; Phenylalanine; Polyphenols; Rats; Tea | 2022 |
Plasma Amino Acid Neurotransmitters and Ischemic Stroke Prognosis: A Multicenter Prospective Study.
Topics: Aspartic Acid; Biomarkers; Brain Ischemia; Cohort Studies; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Ischemic Stroke; Prognosis; Prospective Studies; Risk Factors; Stroke | 2023 |
4149 other study(ies) available for aspartic acid and glutamic acid
| Article | Year |
|---|---|
DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy.
Topics: Animals; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Molecular Structure; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tetrazoles | 1992 |
Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists.
Topics: Binding, Competitive; Isoquinolines; Models, Molecular; Molecular Conformation; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1992 |
Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives.
Topics: Amino Acids; Humans; Mathematics; Peptides; Structure-Activity Relationship; Taste | 1987 |
13N-labeled L-amino acids for in vivo assessment of local myocardial metabolism.
Topics: Amino Acids; Animals; Citric Acid Cycle; Coronary Disease; Dogs; Half-Life; Myocardium; Nitrogen Radioisotopes | 1981 |
A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Magnetic Resonance Spectroscopy; Molecular Structure; N-Methylaspartate; Receptors, Metabotropic Glutamate | 1996 |
Prediction of the GTPase activities by using the semiempirical molecular orbital theory.
Topics: Amino Acid Substitution; Chemistry, Physical; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Hydrolysis; Kinetics; Models, Chemical; Mutagenesis, Site-Directed; Proto-Oncogene Proteins p21(ras); Thermodynamics | 1998 |
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis | 2001 |
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Topics: Amino Acid Motifs; Amino Acid Transport Systems; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Ligands; Models, Molecular; Mutation; Protein Conformation; Protein Subunits; Pyrococcus horikoshii; Sodium; Substrate Specificity; Thermodynamics | 2007 |
Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.
Topics: Amino Acid Transport Systems; Amino Acids; Biological Transport; Catalytic Domain; Dipeptides; Gene Expression Regulation, Fungal; Mutagenesis; Protein Conformation; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction | 2009 |
Tissue distribution and identification of radioactivity components at elimination phase after oral administration of [¹⁴C]CS-1036, an α-amylase inhibitor, to rats.
Topics: Administration, Oral; alpha-Amylases; Amino Acids; Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Disaccharides; Enzyme Inhibitors; Fatty Acids; Hydrolysis; Male; Pyrrolidines; Radiometry; Rats; Rats, Inbred F344; Tissue Distribution | 2013 |
Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors.
Topics: Ammonia-Lyases; Aspartic Acid; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Excitatory Amino Acid Transporter 4; Glutamate Plasma Membrane Transport Proteins; HEK293 Cells; Humans; Molecular Structure; Structure-Activity Relationship | 2018 |
Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
Topics: Amino Acid Transport Systems; Antiporters; Escherichia coli Proteins; HEK293 Cells; Humans; Large Neutral Amino Acid-Transporter 1; Ligands; Molecular Docking Simulation; Phenylalanine; Stereoisomerism; Structural Homology, Protein; Structure-Activity Relationship; Substrate Specificity | 2018 |
Immunocytochemistry of oculomotor afferents in the squirrel monkey (Saimiri sciureus).
Topics: Animals; Aspartic Acid; Benzidines; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Gold Colloid, Radioactive; Horseradish Peroxidase; Immunohistochemistry; Neurons, Afferent; Oculomotor Nerve; Saimiri; Staining and Labeling; Vestibular Nuclei; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1992 |
The cortical lesion of Huntington's disease: further neurochemical characterization, and reproduction of some of the histological and neurochemical features by N-methyl-D-aspartate lesions of rat cortex.
Topics: Age Factors; Aged; Animals; Aspartic Acid; Brain Chemistry; Cholecystokinin; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Humans; Huntington Disease; Male; Middle Aged; N-Methylaspartate; Neurochemistry; Rats; Rats, Sprague-Dawley; Somatostatin; Substance P | 1992 |
Transmitter substances contained in the petrosal ganglion cells determined by a double-labeling method in the rat.
Topics: Animals; Aspartic Acid; Ganglia; Glutamates; Glutamic Acid; Histocytochemistry; Horseradish Peroxidase; Male; Neurotransmitter Agents; Rats; Rats, Wistar; Substance P | 1992 |
Anion channels for amino acids in MDCK cells.
Topics: Amino Acids; Animals; Anions; Aspartic Acid; Cell Line; Dogs; Electric Conductivity; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Ion Channels; Kidney; Taurine | 1992 |
Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy.
Topics: Aspartic Acid; Brain; Choline; Female; Glucose; Glutamates; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Inositol; Liver Diseases; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phosphocreatine; Reproducibility of Results | 1992 |
Physiological levels of ammonia regulate glutamine synthesis from extracellular glutamate in astrocyte cultures.
Topics: Ammonia; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Extracellular Space; Glutamates; Glutamic Acid; Glutamine; Kinetics | 1992 |
Depression by sodium ions of calcium uptake mediated by non-N-methyl-D-aspartate receptors in cultured cerebellar neurons and correlation with evoked D-[3H]aspartate release.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Ions; Kainic Acid; Neurons; Quisqualic Acid; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Tritium | 1992 |
Glutamate uptake disguises neurotoxic potency of glutamate agonists in cerebral cortex in dissociated cell culture.
Topics: Animals; Aspartic Acid; Astrocytes; Biological Transport; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; N-Methylaspartate; Rats; Sodium; Stereoisomerism | 1992 |
Probing the active site of the reconstituted aspartate/glutamate carrier from bovine heart mitochondria: carbodiimide-catalyzed acylation of a functional lysine residue.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Acylation; Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Binding Sites; Biological Transport; Carrier Proteins; Catalysis; Cattle; Diethyl Pyrocarbonate; Electrophoresis, Polyacrylamide Gel; Ethyldimethylaminopropyl Carbodiimide; Glutamates; Glutamic Acid; Kinetics; Lysine; Mitochondria, Heart; Proteolipids; Pyridoxal Phosphate | 1992 |
Functional relationships between cyclodextrin glucanotransferase from an alkalophilic Bacillus and alpha-amylases. Site-directed mutagenesis of the conserved two Asp and one Glu residues.
Topics: alpha-Amylases; Aspartic Acid; Bacillus; Base Sequence; Binding Sites; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Glucosyltransferases; Glutamates; Glutamic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed | 1992 |
Different positively charged amino acids have similar effects on the topology of a polytopic transmembrane protein in Escherichia coli.
Topics: Amino Acid Sequence; Arginine; Aspartic Acid; Cell Membrane; Endopeptidases; Escherichia coli; Glutamates; Glutamic Acid; Lysine; Membrane Proteins; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Protein Conformation; Serine Endopeptidases | 1992 |
pH-dependent heterogeneity of acidic amino acid transport in rabbit jejunal brush border membrane vesicles.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Intestinal Mucosa; Jejunum; Kinetics; Microvilli; Rabbits | 1992 |
Relative role of the glutaminase, glutamate dehydrogenase, and AMP-deaminase pathways in hepatic ureagenesis: studies with 15N.
Topics: AMP Deaminase; Animals; Aspartic Acid; Cells, Cultured; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Isotope Labeling; Kinetics; Liver; Male; Nitrogen Isotopes; Rats; Rats, Inbred Strains; Urea | 1992 |
Substitution of glutamic acid 109 by aspartic acid alters the substrate specificity and catalytic activity of the beta-subunit in the tryptophan synthase bienzyme complex from Salmonella typhimurium.
Topics: Aspartic Acid; Base Sequence; Binding Sites; Catalysis; Glutamates; Glutamic Acid; Hydroxylamines; Molecular Sequence Data; Mutagenesis, Site-Directed; Salmonella typhimurium; Serine; Spectrophotometry; Substrate Specificity; Tryptophan; Tryptophan Synthase | 1992 |
Influence of the size and protonation state of acidic residue 85 on the absorption spectrum and photoreaction of the bacteriorhodopsin chromophore.
Topics: Aspartic Acid; Bacteriorhodopsins; Biological Transport; Escherichia coli; Glutamates; Glutamic Acid; Halobacterium; Hydrogen-Ion Concentration; Kinetics; Mutation; Photochemistry; Protons; Spectrophotometry, Ultraviolet; X-Ray Diffraction | 1992 |
Effects of ovarian steroids on the gonadotropin response to N-methyl-D-aspartate and on hypothalamic excitatory amino acid levels during sexual maturation in female rats.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Estrogens; Female; Follicle Stimulating Hormone; Glutamates; Glutamic Acid; Glycine; Gonadotropin-Releasing Hormone; Gonadotropins; Hypothalamus; Luteinizing Hormone; N-Methylaspartate; Ovary; Preoptic Area; Progesterone; Rats; Rats, Inbred Strains; Sexual Maturation | 1992 |
Two alloalbumins with identical electrophoretic mobility are produced by differently charged amino acid substitutions.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Genetic Variation; Glutamates; Glutamic Acid; Humans; Isoelectric Focusing; Lysine; Molecular Sequence Data; Mutation; Serum Albumin | 1992 |
Stabilization of the oxy form of tyrosinase by a single conservative amino acid substitution.
Topics: Amino Acid Sequence; Animals; Arthropods; Aspartic Acid; Base Sequence; Copper; Enzyme Stability; Glutamates; Glutamic Acid; Kinetics; Molecular Sequence Data; Monophenol Monooxygenase; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Conformation; Sequence Homology, Nucleic Acid; Spectrophotometry; Streptomyces | 1992 |
Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: effects of adenosine receptor agonists and antagonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Glutamates; Glutamic Acid; Male; Neurotransmitter Agents; Purinergic Antagonists; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Triazoles; Xanthines | 1992 |
Use of a dihydrogen osmium complex as a versatile 1H NMR recognition probe.
Topics: Amino Acids; Aspartic Acid; Deoxyribonucleotides; Ethylenediamines; Glutamates; Glutamic Acid; Hydrogen; Indicators and Reagents; Ligands; Magnetic Resonance Spectroscopy; Osmium; Ribonucleotides | 1992 |
Selective potentiation of NMDA-induced activity and release of excitatory amino acids by dynorphin: possible roles in paralysis and neurotoxicity.
Topics: Animals; Aspartic Acid; Behavior, Animal; Cell Death; Dizocilpine Maleate; Dynorphins; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurons; Paralysis; Rats; Rats, Inbred Strains; Spinal Cord | 1992 |
Uptake, metabolism, and release of N-[3H]acetylaspartylglutamate by the avian retina.
Topics: Animals; Aspartic Acid; Biological Transport; Chickens; Dipeptides; Glutamates; Glutamic Acid; Glutamine; Histamine H1 Antagonists; Retina; Time Factors; Tritium | 1992 |
Transport of acidic amino acids in Candida albicans.
Topics: Aspartic Acid; Binding, Competitive; Biological Transport; Candida albicans; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cycloheximide; Fungal Proteins; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics | 1992 |
Electrostatic interactions stabilizing ferredoxin electron transfer complexes. Disruption by "conservative" mutations.
Topics: Amino Acid Sequence; Aspartic Acid; Circular Dichroism; Electrochemistry; Electrons; Ferredoxins; Glutamates; Glutamic Acid; Humans; Molecular Sequence Data; Mutation; NADH Dehydrogenase; Spectrophotometry, Ultraviolet | 1992 |
Removal of the amino-terminal acidic residues of yeast actin. Studies in vitro and in vivo.
Topics: Acetylation; Actins; Amino Acid Sequence; Animals; Aspartic Acid; Autoradiography; Base Sequence; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Microscopy, Electron; Molecular Sequence Data; Muscles; Mutagenesis, Site-Directed; Myosins; Peptide Mapping; Rabbits; Saccharomyces cerevisiae | 1992 |
In vitro release of glutamate and aspartate from zebra finch song control nuclei.
Topics: Animals; Aspartic Acid; Birds; Calcium; Chromatography, High Pressure Liquid; Corpus Striatum; Electric Stimulation; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Nerve Fibers; Vocalization, Animal | 1992 |
1H spectroscopic imaging of rat brain at 7 tesla.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Glutamates; Glutamic Acid; Magnetic Resonance Spectroscopy; Phosphocreatine; Rats; Rats, Inbred F344 | 1992 |
Localized 1H NMR spectra of glutamate in the human brain.
Topics: Aspartic Acid; Cerebral Cortex; Creatine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy | 1992 |
Philanthotoxins block glutamatergic transmission in rat hippocampus--I. Reduction of high affinity glutamate uptake demonstrated by light microscopy surface autoradiography.
Topics: Animals; Aspartic Acid; Autoradiography; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Microscopy; Molecular Structure; Polyamines; Rats; Rats, Inbred Strains; Synaptic Transmission; Wasp Venoms | 1992 |
Characterization of putative neurotransmitter N-acetyl-aspartyl-glutamic acid and some related compounds by fast atom bombardment and tandem mass spectrometry.
Topics: Amino Acid Sequence; Aspartic Acid; Brain Chemistry; Dipeptides; Glutamates; Glutamic Acid; Mass Spectrometry; Molecular Sequence Data; Neurotransmitter Agents; Spectrometry, Mass, Fast Atom Bombardment | 1992 |
Ammonia-induced alterations in the metabolism of glutamate and aspartate in neuronal perikarya and synaptosomes of rat cerebellum.
Topics: Acetylcholinesterase; Ammonia; Animals; Aspartic Acid; Biomarkers; Butyrylcholinesterase; Carbon Dioxide; Cerebellum; Glutamates; Glutamic Acid; In Vitro Techniques; Neurons; Rats; Rats, Inbred Strains; Synaptosomes | 1992 |
Modulation of glutamate agonist-induced influx of calcium into neurons by gamma-L-glutamyl and beta-L-aspartyl dipeptides.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Dipeptides; Glutamates; Glutamic Acid; Neurons; Neuropeptides | 1992 |
Neuroanatomical evidence that vagal afferent nerves do not possess a high affinity uptake system for glutamate.
Topics: Afferent Pathways; Animals; Aspartic Acid; Binding, Competitive; Biological Transport; Glossopharyngeal Nerve; Glutamates; Glutamic Acid; Male; Medulla Oblongata; Neurons, Afferent; Rats; Rats, Inbred Strains; Trigeminal Ganglion; Trigeminal Nucleus, Spinal; Vagus Nerve | 1992 |
Adenosine receptor blockade augments interstitial fluid levels of excitatory amino acids during cerebral ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Glutamates; Glutamic Acid; Hypoxanthine; Hypoxanthines; Male; Neurotoxins; Purinergic Antagonists; Rats; Rats, Inbred Strains; Theophylline; Xanthine; Xanthines | 1992 |
Increased plasma glutamic acid in a genetic model of epilepsy.
Topics: Animals; Aspartic Acid; Disease Susceptibility; Epilepsy, Tonic-Clonic; Glutamates; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Models, Genetic; Taurine | 1992 |
Radioisotopic assay of aspartate and alanine aminotransferase.
Topics: Alanine Transaminase; Animals; Aspartic Acid; Carbon Radioisotopes; Female; Glutamates; Glutamic Acid; Humans; Ketoglutaric Acids; Radiometry; Rats; Scintillation Counting; Temperature | 1992 |
Concomitant increases in the extracellular concentrations of excitatory and inhibitory amino acids in the rat hippocampus during forebrain ischemia.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cell Death; Consciousness; Ethanolamines; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Hippocampus; Male; Neurotoxins; Prosencephalon; Rats; Rats, Inbred Strains; Taurine | 1992 |
Modulatory action of kainic acid on glutamate release from rat brain cortical synaptosomes.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Rats; Synaptosomes | 1992 |
Comparison of the release of exogenous and endogenous excitatory amino acids from rat cerebral cortex.
Topics: Animals; Aspartic Acid; Calcium; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Potassium; Radioisotope Dilution Technique; Rats; Tetrodotoxin; Tritium | 1992 |
N-acetyl-L-aspartate and other amino acid metabolites in Alzheimer's disease brain: a preliminary proton nuclear magnetic resonance study.
Topics: Aged; Alzheimer Disease; Amino Acids; Aspartic Acid; Brain; Cadaver; Female; Glutamates; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male | 1992 |
Striatal protection induced by lesioning the substantia nigra of rats subjected to focal ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Infarction; Corpus Striatum; Dopamine; Extracellular Space; Glutamates; Glutamic Acid; Male; Oxidopamine; Rats; Rats, Inbred Strains; Substantia Nigra | 1992 |
Regionally selective deficits in uptake sites for glutamate and gamma-aminobutyric acid in the basal ganglia in schizophrenia.
Topics: Aspartic Acid; Brain; Caudate Nucleus; Dominance, Cerebral; gamma-Aminobutyric Acid; Globus Pallidus; Glutamates; Glutamic Acid; Humans; Nipecotic Acids; Nucleus Accumbens; Proline; Putamen; Radioligand Assay; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter; Schizophrenia; Schizophrenic Psychology | 1992 |
Hypoxia increases extracellular concentrations of excitatory and inhibitory neurotransmitters in subsequently induced seizure: in vivo microdialysis study in the rabbit.
Topics: Animals; Aspartic Acid; Bicuculline; Brain; Dialysis; Electroencephalography; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hypoxia; Kinetics; Rabbits; Reference Values; Seizures; Taurine; Time Factors | 1992 |
Short echo time proton spectroscopy of human brain using a gradient head coil.
Topics: Adult; Aspartic Acid; Brain Chemistry; Cerebellum; Choline; Creatine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Mesencephalon; Middle Aged; Phosphocreatine; Taurine; Temporal Lobe | 1992 |
Release of endogenous amino acids, including homocysteic acid and cysteine sulphinic acid, from rat hippocampal slices evoked by electrical stimulation of Schaffer collateral-commissural fibres.
Topics: Amino Acids; Animals; Aspartic Acid; Cysteine; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Hippocampus; Homocysteine; In Vitro Techniques; Kinetics; Male; Methionine; Nerve Fibers; Neurotransmitter Agents; Pyramidal Tracts; Rats; Rats, Inbred Strains; Time Factors | 1992 |
Pertussis toxin pretreatment abolishes the inhibitory effect of riluzole and carbachol on D-[3H]aspartate release from cultured cerebellar granule cells.
Topics: Anesthetics; Aspartic Acid; Carbachol; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Humans; Pertussis Toxin; Riluzole; Thiazoles; Virulence Factors, Bordetella | 1992 |
Selective reduction of glutamate in the rat superior colliculus and dorsal lateral geniculate nucleus after contralateral enucleation.
Topics: Animals; Aspartic Acid; Eye Enucleation; Functional Laterality; gamma-Aminobutyric Acid; Geniculate Bodies; Glutamates; Glutamic Acid; Male; Rats; Rats, Inbred Strains; Reference Values; Superior Colliculi; Visual Cortex | 1992 |
In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat.
Topics: Amygdala; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dialysis; Electric Stimulation; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Reference Values; Time Factors | 1992 |
Regional variation of excitatory and inhibitory amino acid-induced responses in rat dissociated CNS neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Central Nervous System; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Neurons; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1992 |
Interaction between thyrotropin-releasing hormone (TRH) and NMDA-receptor-mediated responses in hypoglossal motoneurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Brain Stem; Evoked Potentials; Glutamates; Glutamic Acid; Guinea Pigs; Hypoglossal Nerve; In Vitro Techniques; Membrane Potentials; Motor Neurons; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Synapses; Tetrodotoxin; Thyrotropin-Releasing Hormone | 1992 |
Regulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum: in vivo microdialysis studies.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Extracellular Space; Fluorometry; Glutamates; Glutamic Acid; Kynurenic Acid; Male; N-Methylaspartate; Perfusion; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
Calcium-dependent release of glutamate from human cerebral cortex.
Topics: Aspartic Acid; Calcium; Cerebral Cortex; Glutamates; Glutamic Acid; Humans; In Vitro Techniques; Nerve Block; Synapses; Synaptic Transmission | 1992 |
N-methyl-D-aspartate exposure blocks glutamate toxicity in cultured cerebellar granule cells.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Culture Media; Cytoplasmic Granules; Excitatory Amino Acid Antagonists; Glucose; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Ouabain; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sensitivity and Specificity; Tritium | 1992 |
Interactions between valproate, glutamate, aspartate, and GABA with respect to uptake in astroglial primary cultures.
Topics: Animals; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kinetics; Rats; Rats, Inbred Strains; Valproic Acid | 1992 |
Effects of tizanidine on morphine physical dependence: attenuation and intensification.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Aspartic Acid; Behavior, Animal; Clonidine; Glutamates; Glutamic Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1992 |
Domoic acid-containing toxic mussels produce neurotoxicity in neuronal cultures through a synergism between excitatory amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Bivalvia; Cells, Cultured; Drug Synergism; Glutamates; Glutamic Acid; Kainic Acid; Marine Toxins; Neurons; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate | 1992 |
Systemic administration of baclofen and the GABAB antagonist, CGP 35348, does not affect GABA, glutamate or aspartate in microdialysates of the striatum of conscious rats.
Topics: Animals; Aspartic Acid; Baclofen; Corpus Striatum; Dialysis; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Organophosphorus Compounds; Potassium; Rats; Rats, Inbred Strains | 1992 |
Neurochemical changes associated with the action of acute administration of diazepam in reversing the behavioral paradigm conditioned emotional response (CER).
Topics: Amino Acids; Animals; Anxiety; Aspartic Acid; Behavior, Animal; Biogenic Monoamines; Brain; Conditioning, Psychological; Diazepam; Disease Models, Animal; Dopamine; Emotions; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Neurotransmitter Agents; Norepinephrine; Rats; Serotonin | 1992 |
Mechanistic consequences of mutation of the active site nucleophile Glu 358 in Agrobacterium beta-glucosidase.
Topics: Asparagine; Aspartic Acid; beta-Glucosidase; Binding Sites; Deuterium; Drug Stability; Glucosides; Glutamates; Glutamic Acid; Glutamine; Glycosylation; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Protein Conformation; Rhizobium; Structure-Activity Relationship | 1992 |
Reducing-equivalent transfer to the mitochondria during gluconeogenesis and ureogenesis in hepatocytes from rats of different thyroid status.
Topics: Alanine; Animals; Aspartic Acid; Biological Transport; Cells, Cultured; Cytoplasm; Gluconeogenesis; Glutamates; Glutamic Acid; Hydrogen; Hyperthyroidism; Hypothyroidism; Male; Malonates; Mitochondria, Liver; NAD; Pyruvates; Pyruvic Acid; Rats; Rats, Wistar; Thyroid Gland; Urea | 1992 |
Interactions of trimethyl tin (TMT) with rat primary astrocyte cultures: altered uptake and efflux of rubidium, L-glutamate and D-aspartate.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Rats; Rats, Sprague-Dawley; Rubidium; Trimethyltin Compounds; Water-Electrolyte Balance | 1992 |
Presynaptic inhibition by clonidine of neurotransmitter amino acid release in various brain regions.
Topics: Adrenergic alpha-Antagonists; Amino Acids; Animals; Aspartic Acid; Brain; Calcium; Clonidine; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Nerve Endings; Neurotransmitter Agents; Potassium; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Synaptosomes; Yohimbine | 1992 |
Tetanus toxin and botulinum toxins type A and B inhibit glutamate, gamma-aminobutyric acid, aspartate, and met-enkephalin release from synaptosomes. Clues to the locus of action.
Topics: Amino Acids; Animals; Aspartic Acid; Barium; Botulinum Toxins; Calcium; Enkephalin, Methionine; Exocytosis; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Neurotransmitter Agents; Synaptosomes; Tetanus Toxin | 1992 |
Amino acid neurotransmitter release in the preoptic area of rats during the positive feedback actions of estradiol on LH release.
Topics: Amino Acids; Animals; Aspartic Acid; Estradiol; Feedback; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Luteinizing Hormone; Neurotransmitter Agents; Ovariectomy; Preoptic Area; Rats; Rats, Sprague-Dawley; Taurine | 1992 |
5-(N-ethyl-N-isopropyl)amiloride and mild acidosis protect cultured cerebellar granule cells against glutamate-induced delayed neuronal death.
Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Aspartic Acid; Cell Death; Cells, Cultured; Cerebellum; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Magnesium; Membrane Potentials; Neurons; Quisqualic Acid; Rats; Rats, Wistar | 1992 |
The selective A2 adenosine receptor agonist CGS 21680 enhances excitatory transmitter amino acid release from the ischemic rat cerebral cortex.
Topics: Adenosine; Analysis of Variance; Animals; Antihypertensive Agents; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; Ischemic Attack, Transient; Kinetics; Male; Phenethylamines; Rats; Rats, Wistar; Receptors, Purinergic | 1992 |
AMPA and NMDA receptor antagonists do not decrease hippocampal glutamate concentrations during transient global ischemia.
Topics: Animals; Aspartic Acid; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Ischemic Attack, Transient; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reperfusion | 1992 |
Effects of acute alcohol intoxication on gluconeogenesis and its hormonal responsiveness in isolated, perfused rat liver.
Topics: Adenine Nucleotides; Alcoholic Intoxication; Animals; Aspartic Acid; Dinoprost; Dose-Response Relationship, Drug; Ethanol; Glucagon; Gluconeogenesis; Glucose; Glutamates; Glutamic Acid; Lactates; Liver; Malates; Male; Perfusion; Phenylephrine; Pyruvates; Rats; Rats, Sprague-Dawley | 1992 |
Kindling increases brain levels of NAAG and seizures reduce activity of a NAAG-hydrolyzing enzyme, NAALADase.
Topics: Amygdala; Animals; Aspartic Acid; Brain; Brain Mapping; Dipeptidases; Dipeptides; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamate Carboxypeptidase II; Glutamates; Glutamic Acid; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley; Seizures | 1992 |
Cholecystokinin is released from a crossed corticostriatal pathway.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Cholecystokinin; Corpus Striatum; Decerebrate State; Dialysis; Dopamine; Extracellular Space; Glutamates; Glutamic Acid; Male; Neural Pathways; Potassium; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques | 1992 |
Immunocytochemical and circadian biochemical analysis of neuroactive amino acids in the pineal gland of the rat: effect of superior cervical ganglionectomy.
Topics: Alanine; Analysis of Variance; Animals; Arginine; Aspartic Acid; Chromatography, High Pressure Liquid; Circadian Rhythm; Endothelium; Ganglia, Sympathetic; Ganglionectomy; Glutamates; Glutamic Acid; Glutamine; Immunohistochemistry; Male; Melatonin; Neuroglia; Pineal Gland; Rats; Rats, Sprague-Dawley; Serine; Taurine | 1992 |
Ethanol inhibits release of excitatory amino acids from slices of hippocampal area CA1.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Ethanol; Female; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Potassium; Rats; Rats, Sprague-Dawley | 1992 |
N-alkoxycarbonyl-glutamic and aspartic acids. Studies on the activation and cyclodehydration and side-reaction encountered in analysis of glutamic acid using Fmoc-chloride.
Topics: Amino Acids; Aspartic Acid; Ethyldimethylaminopropyl Carbodiimide; Fluorenes; Glutamates; Glutamic Acid; Methylene Chloride | 1992 |
Evaluation of the role of electrostatic residues in human epidermal growth factor by site-directed mutagenesis and chemical modification.
Topics: Amino Acid Sequence; Arginine; Aspartic Acid; Electrochemistry; Epidermal Growth Factor; ErbB Receptors; Glutamates; Glutamic Acid; Glutamine; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation | 1992 |
The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801.
Topics: Animals; Aspartic Acid; Culture Techniques; Deoxyglucose; Dizocilpine Maleate; Glucose; Glutamates; Glutamic Acid; Hippocampus; Histological Techniques; Hypoglycemia; N-Methylaspartate; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Time Factors | 1992 |
Kindling seizure induction and excitatory amino acid.
Topics: Animals; Aspartic Acid; Brain; Cats; Electric Stimulation; Epilepsy; Glutamates; Glutamic Acid; Kindling, Neurologic | 1992 |
Differential modulation of Purkinje cell activity by enkephalin and corticotropin releasing factor.
Topics: Action Potentials; Animals; Aspartic Acid; Corticotropin-Releasing Hormone; Enkephalins; Glutamates; Glutamic Acid; Iontophoresis; Opossums; Purkinje Cells; Second Messenger Systems | 1992 |
Nucleotide-iron-sulfur cluster signal transduction in the nitrogenase iron-protein: the role of Asp125.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aspartic Acid; Azotobacter vinelandii; Binding Sites; Crystallization; Electron Transport; Glutamates; Glutamic Acid; Iron-Sulfur Proteins; Molecular Structure; Mutagenesis, Site-Directed; Nitrogenase; Protein Conformation; Signal Transduction | 1992 |
Site-directed mutagenesis at aspartate and glutamate residues of xylanase from Bacillus pumilus.
Topics: Aspartic Acid; Bacillus; Base Sequence; Circular Dichroism; Computer Simulation; Glutamates; Glutamic Acid; Glycoside Hydrolases; Immunodiffusion; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Protein Structure, Secondary; Sequence Homology, Amino Acid; Xylan Endo-1,3-beta-Xylosidase | 1992 |
Identification of aspartic acid 514 through glutamic acid 542 as a glycoprotein Ib-IX complex receptor recognition sequence in von Willebrand factor. Mechanism of modulation of von Willebrand factor by ristocetin and botrocetin.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Crotalid Venoms; Glutamates; Glutamic Acid; Hemagglutinins; Iodine Radioisotopes; Molecular Sequence Data; Platelet Membrane Glycoproteins; Ristocetin; Spectrophotometry, Ultraviolet; von Willebrand Factor | 1992 |
Probing the active site of the reconstituted aspartate/glutamate carrier from mitochondria. Structure/function relationship involving one lysine and two cysteine residues.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4-Chloro-7-nitrobenzofurazan; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Aspartic Acid; Binding Sites; Cattle; Electrophoresis, Polyacrylamide Gel; Glutamates; Glutamic Acid; Mitochondria, Heart; Proteolipids; Structure-Activity Relationship | 1992 |
Reversal by 3,3',5-triido-L-thyronine of the working memory deficit, and the decrease in acetylcholine, glutamate and gamma-aminobutyric acid induced by ethylcholine aziridinium ion in mice.
Topics: Acetylcholine; Animals; Aspartic Acid; Aziridines; Behavior, Animal; Brain; Choline; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Hippocampus; Male; Memory; Memory Disorders; Mice; Mice, Inbred Strains; Neuromuscular Blocking Agents; Neurotransmitter Agents; Taurine; Triiodothyronine | 1992 |
Regional distribution of glutamate and aspartate in adult and old human brain.
Topics: Adult; Aged; Aged, 80 and over; Aging; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Rats | 1992 |
[Co-determination of taurine and other free amino acids in the brain during complex immunohistochemical study of the cat and rat somatosensory cortex].
Topics: Animals; Aspartic Acid; Brain; Cats; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Immunohistochemistry; Rats; Somatosensory Cortex; Taurine | 1992 |
In vivo identification and monitoring of changes in rat brain glucose by two-dimensional shift-correlated 1H NMR spectroscopy.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain; Glucose; Glutamates; Glutamic Acid; Glutamine; Hydrogen; Inositol; Magnetic Resonance Spectroscopy; Male; Monitoring, Physiologic; Rats; Rats, Wistar | 1992 |
Effect of introducing different carboxylate-containing side chains at position 85 on chromophore formation and proton transport in bacteriorhodopsin.
Topics: Amino Acid Sequence; Aspartic Acid; Bacteriorhodopsins; Cysteine; Glutamates; Glutamic Acid; Halobacterium salinarum; Iodoacetamide; Iodoacetates; Iodoacetic Acid; Kinetics; Mutagenesis, Site-Directed; Protons; Recombinant Proteins | 1992 |
Impaired tetramer assembly of variant medium-chain acyl-coenzyme A dehydrogenase with a glutamate or aspartate substitution for lysine 304 causing instability of the protein.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Alleles; Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Chromatography, Gel; Cloning, Molecular; Codon; Enzyme Stability; Genetic Variation; Glutamates; Glutamic Acid; Humans; Kinetics; Lysine; Macromolecular Substances; Mitochondria, Liver; Polymerase Chain Reaction; Protein Biosynthesis; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Transcription, Genetic | 1992 |
A highly potent and selective N-methyl-D-aspartate receptor antagonist from the venom of the Agelenopsis aperta spider.
Topics: Agatoxins; Animals; Aspartic Acid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neurotoxins; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spiders | 1992 |
An experimental arthritis in rats: dorsal horn aspartate and glutamate increases.
Topics: Animals; Arthritis, Experimental; Aspartic Acid; Carrageenan; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence | 1992 |
Increased plasma concentrations of aspartate, glutamate and glycine in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Female; Glutamates; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Parkinson Disease | 1992 |
3H-D-aspartate release from cerebellar granule neurons is differentially regulated by glutamate- and K(+)-stimulation.
Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Dantrolene; Glutamates; Glutamic Acid; Neurons; Nocodazole; Potassium; Rats; Rats, Wistar; Verapamil | 1992 |
Glutamine and glucose metabolism in bovine blood lymphocytes.
Topics: Adenosine Triphosphate; Ammonia; Animals; Aspartic Acid; Blood Glucose; Cattle; Glutamates; Glutamic Acid; Glutamine; Humans; In Vitro Techniques; Lactates; Lactic Acid; Lymphocytes; Male; Pyruvates; Pyruvic Acid; Rats | 1992 |
Measurement of glutamate, aspartate and glycine and its potential precursors in human brain using high-performance liquid chromatography by pre-column derivatization with dimethylaminoazobenzene [correction of diethylaminoazobenzene] sulphonyl chloride.
Topics: Aged; Aspartic Acid; Brain Chemistry; Chromatography, High Pressure Liquid; Female; Glutamates; Glutamic Acid; Glycine; Humans; Male; Middle Aged; p-Dimethylaminoazobenzene | 1992 |
Limbic seizure-induced changes in extracellular amino acid levels in the hippocampal formation: a microdialysis study of freely moving rats.
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Brain Mapping; Chromatography, High Pressure Liquid; Dialysis; Extracellular Space; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Kainic Acid; Limbic System; Male; Rats; Rats, Wistar; Seizures; Serine; Synaptic Transmission | 1992 |
Glutamate and aspartate are decreased in the skin in amyotrophic lateral sclerosis.
Topics: Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biopsy; Collagen; Female; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Reference Values; Skin | 1992 |
Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat.
Topics: Action Potentials; Animals; Animals, Newborn; Aspartic Acid; Brain Stem; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Locomotion; N-Methylaspartate; Nerve Net; Quisqualic Acid; Rats; Rats, Wistar; Serotonin; Spinal Cord | 1992 |
Chemical modification studies of the active centre of Candida albicans chitinase and its inhibition by allosamidin.
Topics: Acetylglucosamine; Aspartic Acid; Binding Sites; Binding, Competitive; Candida albicans; Chitinases; Diethyl Pyrocarbonate; Ethyldimethylaminopropyl Carbodiimide; Glutamates; Glutamic Acid; Kinetics; Phenylglyoxal; Sulfhydryl Reagents; Trisaccharides | 1992 |
Molecular requirements for hapten binding to antibodies against glutamate and aspartate.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Antigen-Antibody Reactions; Aspartic Acid; Cross Reactions; Dipeptides; Glutamates; Glutamic Acid; Glutaral; Haptens; Immunoenzyme Techniques; Models, Molecular; Molecular Sequence Data; Rabbits; Receptors, Amino Acid | 1992 |
Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo.
Topics: Amino Acids; Anesthetics; Animals; Aspartic Acid; Calcium; Cats; Caudate Nucleus; Female; Glutamates; Glutamic Acid; Male; Potassium; Riluzole; Thiazoles | 1992 |
A simple method for electrical field stimulation of cultured granule cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Neurons; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Temperature; Tetrodotoxin; Veratridine | 1992 |
Distribution of glutamate-like and glutamine-like immunoreactivities in the rat organ of Corti: a light microscopic and semiquantitative electron microscopic analysis with a note on the localization of aspartate.
Topics: Animals; Antibody Specificity; Aspartic Acid; Glutamates; Glutamic Acid; Glutamine; Immunohistochemistry; Male; Microscopy, Electron; Organ of Corti; Rats; Rats, Wistar | 1992 |
Changes in content of neuroactive amino acids and acetylcholine in the rat hippocampus following transient forebrain ischemia.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Hippocampus; Ischemic Attack, Transient; Male; Neurons; Neurotransmitter Agents; Prosencephalon; Pyramidal Tracts; Rats; Rats, Wistar; Reference Values; Taurine; Time Factors | 1992 |
X-ray structure of Glu 53 human lysozyme.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Glutamates; Glutamic Acid; Humans; Models, Molecular; Muramidase; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Secondary; Thermodynamics; X-Ray Diffraction | 1992 |
Ambruticin S production in amino acid rich media.
Topics: Amino Acids; Aspartic Acid; Bacteriological Techniques; Chromatography, High Pressure Liquid; Culture Media; Glutamates; Glutamic Acid; Industrial Microbiology; Myxococcales; Pyrans | 1990 |
N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. I. Location on axon terminals and pharmacological characterization.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Axons; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptosomes | 1992 |
Potentiation of NMDA receptor currents by arachidonic acid.
Topics: Animals; Arachidonic Acid; Aspartic Acid; Calcium; Cerebellum; Drug Synergism; Electric Conductivity; Glutamates; Glutamic Acid; Ion Channel Gating; Ion Channels; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems | 1992 |
Fast excitatory postsynaptic potentials and the responses to excitant amino acids of sympathetic preganglionic neurons in the slice of the cat spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Cats; Electric Stimulation; Evoked Potentials; Ganglia, Sympathetic; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Membrane Potentials; Neurons; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synapses | 1992 |
Excitatory amino acid receptors on isolated retinal ganglion cells from the goldfish.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cells, Cultured; Chlorides; Electrophysiology; Glutamates; Glutamic Acid; Goldfish; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Retinal Ganglion Cells; Sodium | 1992 |
Retrograde transport of D-[3H]-aspartate injected into the monkey amygdaloid complex.
Topics: Amygdala; Animals; Aspartic Acid; Cerebral Cortex; Frontal Lobe; Glutamates; Glutamic Acid; Hippocampus; Histocytochemistry; Horseradish Peroxidase; Injections; Macaca fascicularis; Male; Neurons, Afferent; Temporal Lobe; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1992 |
Serotonin-, substance P- and glutamate/aspartate-like immunoreactivities in medullo-spinal pathways of rat and primate.
Topics: Animals; Aspartic Acid; Colchicine; Glutamates; Glutamic Acid; Macaca fascicularis; Male; Medulla Oblongata; Motor Neurons; Neural Pathways; Neurons; Rats; Rats, Inbred Strains; Serotonin; Species Specificity; Spinal Cord; Substance P | 1992 |
Sources of presumptive glutamatergic/aspartatergic afferents to the mediodorsal nucleus of the thalamus in the rat.
Topics: Animals; Aspartic Acid; Brain Stem; Cerebral Cortex; Glutamates; Glutamic Acid; Horseradish Peroxidase; Hypothalamus; Neurons, Afferent; Prosencephalon; Rats; Thalamic Nuclei; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1992 |
Proportion of glutamate- and aspartate-immunoreactive neurons in the efferent pathways of the rat visual cortex varies according to the target.
Topics: Animals; Aspartic Acid; Axonal Transport; Efferent Pathways; Functional Laterality; Glutamates; Glutamic Acid; Horseradish Peroxidase; Immunohistochemistry; Neurons; Pons; Rats; Rats, Inbred Strains; Superior Colliculi; Visual Cortex; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1992 |
Effects of riluzole (2-amino-6-trifluoromethoxy benzothiazole) on striatal neurochemical markers in the rat, with special reference to the dopamine, choline, GABA and glutamate synaptosomal high affinity uptake systems.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Biomarkers; Choline; Corpus Striatum; Culture Media; Dopamine; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hydroxyindoleacetic Acid; Neurotransmitter Uptake Inhibitors; Rats; Rats, Wistar; Riluzole; Serotonin; Synaptic Transmission; Synaptosomes; Thiazoles; Tritium | 1992 |
Acetylcholine release from the rabbit retina mediated by kainate receptors.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Choline; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Rabbits; Receptors, Kainic Acid; Receptors, Neurotransmitter; Retina | 1991 |
Neurochemical characterization of excitotoxin lesions in the cerebral cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Homocysteine; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; NADPH Dehydrogenase; Neuropeptides; Neurotoxins; Neurotransmitter Agents; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
Release of endogenous and newly synthesized glutamate and of other amino acids induced by non-N-methyl-D-aspartate receptor activation in cerebellar granule cell cultures.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Exocytosis; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Potassium; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Taurine | 1991 |
Glutamine and glucose metabolism in rat splenocytes and mesenteric lymph node lymphocytes.
Topics: Adenosine Triphosphate; Ammonia; Animals; Aspartic Acid; Carbon Dioxide; Cells, Cultured; Glucose; Glutamates; Glutamic Acid; Glutamine; Lymph Nodes; Lymphocytes; Male; Rats; Rats, Inbred WF; Spleen | 1991 |
NGF and excitatory neurotransmitters regulate survival and morphogenesis of cultured cerebellar Purkinje cells.
Topics: Animals; Aspartic Acid; Axons; Cell Survival; Cells, Cultured; Glutamates; Glutamic Acid; Nerve Growth Factors; Neurotransmitter Agents; Potassium; Purkinje Cells; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Veratridine | 1991 |
Enhanced aspartate release from hippocampal slices of epileptic (El) mice.
Topics: Animals; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Potassium | 1991 |
D-2 dopamine receptors inhibit release of aspartate and glutamate in rat retina.
Topics: Animals; Aspartic Acid; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Potassium; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Retina; Sulpiride | 1991 |
Functional hepatocyte heterogeneity in glutamate, aspartate and alpha-ketoglutarate uptake: a histoautoradiographical study.
Topics: Animals; Aspartic Acid; Autoradiography; Biological Transport; Glutamates; Glutamic Acid; Hepatic Veins; Ketoglutaric Acids; Liver; Male; Perfusion; Portal Vein; Rats; Rats, Inbred Strains; Tissue Distribution; Tritium | 1991 |
Elevated glutamine metabolism in splenocytes from spontaneously diabetic BB rats.
Topics: Adenosine Triphosphate; Ammonia; Animals; Aspartic Acid; Carbon Radioisotopes; Cells, Cultured; Diabetes Mellitus, Experimental; Female; Glutamates; Glutamic Acid; Glutamine; Kinetics; Lactates; Lymphocytes; Male; Pyruvates; Rats; Rats, Inbred BB; Spleen | 1991 |
The mechanism of Ca2(+)-related control of gluconeogenesis in perfused liver.
Topics: Animals; Aspartic Acid; Biological Transport; Calcium; Glucagon; Gluconeogenesis; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Mitochondria, Liver; Oxidation-Reduction; Perfusion; Phenylephrine; Rats; Tetradecanoylphorbol Acetate | 1991 |
Autoreceptor regulation of glutamate and aspartate release from slices of the hippocampal CA1 area.
Topics: Animals; Aspartic Acid; Female; Glutamates; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Kainic Acid; Ligands; Magnesium; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, AMPA; Receptors, Cell Surface; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1991 |
Correlation of the extracellular glutamate concentration with extent of blood flow reduction after subdural hematoma in the rat.
Topics: Amino Acids; Animals; Aspartic Acid; Blood Flow Velocity; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Disease Models, Animal; Glutamates; Glutamic Acid; Glutamine; Hematoma, Subdural; Male; Rats; Rats, Inbred Strains; Regression Analysis; Valine | 1991 |
Evidence of glutamatergic deficiency in schizophrenia.
Topics: Aged; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Haloperidol; Humans; In Vitro Techniques; Male; Middle Aged; Schizophrenia; Synaptosomes; Veratridine | 1991 |
Reduction of infarct size by systemic amino acid supplementation during reperfusion.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hemodynamics; Myocardial Infarction; Myocardial Reperfusion Injury; Swine; Ventricular Function, Left | 1991 |
Glutamate dehydrogenase reaction as a source of glutamic acid in synaptosomes.
Topics: Amino Acids; Amino Acids, Cyclic; Ammonia; Animals; Aspartic Acid; Energy Metabolism; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Male; Rats; Rats, Inbred Strains; Synaptosomes; Veratridine | 1991 |
Displacement of endogenous glutamate with D-aspartate: an effective strategy for reducing the calcium-independent component of glutamate release from synaptosomes.
Topics: Animals; Aspartic Acid; Calcium; Glutamates; Glutamic Acid; Hippocampus; Kinetics; Male; Potassium; Rats; Rats, Inbred Strains; Synaptosomes | 1991 |
Excitatory and inhibitory amino acid changes in ischemic brain regions in spontaneously hypertensive rats.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Cerebral Cortex; Corpus Striatum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Hippocampus; Hypertension; Ischemic Attack, Transient; Male; Nucleus Accumbens; Rats; Rats, Inbred SHR; Septum Pellucidum; Taurine | 1991 |
Receptor types mediating the rise in the cytosolic free calcium concentration by L-aspartate and L-glutamate in immature cerebellar neurons with N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Calcium; Cerebellum; Cytosol; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kinetics; Magnesium; Neurons; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Products of non-reductive CO2 assimilation in the halophilic archaebacterium Haloferax mediterranei.
Topics: Alanine; Amino Acids; Ammonia; Archaea; Aspartic Acid; Bicarbonates; Carbon Dioxide; Glutamates; Glutamic Acid; Keto Acids; Propionates; Pyruvates; Pyruvic Acid; Sodium; Sodium Bicarbonate | 1991 |
Cortical ablation reduces veratridine evoked release of endogenous glutamate from superfused substantia nigra slices.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Nerve Endings; Neural Pathways; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Substantia Nigra; Veratridine | 1991 |
DL-threo-3-hydroxyaspartate reduces NMDA receptor activation by glutamate in cultured neurons.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Cyclic GMP; Glutamates; Glutamic Acid; Kainic Acid; Neurons; Rats; Receptors, N-Methyl-D-Aspartate | 1991 |
Electrogenic uptake of glutamate and aspartate into glial cells isolated from the salamander (Ambystoma) retina.
Topics: Ambystoma; Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Magnesium; Membrane Potentials; Neuroglia; Potassium; Retina; Sodium | 1991 |
Mesencephalic stimulation elicits inhibition of phrenic nerve activity in cat.
Topics: Animals; Aspartic Acid; Cats; Electric Stimulation; Female; Glutamates; Glutamic Acid; Male; Mesencephalon; Neural Inhibition; Phrenic Nerve; Respiration; Time Factors | 1991 |
Assignment of resonance in the 1H spectrum of rat brain by two-dimensional shift correlated and J-resolved NMR spectroscopy.
Topics: Alanine; Animals; Aspartic Acid; Brain Chemistry; Chromatography, Ion Exchange; Creatine; Electron Spin Resonance Spectroscopy; Female; Fourier Analysis; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Hydrogen; Inositol; Lactates; Magnetic Resonance Spectroscopy; Rats; Rats, Inbred Strains; Taurine; Threonine | 1991 |
Aspartate-like immunoreactivity in primary afferent neurons.
Topics: Afferent Pathways; Animals; Aspartic Acid; Ganglia, Spinal; Glutamates; Glutamic Acid; Nerve Endings; Neurons; Nociceptors; Rats; Rats, Inbred Strains | 1991 |
Glutamate and aspartate immunoreactivity in hypothalamic presynaptic axons.
Topics: Animals; Antibody Specificity; Aspartic Acid; Axons; Calcium; Enzyme-Linked Immunosorbent Assay; Fixatives; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hypothalamus; Immune Sera; Immunoblotting; Immunohistochemistry; N-Methylaspartate; Rats; Synapses | 1991 |
Tyrosine 70 fine-tunes the catalytic efficiency of aspartate aminotransferase.
Topics: Aspartate Aminotransferases; Aspartic Acid; Enzyme Inhibitors; Escherichia coli; Glutamates; Glutamic Acid; Isotopes; Ketoglutaric Acids; Kinetics; Maleates; Mutation; N-Methylaspartate; Spectrophotometry; Tyrosine | 1991 |
[The aspartate/NMDA-sensitizing effect of piracetam].
Topics: Allosteric Site; Animals; Aspartic Acid; Electric Conductivity; Glutamates; Glutamic Acid; Membrane Potentials; Microelectrodes; Motor Neurons; Piracetam; Rana esculenta; Receptors, N-Methyl-D-Aspartate | 1991 |
The effects of hypothermia on amino acid neurotransmitter release from the cerebral cortex.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Hypothermia, Induced; Male; Rats; Rats, Inbred Strains; Secretory Rate | 1991 |
On the mechanism of inhibition of gluconeogenesis and ureagenesis by sodium benzoate.
Topics: Acetyl Coenzyme A; Adenine Nucleotides; Animals; Aspartic Acid; Benzoates; Benzoic Acid; Bicarbonates; Carbamoyl-Phosphate Synthase (Ammonia); Cells, Cultured; Enzyme Activation; Gluconeogenesis; Glutamates; Glutamic Acid; Kinetics; Liver; Male; Mitochondria, Liver; Orotic Acid; Pyruvate Carboxylase; Rats; Sodium; Sodium Bicarbonate; Urea | 1991 |
Quantification of glutamate, glutamine, and other metabolites in in vivo proton NMR spectroscopy.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; Glutamine; Magnetic Resonance Spectroscopy; Protons; Rats | 1991 |
On the identification of cerebral metabolites in localized 1H NMR spectra of human brain in vivo.
Topics: Animals; Aspartic Acid; Brain; Choline; Creatine; Glucose; Glutamates; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Protons; Rats; Taurine | 1991 |
Activation of excitatory amino acid receptors cannot alone account for anoxia-induced impairment of protein synthesis in rat hippocampal slices.
Topics: Animals; Aspartic Acid; Carbon Radioisotopes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; Hypoxia; Kainic Acid; Lysine; Male; N-Methylaspartate; Nerve Tissue Proteins; Phenazocine; Phencyclidine; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1991 |
Regional heterogeneity of L-glutamate and L-aspartate high-affinity uptake systems in the rat CNS.
Topics: Animals; Aspartic Acid; Biological Transport; Central Nervous System; Cerebellum; Cerebral Cortex; Glutamates; Glutamic Acid; Hippocampus; Male; Rats; Rats, Inbred Strains; Tritium | 1991 |
Donor hearts with impaired hemodynamics. Benefit of warm substrate-enriched blood cardioplegic solution for induction of cardioplegia during cardiac harvesting.
Topics: Animals; Aspartic Acid; Blood; Brain Death; Cardioplegic Solutions; Cardiotonic Agents; Dogs; Glutamates; Glutamic Acid; Heart; Heart Arrest, Induced; Heart Transplantation; Hemodynamics; Myocardium; Tissue Donors | 1991 |
Receptor regulation of the glutamate, GABA and taurine high-affinity uptake into astrocytes in primary culture.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; Cerebral Cortex; Cholera Toxin; Colforsin; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Isoproterenol; Kinetics; Phenylephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin; Taurine; Virulence Factors, Bordetella | 1991 |
Cerebral glucose is detectable by localized proton NMR spectroscopy in normal rat brain in vivo.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain; Choline; Creatine; Glucose; Glutamates; Glutamic Acid; Inositol; Magnetic Resonance Spectroscopy; Phosphocreatine; Protons; Rats; Rats, Inbred Strains; Taurine | 1991 |
Changes in free amino acid concentrations in serum, brain, and CSF throughout embryogenesis.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Chick Embryo; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Microtubule-Associated Proteins; Optic Lobe, Nonmammalian; tau Proteins; Time Factors | 1991 |
Excitatory amino acids are released from rat primary afferent neurons in vitro.
Topics: Afferent Pathways; Animals; Animals, Newborn; Aspartic Acid; Capsaicin; Ganglia, Spinal; Glutamates; Glutamic Acid; Kinetics; Neurons; Neurotransmitter Agents; Organ Culture Techniques; Potassium; Rats | 1991 |
Ischemia does not induce the release of excitotoxic amino acids from the hippocampus of newborn rats.
Topics: Aging; Allopurinol; Animals; Animals, Newborn; Aspartic Acid; Brain Ischemia; Free Radicals; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; Rats; Rats, Inbred Strains | 1991 |
Nondestructive detection of glutamate by 1H nuclear magnetic resonance spectroscopy in cortical brain slices from the guinea pig: evidence for changes in detectability during severe anoxic insults.
Topics: Animals; Aspartic Acid; Brain; Chromatography, High Pressure Liquid; Creatinine; Energy Metabolism; Glutamates; Glutamic Acid; Guinea Pigs; Hydrogen-Ion Concentration; Hypoxia, Brain; In Vitro Techniques; Intracellular Membranes; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male | 1991 |
Excitatory amino acids in amyotrophic lateral sclerosis: an update.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Humans; Prospective Studies | 1991 |
The effects of surface charges on the redox potential of cytochrome c2 from the purple phototrophic bacterium Rhodobacter capsulatus.
Topics: Aspartic Acid; Cytochrome c Group; Cytochromes c2; Electrochemistry; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Isoelectric Point; Lysine; Mutagenesis; Osmolar Concentration; Oxidation-Reduction; Rhodobacter capsulatus | 1991 |
[Sequential changes in content of excitatory amino acids in the epileptic focus during seizure].
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Cats; Dialysis; Epilepsies, Partial; Extracellular Space; Glutamates; Glutamic Acid; Kindling, Neurologic; Seizures | 1991 |
Mg2+, Asp-, and Glu--effects in the processive and distributive DNA relaxation catalyzed by a eukaryotic topoisomerase.
Topics: Ammonia; Aspartic Acid; Candida; Catalysis; DNA Topoisomerases, Type I; DNA, Bacterial; Glutamates; Glutamic Acid; Kinetics; Magnesium; Nucleic Acid Conformation; Plasmids; Potassium; Sodium | 1991 |
Na(+)-dependent transport of anionic amino acids by preimplantation mouse blastocysts.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport; Blastocyst; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Mice; Sodium | 1991 |
An efficient enzyme immunoassay for glutamate using glutaraldehyde coupling of the hapten to microtiter plates.
Topics: Alanine; Aspartic Acid; Binding, Competitive; Cross Reactions; Glutamates; Glutamic Acid; Glutaral; Hydrogen-Ion Concentration; Immunoenzyme Techniques; Reproducibility of Results; Time Factors | 1991 |
Neuropharmacological analysis of synaptic transmission in the Lorenzinian ampulla of the skate Raja clavata.
Topics: Acetylcholine; Animals; Aspartic Acid; Catecholamines; Dopamine; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Neurons, Afferent; Neurotransmitter Agents; Serotonin; Skates, Fish; Synapses; Synaptic Transmission; Taurine | 1991 |
Age estimation by amino acid racemization in teeth--a comparison of aspartic acid with glutamic acid and alanine as indicators.
Topics: Age Determination by Teeth; Alanine; Aspartic Acid; Glutamates; Glutamic Acid; Humans; In Vitro Techniques; Indicators and Reagents; Methods | 1991 |
A site-specific anti-HLA-DP monoclonal antibody recognizes molecules bearing "DE" at positions 55 and 56 on the beta chain.
Topics: Antibodies, Monoclonal; Antibody Specificity; Aspartic Acid; Glutamates; Glutamic Acid; HLA-DP Antigens; Humans; Molecular Structure; Polymorphism, Genetic | 1991 |
Chemical modification locates guanidinyl and carboxylate groups within the active site of prolidase.
Topics: Amino Acid Sequence; Animals; Arginine; Aspartic Acid; Binding Sites; Carbodiimides; CME-Carbodiimide; Cross-Linking Reagents; Dipeptidases; Glutamates; Glutamic Acid; Kidney; Molecular Sequence Data; Phenylglyoxal; Structure-Activity Relationship; Swine | 1991 |
Stimulation of 22Na+ efflux from rat forebrain membrane vesicles by L-glutamic acid, L-aspartic acid and kainic acid.
Topics: Animals; Aspartic Acid; Cell Fractionation; Cell Membrane; Glutamates; Glutamic Acid; Kainic Acid; Male; Prosencephalon; Rats; Sodium; Temperature; Veratridine | 1991 |
Outflow of endogenous aspartate and glutamate from the rat spinal dorsal horn in vitro by activation of low- and high-threshold primary afferent fibers. Modulation by mu-opioids.
Topics: Afferent Pathways; Animals; Aspartic Acid; Capsaicin; Diterpenes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ganglia, Spinal; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Kinetics; Naloxone; Nerve Fibers; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Time Factors | 1991 |
Depolarization-evoked release of glutamate, aspartate and gamma-aminobutyric acid from rat dorsal spinal cord slices does not originate from capsaicin-sensitive neurons.
Topics: Animals; Aspartic Acid; Capsaicin; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Immunohistochemistry; Neuromuscular Depolarizing Agents; Neurons; Potassium; Rats; Rats, Inbred Strains; Spinal Cord; Tetrodotoxin; Veratridine | 1991 |
The potassium-dependence of excitatory amino acid transport: resolution of a paradox.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Neuroglia; Potassium; Retina; Urodela | 1991 |
Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS.
Topics: Amino Acids; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cerebral Cortex; Dipeptides; Glutamates; Glutamic Acid; Humans; Motor Cortex; Reference Values; Spinal Cord | 1991 |
Complete functional recovery after 24-hour heart preservation with University of Wisconsin solution and modified reperfusion.
Topics: Adenosine; Allopurinol; Animals; Animals, Newborn; Aspartic Acid; Blood; Cardioplegic Solutions; Cold Temperature; Glutamates; Glutamic Acid; Glutathione; Heart; Insulin; Leukapheresis; Myocardial Reperfusion; Myocardial Reperfusion Injury; Organ Preservation; Organ Preservation Solutions; Raffinose; Solutions; Swine; Time Factors | 1991 |
Coupling effects in volume selective 1H spectroscopy of major brain metabolites.
Topics: Aspartic Acid; Brain Chemistry; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Humans; Inositol; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy | 1991 |
Physiological interactions between enkephalin and excitatory amino acids in the cerebellar cortex of the opossum Didelphis marsupialis virginiana.
Topics: Animals; Aspartic Acid; Cerebellar Cortex; Drug Interactions; Electrophysiology; Enkephalins; Female; Glutamates; Glutamic Acid; Iontophoresis; Male; Naloxone; Opossums; Purkinje Cells | 1991 |
Neurotransmitter amino acid levels in rat thalamus and cerebral cortex after cerebellectomy.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebellum; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Reference Values; Thalamus; Time Factors | 1991 |
Use of high performance liquid chromatography in defining the abnormalities in the free amino acid patterns in the cerebrospinal fluid of patients with aseptic meningitis.
Topics: Adult; Aged; Amino Acids; Aspartic Acid; Chromatography, High Pressure Liquid; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Humans; Male; Meningitis, Aseptic; Middle Aged; Phenylalanine; Tyrosine | 1991 |
Platelet glycine, glutamate and aspartate in primary headache.
Topics: Aspartic Acid; Blood Platelets; Cluster Headache; Glutamates; Glutamic Acid; Glycine; Headache; Humans; Migraine Disorders; Reference Values | 1991 |
Conversion of citrate synthase into citryl-CoA lyase as a result of mutation of the active-site aspartic acid residue to glutamic acid.
Topics: Acetyl Coenzyme A; Aspartic Acid; Base Sequence; Binding Sites; Catalysis; Citrate (si)-Synthase; DNA; Escherichia coli; Glutamates; Glutamic Acid; Lyases; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation | 1991 |
Glutamate-immunoreactivity in the trigeminal and dorsal root ganglia, and intraspinal neurons and fibres in the dorsal horn of the rat.
Topics: Animals; Aspartic Acid; Autoradiography; Fluorescent Antibody Technique; Ganglia, Spinal; Glutamates; Glutamic Acid; Immunoenzyme Techniques; Immunohistochemistry; Neurons; Rats; Rats, Inbred Strains; Spinal Cord; Trigeminal Ganglion | 1991 |
Hyperammonemic alterations in the uptake and release of glutamate and aspartate by rat cerebellar preparations.
Topics: Ammonia; Animals; Aspartic Acid; Astrocytes; Cerebellum; Glutamates; Glutamic Acid; Kinetics; Membrane Fluidity; Nerve Tissue Proteins; Neurons; Potassium Chloride; Rats; Rats, Inbred Strains; Synaptosomes | 1991 |
Effect of cyclocreatine feeding on levels of amino acids in rat hearts before and after an ischemic episode.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Aspartic Acid; Coronary Disease; Creatinine; Diet; Energy Metabolism; Female; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Magnetic Resonance Spectroscopy; Male; Myocardial Reperfusion; Myocardium; Phosphates; Rats; Rats, Inbred Strains | 1991 |
Receptor sub-types involved in responses of Purkinje cell to exogenous excitatory amino acids and local electrical stimulation in cerebellar slices in the rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Amino Acids; Animals; Aspartic Acid; Bicuculline; Cerebellum; Electric Stimulation; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Purkinje Cells; Quinoxalines; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1991 |
Sequential changes in content of excitatory amino acids in the focus of epilepsy in seizure induction.
Topics: Amygdala; Animals; Aspartic Acid; Cats; Chromatography, High Pressure Liquid; Electroencephalography; Epilepsy; Evoked Potentials; Glutamates; Glutamic Acid; Kindling, Neurologic; Seizures | 1991 |
Excitatory amino acids evoke taurine release from cerebral cortex slices from adult and developing mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dipeptides; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotoxins; Potassium; Quisqualic Acid; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Secretory Rate; Stimulation, Chemical; Taurine | 1991 |
Bacillus subtilis cytochrome oxidase mutants: biochemical analysis and genetic evidence for two aa3-type oxidases.
Topics: Aspartic Acid; Bacillus subtilis; Blotting, Southern; Chromosome Deletion; Cytochrome c Group; Cytochrome d Group; Cytochromes; Drug Resistance, Microbial; Electron Transport Complex IV; Escherichia coli; Glucose; Glutamates; Glutamic Acid; Mutation; Phleomycins; Plasmids; Spectrophotometry; Tetramethylphenylenediamine | 1991 |
Structural characterization of human alveolar bone proteoglycans.
Topics: Alveolar Process; Aspartic Acid; Bone Matrix; Chondroitin Sulfates; Chromatography, Ion Exchange; Electrophoresis, Cellulose Acetate; Electrophoresis, Polyacrylamide Gel; Fourier Analysis; Glutamates; Glutamic Acid; Glycine; Glycosaminoglycans; Hexosamines; Hexoses; Humans; Leucine; Molecular Weight; Proteoglycans; Sodium Dodecyl Sulfate; Spectrophotometry, Infrared; Uronic Acids | 1991 |
Saccular afferents to second-order cochlear neurons. An horseradish peroxidase and immunocytochemical study.
Topics: Afferent Pathways; Animals; Aspartic Acid; Cochlea; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Horseradish Peroxidase; Immunohistochemistry; Male; Neurons, Afferent; Saccule and Utricle | 1991 |
A novel selective NMDA agonist, N-phthalamoyl-L-glutamic acid (PhGA).
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hippocampus; Magnesium; N-Methylaspartate; Neurons; Osmolar Concentration | 1991 |
Actions of (-)-baclofen on rat dorsal horn neurons.
Topics: Action Potentials; Animals; Aspartic Acid; Baclofen; Calcium; Glutamates; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Neurons; Rats; Rats, Inbred Strains; Sodium; Spinal Cord; Synapses; Synaptic Transmission | 1991 |
The pharmacological profile of glutamate-evoked ascorbic acid efflux measured by in vivo electrochemistry.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Ascorbic Acid; Aspartic Acid; Brain; Corpus Striatum; Electric Stimulation; Electrochemistry; Globus Pallidus; Glutamates; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; Microinjections; N-Methylaspartate; Organ Specificity; Potentiometry; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Thalamus | 1991 |
K(+)-stimulated amino acid release from cultured cerebellar neurons: comparison of static and dynamic stimulation paradigms.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kinetics; Magnesium; Microscopy, Electron; Models, Neurological; Neurons; Potassium; Rats | 1991 |
Brain amino acid reductions in one family with chromosome 6p-linked dominantly inherited olivopontocerebellar atrophy.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Aspartic Acid; Brain Chemistry; Chromosomes, Human, Pair 6; Ethanolamines; gamma-Aminobutyric Acid; Genes, Dominant; Glutamates; Glutamic Acid; Glutamine; Humans; Middle Aged; Olivopontocerebellar Atrophies; Taurine | 1991 |
Differences in transmitter release, morphology, and ischemia-induced cell injury between cerebellar granule cell cultures developing in the presence and in the absence of a depolarizing potassium concentration.
Topics: Animals; Aspartic Acid; Brain Ischemia; Calcium; Cell Count; Cell Hypoxia; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Immunochemistry; Membrane Potentials; Mice; Microscopy, Electron; Neurons; Potassium; Synaptophysin | 1991 |
[4-Tesla 1H MR spectroscopy in patients with temporal lobe epilepsy].
Topics: Adolescent; Adult; Aspartic Acid; Choline; Creatine; Energy Metabolism; Epilepsies, Partial; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Glutamates; Glutamic Acid; Humans; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phosphocreatine; Phosphorylcholine; Reference Values; Temporal Lobe | 1991 |
Quinolinic acid is a potent lipid peroxidant in rat brain homogenates.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Kynurenine; Lipid Peroxidation; Male; Malondialdehyde; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Thiobarbiturates | 1991 |
Regulatory effect of neurotransmitter by hemofiltration in cardiogenic shock patients after open heart surgery.
Topics: Adolescent; Adult; Aged; Ammonia; Aspartic Acid; Brain Edema; Coronary Artery Bypass; Female; Glasgow Coma Scale; Glutamates; Glutamic Acid; Glycine; Hemofiltration; Hepatic Encephalopathy; Humans; Male; Middle Aged; Postoperative Care; Shock, Cardiogenic | 1991 |
Non-opioid antitussives inhibit endogenous glutamate release from rabbit hippocampal slices.
Topics: Animals; Antitussive Agents; Aspartic Acid; Cyclopentanes; Depression, Chemical; Dextromethorphan; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Male; Potassium; Rabbits | 1991 |
Sensitivity of rubrospinal neurons to excitatory amino acids in the rat red nucleus in vivo.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Aspartic Acid; Cats; Cerebellum; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Iontophoresis; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Red Nucleus; Species Specificity | 1991 |
Histidine regulation of cyclic AMP metabolism in cultured renal epithelial LLC-PK1 cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Arginine Vasopressin; Aspartic Acid; Cells, Cultured; Colforsin; Cyclic AMP; Epithelial Cells; Epithelium; Glutamates; Glutamic Acid; Histidine; Imidazoles; Indomethacin; Kidney; Swine | 1990 |
The effects of substance P and calcitonin gene-related peptide on the efflux of endogenous glutamate and aspartate from the rat spinal dorsal horn in vitro.
Topics: Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Capsaicin; Glutamates; Glutamic Acid; In Vitro Techniques; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1990 |
Biodegradation of copoly(L-aspartic acid/L-glutamic acid) in vitro.
Topics: Aspartic Acid; Biodegradation, Environmental; Chemical Phenomena; Chemistry, Physical; Dipeptides; Glutamic Acid; Kinetics; Molecular Weight; Papain; Peptides; Polyglutamic Acid; Viscosity | 1990 |
Tachykinins and calcitonin gene-related peptide enhance release of endogenous glutamate and aspartate from the rat spinal dorsal horn slice.
Topics: Amino Acids; Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Neurokinin A; Rats; Rats, Inbred Strains; Recombinant Proteins; Spinal Cord; Spinal Nerve Roots; Substance P | 1990 |
Striatal preprotachykinin and preproenkephalin mRNA levels and the levels of nigral substance P and pallidal Met5-enkephalin depend on corticostriatal axons that use the excitatory amino acid neurotransmitters aspartate and glutamate: quantitative radioim
Topics: Animals; Aspartic Acid; Axons; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Enkephalins; Gene Expression Regulation; Globus Pallidus; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Male; Methionine Sulfoximine; Neurotransmitter Agents; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Substance P; Substantia Nigra; Synaptic Transmission; Tachykinins | 1990 |
Pore-like and carrier-like properties of the mitochondrial aspartate/glutamate carrier after modification by SH-reagents: evidence for a performed channel as a structural requirement of carrier-mediated transport.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Cattle; Glutamates; Glutamic Acid; Ion Channels; Sulfhydryl Reagents | 1990 |
Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord.
Topics: Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Interactions; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Pain; Pain Measurement; Quisqualic Acid; Rats; Rats, Inbred Strains; Reaction Time; Self Mutilation; Spinal Cord; Substance P; Taurine | 1990 |
Relationship of glutamate and aspartate to the periaqueductal gray-raphe magnus projection: analysis using immunocytochemistry and microdialysis.
Topics: Animals; Aspartic Acid; Axonal Transport; Dialysis; Glutamates; Glutamic Acid; Horseradish Peroxidase; Immunohistochemistry; Male; Microscopy, Electron; Neural Pathways; Neurons; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Inbred Strains; Wheat Germ Agglutinins | 1990 |
Ultrastructural visualization of glutamate and aspartate immunoreactivities in the rat dorsal horn, with special reference to the co-localization of glutamate, substance P and calcitonin-gene related peptide.
Topics: Amino Acids; Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Immunohistochemistry; Male; Membrane Proteins; Nerve Tissue Proteins; Neuropeptides; Rats; Rats, Inbred Strains; Spinal Cord; Staining and Labeling; Substance P; Synaptophysin; Tissue Distribution | 1991 |
Extracellular alkaline-acid pH shifts evoked by iontophoresis of glutamate and aspartate in turtle cerebellum.
Topics: Animals; Aspartic Acid; Bicarbonates; Cadmium; Calcium Channel Blockers; Cerebellum; Electric Stimulation; Extracellular Space; Female; Glutamates; Glutamic Acid; HEPES; Hydrogen-Ion Concentration; Ion Channel Gating; Ion Channels; Iontophoresis; Male; Manganese; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Turtles | 1991 |
Asp383 in the second transmembrane domain of the lutropin receptor is important for high affinity hormone binding and cAMP production.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cattle; Cricetinae; Cyclic AMP; DNA; Female; Glutamates; Glutamic Acid; Humans; Luteinizing Hormone; Molecular Sequence Data; Mutagenesis; Rats; Receptors, LH; RNA; Sequence Homology, Nucleic Acid | 1991 |
Characterization of glutamate uptake systems in astrocyte primary cultures from rat brain.
Topics: Animals; Asparagine; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; Chlorides; Glutamates; Glutamic Acid; Ion Channels; Kinetics; Potassium; Quisqualic Acid; Rats; Sodium | 1991 |
Disposition of amino acid synaptic transmitters, acetylcholine and substance P in the LM-suprageniculate nuclear complex of the cat's thalamus.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Aspartic Acid; Cats; Choline O-Acetyltransferase; Geniculate Bodies; Glutamates; Glutamic Acid; Immunohistochemistry; Neurotransmitter Agents; Substance P; Synapses; Thalamus | 1991 |
Excitatory amino acid immunoreactivity in vestibulo-ocular neurons in gerbils.
Topics: Animals; Aspartic Acid; Auditory Pathways; Axonal Transport; Gerbillinae; Glutamates; Glutamic Acid; Histocytochemistry; Horseradish Peroxidase; Neurons; Neurotransmitter Agents; Visual Pathways | 1991 |
Role of excitatory amino acid receptors in K+- and glutamate-evoked release of endogenous adenosine from rat cortical slices.
Topics: Adenosine; Animals; Aspartic Acid; Calcium; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Potassium; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1990 |
Glutamine and aspartate loading of synaptosomes: a reevaluation of effects on calcium-dependent excitatory amino acid release.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Glutamates; Glutamic Acid; Glutamine; Guinea Pigs; Synaptosomes | 1990 |
[3H]N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine ([3H]TCP) binding in human frontal cortex: decreases in Alzheimer-type dementia.
Topics: Alzheimer Disease; Aspartic Acid; Binding Sites; Frontal Lobe; Glutamates; Glutamic Acid; Humans; Membranes; N-Methylaspartate; Phencyclidine; Reference Values | 1990 |
NMDA receptors mediate poly- and monosynaptic potentials in motoneurons of rat embryos.
Topics: Animals; Aspartic Acid; Electrophysiology; Glutamates; Glutamic Acid; Kainic Acid; Motor Neurons; N-Methylaspartate; Neurons, Afferent; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Nerve Roots; Synapses; Synaptic Transmission | 1990 |
Searching sequence space by definably random mutagenesis: improving the catalytic potency of an enzyme.
Topics: Aspartic Acid; Carbohydrate Epimerases; Escherichia coli; Genes, Bacterial; Glutamates; Glutamic Acid; Kinetics; Models, Molecular; Mutation; Oligonucleotide Probes; Plasmids; Protein Conformation; Triose-Phosphate Isomerase | 1990 |
Protonation state of Asp (Glu)-85 regulates the purple-to-blue transition in bacteriorhodopsin mutants Arg-82----Ala and Asp-85----Glu: the blue form is inactive in proton translocation.
Topics: Alanine; Arginine; Aspartic Acid; Bacteriorhodopsins; Glutamates; Glutamic Acid; Halobacterium; Kinetics; Mutation; Protons; Spectrophotometry | 1990 |
N-methyl-D-aspartate recognition site ligands modulate activity at the coupled glycine recognition site.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Glutamates; Glutamic Acid; Glycine; Ligands; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines | 1990 |
Effects of hypoxia-ischemia and MK-801 treatment on the binding of a phencyclidine analogue in the developing rat brain.
Topics: Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hypoxia; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Tritium | 1990 |
High resolution 13C-solid state NMR of bacteriorhodopsin: assignment of specific aspartic acids and structural implications of single site mutations.
Topics: Aspartic Acid; Bacteriorhodopsins; Carbon Isotopes; Glutamates; Glutamic Acid; Glycine; Halobacterium; Magnetic Resonance Spectroscopy; Mutation; Tryptophan | 1990 |
Inhibitory effect of glutamic acid and aspartic acid on calcium oxalate crystal formation.
Topics: Aspartic Acid; Calcium Oxalate; Crystallization; Glutamates; Glutamic Acid; Humans; Microscopy, Electron, Scanning; Urinary Calculi | 1990 |
Stimulation of synaptosomal gamma-aminobutyric acid synthesis by glutamate and glutamine.
Topics: 4-Aminobutyrate Transaminase; Animals; Aspartic Acid; Culture Media; Cyclohexanecarboxylic Acids; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Glutamine; Male; Osmolar Concentration; Rats; Rats, Inbred Strains; Synaptosomes | 1990 |
Brain amino acid concentration changes during status epilepticus induced by lithium and pilocarpine.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Electroencephalography; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Lithium; Male; Pilocarpine; Rats; Rats, Inbred Strains; Status Epilepticus; Tissue Distribution | 1990 |
Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Free Radicals; Glutamates; Glutamic Acid; Male; Neurons; Oxygen; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Xanthine; Xanthine Oxidase; Xanthines | 1990 |
Effect of climbing fiber deprivation on release of endogenous aspartate, glutamate, and homocysteate in slices of rat cerebellar hemispheres and vermis.
Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Nerve Fibers; Potassium; Pyridines; Rats | 1990 |
Postnatal development of the excitatory amino acid system in visual cortex of the rat. Changes in uptake and levels of aspartate and glutamate.
Topics: Aging; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Male; Rats; Rats, Inbred Strains; Visual Cortex | 1990 |
Catalytic mechanism of fungal glucoamylase as defined by mutagenesis of Asp176, Glu179 and Glu180 in the enzyme from Aspergillus awamori.
Topics: Amino Acid Sequence; Aspartic Acid; Aspergillus; Base Sequence; Binding Sites; Catalysis; DNA Restriction Enzymes; Glucan 1,4-alpha-Glucosidase; Glucans; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Isomaltose; Kinetics; Maltose; Molecular Sequence Data; Mutation; Sequence Homology, Nucleic Acid; Structure-Activity Relationship; Thermodynamics | 1990 |
Depletion of the Ca(++)-dependent releasable pool of glutamate in striatal synaptosomes associated with dendrotoxin-induced potassium channel blockade.
Topics: Animals; Aspartic Acid; Calcium; Corpus Striatum; Elapid Venoms; Glutamates; Glutamic Acid; Male; Potassium Channels; Rats; Synaptosomes | 1990 |
Spermine stabilization of folded ribonuclease T1.
Topics: Aspartic Acid; Endoribonucleases; Enzyme Stability; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Ligands; Magnesium; Protein Binding; Protein Conformation; Ribonuclease T1; Spectrophotometry, Ultraviolet; Spermine; Thermodynamics | 1990 |
Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures.
Topics: Amino Acids; Animals; Anions; Aspartic Acid; Astrocytes; Biological Transport; Cell Survival; Cells, Cultured; Culture Media; Cytochalasin B; Glutamates; Glutamic Acid; Hypotonic Solutions; Sodium; Taurine | 1990 |
Hepatic encephalopathy influences high-affinity uptake of transmitter glutamate and aspartate into the hippocampal formation.
Topics: Adult; Aged; Aged, 80 and over; Ammonia; Animals; Aspartic Acid; Female; Glutamates; Glutamic Acid; Hepatic Encephalopathy; Hippocampus; Humans; Liver Cirrhosis; Male; Middle Aged; Neurotransmitter Agents; Rats; Rats, Inbred Strains | 1990 |
GABA, glycine, aspartate, glutamate and taurine in the vestibular nuclei: an immunocytochemical investigation in the cat.
Topics: Amino Acids; Animals; Aspartic Acid; Cats; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Immunohistochemistry; Neurotransmitter Agents; Taurine; Vestibular Nuclei | 1990 |
High-performance liquid chromatographic determination of selected amino acids in rat brain by precolumn derivatization with phenylisothiocyanate.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Isothiocyanates; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Serine; Thiocyanates | 1990 |
Synthesis of valproyl-2-pyrrolidinone and its evaluation as a cognitive drug with the ability to modulate acidic amino acids in the brain.
Topics: Administration, Oral; Animals; Aspartic Acid; Behavior, Animal; Brain; Cognition; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Male; Pantothenic Acid; Pyrrolidinones; Rats; Rats, Inbred Strains | 1990 |
Cloning and sequencing of a gene encoding a glutamate and aspartate carrier of Escherichia coli K-12.
Topics: Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA, Bacterial; Escherichia coli; Genes, Bacterial; Glutamates; Glutamic Acid; Molecular Sequence Data | 1990 |
Induction of locomotion in spinal tadpoles by excitatory amino acids and their agonists.
Topics: Animals; Anura; Aspartic Acid; Glutamates; Glutamic Acid; Kainic Acid; Locomotion; Motor Activity; N-Methylaspartate; Spinal Cord; Swimming | 1990 |
Adenosinergic approaches to stroke therapeutics.
Topics: Adenosine; Aspartic Acid; Cerebrovascular Disorders; Glutamates; Glutamic Acid; Humans; Receptors, Purinergic | 1990 |
Fine distribution of gamma-aminobutyric acid, aspartate and glutamate in human dentate nucleus.
Topics: Aged; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Humans; Male; Middle Aged; Neurotransmitter Agents | 1990 |
Synthesis of beta- and gamma-fluorenylmethyl esters of respectively N alpha-Boc-L-aspartic acid and N alpha-Boc-L-glutamic acid.
Topics: Aspartic Acid; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Esterification; Fluorenes; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Molecular Structure; Spectrophotometry, Infrared | 1990 |
Flow-injection analysis of amino acids and their metabolites by immobilized vitamin B6-dependent enzymes. Sensitive determination of L-aspartate, L-glutamate, 2-oxoglutarate, and oxaloacetate.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Cattle; Enzymes, Immobilized; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Ketoglutaric Acids; Luminescent Measurements; Malate Dehydrogenase; NAD; Oxaloacetates; Pyridoxine | 1990 |
Glutamate and glycine induce a negative wave on hippocampal field response through NMDA receptors.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glycine; Hippocampus; Male; N-Methylaspartate; Neural Inhibition; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Substitution of aspartic acid-217 of Citrobacter freundii cephalosporinase and properties of the mutant enzymes.
Topics: Aspartic Acid; beta-Lactamases; Cephalosporinase; Citrobacter; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Bacterial; Glutamates; Glutamic Acid; Kinetics; Lysine; Mutation; Substrate Specificity; Threonine | 1990 |
Acute- and long-term glutamate-mediated regulation of [Ca++]i in rat hippocampal pyramidal neurons in vitro.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Long-term potentiation in the rat hippocampus induced by the mast cell degranulating peptide: analysis of the release of endogenous excitatory amino acids and proteins.
Topics: Action Potentials; Adaptation, Biological; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hippocampus; Male; Molecular Weight; Nerve Tissue Proteins; Neurotransmitter Agents; Peptides; Rats; Rats, Inbred Strains | 1990 |
Differential expression of excitatory amino acid receptor subtypes in cultured cerebellar neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Kinetics; N-Methylaspartate; Neurons; Oxadiazoles; Potassium Chloride; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Effects of hypoxia on release of amino acid neurotransmitters from fetal lamb brain in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Culture Techniques; Female; Glutamates; Glutamic Acid; Glycine; Hippocampus; Hypoxia, Brain; Maternal-Fetal Exchange; Neurotransmitter Agents; Pregnancy; Sheep | 1990 |
Glutamate uptake in mammalian retinal glia is voltage- and potassium-dependent.
Topics: Animals; Aspartic Acid; Carrier Proteins; Glutamates; Glutamic Acid; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neuroglia; Neurotransmitter Agents; Potassium; Rabbits; Retina | 1990 |
Acetylcholine potentiates responses to N-methyl-D-aspartate in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Action Potentials; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Selective loss of N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain following portacaval anastomosis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ammonia; Animals; Aspartic Acid; Brain; Cerebral Cortex; Corpus Striatum; Down-Regulation; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Kainic Acid; Liver; Male; N-Methylaspartate; Organ Size; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Thalamus | 1990 |
Structural consequences of the replacement of Glu239 by Gln in the catalytic chain of Escherichia coli aspartate transcarbamylase.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamyl Phosphate; Cytidine Triphosphate; Escherichia coli; Glutamates; Glutamic Acid; Glutamine; Phosphonoacetic Acid; Protein Engineering; Structure-Activity Relationship; X-Ray Diffraction | 1990 |
Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis.
Topics: Acetylcholine; Aging; Animals; Aspartic Acid; Calcium; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hearing Loss, Sensorineural; Inferior Colliculi; Neurons; Potassium; Presbycusis; Rats; Rats, Inbred F344 | 1990 |
Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Kinetics; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Valine | 1990 |
Pseudomonas aeruginosa exotoxin A: alterations of biological and biochemical properties resulting from mutation of glutamic acid 553 to aspartic acid.
Topics: ADP Ribose Transferases; Affinity Labels; Animals; Aspartic Acid; Bacterial Toxins; Clone Cells; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Exotoxins; Genes, Bacterial; Glutamates; Glutamic Acid; Kinetics; Mutation; Poly(ADP-ribose) Polymerases; Pseudomonas aeruginosa; Pseudomonas aeruginosa Exotoxin A; Rats; Thermolysin; Virulence Factors | 1990 |
The kinetic mechanism of wild-type and mutant mouse dihydrofolate reductases.
Topics: Animals; Aspartic Acid; Binding Sites; Escherichia coli; Folic Acid; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Mice; Mutation; Tetrahydrofolate Dehydrogenase | 1990 |
In vivo release of endogenous glutamate and aspartate in the rat striatum during stimulation of the cortex.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Deuterium; Electric Stimulation; Glutamates; Glutamic Acid; Kinetics; Leucine; Male; Rats; Rats, Inbred Strains | 1990 |
Distribution of N-acetylaspartate, N-acetylaspartylglutamate, free glutamate and aspartate following complete mesencephalic transection in rat neuraxis.
Topics: Animals; Aspartic Acid; Brain Chemistry; Brain Stem; Cerebellum; Dipeptides; Glutamates; Glutamic Acid; Male; Mesencephalon; Rats; Rats, Inbred Strains; Reference Values; Spinal Cord | 1990 |
A site-directed mutagenesis study on Escherichia coli inorganic pyrophosphatase. Glutamic acid-98 and lysine-104 are important for structural integrity, whereas aspartic acids-97 and -102 are essential for catalytic activity.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Binding Sites; DNA, Bacterial; Escherichia coli; Glutamates; Glutamic Acid; Hot Temperature; Inorganic Pyrophosphatase; Lysine; Molecular Sequence Data; Mutation; Pyrophosphatases; Solubility; Structure-Activity Relationship | 1990 |
Ca2(+)-evoked [3H]dopamine release from synaptosomes is dependent on neuronal type Ca2+ channels and is not mediated by acetylcholine, glutamate or aspartate release.
Topics: Acetylcholine; Animals; Aspartic Acid; Atropine; Brain; Calcium; Calcium Channels; Cobalt; Culture Techniques; Dopamine; Drug Interactions; Ganglionic Blockers; Glutamates; Glutamic Acid; Hexamethonium; Hexamethonium Compounds; Nifedipine; Rats; Synaptosomes; Verapamil | 1990 |
An electrophysiological study of the action of N-methyl-D-aspartate on excitatory synaptic transmission in the optic tectum of the frog in vitro.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electrophysiology; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Rana temporaria; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Superior Colliculi; Synapses; Synaptic Transmission | 1990 |
Release of glutamate and aspartate from the visual cortex of the cat following activation of afferent pathways.
Topics: Animals; Aspartic Acid; Cats; Electric Stimulation; Female; gamma-Aminobutyric Acid; Geniculate Bodies; Glutamates; Glutamic Acid; Male; Neurotransmitter Agents; Photic Stimulation; Tetrodotoxin; Visual Cortex; Visual Pathways | 1990 |
Masking effect of NMDA receptor antagonists on the formation of long-term potentiation (LTP) in superior colliculus slices from the guinea pig.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Denervation; Dibenzocycloheptenes; Dipeptides; Dizocilpine Maleate; Evoked Potentials; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; Magnesium; Mice; Nerve Degeneration; Optic Nerve; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Superior Colliculi; Visual Cortex | 1990 |
Improved quantification of in vivo 1H NMR spectra by optimization of signal acquisition and processing and by incorporation of prior knowledge into the spectral fitting.
Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Cerebral Cortex; Glutamates; Glutamic Acid; Glutamine; Hydrogen; Image Enhancement; Ischemia; Liver; Magnetic Resonance Spectroscopy; Rats | 1990 |
Regulation of glutamate and aspartate release from the Schaffer collaterals and other projections of CA3 hippocampal pyramidal cells.
Topics: Adenosine; Animals; Aspartic Acid; Energy Metabolism; Female; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Neurotransmitter Agents; Potassium; Rats; Rats, Inbred Strains | 1990 |
Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Arachidonic Acid; Arachidonic Acids; Aspartic Acid; Cells, Cultured; Corpus Striatum; Cycloleucine; Electrophysiology; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1990 |
Amino acid neurotransmitter alterations in three sublines of Rb mice differing by their susceptibility to audiogenic seizures.
Topics: Acoustic Stimulation; Amino Acids; Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Male; Mice; Mice, Mutant Strains; Neurotransmitter Agents; Seizures; Taurine; Temporal Lobe; Tissue Distribution | 1990 |
In vivo evidence for an inhibitory glutamatergic control of serotonin release in the cat caudate nucleus: involvement of GABA neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Bicuculline; Cats; Caudate Nucleus; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurons; Riluzole; Serotonin; Spinal Cord; Synaptic Transmission; Tetrodotoxin; Thiazoles | 1990 |
Site-directed mutagenesis of rat liver S-adenosylhomocysteinase. Effect of conversion of aspartic acid 244 to glutamic acid on coenzyme binding.
Topics: Adenosylhomocysteinase; Apoenzymes; Aspartic Acid; Base Sequence; Binding Sites; Cloning, Molecular; Escherichia coli; Glutamates; Glutamic Acid; Hydrolases; Kinetics; Liver; Molecular Sequence Data; Molecular Weight; Mutation; NAD; Oligonucleotide Probes; Recombinant Proteins | 1990 |
Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex.
Topics: Allosteric Site; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Hippocampus; Ileum; Isometric Contraction; Kinetics; Male; Muscle, Smooth; N-Methylaspartate; Neurons; Norepinephrine; Pyrrolidinones; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes | 1990 |
Renal arginine synthesis: studies in vitro and in vivo.
Topics: Alanine; Ammonium Chloride; Animals; Arginine; Aspartic Acid; Citrulline; Glomerular Filtration Rate; Glutamates; Glutamic Acid; Glutamine; Glycine; In Vitro Techniques; Kidney Cortex; Kidney Tubules; Kinetics; Male; Rats; Rats, Inbred Strains; Serine | 1990 |
Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Ketamine; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Temperature; Time Factors | 1990 |
Periplasmic metabolism of glutamate and aspartate by intact Bradyrhizobium japonicum bacteroids.
Topics: Anaerobiosis; Aspartate Aminotransferases; Aspartic Acid; Biological Transport; Carbon Radioisotopes; Cytoplasm; Glutamates; Glutamic Acid; Malates; Models, Biological; Phosphoric Diester Hydrolases; Rhizobiaceae | 1990 |
Effect of aspartame on N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain synaptic membranes.
Topics: Animals; Aspartame; Aspartic Acid; Brain; Dipeptides; Glutamates; Glutamic Acid; Kinetics; Male; N-Methylaspartate; Phenylalanine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1990 |
Neuroexcitatory plasma amino acids are elevated in migraine.
Topics: Adult; Aging; Aspartic Acid; Female; Glutamates; Glutamic Acid; Headache; Humans; Male; Middle Aged; Migraine Disorders; Muscle Contraction; Osmolar Concentration; Time Factors | 1990 |
The mitochondrial aspartate/glutamate and ADP/ATP carrier switch from obligate counterexchange to unidirectional transport after modification by SH-reagents.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aspartic Acid; Bacterial Outer Membrane Proteins; Biological Transport; Calcium; Carrier Proteins; Cattle; Glutamates; Glutamic Acid; In Vitro Techniques; Liposomes; Mitochondria; Porins; Sulfhydryl Reagents | 1990 |
Purification, cloning, and tissue distribution of a 23-kDa rat protein isolated by morphine affinity chromatography.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Brain Chemistry; Chromatography, Affinity; Chromatography, High Pressure Liquid; Cloning, Molecular; DNA; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Liver; Male; Molecular Sequence Data; Molecular Weight; Morphine Derivatives; Nerve Tissue Proteins; Oligonucleotide Probes; Protein Conformation; Rats; Rats, Inbred Strains; Tissue Distribution; Tumor Cells, Cultured | 1990 |
Chronic methionine sulfoximine administration reduces synaptosomal aspartate and glutamate in rat striatum.
Topics: Animals; Aspartic Acid; Brain; Corpus Striatum; Enzyme Inhibitors; Glutamates; Glutamic Acid; Male; Methionine Sulfoximine; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Synaptosomes | 1990 |
Excitatory amino acid pathways in brain-stimulation reward.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Mapping; Dominance, Cerebral; Glutamates; Glutamic Acid; Male; Medial Forebrain Bundle; Motivation; Nerve Fibers; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Self Stimulation; Synaptic Transmission; Tegmentum Mesencephali | 1990 |
Rapid, sensitive, and simple method for quantification of both neurotoxic and neurotrophic effects of NMDA on cultured cerebellar granule cells.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; Culture Media; Dizocilpine Maleate; Glutamates; Glutamic Acid; Mice; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Potassium | 1990 |
[Relations of glutamate and aspartate contents of the heart and its energy state after ischemia].
Topics: Animals; Aspartic Acid; Coronary Disease; Energy Metabolism; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Myocardial Reperfusion; Myocardium | 1990 |
Aspartate-like and glutamate-like immunoreactivities in the inferior olive and climbing fibre system: a light microscopic and semiquantitative electron microscopic study in rat and baboon (Papio anubis).
Topics: Afferent Pathways; Animals; Antibody Specificity; Aspartic Acid; Glutamates; Glutamic Acid; Immunologic Techniques; Microscopy, Electron; Nerve Fibers; Neurons; Olivary Nucleus; Papio; Rats; Rats, Inbred Strains | 1990 |
Excitatory amino acid kindling in rats.
Topics: Amygdala; Animals; Aspartic Acid; Electroencephalography; Evoked Potentials; Glutamates; Glutamic Acid; Kindling, Neurologic; Rats; Receptors, N-Methyl-D-Aspartate | 1990 |
Glutamate- and aspartate-induced extracellular potassium and calcium shifts and their relation to those of kainate, quisqualate and N-methyl-D-aspartate in the isolated turtle cerebellum.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cerebellum; Dose-Response Relationship, Drug; Extracellular Space; Glutamates; Glutamic Acid; In Vitro Techniques; Iontophoresis; Kainic Acid; Manganese; N-Methylaspartate; Potassium; Quisqualic Acid; Turtles | 1990 |
Autoradiographic characterization of putative excitatory amino acid transport sites.
Topics: Amino Acids; Animals; Aspartic Acid; Autoradiography; Binding Sites; Biological Transport; Brain; Chlorides; Glutamates; Glutamic Acid; Male; Rats; Rats, Inbred Strains; Sodium; Tissue Distribution | 1990 |
Active-site mutations of diphtheria toxin: effects of replacing glutamic acid-148 with aspartic acid, glutamine, or serine.
Topics: Adenosine Diphosphate Ribose; Affinity Labels; Aspartic Acid; Base Sequence; Binding Sites; Diphtheria Toxin; Glutamates; Glutamic Acid; Glutamine; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Peptide Elongation Factor 2; Peptide Elongation Factors; Serine; Substrate Specificity | 1990 |
Determinants of visual pigment absorbance: identification of the retinylidene Schiff's base counterion in bovine rhodopsin.
Topics: Animals; Asparagine; Aspartic Acid; Cattle; Glutamates; Glutamic Acid; Glutamine; Kinetics; Membranes; Models, Molecular; Mutagenesis, Site-Directed; Plasmids; Protein Conformation; Recombinant Proteins; Retinaldehyde; Rhodopsin; Schiff Bases; Spectrophotometry | 1990 |
Increased aspartic acid release from the iron-induced epileptogenic focus.
Topics: Acute Disease; Animals; Aspartic Acid; Chronic Disease; Epilepsy; Glutamates; Glutamic Acid; Iron; Male; Rats; Rats, Inbred Strains | 1990 |
Changes in [K+]0 at the vitreal surface compared with those around receptors in the isolated rabbit retina.
Topics: Animals; Aspartic Acid; Dark Adaptation; Electroretinography; Glutamates; Glutamic Acid; Light; Neurons; Photoreceptor Cells; Potassium; Rabbits; Retina; Vitreous Body | 1990 |
Aspartic acid release from cerebral cortical slices of E1 mice with high seizure susceptibility.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Mice; Mice, Mutant Strains; Potassium; Seizures | 1990 |
Actions of excitatory amino acids on brisk ganglion cells in the cat retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Anesthesia; Animals; Aspartic Acid; Cats; Electrodes; Glutamates; Glutamic Acid; Ibotenic Acid; Iontophoresis; Kainic Acid; N-Methylaspartate; Photic Stimulation; Quisqualic Acid; Retinal Ganglion Cells | 1990 |
Excitatory amino acid involvement in retinal degeneration.
Topics: Animals; Aspartic Acid; Blindness; Chickens; Crosses, Genetic; Female; Glutamates; Glutamic Acid; Male; Mutation; Reference Values; Retina; Retinal Degeneration | 1990 |
The non-competitive NMDA-receptor antagonist MK-801 prevents the massive release of glutamate and aspartate from rat striatum induced by 1-methyl-4-phenylpyridinium (MPP+).
Topics: 1-Methyl-4-phenylpyridinium; Animals; Aspartic Acid; Corpus Striatum; Dizocilpine Maleate; Dopamine; Glutamates; Glutamic Acid; Kinetics; Male; Rats; Rats, Inbred Strains | 1990 |
Relaxed specificity of endoproteinase Asp-N: this enzyme cleaves at peptide bonds N-terminal to glutamate as well as aspartate and cysteic acid residues.
Topics: Amino Acid Sequence; Amino Acids; Apolipoprotein A-I; Apolipoproteins A; Aspartic Acid; Chromatography, High Pressure Liquid; Cysteic Acid; Endopeptidases; Glutamates; Glutamic Acid; Humans; Metalloendopeptidases; Molecular Sequence Data; Peptide Fragments; Substrate Specificity | 1990 |
Amino acids as modulators of cholinergic nerves in airways.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Bronchi; Bronchoconstriction; Dose-Response Relationship, Drug; Electric Stimulation; Glutamates; Glutamic Acid; In Vitro Techniques; Muscle, Smooth; Osmolar Concentration; Parasympathetic Nervous System; Rats | 1990 |
Sources of presumptive glutamatergic/aspartatergic afferents to the magnocellular basal forebrain in the rat.
Topics: Afferent Pathways; Animals; Aspartic Acid; Brain Stem; Female; Globus Pallidus; Glutamates; Glutamic Acid; Horseradish Peroxidase; Limbic System; Male; Rats; Septum Pellucidum; Wheat Germ Agglutinins | 1990 |
Aspartyl- and glutamyl-lysine crosslinks formation and their nutritional availability.
Topics: Animals; Aspartic Acid; Biological Availability; Cross-Linking Reagents; Digestion; Dipeptidases; gamma-Glutamylcyclotransferase; Gliadin; Glutamates; Glutamic Acid; Intestinal Absorption; Kidney; Lysine; Nutritive Value; Peptide Hydrolases; Rats; Transglutaminases; Triticum | 1990 |
A microiontophoretic study of the role of excitatory amino acids at the afferent synapses of mammalian inner hair cells.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory, Inner; Iontophoresis; Male; Neurons, Afferent; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1990 |
Time-sequential change of amino acid neurotransmitters--GABA, aspartate and glutamate--in the rat basal ganglia following middle cerebral artery occlusion.
Topics: Animals; Aspartic Acid; Basal Ganglia; Brain Ischemia; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Male; Rats; Rats, Inbred Strains; Substantia Nigra | 1990 |
Evidence for clonidine presynaptically modulating amino acid release in the rostral ventral medulla: role in hypertension.
Topics: Amino Acids; Animals; Aspartic Acid; Clonidine; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hypertension; In Vitro Techniques; Medulla Oblongata; Neurotransmitter Agents; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Synapses; Synaptic Transmission; Synaptosomes; Yohimbine | 1990 |
Neuromodulatory effects of corticotropin releasing factor on cerebellar Purkinje cells: an in vivo study in the cat.
Topics: Action Potentials; Animals; Aspartic Acid; Cats; Corticotropin-Releasing Hormone; Drug Interactions; Electric Stimulation; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Purkinje Cells | 1990 |
Hb Hekinan observed in three Chinese from Macau; identification of the GAG----GAT mutation in the alpha 1-globin gene.
Topics: Adult; Amino Acid Sequence; Amino Acids; Aspartic Acid; Base Sequence; China; Codon; Female; Globins; Glutamates; Glutamic Acid; Hemoglobins, Abnormal; Humans; Macau; Molecular Sequence Data; Mutation | 1990 |
Isolation and characterization of 15K noncollagenous protein from bovine periodontal ligament.
Topics: Alanine; Animals; Aspartic Acid; Cattle; Chromatography, Gel; Enzyme-Linked Immunosorbent Assay; Glutamates; Glutamic Acid; Leucine; Lysine; Periodontal Ligament; Protein Biosynthesis; Proteins; Radioimmunoassay | 1990 |
[Studies on pyruvate kinase from pig dental pulp and brain].
Topics: Animals; Aspartic Acid; Brain; Dental Pulp; Electrophoresis, Polyacrylamide Gel; Glutamates; Glutamic Acid; Glycolysis; Malates; Molecular Weight; Oxalates; Pyruvate Kinase; Swine | 1990 |
[Age estimation by amino acid racemization in teeth. A comparison of data for aspartic acid, glutamic acid and alanine].
Topics: Age Determination by Teeth; Alanine; Amino Acids; Aspartic Acid; Glutamates; Glutamic Acid; Humans; Molecular Structure; Stereoisomerism | 1990 |
A comparison of the effects of serotonin, substance P and thyrotropin-releasing hormone on excitability of rat spinal motoneurons in vivo.
Topics: Animals; Anterior Horn Cells; Aspartic Acid; Drug Synergism; Glutamates; Glutamic Acid; Male; Motor Neurons; Rats; Rats, Inbred Strains; Serotonin; Substance P; Thyrotropin-Releasing Hormone | 1985 |
Correlation between cytochrome oxidase staining and the uptake and laminar distribution of tritiated aspartate, glutamate, gamma-aminobutyrate and glycine in the striate cortex of the squirrel monkey.
Topics: Amino Acids; Animals; Aspartic Acid; Autoradiography; Brain Chemistry; Electron Transport Complex IV; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Injections, Intraventricular; Male; Neurons; Saimiri; Staining and Labeling; Visual Cortex | 1985 |
Progressive supranuclear palsy: relationship between extrapyramidal disturbances, dementia, and brain neurotransmitter markers.
Topics: Aged; Aspartic Acid; Basal Ganglia Diseases; Brain; Bulbar Palsy, Progressive; Choline O-Acetyltransferase; Dementia; Dopamine; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Neurons; Neurotransmitter Agents; Norepinephrine; Parkinson Disease, Secondary; Serotonin | 1985 |
Isolation and properties of sea turtle (Chelonia mydas) pituitary prolactin.
Topics: Amino Acids; Animals; Aspartic Acid; Disulfides; Electrophoresis, Polyacrylamide Gel; Epitopes; Glutamates; Glutamic Acid; Humans; Leucine; Pituitary Gland; Prolactin; Radioimmunoassay; Serine; Species Specificity; Turtles | 1985 |
Cobalt ions block L-glutamate and L-aspartate-induced currents in cultured neurons from embryonic chick spinal cord.
Topics: Animals; Aspartic Acid; Cell Membrane Permeability; Cells, Cultured; Chick Embryo; Cobalt; Embryo, Mammalian; Embryo, Nonmammalian; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ion Channels; Membrane Potentials; Spinal Cord | 1985 |
Evidence that excitatory amino acids not only activate the receptor channel complex but also lead to use-dependent block.
Topics: Amino Acids; Animals; Aspartic Acid; Chick Embryo; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Neurotransmitter; Spinal Cord | 1986 |
Selective uptake of neuroactive amino acids by both oligodendrocytes and astrocytes in primary dissociated culture: a possible role for oligodendrocytes in neurotransmitter metabolism.
Topics: Alanine; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Autoradiography; Brain; Cells, Cultured; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Mice; Neuroglia; Neurotransmitter Agents; Oligodendroglia; Staining and Labeling; Taurine | 1986 |
Spectra of neurotransmitter receptors and ionic responses on cerebral A and B neurons in Aplysia californica.
Topics: Acetylcholine; Animals; Aplysia; Aspartic Acid; Dopamine; gamma-Aminobutyric Acid; Ganglia; Glutamates; Glutamic Acid; Histamine; In Vitro Techniques; Ion Channels; Neurotransmitter Agents; Serotonin | 1986 |
Substance P and calcitonin gene-related peptide synergistically modulate the gain of the nociceptive flexor withdrawal reflex in the rat.
Topics: Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Synergism; Glutamates; Glutamic Acid; Injections, Spinal; Leg; Motor Neurons; Muscles; Nerve Tissue Proteins; Nociceptors; Physical Stimulation; Rats; Reflex; Substance P; Toes | 1986 |
Phencyclidine selectively blocks a spinal action of N-methyl-D-aspartate in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Norepinephrine; Oxadiazoles; Phencyclidine; Quisqualic Acid; Spinal Cord; Substance P; Tetrazoles; Valine | 1986 |
Inhibition by K+ of Na+-dependent D-aspartate uptake into brain membrane saccules.
Topics: Animals; Aspartic Acid; Binding, Competitive; Biological Transport; Brain; Cations, Monovalent; Cell Membrane; Cesium; Glutamates; Glutamic Acid; Gramicidin; Potassium; Quaternary Ammonium Compounds; Rats; Rubidium; Sodium; Synaptic Membranes | 1986 |
Glutamate and aspartate activated channels and inhibitory synaptic currents in large cerebellar neurons grown in culture.
Topics: Animals; Aspartic Acid; Cerebellum; Culture Techniques; Glutamates; Glutamic Acid; Ion Channels; Membrane Potentials; Neural Inhibition; Rats; Synaptic Membranes | 1987 |
D-Arg1, D-Trp7,9, Leu11-substance P (spantide) does not antagonize substance P-induced hyperexcitability of the nociceptive flexion withdrawal reflex in the rat.
Topics: Afferent Pathways; Animals; Aspartic Acid; Evoked Potentials; Glutamates; Glutamic Acid; Injections, Spinal; Naloxone; Nociceptors; Physical Stimulation; Rats; Rats, Inbred Strains; Reflex; Spinal Cord; Substance P | 1987 |
Evidence for a magnesium-insensitive membrane resistance increase during NMDA-induced depolarizations in rat neocortical neurons in vitro.
Topics: Animals; Aspartic Acid; Cell Membrane; Electric Conductivity; Frontal Lobe; Glutamates; Glutamic Acid; Ion Channels; Magnesium; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1987 |
A study of amino acid-activated currents recorded from frog motoneurones in vitro.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anterior Horn Cells; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Ion Channels; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neural Conduction; Oxadiazoles; Quisqualic Acid; Rana temporaria; Valine | 1987 |
Relationships among ATP synthesis, K+ gradients, and neurotransmitter amino acid levels in isolated rat brain synaptosomes.
Topics: Adenosine Triphosphate; Amobarbital; Animals; Aspartic Acid; Brain; Energy Metabolism; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Ion Channels; Male; Neurotransmitter Agents; Oxygen Consumption; Potassium; Rats; Rats, Inbred Strains; Sodium; Synaptosomes | 1987 |
Use-dependent block of excitatory amino acid currents in cultured neurons by ketamine.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Electric Conductivity; Glutamates; Glutamic Acid; Hippocampus; Ion Channels; Kainic Acid; Ketamine; Membrane Potentials; Mice; N-Methylaspartate; Spinal Cord | 1987 |
Possible neurotransmitters of the dorsal column afferents: effects of dorsal column transection in the cat.
Topics: Animals; Aspartic Acid; Cats; Choline; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Medulla Oblongata; Neurons, Afferent; Neurotransmitter Agents; Spinal Cord; Substance P | 1987 |
NMDA receptors trigger excitement.
Topics: Aspartic Acid; Brain; Brain Ischemia; Cell Survival; Cerebrovascular Disorders; Electrophysiology; Glutamates; Glutamic Acid; Glycine; Heart Diseases; Humans; Ion Channels; Learning; Memory; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1988 |
Sustained dendritic gradients of Ca2+ induced by excitatory amino acids in CA1 hippocampal neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Benzofurans; Calcium; Dendrites; Fluorescent Dyes; Fura-2; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Ion Channels; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Potassium; Protein Kinase C; Sphingosine; Tetrodotoxin | 1988 |
Rapid activation and desensitization by glutamate of excitatory, cation-selective channels in locust muscle.
Topics: Animals; Aspartic Acid; Cations; Glutamates; Glutamic Acid; Grasshoppers; In Vitro Techniques; Ion Channels; Membrane Potentials; Muscles; Oxadiazoles; Quisqualic Acid | 1988 |
On the kinetics of large-conductance glutamate-receptor ion channels in rat cerebellar granule neurons.
Topics: Animals; Aspartic Acid; Cerebellum; Glutamates; Glutamic Acid; Ion Channels; Membrane Potentials; N-Methylaspartate; Neural Conduction; Neurons; Organ Culture Techniques; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1988 |
Behavior induced by putative nociceptive neurotransmitters is inhibited by adenosine or adenosine analogs coadministered intrathecally.
Topics: Adenosine; Animals; Aspartic Acid; Behavior, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Spinal; Male; Mice; N-Methylaspartate; Neurotransmitter Agents; Pain; Substance P | 1988 |
Noise and single channels activated by excitatory amino acids in rat cerebellar granule neurones.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1988 |
Multiple conductance channels in type-2 cerebellar astrocytes activated by excitatory amino acids.
Topics: Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebellum; Convulsants; Electric Conductivity; Evoked Potentials; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Synaptic Transmission | 1989 |
Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Synergism; Electric Conductivity; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Neuropeptides; Oxadiazoles; Peptides; Quisqualic Acid; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1989 |
Glutamate and aspartate immunoreactivity in corticospinal neurons of rats.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Horseradish Peroxidase; Immunohistochemistry; Pyramidal Tracts; Rats; Rats, Inbred Strains; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1989 |
Release of endogenous excitatory amino acids from turtle photoreceptors.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Electric Stimulation; Glutamates; Glutamic Acid; Hippocampus; Ion Channels; Lanthanum; Membrane Potentials; N-Methylaspartate; Neurons; Photoreceptor Cells; Receptors, Nicotinic; Turtles | 1989 |
Cloning by functional expression of a member of the glutamate receptor family.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Brain Chemistry; Cloning, Molecular; DNA; Electrophysiology; Gene Expression; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Molecular Sequence Data; Molecular Weight; N-Methylaspartate; Oocytes; Plasmids; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA; Tissue Distribution; Transcription, Genetic; Transfection; Xenopus | 1989 |
Immunocytochemical localization of glutamate immunoreactivity in the guinea pig cochlea.
Topics: Animals; Aspartic Acid; Cochlea; Fixatives; Glutamates; Glutamic Acid; Glutaral; Guinea Pigs; Hair Cells, Auditory; Immunohistochemistry; Staining and Labeling | 1989 |
Expression of excitatory amino acid receptors by cerebellar cells of the type-2 astrocyte cell lineage.
Topics: Animals; Aspartic Acid; Astrocytes; Autoradiography; Cell Line; Cerebellum; Drug Interactions; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Site-directed mutagenesis of the catalytic residues Asp-52 and Glu-35 of chicken egg white lysozyme.
Topics: Animals; Aspartic Acid; Base Sequence; Binding Sites; Chickens; Cloning, Molecular; Egg White; Glutamates; Glutamic Acid; Models, Molecular; Molecular Sequence Data; Muramidase; Mutation; Plasmids; Protein Conformation; Recombinant Proteins | 1989 |
Effects of buried ionizable amino acids on the reduction potential of recombinant myoglobin.
Topics: Asparagine; Aspartic Acid; Glutamates; Glutamic Acid; Heme; Humans; Mutation; Myoglobin; Oxidation-Reduction; Protein Conformation; Recombinant Proteins; Thermodynamics; Valine | 1989 |
L-[3H]glutamate binding to a membrane preparation from crayfish muscle.
Topics: Animals; Aspartic Acid; Astacoidea; Binding, Competitive; Calcium; Cell Membrane; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Muscles; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Stereoisomerism | 1989 |
Modulation of dendritic release of dopamine by N-methyl-D-aspartate receptors in rat substantia nigra.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Dendrites; Dopamine; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Kinetics; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Substantia Nigra; Tetrodotoxin | 1989 |
Postnatal development of glutamatergic, GABAergic, and cholinergic neurotransmitter phenotypes in the visual cortex, lateral geniculate nucleus, pulvinar, and superior colliculus in cats.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cats; Dark Adaptation; gamma-Aminobutyric Acid; Geniculate Bodies; Glutamates; Glutamic Acid; Neurotransmitter Agents; Parasympathomimetics; Phenotype; Superior Colliculi; Visual Cortex; Visual Pathways | 1989 |
Stereotypic morphology of glutamatergic synapses on identified muscle cells of Drosophila larvae.
Topics: Animals; Antibody Specificity; Aspartic Acid; Central Nervous System; Drosophila melanogaster; Glutamates; Glutamic Acid; Immunohistochemistry; Iontophoresis; Larva; Muscles; Neuromuscular Junction; Neurons; Neurotransmitter Agents; Synapses | 1989 |
Characterization of L-glutamate action on the release of endogenous dopamine from the rat caudate-putamen.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Caudate Nucleus; Dopamine; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Oxadiazoles; Phenazocine; Potassium; Putamen; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Platelet levels of glutamate and aspartate in normal subjects.
Topics: Adult; Aspartic Acid; Blood Platelets; Female; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Reference Values | 1989 |
Long-term potentiation in the hippocampus of the anaesthetized rat is not associated with a sustained enhanced release of endogenous excitatory amino acids.
Topics: Anesthesia, General; Animals; Aspartic Acid; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Characterization of excitatory amino acid receptors in cultured chick cerebellar neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Chick Embryo; Electric Conductivity; Glutamates; Glutamic Acid; Magnesium; Neurons; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Preliminary purification and characterization studies of a low molecular weight, high affinity cytosolic lead-binding protein in rat brain.
Topics: Animals; Aspartic Acid; Blotting, Western; Brain Chemistry; Carrier Proteins; Chromatography, Gel; Chromatography, Ion Exchange; Cysteine; Cytosol; Electrophoresis, Polyacrylamide Gel; Glutamates; Glutamic Acid; Lead; Liver; Male; Molecular Weight; Rabbits; Rats; Rats, Inbred Strains | 1989 |
[Arg292----Val] or [Arg292----Leu] mutation enhances the reactivity of Escherichia coli aspartate aminotransferase with aromatic amino acids.
Topics: Amino Acid Sequence; Arginine; Aspartate Aminotransferases; Aspartic Acid; Catalysis; Circular Dichroism; Cloning, Molecular; Escherichia coli; Glutamates; Glutamic Acid; Kinetics; Leucine; Mutation; Protein Conformation; Spectrophotometry; Structure-Activity Relationship; Substrate Specificity; Valine | 1989 |
Glutamate and aspartate immunoreactivity in cortico-cortical neurons of the sensorimotor cortex of rats.
Topics: Amidines; Animals; Aspartic Acid; Cell Count; Fluorescent Dyes; Glutamates; Glutamic Acid; Immunohistochemistry; Neural Pathways; Rats; Rats, Inbred Strains; Somatosensory Cortex | 1989 |
Effect of pyrithiamine treatment and subsequent thiamine rehabilitation on regional cerebral amino acids and thiamine-dependent enzymes.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Diseases; Glutamates; Glutamic Acid; Ketoglutarate Dehydrogenase Complex; Ketone Oxidoreductases; Male; Pyridinium Compounds; Pyrithiamine; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred Strains; Thiamine; Thiamine Deficiency | 1989 |
A spider toxin (JSTX) inhibits L-glutamate uptake by rat brain synaptosomes.
Topics: Animals; Arthropod Venoms; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Male; Phenylacetates; Rats; Rats, Inbred Strains; Spider Venoms; Synaptosomes | 1989 |
Pharmacological characterization of voltage-clamped catfish rod horizontal cell responses to kainic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Catfishes; Convulsants; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Photoreceptor Cells; Quisqualic Acid | 1989 |
Effects of a spider toxin (JSTX) on hippocampal CA1 neurons in vitro.
Topics: Action Potentials; Amino Acids; Animals; Arthropod Venoms; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; N-Methylaspartate; Receptors, Amino Acid; Receptors, Cell Surface; Spider Venoms; Time Factors | 1989 |
Excitatory amino acid-evoked release of [3H]GABA from hippocampal neurons in primary culture.
Topics: Animals; Aspartic Acid; Cells, Cultured; Ethers; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Ionomycin; Kainic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Veratridine; Zinc | 1989 |
Changes in excitatory amino acid receptor binding in the intact and decorticated rat neostriatum following insulin-induced hypoglycemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Caudate Nucleus; Cerebral Cortex; Corpus Striatum; Frontal Lobe; Glutamates; Glutamic Acid; Hypoglycemia; Ibotenic Acid; Insulin; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Solubilization of quisqualate-sensitive [3H]glutamate binding activity from rat retina.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cell Membrane; Glutamates; Glutamic Acid; Kinetics; Male; N-Methylaspartate; Octoxynol; Oxadiazoles; Polyethylene Glycols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Solubility | 1989 |
Effect of impact trauma on neurotransmitter and nonneurotransmitter amino acids in rat spinal cord.
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Kinetics; Laminectomy; Male; N-Methylaspartate; Neurotransmitter Agents; Rats; Serine; Spinal Cord; Spinal Cord Injuries; Taurine; Threonine | 1989 |
Regulation of Ca++ influx into striatal neurons by kainic acid.
Topics: Animals; Aspartic Acid; Calcium; Calcium Channels; Corpus Striatum; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Potassium; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium | 1989 |
Contamination of commercially available quisqualic acid by glutamate-like and aspartate-like substances.
Topics: Aspartic Acid; Chromatography, High Pressure Liquid; Drug Contamination; Glutamates; Glutamic Acid; Oxadiazoles; Quisqualic Acid | 1989 |
Study of amino acid formation during palmitate oxidation in rat brain mitochondria.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Ketoglutaric Acids; Mitochondria; Oxidation-Reduction; Palmitates; Palmitic Acids; Rats; Rats, Inbred Strains; Subcellular Fractions | 1989 |
K+ differentially affects the excitatory amino acids- and carbachol-elicited inositol phosphate formation in rat brain synaptoneurosomes.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Carbachol; Frontal Lobe; Glutamates; Glutamic Acid; Inositol Phosphates; N-Methylaspartate; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Sugar Phosphates; Synaptosomes | 1989 |
Utilization of amino acids and peptides by Fusobacterium nucleatum.
Topics: Amino Acids; Aspartic Acid; Culture Media; Fusobacterium; Glutamates; Glutamic Acid; Histidine; Lysine; Methionine; Peptides | 1989 |
Auditory nerve neurotransmitter acts on a kainate receptor: evidence from intracellular recordings in brain slices from mice.
Topics: Action Potentials; Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Mice; Mice, Inbred CBA; N-Methylaspartate; Receptors, Glutamate; Receptors, Neurotransmitter; Vestibulocochlear Nerve | 1989 |
Evidence that glutamate mediates axon-to-Schwann cell signaling in the squid.
Topics: Action Potentials; Animals; Aspartic Acid; Axons; Cell Communication; Convulsants; Decapodiformes; Electric Stimulation; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Oxadiazoles; Quisqualic Acid; Schwann Cells | 1989 |
Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia.
Topics: Aspartic Acid; Dopamine; Frontal Lobe; Glutamates; Glutamic Acid; Humans; Schizophrenia; Temporal Lobe | 1989 |
Effects of stretching and disuse on amino acids in muscles of rat hind limbs.
Topics: Amino Acids; Ammonia; Animals; Aspartic Acid; Denervation; Female; Glutamates; Glutamic Acid; Glutamine; Hindlimb; Immobilization; Muscle Contraction; Muscles; Rats; Rats, Inbred Strains; Tyrosine | 1989 |
Effect of repeated ingestion of aspartame-sweetened beverage on plasma amino acid, blood methanol, and blood formate concentrations in normal adults.
Topics: Adult; Amino Acids; Asparagine; Aspartame; Aspartic Acid; Beverages; Dipeptides; Female; Formates; Glutamates; Glutamic Acid; Glutamine; Humans; Male; Methanol; Phenylalanine; Tryptophan; Tyrosine | 1989 |
NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons.
Topics: Animals; Animals, Newborn; Anticonvulsants; Aspartic Acid; Cells, Cultured; Culture Media; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
The role of excitatory amino acids and NMDA receptors in traumatic brain injury.
Topics: Animals; Aspartic Acid; Binding, Competitive; Brain; Brain Injuries; Dextrorphan; Glutamates; Glutamic Acid; Magnesium; Magnetic Resonance Spectroscopy; Male; N-Methylaspartate; Phosphates; Phosphocreatine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
N-methyl-D-aspartate-sensitive [3H]glutamate binding sites in brain synaptic membranes treated with Triton X-100.
Topics: Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Brain; Glutamates; Glutamic Acid; Kinetics; Kynurenic Acid; N-Methylaspartate; Octoxynol; Polyethylene Glycols; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes; Temperature; Tissue Distribution | 1989 |
Excitatory amino acids enhance dissociation of zinc from soluble protein in cytosol of rat hippocampus.
Topics: Amino Acids; Animals; Aspartic Acid; Cytosol; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nerve Tissue Proteins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Zinc | 1989 |
A combination of intracellular leucine with either glutamate or aspartate inhibits autophagic proteolysis in isolated rat hepatocytes.
Topics: Amino Acids; Animals; Aspartic Acid; Enzyme Activation; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Intracellular Membranes; Leucine; Liver; Male; Peptide Hydrolases; Rats; Rats, Inbred Strains | 1989 |
Dicarboxylic aminoaciduria associated with mental retardation.
Topics: Amino Acids, Dicarboxylic; Aspartic Acid; Child; Female; Glutamates; Glutamic Acid; Humans; Intellectual Disability | 1989 |
Functional consequences of glutamate, aspartate, glutamine, and asparagine mutations in the stalk sector of the Ca2+-ATPase of sarcoplasmic reticulum.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Biological Transport; Calcium; Calcium-Transporting ATPases; Cell Line; Cloning, Molecular; Glutamates; Glutamic Acid; Glutamine; Immunoblotting; Microsomes; Molecular Sequence Data; Muscles; Mutation; Phosphorylation; Rabbits; Recombinant Fusion Proteins; Sarcoplasmic Reticulum; Transfection | 1989 |
Biochemical characterization of an autoradiographic method for studying excitatory amino acid receptors using L-[3H]glutamate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Binding, Competitive; Brain; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Software; Tritium | 1989 |
Characterization of deep dorsal horn neurones in the rat spinal cord in vitro: synaptic and excitatory amino acid induced excitations.
Topics: Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Spinal Cord; Synapses | 1989 |
Extracellular concentrations of aspartate and glutamate in rat neostriatum following chemical stimulation of frontal cortex.
Topics: Animals; Aspartic Acid; Bicuculline; Corpus Striatum; Frontal Lobe; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neural Pathways; Rats; Rats, Inbred Strains | 1989 |
Some observations on conserved polar side chains in immunoglobulin V-domains.
Topics: Aspartic Acid; Glutamates; Glutamic Acid; Glutamine; Humans; Hydrogen Bonding; Immunoglobulin Variable Region; Protein Conformation; Threonine; Tyrosine | 1989 |
Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Biological Transport; Calcium; Cell Survival; Cells, Cultured; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Protein Kinase C; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Transient increase of NMDA-binding sites in human hippocampus during development.
Topics: Adult; Aging; Aspartic Acid; Fetus; Glutamates; Glutamic Acid; Hippocampus; Humans; Infant; Infant, Newborn; Middle Aged; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Na-dependent L-glutamate transport by eel intestinal BBMV: role of K+ and Cl-.
Topics: Animals; Aspartic Acid; Biological Transport; Chlorides; Eels; Glutamates; Glutamic Acid; In Vitro Techniques; Intestinal Mucosa; Intestines; Membrane Potentials; Microvilli; Potassium; Sodium | 1989 |
Selective effects of serotonin upon excitatory amino acid-induced depolarizations of Purkinje cells in cerebellar slices from young rats.
Topics: Action Potentials; Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Bacteriorhodopsin mutants of Halobacterium sp. GRB. II. Characterization of mutants.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Bacteriorhodopsins; Base Sequence; Cloning, Molecular; Cysteine; Genes, Bacterial; Glutamates; Glutamic Acid; Glycine; Halobacterium; Molecular Sequence Data; Mutation; Protein Conformation; Tryptophan; Tyrosine | 1989 |
Developmental changes in the chemosensitivity of rat brain synaptoneurosomes to excitatory amino acids, estimated by inositol phosphate formation.
Topics: Aging; Animals; Aspartic Acid; Carbachol; Female; Frontal Lobe; Glutamates; Glutamic Acid; Inositol Phosphates; Male; N-Methylaspartate; Norepinephrine; Oxadiazoles; Quisqualic Acid; Rats; Sugar Phosphates; Synaptosomes | 1989 |
Vitamin K-dependent carboxylation. In vitro modification of synthetic peptides containing the gamma-carboxylation recognition site.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Carbocysteine; Carbon-Carbon Ligases; Cattle; Factor IX; Glutamates; Glutamic Acid; Ligases; Microsomes, Liver; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Prothrombin; Substrate Specificity; Vitamin K | 1989 |
Glycine potentiates the stimulation of inositol phospholipid hydrolysis by excitatory amino acids in primary cultures of cerebellar neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Drug Synergism; Glutamates; Glutamic Acid; Glycine; Hydrolysis; Inositol Phosphates; Magnesium; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Signal Transduction; Sugar Phosphates | 1989 |
Delayed rescue of N-methyl-D-aspartate receptor-mediated neuronal injury in cortical culture.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Valine | 1989 |
Metabolism of glutamine in lymphocytes.
Topics: Ammonia; Animals; Aspartic Acid; B-Lymphocytes; Carbon Dioxide; Cell Division; Citric Acid Cycle; Dipeptides; Female; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glutamine; Humans; Ketoglutaric Acids; Lymphocytes; Rats; T-Lymphocytes; Tumor Cells, Cultured | 1989 |
Inhibition by excitatory sulphur amino acids of the high-affinity L-glutamate transporter in synaptosomes and in primary cultures of cortical astrocytes and cerebellar neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Astrocytes; Cerebellum; Cerebral Cortex; Cysteine; Glutamates; Glutamic Acid; Mice; Molecular Conformation; Neurotransmitter Uptake Inhibitors; Stereoisomerism; Synaptosomes | 1989 |
Role of aspartate aminotransferase and mitochondrial dicarboxylate transport for release of endogenously and exogenously supplied neurotransmitter in glutamatergic neurons.
Topics: Aminooxyacetic Acid; Animals; Aspartate Aminotransferases; Aspartic Acid; Cells, Cultured; Cerebellum; Dicarboxylic Acids; Enzyme Inhibitors; Glutamates; Glutamic Acid; Mice; Mitochondria; Potassium; Succinates | 1989 |
Differential effects of ammonia and beta-methylene-DL-aspartate on metabolism of glutamate and related amino acids by astrocytes and neurons in primary culture.
Topics: Amino Acids; Ammonia; Animals; Aspartic Acid; Astrocytes; Brain; Cells, Cultured; Glutamates; Glutamic Acid; Mice; Neurons | 1989 |
Glutamate receptor activation in cultured cerebellar granule cells increases cytosolic free Ca2+ by mobilization of cellular Ca2+ and activation of Ca2+ influx.
Topics: Animals; Aspartic Acid; Benzofurans; Calcium; Calcium Channel Blockers; Cells, Cultured; Cerebellum; Cytosol; Fluorescent Dyes; Fura-2; Glutamates; Glutamic Acid; Inositol Phosphates; Kainic Acid; Mice; N-Methylaspartate; Receptors, Glutamate; Receptors, Neurotransmitter; Spectrometry, Fluorescence | 1989 |
Effects of excitant amino acids on acoustic responses of inferior colliculus neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Inferior Colliculi; N-Methylaspartate; Parasympathomimetics; Rats; Rats, Inbred Strains; Valine | 1989 |
Effects of modifying individual amino or carboxyl groups on the affinity of calmodulin for calcineurin.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding, Competitive; Brain; Calcineurin; Calmodulin; Calmodulin-Binding Proteins; Cattle; Glutamates; Glutamic Acid; Kinetics; Lysine; Male; Mathematics; Models, Molecular; Molecular Sequence Data; Phosphoprotein Phosphatases; Protein Binding; Protein Conformation; Swine; Testis | 1989 |
Actions of excitatory amino acids on somatostatin release from cortical neurons in primary cultures.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Fetus; Glutamates; Glutamic Acid; Glutamine; Glycine; Kinetics; Magnesium; N-Methylaspartate; Neurons; Neurotransmitter Agents; Rats; Somatostatin; Tetrodotoxin; Veratridine | 1989 |
Sprouting by intact Helisoma neurons: role for glutamate.
Topics: Animals; Aspartic Acid; Culture Media; Dendrites; Ganglia; Glutamates; Glutamic Acid; Molecular Weight; Nerve Growth Factors; Organ Culture Techniques; Snails | 1989 |
Potassium-induced release of endogenous glutamate and two as yet unidentified substances from the lateral line of Xenopus laevis.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Chromatography, High Pressure Liquid; Female; Glutamates; Glutamic Acid; Magnesium; Male; Perfusion; Potassium; Sense Organs; Xenopus laevis | 1989 |
Brain amino acid concentrations and Ca2+-dependent release in intractable depression assessed antemortem.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Calcium; Depressive Disorder; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Homocysteine; Humans; Male; Middle Aged | 1989 |
Mechanisms of action of new antiepileptic drugs.
Topics: Acetamides; Acetates; Amines; Aminocaproates; Aminopyridines; Anti-Anxiety Agents; Anticonvulsants; Aspartic Acid; Benzodiazepines; Benzodiazepinones; Clobazam; Cyclohexanecarboxylic Acids; Dibenzocycloheptenes; Dizocilpine Maleate; Epilepsy; Felbamate; Flumazenil; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Imidazoles; Lamotrigine; Phenylcarbamates; Propylene Glycols; Receptors, GABA-A; Triazines; Vigabatrin | 1989 |
A single amino acid substitution in the beta-adrenergic receptor promotes partial agonist activity from antagonists.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Aspartic Acid; Cell Membrane; Cricetinae; Genes; Glutamates; Glutamic Acid; Kinetics; L Cells; Mice; Models, Molecular; Molecular Conformation; Mutation; Receptors, Adrenergic, beta; Structure-Activity Relationship; Transfection | 1989 |
Changes in regional levels of putative neurotransmitter amino acids in brain under unilateral forebrain ischemia.
Topics: Animals; Aspartic Acid; Brain; Cerebral Cortex; Corpus Striatum; Female; gamma-Aminobutyric Acid; Gerbillinae; Glutamates; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Kinetics; Male | 1989 |
Measurement of amino acid release from cultured cerebellar granule cells by an improved high performance liquid chromatography procedure.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Taurine | 1989 |
Beta-DL-methylene-aspartate, an inhibitor of aspartate aminotransferase, potently inhibits L-glutamate uptake into astrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Aspartate Aminotransferases; Aspartic Acid; Astrocytes; Biological Transport; Glutamates; Glutamic Acid; Glycoproteins; Kinetics; Mice | 1989 |
Lack of excitatory amino acid-induced effects on calcium fluxes measured with 45Ca2+ in rat cerebral cortex synaptosomes.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Calcium Radioisotopes; Cerebral Cortex; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Magnesium; Male; N-Methylaspartate; Potassium; Rats; Rats, Inbred Strains; Synaptosomes; Temperature | 1989 |
Extracellular taurine increase in rat hippocampus evoked by specific glutamate receptor activation is related to the excitatory potency of glutamate agonists.
Topics: Action Potentials; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Release of endogenous excitatory amino acids and proteins by the mast cell degranulating peptide in the hippocampus.
Topics: Animals; Aspartic Acid; Bee Venoms; Glutamates; Glutamic Acid; Hippocampus; Male; Nerve Tissue Proteins; Peptides; Rats; Rats, Inbred Strains | 1989 |
Association of myocardial glutamate and aspartate pool and functional recovery of postischemic heart.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Coronary Disease; Creatine; Energy Metabolism; Glutamates; Glutamic Acid; Guinea Pigs; Histocytochemistry; Lactates; Lactic Acid; Male; Myocardial Contraction; Myocardium; Phosphocreatine | 1989 |
End products of glutamine oxidation in MC-29 virus-induced chicken hepatoma mitochondria.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Chickens; Citric Acid Cycle; Glutamates; Glutamic Acid; Glutamine; Lactates; Lactic Acid; Liver Neoplasms, Experimental; Malates; Mitochondria, Liver; Oxidation-Reduction; Pyruvates; Pyruvic Acid | 1989 |
Bidirectional transfer between kindling induced either by L-glutamate or L-aspartate and electrical stimulation in rats.
Topics: Amygdala; Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains | 1989 |
Effects of amygdaloid kindling on NMDA receptor function and regulation.
Topics: Amygdala; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kindling, Neurologic; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Multiple effects of phorbol esters in the rat spinal dorsal horn.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Calcium; Colforsin; Drug Synergism; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Phorbol Esters; Rats; Rats, Inbred Strains; Sodium; Spinal Cord; Synapses; Synaptic Transmission | 1989 |
The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granule cells.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Designer Drugs; Excitatory Amino Acid Antagonists; Glutamic Acid; Granulocytes; Monoamine Oxidase; Neurotoxins; Osmolar Concentration; Time Factors | 1989 |
Inhibition of rat brain glutamate receptors by philanthotoxin.
Topics: Animals; Aspartic Acid; Bee Venoms; Brain; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Wasp Venoms; Xenopus | 1989 |
Dilator effects of amino acid neurotransmitters on piglet pial arterioles.
Topics: 6-Ketoprostaglandin F1 alpha; Amino Acids; Animals; Arteries; Arterioles; Aspartic Acid; Blood Pressure; Cerebrovascular Circulation; Dinoprostone; Female; Glutamates; Glutamic Acid; Glycine; Isoproterenol; Male; Muscle, Smooth, Vascular; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Pia Mater; Reference Values; Swine; Taurine | 1989 |
Changes of the membrane potential in striatal synaptoneurosome, synaptosome and membrane sac preparations induced by glutamate, kainate and aspartate as measured with a cyanine dye DiS-C2-(5).
Topics: Animals; Aspartic Acid; Corpus Striatum; Dithiazanine; Fluorescent Dyes; Glutamates; Glutamic Acid; Guinea Pigs; Kainic Acid; Membrane Potentials; Synaptosomes | 1989 |
Kindling of full limbic seizures by repeated microinjections of excitatory amino acids into the rat amygdala.
Topics: Amygdala; Animals; Aspartic Acid; Drug Interactions; Glutamates; Glutamic Acid; Kindling, Neurologic; Male; Microinjections; Rats; Rats, Inbred Strains | 1989 |
Histidine and proline are important sites of free radical damage to proteins.
Topics: Animals; Aspartic Acid; Free Radicals; Glutamates; Glutamic Acid; Histidine; In Vitro Techniques; Proline; Proteins | 1989 |
Site-specific substitution of glutamate for aspartate at position 59 of rat oncomodulin.
Topics: Animals; Aspartic Acid; Calcium; Calcium-Binding Proteins; Cloning, Molecular; DNA; DNA Restriction Enzymes; DNA, Recombinant; Escherichia coli; Europium; Gene Expression; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Luminescent Measurements; Magnesium; Mutation; Neoplasm Proteins; Nucleic Acid Hybridization; Rats; Recombinant Proteins; RNA, Messenger; Spectrophotometry, Ultraviolet | 1989 |
Glutamate receptors of the N-methyl-D-aspartate subtype in the myenteric plexus of the guinea pig ileum.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Guinea Pigs; Ileum; Magnesium; Male; Muscle Contraction; Myenteric Plexus; N-Methylaspartate; Piperazines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Different modulation of the binding to two phencyclidine (PCP) receptor subtypes: effects of N-methyl-D-aspartate agonists and antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Glutamates; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cattle; Glutamates; Glutamic Acid; GTP Phosphohydrolases; Kinetics; Membrane Proteins; Molecular Sequence Data; Mutation; Protein Conformation; Retinal Pigments; Retinoids; Rhodopsin; Schiff Bases; Sequence Homology, Nucleic Acid; Transducin | 1989 |
Different classes of glutamate receptors mediate distinct behaviors in a single brainstem nucleus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Brain Stem; Electric Fish; Electric Organ; Glutamates; Glutamic Acid; Glutamine; Kainic Acid; N-Methylaspartate; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
Topics: Animals; Arginine; Aspartic Acid; Cerebellum; Citrulline; Cyclic GMP; Glutamates; Glutamic Acid; Hemoglobins; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Quisqualic Acid; Rats | 1989 |
A biochemical correlate of the critical period for synaptic modification in the visual cortex.
Topics: Aging; Animals; Aspartic Acid; Carbachol; Cattle; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methylaspartate; Ocular Physiological Phenomena; Phosphatidylinositols; Synapses; Vision, Ocular; Visual Cortex | 1989 |
Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Algorithms; Animals; Aspartic Acid; Extracellular Space; Glutamates; Glutamic Acid; Hippocampus; Least-Squares Analysis; Magnesium; Microelectrodes; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1989 |
Effect of carboxylic acid side chains on the absorption maximum of visual pigments.
Topics: Aspartic Acid; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Hydroxylamine; Hydroxylamines; Models, Molecular; Mutation; Protein Conformation; Retinal Pigments; Retinaldehyde; Retinoids; Rhodopsin; Schiff Bases; Spectrophotometry | 1989 |
Site-specific mutants of oncomodulin. 1H NMR and optical stopped-flow studies of the effect on the metal binding properties of an Asp59----Glu59 substitution in the calcium-specific site.
Topics: Animals; Aspartic Acid; Binding Sites; Calcium; Calcium-Binding Proteins; Glutamates; Glutamic Acid; Kinetics; Liver Neoplasms, Experimental; Magnetic Resonance Spectroscopy; Mutation; Neoplasm Proteins; Protein Conformation; Rats; Recombinant Proteins | 1989 |
D-aspartate potentiates the effects of both L-aspartate and L-glutamate on carp horizontal cells.
Topics: Animals; Aspartic Acid; Carps; Cyprinidae; Drug Interactions; Glutamates; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Retina | 1989 |
N-methyl-D-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis and Papio papio).
Topics: Animals; Aspartic Acid; Binding, Competitive; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Hippocampus; N-Methylaspartate; Papio; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Hypoxia/hypotension evoked release of glutamate and aspartate from the rat cerebral cortex.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; Hypotension; Hypoxia, Brain; Male; Rats; Rats, Inbred Strains | 1989 |
A high performance liquid chromatography/electrochemical assay for glutamatergic neurotransmitters in the rat brain.
Topics: Animals; Aspartic Acid; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Electrochemistry; Glutamates; Glutamic Acid; Glutamine; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains | 1989 |
Excitatory transmitter amino acid-containing neurons in the rat visual cortex: a light and electron microscopic immunocytochemical study.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Immunohistochemistry; Rats; Visual Cortex | 1989 |
Stimulation of pituitary hormone secretion by neurotransmitter amino acids in humans.
Topics: Adrenocorticotropic Hormone; Adult; Amino Acids; Aspartic Acid; Cysteine; Female; Glutamates; Glutamic Acid; Growth Hormone; Humans; Hydrocortisone; Luteinizing Hormone; Male; Neurotransmitter Agents; Pituitary Gland; Pituitary Hormones; Prolactin; Taurine; Thyrotropin | 1989 |
Evidence for evoked release of adenosine and glutamate from cultured cerebellar granule cells.
Topics: Adenosine; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Kainic Acid; Mice; Potassium Chloride; Tritium | 1989 |
Anionic amino acid uptake by microvillous membrane vesicles from human placenta.
Topics: Amino Acids; Anions; Aspartic Acid; Electrochemistry; Female; Glutamates; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Microvilli; Osmolar Concentration; Placenta; Potassium; Potassium Chloride; Pregnancy; Sodium; Time Factors | 1989 |
Stimulation of glutamine metabolism by the antiepileptic drug, sodium valproate, in isolated dog kidney tubules.
Topics: Alanine; Ammonia; Animals; Aspartic Acid; Dogs; Female; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Kidney Tubules; Lactates; Lactic Acid; Male; Pyruvates; Pyruvic Acid; Valproic Acid | 1989 |
Selective inhibition of excitatory amino acids by divalent cations. A novel means for distinguishing N-methyl-D-aspartic acid-, kainate- and quisqualate-mediated actions in the mouse spinal cord.
Topics: Animals; Aspartic Acid; Behavior, Animal; Calcium; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; Male; Mice; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Spinal Cord; Zinc | 1989 |
Aspartate-releasing nerve terminals in rat striatum possess D-2 dopamine receptors mediating inhibition of release.
Topics: Animals; Aspartic Acid; Calcium; Corpus Striatum; Dopamine; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Sulpiride | 1989 |
Glial uptake of excitatory amino acids influences neuronal survival in cultures of mouse hippocampus.
Topics: Action Potentials; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Culture Media; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroglia; Phosphopyruvate Hydratase; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Characterization of a transport system for anionic amino acids in human fibroblast lysosomes.
Topics: Amino Acids; Aspartic Acid; Biological Transport; Cells, Cultured; Fibroblasts; Glutamates; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Lysosomes | 1989 |
Effects of glucose deficiency on glutamate/aspartate release and excitatory synaptic responses in the hippocampal CA1 area in vitro.
Topics: Animals; Aspartic Acid; Energy Metabolism; Female; Glucose; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Potassium; Rats; Rats, Inbred Strains; Synaptic Transmission | 1989 |
[Functional growth retardation and its correction].
Topics: Adolescent; Anabolic Agents; Arginine; Aspartic Acid; Child; Clomiphene; Drug Therapy, Combination; Female; Glutamates; Glutamic Acid; Growth Disorders; Humans; Male; Nandrolone; Nandrolone Decanoate | 1989 |
beta-Amyloid precursor is a PEST protein.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain Chemistry; Calpain; Glutamates; Glutamic Acid; Molecular Sequence Data; Proline; Protease Inhibitors; Protein Precursors; Rats; Serine; Threonine | 1989 |
Inhibition of N-methyl-D-aspartate (NMDA)- and L-glutamate-induced noradrenaline and acetylcholine release in the rat brain by ethanol.
Topics: Acetylcholine; Animals; Aspartic Acid; Calcium; Cerebral Cortex; Choline; Corpus Striatum; Ethanol; Glutamates; Glutamic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Tritium; Veratridine | 1989 |
Cerebellar granule cell survival and maturation induced by K+ and NMDA correlate with c-fos proto-oncogene expression.
Topics: Animals; Aspartic Acid; Cell Survival; Cerebellum; Glutamates; Glutamic Acid; Mice; N-Methylaspartate; Potassium; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Substitution of membrane-embedded aspartic acids in bacteriorhodopsin causes specific changes in different steps of the photochemical cycle.
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspartic Acid; Bacteriorhodopsins; Cell Membrane; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Lipid Bilayers; Molecular Sequence Data; Mutation; Photochemistry | 1989 |
Bicuculline- and phaclofen-sensitive components of N-methyl-D-aspartate-induced hyperpolarizations in rat dorsolateral septal nucleus neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Baclofen; Bicuculline; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Septal Nuclei; Tetrodotoxin | 1989 |
A genetic locus for the GltII-glutamate transport system in Escherichia coli.
Topics: Aspartic Acid; Biological Transport, Active; Chromosome Mapping; Drug Resistance, Microbial; Escherichia coli; Genes, Bacterial; Glutamates; Glutamic Acid; Mutation; Phenotype | 1989 |
Release of [3H]dopamine from rat prefrontal cortex: modulation through presynaptic cholinergic heteroreceptors.
Topics: Animals; Aspartic Acid; Calcium Channel Blockers; Carbachol; Cerebral Cortex; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Nerve Endings; Neurotransmitter Agents; Parasympathetic Nervous System; Potassium; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin; Synapses | 1989 |
Some properties of ionic channels activated by excitatory amino acids in hippocampal neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Electric Conductivity; Electric Stimulation; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Homocysteine; In Vitro Techniques; Ion Channels; Manganese; Oxadiazoles; Quisqualic Acid | 1985 |
The effects of potassium channel blocking agents on the responses of in vitro frog motoneurones to glutamate and other excitatory amino acids: an intracellular study.
Topics: Amino Acids; Animals; Aspartic Acid; Cell Membrane; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Ion Channels; N-Methylaspartate; Oxadiazoles; Potassium; Quisqualic Acid; Rana temporaria; Spinal Cord | 1985 |
The action of N-methyl-D-aspartic acid on mouse spinal neurones in culture.
Topics: Action Potentials; Animals; Aspartic Acid; Cells, Cultured; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Spinal Cord; Time Factors | 1985 |
Excitatory amino acid-induced responses of frog motoneurones bathed in low Na+ media: an intracellular study.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Ion Channels; Membrane Potentials; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana temporaria; Sodium; Spinal Cord | 1985 |
Release of D-[3H]aspartic acid from the rat striatum. Effect of veratridine-evoked depolarization, fronto-parietal cortex ablation, and striatal lesions with kainic acid.
Topics: Animals; Aspartic Acid; Calcium; Cerebral Cortex; Corpus Striatum; Frontal Lobe; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Male; Membrane Potentials; Neural Pathways; Neurotransmitter Agents; Parietal Lobe; Potassium; Rats; Rats, Inbred Strains; Tetrodotoxin; Veratridine | 1985 |
Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum.
Topics: Animals; Aspartic Acid; Corpus Striatum; Female; Glutamates; Glutamic Acid; Kainic Acid; Rats; Rats, Inbred Strains | 1985 |
Effect of carbohydrate ingestion on plasma aspartate concentrations in infant mice administered sodium L-aspartate.
Topics: Animals; Aspartic Acid; Dietary Carbohydrates; Glutamates; Glutamic Acid; Mice | 1985 |
beta-N-Oxalylamino-L-alanine: action on high-affinity transport of neurotransmitters in rat brain and spinal cord synaptosomes.
Topics: Alanine; Amino Acids, Diamino; Animals; Aspartic Acid; beta-Alanine; Biological Transport, Active; Brain; Choline; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Spinal Cord; Synaptosomes | 1985 |
Effect of hypoglycemic encephalopathy upon amino acids, high-energy phosphates, and pHi in the rat brain in vivo: detection by sequential 1H and 31P NMR spectroscopy.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Electroencephalography; Glutamates; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Hypoglycemia; Insulin; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Nucleotides; Phosphates; Phosphocreatine; Rats | 1985 |
Stimulus- and amino acid-induced calcium and potassium changes in rat neocortex.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cerebral Cortex; Electric Stimulation; Electrophysiology; Extracellular Space; Glutamates; Glutamic Acid; Male; Potassium; Rats; Tetrodotoxin | 1985 |
Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Corpus Callosum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Ketamine; Male; Muscimol; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Tetrodotoxin | 1985 |
Evoked efflux of [3H]GABA from goldfish retina in the dark.
Topics: Animals; Aspartic Acid; Autoradiography; Cyprinidae; Darkness; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Goldfish; Retina | 1985 |
N-Methyl-D-aspartate (NMDA), kainate and quisqualate receptors and the generation of fictive locomotion in the lamprey spinal cord.
Topics: Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; Lampreys; Levodopa; Locomotion; Receptors, AMPA; Receptors, Cell Surface; Receptors, Drug; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1985 |
Immunocytochemical localizations of cytosolic and mitochondrial glutamic oxaloacetic transaminase isozymes in rat retina as markers for the glutamate-aspartate neuronal system.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Cytosol; Fluorescent Antibody Technique; Glutamates; Glutamic Acid; Isoenzymes; Mitochondria; Neural Pathways; Rats; Retina; Synaptic Transmission | 1985 |
Roles of aspartate and glutamate in synaptic transmission in rabbit retina. I. Outer plexiform layer.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Neurotransmitter Agents; Rabbits; Retina; Synaptic Transmission | 1985 |
Roles of aspartate and glutamate in synaptic transmission in rabbit retina. II. Inner plexiform layer.
Topics: Aminobutyrates; Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Neurons; Rabbits; Retina; Retinal Ganglion Cells; Synaptic Transmission | 1985 |
In vivo studies on amino acid transmitters in the central auditory system of the guinea pig.
Topics: 4-Chloromercuribenzenesulfonate; Acoustic Stimulation; Alanine; Amino Acids; Animals; Aspartic Acid; Cochlear Nerve; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Male; Neurotransmitter Agents; Vestibulocochlear Nerve | 1985 |
Central GABA-ergic mechanism in stress-induced gastric ulceration.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Bicuculline; Cold Temperature; Epinephrine; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Humans; Hydrogen-Ion Concentration; Injections, Intraventricular; Male; Neurotransmitter Agents; Picrotoxin; Pylorus; Rats; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Valproic Acid | 1985 |
Modulatory effects of prostaglandin D2, E2 and F2 alpha on the postsynaptic actions of inhibitory and excitatory amino acids in cerebellar Purkinje cell dendrites in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Dinoprost; Dinoprostone; Drug Interactions; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Prostaglandin D2; Prostaglandins; Prostaglandins D; Prostaglandins E; Prostaglandins F; Purkinje Cells; Synaptic Transmission; Taurine | 1985 |
Effect of glutamine on glutamate release from hippocampal slices induced by high K+ or by electrical stimulation: interaction with different Ca2+ concentrations.
Topics: Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Electric Stimulation; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Hippocampus; In Vitro Techniques; Potassium; Rats; Rats, Inbred Strains | 1985 |
Effects of anti-glutamate-binding protein antibodies on synaptic membrane ion flux, glutamate transport and release, and L-glutamate binding activities.
Topics: Animals; Antibodies; Aspartic Acid; Biological Transport; Cattle; Glutamates; Glutamic Acid; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium; Synaptic Membranes; Thiocyanates | 1985 |
Effects of ammonium salts on synaptic transmission to hippocampal CA1 and CA3 pyramidal cells in vivo.
Topics: Acetates; Action Potentials; Ammonium Chloride; Animals; Aspartic Acid; Drug Interactions; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Male; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Synaptic Transmission | 1985 |
Identification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids.
Topics: Amino Acids; Animals; Arousal; Aspartic Acid; Bicuculline; Glutamates; Glutamic Acid; Male; Neurons; Periaqueductal Gray; Rats; Rats, Inbred Strains; Tegmentum Mesencephali | 1985 |
Excitotoxin lesions suggest an aspartatergic projection from rat medial prefrontal cortex to ventral tegmental area.
Topics: Animals; Aspartic Acid; Efferent Pathways; Frontal Lobe; Glutamates; Glutamic Acid; N-Methylaspartate; Rats; Synaptic Transmission; Tegmentum Mesencephali | 1985 |
Effects of zinc on markers of glutamate and aspartate neurotransmission in rat hippocampus.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptic Transmission; Zinc | 1985 |
Receptor types mediating the excitatory actions of exogenous L-aspartate and L-glutamate in rat olfactory cortex.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Limbic System; Olfactory Pathways; Rats; Receptors, Amino Acid; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1985 |
Aspartate and glutamate as synaptic transmitters of parallel visual cortical pathways.
Topics: Animals; Aspartic Acid; Cats; Female; Glutamates; Glutamic Acid; Male; Synapses; Synaptic Transmission; Visual Cortex | 1985 |
Schistosoma mansoni, S. japonicum, and S. haematobium: permeability to acidic amino acids and effect of separated and unseparated adults.
Topics: Animals; Aspartic Acid; Cell Membrane Permeability; Copulation; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; Schistosoma haematobium; Schistosoma japonicum; Schistosoma mansoni; Sex Factors; Time Factors | 1985 |
Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro.
Topics: Animals; Aspartic Acid; Astrocytes; Brain; Calcium; Cells, Cultured; Cerebellum; Dialysis; Glutamates; Glutamic Acid; Hippocampus; Hypoglycemia; Hypoxia; Ischemic Attack, Transient; Male; Mice; Neurons; Potassium; Rats; Rats, Inbred Strains | 1985 |
Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia.
Topics: Adult; Aged; Alzheimer Disease; Amino Acids; Aspartic Acid; Dementia; Epilepsy; Female; Glutamates; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Neurotransmitter Agents | 1985 |
N-Acetylaspartylglutamate: possible role as the neurotransmitter of the lateral olfactory tract.
Topics: Animals; Aspartic Acid; Central Nervous System; Dipeptides; Electrophysiology; Glutamates; Glutamic Acid; Neurons; Neurotransmitter Agents; Olfactory Pathways; Rats; Rats, Inbred Strains | 1985 |
Excitatory effects of L-glutamate and some analogs on isolated horizontal cells from the catfish retina.
Topics: Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Retina | 1985 |
Interaction of soluble pig heart glutamate-aspartate transaminase with various beta,gamma-unsaturated amino acids.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Kinetics; Liver; Myocardium; Swine | 1985 |
Anticonvulsant action of beta-kainic acid in mice. Is beta-kainic acid an N-methyl-D-aspartate antagonist?
Topics: Animals; Anticonvulsants; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Homocysteine; Kainic Acid; Mice; N-Methylaspartate; Oxadiazoles; Pyrrolidines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Seizures; Stereoisomerism | 1985 |
Effects of excitatory amino acids on calcium transport by brain membranes.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Brain Chemistry; Calcium; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Neurotransmitter Agents; Synaptosomes | 1985 |
Calcium influx accompanies but does not cause excitotoxin-induced neuronal necrosis in retina.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Aspartic Acid; Calcium; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Mice; N-Methylaspartate; Necrosis; Nicotinic Acids; Nimodipine; Pyrrolidines; Retina | 1985 |
The effects of putative amino acid neurotransmitters on somata isolated from neurons of the locust central nervous system.
Topics: Action Potentials; Animals; Aspartic Acid; Cysteine; Female; gamma-Aminobutyric Acid; Ganglia; Glutamates; Glutamic Acid; Grasshoppers; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Membrane Potentials; Neurons; Neurotransmitter Agents; Taurine | 1985 |
Anticonvulsant properties of 3-hydroxy-2-quinoxalinecarboxylic acid, a newly found antagonist of excitatory amino acids.
Topics: Animals; Anticonvulsants; Aspartic Acid; Electroencephalography; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Picrotoxin; Pyrrolidines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Structure-Activity Relationship | 1985 |
Controlled induction of paired helical filaments of the Alzheimer type in cultured human neurons, by glutamate and aspartate.
Topics: Alzheimer Disease; Aspartic Acid; Culture Techniques; Cytoskeleton; Fetus; Glutamates; Glutamic Acid; Humans; Microscopy, Electron; Models, Neurological; Neurofibrils; Spinal Cord | 1985 |
Pharmacological characterization of postsynaptic receptors for excitatory amino acids in Purkinje cell dendrites in the guinea pig cerebellum.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dendrites; Dipeptides; Drug Synergism; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Purkinje Cells; Receptors, Neurotransmitter | 1985 |
Aspartame. Review of safety issues. Council on Scientific Affairs.
Topics: Adolescent; Adult; Animals; Aspartame; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Carbonated Beverages; Carcinogens; Child; Dietary Carbohydrates; Diketopiperazines; Dipeptides; Drug Stability; Endocrine System Diseases; Female; Glutamates; Glutamic Acid; Humans; Infant; Intellectual Disability; Methanol; Mice; Neurotransmitter Agents; Phenylalanine; Phenylketonurias; Piperazines; Pregnancy; Rats | 1985 |
Transport of monoamine and amino acid neurotransmitters by primary astroglial cultures.
Topics: Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Cells, Cultured; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kinetics; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin | 1985 |
Specific interaction between tRNA and its cognate amino acid as detected by circular dichroism and fluorescence spectroscopy.
Topics: Anticodon; Aspartic Acid; Circular Dichroism; Escherichia coli; Glutamates; Glutamic Acid; Isomerism; Kinetics; Nucleic Acid Conformation; RNA, Transfer, Amino Acyl; Spectrometry, Fluorescence | 1985 |
Synaptic transmission between dorsal root ganglion and dorsal horn neurons in culture: antagonism of monosynaptic excitatory postsynaptic potentials and glutamate excitation by kynurenate.
Topics: Animals; Aspartic Acid; Cells, Cultured; Evoked Potentials; Female; Ganglia, Spinal; Glutamates; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Pregnancy; Rats; Spinal Cord; Synaptic Transmission | 1985 |
Further localization of midbrain neurones mediating the defence reaction in the cat by microinjections of excitatory amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Cats; Defense Mechanisms; Electric Stimulation; Glutamates; Glutamic Acid; Homocysteine; Humans; Injections, Intraventricular; Mesencephalon; Neurons; Periaqueductal Gray; Reaction Time | 1985 |
Plasma glutamate concentrations in adult subjects ingesting monosodium L-glutamate in consomme.
Topics: Adult; Analysis of Variance; Aspartic Acid; Female; Food; Glutamates; Glutamic Acid; Humans; Male; Sodium Glutamate | 1985 |
Cellular uptake disguises action of L-glutamate on N-methyl-D-aspartate receptors. With an appendix: diffusion of transported amino acids into brain slices.
Topics: Aging; Animals; Aspartic Acid; Biological Transport; Brain; Cyclic GMP; Diffusion; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1985 |
L-[3H]Glutamate binds to kainate-, NMDA- and AMPA-sensitive binding sites: an autoradiographic analysis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Chemistry; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1985 |
"Epileptic" brain damage is replicated qualitatively in the rat hippocampus by central injection of glutamate or aspartate but not by GABA or acetylcholine.
Topics: Acetylcholine; Animals; Aspartic Acid; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Hippocampus; Immunoenzyme Techniques; Injections, Intraventricular; Male; Motor Activity; Nerve Degeneration; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Purine nucleoside and nucleotide regulation of high affinity [3H]glutamate and [3H]aspartate uptake into rat brain synaptosomes.
Topics: Animals; Aspartic Acid; Biological Transport; Brain; Glutamates; Glutamic Acid; Kinetics; Purine Nucleosides; Purine Nucleotides; Rats; Structure-Activity Relationship; Synaptosomes | 1985 |
Diphtheria toxin. Effect of substituting aspartic acid for glutamic acid 148 on ADP-ribosyltransferase activity.
Topics: Aspartic Acid; Base Sequence; Binding Sites; Cloning, Molecular; Corynebacterium diphtheriae; Diphtheria Toxin; Escherichia coli; Genes; Genes, Bacterial; Glutamates; Glutamic Acid; Mutation; NAD; Nucleotidyltransferases; Poly(ADP-ribose) Polymerases; Protein Binding | 1985 |
Methionine-induced changes in glutamate, aspartate, glutamine, and gamma-aminobutyrate levels in brain tissue.
Topics: Animals; Aspartic Acid; Brain Chemistry; Convulsants; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Isoniazid; Ketoglutaric Acids; Male; Methionine; Mice; Nerve Endings; Rats; Rats, Inbred Strains; Synaptosomes | 1985 |
Pharmacological evidence for L-aspartate as the neurotransmitter of cerebellar climbing fibres in the guinea-pig.
Topics: Action Potentials; Animals; Aspartic Acid; Cerebellum; Dendrites; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Nerve Fibers; Neurotransmitter Agents; Purkinje Cells; Time Factors | 1985 |
Effects of short-term and prolonged aerogenic hypoxia on gamma-glutamyl transpeptidase activity in the brain, liver, and biological fluids of young rats.
Topics: Altitude; Animals; Aspartic Acid; Body Fluids; Brain; Female; gamma-Glutamyltransferase; Glutamates; Glutamic Acid; Glutamine; Hypoxia; Liver; Male; Rats; Rats, Inbred Strains | 1985 |
Effects of bath-applied excitatory amino acids and their analogs on spinal interneurons of the lamprey.
Topics: Amino Acids; Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; Glycine; Homocysteine; In Vitro Techniques; Interneurons; Kainic Acid; Lampreys; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Spinal Cord | 1985 |
Stimulated release of endogenous GABA and glycine from the goldfish retina.
Topics: Animals; Aspartic Acid; Calcium; Cyprinidae; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Goldfish; In Vitro Techniques; Magnesium; Potassium; Retina; Stereoisomerism | 1985 |
Monoamine, amino acid and cholinergic interactions in slices of rat cerebral cortex.
Topics: Amino Acids; Animals; Aspartic Acid; Biogenic Amines; Carbachol; Cerebral Cortex; Dopamine; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Neurotransmitter Agents; Norepinephrine; Rats; Serotonin | 1985 |
Stimulation of photoreceptor disc shedding and pigment epithelial phagocytosis by glutamate, aspartate, and other amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Cell Membrane; Choline; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Organ Culture Techniques; Ouabain; Phagocytosis; Photic Stimulation; Photoreceptor Cells; Pigment Epithelium of Eye; Potassium Chloride; Xenopus laevis | 1985 |
Actions of neurotransmitters on pontine medical reticular formation neurons of the cat.
Topics: Acetylcholine; Animals; Aspartic Acid; Cats; Electric Conductivity; Evoked Potentials; Glutamates; Glutamic Acid; Glycine; Membrane Potentials; Neurons; Neurotransmitter Agents; Pons; Reticular Formation; Serotonin | 1985 |
L-Homocysteic acid as an alternative cytotoxin for studying glutamate-induced cellular degeneration of Huntington's disease and normal skin fibroblasts.
Topics: Aspartic Acid; Cell Survival; Cells, Cultured; Cysteic Acid; Cysteine; Fibroblasts; Glutamates; Glutamic Acid; Homocysteine; Humans; Huntington Disease; In Vitro Techniques; Isomerism; Kainic Acid; Kinetics; N-Methylaspartate; Neurotransmitter Agents; Skin; Time Factors | 1985 |
Serine synthesis by an isolated perfused rat kidney preparation.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glycerol; Kidney; Male; Perfusion; Picolinic Acids; Rats; Rats, Inbred Strains; Serine | 1985 |
Inhibitors of high-affinity uptake augment depolarizations of hippocampal neurons induced by glutamate, kainate and related compounds.
Topics: Animals; Aspartic Acid; Drug Synergism; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Homocysteine; In Vitro Techniques; Kainic Acid; Oxadiazoles; Quisqualic Acid; Synaptic Transmission | 1985 |
Kainic acid differentially affects the synaptosomal release of endogenous and exogenous amino acidic neurotransmitters.
Topics: Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Goldfish; Hippocampus; Kainic Acid; Magnesium; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Synaptosomes | 1985 |
Maternal undernutrition during lactation: effect on amino acids in brain regions of offspring.
Topics: Amino Acids; Animals; Aspartic Acid; Body Weight; Brain Chemistry; Corpus Striatum; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Hippocampus; Hypothalamus; Lactation; Nutrition Disorders; Pregnancy; Rats; Rats, Inbred Strains; Serine; Taurine | 1985 |
Induced release of gamma-aminobutyric acid by a carrier-mediated, high-affinity uptake of L-glutamate in cultured chick retina cells.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Chick Embryo; Cobalt; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Lithium; Magnesium; Retina; Sodium | 1985 |
Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Glutamates; Glutamic Acid; Kinetics; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tissue Distribution | 1985 |
Properties of the uptake and release of neurotransmitter glutamate in cerebral cortical tissue of guinea pigs.
Topics: Animals; Aspartic Acid; Biological Transport, Active; Cerebral Cortex; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Neuroglia; Neurotransmitter Agents; Potassium; Sodium; Synaptosomes | 1985 |
Peptides derived from kainic acid as antagonists of N-methyl-D-aspartate-induced neuroexcitation in rat brain.
Topics: Animals; Aspartic Acid; Corpus Striatum; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats | 1985 |
Excitatory and inhibitory responses of Purkinje cells, in the rat cerebellum in vivo, induced by excitatory amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Excitatory and inhibitory amino acid neurotransmitters and ammonia metabolism in hepatic failure rats.
Topics: Ammonia; Animals; Aspartic Acid; Brain; Carbon Tetrachloride Poisoning; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Liver Diseases; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains | 1985 |
[Mechanisms of ammonia binding in the heart muscle].
Topics: Alanine; Amino Acids; Ammonia; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Male; Myocardial Infarction; Myocardium; Rats; Rats, Inbred Strains; Urea | 1985 |
Calcium and unit response decrement to locally applied glutamate on rat hippocampal CA1 neurons.
Topics: Animals; Aspartic Acid; Calcium; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Iontophoresis; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains | 1985 |
Aspartate metabolism in rats during aging.
Topics: Aging; Animals; Aspartic Acid; Brain; Carbon Dioxide; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains | 1985 |
Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus.
Topics: Animals; Aspartic Acid; Calcium; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Male; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Spinal Cord | 1986 |
A dipeptide derived from kainic and L-glutamic acids: a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties.
Topics: Animals; Aspartic Acid; Cell Membrane Permeability; Corpus Striatum; Dipeptides; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Oxadiazoles; Picrotoxin; Quisqualic Acid; Rats; Seizures; Sodium | 1985 |
Hepatic coma and amino acids in the nerve endings of the central nervous system.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Hepatic Encephalopathy; Humans; In Vitro Techniques; Male; Nerve Endings; Neurotransmitter Agents; Potassium; Rats; Rats, Inbred Strains; Synaptosomes; Threonine | 1985 |
Changes in cortical amino acids during electrical kindling in rats.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Electric Stimulation; Glutamates; Glutamic Acid; Glutamine; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Veratrine | 1985 |
Long-term potentiation of synaptic transmission in the dentate gyrus: increased release of [14C]glutamate without increase in receptor binding.
Topics: Animals; Aspartic Acid; Calcium; Carbon Radioisotopes; Glutamates; Glutamic Acid; Hippocampus; Male; Potassium; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Stimulation, Chemical; Synapses; Synaptic Transmission; Time Factors | 1985 |
Elevated concentrations of glutamate and aspartate in human ventricular cerebrospinal fluid (vCSF) during episodes of increased CSF pressure and clinical signs of impaired brain circulation.
Topics: Adult; Aged; Amino Acids; Aspartic Acid; Brain Ischemia; Female; Glutamates; Glutamic Acid; Humans; Hydrocephalus; Intracranial Pressure; Male; Middle Aged; Osmolar Concentration; Tomography, X-Ray Computed | 1985 |
Climbing and parallel fiber responses recorded intracellularly from Purkinje cell dendrites in guinea pig cerebellar slices.
Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Cesium; Dendrites; Electric Conductivity; Electric Stimulation; Glutamates; Glutamic Acid; Guinea Pigs; Magnesium; Male; Membrane Potentials; Nerve Fibers; Purkinje Cells; Reaction Time | 1985 |
Kainic acid-induced changes of extracellular amino acid levels, evoked potentials and EEG activity in the rabbit olfactory bulb.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Electroencephalography; Evoked Potentials; Extracellular Space; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Olfactory Bulb; Rabbits; Time Factors | 1985 |
The role of putative excitatory amino acid neurotransmitters in the initiation of locomotion in the lamprey spinal cord. II. The effects of amino acid uptake inhibitors.
Topics: Amino Acids; Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Lampreys; Locomotion; N-Methylaspartate; Neurotransmitter Agents; Spinal Cord; Synaptic Transmission | 1985 |
Selective excitation of neurons in the mammalian spinal dorsal horn by aspartate and glutamate in vitro: correlation with location and excitatory input.
Topics: Animals; Aspartic Acid; Calcium; Cricetinae; Glutamates; Glutamic Acid; In Vitro Techniques; Iontophoresis; Male; Mesocricetus; Nerve Fibers; Spinal Cord; Stimulation, Chemical | 1985 |
Pharmacological properties of gamma-aminobutyric acid-, glutamate-, and aspartate-induced depolarizations in cultured astrocytes.
Topics: Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Muscimol; Rats | 1985 |
Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1986 |
Protective effects of glutamate and aspartate on the ischemic and reperfused myocardium of hearts from starved rats.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Aspartic Acid; Cardiac Output; Coronary Circulation; Glutamates; Glutamic Acid; Heart; Heart Arrest, Induced; Lactates; Lactic Acid; Male; Myocardium; Oxygen Consumption; Perfusion; Rats; Rats, Inbred Strains; Starvation | 1985 |
Assessment of some transmitter actions in rat cerebellar slices.
Topics: Animals; Aspartic Acid; Calcium; Carbachol; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Neurotransmitter Agents; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Secretory Rate | 1986 |
Function and metabolism of dog heart in ischemia and in subsequent reperfusion: effect of exogenous glutamic acid.
Topics: Alanine; Ammonia; Animals; Aspartic Acid; Coronary Disease; Dogs; Female; Glutamates; Glutamic Acid; Glutamine; Heart; Lactates; Male; Myocardial Contraction; Myocardium; Perfusion; Pyruvates | 1985 |
Carbon isotopic fractionation in heterotrophic microbial metabolism.
Topics: Acetates; Aspartic Acid; Carbon Isotopes; Citrates; Escherichia coli; Glucose; Glutamates; Glutamic Acid; Isotope Labeling; Kinetics | 1985 |
Action of excitatory amino acids and their antagonists on hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Guinea Pigs; Hippocampus; Iontophoresis; Manganese; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Tetrodotoxin; Valine | 1985 |
Changes in gamma-aminobutyrate, glutamate, aspartate, glycine, and taurine contents in the striatum after unilateral nigrostriatal lesions in rats.
Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Male; Neural Pathways; Neurotransmitter Agents; Rats; Substantia Nigra; Taurine | 1986 |
Studies on neurotransmitter markers and neuronal cell density in the cerebellar system in olivopontocerebellar atrophy and cortical cerebellar atrophy.
Topics: Adult; Aged; Aspartic Acid; Brain Stem; Cell Count; Cerebellar Cortex; Cerebellar Diseases; Choline O-Acetyltransferase; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Neurons; Neurotransmitter Agents; Olivary Nucleus; Pons | 1985 |
[Comparative sensitivity of the somas and dendrites of pyramidal neurons of the hippocampus to glutamate, aspartate and GABA in isolated sections of rat brain].
Topics: Animals; Aspartic Acid; Dendrites; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Rats | 1985 |
Neurotransmitter receptors in olivopontocerebellar atrophy: an autoradiographic study.
Topics: Aged; Aspartic Acid; Atrophy; Autoradiography; Binding Sites; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; In Vitro Techniques; Male; Middle Aged; Olivary Nucleus; Pons; Purkinje Cells; Receptors, Cholinergic; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Neurotransmitter | 1986 |
The characterization of intestinal acidic amino-acid transport.
Topics: Animals; Aspartic Acid; Binding, Competitive; Biological Transport, Active; Chickens; Diflunisal; Electrochemistry; Glutamates; Glutamic Acid; Indicators and Reagents; Intestinal Mucosa; Membrane Potentials; Methylglucosides; Onium Compounds; Organophosphorus Compounds; Potassium; Sodium | 1985 |
The role of amino acid catabolism in the formation of the tricarboxylic acid cycle intermediates and ammonia in anoxic rat heart.
Topics: Adenine Nucleotides; Aerobiosis; Amino Acids; Ammonia; Anaerobiosis; Animals; Aspartic Acid; Citric Acid Cycle; Glutamates; Glutamic Acid; Male; Muscle Proteins; Myocardium; Oxygen; Rats; Rats, Inbred Strains | 1986 |
Desensitization to glutamate and aspartate in rat olfactory (prepyriform) cortex slice.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Limbic System; Neuromuscular Junction; Neurotransmitter Agents; Olfactory Pathways; Receptors, Amino Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1986 |
[Effect of hypochloric solutions on the electrophysiologic processes of smooth muscles].
Topics: Animals; Aspartic Acid; Chlorides; Colon; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Propionates; Rats; Stomach | 1985 |
Induction of glutamate binding sites in hippocampal membranes by transient exposure to high concentrations of glutamate or glutamate analogs.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Aminobutyrates; Animals; Aspartic Acid; Binding Sites; Chlorides; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Saponins; Sodium; Valine | 1986 |
Different neuronal localization of aspartate-like and glutamate-like immunoreactivities in the hippocampus of rat, guinea-pig and Senegalese baboon (Papio papio), with a note on the distribution of gamma-aminobutyrate.
Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Immunoenzyme Techniques; In Vitro Techniques; Male; Papio; Rats; Rats, Inbred Strains | 1985 |
The association of [3H]D-aspartate binding and high-affinity glutamate uptake in the human brain.
Topics: Aspartic Acid; Binding Sites; Brain; Cerebellum; Cerebral Cortex; Glutamates; Glutamic Acid; Humans; Ligands; Stereoisomerism | 1986 |
Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors.
Topics: Age Factors; Aminobutyrates; Animals; Aspartic Acid; Drug Interactions; Glutamates; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Norepinephrine; Oxadiazoles; Oxazoles; Phosphatidylinositols; Phosphoserine; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Amino Acid; Receptors, Cell Surface | 1986 |
[Effect of excitant amino acid antagonists on glutamate receptors in the locust and on convulsions induced by glutamate, aspartate, kynurenine and quinolinic acid in mice].
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glutamates; Glutamic Acid; Grasshoppers; Kynurenine; Male; Membrane Potentials; Mice; Muscles; Pyridines; Quinolinic Acid; Quinolinic Acids; Receptors, Glutamate; Receptors, Neurotransmitter; Seizures | 1986 |
Effect of calcium ions on the sensitivities of cultured cerebellar neurons to glutamate and aspartate.
Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Chick Embryo; Culture Techniques; Drug Interactions; Electric Conductivity; Glutamates; Glutamic Acid; Membrane Potentials; Receptors, Amino Acid; Receptors, Cell Surface | 1986 |
An excitatory amino acid projection from rat prefrontal cortex to periaqueductal gray.
Topics: Animals; Aspartic Acid; Frontal Lobe; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Necrosis; Neurotransmitter Agents; Periaqueductal Gray; Rats; Rats, Inbred Strains; Synaptosomes | 1986 |
Presynaptic, high-affinity glutamate uptake in excitatory neuromuscular junctions of the retractor unguis muscle of the locust: determination of the Km value using high resolution autoradiography.
Topics: Animals; Aspartic Acid; Autoradiography; Glutamates; Glutamic Acid; Grasshoppers; In Vitro Techniques; Kinetics; Motor Neurons; Nerve Endings; Neuroglia; Neuromuscular Junction; Sodium | 1986 |
Amino acid neurotransmitters in the CNS. Characteristics of the acidic amino acid exchange.
Topics: Amino Acids; Amino Acids, Sulfur; Animals; Aspartic Acid; Biological Transport; Brain Chemistry; Cysteic Acid; Cysteine; Glutamates; Glutamic Acid; Kinetics; Neurotransmitter Agents; Rats; Stimulation, Chemical; Synaptosomes | 1986 |
Differential changes in the content of amino acid neurotransmitters in discrete regions of the rat brain prior to the onset and during the course of homocysteine-induced seizures.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Corpus Striatum; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Hippocampus; Homocysteine; Hypothalamus; Inferior Colliculi; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Serine; Substantia Nigra; Taurine; Tissue Distribution | 1986 |
L-glutamate: a neurotransmitter candidate for cone photoreceptors in the monkey retina.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Autoradiography; Glutamates; Glutamic Acid; Histocytochemistry; Kinetics; Macaca fascicularis; Macaca nemestrina; Neurotransmitter Agents; Photoreceptor Cells; Sodium | 1986 |
A magnesium-sensitive post-synaptic potential in rat cerebral cortex resembles neuronal responses to N-methylaspartate.
Topics: Action Potentials; Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Neurons; Rats; Sensory Thresholds; Synapses | 1986 |
Effect of selective kainate lesions on the release of glutamate and aspartate from chick retina.
Topics: Animals; Aspartic Acid; Chickens; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Male; Microinjections; Retina | 1986 |
Comparison of responses to transmitter candidates at an N-methylaspartate receptor mediated synapse, in slices of rat cerebral cortex.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Cysteic Acid; Cysteine; Glutamates; Glutamic Acid; Magnesium; Male; N-Methylaspartate; Neurotransmitter Agents; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission | 1986 |
Ouabain-induced changes in extracellular aspartate, glutamate and GABA levels in the rabbit olfactory bulb in vivo.
Topics: Amino Acids; Animals; Aspartic Acid; Evoked Potentials; Extracellular Space; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Olfactory Bulb; Ouabain; Rabbits; Sodium-Potassium-Exchanging ATPase | 1986 |
Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type.
Topics: Aged; Aging; Alzheimer Disease; Aspartic Acid; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Nerve Tissue Proteins; Osmolar Concentration; Postmortem Changes; Tissue Distribution | 1986 |
The binding of acidic amino acids to snail, Helix aspersa, periesophagic ring membranes reveals a single high-affinity glutamate/kainate site.
Topics: Amino Acids; Animals; Aspartic Acid; Binding Sites; Cysteine; Ganglia; Glutamates; Glutamic Acid; Helix, Snails; Hydrogen-Ion Concentration; In Vitro Techniques; Kainic Acid; Kinetics; Neurotransmitter Agents; Osmolar Concentration | 1986 |
Effects of topically applied excitatory amino acids on evoked potentials and single cell activity in rat cerebral cortex.
Topics: Administration, Topical; Amino Acids; Animals; Aspartic Acid; Carbachol; Cerebral Cortex; Evoked Potentials, Somatosensory; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tetrodotoxin | 1986 |
The effect of testosterone on citrate synthesis and citrate oxidation and a proposed mechanism for regulation of net citrate production in prostate.
Topics: Acetyl Coenzyme A; Animals; Aspartate Aminotransferases; Aspartic Acid; Citrates; Citric Acid; Glutamates; Glutamic Acid; Male; Mitochondria; Models, Biological; Orchiectomy; Oxidation-Reduction; Prostate; Rats; Rats, Inbred Strains; Testis; Testosterone | 1986 |
Effect of 5-amino-4-imidazolecarboxamide riboside on renal ammoniagenesis. Study with [15N]aspartate.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide; Ammonia; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Imidazoles; Kidney; Lactates; Lactic Acid; Male; Models, Biological; Rats; Rats, Inbred Strains; Ribonucleosides | 1986 |
"Desensitization" of excitatory amino acid responses in the rat olfactory cortex.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Concanavalin A; Glutamates; Glutamic Acid; In Vitro Techniques; Ouabain; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1986 |
Responses of amino acids in hindlimb muscles to recovery from hypogravity and unloading by tail-cast suspension.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glutamine; Gravitation; Hindlimb; Muscles; Rats; Weightlessness | 1985 |
[Characteristics of the amino acid spectrum of the blood of children with intellectual deficiency].
Topics: Amino Acids; Ammonia; Arginine; Aspartic Acid; Child; Female; Glutamates; Glutamic Acid; Humans; Intellectual Disability; Male; Movement Disorders; Polyamines; Syndrome; Urea | 1986 |
N-methyl D-aspartate acts as an antagonist of the photoreceptor transmitter in the carp retina.
Topics: Animals; Aspartic Acid; Carps; Glutamates; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neural Inhibition; Neurotransmitter Agents; Photic Stimulation; Photoreceptor Cells; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1986 |
In vivo release of endogenous amino acids from the rat striatum: further evidence for a role of glutamate and aspartate in corticostriatal neurotransmission.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cerebral Cortex; Corpus Striatum; Electric Conductivity; Glutamates; Glutamic Acid; Male; Potassium; Rats; Rats, Inbred Strains; Synaptic Transmission; Tetrodotoxin | 1986 |
Pharmacologically distinct glutamate receptors on cerebellar granule cells.
Topics: 2-Aminoadipic Acid; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1986 |
The effects of continuous superfusion of L-aspartate and L-glutamate on horizontal cells of the turtle retina.
Topics: Animals; Aspartic Acid; Cobalt; Dose-Response Relationship, Drug; Evoked Potentials, Visual; Glutamates; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Neurons; Retina; Turtles | 1986 |
Effects of the phenylalanine-22----leucine, glutamic acid-49----methionine, glycine-234----aspartic acid, and glycine-234----lysine mutations on the folding and stability of the alpha subunit of tryptophan synthase from Escherichia coli.
Topics: Aspartic Acid; Drug Stability; Escherichia coli; Glutamates; Glutamic Acid; Glycine; Kinetics; Leucine; Lysine; Macromolecular Substances; Methionine; Mutation; Phenylalanine; Protein Conformation; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thermodynamics; Tryptophan Synthase | 1986 |
Distribution and stress-induced increase of glutamate and aspartate levels in discrete brain nuclei of rats.
Topics: Animals; Aspartic Acid; Brain Chemistry; Dextroamphetamine; Glutamates; Glutamic Acid; Male; Pain; Rats; Stress, Physiological | 1986 |
Effects of D-aspartate on excitatory amino acid-induced release of [3H]GABA from goldfish retina.
Topics: Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Goldfish; Kainic Acid; Oxadiazoles; Quisqualic Acid; Retina; Tritium | 1986 |
Optic nerve stimulation-induced increase of release of 3H-glutamate and 3H-aspartate but not 3H-GABA from the suprachiasmatic nucleus in slices of rat hypothalamus.
Topics: Animals; Aspartic Acid; Electric Stimulation; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Neurotransmitter Agents; Optic Nerve; Rats; Rats, Inbred Strains; Suprachiasmatic Nucleus; Visual Pathways | 1986 |
Synaptic excitation in cultures of mouse spinal cord neurones: receptor pharmacology and behaviour of synaptic currents.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Glutamates; Glutamic Acid; Mice; Neurons; Pipecolic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Synapses; Time Factors; Valine | 1986 |
A comparative study on the elicitability of vocalization by electrical brain stimulation, glutamate, aspartate and quisqualate in the squirrel monkey.
Topics: Animals; Aspartic Acid; Brain Mapping; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Reaction Time; Saimiri; Vocalization, Animal | 1986 |
Reduced high-affinity glutamate uptake sites in the brains of patients with Huntington's disease.
Topics: Aged; Aspartic Acid; Brain; Caudate Nucleus; Female; Frontal Lobe; Glutamates; Glutamic Acid; Hippocampus; Humans; Huntington Disease; Male; Middle Aged; Paroxetine; Piperidines; Putamen | 1986 |
The presence of N-methyl-D-aspartate-type receptors for glutamic acid in the guinea pig myenteric plexus.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscles; Myenteric Plexus; N-Methylaspartate; Receptors, Glutamate; Receptors, Neurotransmitter | 1986 |
Separation of amino acid and amide nitrogen from plant extracts for 15N analysis.
Topics: Amides; Amino Acids; Ammonia; Asparagine; Aspartic Acid; Chromatography, Ion Exchange; Fabaceae; Glutamates; Glutamic Acid; Glutamine; Nitrogen; Nitrogen Isotopes; Plants; Plants, Medicinal | 1986 |
The occurrence of extended acidic sequences in nonhistone chromosomal proteins.
Topics: Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Cell Nucleus; Chromatography, Gel; Chromosomal Proteins, Non-Histone; Cytoplasm; Glutamates; Glutamic Acid; Liver; Male; Molecular Weight; Peptide Fragments; Peptide Hydrolases; Rats | 1986 |
Biochemical and genetic characterization of L-glutamate transport and utilization in Salmonella typhimurium LT-2 mutants.
Topics: Amino Acid Transport System X-AG; Aspartic Acid; Biological Transport; Genes; Genes, Bacterial; Genotype; Glutamates; Glutamic Acid; Kinetics; Mutation; Phenotype; Salmonella typhimurium; Sodium; Species Specificity | 1986 |
Sites and mechanisms of action of catechol (1,2-dihydroxybenzene) in the rat olfactory cortex slice.
Topics: Action Potentials; Animals; Aspartic Acid; Catechols; Cerebral Cortex; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Neuromuscular Depolarizing Agents; Olfactory Bulb; Potassium; Rats; Rats, Inbred Strains | 1986 |
Role of excitatory amino acid transmission in the genesis of seizures elicited from the deep prepiriform cortex.
Topics: Animals; Aspartic Acid; Bicuculline; Carbachol; Glutamates; Glutamic Acid; Kainic Acid; Limbic System; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Seizures | 1986 |
The purine nucleotide cycle and ammoniagenesis in rat kidney tubules.
Topics: Adenine Nucleotides; Ammonia; Animals; Aspartic Acid; Glucose; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glutamine; Kidney Tubules; Male; Purine Nucleotides; Rats; Rats, Inbred Strains | 1986 |
Amino acid levels in the guinea pig spinal gray matter after axotomy of primary sensory and descending tracts.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Axons; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Nerve Degeneration; Neural Pathways; Neurons, Afferent; Spinal Cord; Spinal Nerve Roots | 1986 |
Na+-dependent "binding" of D-aspartate in brain membranes is largely due to uptake into membrane-bounded saccules.
Topics: Animals; Aspartic Acid; Brain; Carrier Proteins; Cell Membrane; Freezing; Glutamates; Glutamic Acid; Hot Temperature; Kinetics; Osmolar Concentration; Rats; Sodium; Synaptic Membranes | 1986 |
Receptors for excitatory amino acids on neurons in rat pyriform cortex.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Limbic System; N-Methylaspartate; Olfactory Pathways; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Neurotransmitter; Synaptic Transmission | 1986 |
Chemoresponsiveness of intracellular nuclei neurones to L-aspartate, L-glutamate and related derivatives in rat cerebellar slices maintained in vitro.
Topics: Animals; Aspartic Acid; Cerebellar Nuclei; Convulsants; Glutamates; Glutamic Acid; In Vitro Techniques; Injections; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
[Aspartate aminotransferase activity high affinity (3H) glutamate/(3H) aspartate uptake in rat nervous tissue in postnatal development].
Topics: Aging; Animals; Animals, Newborn; Aspartate Aminotransferases; Aspartic Acid; Autoradiography; Ganglia, Spinal; Ganglia, Sympathetic; Glutamates; Glutamic Acid; Hippocampus; Histocytochemistry; Rats; Tritium | 1986 |
Modification of Glu 58, an amino acid of the active center of ribonuclease T1, to Gln and Asp.
Topics: Aspartic Acid; Binding Sites; Endoribonucleases; Escherichia coli; Genes; Genes, Bacterial; Glutamates; Glutamic Acid; Glutamine; Kinetics; Mutation; Phosphorylation; Plasmids; Ribonuclease T1 | 1986 |
Release of endogenous aspartate and glutamate induced by electrical stimulation in guinea pig cerebellar slices.
Topics: Animals; Aspartic Acid; Atropine; Cerebellar Cortex; Cerebellum; Electric Stimulation; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Methysergide; Synaptic Transmission | 1986 |
Non-linear kinetics of glutamyl-tRNA synthesis catalyzed by high molecular weight complexes from rat brain neuronal cells but not from glial cells.
Topics: Acylation; Amino Acyl-tRNA Synthetases; Animals; Aspartic Acid; Brain; Catalysis; Cell Line; Glioma; Glutamates; Glutamic Acid; Glutamine; Kinetics; Macromolecular Substances; Mice; Molecular Weight; Neuroblastoma; Neuroglia; Rats; RNA, Transfer, Amino Acyl; Substrate Specificity; Valine | 1986 |
Comparative actions of quisqualate and N-methyl-D-aspartate, excitatory amino acid agonists, on guinea-pig cochlear potentials.
Topics: Action Potentials; Animals; Aspartic Acid; Cochlea; Dose-Response Relationship, Drug; Evoked Potentials; Glutamates; Glutamic Acid; Guinea Pigs; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Vestibulocochlear Nerve | 1986 |
Transport of cysteate by synaptosomes isolated from rat brain: evidence that it utilizes the same transporter as aspartate, glutamate, and cysteine sulfinate.
Topics: Amino Acids, Sulfur; Animals; Aspartic Acid; Binding, Competitive; Biological Transport; Brain; Carrier Proteins; Chromatography, High Pressure Liquid; Cysteic Acid; Cysteine; Glutamates; Glutamic Acid; Male; Neurotransmitter Agents; Potassium; Rats; Rats, Inbred Strains; Synaptosomes; Veratridine | 1986 |
In vitro release and electrophysiological effects in situ of homocysteic acid, an endogenous N-methyl-(D)-aspartic acid agonist, in the mammalian striatum.
Topics: Animals; Aspartic Acid; Calcium; Cats; Caudate Nucleus; Chromatography, High Pressure Liquid; Corpus Striatum; Drug Synergism; Electric Stimulation; Electrophysiology; Evoked Potentials; Glutamates; Glutamic Acid; Homocysteine; Iontophoresis; Oxadiazoles; Potassium; Quisqualic Acid; Rana temporaria; Rats; Veratrine | 1986 |
Respiratory motoneuronal activity is altered by injections of picomoles of glutamate into cat brain stem.
Topics: Animals; Aspartic Acid; Blood Pressure; Brain Stem; Cats; Dose-Response Relationship, Drug; Electrophysiology; Glutamates; Glutamic Acid; Homocysteine; Microchemistry; Motor Neurons; N-Methylaspartate; Respiration | 1986 |
Characterization of the inhibition of excitatory amino acid-induced neurotransmitter release in the rat striatum by phencyclidine-like drugs.
Topics: Animals; Aspartic Acid; Corpus Striatum; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Neurotransmitter Agents; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1986 |
Reperfusion conditions: critical importance of total ventricular decompression during regional reperfusion.
Topics: Animals; Aspartic Acid; Calcium; Cardiac Catheterization; Coronary Circulation; Coronary Disease; Diltiazem; Dogs; Glutamates; Glutamic Acid; Heart Arrest, Induced; Heart Ventricles; Myocardial Contraction; Potassium Chloride; Tromethamine | 1986 |
Immediate functional recovery after six hours of regional ischemia by careful control of conditions of reperfusion and composition of reperfusate.
Topics: Animals; Aspartic Acid; Calcium; Citrates; Citric Acid; Coronary Circulation; Coronary Disease; Dogs; Glucose; Glutamates; Glutamic Acid; Heart Arrest, Induced; Myocardial Contraction; Oxygen; Phosphates | 1986 |
Early recovery of regional wall motion in patients following surgical revascularization after eight hours of acute coronary occlusion.
Topics: Aspartic Acid; Citrates; Citric Acid; Coronary Circulation; Coronary Disease; Glucose; Glutamates; Glutamic Acid; Heart; Heart Arrest, Induced; Humans; Middle Aged; Myocardial Revascularization; Phosphates; Potassium Chloride; Streptokinase; Tromethamine | 1986 |
Metabolism and transport of amino acids studied by immunocytochemistry.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Hippocampus; Histocytochemistry; Immunochemistry; In Vitro Techniques; Rats; Taurine | 1986 |
Neurons containing NADPH-diaphorase are selectively resistant to quinolinate toxicity.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Humans; Huntington Disease; Kainic Acid; Mice; N-Methylaspartate; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; Neurons; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid | 1986 |
13C n.m.r. study of the structure and the metal ion binding sites of neuropeptides composed of L-Asp and L-Glu.
Topics: Aspartic Acid; Binding Sites; Dipeptides; Glutamates; Glutamic Acid; Magnetic Resonance Spectroscopy; Metals; Neuropeptides; Protein Binding; Protein Conformation; Structure-Activity Relationship | 1986 |
Excitatory amino acid neurotransmitters in the corticostriate pathway: studies using intracerebral microdialysis in vivo.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dialysis; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Male; Neurotransmitter Agents; Rats; Taurine; Threonine | 1986 |
Binding sites for [3H]glutamate and [3H]aspartate in human cerebellum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aspartic Acid; Binding Sites; Calcium Chloride; Cerebellum; Dicarboxylic Acids; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Oxadiazoles; Quisqualic Acid | 1986 |
Glutamic acid as a putative transmitter of the interhemispheric corticocortical connections in the rat.
Topics: Alanine; Animals; Aspartic Acid; Brain Chemistry; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Male; Rats; Rats, Inbred Strains; Serine; Threonine | 1986 |
Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme.
Topics: Alleles; Amino Acid Sequence; Aspartic Acid; Carbohydrate Epimerases; Cells, Cultured; Glutamates; Glutamic Acid; Hot Temperature; Humans; Mutation; Protein Conformation; Triose-Phosphate Isomerase; X-Ray Diffraction | 1986 |
In vivo inhibition of tyrosine uptake into rat retina by large neutral but not acidic amino acids.
Topics: Amino Acids; Amino Acids, Branched-Chain; Animals; Aspartic Acid; Binding, Competitive; Biological Transport; Brain; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Male; Rats; Rats, Inbred Strains; Retina; Tyrosine | 1986 |
The effect of kainic, quinolinic and beta-kainic acids on the release of endogenous amino acids from rat brain slices.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Calcium; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1986 |
Action of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP): a new and highly potent antagonist of N-methyl-D-aspartate receptors in the hippocampus.
Topics: Animals; Aspartic Acid; Cell Membrane; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; N-Methylaspartate; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1986 |
Localization of [3H]glutamate binding sites in rat adrenal medulla.
Topics: Acetates; Acetic Acid; Adrenal Medulla; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cerebral Cortex; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Organ Specificity; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1986 |
Neuromuscular transmission in an insect visceral muscle.
Topics: Animals; Aspartic Acid; Female; Glutamates; Glutamic Acid; Grasshoppers; Membrane Potentials; Muscles; Neuroeffector Junction; Neuropeptides; Octopamine; Oligopeptides; Oviducts; Synaptic Transmission | 1986 |
Heterogeneity of sodium-dependent excitatory amino acid uptake mechanisms in rat brain.
Topics: Animals; Aspartic Acid; Biological Transport, Active; Cerebellum; Cerebral Cortex; Corpus Striatum; Glutamates; Glutamic Acid; Kinetics; Male; Neurotransmitter Uptake Inhibitors; Rats; Rats, Inbred Strains; Sodium; Stereoisomerism; Synaptosomes | 1986 |
Sexual activity alters the concentration of amino acids in the cerebrospinal fluid of male rats.
Topics: Amino Acids; Animals; Aspartic Acid; Ejaculation; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Rats; Rats, Inbred Strains; Sexual Behavior, Animal | 1986 |
Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Autoradiography; Female; Glutamates; Glutamic Acid; Hippocampus; Humans; Kainic Acid; Male; Middle Aged; N-Methylaspartate; Neuronal Plasticity; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission | 1986 |
The uptake and metabolism of L-glutamate by tissue slices of the cestode Hymenolepis diminuta.
Topics: Amino Acids; Animals; Anthelmintics; Aspartic Acid; Biological Transport, Active; Glutamates; Glutamic Acid; Hymenolepis; Kinetics; Neurotransmitter Agents; Ouabain | 1986 |
A postmortem study of amino acid neurotransmitters in Alzheimer's disease.
Topics: Aged; Aging; Alanine; Alzheimer Disease; Amino Acids; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Neurotransmitter Agents; Taurine | 1986 |
Cellular origins of cyclic GMP responses to excitatory amino acid receptor agonists in rat cerebellum in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Drug Interactions; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Nitroprusside; Purkinje Cells; Rats; Tetrodotoxin | 1987 |
Rapid inactivation of brain glutamate decarboxylase by aspartate.
Topics: Animals; Apoenzymes; Aspartic Acid; Brain; Enzyme Reactivators; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Kinetics; Pyridoxal Phosphate; Pyridoxamine; Swine | 1987 |
Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding.
Topics: Alzheimer Disease; Aspartic Acid; Autoradiography; Flunitrazepam; Glutamates; Glutamic Acid; Hippocampus; Histocytochemistry; Humans; Muscimol; N-Methylaspartate; Receptors, GABA-A; Receptors, Muscarinic; Tissue Distribution | 1987 |
Inhibition of excitatory neurotransmission with kynurenate reduces brain edema in neonatal anoxia.
Topics: Animals; Animals, Newborn; Aspartic Acid; Brain Edema; Brain Ischemia; Glutamates; Glutamic Acid; Hypoxia, Brain; Kynurenic Acid; Rats | 1986 |
Analysis of aspartate and glutamate in human cerebrospinal fluid by high-performance liquid chromatography with automated precolumn derivatization.
Topics: Adolescent; Aspartic Acid; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Glutamates; Glutamic Acid; Humans; Infant; Male; Reference Values | 1986 |
Reaction energetics of a mutant triosephosphate isomerase in which the active-site glutamate has been changed to aspartate.
Topics: Aspartic Acid; Binding Sites; Carbohydrate Epimerases; Escherichia coli; Glutamates; Glutamic Acid; Kinetics; Mathematics; Mutation; Thermodynamics; Triose-Phosphate Isomerase; Tritium | 1986 |
[GABA metabolism and the formation of a sensorimotor cortex evoked potential in the presence of excess zinc ions].
Topics: 4-Aminobutyrate Transaminase; Animals; Aspartic Acid; Chlorides; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Motor Cortex; Rabbits; Time Factors; Zinc; Zinc Compounds | 1987 |
Glutamate receptor agonists release [3H]GABA preferentially from horizontal cells.
Topics: Animals; Aspartic Acid; Autoradiography; Chickens; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Rana pipiens; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Retina | 1986 |
Involvement of glutamate in the respiratory metabolism of Bradyrhizobium japonicum bacteroids.
Topics: Aspartic Acid; Carbon Radioisotopes; Glutamates; Glutamic Acid; Kinetics; Malates; Oxygen Consumption; Rhizobiaceae; Succinates; Succinic Acid | 1987 |
In vivo studies on the extracellular, and veratrine-releasable, pools of endogenous amino acids in the rat striatum: effects of corticostriatal deafferentation and kainic acid lesion.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Denervation; Ethanolamines; Extracellular Space; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Male; Rats; Rats, Inbred Strains; Taurine; Veratrine | 1987 |
Cellular origins of endogenous amino acids released into the extracellular fluid of the rat striatum during severe insulin-induced hypoglycemia.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Denervation; Ethanolamines; Extracellular Space; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Hypoglycemia; Insulin; Kainic Acid; Male; Rats; Rats, Inbred Strains; Taurine | 1987 |
The acute effect of ammonium acetate on levels of amino acids in the intact and decorticated rat neostriatum.
Topics: Acetates; Alanine; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Denervation; Frontal Lobe; Glutamates; Glutamic Acid; Glutamine; Rats; Rats, Inbred Strains | 1987 |
Magnesium ions inhibit the stimulation of inositol phospholipid hydrolysis by endogenous excitatory amino acids in primary cultures of cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Drug Synergism; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; Kainic Acid; Magnesium; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Sugar Phosphates; Valine; Veratridine | 1987 |
Effects of high pressure on the release of excitatory amino acids by brain synaptosomes.
Topics: Animals; Aspartic Acid; Central Nervous System Diseases; Cerebral Cortex; Decompression; Glutamates; Glutamic Acid; Guinea Pigs; High Pressure Neurological Syndrome; Kinetics; Male; Neurotransmitter Agents; Synaptosomes; Tritium | 1986 |
Transport of acidic amino acids by human jejunal brush-border membrane vesicles.
Topics: Aspartic Acid; Biological Transport; Glutamates; Glutamic Acid; Humans; Intestinal Mucosa; Jejunum; Kinetics; Leucine; Lysine; Microvilli; Stereoisomerism | 1987 |
Solubilization of novel binding sites for [3H]glutamate in rat adrenal.
Topics: Adrenal Glands; Animals; Aspartic Acid; Detergents; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Solubility | 1987 |
[Regional and time-sequential changes in amino acid neurotransmitters after focal cerebral ischemia in the rat].
Topics: Amino Acids; Animals; Aspartic Acid; Basal Ganglia; Brain; Brain Ischemia; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Substantia Nigra; Time Factors | 1986 |
Engineering of the active site of human lysozyme: conversion of aspartic acid 53 to glutamic acid and tyrosine 63 to tryptophan or phenylalanine.
Topics: Amino Acid Sequence; Aspartic Acid; Chitin; Genetic Engineering; Glutamates; Glutamic Acid; Humans; Micrococcus; Muramidase; Mutation; Phenylalanine; Structure-Activity Relationship; Substrate Specificity; Tryptophan; Tyrosine | 1987 |
Biochemical evidence for glutamate and/or aspartate as neurotransmitters in fibers from the visual cortex to the lateral posterior thalamic nucleus (pulvinar) in rats.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Male; Nerve Fibers; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Thalamic Nuclei; Visual Cortex | 1987 |
Electrophysiological and pharmacological actions of N-acetylaspartylglutamate intracellularly studied in cultured chick cerebellar neurons.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Cell Membrane; Cells, Cultured; Cerebellum; Chick Embryo; Dipeptides; Electric Conductivity; Glutamates; Glutamic Acid; Magnesium | 1987 |
Synthesis of glutamate and aspartate in rat brain synaptosomes.
Topics: Adenosine Triphosphate; Ammonia; Animals; Aspartic Acid; Brain; Citrates; Citric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Synaptosomes | 1986 |
Aortic baroreceptor reflexes are mediated by NMDA receptors in caudal ventrolateral medulla.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aorta; Aspartic Acid; Electric Stimulation; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Injections, Intraventricular; Medulla Oblongata; Microinjections; N-Methylaspartate; Pressoreceptors; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex; Synaptic Transmission; Valine | 1987 |
Multiple Cl(-)-independent binding sites for the excitatory amino acids: glutamate, aspartate and cysteine sulfinate in rat brain membranes.
Topics: Animals; Aspartic Acid; Brain; Chlorides; Cysteine; Glutamates; Glutamic Acid; Kinetics; Male; Membranes; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Sodium; Synaptic Membranes | 1987 |
Toxicology of tremorgenic mycotoxins, fumitremorgin A and B.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Chlorpromazine; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Haloperidol; Harmine; Indenes; Indoles; Lethal Dose 50; Male; Mice; Perphenazine; Posture; Reserpine; Seizures; Spiperone; Triflupromazine | 1986 |
Comparison of L-[3H]glutamate, D-[3H]aspartate, DL-[3H]AP5 and [3H]NMDA as ligands for NMDA receptors in crude postsynaptic densities from rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Brain; Brain Chemistry; Chemical Phenomena; Chemistry; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1987 |
Amino acid neurotransmitters in the CNS. Relationships between net uptake and exchange in rat brain synaptosomes.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Kinetics; Male; Neurotransmitter Agents; Potassium; Rats; Rats, Inbred Strains; Sodium; Synaptosomes | 1987 |
Effect of free malonate on the utilization of glutamate by rat brain mitochondria.
Topics: Animals; Aspartic Acid; Brain; Citric Acid Cycle; Female; Glutamates; Glutamic Acid; Ketoglutaric Acids; Male; Malonates; Mitochondria; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Rats | 1987 |
Glutamate deficits in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Humans; Middle Aged | 1987 |
CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.
Topics: Acetylcholine; Animals; Aspartic Acid; Cerebellum; Corpus Striatum; Cyclic GMP; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1987 |
Effects of glutaminase inhibition on release of endogenous glutamic acid.
Topics: 2-Chloroadenosine; Adenosine; Amygdala; Animals; Aspartic Acid; Diazooxonorleucine; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutaminase; Glycine; Haloperidol; In Vitro Techniques; Rats; Serotonin; Synaptosomes | 1986 |
Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by D(-)aminophosphonovalerate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Depression, Chemical; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Male; Rats; Rats, Inbred Strains; Synaptic Transmission; Valine | 1987 |
Region-specific loss of glutamate innervation in Alzheimer's disease.
Topics: Alzheimer Disease; Aspartic Acid; Brain; Cerebral Cortex; Glutamates; Glutamic Acid; Hippocampus; Humans; Synaptosomes | 1987 |
Excitatory amino acids increase glycogen phosphorylase activity in the rat spinal cord.
Topics: Animals; Aspartic Acid; Bucladesine; Cyclic AMP; Decerebrate State; Enzyme Activation; Glutamates; Glutamic Acid; Injections, Spinal; Phosphorylases; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord | 1987 |
Subchronic haloperidol and sulpiride treatment induces region-specific changes in tissue levels of putative amino acid transmitters in rat brain.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Haloperidol; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Sulpiride | 1987 |
Enhancement of [3H]glutamate binding by N-methyl-D-aspartic acid in rat adrenal.
Topics: Adrenal Glands; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Male; Membranes; Molecular Conformation; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium; Stimulation, Chemical | 1987 |
Identification and characterization of an N-methyl-D-aspartate-specific L-[3H]glutamate recognition site in synaptic plasma membranes.
Topics: Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Ions; Kinetics; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptic Membranes; Temperature; Time Factors | 1987 |
High-affinity transport of gamma-aminobutyric acid, glycine, taurine, L-aspartic acid, and L-glutamic acid in synaptosomal (P2) tissue: a kinetic and substrate specificity analysis.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport; Brain Stem; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Kinetics; Mice; Mice, Inbred BALB C; Neurotransmitter Agents; Spinal Cord; Substrate Specificity; Synaptosomes; Taurine | 1987 |
The dementia of Alzheimer's disease: an update.
Topics: Afferent Pathways; Alzheimer Disease; Amygdala; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Male; Rats; Rats, Inbred Strains; Substantia Innominata | 1987 |
[Effects of aspartic acid in the electroreceptors of the skate].
Topics: Action Potentials; Animals; Aspartic Acid; Electric Fish; Glutamates; Glutamic Acid; Sense Organs; Sensory Receptor Cells; Skates, Fish; Synapses; Synaptic Transmission | 1987 |
Changes in neurotransmitter amino acids content in several CNS areas from aggressive and non-aggressive bull strains.
Topics: Aggression; Amino Acids; Animals; Aspartic Acid; Brain Stem; Cattle; Cerebellum; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Mesencephalon; Pons; Synaptosomes | 1987 |
Cytoplasmic calcium elevation in hippocampal granule cell induced by perforant path stimulation and L-glutamate application.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Anticonvulsants; Aspartic Acid; Benzofurans; Calcium; Cytoplasm; Egtazic Acid; Electric Stimulation; Fluorescent Dyes; Fura-2; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neural Pathways; Tetrodotoxin; Valine | 1987 |
Immunohistochemical visualization of glutamate- and aspartate-containing nerve terminal pools in the rat limbic structures.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hippocampus; Immune Sera; Immunoenzyme Techniques; Limbic System; Male; Olfactory Bulb; Rats; Synapses | 1987 |
Effect of transient neonatal hypothyroidism on the free aspartic acid, glutamic acid, and GABA content of different central auditory regions in the rat.
Topics: Animals; Animals, Newborn; Aspartic Acid; Auditory Cortex; Cochlea; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hearing; Hypothyroidism; Inferior Colliculi; Male; Rats; Substantia Nigra | 1987 |
Sources of presumptive glutamergic/aspartergic afferents to the rat ventral striatopallidal region.
Topics: Animals; Aspartic Acid; Autoradiography; Brain Stem; Corpus Striatum; Diencephalon; Glutamates; Glutamic Acid; Neural Pathways; Olfactory Bulb; Rats; Telencephalon | 1987 |
The effects of prolonged superfusions with acidic amino acids and their agonists on field potentials and horizontal cell photoresponses in the turtle retina.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Perfusion; Photoreceptor Cells; Retina; Turtles | 1987 |
Amino acid neurotransmitters in postmortem human brain analyzed by high performance liquid chromatography with electrochemical detection.
Topics: Aged; Alanine; Amino Acids; Aspartic Acid; Brain; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Neurotransmitter Agents; Taurine; Tissue Distribution | 1987 |
Elevated glutamic acid values in a malnourished patient. A case report.
Topics: Ammonia; Aspartic Acid; Ethanolamines; Female; Glutamates; Glutamic Acid; Humans; Middle Aged; Nutrition Disorders; Pellagra; Proline; Urea | 1987 |
Metabolic fate of glutamate carbon in rat renal tubules. Studies with 13C nuclear magnetic resonance and gas chromatography-mass spectrometry.
Topics: Acidosis, Renal Tubular; Ammonia; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Glucose; Glutamates; Glutamic Acid; In Vitro Techniques; Kidney Tubules; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred Strains | 1987 |
Stereospecific labilization of the C-4' pro-S hydrogen of pyridoxamine 5'-phosphate in aspartate aminotransferase. Activators and inhibitors.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Borohydrides; Chickens; Glutamates; Glutamic Acid; Kinetics; Mitochondria, Heart; Protein Conformation; Pyridoxamine; Stereoisomerism; Structure-Activity Relationship | 1987 |
Joro spider venom: glutamate agonist and antagonist on the rod retina of the dogfish.
Topics: Animals; Arthropod Venoms; Aspartic Acid; Dogfish; Glutamates; Glutamic Acid; Iontophoresis; Kainic Acid; Photic Stimulation; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Spider Venoms; Spiders | 1987 |
The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes; Valine | 1987 |
Evidence for a direct action of N-methylaspartate on non-neuronal cells.
Topics: Amino Acids; Animals; Aspartic Acid; Cell Survival; Dialysis; Ethanolamines; Extracellular Space; Glutamates; Glutamic Acid; Glutamine; Hippocampus; Male; N-Methylaspartate; Neuroglia; Purines; Rats; Rats, Inbred Strains; Taurine | 1987 |
Amino acid changes in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy.
Topics: Aged; Amino Acids; Aspartic Acid; Brain Chemistry; Chromatography, High Pressure Liquid; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male; Middle Aged | 1987 |
Glutamatergic denervation in Alzheimer's disease--a cautionary note.
Topics: Alzheimer Disease; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Humans; Nerve Degeneration | 1987 |
[Analysis of the effect of glutamic acid diethyl ester on synaptic processes in the ampullae of Lorenzini of the skate].
Topics: Animals; Aspartic Acid; Depression, Chemical; Electric Fish; Electricity; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; Sense Organs; Sensory Receptor Cells; Skates, Fish; Synapses; Synaptic Transmission | 1987 |
Features of amino acid metabolism in Moniliformis moniliformis (Acanthocephala) in vitro.
Topics: Acanthocephala; Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glycine; Moniliformis; Rats | 1987 |
Increase in [3H]glutamate release from slices of dentate gyrus and hippocampus following classical conditioning in the rat.
Topics: Animals; Aspartic Acid; Calcium; Conditioning, Classical; Conditioning, Operant; Glutamates; Glutamic Acid; Hippocampus; Male; Potassium; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission | 1987 |
Effects of preformed proline and proline amino acid precursors (including glutamine) on collagen synthesis in human fibroblast cultures.
Topics: Amino Acids; Aspartic Acid; Cells, Cultured; Fibroblasts; Glutamates; Glutamic Acid; Glutamine; Humans; Hydroxyproline; Ornithine; Procollagen; Proline; Pyrrolidonecarboxylic Acid; RNA, Transfer, Amino Acyl | 1987 |
In vivo and in vitro adenosine stimulation of ethanol oxidation by hepatocytes, and the role of the malate-aspartate shuttle.
Topics: Adenosine; Animals; Aspartic Acid; Ethanol; Glutamates; Glutamic Acid; In Vitro Techniques; Liver; Malates; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1987 |
Characterization of quisqualate-type L-glutamate receptors in the retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic Acid; Binding, Competitive; Chickens; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Ibotenic Acid; Kinetics; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Subcellular Fractions | 1987 |
Postnatal development of the chemosensitivity of rat cerebellar Purkinje cells to excitatory amino acids. An in vitro study.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cerebellar Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Reaction Time; Valine | 1987 |
A comparative study and partial characterization of multi-uptake systems for gamma-aminobutyric acid.
Topics: Animals; Aspartic Acid; Biological Transport, Active; Brain; Cerebral Cortex; Cricetinae; Diencephalon; Dogs; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Kinetics; Male; Mesencephalon; Mice; Olfactory Bulb; Rats; Rats, Inbred Strains; Species Specificity; Synaptosomes | 1987 |
Ammonia-induced release of neurotransmitters from rat brain synaptosomes: differences between the effects on amines and amino acids.
Topics: Amines; Amino Acids; Ammonium Chloride; Animals; Aspartic Acid; Benztropine; Brain; Calcium; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Male; Membrane Potentials; Neurotransmitter Agents; Potassium; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes | 1987 |
Excitatory amino acid receptor potency and subclass specificity of sulfur-containing amino acids.
Topics: Amino Acids, Sulfur; Aminobutyrates; Animals; Aspartic Acid; Brain; Chick Embryo; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Sodium; Synaptic Membranes | 1987 |
Redistribution of transmitter amino acids in rat hippocampus and cerebellum during seizures induced by L-allylglycine and bicuculline: an immunocytochemical study with antisera against conjugated GABA, glutamate and aspartate.
Topics: Allylglycine; Animals; Aspartic Acid; Bicuculline; Cerebellum; Epilepsy; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Hippocampus; Immunoenzyme Techniques; Male; Neurons; Rats; Rats, Inbred Strains; Synaptic Transmission | 1987 |
Extracellular overflow of glutamate, aspartate, GABA and taurine in the cortex and basal ganglia of fetal lambs during hypoxia-ischemia.
Topics: Amino Acids; Animals; Aspartic Acid; Asphyxia; Brain Ischemia; Cerebrovascular Circulation; Evoked Potentials, Somatosensory; Fetus; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hypoxia, Brain; Sheep; Taurine; Telencephalon | 1987 |
Neurotransmitter amino acids in epilepsy.
Topics: Amino Acids; Aspartic Acid; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Neurotransmitter Agents; Receptors, GABA-A; Receptors, Neurotransmitter | 1987 |
Ischemic heart arrest: nitrogenous metabolism in energy-depleted human myocardium.
Topics: Adenosine Triphosphate; Alanine; Ammonia; Aspartic Acid; Energy Metabolism; Glutamates; Glutamic Acid; Heart Arrest, Induced; Heart Septal Defects, Ventricular; Humans; Myocardium; Nitrogen; Tetralogy of Fallot | 1987 |
Localization of glutamate, glutaminase, aspartate and aspartate aminotransferase in the rat midbrain periaqueductal gray.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Glutamates; Glutamic Acid; Glutaminase; Immunohistochemistry; Male; Mesencephalon; Neurons; Periaqueductal Gray; Rats; Rats, Inbred Strains | 1987 |
L-glutamate and N-methyl-D-asparatate actions on membrane potential and conductance of cat abducens motoneurones.
Topics: Abducens Nerve; Action Potentials; Animals; Aspartic Acid; Cats; Electric Conductivity; Glutamates; Glutamic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neural Conduction | 1987 |
Determination of delta-aminobutyric acid and other amino acids in cerebrospinal fluid of pediatric patients by reversed-phase liquid chromatography.
Topics: Amino Acids; Aspartic Acid; Child; Child, Preschool; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Humans; Infant; Myelography; Neurotransmitter Agents; Reference Standards | 1987 |
Accumulation of free amino acids in growing Xenopus laevis oocytes.
Topics: Amino Acids; Animals; Aspartic Acid; Female; Glutamates; Glutamic Acid; Oocytes; Protein Biosynthesis; Xenopus laevis | 1987 |
Exotoxin A of Pseudomonas aeruginosa: substitution of glutamic acid 553 with aspartic acid drastically reduces toxicity and enzymatic activity.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; Aspartic Acid; Bacterial Toxins; Cell Survival; Cloning, Molecular; Escherichia coli; Exotoxins; Glutamates; Glutamic Acid; L Cells; Mice; Mutation; Pentosyltransferases; Plasmids; Pseudomonas aeruginosa; Pseudomonas aeruginosa Exotoxin A; Virulence Factors | 1987 |
In vivo microdialysis studies on the effects of decortication and excitotoxic lesions on kainic acid-induced calcium fluxes, and endogenous amino acid release, in the rat striatum.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Calcium Radioisotopes; Cerebral Cortex; Corpus Striatum; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Male; Neurons; Phosphatidylethanolamines; Rats; Rats, Inbred Strains; Taurine | 1987 |
[3H]norepinephrine release from hippocampal slices is an in vitro biochemical tool for investigating the pharmacological properties of excitatory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Tetrodotoxin | 1987 |
Formation and utilization of the active sulfate donor [35S]3'-phosphoadenosine 5'-phosphosulfate in brain slices: effects of depolarizing agents.
Topics: Adenine Nucleotides; Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; Kinetics; Male; Naphthols; Nitrophenols; Oxadiazoles; Phosphoadenosine Phosphosulfate; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Sulfates; Sulfur Radioisotopes; Veratridine; Veratrine | 1987 |
Immunohistochemistry and biosynthesis of N-acetylaspartylglutamate in spinal sensory ganglia.
Topics: Amino Acids; Animals; Anisomycin; Aspartic Acid; Chromatography, High Pressure Liquid; Cycloheximide; Dipeptides; Ganglia; Ganglia, Spinal; Glutamates; Glutamic Acid; Glutamine; Histocytochemistry; Immunologic Techniques; Male; Neurons; Rats; Rats, Inbred Strains | 1987 |
Neuronal uptake and laminar distribution of tritiated aspartate, glutamate, gamma-aminobutyrate and glycine in the prestriate cortex of squirrel monkeys: correlation with levels of cytochrome oxidase activity and their uptake in area 17.
Topics: Amino Acids; Animals; Aspartic Acid; Electron Transport Complex IV; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Neuroglia; Neurons; Saimiri; Tissue Distribution; Tritium; Visual Cortex | 1987 |
Hippocampal cells primed with quisqualate are depolarized by AP4 and AP6, ligands for a putative glutamate uptake site.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Aminocaproates; Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Norleucine; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1987 |
Voltage-dependency of the responses of cerebellar Purkinje cells to excitatory amino acids.
Topics: Action Potentials; Animals; Aspartic Acid; Cadmium; Glutamates; Glutamic Acid; Membrane Potentials; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Tetrodotoxin | 1987 |
Glutamate-induced ionic currents in cultured neurons from the rat superior colliculus.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Glutamates; Glutamic Acid; Magnesium; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Superior Colliculi | 1987 |
Glutamate receptor subtypes in cultured cerebellar neurons: modulation of glutamate and gamma-aminobutyric acid release.
Topics: Animals; Aspartic Acid; Calcium; Cations; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium | 1987 |
Ubiquitin-directed antibodies inhibit neuronal transporters in rat brain synaptosomes.
Topics: Animals; Antibodies; Aspartic Acid; Biological Transport; Brain; Carrier Proteins; Cell Membrane; Choline; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Sodium; Synaptosomes; Ubiquitins | 1987 |
Amino acid influences on seizures elicited within the inferior colliculus.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Inferior Colliculi; Male; Muscimol; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Taurine | 1987 |
Autoradiographic localization of cerebellar excitatory amino acid binding sites in the mouse.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Cerebellum; Glutamates; Glutamic Acid; Kainic Acid; Mice; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface | 1987 |
Reversal potentials of rod horizontal cell responses in the carp retina.
Topics: Action Potentials; Animals; Aspartic Acid; Calcium; Carps; Cyprinidae; Glutamates; Glutamic Acid; Membrane Potentials; Photic Stimulation; Retina | 1987 |
Lesions of putative glutamatergic pathways potentiate the increase of inositol phospholipid hydrolysis elicited by excitatory amino acids.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Colchicine; Corpus Striatum; Glutamates; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1987 |
L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor.
Topics: Animals; Aspartic Acid; Binding, Competitive; Brain; Chick Embryo; Glutamates; Glutamic Acid; Homocysteine; Kainic Acid; Ligands; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1987 |
Characterization of antisera to glutamate and aspartate.
Topics: Animals; Antibody Specificity; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Ganglia, Spinal; Glutamates; Glutamic Acid; Glutaral; Hemocyanins; Immune Sera; Immunoenzyme Techniques; Immunosorbent Techniques; Rats; Somatosensory Cortex | 1988 |
D-aspartate uptake and release in the guinea pig spinal cord after partial ablation of the cerebral cortex.
Topics: Animals; Aspartic Acid; Calcium; Cerebral Cortex; Electric Stimulation; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Parietal Lobe; Spinal Cord; Synapses | 1988 |
Changes in the relative amounts of aspartate and glutamate released and retained in hippocampal slices during stimulation.
Topics: Action Potentials; Animals; Aspartic Acid; Calcium; Electric Stimulation; Glucose; Glutamates; Glutamic Acid; Hippocampus; Kinetics; Rats; Tetrodotoxin | 1988 |
Glutamate transport in large muscle fibres of Balanus nubilus.
Topics: Animals; Aspartic Acid; Binding, Competitive; Biological Transport; Carbon Radioisotopes; Cysteic Acid; Diffusion; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Kinetics; Muscles; Sodium; Thoracica | 1988 |
Potentiation by kainate of excitatory amino acid release in striatum: complementary in vivo and in vitro experiments.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Corpus Striatum; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Potassium; Rats; Rats, Inbred Strains; Taurine; Tetrodotoxin | 1988 |
Cytotoxic properties of glutamate and aspartate in rat peripheral nerves: histological findings.
Topics: Animals; Aspartic Acid; Female; Glutamates; Glutamic Acid; Male; Nerve Degeneration; Rats; Rats, Inbred Strains; Sciatic Nerve | 1987 |
L-homocysteic acid but not L-glutamate is an endogenous N-methyl-D-aspartic acid receptor preferring agonist in rat neocortical neurons in vitro.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Bidirectional transfer between kindling induced by excitatory amino acids and electrical stimulation.
Topics: Amygdala; Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; Injections; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains | 1987 |
The laminar distribution of amino acids in the caudal cerebellum and electrosensory lateral line lobe of weakly electric fish (Gymnotidae).
Topics: Amino Acids; Animals; Aspartic Acid; beta-Alanine; Cerebellum; Electric Fish; Electric Organ; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Taurine | 1987 |
Glutamate suppression of feeding and the underlying output of effector neurons in Helisoma.
Topics: Amino Acids; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Feeding Behavior; Glutamates; Glutamic Acid; Ions; Iontophoresis; Motor Activity; Neurons; Osmolar Concentration; Seawater; Snails; Sodium | 1987 |
Kainic acid inhibits the synaptosomal plasma membrane glutamate carrier and allows glutamate leakage from the cytoplasm but does not affect glutamate exocytosis.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Calcium; Carrier Proteins; Cell Membrane; Cytoplasm; Exocytosis; Female; Glutamate Dehydrogenase; Glutamate Plasma Membrane Transport Proteins; Glutamates; Glutamic Acid; Guinea Pigs; Kainic Acid; Male; Permeability; Symporters; Synaptosomes | 1988 |
Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Oxadiazoles; Quisqualic Acid; Valine | 1988 |
Long-lasting potentiation produced by a phorbol ester in the hippocampus of the anaesthetized rat is not associated with a persistent enhanced release of excitatory amino acids.
Topics: Action Potentials; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hippocampus; Phorbol Esters; Rats; Rats, Inbred Strains; Time Factors | 1987 |
Continuous glutamate leakage from brain cells is balanced by compensatory high-affinity reuptake transport.
Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Tetrodotoxin | 1987 |
Synaptic transmission between rat cerebellar granule and Purkinje cells in dissociated cell culture: effects of excitatory-amino acid transmitter antagonists.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aspartic Acid; Cells, Cultured; Cerebellum; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenic Acid; Purkinje Cells; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission; Tetrodotoxin; Valine | 1988 |
Significance of the alanine aminotransferase reaction in the formation of alpha-ketoglutarate in rat liver mitochondria.
Topics: Alanine; Alanine Transaminase; Animals; Aspartic Acid; Citrates; Citric Acid; Glutamates; Glutamic Acid; Ketoglutaric Acids; Malates; Male; Mitochondria, Liver; Oxaloacetates; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1988 |
Differential effects of serotonin on the spontaneous discharge and on the excitatory amino acid-induced responses of deep cerebellar nuclei neurons in rat cerebellar slices.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; Calcium; Cerebellar Nuclei; Drug Interactions; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Serotonin | 1987 |
Increases in striatal and hippocampal impedance and extracellular levels of amino acids by cardiac arrest in freely moving rats.
Topics: Amino Acids; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Electrophysiology; Extracellular Space; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Heart Arrest; Hippocampus; Kinetics; Male; Rats; Rats, Inbred Strains; Taurine | 1988 |
Regulation of transmitter gamma-aminobutyric acid (GABA) synthesis and metabolism illustrated by the effect of gamma-vinyl GABA and hypoglycemia.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Aspartic Acid; Corpus Striatum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Hypoglycemia; Male; Postmortem Changes; Rats; Rats, Inbred Strains; Vigabatrin | 1988 |
A novel superfusion chamber for the measurement of endogenous glutamate release from cerebellar slices.
Topics: Animals; Aspartic Acid; Cerebellum; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; In Vitro Techniques; Perfusion; Potassium | 1988 |
Huntington's disease: studies on brain free amino acids.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Aspartic Acid; Brain; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Histidine; Humans; Huntington Disease; Lysine; Male; Middle Aged; Putamen; Serine; Taurine | 1988 |
An immunogenic region within residues Val1670-Glu1684 of the factor VIII light chain induces antibodies which inhibit binding of factor VIII to von Willebrand factor.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antibody Specificity; Aspartic Acid; Binding Sites; Factor VIII; Glutamates; Glutamic Acid; Isoleucine; Valine; von Willebrand Factor | 1988 |
Fictive locomotion in the lamprey; a comparison using bicarbonate and HEPES buffers.
Topics: Animals; Aspartic Acid; Bicarbonates; Buffers; Fishes; Glutamates; Glutamic Acid; HEPES; Lampreys; Locomotion; N-Methylaspartate; Spinal Cord | 1988 |
Endogenous ligands for the quisqualate receptor: presence in rat brain cortex synaptic vesicles.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Vesicles; Synaptosomes | 1988 |
Microdialysis measurement of oxytocin, aspartate, gamma-aminobutyric acid and glutamate release from the olfactory bulb of the sheep during vaginocervical stimulation.
Topics: Animals; Aspartic Acid; Cervix Uteri; Dialysis; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Olfactory Bulb; Oxytocin; Sheep; Vagina | 1988 |
L-glutamate evoked release of GABA from cultured avian retina cells does not require glutamate receptor activation.
Topics: Acetylcholine; Animals; Aspartic Acid; Calcium; Cells, Cultured; Chick Embryo; Chlorides; Choline; Cobalt; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kinetics; Lithium; Lithium Chloride; Magnesium; Receptors, Glutamate; Receptors, Neurotransmitter; Retina | 1988 |
Excitatory amino acid-evoked membrane currents and excitatory synaptic transmission in lamprey reticulospinal neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Stem; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Lampreys; N-Methylaspartate; Neurons; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Spinal Cord; Synapses; Synaptic Transmission | 1988 |
Utilization of the synthetic phosphagen cyclocreatine phosphate by a simple brain model during stimulation by neuroexcitatory amino acids.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Chick Embryo; Glutamates; Glutamic Acid; Homocysteine; Imidazolidines; Kainic Acid; Magnesium; N-Methylaspartate; Phosphocreatine | 1988 |
Enhancement of the oxygen consumption in the hippocampal slices of the guinea pig induced by glutamate and its related substances.
Topics: Action Potentials; Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxygen Consumption | 1988 |
Changes in the state of the excitatory synaptic system in the hippocampus on prolonged exposure to excitatory amino acids and antagonists.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Action Potentials; Animals; Aspartic Acid; Dipeptides; Female; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission; Valine | 1988 |
Presynaptic and postsynaptic glutamatergic function in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Female; Glutamates; Glutamic Acid; Humans; Male; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Temporal Lobe | 1988 |
Presence of D-aspartate oxidase in rat liver and mouse tissues.
Topics: Amino Acid Oxidoreductases; Animals; Aspartic Acid; D-Aspartate Oxidase; Flavin-Adenine Dinucleotide; Glutamates; Glutamic Acid; Kinetics; Liver; Male; Mice; Mice, Inbred ICR; Oxaloacetates; Oxygen; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Tissue Distribution | 1988 |
Ventricular cerebrospinal fluid concentrations of putative amino acid transmitters in Parkinson's disease and other disorders.
Topics: Adult; Aged; Amino Acids; Aspartic Acid; Ethanolamine; Ethanolamines; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Neurotransmitter Agents; Parkinson Disease; Proline; Tremor | 1987 |
Determination of amino acids in different regions of the rat brain. Application to the acute effects of tetrahydrocannabinol (THC) and trimethyltin (TMT).
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Dronabinol; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Male; Quality Control; Rats; Rats, Inbred Strains; Taurine; Tissue Distribution; Trialkyltin Compounds; Trimethyltin Compounds | 1988 |
Increase in the stimulation-induced overflow of excitatory amino acids from hippocampal slices: interaction between low glucose concentration and fluoroacetate.
Topics: Animals; Aspartic Acid; Electric Stimulation; Fluoroacetates; Glucose; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Rats; Time Factors | 1988 |
gamma-L-glutamyl-L-aspartate induces specific deficits in long-term memory and inhibits [3H]glutamate binding on hippocampal membranes.
Topics: Amino Acids; Animals; Aspartic Acid; Avoidance Learning; Cell Membrane; Dipeptides; Emotions; Glutamates; Glutamic Acid; Hippocampus; Kinetics; Male; Memory; Mice; Receptors, Glutamate; Receptors, Neurotransmitter; Reference Values; Time Factors | 1988 |
Effects of noradrenaline on the responsiveness of cultured cerebellar neurons to excitatory amino acids.
Topics: Action Potentials; Animals; Aspartic Acid; Cell Count; Cells, Cultured; Cerebellum; Chick Embryo; Cyclic AMP; Glutamates; Glutamic Acid; Membrane Potentials; Norepinephrine; Phentolamine; Pindolol; Propranolol; Purkinje Cells | 1988 |
The modulation of excitatory amino acid responses by serotonin in the cat neocortex in vitro.
Topics: Animals; Aspartic Acid; Cats; Cerebral Cortex; Cinanserin; Electric Stimulation; Evoked Potentials; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; Membrane Potentials; Methysergide; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Serotonin; Tetraethylammonium Compounds; Tetrodotoxin | 1987 |
Extracellular amino acid concentrations in the dorsal spinal cord of freely moving rats following veratridine and nociceptive stimulation.
Topics: Amino Acids; Animals; Aspartic Acid; Dialysis; Extracellular Space; Formaldehyde; Glutamates; Glutamic Acid; Male; Nociceptors; Rats; Rats, Inbred Strains; Spinal Cord; Tetrodotoxin; Veratridine; Veratrine | 1988 |
Solubilization of rat brain phencyclidine receptors in an active binding form that is sensitive to N-methyl-D-aspartate receptor ligands.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Brain Chemistry; Cell Membrane; Cholic Acid; Cholic Acids; Detergents; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Solubility; Valine | 1988 |
Inhibition by forskolin of excitatory amino acid-induced accumulation of cyclic AMP in guinea pig hippocampal slices.
Topics: Adenosine; Amino Acids; Animals; Aspartic Acid; Chlorides; Colforsin; Cyclic AMP; Cysteine; Drug Interactions; Ethylmaleimide; Glutamates; Glutamic Acid; Guanosine Triphosphate; Guinea Pigs; Hippocampus; Histamine; Male; N-Methylaspartate; Neurotransmitter Agents; Veratridine | 1988 |
Evidence that aspartate aminotransferase activity and ketodicarboxylate carrier function are essential for biosynthesis of transmitter glutamate.
Topics: Aminooxyacetic Acid; Animals; Aspartate Aminotransferases; Aspartic Acid; Calcium Chloride; Carrier Proteins; Cells, Cultured; Cerebellum; Cobalt; Glutamates; Glutamic Acid; Glutamine; Mice; Succinates | 1988 |
Aspartic acid aminotransferase activity is increased in actively spiking compared with non-spiking human epileptic cortex.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Aspartic Acid; Biopsy; Cerebral Cortex; Epilepsies, Partial; Epilepsy, Temporal Lobe; Evoked Potentials; Female; Glutamates; Glutamic Acid; Humans; Male; Middle Aged | 1988 |
Effect of depolarization on the maturation of cerebellar granule cells in culture.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Potassium; Rats; Tetrodotoxin; Time Factors; Veratridine; Veratrine | 1988 |
Release of neurotransmitter amino acids from rat brain synaptosomes and its regulation in aging.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Brain; Calcium; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Neurotransmitter Agents; Potassium; Rats; Synaptosomes | 1988 |
Comparison of primary afferent and glutamate excitation of neurons in the mammalian spinal dorsal horn.
Topics: Afferent Pathways; Amino Acids; Animals; Aspartic Acid; Cricetinae; Dipeptides; Electrophoresis; Glutamates; Glutamic Acid; Male; Mesocricetus; Neurons; Spinal Cord | 1988 |
Kinetic studies of chicken and turkey liver mitochondrial aspartate aminotransferase.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Chickens; Glutamates; Glutamic Acid; Ketoglutaric Acids; Kinetics; Mitochondria, Liver; Models, Biological; Turkeys | 1988 |
Excitatory amino acid antagonists and endogenous aspartate and glutamate release from rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Tetrodotoxin; Valine | 1988 |
Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.
Topics: Animals; Asparagine; Aspartic Acid; Cell Membrane; Epinephrine; Glutamates; Glutamic Acid; Isoproterenol; Kinetics; L Cells; Mice; Mutation; Receptors, Adrenergic, beta; Structure-Activity Relationship | 1988 |
CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist.
Topics: Acetylcholine; Aconitine; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Binding, Competitive; Darkness; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Structure-Activity Relationship; Tetrodotoxin | 1988 |
L-glutamate-induced depolarization in solitary photoreceptors: a process that may contribute to the interaction between photoreceptors in situ.
Topics: Animals; Aspartic Acid; Axons; Dose-Response Relationship, Drug; Electric Conductivity; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Photoreceptor Cells; Quisqualic Acid; Sodium; Turtles | 1988 |
Ca2+-dependent activation of the malate-aspartate shuttle by norepinephrine and vasopressin in perfused rat liver.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Calcimycin; Calcium; Ethanol; Glucose; Glutamates; Glutamic Acid; Ketoglutaric Acids; Liver; Malates; Male; Norepinephrine; Perfusion; Rats; Rats, Inbred Strains; Sorbitol; Vasopressins | 1988 |
Sites of action of glucagon and other Ca2+ mobilizing hormones on the malate aspartate cycle.
Topics: Animals; Aspartic Acid; Binding Sites; Calcium; Glucagon; Glutamates; Glutamic Acid; Intracellular Membranes; Ketoglutaric Acids; Malates; Mitochondria, Liver; Onium Compounds; Organophosphorus Compounds; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1988 |
Influence of total nitrogen, asparagine, and glutamine on MCA tumor growth in the Fischer 344 rat.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Body Weight; Glutamates; Glutamic Acid; Glutamine; Male; Nitrogen; Organ Size; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental | 1988 |
Reaction mechanism of the reconstituted aspartate/glutamate carrier from bovine heart mitochondria.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Binding, Competitive; Biological Transport; Carrier Proteins; Cattle; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Liposomes; Membrane Potentials; Mitochondria; Myocardium | 1988 |
Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Caudate Nucleus; Cerebral Cortex; Female; Glutamates; Glutamic Acid; Hippocampus; Humans; Kinetics; Male; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
High-affinity uptake of L-[3H]glutamate and D-[3H]aspartate during postnatal development of the hippocampal formation: a quantitative autoradiographic study.
Topics: Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Glutamates; Glutamic Acid; Hippocampus; Tritium | 1988 |
Spontaneous release of endogenous aspartate and glutamate from rat striatal slices is increased following destruction of local neurons by ibotenic acid.
Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Neurons; Oxazoles; Rats | 1988 |
Maturational changes in retinal excitatory amino acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding, Competitive; Chick Embryo; Embryonic and Fetal Development; Glutamates; Glutamic Acid; Ibotenic Acid; Kinetics; N-Methylaspartate; Receptors, Amino Acid; Receptors, Cell Surface; Retina | 1988 |
Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801.
Topics: Animals; Anticonvulsants; Aspartic Acid; Calcium; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; N-Methylaspartate; Rats; Retina; Retinal Ganglion Cells | 1988 |
Focal cerebral ischaemia in the cat: treatment with the glutamate antagonist MK-801 after induction of ischaemia.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain Ischemia; Cats; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate | 1988 |
Phorbol esters attenuate glutamate-stimulated inositol phospholipid hydrolysis in neuronal cultures.
Topics: Animals; Aspartic Acid; Carbachol; Cerebellum; Diglycerides; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; N-Methylaspartate; Neurons; Oxadiazoles; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Sphingosine; Tetradecanoylphorbol Acetate | 1988 |
An intracellular analysis of amino acid induced excitations of deep dorsal horn neurones in the rat spinal cord slice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; Intracellular Membranes; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Spinal Cord; Tetrodotoxin; Valine | 1988 |
The amino acid sequence of bovine thymus prothymosin alpha.
Topics: Alanine; Amino Acid Sequence; Animals; Aspartic Acid; Cattle; Glutamates; Glutamic Acid; Humans; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Rats; Serine; Species Specificity; Thymosin; Thymus Gland | 1988 |
Phosphorylation of phosvitin by casein kinase-2 provides the evidence that phosphoserines can replace carboxylic amino acids as specificity determinants.
Topics: Amino Acids; Aspartic Acid; Casein Kinases; Egg Proteins; Glutamates; Glutamic Acid; Phosphorylation; Phosphoserine; Phosphothreonine; Phosvitin; Protein Kinases; Serine; Substrate Specificity | 1988 |
Glutamate stimulates somatostatin release from diencephalic neurons in primary culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Diencephalon; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Phencyclidine; Potassium; Quisqualic Acid; Rats; Somatostatin; Tetrodotoxin; Valine; Veratridine | 1988 |
Regulation of glutamate and aspartate release from slices of the hippocampal CA1 area: effects of adenosine and baclofen.
Topics: Adenosine; Animals; Aspartic Acid; Baclofen; Calcium; Female; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Potassium; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synapses; Veratridine | 1988 |
Pharmacological induction of use-dependent receptive field modifications in the visual cortex.
Topics: Acetylcholine; Animals; Aspartic Acid; Cats; Glutamates; Glutamic Acid; N-Methylaspartate; Neuronal Plasticity; Neurons; Norepinephrine; Photic Stimulation; Reference Values; Vision, Ocular; Visual Cortex | 1988 |
L-aspartate and L-glutamate binding sites in developing normal and 'nervous' mutant mouse cerebellum.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Cerebellum; Female; Glutamates; Glutamic Acid; Kinetics; Male; Mice; Mice, Inbred C3H; Mice, Neurologic Mutants; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter | 1987 |
[Epileptic seizure model utilizing additive effects of excitatory amino acids].
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Drug Synergism; Electroencephalography; Epilepsy; Glutamates; Glutamic Acid; Injections; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains | 1988 |
Subcellular distribution of malate-aspartate cycle intermediates during normoxia and anoxia in the heart.
Topics: Adenine Nucleotides; Anaerobiosis; Animals; Aspartic Acid; Citrates; Citric Acid; Citric Acid Cycle; Cytosol; Glutamates; Glutamic Acid; Glutamine; Ketoglutaric Acids; Lactates; Lactic Acid; Malates; Male; Mitochondria, Heart; Myocardium; Oxygen; Phosphocreatine; Rats; Rats, Inbred Strains; Subcellular Fractions | 1988 |
Transient increased density of NMDA binding sites in the developing rat hippocampus.
Topics: Aging; Animals; Aspartic Acid; Autoradiography; Binding, Competitive; Glutamates; Glutamic Acid; Hippocampus; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Behavioral classification of excitatory amino acid receptors in mouse spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Behavior, Animal; Glutamates; Glutamic Acid; Glutamine; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Valine | 1988 |
Tetrahydroaminoacridine selectively attenuates NMDA receptor-mediated neurotoxicity.
Topics: Aminoacridines; Animals; Aspartic Acid; Cells, Cultured; Cholinesterase Inhibitors; Glutamates; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tacrine | 1988 |
Excitatory amino acid release from rat hippocampal slices as a consequence of free-radical formation.
Topics: Allopurinol; Amino Acids; Animals; Aspartic Acid; Catalase; Free Radicals; Glutamates; Glutamic Acid; Hippocampus; Hydroxides; Hydroxyl Radical; Male; Mannitol; Norepinephrine; Rats; Rats, Inbred Strains; Superoxide Dismutase; Superoxides; Xanthine; Xanthine Oxidase; Xanthines | 1988 |
In vivo metabolism of nitrogen precursors for urea synthesis in the postprandial rat.
Topics: Alanine; Ammonium Chloride; Animals; Aspartic Acid; Food; Glutamates; Glutamic Acid; Glutamine; Kidney; Liver; Male; Nitrogen; Nitrogen Isotopes; Rats; Urea | 1988 |
The effect of ketone bodies on alanine and glutamine metabolism in isolated skeletal muscle from the fasted chick.
Topics: Alanine; Amino Acids, Branched-Chain; Animals; Aspartic Acid; Chickens; Fasting; Glucose; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Intracellular Fluid; Ketone Bodies; Muscles; Pyruvates; Pyruvic Acid | 1988 |
Effect of cortical kindling on [3H]D-aspartate uptake and glutamate metabolism in rats.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; In Vitro Techniques; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains | 1987 |
[Effect of antagonists of excitatory amino acids on synaptic transmission in the electroreceptors (Lorenzini's ampullae) in skates].
Topics: 2-Aminoadipic Acid; Animals; Aspartic Acid; Electric Fish; Electric Organ; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; Pipecolic Acids; Skates, Fish; Synapses; Synaptic Transmission | 1988 |
Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Glutamates; Glutamic Acid; Glycine; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Relationship between prostaglandin synthesis and release of acidic amino acid neurotransmitters.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspartic Acid; Calcium; Cerebellum; Glutamates; Glutamic Acid; Models, Neurological; Nerve Endings; Neurotransmitter Agents; Prostaglandins; Rats; Synaptic Transmission | 1988 |
Effects of pharmacological manipulations on basal and newly synthesized levels of GABA, glutamate, aspartate and glutamine in mouse brain cortex.
Topics: 2-Amino-5-phosphonovalerate; 3-Mercaptopropionic Acid; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Male; Mice; N-Methylaspartate; Valproic Acid | 1988 |
Identification of aspartate-184 as an essential residue in the catalytic subunit of cAMP-dependent protein kinase.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Carbon Radioisotopes; Catalysis; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Chymotrypsin; Cyclic AMP; Dicyclohexylcarbodiimide; Glutamates; Glutamic Acid; Glycine; Peptide Fragments; Protein Kinase Inhibitors; Protein Kinases; Swine; Trypsin | 1988 |
The effect of an uptake inhibitor (dihydrokainate) on endogenous excitatory amino acids in the lamprey spinal cord as revealed by microdialysis.
Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Kainic Acid; Lampreys; Neurotransmitter Agents; Reference Values; Spinal Cord | 1988 |
Activation of protein kinase C induces a long-term depression of glutamate sensitivity of cerebellar Purkinje cells. An in vitro study.
Topics: Animals; Aspartic Acid; Cerebellum; Electric Conductivity; Enzyme Activation; Glutamates; Glutamic Acid; In Vitro Techniques; Nerve Fibers; Protein Kinase C; Purkinje Cells; Rats; Rats, Inbred Strains; Reference Values | 1988 |
X-ray studies on crystalline complexes involving amino acids and peptides. XV. Crystal structures of L-lysine D-glutamate and L-lysine D-aspartate monohydrate and the effect of chirality on molecular aggregation.
Topics: Aspartic Acid; Crystallization; Dipeptides; Glutamates; Glutamic Acid; Hydrogen Bonding; Lysine; Molecular Structure; Protein Conformation; X-Ray Diffraction | 1988 |
Rhythmic discharge properties of caudal cochlear nucleus neurons during postnatal development in cats.
Topics: Age Factors; Animals; Aspartic Acid; Auditory Pathways; Brain Stem; Cats; Cochlear Nerve; Evoked Potentials, Auditory; Glutamates; Glutamic Acid; Loudness Perception; Neurons; Pitch Discrimination | 1988 |
Effect of inhibitors of gamma-glutamyl transpeptidase on the uptake of glutamate and aspartate into cultured astroglial cells from the glycogen body and cerebral hemispheres of the embryonic chick.
Topics: Animals; Aspartic Acid; Astrocytes; Biological Transport; Borates; Brain; Cells, Cultured; Chick Embryo; Diazooxonorleucine; gamma-Glutamyltransferase; Glutamates; Glutamic Acid; Kainic Acid; Serine; Spinal Cord | 1988 |
Epinephrine and norepinephrine modulate neuronal responses to excitatory amino acids and agonists in frog spinal cord.
Topics: Amino Acids; Animals; Aspartic Acid; Epinephrine; Glutamates; Glutamic Acid; In Vitro Techniques; Isoproterenol; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Norepinephrine; Oxadiazoles; Quisqualic Acid; Rana pipiens; Reference Values; Spinal Cord; Yohimbine | 1987 |
Reversible shifts in the Ca2+-dependent release of aspartate and glutamate from hippocampal slices with changing glucose concentrations.
Topics: Animals; Aspartic Acid; Calcium; Glucose; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Rats; Reference Values | 1987 |
Properties of two classes of rat brain acidic amino acid receptors induced by distinct mRNA populations in Xenopus oocytes.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glycine; Kainic Acid; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; RNA, Messenger; Xenopus laevis | 1988 |
Glutamate and dynorphin release from a subcellular fraction enriched in hippocampal mossy fiber synaptosomes.
Topics: Animals; Aspartic Acid; Deoxyglucose; Dynorphins; Enkephalins; Glutamates; Glutamic Acid; Hippocampus; Male; Microscopy, Electron; Protein Precursors; Rats; Rats, Inbred Strains; Synaptosomes | 1988 |
Putative glutamatergic and/or aspartatergic cells in the main and accessory olfactory bulbs of the rat.
Topics: Animals; Aspartic Acid; Autoradiography; Cerebral Cortex; Glutamates; Glutamic Acid; Olfactory Bulb; Rats | 1988 |
The neuroexcitotoxic amino acids glutamate and aspartate are altered in the spinal cord and brain in amyotrophic lateral sclerosis.
Topics: Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Cerebellar Cortex; Cerebral Cortex; Glutamates; Glutamic Acid; Humans; Middle Aged; Neurotoxins; Reference Values; Spinal Cord | 1988 |
Amino acid neurotransmitter deficits in adult Down's syndrome brain tissue.
Topics: Adult; Aspartic Acid; Brain Chemistry; Down Syndrome; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Middle Aged; Organ Specificity; Reference Values | 1988 |
Structural and functional integrity of specificity and catalytic sites of trypsin.
Topics: Aspartic Acid; Binding Sites; Escherichia coli; Glutamates; Glutamic Acid; Kinetics; Models, Theoretical; Serine; Trypsin; Trypsinogen | 1988 |
Commentary on a review on the mechanism of ackee-induced vomiting sickness.
Topics: Acidosis; Aspartic Acid; Cyclopropanes; Glutamates; Glutamic Acid; Humans; Hypoglycins; Plant Poisoning; Vomiting | 1988 |
Prevention of insulin aggregation by dicarboxylic amino acids during prolonged infusion.
Topics: Animals; Artificial Organs; Aspartic Acid; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Drug Implants; Female; Glutamates; Glutamic Acid; Insulin; Islets of Langerhans; Macromolecular Substances; Male | 1981 |
L-Aspartate binding sites in rat cerebellum: a comparison of the binding of L-[3H]aspartate and L-[3H]glutamate to synaptic membranes.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cations; Cerebellum; Female; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Rats; Synaptic Membranes; Temperature; Tritium | 1981 |
A stereoselective anomaly in dicarboxylic amino acid transport.
Topics: Amino Acids, Sulfur; Animals; Aspartic Acid; Biological Transport; Cells, Cultured; Cysteic Acid; Cysteine; Fibroblasts; Glutamates; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Liver; Neurotransmitter Agents; Rats; Sodium; Stereoisomerism; Sulfinic Acids | 1981 |
Initiation of Bacillus subtilis sporulation by the stringent response to partial amino acid deprivation.
Topics: Amino Acids; Aspartic Acid; Bacillus subtilis; Biological Transport; Glutamates; Glutamic Acid; Kinetics; Methionine; Mutation; Species Specificity; Spores, Bacterial | 1981 |
Uptake of exogenous glutamate and aspartate by circumventricular organs but not other regions of brain.
Topics: Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Hypothalamus; Kinetics; Mice; Rats | 1981 |
Effect of glucose on aspartate and glutamate synthesis by human diploid fibroblasts.
Topics: Aspartic Acid; Cell Line; Fibroblasts; Glucose; Glutamates; Glutamic Acid; Humans; Pyruvates; Pyruvic Acid | 1981 |
Glutamate as a putative transmitter in the cerebellum: stimulation by GABA of glutamic acid release from specific pools.
Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Cyclic GMP; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kinetics; Male; Neurotransmitter Agents; Rats; Synaptosomes; Veratridine | 1981 |
Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Drug Antagonism; Electric Conductivity; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; N-Methylaspartate; Neurons; Organophosphorus Compounds; Rats; Valine | 1981 |
Effects of the neuroexcitatory amino acids aspartate and glutamate on LH secretion.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Female; Follicle Stimulating Hormone; Glutamates; Glutamic Acid; Injections, Intraventricular; Luteinizing Hormone; Rats; Rats, Inbred Strains | 1981 |
Studies on the release of exogenous and endogenous GABA and glutamate from rat brain synaptosomes.
Topics: Animals; Aspartic Acid; Brain; Calcimycin; Calcium; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Potassium; Rats; Synaptosomes; Veratridine | 1981 |
The presynaptic effects of valproic acid in the isolated frog spinal cord.
Topics: Afferent Pathways; Animals; Aspartic Acid; Electric Conductivity; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Potassium; Rana pipiens; Spinal Cord; Synapses; Valproic Acid | 1981 |
Perforant path lesion depletes glutamate content of fascia dentata synaptosomes.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hippocampus; Male; Rats; Rats, Inbred Strains; Synaptic Transmission; Synaptosomes | 1981 |
Amino acid sequence homologies between the high-mobility-group proteins, HMG-T from trout testis and HMG-1 and -2 from calf thymus: is the poly-aspartic-glutamic acid polypeptide within the main chain?
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cattle; Chromosomal Proteins, Non-Histone; Cyanogen Bromide; Glutamates; Glutamic Acid; High Mobility Group Proteins; Male; Peptides; Testis; Thymus Gland; Trout | 1981 |
Stimulation of rat cerebellar guanosine 3',5'-cyclic monophosphate (cyclic GMP) levels: effects of amino acid antagonists.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cerebellum; Cyclic GMP; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; N-Methylaspartate; Protoveratrines; Rats; Rats, Inbred Strains | 1981 |
Excitatory effect of L-aspartate and L-glutamate on Purkinje cells in rat cerebellum.
Topics: Action Potentials; Animals; Aspartic Acid; Cerebellum; Electric Conductivity; Glutamates; Glutamic Acid; Neurons; Purkinje Cells; Rats | 1981 |
Amino acids as central synaptic transmitters or modulators in mammalian thermoregulation.
Topics: Amino Acids; Animals; Aspartic Acid; Body Temperature Regulation; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Humans; Models, Neurological; Neurotransmitter Agents; Synapses; Taurine | 1981 |
D-aspartate potentiates the effects of L-glutamate on horizontal cells in goldfish retina.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug Synergism; Glutamates; Glutamic Acid; Goldfish; Light; Membrane Potentials; Retina; Stereoisomerism | 1981 |
Excitatory amino acid receptors.
Topics: Animals; Aspartic Acid; Binding Sites; Brain; Glutamates; Glutamic Acid; Humans; Kainic Acid; Kinetics; Neurons; Parkinson Disease; Protein Conformation; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord | 1981 |
Dicarboxylate transport in maize mesophyll chloroplasts.
Topics: Aspartic Acid; Biological Transport, Active; Chloroplasts; Dicarboxylic Acids; Glutamates; Glutamic Acid; Ketoglutaric Acids; Kinetics; Malates; Oxaloacetates; Thermodynamics; Zea mays | 1981 |
L-glutamate and L-aspartate bind to separate sites in rat brain synaptic membranes.
Topics: Animals; Aspartic Acid; Binding, Competitive; Brain; Calcium; Glutamates; Glutamic Acid; Kinetics; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate; Sodium; Synaptic Membranes | 1981 |
Uptake of aspartic and glutamic acid by photoreceptors in goldfish retina.
Topics: Animals; Aspartic Acid; Autoradiography; Glutamates; Glutamic Acid; Goldfish; Photoreceptor Cells; Retina; Stereoisomerism; Structure-Activity Relationship; Tritium | 1981 |
Comparative effects of aspartate and glutamate during myocardial ischemia.
Topics: Animals; Aspartic Acid; Blood Pressure; Cats; Coronary Disease; Glutamates; Glutamic Acid; In Vitro Techniques; Myocardial Contraction | 1981 |
Platelet glutamate and aspartate uptake in Huntington's disease.
Topics: Aspartic Acid; Biological Transport; Blood Platelets; Glutamates; Glutamic Acid; Humans; Huntington Disease; Kinetics; Reference Values | 1981 |
Specific and non-specific effects of neuro-excitatory amino acids on learning and other behaviours in the chicken.
Topics: Aggression; Aging; Animals; Aspartic Acid; Behavior, Animal; Chickens; Copulation; Glutamates; Glutamic Acid; Habituation, Psychophysiologic; Humans; Kainic Acid; Learning; N-Methylaspartate; Pattern Recognition, Visual; Pyrrolidines; Visual Perception | 1982 |
The action of six antagonists of the excitatory amino acids on neurones of the rat spinal cord.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Rats; Spinal Cord; Structure-Activity Relationship | 1982 |
Stimulated release of 3H-glycine from retina.
Topics: Animals; Aporphines; Aspartic Acid; Cysteic Acid; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Isoxazoles; Kainic Acid; Muscimol; Rabbits; Retina | 1982 |
Physiology and in situ identification of putative aminergic neurotransmitters in the nervous system of Gyrocotyle fimbriata, a parasitic flatworm.
Topics: Animals; Aspartic Acid; Cestoda; Electrophysiology; Glutamates; Glutamic Acid; Histocytochemistry; Neurotransmitter Agents; Spectrometry, Fluorescence; Synaptic Transmission | 1982 |
Activity of the enantiomers of 2-amino-5-phosphono-valeric acid as stereospecific antagonists of excitatory aminoacids.
Topics: Adipates; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Rats; Stereoisomerism; Synaptic Transmission | 1981 |
The effect of kainic acid on excitatory synaptic activity in the rat hippocampal slice preparation.
Topics: Acetylcholine; Animals; Aspartic Acid; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Pyrrolidines; Rats; Synapses | 1981 |
Transport of L-aspartate and L-glutamate in plasma-membrane vesicles from rat liver.
Topics: Animals; Aspartic Acid; Biological Transport, Active; Cell Membrane; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Membrane Potentials; Rats; Rats, Inbred Strains; Sodium; Substrate Specificity; Time Factors | 1982 |
The topographical distribution of alanine, aspartate, gamma-aminobutyric acid, glutamate, glutamine, and glycine in the pigeon optic tectum and the effect of retinal ablation.
Topics: Alanine; Animals; Aspartic Acid; Columbidae; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Kinetics; Male; Optic Nerve; Retina; Superior Colliculi; Taurine | 1982 |
Cysteine sulfinic acid in the central nervous system: antagonistic effect of taurine on cysteine sulfinic acid-stimulated formation of cyclic AMP in guinea pig hippocampal slices.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Cysteine; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Male; Neurotransmitter Agents; Taurine | 1982 |
Regional amino acid distribution in relation to function in insulin hypoglycaemia.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Catalepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Humans; Hypoglycemia; Insulin; Male; Rats; Rats, Inbred Strains; Tissue Distribution | 1982 |
Effects of N-acetyl aspartate, aspartate, and glutamate on cAMP and cGMP levels in developing rat cerebral cortex.
Topics: Adenylyl Cyclases; Animals; Aspartic Acid; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Glutamates; Glutamic Acid; Guanylate Cyclase; Male; Rats; Rats, Inbred Strains | 1982 |
Aspartate: possible neurotransmitter in cerebellar climbing fibers.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Neural Pathways; Neurotransmitter Agents; Rats | 1982 |
[Participation of alpha-amino group of amino acids in ammonia production in heart muscle].
Topics: Amino Acids; Ammonia; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Kinetics; Leucine; Myocardium; Nitrogen Isotopes; Rats | 1982 |
L-glutamate increases the spontaneous release of [3H]GABA from cultured cerebellar neurons.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellar Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Rats; Sodium; Stereoisomerism; Stimulation, Chemical | 1982 |
Huntington's disease. Glutamate and aspartate metabolism in blood platelets.
Topics: Adult; Asparagine; Aspartic Acid; Blood Platelets; Female; Glutamates; Glutamic Acid; Glutamine; Humans; Huntington Disease; Kinetics; Male; Middle Aged | 1982 |
Elevation of cerebral levels of nonessential amino acids in vivo by administration of large doses.
Topics: Amino Acids; Animals; Aspartic Acid; Blood-Brain Barrier; Brain; Food, Formulated; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Male; Mice; Mice, Inbred BALB C; Stomach | 1981 |
Hereditary high concentration of glutathione in canine erythrocytes associated with high accumulation of glutamate, glutamine, and aspartate.
Topics: Amino Acids; Animals; Aspartic Acid; Dogs; Erythrocytes; Glutamates; Glutamic Acid; Glutamine; Glutathione; Pedigree | 1982 |
The distribution of glutamate, GABA and aspartate in the nucleus tractus solitarius of the cat.
Topics: Animals; Aspartic Acid; Cats; Cranial Nerves; Denervation; Functional Laterality; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Medulla Oblongata; Tissue Distribution | 1982 |
Ammonia assimilation and synthesis of alanine, aspartate, and glutamate in Methanosarcina barkeri and Methanobacterium thermoautotrophicum.
Topics: Alanine; Alanine Dehydrogenase; Amino Acid Oxidoreductases; Ammonia; Ammonium Chloride; Aspartic Acid; Euryarchaeota; Glutamate Dehydrogenase; Glutamate Synthase; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid | 1982 |
Aspartate may be an excitatory transmitter mediating visual excitation of "sustained" but not "transient" cells in the cat retina: iontophoretic studies in vivo.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cats; Dipeptides; Glutamates; Glutamic Acid; Neurons; Neurotransmitter Agents; Retina; Synaptic Transmission; Valine | 1982 |
2-amino-4-phosphonobutyric acid and N-methyl-D-aspartate differentiate between "3H]glutamate and [3H] aspartate binding sites in bovine retina.
Topics: Aminobutyrates; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cattle; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; N-Methylaspartate; Neurons; Retina; Synaptic Membranes | 1982 |
Relationships between amino acid catabolism and protein anabolism in the ruminant.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cattle; Diabetes Mellitus, Experimental; Gluconeogenesis; Glutamates; Glutamic Acid; Leucine; Liver; Muscles; Proteins; Sheep | 1982 |
Formation of proline metabolites in chick embryo bone: interference with the measurement of free hydroxyproline by ion-exchange chromatography.
Topics: 1-Pyrroline-5-Carboxylate Dehydrogenase; Animals; Aspartic Acid; Bone and Bones; Chick Embryo; Chromatography, Ion Exchange; Collagen; False Positive Reactions; Glutamates; Glutamic Acid; Hydroxyproline; Oxidoreductases Acting on CH-NH Group Donors; Proline; Proline Oxidase | 1982 |
Human prostatic acid phosphatase: a histidine phosphatase.
Topics: Acid Phosphatase; Arginine; Aspartic Acid; Binding Sites; Chemical Phenomena; Chemistry; Glutamates; Glutamic Acid; Histidine; Humans; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Male; Phosphotransferases; Prostate | 1982 |
Baclofen: effects on evoked field potentials and amino acid neurotransmitter release in the rat olfactory cortex slice.
Topics: Animals; Aspartic Acid; Baclofen; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Neural Inhibition; Olfactory Bulb; Potassium; Rats; Synapses; Synaptic Transmission; Taurine | 1982 |
Putative acidic amino acid transmitters in the cerebellum. I. Depolarization-induced release.
Topics: Amino Acids; Animals; Aspartic Acid; Autoradiography; Cerebellum; Culture Techniques; Glutamates; Glutamic Acid; Male; Muridae; Neuroglia; Neurons; Synaptic Transmission; Synaptosomes | 1982 |
Electrophysiological analysis of rat renal sugar and amino acid transport. V. Acidic amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport; Carbohydrate Metabolism; Cell Membrane; Electrophysiology; Glutamates; Glutamic Acid; Kidney Tubules, Proximal; Rats | 1982 |
Effect of amino acids on microbial production of citric acid by Aspergillus niger.
Topics: Amino Acids; Aspartic Acid; Aspergillus niger; Citrates; Citric Acid; Cysteine; Glutamates; Glutamic Acid; Lysine; Serine | 1982 |
Variations in aortal elastin composition after atherogenic diet feeding in rats. Possible involvement of two different elastin types.
Topics: Amino Acids; Animals; Aorta; Arginine; Aspartic Acid; Diet, Atherogenic; Elastin; Glutamates; Glutamic Acid; Male; Rats; Rats, Inbred Strains; Tyrosine | 1982 |
Electroneutral Na+/dicarboxylic amino acid cotransport in rat intestinal brush border membrane vesicles.
Topics: Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Biological Transport; Biological Transport, Active; Cell Membrane; Glucose; Glutamates; Glutamic Acid; Intestine, Small; Kinetics; Microvilli; Rats; Sodium | 1982 |
Glutamate and aspartate do not modify the ataxic gait of acrylamide treated animals.
Topics: Acrylamides; Animals; Aspartic Acid; Gait; Glutamates; Glutamic Acid; Locomotion; Male; Motor Activity; Rats | 1982 |
Lateral olfactory tract transmitter: glutamate, aspartate, or neither?
Topics: Aminobutyrates; Animals; Aspartic Acid; Central Nervous System; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Neurotransmitter Agents; Olfactory Pathways; Rats | 1981 |
Depolarization of retinal horizontal cells by excitatory amino acid neurotransmitter agonists.
Topics: Amino Acids; Animals; Aspartic Acid; Fishes; Glutamates; Glutamic Acid; Kainic Acid; Membrane Potentials; Neurotransmitter Agents; Retina; Structure-Activity Relationship | 1982 |
Effect of kainic acid, glutamate, and aspartate on CO2 production by goldfish tectal slices.
Topics: Animals; Aspartic Acid; Carbon Dioxide; Glutamates; Glutamic Acid; Goldfish; Kainic Acid; Ouabain; Pyrrolidines; Sodium-Potassium-Exchanging ATPase; Superior Colliculi; Time Factors | 1982 |
Glutamine and alpha-ketoglutarate uptake and metabolism by nerve terminal enriched material from mouse cerebellum.
Topics: Animals; Aspartic Acid; Biological Transport; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Ketoglutaric Acids; Mice; Mice, Inbred ICR; Nerve Endings; Neurons; Sodium | 1982 |
Age-related changes in the glutamate metabolism of cerebral cortical slices from rats.
Topics: Aging; Animals; Aspartic Acid; Carbon Dioxide; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains | 1982 |
[Effect of glutamic and aspartic acids on heart metabolism and function in hypoperfusion].
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Perfusion; Phosphocreatine; Rats; Rats, Inbred Strains | 1982 |
Conductance changes induced by DL-homocysteic acid and N-methyl-DL-aspartic acid in hippocampal neurons.
Topics: Animals; Aspartic Acid; Cell Membrane; Electric Conductivity; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Homocysteine; In Vitro Techniques; Iontophoresis; Manganese; N-Methylaspartate; Tetrodotoxin | 1982 |
Cerebellar macroneurons in microexplant cell culture. Postsynaptic amino acid pharmacology.
Topics: Amino Acids; Animals; Aspartic Acid; Cell Differentiation; Cerebellum; Culture Techniques; Fetus; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Horseradish Peroxidase; Membrane Potentials; Neurons; Purkinje Cells; Rats; Synapses; Synaptic Transmission | 1982 |
L-Glutamic acid as an excitatory transmitter at the crayfish neuromuscular junction.
Topics: Animals; Aspartic Acid; Astacoidea; Electric Stimulation; Glutamates; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Neuromuscular Junction; Neurotransmitter Agents; Spider Venoms | 1982 |
Selective potentiation of retinal horizontal cell responses to L-glutamate by D-aspartate.
Topics: Animals; Aspartic Acid; Drug Synergism; Glutamates; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Neurotransmitter Agents; Photoreceptor Cells; Retina; Stereoisomerism | 1982 |
The excitatory actions of a series of piperidine dicarboxylates on central neurons of the rat, snail, leech and horseshoe crab and on crab neuromuscular junction.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Helix, Snails; Horseshoe Crabs; In Vitro Techniques; Leeches; Neuromuscular Junction; Neurons; Piperidines; Rats; Species Specificity | 1982 |
Effect of urethane on synaptic and amino acid-induced excitation in isolated spinal cord preparations.
Topics: Animals; Aspartic Acid; Evoked Potentials; Ganglia, Spinal; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Ranidae; Rats; Spinal Cord; Synapses; Urethane | 1982 |
[Total parenteral nutrition of premature infants: metabolic effects of an exogenous supply of L-aspartic acid and L-glutamic acid].
Topics: Amino Acids; Aspartic Acid; Body Height; Body Weight; Gestational Age; Glutamates; Glutamic Acid; Humans; Infant, Newborn; Infant, Premature; Male; Parenteral Nutrition; Stereoisomerism; Water-Electrolyte Balance | 1982 |
Characterization of the excitatory amino acid receptor-mediated release of [3H]acetylcholine from rat striatal slices.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Afferent Pathways; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Interneurons; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine | 1982 |
Baclofen: inhibition of the release of L-[3H]glutamate and L-[3H]aspartate from rat whole brain synaptosomes.
Topics: Animals; Aspartic Acid; Baclofen; Brain; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Potassium; Rats; Rats, Inbred Strains; Synaptosomes; Time Factors | 1982 |
Hemoglobin I (alpha 16(A14) Lys replaced by Glu) and hemoglobin J Iran (beta 77(EF1) His replaced by Asp) discovered in Japanese.
Topics: Aspartic Acid; Female; Globins; Glutamates; Glutamic Acid; Hemoglobin J; Hemoglobins; Hemoglobins, Abnormal; Histidine; Humans; Japan; Lysine; Male; Middle Aged | 1982 |
Effects of anoxia on the stimulated release of amino acid neurotransmitters in the cerebellum in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebellum; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Hypoxia; In Vitro Techniques; Kinetics; Male; Neurotransmitter Agents; Potassium; Rats; Rats, Inbred Strains; Tetrodotoxin | 1983 |
Excitatory amino acid receptors and guanosine 3',5'-cyclic monophosphate in incubated slices of immature and adult rat cerebellum.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Rats; Receptors, Amino Acid; Receptors, Cell Surface | 1982 |
Effects of D-alpha-aminoadipate on excitation of afferent fibers in the lateral line of Xenopus laevis.
Topics: 2-Aminoadipic Acid; Afferent Pathways; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Female; Glutamates; Glutamic Acid; Hair Cells, Auditory; Kainic Acid; Male; Mechanoreceptors; Motor Activity; N-Methylaspartate; Synaptic Transmission; Xenopus laevis | 1982 |
Esterification of the carboxyl groups in fibrinogen by the application of a highly specific methylating agent.
Topics: Animals; Aspartic Acid; Carboxylic Acids; Cattle; Chemical Phenomena; Chemistry, Physical; Esterification; Fibrinogen; Glutamates; Glutamic Acid; Macromolecular Substances; Methylation; Onium Compounds | 1982 |
May enzyme activity in urine play a role in kidney stone formation?
Topics: Alanine; Alanine Transaminase; Aspartate Aminotransferases; Aspartic Acid; Calcium Oxalate; Chemical Precipitation; Glutamates; Glutamic Acid; Humans; Kidney Calculi | 1982 |
Schistosoma mansoni: incorporation and metabolism of protein amino acids in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Egg Proteins; Female; Glutamates; Glutamic Acid; Glycine; Ovum; Proteins; Schistosoma mansoni | 1982 |
The suppression of stimulus-evoked release of amino acid neurotransmitters from synaptosomes by verapamil.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Calcium; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Synaptosomes; Tetrodotoxin; Threonine; Verapamil; Veratridine | 1983 |
Pharmacologic sensitivity of amino acid responses and synaptic activation of in vitro prepyriform neurons.
Topics: Animals; Aspartic Acid; Cats; Glutamates; Glutamic Acid; In Vitro Techniques; Iontophoresis; Neurotransmitter Agents; Olfactory Bulb; Olfactory Pathways; Rats; Species Specificity; Synaptic Transmission | 1982 |
Release of [3H]L-glutamine acid (L-Glu) and [3H]D-aspartic acid (D-Asp) in the area of nucleus tractus solitarius in vivo produced by stimulation of the vagus nerve.
Topics: Animals; Aspartic Acid; Blood Pressure; Electric Stimulation; Glutamates; Glutamic Acid; Male; Medulla Oblongata; Neurotransmitter Agents; Potassium; Rats; Rats, Inbred Strains; Reflex; Synaptic Transmission; Vagus Nerve | 1983 |
Uptake of D-[3H]aspartic acid by hippocampal slices: the influence of low and high frequency activation of nerve endings.
Topics: Afferent Pathways; Animals; Aspartic Acid; Culture Techniques; Glutamates; Glutamic Acid; Hippocampus; Membrane Potentials; Nerve Endings; Rats; Synaptic Transmission | 1983 |
Effect of D- and L-alpha-aminoadipate on the efflux of L-aspartate, L-glutamate and gamma-aminobutyrate from superfused rat brain slices.
Topics: 2-Aminoadipic Acid; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Brain; Culture Techniques; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Neural Inhibition; Neurons; Potassium; Rats; Rats, Inbred Strains; Stereoisomerism; Synaptic Transmission | 1983 |
Chronic infusion of endogenous excitatory amino acids into rat striatum and hippocampus.
Topics: Animals; Aspartic Acid; Corpus Striatum; Cysteine; Glutamates; Glutamic Acid; Hippocampus; Male; Neurotransmitter Agents; Rats | 1983 |
Purification and characterization of the heat-stable factors essential for the conversion of lignoceric acid to cerebronic acid and glutamic acid: identification of N-acetyl-L-aspartic acid.
Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Fatty Acids; Glutamates; Glutamic Acid; Hot Temperature; Magnetic Resonance Spectroscopy; Rats | 1983 |
Glutamine and glucose as precursors of transmitter amino acids: ex vivo studies.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport, Active; Brain; Cerebral Cortex; Female; Glucose; Glutamates; Glutamic Acid; Glutamine; Hippocampus; Rats; Rats, Inbred Strains; Time Factors; Tissue Distribution | 1983 |
Biochemical development of the human brain. III. Benzodiazepine receptors, free gamma-aminobutyrate (GABA) and other amino acids.
Topics: Adult; Aged; Aging; Amino Acids; Aspartic Acid; Brain; Cerebellum; Female; Flunitrazepam; Frontal Lobe; gamma-Aminobutyric Acid; Gestational Age; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Glutamine; Humans; Infant; Infant, Newborn; Kinetics; Middle Aged; Pregnancy; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Excitatory amino acids and potassium release in the frog spinal cord.
Topics: Afferent Pathways; Amino Acids; Animals; Aspartic Acid; Baclofen; Electric Stimulation; Ganglia, Spinal; Glutamates; Glutamic Acid; Membrane Potentials; Potassium; Ranidae; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Synapses; Synaptic Transmission | 1982 |
Use of post-mortem human synaptosomes for studies of metabolism and transmitter amino acid release.
Topics: Adult; Aged; Amino Acids; Aspartic Acid; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Male; Microscopy, Electron; Middle Aged; Potassium; Synapses; Synaptic Transmission; Synaptosomes | 1982 |
Regulation of the n-acetylglutamate content of rat hepatocytes by the glutamate concentration.
Topics: Ammonia; Animals; Aspartic Acid; Citrulline; Diet; Glutamates; Glutamic Acid; Liver; Ornithine; Rats; Urea | 1982 |
Histamine as a ligand in blood plasma. Part 6. Aspartate and glutamate as possible partner ligands for zinc and histamine to favour histamine catabolism.
Topics: Aspartic Acid; Cysteine; Diffusion; Glutamates; Glutamic Acid; Histamine; Humans; Ligands; Zinc | 1982 |
Role of pyruvate carboxylation in the energy-linked regulation of pool sizes of tricarboxylic acid-cycle intermediates in the myocardium.
Topics: Alanine; Animals; Aspartic Acid; Bicarbonates; Citrates; Citric Acid; Citric Acid Cycle; Female; Glutamates; Glutamic Acid; Heart Arrest; In Vitro Techniques; Ketoglutaric Acids; Kinetics; Malates; Mitochondria, Heart; Myocardium; Potassium Chloride; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1982 |
Role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cats; Dipeptides; Female; Glutamates; Glutamic Acid; Male; Pipecolic Acids; Receptors, Neurotransmitter; Spinal Cord; Synaptic Transmission; Valine | 1983 |
Characterization of separated cell types from the developing rat cerebellum: transport of glutamate and aspartate by preparations enriched in Purkinje cells, granule neurones, and astrocytes.
Topics: Amino Acids; Animals; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Kinetics; Neurons; Purkinje Cells; Rats; Rats, Inbred Strains | 1983 |
Release of endogenous amino acids from superior colliculus of the rabbit: in vitro studies after retinal ablation.
Topics: Amino Acids; Animals; Aspartic Acid; beta-Alanine; Functional Laterality; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Kinetics; Rabbits; Retina; Superior Colliculi; Taurine | 1983 |
Enhancement of neurite outgrowth and aspartate-glutamate uptake systems in retinal explants cultured with chick gizzard extract.
Topics: Animals; Aspartic Acid; Axons; Biological Transport; Chick Embryo; Chickens; Gizzard, Avian; Glutamates; Glutamic Acid; Kinetics; Neurons; Organ Culture Techniques; Retina; Tissue Extracts | 1983 |
Identification of specific carboxylate groups on cytochrome c oxidase that are involved in binding cytochrome c.
Topics: Animals; Aspartic Acid; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Copper; Cytochrome c Group; Electron Transport; Electron Transport Complex IV; Ethyldimethylaminopropyl Carbodiimide; Glutamates; Glutamic Acid; In Vitro Techniques; Protein Conformation | 1983 |
Desensitization to glutamate does not affect synaptic transmission in rat hippocampal slices.
Topics: Animals; Aspartic Acid; Culture Techniques; Dendrites; Dose-Response Relationship, Drug; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Rats; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1983 |
Post-excitatory depression of neuronal firing by acidic amino acids and acetylcholine in the cat spinal cord.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Cats; Evoked Potentials; Ganglia, Spinal; Glutamates; Glutamic Acid; Interneurons; Spinal Cord; Synaptic Transmission | 1983 |
Carrier-mediated release of GABA from retinal horizontal cells.
Topics: Animals; Aspartic Acid; Autoradiography; Carrier Proteins; Evoked Potentials, Visual; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Goldfish; Neurons; Photoreceptor Cells; Retina; Sodium; Synaptic Transmission; Visual Pathways; Visual Perception | 1983 |
Investigations into the mechanism of excitant amino acid cytotoxicity using a well-characterized glutamatergic system.
Topics: Animals; Aspartic Acid; Concanavalin A; Cysteine; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Grasshoppers; Kainic Acid; Nerve Degeneration; Neuromuscular Junction; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Receptors, Cell Surface; Receptors, Glutamate; Synaptic Transmission | 1983 |
Effect of glutamic and aspartic acids on adenine nucleotides, nitrogenous compounds and contractile function during underperfusion of isolated rat heart.
Topics: Adenine Nucleotides; Amino Acids; Ammonia; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Heart; Male; Myocardial Contraction; Myocardium; Perfusion; Phosphocreatine; Rats; Rats, Inbred Strains; Triacetoneamine-N-Oxyl | 1983 |
Neurochemical and pharmacological correlates of inferior olive destruction in the rat: attenuation of the events mediated by an endogenous glutamate-like substance.
Topics: Afferent Pathways; Animals; Aspartic Acid; Brain Mapping; Cyclic GMP; Female; Glutamates; Glutamic Acid; Nerve Fibers; Olivary Nucleus; Purkinje Cells; Pyridines; Rats; Rats, Inbred Strains; Synaptic Transmission; Synaptosomes | 1983 |
Selective antagonist activity of 5-aminohex-2-enedioic acid on amino acid excitation of cat spinal neurones.
Topics: 2-Aminoadipic Acid; Amino Acids; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Cats; Glutamates; Glutamic Acid; Interneurons; N-Methylaspartate; Neurons; Spinal Cord; Structure-Activity Relationship | 1980 |
The effect of decortication on the excitatory amino acid sensitivity of striatal neurones.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Glutamates; Glutamic Acid; Kainic Acid; Neurons; Rats | 1980 |
Kinetics and localization of tubular resorption of "acidic" amino acids. A microperfusion and free flow micropuncture study in rat kidney.
Topics: Animals; Aspartic Acid; Biological Transport, Active; Glutamates; Glutamic Acid; Kidney Tubules; Kinetics; Male; Perfusion; Rats; Rats, Inbred Strains | 1983 |
Molecular specificity of the tubular resorption of "acidic" amino acids. A continuous microperfusion study in rat kidney in vivo.
Topics: 1-Carboxyglutamic Acid; Amino Acids; Animals; Aspartic Acid; Cysteic Acid; Glutamates; Glutamic Acid; Kidney Tubules; Kinetics; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Stereoisomerism; Structure-Activity Relationship | 1983 |
Effects of excess amounts of synthetic amino acid preparations on hypothalamus of mice and kittens.
Topics: Amino Acids; Animals; Animals, Suckling; Aspartic Acid; Cats; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hypothalamus; Mice | 1983 |
Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Amino Acids; Aspartic Acid; Dementia; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Potassium; Temporal Lobe | 1983 |
Presynaptic kainate and N-methyl-D-aspartate receptors regulate excitatory amino acid release in the olfactory cortex.
Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Neurotransmitter Agents; Olfactory Bulb; Potassium; Rats; Receptors, Cell Surface; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1983 |
Development of neurotransmitter parameters in lateral geniculate body, superior colliculus and visual cortex of the albino rat.
Topics: Alanine; Animals; Aspartic Acid; Cell Differentiation; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Geniculate Bodies; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Kinetics; Neurotransmitter Agents; Rats; Superior Colliculi; Visual Cortex; Visual Pathways | 1983 |
Distribution of glycine, GABA, aspartate and glutamate in the rat spinal cord.
Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Rats; Rats, Inbred Strains; Spinal Cord; Tissue Distribution | 1983 |
Dicarboxylic amino acids shunt in mitochondria of amphibian oocytes.
Topics: Amino Acids, Dicarboxylic; Animals; Aspartate Aminotransferases; Aspartic Acid; Female; Glutamates; Glutamic Acid; Isocitrates; Malate Dehydrogenase; Malates; Mitochondria; Oocytes; Ovum; Xenopus laevis | 1983 |
Pathways of L-glutamic acid transport in cultured human fibroblasts.
Topics: Aminoisobutyric Acids; Aspartic Acid; Biological Transport; Cell Count; Cells, Cultured; Fibroblasts; Glutamates; Glutamic Acid; Humans; Kinetics; Serine; Sodium | 1983 |
Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Kinetics; Neurotransmitter Agents; Pyridoxine; Rabbits; Seizures; Taurine; Tissue Distribution | 1983 |
Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro.
Topics: Absorption; Amino Acids; Animals; Aspartic Acid; Calcium; Cerebral Cortex; Glutamates; Glutamic Acid; Homocysteine; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Rats | 1983 |
Quantitative autoradiography of sodium-dependent [3H]D-aspartate binding sites in rat brain.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Rats; Sodium | 1983 |
The function of vitamin A.
Topics: Animals; Arginine; Aspartic Acid; Bacteriorhodopsins; Biological Transport; Cell Differentiation; Cell Nucleus; Glutamates; Glutamic Acid; Halorhodopsins; Humans; Lysine; Ocular Physiological Phenomena; Rhodopsin; Tyrosine; Vitamin A | 1983 |
Levels and synthesis of glutamate and aspartate in the olfactory cortex following bulbectomy.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Female; Functional Laterality; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Kinetics; Male; Olfactory Bulb | 1983 |
Evidence for the identification of synaptic transmitters released by photoreceptors of the toad retina.
Topics: Animals; Aspartic Acid; Bufo marinus; Cadaverine; Cells, Cultured; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Histidine; Neurotransmitter Agents; Photoreceptor Cells; Putrescine; Retina; Synapses; Time Factors | 1983 |
The relationship between glutamate deamination and gluconeogenesis in kidney.
Topics: Aminobutyrates; Animals; Aspartic Acid; Deamination; Gluconeogenesis; Glutamates; Glutamic Acid; In Vitro Techniques; Kidney; Kidney Tubules; Male; Perfusion; Phosphoenolpyruvate Carboxykinase (GTP); Picolinic Acids; Rats; Rats, Inbred Strains; Transaminases | 1983 |
The role of potassium and chloride ions on the Na+/acidic amino acid cotransport system in rat intestinal brush-border membrane vesicles.
Topics: Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Biological Transport; Cell Membrane; Chlorides; Glutamates; Glutamic Acid; Intestinal Mucosa; Kinetics; Microvilli; Potassium; Rats; Sodium | 1983 |
[Motor activity and the content of neuroactive amino acids in brain tissues].
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cats; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Hypothalamus; Male; Physical Exertion; Rats | 1983 |
Regional cortical glutamergic and aspartergic projections to the amygdala and thalamus of the rat.
Topics: Amygdala; Animals; Aspartic Acid; Cerebral Cortex; Dominance, Cerebral; Glutamates; Glutamic Acid; Male; Neural Pathways; Rats; Rats, Inbred Strains; Synaptic Transmission; Thalamic Nuclei | 1983 |
The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain and plasma amino acids in the rat.
Topics: Alanine; Amino Acids; Ammonia; Animals; Aspartic Acid; Brain; Brain Stem; Cerebral Cortex; Energy Metabolism; Glutamates; Glutamic Acid; Glutamine; Hepatectomy; Male; Rats | 1983 |
In vivo release from cerebral cortex of [14C]glutamate synthesized from [U-14C]glutamine.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Male; Rats; Rats, Inbred Strains; Scorpion Venoms | 1983 |
Comparison of the effects of a convulsant barbiturate on the release of endogenous and radiolabeled amino acids from slices of mouse hippocampus.
Topics: Amino Acids; Animals; Aspartic Acid; Barbiturates; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Male; Mice; Potassium; Time Factors | 1983 |
Effect of aspartame loading on plasma and erythrocyte free amino acid concentrations in one-year-old infants.
Topics: Adult; Age Factors; Amino Acids; Aspartame; Aspartic Acid; Dipeptides; Dose-Response Relationship, Drug; Erythrocytes; Glutamates; Glutamic Acid; Humans; Infant; Phenylalanine; Tyrosine | 1983 |
L-glutamic acid: a neurotransmitter candidate for cone photoreceptors in human and rat retinas.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Autoradiography; Biological Transport; Glutamates; Glutamic Acid; Histocytochemistry; Humans; Male; Neurotransmitter Agents; Photoreceptor Cells; Rats; Rats, Inbred Strains; Species Specificity; Tritium | 1983 |
Amino acid neurotransmitter release from cerebrocortical synaptosomes of sheep with severe ryegrass staggers in New Zealand.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; Indole Alkaloids; Mycotoxins; Nervous System Diseases; Neurotransmitter Agents; Sheep; Sheep Diseases; Synaptosomes | 1983 |
Suppressing action of 2-amino-4-phosphonobutyric acid on mossy fiber-induced excitation in the guinea pig hippocampus.
Topics: Aminobutyrates; Animals; Aspartic Acid; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Nerve Fibers; Neurons; Receptors, Cell Surface; Receptors, Glutamate; Synapses; Synaptic Transmission | 1983 |
Presence of N-methyl-D-aspartate-like and kainate-like activities in bovine brain.
Topics: Animals; Aspartic Acid; Brain Chemistry; Carbon Radioisotopes; Cattle; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Pyrrolidines | 1983 |
Excitatory amino acids: modes of action on hippocampal pyramidal cells.
Topics: Action Potentials; Animals; Aspartic Acid; Calcium; Electric Conductivity; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Ion Channels; Membrane Potentials; N-Methylaspartate; Potassium; Receptors, Cell Surface; Receptors, Glutamate; Synapses | 1983 |
A method for manual determination of glutamate, glutamine, GABA and aspartate from brain regions.
Topics: Animals; Aspartic Acid; Brain Chemistry; Chromatography, Ion Exchange; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Indicators and Reagents; Male; Rats; Rats, Inbred Strains; Sex Factors | 1983 |
Neuroactive amino acids influence gonadotrophin output by a suprapituitary mechanism in either rodents or primates.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Luteinizing Hormone; Macaca fascicularis; Macaca nemestrina; Male; N-Methylaspartate; Papio; Rats; Rats, Inbred Strains | 1983 |
Uptake and release of D-aspartate in the guinea pig cochlear nucleus.
Topics: Animals; Aspartic Acid; Calcium; Cochlea; Denervation; Ear Ossicles; Electric Stimulation; Glutamates; Glutamic Acid; Guinea Pigs; Medulla Oblongata; Tissue Distribution | 1983 |
Effects of excitatory amino acids on locomotor activity after bilateral microinjection into the rat nucleus accumbens: possible dependence on dopaminergic mechanisms.
Topics: Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Male; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Seizures; Septal Nuclei; Synaptic Transmission | 1983 |
[Compartmentalization of metabolism of spatially-delimiting amino acid pools of yeast cells].
Topics: Alanine; Amino Acids; Aspartic Acid; Candida; Cell Compartmentation; Cytoplasm; Glutamates; Glutamic Acid; Kinetics; Mitochondria; Organoids; Structure-Activity Relationship; Vacuoles; Valine | 1983 |
Effects of excitatory amino acids on dopamine synthesis in the rat retina.
Topics: Amino Acids; Animals; Aspartic Acid; Dopamine; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Retina | 1983 |
Selective inhibition of synaptosomal proline uptake by leucine and methionine enkephalins.
Topics: Animals; Aspartic Acid; Biological Transport; Cerebral Cortex; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kinetics; Neurotransmitter Agents; Proline; Rats; Rats, Inbred Strains; Synaptosomes; Taurine | 1983 |
Amino acids in the dorsal lateral geniculate nucleus of the cat--collection in vivo.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cats; Evoked Potentials, Visual; gamma-Aminobutyric Acid; Geniculate Bodies; Glutamates; Glutamic Acid; Glycine; Synaptic Transmission; Taurine; Visual Pathways | 1983 |
Functional organization of the visual cortex.
Topics: Afferent Pathways; Animals; Aspartic Acid; Cats; Deoxyglucose; Dominance, Cerebral; Efferent Pathways; Glutamates; Glutamic Acid; Haplorhini; Neurotransmitter Agents; Pyramidal Tracts; Species Specificity; Synapses; Visual Cortex | 1983 |
Effects of glutamate and aspartate on sympathetic preganglionic neurons in the upper thoracic intermediolateral nucleus of the cat.
Topics: Animals; Aspartic Acid; Autonomic Fibers, Preganglionic; Cats; Evoked Potentials; Ganglia, Sympathetic; Glutamates; Glutamic Acid; Homocysteine; Neurons; Spinal Cord; Synapses; Synaptic Transmission | 1983 |
Voltage clamp analysis of the effect of excitatory amino acids and derivatives on Purkinje cell dendrites in rat cerebellar slices maintained in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Culture Techniques; Dendrites; Glutamates; Glutamic Acid; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Synaptic Transmission | 1983 |
Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Aspartic Acid; Evoked Potentials; Folic Acid; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neural Pathways; Oxadiazoles; Pyrrolidines; Quisqualic Acid; Rats | 1983 |
Electrical stimulation of the stratum radiatum increases the release and neosynthesis of aspartate, glutamate, and gamma-aminobutyric acid in rat hippocampal slices.
Topics: Animals; Aspartic Acid; Electric Stimulation; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Glucose; Glutamates; Glutamic Acid; Hippocampus; Male; Rats; Rats, Inbred Strains | 1983 |
Release of endogenous and accumulated exogenous amino acids from slices of normal and climbing fibre-deprived rat cerebellar slices.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Cerebellum; Corpus Striatum; Glutamates; Glutamic Acid; Magnesium; Olivary Nucleus; Pyridines; Rats | 1983 |
N-methyl aspartate activates voltage-dependent calcium conductance in rat hippocampal pyramidal cells.
Topics: Action Potentials; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Ion Channels; N-Methylaspartate; Neural Conduction; Neurons; Potassium; Rats | 1983 |
Effects of excitatory amino acids, and of their agonists and antagonists on the release of neurotransmitters from the chick retina.
Topics: Amino Acids; Animals; Aspartic Acid; Chickens; Cysteic Acid; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Endings; Neurotransmitter Agents; Receptors, Neurotransmitter; Retina; Synapses; Synaptic Transmission | 1983 |
Purification and characterization of beta-glucuronidase inhibitor from Mycobacterium tuberculosis.
Topics: Amino Acids; Aspartic Acid; Glucuronidase; Glutamates; Glutamic Acid; Glycoproteins; Hydrogen-Ion Concentration; Isoelectric Point; Molecular Weight; Mycobacterium tuberculosis | 1983 |
Adrenergic inhibition of branched-chain 2-oxo acid dehydrogenase in rat diaphragm muscle in vitro.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Animals; Aspartic Acid; Bucladesine; Epinephrine; Glutamates; Glutamic Acid; In Vitro Techniques; Ketone Oxidoreductases; Male; Multienzyme Complexes; Muscles; Oxidation-Reduction; Phenylephrine; Rats; Rats, Inbred Strains; Valine | 1983 |
Asymmetric distribution of acetylcholine receptors and M channels on prepyriform neurons.
Topics: Acetylcholine; Action Potentials; Animals; Aspartic Acid; Brain Mapping; Calcium; Cerebral Cortex; Glutamates; Glutamic Acid; Homocysteine; Pilocarpine; Rats; Receptors, Cholinergic; Receptors, Muscarinic | 1983 |
Effect of meal components on peripheral and portal plasma glutamate levels in young pigs administered large doses of monosodium-L-glutamate.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cellobiose; Diet; Dietary Carbohydrates; Glutamates; Glutamic Acid; Insulin; Male; Portal Vein; Sodium Glutamate; Swine; Venae Cavae | 1984 |
Metabolism of amino acids in Ascaridia galli: transamination.
Topics: Alanine; Alanine Transaminase; Amino Acids; Animals; Ascaridia; Aspartate Aminotransferases; Aspartic Acid; Cytosol; Female; Glutamates; Glutamic Acid; Ketoglutaric Acids; Male; Mitochondria | 1983 |
Accumulation of putative amino acid neurotransmitters, monoamines and D-Ala2-Met-enkephalinamide in primary astroglial cultures from various brain areas, visualized by autoradiography.
Topics: Amino Acids; Animals; Aspartic Acid; Astrocytes; Autoradiography; Brain; Culture Techniques; Dopamine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Valine | 1983 |
Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell cultures.
Topics: Animals; Aspartic Acid; Astrocytes; Autoradiography; Cell Differentiation; Cell Membrane Permeability; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Neurons; Rats; Rats, Inbred Strains | 1984 |
Release of aspartate and glutamate caused by chloride reduction in synaptosomal incubation media.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Chlorides; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Rats; Synaptosomes | 1984 |
Differential sensitivity of selected brain areas to excitatory amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Rats; Sodium; Stimulation, Chemical | 1983 |
Effects of hypoglycemia on the transmitter pool and the metabolic pool of glutamate in rat brain.
Topics: Animals; Aspartic Acid; Blood Glucose; Corpus Striatum; Glutamates; Glutamic Acid; Glutamine; Insulin; Rats; Rats, Inbred Strains; Synaptic Transmission | 1983 |
Effects of amino acids on cat red nucleus neurons in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cats; Culture Techniques; Dose-Response Relationship, Drug; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Magnesium; Neurons; Red Nucleus; Synaptic Transmission | 1984 |
Oral glutamate loading in disorders with spinocerebellar and extrapyramidal involvement: effect on plasma glutamate, aspartate and taurine.
Topics: Aspartic Acid; Atrophy; Basal Ganglia Diseases; Cerebellar Diseases; Cerebellum; Friedreich Ataxia; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Humans; Nerve Degeneration; Olivary Nucleus; Parkinson Disease; Pons; Shy-Drager Syndrome; Sodium Glutamate; Spinal Cord Diseases; Taurine | 1983 |
Decreased uptake and release of D-aspartate in the guinea pig spinal cord after dorsal root section.
Topics: Animals; Aspartic Acid; Calcium; gamma-Aminobutyric Acid; Ganglia, Spinal; Glutamates; Glutamic Acid; Guinea Pigs; Spinal Cord | 1984 |
Excitotoxic amino acids as neuroendocrine research tools.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Axons; Blood-Brain Barrier; Brain; Glutamates; Glutamic Acid; Neurotoxins; Organ Specificity; Structure-Activity Relationship | 1983 |
Increase of Na+ gradient-dependent L-glutamate and L-aspartate transport in high K+ dog erythrocytes associated with high activity of (Na+, K+)-ATPase.
Topics: Animals; Aspartic Acid; Biological Transport, Active; Dogs; Erythrocytes; Glutamates; Glutamic Acid; Membrane Potentials; Ouabain; Potassium; Sodium; Sodium-Potassium-Exchanging ATPase; Valinomycin | 1984 |
Intralaminar neurochemical distributions in human midtemporal cortex: comparison between Alzheimer's disease and the normal.
Topics: Acetylcholinesterase; Alzheimer Disease; Aspartic Acid; Butyrylcholinesterase; Cerebral Cortex; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Reference Values | 1984 |
Uptake of D-aspartate and L-glutamate in excitatory axon terminals in hippocampus: autoradiographic and biochemical comparison with gamma-aminobutyrate and other amino acids in normal rats and in rats with lesions.
Topics: Absorption; Amino Acids; Animals; Aspartic Acid; Autoradiography; Axons; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Male; Neuroglia; Neurons; Rats; Rats, Inbred Strains | 1984 |
On the sensitivity of H1 horizontal cells of the carp retina to glutamate, aspartate and their agonists.
Topics: Animals; Aspartic Acid; Carps; Glutamates; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Retina | 1984 |
Amino acid transmitter candidates in various regions of the primary olfactory cortex following bulbectomy.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Neurotransmitter Agents; Olfactory Bulb; Rats; Taurine; Tissue Distribution | 1984 |
2-Ketoglutarate and the regulation of aconitase and histidase formation in Bacillus subtilis.
Topics: Aconitate Hydratase; Ammonia-Lyases; Aspartic Acid; Bacillus subtilis; Enzyme Repression; Glucose; Glutamates; Glutamic Acid; Histidine Ammonia-Lyase; Ketoglutaric Acids; Mutation | 1984 |
Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure.
Topics: Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Coenzymes; Glutamates; Glutamic Acid; Kinetics; Ligands; Models, Molecular; Protein Conformation; Substrate Specificity; X-Ray Diffraction | 1984 |
Metabolism of the glutamate group of amino acids in rat brain as a function of age.
Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Energy Metabolism; Enzymes; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Male; Rats; Rats, Inbred Strains | 1984 |
Changes in medium radioactivity and composition accompany high-affinity uptake of glutamate and aspartate by mouse brain slices.
Topics: Animals; Aspartic Acid; Biological Transport; Brain; Carbon Radioisotopes; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred Strains | 1984 |
Neurochemical, pharmacological, and developmental studies on cerebellar receptors for dicarboxylic amino acids.
Topics: Animals; Aspartic Acid; Cerebellum; Female; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate; Subcellular Fractions; Tritium | 1984 |
[Effects of acute ammonia poisoning on cerebral amino acids metabolism in rats].
Topics: Acute Disease; Amino Acids; Ammonia; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Male; Rats | 1984 |
Localization of L-glutamate and L-aspartate synaptic receptors in chick retinal neurons.
Topics: Animals; Aspartic Acid; Chickens; Glutamates; Glutamic Acid; Kainic Acid; Male; Neurons; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter; Retina | 1984 |
Responses of solitary retinal horizontal cells to L-glutamate and kainic acid are antagonized by D-aspartate.
Topics: Animals; Aspartic Acid; Cyprinidae; Excitatory Amino Acid Antagonists; Folic Acid; Glutamates; Glutamic Acid; Goldfish; Interneurons; Kainic Acid; Pyrrolidines; Retina; Stereoisomerism | 1984 |
Veratridine-induced release in vivo and in vitro of amino acids in the rabbit olfactory bulb.
Topics: Amino Acids; Animals; Aspartic Acid; Culture Techniques; Glutamates; Glutamic Acid; Olfactory Bulb; Rabbits; Synaptic Transmission; Veratridine; Veratrine | 1984 |
l-Glutamate reduces the affinity of [3H]N-propylnorapomorphine binding sites in striatal membranes.
Topics: Animals; Antiparkinson Agents; Apomorphine; Aspartic Acid; Binding Sites; Cell Membrane; Corpus Striatum; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Spiperone | 1984 |
[Effect of glutamic and aspartic amino acids on the electrical activity of the ampullae of Lorenzini in skates].
Topics: Animals; Aspartic Acid; Electric Organ; Electrophysiology; Fishes; Glutamates; Glutamic Acid; Sensory Receptor Cells | 1984 |
Effect of lesions of the olfactory bulb on the levels of amino acids and related enzymes in the olfactory cortex of the guinea pig.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glutaminase; Guinea Pigs; Malate Dehydrogenase; Olfactory Bulb | 1984 |
Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid.
Topics: Allylglycine; Amino Acids; Animals; Aspartic Acid; Bicuculline; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Kainic Acid; Male; Neurotransmitter Agents; Pyrrolidines; Rats; Rats, Inbred Strains; Seizures; Taurine | 1984 |
Plasma glutamate and aspartate concentrations in young infants on Neopham.
Topics: Amino Acids; Aspartic Acid; Drug Evaluation; Electrolytes; Erythrocytes; Female; Glucose; Glutamates; Glutamic Acid; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Male; Nitrogen; Parenteral Nutrition Solutions; Parenteral Nutrition, Total; Solutions | 1983 |
Sensitivity of hippocampal neurons to glutamic acid and its analogues.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Homocysteine; In Vitro Techniques; Membrane Potentials; Molecular Conformation; Receptors, Cell Surface; Receptors, Glutamate; Stereoisomerism | 1982 |
Cells in the anteroventral cochlear nucleus are insensitive to L-glutamate and L-aspartate; excitatory synaptic responses are not blocked by D-alpha-aminoadipate.
Topics: 2-Aminoadipic Acid; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Cochlear Nerve; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Medulla Oblongata; Membrane Potentials; Mice; Mice, Inbred Strains; Nerve Fibers; Neurons; Synapses; Synaptic Transmission; Vestibulocochlear Nerve | 1984 |
Evidence for a role of neurotransmitters in the mechanism of topical convulsant models.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Aspartic Acid; Brain; Choline O-Acetyltransferase; Disease Models, Animal; Dopamine; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Neurotransmitter Agents; Norepinephrine; Rats; Seizures; Taurine | 1984 |
Neuromuscular modulation in Limulus by both octopamine and proctolin.
Topics: Animals; Aspartic Acid; Biogenic Amines; Calcium; Drug Interactions; Evoked Potentials; Glutamates; Glutamic Acid; Horseshoe Crabs; In Vitro Techniques; Muscle Contraction; Muscles; Neuromuscular Junction; Neuropeptides; Neurotransmitter Agents; Octopamine; Oligopeptides | 1984 |
Neurotransmitter amino acids in the CNS. II. Some changes in amino acid levels in rat brain synaptosomes during and after in vitro anoxia and simulated ischemia.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Culture Techniques; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Hypoxia, Brain; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Synaptosomes; Tetrodotoxin; Veratridine | 1984 |
Neurotransmitter amino acids in the CNS. I. Regional changes in amino acid levels in rat brain during ischemia and reperfusion.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Synaptic Transmission; Taurine | 1984 |
Gamma-D-glutamylglycine and cis-2,3-piperidine dicarboxylate as antagonists of excitatory amino acids in the hippocampus.
Topics: Amino Acids; Animals; Aspartic Acid; Depression, Chemical; Dipeptides; Excitatory Amino Acid Antagonists; Glutamic Acid; Guinea Pigs; Homocysteine; In Vitro Techniques; Neurotransmitter Agents; Pipecolic Acids; Synapses; Synaptic Transmission | 1984 |
Effects of glutamic acid, kainic acid and aspartic acid on GABA release from rat retina degenerated by kainic acid.
Topics: Animals; Aspartic Acid; Depression, Chemical; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Male; Pyrrolidines; Rats; Retina; Retinal Degeneration; Stimulation, Chemical | 1984 |
Stimulation of deoxy[3H]glucose uptake into slices from cerebral cortex elicited by excitatory amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Cysteic Acid; Deoxy Sugars; Deoxyglucose; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Potassium; Rats; Veratridine | 1984 |
Effect of excitatory amino acids on Purkinje cell dendrites in cerebellar slices from normal and staggerer mice.
Topics: Amino Acids; Animals; Aspartic Acid; Crosses, Genetic; Dendrites; Glutamates; Glutamic Acid; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Neurologic Mutants; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid | 1984 |
[GABA, glutamate, aspartate, glycine, and taurine contents in spinocerebellar degeneration and parkinsonism].
Topics: Adult; Aged; Amino Acids; Aspartic Acid; Brain Chemistry; Cerebellar Ataxia; Chromatography, High Pressure Liquid; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Neurotransmitter Agents; Parkinson Disease; Taurine | 1984 |
Effects of serotonin on cerebellar Purkinje cells are dependent on the baseline firing rate.
Topics: Action Potentials; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Glycine; Male; Methysergide; Purkinje Cells; Rats; Serotonin; Time Factors | 1984 |
Cerebral cortex and amino acid neurotransmitters: higher levels of aspartic acid but not GABA in the frontal cortex of the rat.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Male; Neurotransmitter Agents; Occipital Lobe; Parietal Lobe; Rats; Rats, Inbred Strains; Temporal Lobe; Tissue Distribution | 1984 |
Amino acid transport by synaptosomes isolated from post mortem human brain.
Topics: Alanine; Amino Acids; Aspartic Acid; Biological Transport; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; In Vitro Techniques; Oxygen Consumption; Postmortem Changes; Synaptosomes; Veratrine | 1984 |
Mixed-agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Culture Techniques; Electric Conductivity; Glutamates; Glutamic Acid; Homocysteine; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Spinal Cord; Valine | 1984 |
The uptake and release of glutamate at the crayfish neuromuscular junction.
Topics: Animals; Aspartic Acid; Astacoidea; Electric Stimulation; Glutamates; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Muscles; Neuromuscular Junction; Potassium; Time Factors | 1984 |
Inhibition of synaptosomal uptake of amino acid transmitters by diamines.
Topics: Amino Acids; Animals; Aspartic Acid; Biological Transport; Depression, Chemical; Diamines; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Neurotransmitter Agents; Rats; Rats, Inbred F344; Rats, Inbred Strains; Synaptosomes | 1984 |
Evidence for a neurotransmitter role of aspartate and/or glutamate in the projection from the torus longitudinalis to the optic tectum of the goldfish.
Topics: Animals; Aspartic Acid; Cyprinidae; Glutamates; Glutamic Acid; Goldfish; Mesencephalon; Superior Colliculi; Synaptic Transmission; Visual Pathways | 1984 |
The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Atmospheric Pressure; Brain; Fasting; Glutamates; Glutamic Acid; Male; Myoclonus; Rats; Rats, Inbred Strains; Seizures; Synaptic Transmission; Syndrome; Tremor | 1984 |
Recent aspartame studies.
Topics: Adult; Animals; Aspartame; Aspartic Acid; Brain Chemistry; Dipeptides; Drug Interactions; Glutamates; Glutamic Acid; Humans; Infant; Methanol; Phenylalanine; Sodium Glutamate | 1984 |
Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis.
Topics: Amino Acids; Animals; Aspartic Acid; Blood-Brain Barrier; Dialysis; Extracellular Space; Glutamates; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Male; Rats; Rats, Inbred Strains | 1984 |
Decrease in N-acetyl-L-aspartic acid in brain of myodystrophic mice.
Topics: Animals; Aspartic Acid; Brain; Female; Glutamates; Glutamic Acid; Male; Mice; Mice, Mutant Strains; Muscular Dystrophy, Animal; Sex Factors | 1984 |
Symmetrical distribution of amino acid neurotransmitters in the right and left cerebral cortex of the rat.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Glycine; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Serine; Threonine; Tissue Distribution | 1984 |
The effect of D-alpha-aminoadipate on excitatory amino acid responses recorded intracellularly from motoneurones of the frog spinal cord.
Topics: 2-Aminoadipic Acid; Amino Acids; Amino Acids, Dicarboxylic; Animals; Anterior Horn Cells; Aspartic Acid; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana temporaria; Spinal Nerve Roots | 1984 |
Selective association of N-methyl aspartate and quisqualate types of L-glutamate receptor with brain postsynaptic densities.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Chlorides; Glutamates; Glutamic Acid; Kinetics; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Membranes | 1984 |
Determination of GOT activity on nucleation and crystal growth of calcium oxalate.
Topics: Aspartate Aminotransferases; Aspartic Acid; Calcium Oxalate; Crystallization; Glutamates; Glutamic Acid; Humans; Urinary Calculi | 1984 |
Four biochemically different types of dominantly inherited olivopontocerebellar atrophy.
Topics: Adult; Aged; Amino Acids; Aspartic Acid; Brain Chemistry; Cerebellar Ataxia; gamma-Aminobutyric Acid; Genes, Dominant; Glutamates; Glutamic Acid; Humans; Middle Aged; Neurotransmitter Agents; Olivary Nucleus; Pons; Syndrome; Taurine | 1984 |
Amino acid oxidation and alanine production in rat hemidiaphragm in vitro. Effects of dichloroacetate.
Topics: Acetates; Alanine; Amino Acids; Animals; Aspartic Acid; Diaphragm; Dichloroacetic Acid; Glucose; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Muscles; Oxidation-Reduction; Rats; Rats, Inbred Strains; Starvation | 1984 |
Arginine-vasopressin enhances the responses of lateral septal neurons in the rat to excitatory amino acids and fimbria-fornix stimuli.
Topics: Amino Acids; Animals; Arginine Vasopressin; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Muscimol; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Synapses | 1984 |
Regional synthesis of 14C-amino acids in cerebral cortex of the unanesthetized rat: simultaneous analysis by "push-pull" perfusion.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Male; Rats | 1984 |
Adenosine decreases aspartate and glutamate release from rat hippocampal slices.
Topics: Adenosine; Animals; Aspartic Acid; Corpus Striatum; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Mass Spectrometry; Phenylisopropyladenosine; Rats; Receptors, Cell Surface; Receptors, Purinergic; Theophylline; Xanthines | 1984 |
Evidence for glutamate as a neurotransmitter in the cat vestibular nerve: radioautographic and biochemical studies.
Topics: Animals; Aspartic Acid; Autoradiography; Cats; Glutamates; Glutamic Acid; Microscopy, Electron; Nerve Endings; Synaptic Transmission; Vestibular Nerve; Vestibular Nuclei | 1984 |
Amino acid neurotransmitters in the CNS: effect of thiopental.
Topics: Amino Acids; Anaerobiosis; Animals; Aspartic Acid; Biological Transport; Brain; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kinetics; Male; Neurotransmitter Agents; Potassium; Rats; Rats, Inbred Strains; Synaptosomes; Thiopental | 1984 |
Transganglionic transport of D-aspartate from cochlear nucleus to cochlea--a quantitative autoradiographic study.
Topics: Animals; Aspartic Acid; Autoradiography; Axons; Biological Transport; Cats; Cochlea; Dendrites; Glutamates; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory; Neurotransmitter Agents; Organ of Corti; Spiral Ganglion; Stereoisomerism; Time Factors; Tritium | 1984 |
Histochemical localization of aspartate aminotransferase activity in the hippocampal formation and in peripheral ganglia of the rat with special reference to the glutamate transmitter metabolism.
Topics: Age Factors; Animals; Aspartate Aminotransferases; Aspartic Acid; Ganglia, Spinal; Ganglia, Sympathetic; Glutamates; Glutamic Acid; Hippocampus; Male; Rats; Rats, Inbred Strains; Synaptic Transmission | 1984 |
Glutamate dehydrogenase and a proposed glutamate-aspartate pathway for citrate synthesis in rat ventral prostate.
Topics: Acetyl Coenzyme A; Animals; Aspartic Acid; Citrates; Citric Acid; Deamination; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Ketoglutaric Acids; Kidney; Male; Mitochondria; Prostate; Rats; Rats, Inbred Strains | 1984 |
Amino acid changes in regions of the CNS in relation to function in experimental portal-systemic encephalopathy.
Topics: Acetates; Amino Acids; Animals; Aspartic Acid; Central Nervous System; Glutamates; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Male; Portasystemic Shunt, Surgical; Rats; Rats, Inbred Strains | 1984 |
Modulation by bovine serum albumin of stimulated formation of cyclic AMP in guinea pig hippocampus.
Topics: Adenylyl Cyclases; Animals; Aspartic Acid; Cyclic AMP; Cysteine; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Neurotransmitter Agents; Serum Albumin, Bovine | 1984 |
Profile of amino acid synthesis in rat hippocampus during push-pull perfusion of ethanol or morphine.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Ethanol; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Hippocampus; Male; Morphine; Rats; Rats, Inbred Strains | 1984 |
Thiazolidine-2-carboxylate derivatives formed from glyoxylate and L-cysteine or L-cysteinylglycine as possible physiological substrates for D-aspartate oxidase.
Topics: Amino Acid Oxidoreductases; Animals; Aspartic Acid; Cattle; Cysteine; D-Aspartate Oxidase; Dipeptides; Glutamates; Glutamic Acid; Glyoxylates; Hydrogen-Ion Concentration; Proline; Substrate Specificity; Thiazolidines | 1984 |
Excitatory amino acid receptor interactions of a novel alpha-phosphinic acid analogue of alpha-methylaspartic acid.
Topics: Acetylcholine; Alanine; Animals; Anticonvulsants; Aspartic Acid; Cerebellum; Corpus Striatum; Electroshock; Glutamates; Glutamic Acid; In Vitro Techniques; Organophosphorus Compounds; Pentylenetetrazole; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Synaptosomes | 1984 |
[Effect of glutamic acid on the anaerobic formation of ATP in the heart muscle].
Topics: Adenosine Triphosphate; Anaerobiosis; Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Lactates; Myocardium; Pyruvates; Pyruvic Acid; Rats | 1984 |
Nuclear distribution of glutamate, gamma-aminobutyrate and aspartate within the normal human thalamus.
Topics: Aged; Aspartic Acid; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Synaptic Transmission; Thalamic Nuclei | 1984 |
Aspartate, glutamate and gamma-aminobutyric acid depolarize cultured astrocytes.
Topics: Animals; Aspartic Acid; Astrocytes; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Membrane Potentials; Rats; Taurine | 1984 |
Rheogenic property of Na+/acidic amino acid co-transport by guinea pig intestine.
Topics: Amino Acids; Animals; Aspartic Acid; Binding Sites; Biological Transport, Active; Glutamates; Glutamic Acid; Guinea Pigs; Ileum; Intestinal Absorption; Intestinal Mucosa; Kinetics; Microvilli; Sodium | 1984 |
[Conformation study, using an empirical atom-atom potential, of biologically active amino acids as neurotransmitters].
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Chemical Phenomena; Chemistry; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Molecular Conformation; Neurotransmitter Agents; Structure-Activity Relationship; Taurine | 1984 |
In vivo high-affinity uptake and axonal transport of D-[2,3-3H]aspartate in excitatory neurons.
Topics: Animals; Aspartic Acid; Autoradiography; Axonal Transport; Brain; Caudate Nucleus; Cerebral Cortex; Cerebral Ventricles; Cricetinae; Glutamates; Glutamic Acid; Hippocampus; Mesocricetus; Mice; Neurons; Putamen; Rats; Rats, Inbred Strains; Septum Pellucidum; Synaptic Transmission | 1981 |
Inner plexiform circuits in the carp retina: effects of cholinergic agonists, GABA, and substance P on the ganglion cells.
Topics: Acetylcholine; Animals; Aspartic Acid; Carps; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Neurons; Neurotransmitter Agents; Parasympathomimetics; Photic Stimulation; Retina; Substance P | 1982 |
Effect of thiamin deficiency on brain neurotransmitter systems.
Topics: Acetylcholine; Animals; Aspartic Acid; Brain; Diet; Glutamates; Glutamic Acid; Guanosine Monophosphate; Hydroxyindoleacetic Acid; Male; Neurotransmitter Agents; Pyrithiamine; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes; Thiamine Deficiency; Tissue Distribution | 1982 |
Effects of a low power laser beam guided by optic fiber on rat brain striatal monoamines and amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Caudate Nucleus; Corpus Striatum; Dopamine; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hydroxyindoleacetic Acid; Lasers; Norepinephrine; Rats; Serotonin | 1982 |
Time course of changes in glutamate and aspartate content in single layers of the guinea pig's superior colliculus after enucleation or cortical ablation.
Topics: Animals; Aspartic Acid; Axonal Transport; Glutamates; Glutamic Acid; Guinea Pigs; Male; Retina; Sensory Deprivation; Superior Colliculi; Visual Cortex; Visual Pathways | 1983 |
Neurotransmitter candidates of somatosensory primary afferent fibres.
Topics: Afferent Pathways; Animals; Aspartic Acid; Cholecystokinin; gamma-Aminobutyric Acid; Ganglia, Spinal; Glutamates; Glutamic Acid; Mechanoreceptors; Medulla Oblongata; Nerve Fibers; Neurotransmitter Agents; Nociceptors; Sensory Receptor Cells; Skin; Substance P; Synaptic Transmission; Vasoactive Intestinal Peptide | 1983 |
Decreased cysteine and proline synthesis in parenterally fed, premature infants.
Topics: Alanine; Amino Acids; Aspartic Acid; Birth Weight; Blood Glucose; Carbon Isotopes; Cysteine; Electrolytes; Energy Intake; Female; Food, Formulated; Gas Chromatography-Mass Spectrometry; Gestational Age; Glucose; Glutamic Acid; Glycine; Humans; Infant Food; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infant, Premature; Lipids; Male; Parenteral Nutrition; Parenteral Nutrition Solutions; Proline; Serine; Solutions | 1995 |
beta-Amyloid peptide fragment 25-35 potentiates the calcium-dependent release of excitatory amino acids from depolarized hippocampal slices.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Calcium; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Rats; Rats, Wistar | 1995 |
Studies of hypoxemic/reoxygenation injury: without aortic clamping. VIII. Counteraction of oxidant damage by exogenous glutamate and aspartate.
Topics: Alkadienes; Animals; Aspartic Acid; Cardiopulmonary Bypass; Glutamic Acid; Hemodynamics; Hypoxia; Lipid Peroxidation; Myocardial Contraction; Myocardial Reperfusion Injury; Swine; Ventricular Function, Left | 1995 |
Homonuclear J-refocused spectral editing technique for quantification of glutamine and glutamate by 1H NMR spectroscopy.
Topics: Algorithms; Aspartic Acid; Creatine; Feasibility Studies; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hydrogen; Image Enhancement; Magnetic Resonance Spectroscopy; Signal Processing, Computer-Assisted | 1995 |
Endogenous excitatory amino acid release from brain slices and astrocyte cultures evoked by trimethyltin and other neurotoxic agents.
Topics: Aging; Animals; Aspartic Acid; Astrocytes; Brain; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; In Vitro Techniques; Male; Neurotoxins; Ouabain; Potassium Chloride; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Sodium Glutamate; Taurine; Trimethyltin Compounds; Veratrine | 1995 |
Arachidonic acid and lysophosphatidylcholine modulate excitatory transmitter amino acid release from the rat cerebral cortex.
Topics: Animals; Arachidonic Acid; Aspartic Acid; Blood Gas Analysis; Cerebral Cortex; Glutamic Acid; Hydrogen-Ion Concentration; Lysophosphatidylcholines; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 1995 |
Effect of local cholecystokinin-8 administration on extracellular levels of amino acids and glycolytic products monitored by in vivo microdialysis in the fronto-parietal cortex of the rat.
Topics: Amino Acids; Animals; Aspartic Acid; Benzodiazepinones; Catecholamines; Frontal Lobe; Glutamic Acid; Microdialysis; Parietal Lobe; Phenylurea Compounds; Rats; Rats, Inbred Strains; Sincalide | 1995 |
Nitric oxide inhibition of the depolarization-evoked glutamate release from synaptosomes of rat cerebellum.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nitric Oxide; Nitroprusside; Potassium Chloride; Rats; Rats, Wistar; Synaptosomes | 1995 |
Massive persistent release of excitatory amino acids following human occlusive stroke.
Topics: Aspartic Acid; Carotid Artery, Internal; Carotid Stenosis; Cerebrovascular Disorders; Excitatory Amino Acids; Glutamic Acid; Humans; Male; Middle Aged | 1995 |
The transport of acidic amino acids and their analogues across monolayers of human intestinal absorptive (Caco-2) cells in vitro.
Topics: Amino Acids, Dicarboxylic; Anions; Aspartic Acid; Azides; Biological Transport; Caco-2 Cells; Cations; Cell Polarity; Colon; Dose-Response Relationship, Drug; Epithelium; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Ouabain; Sodium; Sodium Azide; Sodium-Potassium-Exchanging ATPase | 1995 |
Distribution of aspartate and glutamate in the nucleus of the solitary tract of the lamb.
Topics: Animals; Aspartic Acid; Cats; Glutamic Acid; Immunohistochemistry; Microtomy; Rats; Sheep; Solitary Nucleus; Species Specificity | 1995 |
Mass and positional isotopomer analysis of glucose metabolism in periportal and pericentral hepatocytes.
Topics: Alanine; Animals; Aspartic Acid; Blood Glucose; Carbon Isotopes; Digitonin; Glucose; Glutamic Acid; Isotope Labeling; Kinetics; Liver; Liver Glycogen; Male; Mathematics; Models, Theoretical; Perfusion; Rats; Rats, Sprague-Dawley | 1995 |
Prostaglandin E2 stimulates glutamate release from synaptosomes of rat spinal cord.
Topics: Amino Acids; Animals; Aspartic Acid; Dinoprostone; Dose-Response Relationship, Drug; Glutamic Acid; Male; Rats; Rats, Wistar; Spinal Cord; Synaptosomes; Time Factors | 1995 |
Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Brain; Brain Injuries; Cerebral Cortex; Glutamates; Glutamic Acid; Glutamine; Male; Microdialysis; Microinjections; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Serine | 1993 |
Inhibition of aminopeptidases by phosphonic acid and phosphinic acid analogues of aspartic and glutamic acids.
Topics: Aminopeptidases; Animals; Aspartic Acid; Cytosol; Glutamates; Glutamic Acid; Kidney; Kinetics; Microsomes; Organophosphonates; Phosphinic Acids; Swine | 1993 |
Effect of ageing on tissue levels of amino acids involved in the nitric oxide pathway in rat brain.
Topics: Aging; Amino Acid Oxidoreductases; Amino Acids; Animals; Arginine; Aspartic Acid; Brain Chemistry; Citrulline; Glutamates; Glutamic Acid; Male; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Rats; Rats, Wistar | 1993 |
In vivo effects of local and systemic phencyclidine on the extracellular levels of catecholamines and transmitter amino acids in the dorsolateral striatum of anaesthetized rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Catecholamines; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Extracellular Matrix; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Neurotransmitter Agents; Phencyclidine; Rats; Rats, Sprague-Dawley | 1994 |
Structure-function relationships in diphtheria toxin channels: III. Residues which affect the cis pH dependence of channel conductance.
Topics: Aspartic Acid; Diphtheria Toxin; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Ion Channels; Lipid Bilayers; Membrane Potentials; Membranes, Artificial; Mutation; Structure-Activity Relationship | 1994 |
Mutagenesis of the conserved aspartic acid 443, glutamic acid 478, asparagine 494, and aspartic acid 498 residues in the ribonuclease H domain of p66/p51 human immunodeficiency virus type I reverse transcriptase. Expression and biochemical analysis.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Conserved Sequence; DNA Mutational Analysis; Enzyme Stability; Escherichia coli; Glutamates; Glutamic Acid; HIV Reverse Transcriptase; HIV-1; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Protein Denaturation; Ribonuclease H; RNA-Directed DNA Polymerase; Structure-Activity Relationship | 1994 |
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine Maleate; Glioma; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Ion Channels; Kainic Acid; Kinetics; Magnesium Chloride; N-Methylaspartate; Neurotoxins; Pyrrolidinones; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Signal Transduction; Tumor Cells, Cultured | 1994 |
Anatomical and electrophysiological evidence for an excitatory amino acid pathway from the thalamic mediodorsal nucleus to the prefrontal cortex in the rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Aspartic Acid; Axonal Transport; Electric Stimulation; Glutamic Acid; Male; Neural Conduction; Neural Pathways; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, AMPA; Thalamic Nuclei | 1994 |
Amino acid immunocytochemistry of primary afferent terminals in the rat dorsal horn.
Topics: Afferent Pathways; Amino Acids; Animals; Aspartic Acid; Cholera Toxin; gamma-Aminobutyric Acid; Glutamic Acid; Horseradish Peroxidase; Immunohistochemistry; Male; Nerve Endings; Rats; Rats, Sprague-Dawley; Spinal Cord; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1994 |
Experimental study of the mechanism of seizure induction: changes in the concentrations of excitatory amino acids in the epileptic focus of the cat amygdaloid kindling model.
Topics: Amygdala; Animals; Aspartic Acid; Cats; Excitatory Amino Acids; Glutamic Acid; Seizures | 1994 |
L-NAME modulates glutamate accumulation induced by K(+)-depolarization but not by forebrain ischaemia in the rat striatum.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Aspartic Acid; Brain Ischemia; Glutamic Acid; Male; Microdialysis; Neostriatum; Neuromuscular Depolarizing Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Potassium; Rats; Rats, Wistar | 1994 |
Systemic phencyclidine administration is associated with increased dopamine, GABA, and 5-HIAA levels in the dorsolateral striatum of conscious rats: an in vivo microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Anesthesia; Animals; Aspartic Acid; Consciousness; Corpus Striatum; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Halothane; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Microdialysis; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin | 1994 |
Projections from the cerebral cortex to the accessory oculomotor nuclei of the rat: a neuroanatomical and immunohistochemical study.
Topics: Animals; Aspartic Acid; Axonal Transport; Cerebral Cortex; Glutamic Acid; Horseradish Peroxidase; Immunohistochemistry; Male; Neurons; Oculomotor Nerve; Rats; Rats, Wistar; Stereotaxic Techniques; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1994 |
Ion fluxes associated with excitatory amino acid transport.
Topics: Animals; Aspartic Acid; Biological Transport; Brain; Carrier Proteins; Chlorides; Electric Conductivity; Excitatory Amino Acids; Female; Glutamic Acid; Humans; Ion Channel Gating; Ion Channels; Oocytes; Patch-Clamp Techniques; Thermodynamics; Transfection; Xenopus | 1995 |
Recognition system for dietary fatty acids in the rat small intestine.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Dietary Fats; Gastrointestinal Hormones; Glutamic Acid; Intestinal Mucosa; Intestine, Small; Linoleic Acid; Linoleic Acids; Oleic Acid; Oleic Acids; Pancreas; Rats; Receptors, N-Methyl-D-Aspartate | 1995 |
Cocaine increases extraneuronal levels of aspartate and glutamate in the nucleus accumbens.
Topics: Analysis of Variance; Animals; Aspartic Acid; Behavior, Animal; Calcium; Cocaine; Dose-Response Relationship, Drug; Glutamic Acid; Male; Microdialysis; Narcotics; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin | 1995 |
The functional role of the binding site aspartate in muscarinic acetylcholine receptors, probed by site-directed mutagenesis.
Topics: Acetylcholine; Animals; Aspartic Acid; Binding Sites; CHO Cells; Cloning, Molecular; Cricetinae; Glutamic Acid; GTP-Binding Proteins; Ligands; Muscarinic Agonists; Mutagenesis, Site-Directed; Phosphatidylinositols; Receptors, Muscarinic | 1995 |
Intracellular acidification and Ca2+ transients in cultured rat cerebellar astrocytes evoked by glutamate agonists and noradrenaline.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Calcium; Cells, Cultured; Cerebellum; Cycloleucine; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Fura-2; Glutamic Acid; Hydrogen-Ion Concentration; Kainic Acid; Neurotoxins; Norepinephrine; Rats; Receptors, Metabotropic Glutamate | 1995 |
Mutations in motif II of Escherichia coli DNA helicase II render the enzyme nonfunctional in both mismatch repair and excision repair with differential effects on the unwinding reaction.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; Aspartic Acid; Base Sequence; DNA; DNA Helicases; DNA Repair; DNA, Single-Stranded; Escherichia coli; Escherichia coli Proteins; Genes, Dominant; Glutamic Acid; Kinetics; Molecular Sequence Data; Mutation; Phenotype; Sequence Deletion; Ultraviolet Rays | 1995 |
High-resolution structure of the catalytic domain of avian sarcoma virus integrase.
Topics: Amino Acid Sequence; Aspartic Acid; Avian Sarcoma Viruses; Bacterial Proteins; Binding Sites; Crystallization; Crystallography, X-Ray; DNA Nucleotidyltransferases; Endodeoxyribonucleases; Escherichia coli Proteins; Glutamic Acid; HIV; Integrases; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Protein Folding; Protein Structure, Secondary; Ribonuclease H; Sequence Homology, Amino Acid; Virus Integration | 1995 |
Noradrenaline-induced stimulation of glutamine metabolism in primary cultures of astrocytes.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Aspartic Acid; Astrocytes; Carbon Dioxide; Cells, Cultured; Glutamic Acid; Glutamine; Mice; Norepinephrine; Time Factors | 1995 |
Cone photoreceptors respond to their own glutamate release in the tiger salamander.
Topics: Ambystoma; Animals; Aspartic Acid; Calcium; Chloride Channels; Exocytosis; Fluorescent Dyes; Fura-2; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Ion Channel Gating; Kainic Acid; Membrane Potentials; Patch-Clamp Techniques; Picrotoxin; Retinal Cone Photoreceptor Cells; Synapses; Synaptic Transmission; Time Factors | 1995 |
Mutation of conserved negatively charged residues in the S2 and S3 transmembrane segments of a mammalian K+ channel selectively modulates channel gating.
Topics: Amino Acid Sequence; Animals; Arginine; Aspartic Acid; Brain; Conserved Sequence; Female; Glutamic Acid; Ion Channel Gating; Kinetics; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Potassium Channels; Protein Structure, Secondary; Recombinant Proteins; Threonine; Xenopus laevis | 1995 |
Inhibitory and excitatory amino acids in cerebrospinal fluid of neurolathyrism patients, a highly prevalent motorneurone disease.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Eating; Excitatory Amino Acids; Fabaceae; Glutamic Acid; Glycine; Humans; Isoleucine; Middle Aged; Motor Neuron Disease; Neurotoxins; Plants, Medicinal; Taurine; Threonine | 1995 |
NMDA-induced glutamate and aspartate release from rat cortical pyramidal neurones: evidence for modulation by a 5-HT1A antagonist.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Drug Synergism; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Molecular Probes; N-Methylaspartate; Piperazines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists | 1995 |
Glutamic acid 204 is the terminal proton release group at the extracellular surface of bacteriorhodopsin.
Topics: Aspartic Acid; Bacteriorhodopsins; Binding Sites; Cell Membrane; Glutamic Acid; Halobacterium; Hydrogen Bonding; Kinetics; Molecular Structure; Photochemistry; Point Mutation; Protons; Schiff Bases; Spectroscopy, Fourier Transform Infrared; Water | 1995 |
Blood urea and amino acid concentrations in pigs of two breed combinations as affected by energy intakes.
Topics: Amino Acids; Animals; Aspartic Acid; Blood Urea Nitrogen; Chromatography, High Pressure Liquid; Crosses, Genetic; Diet; Energy Intake; Energy Metabolism; Glutamic Acid; Histidine; Lysine; Male; Swine; Tyrosine; Weight Gain | 1995 |
In vivo release of neuroactive amino acids from the inferior colliculus of the guinea pig using brain microdialysis.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Aspartic Acid; Blood-Brain Barrier; Calcium; Calibration; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Guinea Pigs; Inferior Colliculi; Injections, Intravenous; Male; Microdialysis; Potassium; Synaptic Transmission | 1995 |
Profound systemic hypothermia inhibits the release of neurotransmitter amino acids in spinal cord ischemia.
Topics: Analysis of Variance; Animals; Aspartic Acid; Cardiopulmonary Bypass; Disease Models, Animal; Evoked Potentials, Somatosensory; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hypothermia, Induced; Ischemia; Microdialysis; Neurotransmitter Agents; Spinal Cord; Swine; Thoracotomy | 1995 |
Extracellular glutamate flux regulates intracellular glutaminase activity in LLC-PK1-F+ cells.
Topics: Animals; Aspartic Acid; Cell Line; Extracellular Space; gamma-Glutamyltransferase; Glutamic Acid; Glutaminase; Glutamine; Intracellular Fluid; Isoxazoles; Kidney Tubules, Proximal; Kinetics; LLC-PK1 Cells; Models, Biological; Swine | 1995 |
Retinal neurones specific for centrifugal modulation of vision.
Topics: Animals; Aspartic Acid; Coturnix; Dendrites; Glutamic Acid; Immunohistochemistry; Isoquinolines; Male; Nerve Endings; Nerve Fibers; Neurons; Optic Nerve; Retina; Retinal Ganglion Cells; Vision, Ocular; Visual Pathways | 1995 |
Effects of D-amphetamine administration on the release of endogenous excitatory amino acids in the rat nucleus accumbens.
Topics: Amphetamine; Animals; Aspartic Acid; Excitatory Amino Acids; Glutamic Acid; Haloperidol; Injections, Intravenous; Male; N-Methylaspartate; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1995 |
Blockers of NMDA-operated channels decrease glutamate and aspartate extracellular accumulation in striatum during forebrain ischaemia in rats.
Topics: Animals; Aspartic Acid; Brain Ischemia; Calcium; Corpus Striatum; Dizocilpine Maleate; Glutamic Acid; Magnesium; Male; Microdialysis; Prosencephalon; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1995 |
Isolation and partial characterization of rat sperm tail fibrous sheath proteins and comparison with rabbit and human spermatozoa using a polyclonal antiserum.
Topics: Animals; Aspartic Acid; Blotting, Western; Cystine; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Glutamic Acid; Glycine; Humans; Immune Sera; Leucine; Male; Microscopy, Electron; Proteins; Rabbits; Rats; Rats, Sprague-Dawley; Serine; Sperm Tail | 1995 |
Identification of four acidic amino acids that constitute the catalytic center of the RuvC Holliday junction resolvase.
Topics: Aspartic Acid; Bacterial Proteins; Base Sequence; Binding Sites; Catalysis; DNA, Bacterial; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Genetic Complementation Test; Glutamic Acid; Magnesium; Manganese; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenotype; Protein Conformation; Recombination, Genetic; Ribonuclease H | 1995 |
Astrocytes as potential modulators of mercuric chloride neurotoxicity.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biological Transport; Brain; Calcium Channels; Cells, Cultured; Dithiothreitol; Dose-Response Relationship, Drug; Glutamic Acid; Glutathione; Kinetics; Mercuric Chloride; Nimodipine; Rats; Rats, Sprague-Dawley; Time Factors | 1994 |
Age-dependent neurotoxicity of striatal lesions produced by aminooxyacetic acid: quantitative in vitro 1H NMR spectroscopic studies.
Topics: Aging; Alanine; Animals; Aspartic Acid; Corpus Striatum; Creatine; Energy Metabolism; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; In Vitro Techniques; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Mitochondria; Rats; Rats, Sprague-Dawley | 1995 |
Effect of amygdaloid kindling on the content and release of amino acids from the amygdaloid complex: in vivo and in vitro studies.
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Cerebral Cortex; Dialysis; Electric Stimulation; Glutamic Acid; Glutamine; Hippocampus; In Vitro Techniques; Kindling, Neurologic; Male; Potassium Chloride; Rats; Rats, Sprague-Dawley; Seizures | 1995 |
Evidence for a glutamatergic pathway from the guinea pig auditory cortex to the inferior colliculus.
Topics: Aspartic Acid; Auditory Cortex; Calcium; Carbon Radioisotopes; Electric Stimulation; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inferior Colliculi; Male; Nerve Degeneration; Nerve Fibers; Neural Pathways; Tritium | 1995 |
Changes in amino acid release and membrane potential during cerebral hypoxia and glucose deprivation.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Glucose; Glutamic Acid; Hippocampus; Hypoxia, Brain; Membrane Potentials; Rats; Rats, Wistar; Time Factors | 1995 |
Involvement of P-type calcium channels in high potassium-elicited release of neurotransmitters from rat brain slices.
Topics: Analysis of Variance; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Calcium Channels; Corpus Striatum; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Neurotransmitter Agents; Nifedipine; Norepinephrine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Potassium; Rats; Rats, Wistar; Serotonin; Spider Venoms | 1995 |
Effect of biotin on ammonia intoxication in rats and mice.
Topics: Acetates; Amino Acids; Ammonia; Analysis of Variance; Animals; Aspartic Acid; Biotin; Brain; Dipeptides; Glutamic Acid; Glutamine; Male; Mice; Mice, Inbred Strains; Rats; Rats, Sprague-Dawley | 1995 |
Isolation and identification of two potent neurotoxins, aspartic acid and glutamic acid, from yellow star thistle (Centaurea solstitialis).
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamic Acid; Mice; Neurotoxins; Plant Extracts; Plants, Toxic | 1995 |
Convergent evolution of amino acid usage in archaebacterial and eubacterial lineages adapted to high salt.
Topics: Archaea; Arginine; Aspartic Acid; Bacterial Proteins; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Escherichia coli; Eubacterium; Glutamic Acid; In Vitro Techniques; Lysine; Oceans and Seas; Sodium Chloride | 1995 |
Induction of the high-affinity Na(+)-dependent glutamate transport system XAG- by hypertonic stress in the renal epithelial cell line NBL-1.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Cattle; Cell Line; Cycloheximide; Demecolcine; Epithelium; Gene Expression; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hypertonic Solutions; Kidney; Kinetics; RNA, Messenger; Stress, Physiological; Symporters; Time Factors; Tunicamycin | 1995 |
Uptake and metabolism of delta 1-piperidine-2-carboxylic acid by synaptosomes from rat cerebral cortex.
Topics: Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamic Acid; Kinetics; Lysine; Male; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Synaptosomes | 1995 |
Kinetic and energetic characterization of solute flux through the reconstituted aspartate/glutamate carrier from beef heart mitochondria after modification with mercurials.
Topics: Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Biological Transport; Carrier Proteins; Cattle; Glutamic Acid; Kinetics; Mersalyl; Mitochondria, Heart; Mitochondrial ADP, ATP Translocases; Permeability; Temperature | 1995 |
5-Hydroxytryptamine3 receptor modulation of excitatory amino acid release in the rat nucleus tractus solitarius.
Topics: Animals; Aspartic Acid; Biguanides; Excitatory Amino Acids; Glutamic Acid; Hypoglycemic Agents; In Vitro Techniques; Male; Microdialysis; Ondansetron; Rats; Rats, Inbred WKY; Receptors, Serotonin; Solitary Nucleus | 1995 |
The glutamate uptake regulatory protein (Grp) of Zymomonas mobilis and its relation to the global regulator Lrp of Escherichia coli.
Topics: Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Base Sequence; Biological Transport; Carrier Proteins; Cloning, Molecular; DNA-Binding Proteins; Escherichia coli; Escherichia coli Proteins; Gene Dosage; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genes, Regulator; Genetic Complementation Test; Glutamic Acid; Leucine-Responsive Regulatory Protein; Molecular Sequence Data; Operon; Regulon; Restriction Mapping; Sequence Homology, Amino Acid; Symporters; Transcription Factors; Zymomonas | 1995 |
Effects of a glutamate uptake inhibitor on glutamate release induced by veratridine and ischemia.
Topics: Animals; Anti-Bacterial Agents; Aspartic Acid; Brain Ischemia; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Microdialysis; Neurotransmitter Uptake Inhibitors; Rats; Rats, Wistar; Veratridine | 1995 |
Amino acid immunoreactivity in corticospinal terminals.
Topics: Amino Acids; Animals; Aspartic Acid; Axons; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Horseradish Peroxidase; Immunohistochemistry; Male; Microscopy, Electron; Mitochondria; Nerve Endings; Rats; Rats, Sprague-Dawley; Spinal Cord; Tissue Embedding; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Wheat Germ Agglutinins | 1993 |
Capsaicin inhibits whereas rhizotomy potentiates substance P-induced release of excitatory amino acids in the rat spinal cord in vivo.
Topics: Animals; Aspartic Acid; Capsaicin; Glutamates; Glutamic Acid; Male; Rats; Rats, Sprague-Dawley; Reference Values; Spinal Cord; Spinal Nerves; Substance P | 1993 |
Glutamate dehydrogenase improves binding of [3H]CGP39653 to NMDA receptors in the autoradiographic assay.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Brain; Brain Chemistry; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1993 |
Neurotransmitter receptors and voltage-dependent Ca2+ channels encoded by mRNA from the adult corpus callosum.
Topics: Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antisense Elements (Genetics); Aspartic Acid; Astrocytes; Biomarkers; Calcium Channels; Cattle; Corpus Callosum; Female; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Glycine; Humans; Ibotenic Acid; In Situ Hybridization; Kainic Acid; Male; Membrane Potentials; Middle Aged; Oocytes; Quisqualic Acid; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter; RNA Probes; RNA, Messenger; Xenopus | 1993 |
Galanin reduces release of endogenous excitatory amino acids in the rat hippocampus.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Galanin; Glutamates; Glutamic Acid; Glyburide; Hippocampus; In Vitro Techniques; Male; Peptide Fragments; Peptides; Potassium; Potassium Channels; Rats; Rats, Wistar; Regression Analysis; Substance P | 1993 |
Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Aspartic Acid; Blood Pressure; Corpus Striatum; Glutamates; Glutamic Acid; Ischemic Attack, Transient; Kinetics; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Potassium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Aspartate and glutamate mediate excitatory synaptic transmission in area CA1 of the hippocampus.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Calcium; Evoked Potentials; Glucose; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neurons; Pipecolic Acids; Pyramidal Tracts; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Tritium | 1993 |
Modulation of calcium-dependent and -independent components of veratridine-evoked release of glutamate from rat cerebellum.
Topics: Amiloride; Animals; Apamin; Aspartic Acid; Calcium; Calcium Channel Blockers; Cerebellum; Cobalt; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; omega-Conotoxins; Peptides; Perfusion; Rats; Rats, Wistar; Ruthenium Red; Tetrodotoxin; Verapamil; Veratridine | 1993 |
Amino acid neurotransmitters in alcohol withdrawal.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Amino Acids; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Male; Neurologic Examination | 1994 |
Huntington's disease: the neuroexcitotoxin aspartate is increased in platelets and decreased in plasma.
Topics: Adult; Aspartic Acid; Blood Platelets; Blood Proteins; Chromatography, High Pressure Liquid; Female; Glutamic Acid; Glutamine; Humans; Huntington Disease; Male; Middle Aged; Phenylalanine; Plasma | 1994 |
Glu-50 in the catalytic chain of Escherichia coli aspartate transcarbamoylase plays a crucial role in the stability of the R quaternary structure.
Topics: Alanine; Allosteric Regulation; Allosteric Site; Aspartate Carbamoyltransferase; Aspartic Acid; Enzyme Activation; Enzyme Stability; Escherichia coli; Glutamic Acid; Kinetics; Nucleotides; Phosphonoacetic Acid; Point Mutation; Protein Conformation; Scattering, Radiation; Succinates; Succinic Acid; X-Rays | 1994 |
Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; CD8-Positive T-Lymphocytes; Cell Line; Conserved Sequence; Cytotoxicity, Immunologic; DNA Primers; Genetic Variation; Genome, Viral; Glutamic Acid; Hepacivirus; Hepatitis C; Humans; Liver; Molecular Sequence Data; Pan troglodytes; Point Mutation; Polymerase Chain Reaction; T-Lymphocytes, Cytotoxic; Viral Nonstructural Proteins | 1995 |
Differences in amino acid content of preimplantation mouse embryos that develop in vitro versus in vivo: in vitro effects of five amino acids that are abundant in oviductal secretions.
Topics: Amino Acids; Animals; Aspartic Acid; Blastocyst; Culture Media; Embryonic and Fetal Development; Fallopian Tubes; Female; Gestational Age; Glutamic Acid; Glutamine; In Vitro Techniques; Mice; Mice, Inbred ICR; Pregnancy | 1995 |
Astrocytic swelling due to hypotonic or high K+ medium causes inhibition of glutamate and aspartate uptake and increases their release.
Topics: Animals; Aspartic Acid; Astrocytes; Brain; Brain Edema; Brain Ischemia; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypotonic Solutions; Potassium; Rats; Temperature | 1995 |
The effect of ion pairs on the thermal stability of D-glyceraldehyde 3-phosphate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima.
Topics: Amino Acid Sequence; Arginine; Aspartic Acid; Base Sequence; Enzyme Stability; Glutamic Acid; Glyceraldehyde-3-Phosphate Dehydrogenases; Gram-Negative Anaerobic Bacteria; Hot Temperature; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Sequence Alignment | 1994 |
Variant forms of neuronal glutamate transporter sites in Alzheimer's disease cerebral cortex.
Topics: Aged; Alzheimer Disease; Amino Acid Transport System X-AG; Aspartic Acid; ATP-Binding Cassette Transporters; Binding Sites; Cerebral Cortex; Cysteic Acid; Female; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Neurons; Synaptic Membranes; Tissue Distribution; Tritium | 1995 |
Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats.
Topics: Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Dinoprostone; Formaldehyde; Glutamic Acid; Hindlimb; Ibuprofen; Injections, Spinal; Male; Microdialysis; Pain; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors | 1995 |
Enzymatic and metabolic studies on retrograde regulation mutants of yeast.
Topics: Acetate-CoA Ligase; Aspartic Acid; Citrate (si)-Synthase; Fumarate Hydratase; Gene Expression Regulation, Fungal; Genes, Fungal; Glutamic Acid; Isocitrate Dehydrogenase; Malate Dehydrogenase; Mitochondria; Mutagenesis; Oxygen Consumption; Pyruvate Carboxylase; Saccharomyces cerevisiae; Species Specificity; Succinate Dehydrogenase | 1995 |
Amino acid residues that influence the binding of manganese or calcium to photosystem II. 1. The lumenal interhelical domains of the D1 polypeptide.
Topics: Amino Acids; Aspartic Acid; Calcium; Cyanobacteria; Electron Transport; Glutamic Acid; Histidine; Light; Light-Harvesting Protein Complexes; Manganese; Mutagenesis, Site-Directed; Photochemistry; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Plastoquinone; Protein Structure, Secondary; Spectrometry, Fluorescence; Structure-Activity Relationship; Tyrosine | 1995 |
Amino acid residues that influence the binding of manganese or calcium to photosystem II. 2. The carboxy-terminal domain of the D1 polypeptide.
Topics: Amino Acids; Aspartic Acid; Calcium; Chlorophyll; Chlorophyll A; Cyanobacteria; Electron Transport; Glutamic Acid; Histidine; Kinetics; Light; Light-Harvesting Protein Complexes; Manganese; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxygen; Peptide Fragments; Photochemistry; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Plastoquinone; Structure-Activity Relationship; Water | 1995 |
A study of binary complexes of Escherichia coli maltodextrin phosphorylase: alpha-D-glucose 1-methylenephosphonate as a probe of pyridoxal 5'-phosphate-substrate interactions.
Topics: Aspartic Acid; Binding Sites; Binding, Competitive; Escherichia coli; Glucose; Glucosyltransferases; Glutamic Acid; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Organophosphorus Compounds; Protein Conformation; Pyridoxal Phosphate | 1995 |
Mutagenesis of the putative alpha-helical domain of the Vpr protein of human immunodeficiency virus type 1: effect on stability and virion incorporation.
Topics: Amino Acid Sequence; Aspartic Acid; Drug Stability; Gene Products, vpr; Genes, vpr; Glutamic Acid; HeLa Cells; HIV-1; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Recombinant Proteins; Transfection; Virion; vpr Gene Products, Human Immunodeficiency Virus | 1995 |
Assay of blood and tissue oxaloacetate and alpha-ketoglutarate by isotope dilution gas chromatography-mass spectrometry.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Chromatography; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Isotope Labeling; Ketoglutaric Acids; Liver; Male; Oxaloacetates; Rats; Rats, Sprague-Dawley; Reference Standards | 1995 |
An in vitro 1H nuclear magnetic resonance study of the temporoparietal cortex of Alzheimer brains.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Creatinine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurofibrillary Tangles; Parietal Lobe; Temporal Lobe; Tomography, Emission-Computed, Single-Photon | 1995 |
Haloperidol reduces K(+)-evoked Ca(2+)-dependent D-[3H]aspartate release from rat hippocampal slices.
Topics: Animals; Aspartic Acid; Calcium; Glutamic Acid; Haloperidol; Hippocampus; In Vitro Techniques; Male; Potassium; Rats; Rats, Wistar; Synaptic Transmission; Tritium | 1995 |
Yeast N-terminal amidase. A new enzyme and component of the N-end rule pathway.
Topics: Acyltransferases; Amidohydrolases; Amino Acid Sequence; Amino Acids; Aminoacyltransferases; Asparagine; Aspartic Acid; Base Sequence; Carbohydrate Sequence; Cloning, Molecular; Codon; Fungal Proteins; Genes, Fungal; Glutamic Acid; Glutamine; Half-Life; Ligases; Models, Molecular; Molecular Sequence Data; Multienzyme Complexes; Promoter Regions, Genetic; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ubiquitin-Protein Ligases | 1995 |
Effect of branched-chain amino acids on glutamate metabolism in amyotrophic lateral sclerosis.
Topics: Adult; Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamic Acid; Humans; Male; Middle Aged | 1995 |
A possible role for phospholipases in the release of neurotransmitter amino acids from ischemic rat cerebral cortex.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Phospholipases; Rats; Rats, Sprague-Dawley | 1995 |
Glucose deprivation increases aspartic acid release from synaptosomes of aged mice.
Topics: Age Factors; Aging; Animals; Aspartic Acid; Brain; Energy Metabolism; Female; Glucose; Glutamic Acid; Mice; Synaptosomes | 1995 |
Modulation of D-[2,3 3H]aspartate release from rat forebrain slices by non-NMDA receptor agonists and antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Kynurenic Acid; Male; Prosencephalon; Quinoxalines; Rats; Rats, Wistar; Tritium | 1995 |
Human cytomegalovirus proteinase: candidate glutamic acid identified as third member of putative active-site triad.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Cytomegalovirus; Endopeptidases; Glutamic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Serine Endopeptidases | 1995 |
Differing protection with aspartate and glutamate cardioplegia in the isolated rat heart.
Topics: Adenine Nucleotides; Animals; Aspartic Acid; Cardioplegic Solutions; Drug Therapy, Combination; Glutamic Acid; Heart Arrest, Induced; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar | 1995 |
Effects of in vitro ethanol and chronic ethanol consumption on the release of excitatory amino acids in the rat hippocampus.
Topics: Alcohol Drinking; Animals; Aspartic Acid; Ethanol; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Changes in extracellular levels of glutamate and aspartate in rat substantia nigra induced by dopamine receptor ligands: in vivo microdialysis studies.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Aspartic Acid; Benzazepines; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Ergolines; Extracellular Space; Glutamic Acid; Kinetics; Ligands; Male; Microdialysis; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Spiperone; Substantia Nigra; Tetrodotoxin; Time Factors | 1995 |
Changes in N-acetyl-aspartate content during focal and global brain ischemia of the rat.
Topics: Animals; Aspartic Acid; Brain; Drug Stability; Glutamic Acid; Ischemic Attack, Transient; Kinetics; Male; Neurons; Postmortem Changes; Rats; Rats, Wistar | 1995 |
Deletion and site-directed mutagenesis of EF-hand domain of phospholipase C-delta 1: effects on its activity.
Topics: Alanine; Amino Acid Sequence; Animals; Aspartic Acid; CHO Cells; Cloning, Molecular; Cricetinae; Escherichia coli; Glutamic Acid; Isoenzymes; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Point Mutation; Recombinant Proteins; Sequence Deletion; Transfection | 1995 |
Interpreting the effects of specific protein modification on antiport coupling mechanisms: the case of the aspartate/glutamate exchanger.
Topics: Antiporters; Aspartic Acid; Biological Transport; Glutamic Acid; Mitochondria; Models, Chemical; Protein Conformation; Substrate Specificity; Sulfhydryl Compounds | 1995 |
Paraquat--a superoxide generator--kills neurons in the rat spinal cord.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Cell Death; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Microdialysis; Neurons; Neurotoxins; Paraquat; Rats; Rats, Sprague-Dawley; Spinal Cord; Superoxides; Synapses; Time Factors | 1995 |
Glucose metabolism in the developing cerebral cortex as detected by 1H(13C) nuclear magnetic resonance spectroscopy ex vivo.
Topics: Acetates; Animals; Aspartic Acid; Carbon Isotopes; Cerebral Cortex; Female; Glucose; Glutamic Acid; Hydrogen; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Oxygen; Rats | 1995 |
Hemoglobin Roanne [alpha 94(G1) Asp-->Glu]: a variant of the alpha 1 beta 2 interface with an unexpected high oxygen affinity.
Topics: Aged; Aspartic Acid; Binding Sites; Carbon Monoxide; Female; Glutamic Acid; Hemoglobins, Abnormal; Humans; Hydrogen Bonding; Isoelectric Focusing; Kinetics; Mass Spectrometry; Molecular Structure; Oxygen; Structure-Activity Relationship | 1995 |
Site-specificity of the second-site suppressor mutation of the Asp-285-->Asn mutant of metal-tetracycline/H+ antiporter of Escherichia coli and the effects of amino acid substitutions at the first and second sites.
Topics: Amino Acid Sequence; Antiporters; Asparagine; Aspartic Acid; Bacterial Proteins; Biological Transport; Escherichia coli; Glutamic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Structure-Activity Relationship; Suppression, Genetic; Tetracycline | 1995 |
Release of glutamate from striatum of freely moving rats by pros-methylimidazoleacetic acid.
Topics: Animals; Aspartic Acid; Carbon; Carbon Radioisotopes; Corpus Striatum; Glutamic Acid; Imidazoles; In Vitro Techniques; Male; Motor Activity; Rats; Rats, Wistar; Veratridine | 1995 |
Action of trimetazidine on retina of gerbils after ischemia reperfusion insult: determination of .OH, amino acids, and electroretinogram.
Topics: Amino Acids; Animals; Aspartic Acid; Electroretinography; Female; gamma-Aminobutyric Acid; Gentisates; Gerbillinae; Glutamic Acid; Hydroxybenzoates; Hydroxyl Radical; Ischemia; Male; Reperfusion Injury; Retina; Retinal Vessels; Trimetazidine | 1994 |
Catalytic-rate improvement of a thermostable malate dehydrogenase by a subtle alteration in cofactor binding.
Topics: Aspartic Acid; Base Sequence; Catalysis; Enzyme Stability; Glutamic Acid; Hot Temperature; Malate Dehydrogenase; Models, Chemical; Molecular Sequence Data; Mutagenesis; Mutation; NAD; Oxaloacetates; Oxidation-Reduction; Protein Conformation; Recombinant Proteins; Solvents; Structure-Activity Relationship; Thermus; Viscosity | 1995 |
[Effects of electrical stimulation of S II and electroacupuncture on contents of some free amino acids in the precruciate cortex].
Topics: Animals; Aspartic Acid; Cats; Cerebral Cortex; Electric Stimulation; Electroacupuncture; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Random Allocation; Somatosensory Cortex | 1994 |
1H-2H exchange in the perfused rat liver metabolizing [3-13C]alanine and 2H2O as detected by multinuclear NMR spectroscopy.
Topics: Alanine; Animals; Aspartic Acid; Carbon Isotopes; Deuterium; Deuterium Oxide; Glutamic Acid; Hydrogen; Liver; Magnetic Resonance Spectroscopy; Male; Perfusion; Rats; Rats, Sprague-Dawley | 1994 |
Comparison of the superfused efflux of preaccumulated D-[3H]aspartate and endogenous L-aspartate and L-glutamate from rat cerebrocortical minislices.
Topics: Animals; Aspartic Acid; Biological Transport; Calcium; Cerebral Cortex; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Potassium; Quinoxalines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tetrodotoxin | 1994 |
Cold lability of the mutant forms of Escherichia coli inorganic pyrophosphatase.
Topics: Aspartic Acid; Binding Sites; Cold Temperature; Escherichia coli; Glutamic Acid; Glutamine; Histidine; Kinetics; Macromolecular Substances; Magnesium; Mutagenesis, Site-Directed; Pyrophosphatases; Structure-Activity Relationship | 1995 |
Crystal structure and site-directed mutagenesis of Bacillus macerans endo-1,3-1,4-beta-glucanase.
Topics: Amino Acid Sequence; Aspartic Acid; Bacillus; Base Sequence; Binding Sites; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Glutamic Acid; Glycoside Hydrolases; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins; Tryptophan | 1995 |
Resuscitative retrograde blood cardioplegia. Are amino acids or continuous warm techniques necessary?
Topics: Animals; Aspartic Acid; Blood; Cardioplegic Solutions; Dogs; Glutamic Acid; Heart Arrest, Induced; Myocardial Contraction; Myocardial Stunning; Resuscitation; Stroke Volume; Temperature; Ventricular Function, Left | 1995 |
Calcium channel antagonist peptides define several components of transmitter release in the hippocampus.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Calcium Channel Blockers; Calcium Channels; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Molecular Sequence Data; Neurotransmitter Agents; Norepinephrine; omega-Conotoxins; Peptides; Rats; Rats, Sprague-Dawley | 1994 |
Presence of free D-glutamate and D-aspartate in rat tissues.
Topics: Amino Acid Oxidoreductases; Animals; Aspartic Acid; Brain; D-Aspartate Oxidase; Female; Glutamic Acid; Kidney; Liver; Male; Rats; Rats, Wistar; Sex Factors | 1995 |
Calcium-dependent activation of protein C by thrombin/thrombomudulin: role of negatively charged amino acids within the activation peptide of protein C.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Calcium; Cell Line, Transformed; Cells, Cultured; Chemical Phenomena; Chemistry, Physical; Endothelium, Vascular; Enzyme Activation; Glutamic Acid; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein C; Protein Conformation; Recombinant Fusion Proteins; Thrombin; Thrombomodulin | 1994 |
Release of glutamate and aspartate from CA1 synaptosomes: selective modulation of aspartate release by ionotropic glutamate receptor ligands.
Topics: Animals; Aspartic Acid; Calcium; Female; Glutamic Acid; Hippocampus; Ligands; Potassium; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1995 |
Simultaneous single-cell recording and microdialysis within the same brain site in freely behaving rats: a novel neurobiological method.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Electroencephalography; Electrophysiology; Glutamic Acid; Male; Microdialysis; Neurobiology; Neurons; Rats; Sleep; Stereotaxic Techniques | 1994 |
Continuous in vivo monitoring of amino acid neurotransmitters by microdialysis sampling with on-line derivatization and capillary electrophoresis separation.
Topics: Animals; Aspartic Acid; Biosensing Techniques; Brain Chemistry; Electrophoresis; Glutamic Acid; Male; Microdialysis; Rats; Rats, Sprague-Dawley | 1995 |
Characterization of a binding protein-dependent glutamate transport system of Rhodobacter sphaeroides.
Topics: Adenosine Triphosphate; Aspartic Acid; Biological Transport; Carrier Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Rhodobacter sphaeroides; Substrate Specificity; Vanadates | 1995 |
Protein synthesis and energy metabolism in hippocampal slices during extended (24 hours) recovery following different periods of ischemia.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain Ischemia; Energy Metabolism; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Nerve Tissue Proteins; Rats | 1994 |
Transmitter amino acid release from rat neocortex: complete versus incomplete ischemia models.
Topics: Animals; Aspartic Acid; Blood Pressure; Cerebral Cortex; Chromatography, High Pressure Liquid; Extracellular Space; Functional Laterality; gamma-Aminobutyric Acid; Glutamic Acid; Ischemic Attack, Transient; Male; Rats; Rats, Sprague-Dawley; Reperfusion | 1994 |
Activity-dependent plasticity of inhibitory and excitatory amino acid transmitter systems in cultured rat cerebral cortex.
Topics: Animals; Aspartic Acid; Biomarkers; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Nerve Tissue Proteins; Neuroglia; Neuronal Plasticity; Neurotransmitter Agents; Phosphopyruvate Hydratase; Rats; Tetrodotoxin | 1994 |
Metabolic flux determination in C6 glioma cells using carbon-13 distribution upon [1-13C]glucose incubation.
Topics: Alanine; Aspartic Acid; Carbon Isotopes; Citric Acid Cycle; Glioma; Gluconeogenesis; Glucose; Glutamates; Glutamic Acid; Glycogen; Glycolysis; Kinetics; Magnetic Resonance Spectroscopy; Malate Dehydrogenase; Mathematics; Models, Biological; Pentose Phosphate Pathway; Perchlorates; Pyruvates; Pyruvic Acid; Tumor Cells, Cultured | 1993 |
Site-directed mutagenesis of histidine 93, aspartic acid 180, glutamic acid 205, histidine 290, and aspartic acid 291 at the active site and tryptophan 279 at the raw starch binding site in barley alpha-amylase 1.
Topics: alpha-Amylases; Amino Acid Sequence; Aspartic Acid; Base Sequence; Binding Sites; Cloning, Molecular; DNA Primers; Glutamates; Glutamic Acid; Histidine; Hordeum; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Recombinant Proteins; Saccharomyces cerevisiae; Tryptophan | 1993 |
Effect of glutamine on heat-shock-induced mRNA and stress proteins.
Topics: Ammonium Chloride; Animals; Aspartic Acid; Blotting, Northern; Cell Line; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Glutamine; Heat-Shock Proteins; Hot Temperature; Kidney; L-Lactate Dehydrogenase; Opossums; Quaternary Ammonium Compounds; RNA, Messenger; Time Factors; Transcription, Genetic | 1993 |
(2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate.
Topics: Amino Acids, Dicarboxylic; Animals; Anti-Bacterial Agents; Asparagine; Aspartic Acid; Astrocytes; Cell Membrane; Cells, Cultured; Depression, Chemical; Female; Glutamates; Glutamic Acid; Hippocampus; Kinetics; Neuroglia; Neurons; Pregnancy; Rats; Rats, Wistar; Stereoisomerism; Synaptosomes | 1993 |
The pyrimidine-derivative, BW1003C87, protects CA1 and striatal neurons following transient severe forebrain ischaemia in rats. A microdialysis and histological study.
Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Male; Microdialysis; Neurons; Prosencephalon; Pyramidal Tracts; Pyrimidines; Rats; Rats, Wistar; Taurine; Time Factors | 1993 |
Effect of experimental Escherichia coli meningitis on concentrations of excitatory and inhibitory amino acids in the rabbit brain: in vivo microdialysis study.
Topics: Amino Acids; Animals; Aspartic Acid; Blood Pressure; Brain; Cerebrovascular Circulation; Disease Models, Animal; Escherichia coli Infections; Extracellular Space; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Meningitis, Bacterial; Microdialysis; Neurotransmitter Agents; Rabbits; Taurine | 1993 |
Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Cell Line; Glutamates; Glutamic Acid; Glutamine; Kinetics; Light; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Proteins; Retinaldehyde; Rhodopsin; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Time Factors; Transfection | 1993 |
Digestibility and amino acid composition of digesta at the end of the ileum in preruminant calves fed soyabean protein.
Topics: Amino Acids; Animals; Aspartic Acid; Cattle; Dietary Proteins; Digestion; Glutamates; Glutamic Acid; Ileum; Plant Proteins, Dietary; Soybean Proteins | 1993 |
Ischemia-induced upregulation of excitatory amino acid transport sites.
Topics: Animals; Aspartic Acid; Binding Sites; Biological Transport; Glutamates; Glutamic Acid; Ischemic Attack, Transient; Male; Rats; Rats, Wistar; Tritium; Up-Regulation | 1993 |
Sarcoplasmic reticulum calcium ATPase. Labeling of a putative Mg2+ site by reaction with a carbodiimide and a spin-label.
Topics: Animals; Aspartic Acid; Binding Sites; Calcium; Calcium-Transporting ATPases; Cyclic N-Oxides; Egtazic Acid; Ethyldimethylaminopropyl Carbodiimide; Glutamates; Glutamic Acid; Kinetics; Magnesium; Muscles; Phosphorylation; Rabbits; Sarcoplasmic Reticulum; Spin Labels | 1993 |
Excitatory amino acid-induced phosphoinositide hydrolysis in Müller glia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Chickens; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; Kainic Acid; N-Methylaspartate; Neuroglia; Quinoxalines; Quisqualic Acid; Receptors, Amino Acid; Retina; Tritium | 1993 |
Copper(II) complexes of dipeptides containing aspartyl, glutamyl, and histidyl residues in the side chain.
Topics: Aspartic Acid; Copper; Dipeptides; Glutamates; Glutamic Acid; Histidine; Metals; Protein Binding | 1993 |
Amino acid neurotransmitters in nucleus tractus solitarius: an in vivo microdialysis study.
Topics: Afferent Pathways; Amino Acids; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Electric Stimulation; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Male; Membrane Potentials; Microdialysis; Nerve Endings; Neurotransmitter Agents; Nodose Ganglion; Potassium; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Time Factors; Vagus Nerve | 1993 |
Synaptosomal amino acid release: effect of inhibiting protein phosphatases with okadaic acid.
Topics: Amino Acids; Animals; Aspartic Acid; Cell Fractionation; Centrifugation, Density Gradient; Ethers, Cyclic; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Okadaic Acid; Phosphoprotein Phosphatases; Prosencephalon; Rats; Synaptosomes; Taurine | 1993 |
Effects of halothane on the synthesis of neurotransmitter amino acids in mouse brain.
Topics: Animals; Aspartic Acid; Brain Chemistry; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Halothane; Male; Mice | 1993 |
Cloning and expression of Geotrichum candidum lipase II gene in yeast. Probing of the enzyme active site by site-directed mutagenesis.
Topics: Aspartic Acid; Base Sequence; Binding Sites; Cloning, Molecular; DNA Mutational Analysis; DNA Primers; Geotrichum; Glutamates; Glutamic Acid; Lipase; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; Saccharomyces cerevisiae | 1993 |
Effects of diet-induced hyperthreoninemia. II). Tissue and extracellular amino acid levels in the brain.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Cerebral Cortex; Diet; Glutamates; Glutamic Acid; Glycine; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Serine; Spinal Cord; Threonine | 1994 |
Crystal structures of true enzymatic reaction intermediates: aspartate and glutamate ketimines in aspartate aminotransferase.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Chemical Phenomena; Chemistry, Physical; Chickens; Crystallization; Crystallography, X-Ray; Glutamates; Glutamic Acid; Macromolecular Substances; Mitochondria; Molecular Structure; Protein Conformation; Solutions; Spectrophotometry | 1993 |
Metabolic assessment of a neuron-enriched fraction of rat cerebrum using high-resolution 1H and 13C NMR spectroscopy.
Topics: Alanine; Animals; Aspartic Acid; Brain Chemistry; Carbon Radioisotopes; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hydrogen; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Nerve Tissue Proteins; Neurons; Rats | 1993 |
Glutamine utilization in resting and stimulated platelets.
Topics: Aspartic Acid; Blood Platelets; Carbon Dioxide; Glucose; Glutamates; Glutamic Acid; Glutamine; Humans; Oxidation-Reduction; Platelet Activation; Thrombin | 1993 |
Second-site mutation of Ala-220 to Glu or Asp suppresses the mutation of Asp-285 to Asn in the transposon Tn10-encoded metal-tetracycline/H+ antiporter of Escherichia coli.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Antiporters; Asparagine; Aspartic Acid; Bacterial Proteins; Base Sequence; Biological Transport; DNA Transposable Elements; DNA, Bacterial; Escherichia coli; Glutamates; Glutamic Acid; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Protein Structure, Secondary; Repressor Proteins; Suppression, Genetic; Tetracycline | 1993 |
rho GAP of 28 kDa (GAP2), but not of 190 kDa (p190), requires Asp65 and Asp67 of rho GTPase for its activation.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Enzyme Activation; Glutamates; Glutamic Acid; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Molecular Sequence Data; Mutation; Proteins; ras GTPase-Activating Proteins; Rats; Rho Factor; Sequence Homology, Amino Acid; Serine | 1993 |
Glucose can fuel glutamate uptake in ischemic brain.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Glucose; Glutamates; Glutamic Acid; Male; Microdialysis; Osmolar Concentration; Rats; Rats, Sprague-Dawley | 1994 |
Contrasting effects of D- and L-(E)-4-(3-phosphono-2-propenyl)piperazine-2-carboxylic acid as anticonvulsants and as inhibitors of potassium-evoked increases in hippocampal extracellular glutamate and aspartate levels in freely moving rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Extracellular Space; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Male; Microdialysis; Piperazines; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Taurine | 1994 |
On the origin of striatal cholecystokinin release: studies with in vivo microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Afferent Pathways; Animals; Aspartic Acid; Calcium; Cholecystokinin; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Glutamates; Glutamic Acid; Homovanillic Acid; Male; Microdialysis; Oxidopamine; Potassium; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Sincalide | 1994 |
Demonstration of glutamate/aspartate uptake activity in nerve endings by use of antibodies recognizing exogenous D-aspartate.
Topics: Animals; Antibodies; Aspartic Acid; Autoradiography; Glutamates; Glutamic Acid; Hippocampus; Immunohistochemistry; Isomerism; Microscopy, Electron; Nerve Endings; Rats; Rats, Wistar; Tissue Distribution | 1993 |
Lipoamide influences substrate selection in post-ischaemic perfused rat hearts.
Topics: Acetates; Acetylation; Animals; Aspartic Acid; Binding, Competitive; Carbon Isotopes; Glutamates; Glutamic Acid; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Myocardial Ischemia; Pyruvates; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Thioctic Acid | 1994 |
Lineage analysis reveals neurotransmitter (GABA or glutamate) but not calcium-binding protein homogeneity in clonally related cortical neurons.
Topics: Animals; Aspartic Acid; Calcium-Binding Proteins; Cell Line; Cerebral Cortex; Clone Cells; Epoxy Resins; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Immunohistochemistry; Neurons; Phthalic Anhydrides; Rats; Rats, Sprague-Dawley; Tissue Embedding | 1994 |
Participation of aspartic acid and pyrroloquinoline quinone in vitamin B12 production in Klebsiella pneumoniae IFO 13541.
Topics: Alanine; Amino Acids; Aspartic Acid; Culture Media; Glutamates; Glutamic Acid; Klebsiella pneumoniae; Oxidoreductases; PQQ Cofactor; Quinolones; Valine; Vitamin B 12 | 1993 |
Kinetic and mutagenic studies of the role of the active site residues Asp-50 and Glu-327 of Escherichia coli glutamine synthetase.
Topics: Adenosine Triphosphate; Aspartic Acid; Binding Sites; Escherichia coli; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Kinetics; Manganese; Models, Chemical; Mutagenesis, Site-Directed; Quaternary Ammonium Compounds | 1994 |
Depolarization elicits, while hyperpolarization blocks uptake of endogenous glutamate by retinal horizontal cells of the turtle.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Calcium; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Kainic Acid; Neurotransmitter Uptake Inhibitors; Photoreceptor Cells; Pipecolic Acids; Retina; Turtles | 1993 |
Effects of taurine on depolarization-evoked release of amino acids from rat cortical synaptosomes.
Topics: Amino Acids; Animals; Aspartic Acid; Basal Metabolism; Calcium; Cerebral Cortex; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Membrane Potentials; Neurotransmitter Agents; Potassium; Rats; Rats, Wistar; Synaptosomes; Taurine | 1993 |
[Free amino acid contents in the spinal cord of amyotrophic lateral sclerosis].
Topics: Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamates; Glutamic Acid; Humans; Male; Middle Aged; Neurotransmitter Agents; Spinal Cord | 1993 |
Brain amino acid levels are related to seizure propensity in the gerbil (Meriones unguiculatus).
Topics: Amino Acids; Analysis of Variance; Animals; Arginine; Aspartic Acid; Behavior, Animal; Brain; Citrulline; Cysteine; Disease Susceptibility; Female; Gerbillinae; Glucose; Glutamates; Glutamic Acid; Glutamine; Glycine; Male; Seizures | 1993 |
Effect of ischaemia and reperfusion on the extra- and intracellular distribution of glutamate, glutamine, aspartate and GABA in the rat hippocampus, with a note on the effect of the sodium channel blocker BW1003C87.
Topics: Animals; Aspartic Acid; Calcium Channel Blockers; Extracellular Space; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Hippocampus; Intracellular Fluid; Ischemic Attack, Transient; Male; Microdialysis; Microscopy, Immunoelectron; Neurons; Pyramidal Cells; Pyrimidines; Rats; Rats, Wistar; Reperfusion; Time Factors | 1993 |
Immunocytochemical localization of amino acid neurotransmitter candidates in the ventral horn of the cat spinal cord: a light microscopic study.
Topics: Amino Acids; Animals; Aspartic Acid; Cats; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Histological Techniques; Homocysteine; Immunohistochemistry; Motor Neurons; Neurons; Neurotransmitter Agents; Spinal Cord; Synapses; Taurine | 1993 |
L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Choline; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycoproteins; Kinetics; Mice; Neurons; Neurotransmitter Uptake Inhibitors; Sodium; Stereoisomerism | 1994 |
Excitatory amino acids as neurotransmitters of cortical and cerebellar projections to the red nucleus: an immunocytochemical study in the guinea pig.
Topics: Afferent Pathways; Animals; Aspartic Acid; Brain Mapping; Cerebellar Nuclei; Cerebellum; Cerebral Cortex; Glutamates; Glutamic Acid; Guinea Pigs; Immunoenzyme Techniques; Neurons; Red Nucleus; Synaptic Transmission | 1993 |
Na(+)-dependent high affinity uptake of L-glutamate in primary cultures of human fibroblasts isolated from three different types of tissue.
Topics: Aspartic Acid; Biological Transport; Cells, Cultured; Dicarboxylic Acids; Fibroblasts; Glutamates; Glutamic Acid; Humans; Kinetics; Muscles; Peripheral Nerves; Pyrrolidines; Skin; Sodium; Tritium | 1994 |
Glial contributions to excitatory neurotransmission in cultured hippocampal cells.
Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Cells, Cultured; Electrophysiology; Glutamates; Glutamic Acid; Glycoproteins; Hippocampus; Lithium; Neuroglia; Neurotransmitter Agents; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1994 |
Excitatory amino acids in the cerebrospinal fluid of asphyxiated infants: relationship to hypoxic-ischemic encephalopathy.
Topics: Amino Acids; Aspartic Acid; Asphyxia Neonatorum; Brain Ischemia; Child, Preschool; Chromatography, Liquid; Glutamates; Glutamic Acid; Humans; Hypoxia, Brain; Infant; Infant, Newborn; Infant, Premature; Neurotransmitter Agents; Severity of Illness Index; Taurine | 1993 |
Identification of a glutamate residue at the active site of xylanase A from Schizophyllum commune.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Carbodiimides; Chromatography, High Pressure Liquid; Endo-1,4-beta Xylanases; Glutamates; Glutamic Acid; Glycoside Hydrolases; Molecular Sequence Data; Protein Structure, Secondary; Schizophyllum; Sequence Alignment; Sequence Homology, Amino Acid; Staphylococcus | 1994 |
Improved continuum electrostatic modelling in proteins, with comparison to experiment.
Topics: Amino Acid Sequence; Aspartic Acid; Bacillus; Binding Sites; Calcium; Electrochemistry; Glutamates; Glutamic Acid; Histidine; Mathematics; Models, Molecular; Mutagenesis, Site-Directed; Osmolar Concentration; Protein Conformation; Protein Folding; Recombinant Proteins; Solvents; Subtilisins | 1994 |
Spinal cord ischemia and reperfusion metabolism: the effect of hypothermia.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Body Temperature; Combined Modality Therapy; Energy Metabolism; Glucose; Glutamates; Glutamic Acid; Heparin; Hypothermia, Induced; Intracellular Fluid; Ischemia; Lactates; Lactic Acid; Neurologic Examination; Neurotransmitter Agents; Rabbits; Reperfusion Injury; Sodium Chloride; Spinal Cord | 1994 |
Comparison between the slow cornea-negative PIII component of the ERG and potassium changes in the isolated rabbit retina.
Topics: Animals; Aspartic Acid; Carrier Proteins; Cornea; Electroretinography; Glutamates; Glutamic Acid; Interneurons; Light; Photoreceptor Cells; Potassium; Rabbits; Retina; Sodium-Bicarbonate Symporters | 1993 |
Effect of phencyclidine on endogenous excitatory amino acid release from the rat anterior cingulate cortex--an in vivo microdialysis study.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Gyrus Cinguli; Male; Microdialysis; Phencyclidine; Potassium; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1993 |
Crystal structure of the mutant yeast triosephosphate isomerase in which the catalytic base glutamic acid 165 is changed to aspartic acid.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Binding Sites; Crystallography, X-Ray; DNA Primers; Glutamates; Glutamic Acid; Ligands; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Recombinant Proteins; Saccharomyces cerevisiae; Triose-Phosphate Isomerase; X-Ray Diffraction | 1994 |
Two contiguous residues in human interleukin-3, Asp21 and Glu22, selectively interact with the alpha- and beta-chains of its receptor and participate in function.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cell Line; Cloning, Molecular; Glutamates; Glutamic Acid; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Interleukin-5; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Receptors, Interleukin-3; Restriction Mapping; Sequence Homology, Amino Acid; Threonine; Transfection | 1994 |
Colocalization of excitatory and inhibitory neurotransmitter markers in striatal projection neurons in the rat.
Topics: Animals; Aspartic Acid; Autoradiography; Biomarkers; gamma-Aminobutyric Acid; Globus Pallidus; Glutamates; Glutamic Acid; Immunohistochemistry; Injections; Neostriatum; Neural Pathways; Neurons; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Substantia Nigra; Synaptic Transmission | 1994 |
Effect of the non-NMDA receptor antagonist GYKI 52466 on the microdialysate and tissue concentrations of amino acids following transient forebrain ischaemia.
Topics: Amino Acids; Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Cerebral Cortex; Corpus Striatum; Dialysis; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Kainic Acid; Male; Neurotoxins; Prosencephalon; Rats; Rats, Wistar; Receptors, Neurotransmitter | 1994 |
Relevance of sequence statistics for the properties of extremophilic proteins.
Topics: Amino Acids; Animals; Aspartic Acid; Electrochemistry; Enzyme Stability; Glutamates; Glutamic Acid; Glyceraldehyde-3-Phosphate Dehydrogenases; Gram-Negative Anaerobic Bacteria; Halobacterium; Hot Temperature; Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thermodynamics; Thermus; Water | 1994 |
Alterations of brain metabolites in metachromatic leukodystrophy as detected by localized proton magnetic resonance spectroscopy in vivo.
Topics: Adolescent; Aspartic Acid; Bone Marrow Transplantation; Brain; Brain Chemistry; Child; Child, Preschool; Choline; Creatine; Female; Glutamates; Glutamic Acid; Humans; Inositol; Lactates; Lactic Acid; Leukodystrophy, Metachromatic; Magnetic Resonance Imaging; Male; Phosphocreatine; Postoperative Period | 1993 |
Therapeutic hypothermia is cytoprotective without attenuating the traumatic brain injury-induced elevations in interstitial concentrations of aspartate and glutamate.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Injuries; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Histocytochemistry; Hypothermia, Induced; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence | 1993 |
Postnatal decrease of acetate concentration in rat cerebellum.
Topics: Acetates; Animals; Animals, Newborn; Aspartic Acid; Cerebellum; Glutamates; Glutamic Acid; Magnetic Resonance Spectroscopy; Rats; Rats, Wistar | 1994 |
New approaches to blood cardioplegic delivery to reduce hemodilution and cardioplegic overdose.
Topics: Animals; Aspartic Acid; Cardioplegic Solutions; Glutamates; Glutamic Acid; Heart Arrest, Induced; Hemodilution; Potassium; Swine; Swine, Miniature | 1994 |
Opioid receptor antagonist nalmefene stereospecifically inhibits glutamate release during global cerebral ischemia.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Hippocampus; Ischemic Attack, Transient; Kinetics; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Reperfusion; Stereoisomerism; Taurine; Time Factors | 1993 |
Heterocarrier-mediated reciprocal modulation of glutamate and glycine release in rat cerebral cortex and spinal cord synaptosomes.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium; Spinal Cord; Synaptosomes | 1994 |
Direct selection of binding proficient/catalytic deficient variants of BamHI endonuclease.
Topics: Aspartic Acid; Base Sequence; Binding Sites; Catalysis; Deoxyribonuclease BamHI; DNA; Drug Resistance; Glutamates; Glutamic Acid; Hydroxylamine; Hydroxylamines; Molecular Sequence Data; Mutagenesis; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; Repressor Proteins; Sequence Analysis; Spectinomycin | 1994 |
Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study.
Topics: Animals; Aspartic Acid; Drug Implants; Extracellular Space; Glutamates; Glutamic Acid; Locus Coeruleus; Male; Microdialysis; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1994 |
Identification of Glu340 as the active-site nucleophile in human glucocerebrosidase by use of electrospray tandem mass spectrometry.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Deoxyglucose; Glucosylceramidase; Glutamates; Glutamic Acid; Humans; Kinetics; Mass Spectrometry; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Recombinant Proteins | 1994 |
Catalysis by Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proposed roles of histidine 865, glutamate 558, and aspartate 766.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Catalysis; Cloning, Molecular; Cricetinae; Glutamates; Glutamic Acid; Histidine; Hydrogen-Ion Concentration; Hydroxymethylglutaryl CoA Reductases; Kinetics; Mesocricetus; Models, Theoretical; Mutagenesis, Site-Directed; Peptide Fragments; Point Mutation; Recombinant Proteins | 1994 |
An immunohistochemical study of aspartate, glutamate, and taurine in rat kidney.
Topics: Animals; Aspartic Acid; Female; Glutamates; Glutamic Acid; Immunoenzyme Techniques; Kidney; Male; Rats; Rats, Wistar; Taurine | 1994 |
Pharmacological characterization of a cloned rat glutamate transporter (GluT-1).
Topics: Amino Acid Transport System X-AG; Amino Acids; Animals; Aspartic Acid; Biological Transport; Cloning, Molecular; Female; Glutamates; Glutamic Acid; Glycoproteins; Kinetics; Oocytes; Rats; Xenopus | 1994 |
Effect of aspartate and glutamate on the oxoglutarate carrier investigated in rat heart mitochondria and inverted submitochondrial vesicles.
Topics: Animals; Aspartic Acid; Carrier Proteins; Glutamates; Glutamic Acid; Ketoglutaric Acids; Kinetics; Malates; Membrane Transport Proteins; Mitochondria, Heart; Rats | 1994 |
Effects of apomorphine and L-methionine sulphoximine on the release of excitatory amino acid neurotransmitters and glutamine in the striatum of the conscious rat.
Topics: Analysis of Variance; Animals; Apomorphine; Aspartic Acid; Corpus Striatum; Glutamates; Glutamic Acid; Glutamine; Haloperidol; Kinetics; Male; Methionine Sulfoximine; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1994 |
L-glutamate as a neurotransmitter at baroreceptor afferents: evidence from in vivo microdialysis.
Topics: Animals; Aspartic Acid; Baroreflex; Calcium; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Male; Microdialysis; Neurons, Afferent; Neurotransmitter Agents; Phenylephrine; Potassium; Pressoreceptors; Rats; Rats, Inbred WKY; Solitary Nucleus; Tissue Fixation | 1994 |
Individual ionization constants of all the carboxyl groups in ribonuclease HI from Escherichia coli determined by NMR.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Escherichia coli; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Magnetic Resonance Spectroscopy; Ribonuclease H | 1994 |
Interactions of gamma-L-glutamyltaurine with excitatory aminoacidergic neurotransmission.
Topics: Aging; Animals; Aspartic Acid; Brain; Calcium; Cells, Cultured; Cerebellum; Cerebral Cortex; Cyclic GMP; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Kainic Acid; Mice; Neurons; Potassium; Rats; Rats, Wistar; Receptors, Glutamate; Stereoisomerism; Synaptic Transmission; Synaptosomes; Taurine | 1994 |
The structural basis for the altered substrate specificity of the R292D active site mutant of aspartate aminotransferase from E. coli.
Topics: Arginine; Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Crystallization; Electrochemistry; Escherichia coli; Glutamates; Glutamic Acid; Hydrogen Bonding; Molecular Structure; Mutation; Protein Structure, Tertiary; Structure-Activity Relationship; Substrate Specificity | 1994 |
Cerebellar alpha-ketoglutarate dehydrogenase activity is reduced in spinocerebellar ataxia type 1.
Topics: Adult; Aspartic Acid; Cerebellum; Cerebral Cortex; Energy Metabolism; Glutamates; Glutamic Acid; Humans; Ketoglutarate Dehydrogenase Complex; Neurotransmitter Agents; Reference Values; Spinocerebellar Degenerations | 1994 |
The Na(+)-dependent binding of [3H]L-aspartate in thaw-mounted sections of rat forebrain.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Autoradiography; Dicarboxylic Acids; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Neurotransmitter Uptake Inhibitors; Presynaptic Terminals; Prosencephalon; Pyrrolidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Sodium | 1994 |
Attractant- and disulfide-induced conformational changes in the ligand binding domain of the chemotaxis aspartate receptor: a 19F NMR study.
Topics: Aspartic Acid; Binding Sites; Cell Membrane; Chemotactic Factors; Chemotaxis; Disulfides; Escherichia coli; Glutamates; Glutamic Acid; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; p-Fluorophenylalanine; Protein Conformation; Receptors, Amino Acid; Recombinant Proteins; Salmonella typhimurium | 1994 |
Conformational analysis of carboxylate and carboxamide side-chains bound to cations.
Topics: Amino Acid Sequence; Aspartic Acid; Crystallography, X-Ray; Glutamates; Glutamic Acid; Glutamine; Mathematics; Protein Conformation; Proteins | 1994 |
Release of glutamate and aspartate from the preoptic area during the progesterone-induced LH surge: in vivo microdialysis studies.
Topics: Animals; Aspartic Acid; Estradiol; Feedback; Female; Follicle Stimulating Hormone; Glutamates; Glutamic Acid; Luteinizing Hormone; Microdialysis; Ovariectomy; Preoptic Area; Progesterone; Rats; Rats, Sprague-Dawley; Serine | 1994 |
Liquid chromatographic determination of acidic beta-aspartyl and gamma-glutamyl peptides in extracts of rat brain.
Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Chemistry Techniques, Analytical; Chromatography, Liquid; Dipeptides; False Positive Reactions; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Male; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds | 1994 |
Identification of two aspartates and a glutamate essential for the activity of endo-beta-N-acetylglucosaminidase H from Streptomyces plicatus.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Binding Sites; DNA, Bacterial; Glutamates; Glutamic Acid; Hexosaminidases; Hydrogen-Ion Concentration; Kinetics; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Plasmids; Recombinant Proteins; Restriction Mapping; Streptomyces | 1994 |
Characterization of antimycin resistant mutants of Rhodospirillum rubrum.
Topics: Amino Acid Sequence; Antimycin A; Aspartic Acid; Cytochrome b Group; Drug Resistance, Microbial; Electron Transport Complex III; Genes, Fungal; Glutamates; Glutamic Acid; Histidine; Point Mutation; Rhodospirillum rubrum | 1994 |
Effect of kynurenic acid on the ischaemia-induced accumulation of glutamate in rat striatum.
Topics: Animals; Aspartic Acid; Corpus Striatum; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ischemic Attack, Transient; Kynurenic Acid; Male; Microdialysis; Neurotransmitter Agents; Perfusion; Prosencephalon; Rats; Rats, Wistar | 1994 |
D-aspartate and D-glutamate in microwaved versus conventionally heated milk.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Hot Temperature; Microwaves; Milk | 1994 |
Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells.
Topics: Animals; Aspartic Acid; Cerebellar Cortex; Dendrites; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; In Vitro Techniques; Interneurons; Male; Mathematics; Models, Neurological; Nerve Fibers; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Synapses; Synaptic Transmission | 1994 |
Naloxone-precipitated morphine withdrawal increases pontine glutamate levels in the rat.
Topics: Animals; Aspartic Acid; Dialysis; Drug Interactions; Glutamates; Glutamic Acid; Locus Coeruleus; Male; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1994 |
Identification of residues in the Mu transposase essential for catalysis.
Topics: Amino Acid Sequence; Aspartic Acid; Bacteriophage mu; Binding Sites; Catalysis; Conserved Sequence; DNA Nucleotidyltransferases; DNA-Binding Proteins; Glutamates; Glutamic Acid; Integrases; Macromolecular Substances; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleotidyltransferases; Point Mutation; Recombinant Proteins; Sequence Homology, Amino Acid; Transposases | 1994 |
Three new mutations of thyroid hormone receptor-beta associated with resistance to thyroid hormone.
Topics: Adolescent; Adult; Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Drug Resistance; Female; Glutamates; Glutamic Acid; Glutamine; Humans; Lysine; Male; Molecular Sequence Data; Point Mutation; Receptors, Thyroid Hormone; Sicily; Syndrome; Thyroid Hormones | 1994 |
Separation and quantitation of the amino acid neurotransmitters in rat brain by capillary electrophoresis.
Topics: Animals; Aspartic Acid; Brain Chemistry; Dopamine; Electrophoresis; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Neurotransmitter Agents; Norepinephrine; Rats | 1994 |
The effect of L-glutamate on the afferent resting activity in the cephalopod statocyst.
Topics: Action Potentials; Afferent Pathways; Animals; Aspartic Acid; Decapodiformes; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Mollusca; N-Methylaspartate; Nerve Fibers; Octopodiformes; Postural Balance; Quisqualic Acid; Species Specificity | 1994 |
High affinity uptake of glutamate and aspartate in the developing rat retina.
Topics: Aging; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Kinetics; Rats; Retina; Subcellular Fractions; Synaptosomes | 1994 |
Enhanced aspartate release related to epilepsy in (EL) mice.
Topics: Aging; Animals; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Potassium; Seizures; Species Specificity | 1994 |
Physiological elevations of glucocorticoids potentiate glutamate accumulation in the hippocampus.
Topics: Adrenalectomy; Animals; Aspartic Acid; Corticosterone; Delayed-Action Preparations; Glutamates; Glutamic Acid; Glutamine; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Taurine | 1994 |
Effects of ischaemic conditions on uptake of glutamate, aspartate, and noradrenaline by cell lines derived from the human nervous system.
Topics: Aspartic Acid; Astrocytoma; Biological Transport; Cell Hypoxia; Cell Line; Glutamates; Glutamic Acid; Humans; Hypoglycemia; Ischemia; Kinetics; Models, Neurological; Neuroblastoma; Norepinephrine; Tritium; Tumor Cells, Cultured | 1994 |
Evidence supporting catalytic roles for aspartate residues in phosphoribulokinase.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Binding Sites; DNA Primers; Genes, Bacterial; Glutamates; Glutamic Acid; Kinetics; Molecular Sequence Data; Mutagenesis, Insertional; Mutagenesis, Site-Directed; Phosphotransferases (Alcohol Group Acceptor); Recombinant Proteins; Restriction Mapping; Rhodobacter sphaeroides; Sequence Homology, Amino Acid | 1994 |
Subcellular fractionation on Percoll gradient of mossy fiber synaptosomes: evoked release of glutamate, GABA, aspartate and glutamate decarboxylase activity in control and degranulated rat hippocampus.
Topics: Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Centrifugation, Density Gradient; Chromatography, High Pressure Liquid; Cytoplasmic Granules; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Hippocampus; Male; Nerve Fibers; Presynaptic Terminals; Rats; Rats, Wistar; Subcellular Fractions; Synaptosomes | 1994 |
[Nootropic drugs potentiate nerve cell responses evoked by NMDA-glutamate receptor activation].
Topics: Amnesia; Animals; Aspartic Acid; Electroshock; Glutamates; Glutamic Acid; Membrane Potentials; Motor Neurons; Neurotransmitter Agents; Psychotropic Drugs; Ranidae; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1993 |
Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria.
Topics: Animals; Aspartic Acid; Calcium; Dinitrophenols; Enzyme Activation; Glutamates; Glutamic Acid; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Malates; Membrane Potentials; Mitochondria, Heart; Models, Biological; NAD; Pyruvates; Pyruvic Acid; Rats | 1994 |
High-resolution 1H-magnetic resonance spectroscopy of pediatric posterior fossa tumors in vitro.
Topics: Adolescent; Alanine; Amino Acids; Animals; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Choline; Cranial Fossa, Posterior; Glutamates; Glutamic Acid; Humans; In Vitro Techniques; Infant; Magnetic Resonance Spectroscopy; Medulloblastoma; Neuroectodermal Tumors; Neurotransmitter Agents; Rats; Valine | 1994 |
Double-echo multislice proton spectroscopic imaging using Hadamard slice encoding.
Topics: Animals; Aspartic Acid; Brain; Choline; Creatine; Fourier Analysis; Glutamates; Glutamic Acid; Glutamine; Image Enhancement; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Models, Structural; Phosphocreatine; Protons; Rats; Rats, Wistar; Water | 1994 |
Measurement of GABA following GABA-transaminase inhibition by gabaculine: a 1H and 31P NMR spectroscopic study of rat brain in vivo.
Topics: 4-Aminobutyrate Transaminase; Animals; Aspartic Acid; Brain; Brain Chemistry; Creatine; Cyclohexanecarboxylic Acids; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hydrogen; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Nucleotides; Phosphates; Phosphocreatine; Phosphorus; Rats; Rats, Sprague-Dawley | 1994 |
Dietary pectin's effect on ileal and fecal amino acid digestibility and exocrine pancreatic secretions in growing pigs.
Topics: alpha-Amylases; Amino Acids; Animals; Aspartic Acid; Dietary Fiber; Digestion; Feces; Glutamates; Glutamic Acid; Glycine; Ileum; Male; Pancreas; Pancreatic Juice; Pectins; Phenylalanine; Proline; Serine; Swine; Threonine; Trypsin; Valine | 1994 |
Presence of X-AG carrier in frog (Rana esculenta) red blood cells.
Topics: Amino Acid Transport System X-AG; Amino Acid Transport Systems; Amino Acids; Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Erythrocytes; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycoproteins; Rana esculenta | 1994 |
Aspartate aminotransferase and glutaminase activities in rat olfactory bulb and cochlear nucleus; comparisons with retina and with concentrations of substrate and product amino acids.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Aspartic Acid; Cochlear Nucleus; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Isoenzymes; Malate Dehydrogenase; Olfactory Bulb; Organ Specificity; Rats; Rats, Sprague-Dawley; Retina | 1994 |
Dextrorphan inhibits the release of excitatory amino acids during spinal cord ischemia.
Topics: Amino Acids; Animals; Aspartic Acid; Dextrorphan; Evoked Potentials; Evoked Potentials, Somatosensory; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ischemia; Microdialysis; Motor Cortex; Neurotransmitter Agents; Receptors, Amino Acid; Serine; Spinal Cord; Swine | 1994 |
Specific [3H]L-glutamate binding and [3H]D-aspartate release in the hippocampus of rat after pentylenetetrazol kindling and long-term potentiation.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hippocampus; Kindling, Neurologic; Kinetics; Long-Term Potentiation; Male; Pentylenetetrazole; Rats; Rats, Wistar; Reference Values; Time Factors; Tritium | 1994 |
Isolation and properties of mitochondrial aspartate aminotransferase from red muscle of grey mullet, Mugil auratus Risso.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Catalysis; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Glutamates; Glutamic Acid; Hydroxylamine; Hydroxylamines; Isoelectric Focusing; Isoelectric Point; Ketoglutaric Acids; Kinetics; Mitochondria, Muscle; Molecular Weight; Muscles; Oxaloacetates; Perciformes | 1994 |
Properties of the flavoenzyme D-aspartate oxidase from Octopus vulgaris.
Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Cattle; Chemical Phenomena; Chemistry, Physical; D-Aspartate Oxidase; Flavin-Adenine Dinucleotide; Glutamates; Glutamic Acid; Kidney; Kinetics; Molecular Sequence Data; Octopodiformes; Spectrophotometry; Substrate Specificity; Swine | 1994 |
Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cell Membrane; Cells, Cultured; Electrochemistry; Glutamates; Glutamic Acid; Magnesium; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Potassium Channels; Potassium Channels, Inwardly Rectifying; Recombinant Proteins; Xenopus | 1994 |
Characterization of glutamate, aspartate, and GABA release from ischemic rat cerebral cortex.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Brain Ischemia; Cerebral Cortex; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycoproteins; L-Lactate Dehydrogenase; Male; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 1994 |
Identification of the major brown shrimp (Penaeus aztecus) allergen as the muscle protein tropomyosin.
Topics: Allergens; Amino Acid Sequence; Animals; Arthropod Proteins; Aspartic Acid; Food Hypersensitivity; Glutamates; Glutamic Acid; Humans; Molecular Sequence Data; Penaeidae; Proteins; Radioallergosorbent Test; Sequence Homology, Amino Acid; Tropomyosin | 1994 |
A calbindin D9k mutant with reduced calcium affinity and enhanced cooperativity. Metal ion binding, stability, and structural studies.
Topics: Aspartic Acid; Binding Sites; Cadmium; Calbindins; Calcium; Calorimetry, Differential Scanning; Crystallography, X-Ray; Drug Stability; Glutamic Acid; Hot Temperature; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Structure; Mutation; S100 Calcium Binding Protein G; Structure-Activity Relationship; Thermodynamics | 1994 |
Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Extracellular Space; Glutamic Acid; In Vitro Techniques; Ischemic Attack, Transient; Male; Microdialysis; Neostriatum; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1994 |
Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutamate and aspartate in the mouse brain.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Aspartic Acid; Brain Chemistry; Deoxyglucose; Energy Metabolism; Glutamic Acid; Male; Mazindol; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate; Selegiline | 1994 |
Glutamic acid 86 is important for positioning the 80's loop and arginine 54 at the active site of Escherichia coli aspartate transcarbamoylase and for the structural stabilization of the C1-C2 interface.
Topics: Aspartate Carbamoyltransferase; Aspartic Acid; Binding Sites; Enzyme Stability; Escherichia coli; Glutamic Acid; Kinetics; Mutagenesis, Site-Directed; Phosphonoacetic Acid; Structure-Activity Relationship | 1994 |
The effects of L-glutamate and trans-(+-)-1-amino-1,3-cyclopentanedicarboxylate on phosphoinositide hydrolysis can be pharmacologically differentiated.
Topics: Alanine; Animals; Animals, Newborn; Aspartic Acid; Benzoates; Brain; Cerebellum; Cycloleucine; Glutamic Acid; Glycine; Hippocampus; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kinetics; Neurotoxins; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Stereoisomerism | 1994 |
Metabolic abnormalities and grade of encephalopathy in acute hepatic failure.
Topics: Ammonia; Animals; Arginine; Aspartic Acid; Blood Glucose; Blood-Brain Barrier; Brain Chemistry; Brain Diseases, Metabolic; Glutamic Acid; Lactates; Liver Failure, Acute; Male; Pyruvates; Rats | 1994 |
Protection by alcuronium of muscarinic receptors against chemical inactivation and location of the allosteric binding site for alcuronium.
Topics: Acetylcholine; Alcuronium; Allosteric Site; Animals; Aspartic Acid; Atropine; Carbachol; Choline; Cholinergic Agents; Female; Gallamine Triethiodide; Glutamic Acid; Heart Atria; Male; Parasympatholytics; Rats; Rats, Wistar; Receptors, Muscarinic; Tyrosine | 1994 |
Effects of cholecystokinin octapeptide and BC 264, a potent and selective CCK-B agonist on aspartate and glutamate release from rat hippocampal slices.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Benzodiazepinones; Calcium; Cholecystokinin; Glutamic Acid; Hippocampus; In Vitro Techniques; Interneurons; Male; Molecular Sequence Data; Peptide Fragments; Phenylurea Compounds; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Sincalide | 1994 |
Effects of the intracerebroventricular administration of ketamine on centrogenic arrhythmias in anesthetized rats.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Aspartic Acid; Cerebral Ventricles; Desipramine; Electrocardiography; European Union; Female; Glutamic Acid; Injections, Intraventricular; Ketamine; Male; Ouabain; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, N-Methyl-D-Aspartate | 1994 |
Evoked neuronal secretion of false transmitters.
Topics: Acetylcholine; Animals; Aspartic Acid; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Evoked Potentials; Glutamic Acid; Guinea Pigs; Hippocampus; Kinetics; Neurons; Neurotransmitter Agents; Spinal Cord; Xenopus | 1994 |
Contribution of residues in the reactive site loop of chymotrypsin inhibitor 2 to protein stability and activity.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Chymotrypsin; Glutamic Acid; Kinetics; Molecular Sequence Data; Mutation; Peptides; Plant Proteins; Protein Denaturation; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Solanum tuberosum; Subtilisins; Thermodynamics; Threonine | 1994 |
Reaction energetics of a mutant 3-oxo-delta 5-steroid isomerase with an altered active site base (D38E).
Topics: Aspartic Acid; Binding Sites; Catalysis; Glutamic Acid; Kinetics; Methanol; Mutation; Steroid Isomerases; Thermodynamics | 1994 |
Determination of aspartate aminotransferase activity by high-performance liquid chromatography.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Buffers; Cattle; Chromatography, High Pressure Liquid; Glutamic Acid; Hydrogen-Ion Concentration; Indicators and Reagents; Phosphates; Spectrophotometry, Ultraviolet | 1994 |
Indomethacin modulates ischemia-evoked release of glutamate and adenosine from the rat cerebral cortex.
Topics: Adenosine; Animals; Aspartic Acid; Blood Pressure; Brain Ischemia; Cell Death; Cerebral Cortex; Electroencephalography; gamma-Aminobutyric Acid; Glutamic Acid; Indomethacin; Rats; Rats, Sprague-Dawley; Reperfusion | 1994 |
A subtype of the metabotropic glutamate receptor family in the olfactory system of Atlantic salmon.
Topics: Animals; Aspartic Acid; Blotting, Northern; Brain; Cell Membrane; DNA Probes; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kainic Acid; N-Methylaspartate; Nucleic Acid Hybridization; Olfactory Mucosa; Rats; Receptors, Metabotropic Glutamate; Salmon; Taurocholic Acid; Type C Phospholipases | 1994 |
Identification of two active site residues in human angiotensin I-converting enzyme.
Topics: Amino Acid Sequence; Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartic Acid; Binding Sites; Cells, Cultured; DNA, Complementary; Glutamic Acid; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptidyl-Dipeptidase A; Sequence Alignment | 1994 |
Bacterial multidrug resistance is due to a single membrane protein which functions as a drug pump.
Topics: Amino Acid Sequence; Antiporters; Aspartic Acid; Bacterial Proteins; Base Sequence; Carrier Proteins; DNA Mutational Analysis; DNA Primers; Drug Resistance, Microbial; Drug Resistance, Multiple; Escherichia coli Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Membrane Proteins; Molecular Sequence Data; Phenotype; Proteolipids; Staphylococcus; Tryptophan | 1994 |
L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a.
Topics: Alanine Transaminase; Animals; Asparagine; Aspartic Acid; Cell Line; Cell Membrane; Cricetinae; Cycloleucine; Cysteine; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamate Decarboxylase; Glutamic Acid; Hydrolysis; Kidney; N-Methylaspartate; Phosphatidylinositols; Pyrrolidines; Receptors, Metabotropic Glutamate | 1994 |
Effect of isonicotinic acid hydrazide on extracellular amino acids and convulsions in the rat: reversal of neurochemical and behavioural deficits by sodium valproate.
Topics: Amino Acids; Animals; Aspartic Acid; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Isoniazid; Kinetics; Male; Potassium; Rats; Rats, Wistar; Seizures; Taurine; Valproic Acid | 1994 |
Inflammation-induced release of excitatory amino acids is prevented by spinal administration of a GABAA but not by a GABAB receptor antagonist in rats.
Topics: Animals; Arthritis; Aspartic Acid; Bicuculline; Excitatory Amino Acids; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Glutamic Acid; Hyperalgesia; Organophosphorus Compounds; Rats; Receptors, GABA-A; Receptors, GABA-B; Spinal Cord | 1994 |
A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Base Sequence; Binding Sites; Cell Membrane; Conserved Sequence; Glutamic Acid; Ion Channel Gating; Leukemia, Erythroblastic, Acute; Magnesium; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Structure, Secondary; Transfection; Tumor Cells, Cultured | 1994 |
Endogenous gamma-L-glutamyl and beta-L-aspartyl peptides and excitatory aminoacidergic neurotransmission in the brain.
Topics: Animals; Aspartic Acid; Brain; Cell Membrane; Excitatory Amino Acids; Glutamic Acid; In Vitro Techniques; Neurotransmitter Agents; Oligopeptides; Rats; Rats, Wistar; Synaptic Transmission; Synaptosomes | 1994 |
Long-term effects of perinatal asphyxia on basal ganglia neurotransmitter systems studied with microdialysis in rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Asphyxia Neonatorum; Basal Ganglia; Cesarean Section; Corpus Striatum; Dopamine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Homovanillic Acid; Humans; Infant, Newborn; Male; Microdialysis; Neurotransmitter Agents; Pregnancy; Rats; Rats, Sprague-Dawley; Reference Values; Substantia Nigra | 1994 |
Effects of introduced aspartic and glutamic acid residues on the P'1 substrate specificity, pH dependence and stability of carboxypeptidase Y.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Binding Sites; Carboxypeptidases; Cathepsin A; Fungal Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Protein Denaturation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Structure-Activity Relationship; Substrate Specificity | 1994 |
Neuroprotective effects of tetrodotoxin as a Na+ channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Calcium; Calcium-Transporting ATPases; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gerbillinae; Glutamic Acid; Hippocampus; Ion Transport; Neurons; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Reperfusion; Sodium Channel Blockers; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Tetrodotoxin; Veratridine | 1994 |
Proton MR spectroscopy of experimental brain tumors in vivo.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Edema; Brain Neoplasms; Caudate Nucleus; Cell Line; Choline; Creatinine; Energy Metabolism; Glioma; Glutamic Acid; Inositol; Magnetic Resonance Imaging; Male; Neoplasm Transplantation; Neurilemmoma; Neuroblastoma; Phosphocreatine; Rats; Rats, Inbred F344 | 1994 |
An assessment of progression of brain edema with amino acid levels in cerebrospinal fluid and changes in electroencephalogram in an adult cat model of cold brain injury.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cats; Electroencephalography; Evoked Potentials; Freezing; Glutamic Acid; Methionine; Motor Cortex; Phenylalanine; Serine; Synaptic Transmission; Tyrosine; Valine | 1994 |
Variations in the amino acid composition of cyanophycin in the cyanobacterium Synechocystis sp. PCC 6308 as a function of growth conditions.
Topics: Amino Acids; Arginine; Aspartic Acid; Bacterial Proteins; Cyanobacteria; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Nitrogen Isotopes; Plant Proteins | 1994 |
Regional differences in the inhibition of L-glutamate and L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylate, threo-3-hydroxy-D-aspartate and D-aspartate.
Topics: Analysis of Variance; Animals; Aspartic Acid; Biological Transport; Cerebellum; Dicarboxylic Acids; Glutamic Acid; Hippocampus; Male; Organ Specificity; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium; Spinal Cord; Stereoisomerism | 1994 |
The immunocytochemical localization of glutamate in the electrosensory system of the gymnotiform fish, Apteronotus leptorhynchus.
Topics: Animals; Aspartic Acid; Electric Fish; Electric Organ; Fluorescent Antibody Technique; Glutamic Acid; Immunohistochemistry; Microscopy, Electron; Tissue Distribution | 1994 |
Anionic amino acid transport in ras- transformed fibroblasts.
Topics: Amino Acids; Anions; Aspartic Acid; Cell Line, Transformed; Cells, Cultured; Culture Media; Dexamethasone; Fibroblasts; Gene Expression; Genes, ras; Glutamic Acid; Lovastatin | 1993 |
N-methyl-D-aspartate releases gamma-aminobutyric acid from rat striatum in vivo: a microdialysis study using a novel preloading method.
Topics: Animals; Aspartic Acid; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Infusions, Parenteral; Kinetics; Male; N-Methylaspartate; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Tritium | 1993 |
Presynaptic alpha 2 adrenoceptors inhibit glutamate release from rat spinal cord synaptosomes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Calcium; Chromatography, High Pressure Liquid; Clonidine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Isoproterenol; Kinetics; Male; Norepinephrine; Phenylephrine; Potassium Chloride; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Spinal Cord; Synaptosomes | 1993 |
Distinct actions of endogenous excitatory amino acids on the outflow of dopamine in the nucleus accumbens.
Topics: Amino Acids; Animals; Aspartic Acid; Dialysis; Dopamine; Glutamates; Glutamic Acid; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Tetrodotoxin | 1993 |
The conservative substitution Asp-645-->Glu in lysosomal alpha-glucosidase affects transport and phosphorylation of the enzyme in an adult patient with glycogen-storage disease type II.
Topics: Adult; Alleles; alpha-Glucosidases; Aspartic Acid; Base Sequence; beta-N-Acetylhexosaminidases; Biological Transport; Black People; Cells, Cultured; Codon; DNA Mutational Analysis; Glutamates; Glutamic Acid; Glycogen; Glycogen Storage Disease Type II; Humans; Lysosomes; Microscopy, Immunoelectron; Molecular Sequence Data; Phenotype; Phosphorylation; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Protein Processing, Post-Translational; Regulatory Sequences, Nucleic Acid; Sequence Analysis, DNA; Tunicamycin | 1993 |
Subcortical excitatory amino acid levels after acute and subchronic administration of typical and atypical neuroleptics.
Topics: Animals; Antipsychotic Agents; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Drug Administration Schedule; Glutamates; Glutamic Acid; Injections, Subcutaneous; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1993 |
Cardiopulmonary dysfunction produced by reoxygenation of immature hypoxemic animals supported by cardiopulmonary bypass. Prevention by intravenous metabolic pretreatment.
Topics: Animals; Aspartic Acid; Cardiopulmonary Bypass; Catalase; Drug Combinations; Glucose; Glutamates; Glutamic Acid; Heart; Hemodynamics; Hypoxia; Infusions, Intravenous; Insulin; Lung; Oxygen; Pressure; Swine; Vascular Resistance | 1993 |
Autoradiography of L-[3H]aspartate binding sites.
Topics: Amino Acid Transport Systems; Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Buffers; Carrier Proteins; Cysteic Acid; Cysteine; Glutamates; Glutamic Acid; Kinetics; Male; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Sodium; Stereoisomerism; Tritium | 1993 |
Methylmercury-induced alterations in excitatory amino acid transport in rat primary astrocyte cultures.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Cells, Cultured; Fluorenes; Furosemide; Glutamates; Glutamic Acid; Methylmercury Compounds; Rats; Rats, Sprague-Dawley; Sodium | 1993 |
In situ changes in purine nucleotide and N-acetyl concentrations upon inducing global ischemia in cat brain.
Topics: Acetylation; Adenosine; Animals; Aspartic Acid; Brain Ischemia; Cats; Choline; Creatine; Female; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Glycine; Magnetic Resonance Spectroscopy; Male; Purine Nucleotides; Taurine | 1993 |
An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Male; Microinjections; Nerve Degeneration; Niacin; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Serine; Threonine | 1993 |
1H magnetic resonance spectroscopy of extracts of human epileptic neocortex and hippocampus.
Topics: Adolescent; Adult; Amino Acids; Aspartic Acid; Cerebral Cortex; Child; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged | 1993 |
1H nuclear magnetic resonance spectroscopy study of cerebral glutamate in an ex vivo brain preparation of guinea pig.
Topics: Animals; Aspartic Acid; Brain; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Energy Metabolism; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Nigericin; Oxygen; Sodium Cyanide | 1993 |
Release of endogenous glutamic and aspartic acids from cerebrocortex synaptosomes and its modulation through activation of a gamma-aminobutyric acidB (GABAB) receptor subtype.
Topics: Animals; Aspartic Acid; Baclofen; Bicuculline; Cerebral Cortex; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kinetics; Male; Organophosphorus Compounds; Picrotoxin; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptosomes | 1993 |
Structural and functional organization of the surfactin synthetase multienzyme system.
Topics: Aspartic Acid; Bacillus subtilis; Bacterial Proteins; Centrifugation, Density Gradient; Chromatography, Gel; Chromatography, Ion Exchange; Glutamates; Glutamic Acid; Kinetics; Leucine; Macromolecular Substances; Multienzyme Complexes; Peptide Synthases; Substrate Specificity; Valine | 1993 |
Role of Asp51 and Glu105 in the enzymatic activity of a ribonuclease from Rhizopus niveus.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Binding Sites; Catalysis; Glutamates; Glutamic Acid; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Rhizopus; Ribonucleases; Sequence Homology, Amino Acid | 1993 |
An experimental arthritis model in rats: the effects of NMDA and non-NMDA antagonists on aspartate and glutamate release in the dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Arthritis; Aspartic Acid; Carrageenan; Glutamates; Glutamic Acid; Injections, Intra-Articular; Kaolin; Knee Joint; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Spinal Cord | 1993 |
Stress preferentially increases extraneuronal levels of excitatory amino acids in the prefrontal cortex: comparison to hippocampus and basal ganglia.
Topics: Animals; Aspartic Acid; Basal Ganglia; Extracellular Space; Frontal Lobe; Glutamates; Glutamic Acid; Hippocampus; Rats; Restraint, Physical; Stress, Physiological; Swimming | 1993 |
Cerebral aspartate utilization: near-equilibrium relationships in aspartate aminotransferase reaction.
Topics: Adenine Nucleotides; Animals; Aspartate Aminotransferases; Aspartic Acid; Astrocytes; Brain; Cells, Cultured; Glutamates; Glutamic Acid; Male; Rats; Rats, Sprague-Dawley; Rotenone; Synaptosomes | 1993 |
Evidence using in vivo microdialysis that aminotransferase activities are important in the regulation of the pools of transmitter amino acids.
Topics: Alanine; Amino Acids; Aminooxyacetic Acid; Animals; Aspartic Acid; Dialysis; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Male; Neostriatum; Neurotransmitter Agents; Potassium; Rats; Rats, Wistar; Transaminases | 1993 |
Contribution of organic and inorganic osmolytes to volume regulation in rat brain cells in culture.
Topics: Amino Acids; Animals; Aspartic Acid; Astrocytes; beta-Alanine; Brain; Cells, Cultured; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kinetics; Neurons; Osmolar Concentration; Potassium; Rats; Rubidium; Taurine | 1993 |
Osmotic adaptation of renal medullary cells during transition from chronic diuresis to antidiuresis.
Topics: Alanine; Animals; Aspartic Acid; Chlorides; Chromatography, High Pressure Liquid; Cryoultramicrotomy; Deamino Arginine Vasopressin; Diuresis; Electron Probe Microanalysis; Furosemide; Glutamates; Glutamic Acid; Glycine; Kidney Medulla; Male; Methylamines; Osmosis; Polymers; Potassium; Rats; Rats, Wistar; Sodium; Taurine; Urea | 1993 |
Amino acids modify activity of canine intrinsic cardiac neurons involved in cardiac regulation.
Topics: Amino Acids; Animals; Aspartic Acid; Atropine; Dogs; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Heart; Hexamethonium; Hexamethonium Compounds; Male; Microinjections; Neurons; Parasympathetic Nervous System; Sympathetic Nervous System; Timolol | 1993 |
Effect of anoxia on excitatory amino acids in brain slices of rats and turtles: in vitro microdialysis.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Stem; Dialysis; Glutamates; Glutamic Acid; Glutamine; Glycine; Hypoxia; Rats; Rats, Sprague-Dawley; Time Factors; Turtles | 1993 |
Changes in the brain levels of GABA and related amino acids in anoxic shore crab (Carcinus maenas).
Topics: Alanine; Amino Acids, Branched-Chain; Animals; Aspartic Acid; Brachyura; Brain Chemistry; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hypoxia; Taurine | 1993 |
Variant of canine erythrocytes with high potassium content and lack of glutathione accumulation.
Topics: Animals; Aspartic Acid; Dogs; Erythrocyte Count; Erythrocytes; Glutamates; Glutamic Acid; Glutamine; Glutathione; Hematocrit; Hemoglobins; Potassium; Rubidium; Sodium-Potassium-Exchanging ATPase | 1993 |
Uptake, release and metabolism of glutamate and aspartate by rat cerebellar subcellular preparations.
Topics: 4-Aminobutyrate Transaminase; Analysis of Variance; Animals; Aspartic Acid; Cerebellum; Cytosol; Glutamate Decarboxylase; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Kinetics; Male; Mitochondria; Oxidation-Reduction; Rats; Rats, Wistar; Subcellular Fractions; Synaptosomes | 1993 |
Neuroexcitatory amino acid levels in plasma and cerebrospinal fluid during migraine attacks.
Topics: Adult; Aspartic Acid; Female; Glutamates; Glutamic Acid; Humans; Male; Migraine Disorders; Nervous System Diseases; Reference Values | 1993 |
Glutamate and taurine uptake by retinal pigment epithelium during rat development.
Topics: Animals; Aspartic Acid; Biological Transport; Glutamates; Glutamic Acid; In Vitro Techniques; Pigment Epithelium of Eye; Rats; Taurine | 1993 |
Determination of the pKa values of active-center cysteines, cysteines-32 and -35, in Escherichia coli thioredoxin by Raman spectroscopy.
Topics: Amino Acid Sequence; Aspartic Acid; Chemical Phenomena; Chemistry, Physical; Cysteine; Escherichia coli; Glutamates; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Molecular Sequence Data; Protein Conformation; Protein Structure, Secondary; Solutions; Spectrum Analysis, Raman; Thioredoxins; Tryptophan; Tyrosine | 1993 |
Predicting the topology of eukaryotic membrane proteins.
Topics: Aspartic Acid; Glutamates; Glutamic Acid; Membrane Proteins; Tryptophan; Tyrosine | 1993 |
Nitric oxide increases interstitial excitatory amino acid release in the rat dorsomedial medulla oblongata.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Stem; Cerebellum; Dialysis; Extracellular Space; Glutamates; Glutamic Acid; Injections, Intraventricular; Male; Medulla Oblongata; Methylene Blue; Nitric Oxide; Penicillamine; Rats; Rats, Inbred WKY; S-Nitroso-N-Acetylpenicillamine | 1993 |
Uptake and metabolism of glutamate and aspartate by astroglial and neuronal preparations of rat cerebellum.
Topics: Animals; Aspartic Acid; Astrocytes; Carbon Dioxide; Cerebellar Cortex; Cerebellum; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Neurons; Rats; Rats, Wistar; Synaptosomes | 1993 |
Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats.
Topics: Animals; Aspartic Acid; Clozapine; Corpus Striatum; Frontal Lobe; Glutamates; Glutamic Acid; Haloperidol; Male; Rats; Rats, Sprague-Dawley | 1993 |
Identification of N,N'-dicyclohexylcarbodiimide-reactive glutamic and aspartic acid residues in Escherichia coli transhydrogenase and the exchange of these by site-specific mutagenesis.
Topics: Amino Acid Sequence; Aspartic Acid; Cell Membrane; Cloning, Molecular; Dicyclohexylcarbodiimide; Escherichia coli; Glutamates; Glutamic Acid; Kinetics; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP Transhydrogenases; Recombinant Proteins | 1993 |
Selection of Chinese hamster ovary cells (CHO-K1) with reduced glutamate and aspartate uptake.
Topics: Animals; Aspartic Acid; Biological Transport; Cell Death; Cell Separation; CHO Cells; Cricetinae; Glutamates; Glutamic Acid; Kinetics; Mutation | 1993 |
Multiple subtypes of excitatory amino acid receptors coupled to the hydrolysis of phosphoinositides in rat brain.
Topics: Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Cycloleucine; Glutamates; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, Glutamate | 1993 |
"In vivo" glutamic acid metabolism in late pregnant rats.
Topics: Animals; Aspartic Acid; Blood Glucose; Blood Proteins; Female; Gluconeogenesis; Glucose; Glutamates; Glutamic Acid; Glutamine; Liver; Muscles; Pregnancy; Pregnancy, Animal; Proteins; Rats; Rats, Wistar; Starvation | 1993 |
Plasma concentrations of glutamate and its metabolites in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminobutyrates; Aspartic Acid; Discriminant Analysis; Female; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Humans; Ketoglutaric Acids; Male; Mass Screening; Middle Aged; Pilot Projects; Sensitivity and Specificity | 1993 |
Effects of amino acids on substrate selection, anaplerosis, and left ventricular function in the ischemic reperfused rat heart.
Topics: Acetyl Coenzyme A; Alanine; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Heart; In Vitro Techniques; Lactates; Magnetic Resonance Spectroscopy; Male; Myocardial Reperfusion; Myocardium; Rats; Rats, Sprague-Dawley | 1993 |
Adenosine influences the high-affinity uptake of transmitter glutamate and aspartate under conditions of hepatic encephalopathy.
Topics: Adenosine; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hepatic Encephalopathy; Humans; In Vitro Techniques; Male; Rats; Rats, Wistar | 1993 |
Binding of ferredoxin to ferredoxin:NADP+ oxidoreductase: the role of carboxyl groups, electrostatic surface potential, and molecular dipole moment.
Topics: Amino Acid Sequence; Amino Acids; Aspartic Acid; Binding Sites; Carbodiimides; Ferredoxin-NADP Reductase; Ferredoxins; Glutamates; Glutamic Acid; Mathematical Computing; Models, Molecular; Molecular Sequence Data; Plants; Taurine | 1993 |
Identification of glutamic acid 204 and aspartic acid 200 in chitinase A1 of Bacillus circulans WL-12 as essential residues for chitinase activity.
Topics: Amino Acid Sequence; Aspartic Acid; Bacillus; Base Sequence; Binding Sites; Catalysis; Chitin; Chitinases; Chitosan; Escherichia coli; Glutamates; Glutamic Acid; Hydrolysis; Kinetics; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Plasmids; Structure-Activity Relationship; Substrate Specificity | 1993 |
Cross-links in cell walls of Bacillus subtilis by rotational-echo double-resonance 15N NMR.
Topics: Aspartic Acid; Bacillus subtilis; Cell Wall; Cephalosporins; Glutamates; Glutamic Acid; Magnetic Resonance Spectroscopy; Nitrogen; Nitrogen Isotopes; Peptidoglycan | 1993 |
Clarification of the pH-dependent kinetic behaviour of papain by using reactivity probes and analysis of alkylation and catalysed acylation reactions in terms of multihydronic state models: implications for electrostatics calculations and interpretation o
Topics: Acylation; Alkylation; Asparagine; Aspartic Acid; Catalysis; Electrochemistry; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mutagenesis, Site-Directed; Papain; Substrate Specificity | 1993 |
Effect of unilateral motor cortex ablation on activity of choline acetyltransferase and levels of amino acid transmitter candidates in the spinal cord of adult monkeys.
Topics: Amino Acids; Animals; Aspartic Acid; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Macaca fascicularis; Motor Cortex; Neurotransmitter Agents; Spinal Cord; Taurine | 1993 |
Transmitter amino acid levels in rat brain regions after amygdala-kindling or chronic electrode implantation without kindling: evidence for a pro-kindling effect of prolonged electrode implantation.
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Brain; Chromatography, High Pressure Liquid; Electric Stimulation; Electrodes; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Kindling, Neurologic; Neurotransmitter Agents; Prostheses and Implants; Rats; Rats, Wistar; Seizures; Taurine | 1993 |
Effects of gradual reperfusion on postischemic metabolism and functional recovery of isolated guinea pig heart.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Amino Acids; Animals; Aspartic Acid; Cardiac Output; Energy Metabolism; Glutamates; Glutamic Acid; Guinea Pigs; Heart; In Vitro Techniques; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Nitrogen; Phosphocreatine | 1993 |
Citrate modulation of high-affinity aspartate transport in prostate epithelial cells.
Topics: Animals; Aspartic Acid; Biological Transport; Citrates; Epithelium; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Prostate; Rats; Rats, Wistar | 1993 |
Lysine 319 interacts with both glutamic acid 269 and aspartic acid 240 in the lactose carrier of Escherichia coli.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Cell Membrane; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Genotype; Glutamates; Glutamic Acid; Kinetics; Lactose; Lysine; Melibiose; Membrane Transport Proteins; Models, Structural; Molecular Sequence Data; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Protein Structure, Secondary; Recombinant Proteins; Symporters | 1993 |
Aspartate and glutamate transport in unfertilized pig oocytes and blastocysts.
Topics: Animals; Aspartic Acid; Biological Transport, Active; Blastocyst; Embryonic and Fetal Development; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Oocytes; Sodium; Swine | 1993 |
The conserved residues glutamate-37, aspartate-100, and arginine-269 are important for the structural stabilization of Escherichia coli aspartate transcarbamoylase.
Topics: Amino Acid Sequence; Arginine; Aspartate Carbamoyltransferase; Aspartic Acid; Conserved Sequence; Enzyme Stability; Escherichia coli; Glutamates; Glutamic Acid; Kinetics; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Recombinant Proteins | 1993 |
Binding of magnesium in a mutant Escherichia coli alkaline phosphatase changes the rate-determining step in the reaction mechanism.
Topics: Alanine; Alkaline Phosphatase; Amino Acid Sequence; Aspartic Acid; Binding Sites; Escherichia coli; Glutamates; Glutamic Acid; Kinetics; Magnesium; Mutagenesis, Site-Directed; Nitrophenols; Organophosphorus Compounds; Protein Conformation; Recombinant Proteins; Zinc | 1993 |
Inhibition of endogenous glutamate release from hippocampal tissue by Ca2+ channel toxins.
Topics: Animals; Aspartic Acid; Calcium Channel Blockers; Calcium Channels; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Neurotransmitter Agents; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Potassium Chloride; Rats; Spider Venoms | 1993 |
Sustained changes in acetylcholine and amino acid contents of brain regions following microsphere embolism in rats.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Cerebral Cortex; Corpus Striatum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Intracranial Embolism and Thrombosis; Male; Microspheres; Rats; Rats, Wistar; Taurine; Tetrazolium Salts | 1993 |
Site-specific and compensatory mutations imply unexpected pathways for proton delivery to the QB binding site of the photosynthetic reaction center.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Benzoquinones; Binding Sites; Electron Transport; Glutamates; Glutamic Acid; Kinetics; Mutagenesis, Site-Directed; Photosynthetic Reaction Center Complex Proteins; Protein Conformation; Rhodobacter capsulatus; Spectrophotometry | 1993 |
Depolarization inactivation of dopamine neurons: terminal release characteristics.
Topics: Anesthesia, General; Animals; Aspartic Acid; Consciousness; Corpus Striatum; Dopamine; Glutamates; Glutamic Acid; Haloperidol; Male; Microdialysis; Neurons; Potassium; Rats; Rats, Sprague-Dawley; Reference Values | 1993 |
Increased aspartate and glutamate levels in both gastric and colon cancer tissues.
Topics: Aspartic Acid; Colonic Neoplasms; Gastric Mucosa; Glutamates; Glutamic Acid; Humans; Intestinal Mucosa; Protein Binding; Stomach Neoplasms | 1993 |
L-glutamate and L-aspartate concentrations in the developing and aging human putamen tissue.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Child; Child, Preschool; Female; Glutamates; Glutamic Acid; Humans; Infant; Male; Middle Aged; Putamen | 1993 |
Effects of neurotensin on the release of glutamic acid in the prefrontal cortex and striatum of the rat.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Extracellular Space; Glutamates; Glutamic Acid; Male; Neurotensin; Prefrontal Cortex; Rats; Rats, Wistar | 1993 |
Glutamate- and aspartate-like immunoreactivities in human normal and inflamed skin.
Topics: Aspartic Acid; Drug Eruptions; Glutamates; Glutamic Acid; Humans; Immunohistochemistry; Reference Values; Skin | 1993 |
The monosialoganglioside GM1 dose-dependently reduces regional cerebral metabolic rates for glucose in awake rats.
Topics: Animals; Aspartic Acid; Binding, Competitive; Brain; Dose-Response Relationship, Drug; G(M1) Ganglioside; Glucose; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred F344 | 1993 |
Proton-translocating carboxyl of subunit c of F1Fo H(+)-ATP synthase: the unique environment suggested by the pKa determined by 1H NMR.
Topics: Amino Acid Sequence; Aspartic Acid; Conserved Sequence; Escherichia coli; Glutamic Acid; Hydrogen; Kinetics; Macromolecular Substances; Magnetic Resonance Spectroscopy; Mutagenesis; Point Mutation; Protein Folding; Protein Structure, Secondary; Proton-Translocating ATPases | 1995 |
Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes.
Topics: Alanine; Animals; Aspartic Acid; Astrocytes; Biological Transport; Cell Compartmentation; Cells, Cultured; Citric Acid Cycle; Culture Media, Conditioned; Extracellular Space; Glutamic Acid; Glutamine; Lactates; Magnetic Resonance Spectroscopy; Mice; Pyruvates; Pyruvic Acid; Rats | 1996 |
The use of natural and unnatural amino acid substrates to define the substrate specificity differences of Escherichia coli aspartate and tyrosine aminotransferases.
Topics: Amino Acid Sequence; Amino Acids; Arginine; Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Cloning, Molecular; Escherichia coli; Glutamic Acid; Kinetics; Molecular Sequence Data; Substrate Specificity; Tritium; Tyrosine Transaminase | 1995 |
Adenosine modulates methylmercuric chloride (MeHgCl)-induced D-aspartate release from neonatal rat primary astrocyte cultures.
Topics: Adenosine; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Cells, Cultured; Glutamic Acid; Glutathione; Methylmercury Compounds; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theophylline; Tritium | 1995 |
Identification of two amino acid residues on the extracellular domain of the lutropin/choriogonadotropin receptor important in signaling.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Blotting, Western; Cell Line; Chlorocebus aethiops; Chorionic Gonadotropin; Cyclic AMP; DNA, Complementary; Glutamic Acid; Humans; Kinetics; Lysine; Mutagenesis, Site-Directed; Point Mutation; Rats; Receptors, LH; Recombinant Proteins; Signal Transduction; Transfection | 1995 |
Secondary elevation of extracellular neurotransmitter amino acids in the reperfusion phase following focal cerebral ischemia.
Topics: Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Basal Ganglia; Cerebral Cortex; Cerebrospinal Fluid; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Ischemic Attack, Transient; Male; Microdialysis; Neurotransmitter Agents; Rabbits; Regression Analysis; Reperfusion Injury; Taurine | 1996 |
Transient brain ischemia in rabbits: the effect of omega-conopeptide MVIIC on hippocampal excitatory amino acids.
Topics: Animals; Aspartic Acid; Blood Pressure; Calcium Channel Blockers; Electroencephalography; Excitatory Amino Acids; Female; Glutamic Acid; Hippocampus; Ischemic Attack, Transient; Male; Microdialysis; omega-Conotoxins; Peptides; Rabbits | 1995 |
A difference in the sequence of steps in the reactions catalyzed by two closely homologous forms of glutamate dehydrogenase.
Topics: Animals; Aspartic Acid; Binding Sites; Cattle; Clostridium; Glutamate Dehydrogenase; Glutamic Acid; Kinetics; Liver; Lysine; Protein Binding; Serine; Time Factors | 1996 |
L-2-chloropropionic acid-induced neurotoxicity is prevented by MK-801: possible role of NMDA receptors in the neuropathology.
Topics: Administration, Oral; Animals; Aspartic Acid; Autoradiography; Brain Edema; Cerebellum; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamic Acid; Golgi Apparatus; Hydrocarbons, Chlorinated; Injections, Intraperitoneal; Male; Motor Activity; Neuroprotective Agents; Neurotoxins; Propionates; Purkinje Fibers; Rats; Receptors, N-Methyl-D-Aspartate; Sodium; Stereoisomerism; Synaptic Transmission; Taurine | 1996 |
Changes in cerebellar amino acid neurotransmitter concentrations and receptors following administration of the neurotoxin L-2-chloropropionic acid.
Topics: Amino Acids; Animals; Aspartic Acid; Autoradiography; Binding Sites; Cerebellum; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Hydrocarbons, Chlorinated; Male; Neurotoxins; Neurotransmitter Agents; Propionates; Prosencephalon; Rats; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Synaptic Transmission; Taurine | 1996 |
Immunocytochemical localization of aspartate and glutamate in the peripheral vestibular system.
Topics: Absorption; Animals; Antibody Specificity; Aspartic Acid; Glutamic Acid; Hair Cells, Auditory, Outer; Immunohistochemistry; Male; Nerve Fibers; Rats; Rats, Sprague-Dawley; Spiral Ganglion; Staining and Labeling; Synaptic Transmission; Vestibule, Labyrinth | 1995 |
Age-related changes in the uptake and release of glutamate and aspartate in the mouse brain.
Topics: Aging; Animals; Aspartic Acid; Brain; Female; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Rats | 1995 |
Effect of lamotrigine on the electrically-evoked release of endogenous amino acids from slices of dorsal horn of the rat spinal cord.
Topics: Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dose-Response Relationship, Drug; Evoked Potentials; Glutamic Acid; Lamotrigine; Male; Morphine; Rats; Rats, Wistar; Spinal Cord; Triazines | 1995 |
Catalytic properties and structural components of lysyl oxidase.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Blotting, Western; Catalysis; Cattle; CHO Cells; Collagen; Cricetinae; Elastin; Gene Expression Regulation, Enzymologic; Glutamic Acid; Humans; Lysine; Molecular Sequence Data; Oxidation-Reduction; Protein Processing, Post-Translational; Protein-Lysine 6-Oxidase; Recombinant Proteins; RNA, Messenger; Substrate Specificity | 1995 |
Effect of alpha 2-adrenergic drugs dexmedetomidine and atipamezole on extracellular amino acid levels in vivo.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amino Acids; Animals; Aspartic Acid; Calcium; Epilepsy; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Imidazoles; Male; Medetomidine; Microdialysis; Potassium; Rats; Rats, Wistar; Seizures; Spectrometry, Fluorescence | 1995 |
Lowered brain glutathione by diethylmaleate decreased the glutamate release induced by cerebral ischemia in anesthetized rats.
Topics: Anesthetics; Animals; Aspartic Acid; Brain; Brain Ischemia; Glutamic Acid; Glutathione; In Vitro Techniques; Male; Maleates; Microdialysis; Rats; Rats, Sprague-Dawley | 1995 |
The release of glutamate and aspartate from rat brain synaptosomes in response to domoic acid (amnesic shellfish toxin) and kainic acid.
Topics: Animals; Aspartic Acid; Brain; Glutamic Acid; Kainic Acid; Male; Marine Toxins; Neurotoxins; Rats; Rats, Sprague-Dawley; Synaptosomes | 1995 |
Novel separation scheme for capillary electrophoresis of enantiomers.
Topics: Aspartic Acid; Buffers; Cyclodextrins; Dansyl Compounds; Electrophoresis, Capillary; Glutamic Acid; Hydrogen-Ion Concentration; Ibuprofen; Metaproterenol; Methamphetamine; Naproxen; Pharmaceutical Preparations; Stereoisomerism | 1995 |
Presence of D-aspartate and D-glutamate in tumor proteins.
Topics: Aspartic Acid; Glutamic Acid; Humans; Neoplasm Proteins; Neoplasms; Stereoisomerism | 1995 |
Analogue of aspartate and glutamate active at synapses are attractants for Escherichia coli.
Topics: Animals; Aspartic Acid; Chemotactic Factors; Chemotaxis; Escherichia coli; Glutamic Acid; Structure-Activity Relationship; Synapses | 1995 |
Protein selectivity in immobilized metal affinity chromatography based on the surface accessibility of aspartic and glutamic acid residues.
Topics: Animals; Aspartic Acid; Buffers; Chickens; Chromatography, Affinity; Cytochrome c Group; Dogs; Female; Glutamic Acid; Horses; Hydrogen-Ion Concentration; Imino Acids; Metals; Muramidase; Myoglobin; Proteins; Sepharose; Sheep; Species Specificity; Surface Properties | 1995 |
Origins of life. Primordial soup or crêpes?
Topics: Aspartic Acid; Glutamic Acid; Models, Biological; Oligonucleotides; Origin of Life; Peptides; Polymers; Solutions; Surface Properties | 1996 |
Potentiation of proton transfer function by electrostatic interactions in photosynthetic reaction centers from Rhodobacter sphaeroides: First results from site-directed mutation of the H subunit.
Topics: Amino Acid Sequence; Aspartic Acid; Azides; Base Sequence; Binding Sites; Cytochromes; Electrochemistry; Electron Transport; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Photochemistry; Photosynthetic Reaction Center Complex Proteins; Point Mutation; Quinones; Recombinant Proteins; Rhodobacter sphaeroides | 1996 |
Neurochemical monitoring using intracerebral microdialysis in patients with subarachnoid hemorrhage.
Topics: Aged; Aspartic Acid; Brain Chemistry; Female; Glutamic Acid; Humans; Hypoxanthine; Hypoxanthines; Lactates; Male; Microdialysis; Middle Aged; Subarachnoid Hemorrhage; Tomography, X-Ray Computed | 1996 |
Nitric oxide regulates excitatory amino acid release in a biphasic manner in freely moving rats.
Topics: Animals; Arginine; Aspartic Acid; Enzyme Inhibitors; Excitatory Amino Acids; Glutamic Acid; Hippocampus; Male; Microdialysis; Motor Activity; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penicillamine; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents | 1995 |
Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization.
Topics: Analysis of Variance; Animals; Aspartic Acid; Body Temperature; Brain Ischemia; Cerebral Cortex; Electroencephalography; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Heart Arrest; Hypothermia, Induced; Male; Membrane Potentials; Microdialysis; Rats; Rats, Sprague-Dawley | 1996 |
Quantitative changes of amino acid distributions in the rat vestibular nuclear complex after unilateral vestibular ganglionectomy.
Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; gamma-Aminobutyric Acid; Ganglionectomy; Glutamic Acid; Glutamine; Glycine; Male; Nerve Degeneration; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Taurine; Vestibular Nuclei | 1996 |
On the origin of extracellular glutamate levels monitored in the basal ganglia of the rat by in vivo microdialysis.
Topics: Amino Acids; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Aspartic Acid; Basal Ganglia; Calcium; Cerebral Cortex; Dicarboxylic Acids; Glutamic Acid; Halothane; Kainic Acid; Male; Membrane Potentials; Microdialysis; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Potassium; Presynaptic Terminals; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Spider Venoms; Substantia Nigra; Tetrodotoxin; Urethane | 1996 |
Extracellular striatal dopamine and glutamate after decortication and kainate receptor stimulation, as measured by microdialysis.
Topics: Animals; Aspartic Acid; Cerebral Decortication; Dopamine; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Kainic Acid; Male; Microdialysis; Neostriatum; Rats; Rats, Wistar; Receptors, Kainic Acid | 1996 |
Oxidative stress, hypoxia, and ischemia-like conditions increase the release of endogenous amino acids by distinct mechanisms in cultured retinal cells.
Topics: Adenosine Monophosphate; Alanine; Amino Acids; Animals; Arachidonic Acid; Ascorbic Acid; Aspartic Acid; Calcium; Cell Death; Cell Hypoxia; Cells, Cultured; Chick Embryo; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Iron; Membrane Potentials; Neurotoxins; Oxidative Stress; Retina; Taurine; Tritium | 1996 |
Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis.
Topics: Amino Acid Sequence; Animals; Arthritis, Experimental; Aspartic Acid; Cartilage; Cells, Cultured; Collagen; Disease Susceptibility; Epitopes; Glutamic Acid; Immune Tolerance; Interferon-gamma; Lymph Nodes; Lymphocyte Activation; Male; Mice; Mice, Inbred C3H; Mice, Transgenic; Molecular Sequence Data; Mutagenesis, Site-Directed; Organ Specificity; Point Mutation; Polymerase Chain Reaction; Rats; T-Lymphocytes; Time Factors | 1996 |
Functional geometry of amino acid sensitive membrane of layer V neurons in the guinea-pig neocortex in vitro.
Topics: Animals; Aspartic Acid; Cell Membrane; Cerebral Cortex; Dendrites; Electrophysiology; Female; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Iontophoresis; Male; Neurons; Reaction Time | 1995 |
Response of LLC-PK1-F+ cells to metabolic acidosis.
Topics: Acidosis; Animals; Aspartic Acid; Bicarbonates; Biological Transport; gamma-Glutamyltransferase; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Kinetics; LLC-PK1 Cells; Models, Biological; Swine | 1996 |
D38 is an essential part of the proton translocation pathway in bacteriorhodopsin.
Topics: Amino Acid Sequence; Aspartic Acid; Bacteriorhodopsins; Cysteine; Glutamic Acid; Halobacterium; Hydrogen-Ion Concentration; Kinetics; Light; Models, Structural; Mutagenesis, Site-Directed; Point Mutation; Protein Structure, Secondary; Recombinant Proteins; Spectrophotometry; Spectroscopy, Fourier Transform Infrared | 1996 |
Neuroexcitatory amino acids and their relation to infarct size and neurological deficit in ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Cerebrovascular Disorders; Chromatography, High Pressure Liquid; Excitatory Amino Acids; Female; Glutamic Acid; Glycine; Humans; Logistic Models; Male; Middle Aged; Neurologic Examination; Severity of Illness Index; Taurine; Tomography, X-Ray Computed | 1996 |
Effects of a vigilance-enhancing drug, modafinil, on rat brain metabolism: a 2D COSY 1H-NMR study.
Topics: Animals; Aspartic Acid; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Cognition; Creatine; Glutamic Acid; Inositol; Magnetic Resonance Spectroscopy; Male; Modafinil; Phosphocreatine; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity | 1995 |
Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.
Topics: Asparagine; Aspartic Acid; Binding Sites; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Electrochemistry; Glutamic Acid; Glycine; Humans; Hydrazines; Imines; Mixed Function Oxygenases; Models, Molecular; Molecular Structure; Mutation; Protoporphyrins; Saccharomyces cerevisiae; Structure-Activity Relationship | 1996 |
Modification of the pH profile and tetrabenazine sensitivity of rat VMAT1 by replacement of aspartate 404 with glutamate.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Biological Transport; Catalysis; Cell Line; Glutamic Acid; Hydrogen-Ion Concentration; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Neuropeptides; Rats; Serotonin; Tetrabenazine; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1996 |
Tetanus toxin-induced effects on extracellular amino acid levels in rat hippocampus: an in vivo microdialysis study.
Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; Dentate Gyrus; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Microinjections; Neurons; Potassium; Rats; Rats, Wistar; Tetanus Toxin | 1996 |
Acute and repeated systemic amphetamine administration: effects on extracellular glutamate, aspartate, and serine levels in rat ventral tegmental area and nucleus accumbens.
Topics: Amino Acids; Amphetamine; Animals; Aspartic Acid; Calcium; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Extracellular Space; Glutamic Acid; Male; Microdialysis; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Serine; Time Factors; Ventral Tegmental Area | 1996 |
A linkage of the pKa's of asp-85 and glu-204 forms part of the reprotonation switch of bacteriorhodopsin.
Topics: Amino Acid Sequence; Aspartic Acid; Bacteriorhodopsins; Glutamic Acid; Halobacterium; Hydrogen-Ion Concentration; Kinetics; Light; Models, Molecular; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Schiff Bases; Thermodynamics | 1996 |
Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase.
Topics: Adenosine Deaminase; Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Calorimetry; Chromatography, DEAE-Cellulose; Chromatography, High Pressure Liquid; Circular Dichroism; Conserved Sequence; Glutamic Acid; Kinetics; Mice; Models, Molecular; Mutagenesis, Site-Directed; Point Mutation; Protein Structure, Secondary; Recombinant Proteins; Substrate Specificity | 1996 |
Ty3 integrase mutants defective in reverse transcription or 3'-end processing of extrachromosomal Ty3 DNA.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; DNA Nucleotidyltransferases; DNA, Fungal; Glutamic Acid; Integrases; Molecular Sequence Data; Mutation; Retroelements; RNA-Directed DNA Polymerase; Saccharomyces cerevisiae; Sequence Deletion; Transcription, Genetic | 1996 |
A use-dependent sodium channel antagonist, 619C89, in reduction of ischemic brain damage and glutamate release after acute subdural hematoma in the rat.
Topics: Animals; Aspartic Acid; Brain Ischemia; Dialysis; Disease Models, Animal; Glutamic Acid; Hematoma, Subdural; Male; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Threonine | 1996 |
Proton magnetic resonance spectroscopy in Huntington's disease: evidence in favour of the glutamate excitotoxic theory.
Topics: Aspartic Acid; Cerebral Cortex; Corpus Striatum; Genetic Carrier Screening; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Imaging; Nerve Degeneration; Reference Values; Synaptic Transmission | 1996 |
Selective activation of calcium permeability by aspartate in Purkinje cells.
Topics: Animals; Aspartic Acid; Calcium; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Homocysteine; Magnesium; Mice; Mice, Knockout; N-Methylaspartate; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Permeability; Purkinje Cells; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate | 1996 |
Effects of hypothermia, pentobarbital, and isoflurane on postdepolarization amino acid release during complete global cerebral ischemia.
Topics: Anesthetics, Inhalation; Animals; Aspartic Acid; Brain Ischemia; Calcium; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hypnotics and Sedatives; Hypothermia, Induced; Isoflurane; Male; Pentobarbital; Rats; Rats, Sprague-Dawley | 1996 |
Mutation of the catalytic site Asp177 to Glu177 in human pancreatic lipase produces an active lipase with increased sensitivity to proteases.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Baculoviridae; Binding Sites; Cell Line; Endopeptidases; Gene Expression; Glutamic Acid; Humans; Lipase; Molecular Sequence Data; Mutagenesis, Site-Directed; Pancreas; Protein Denaturation; Spodoptera; Transfection; Urea | 1996 |
Ligand binding to integrin alphaIIbbeta3 is dependent on a MIDAS-like domain in the beta3 subunit.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Glutamic Acid; Humans; Mice; Molecular Sequence Data; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine | 1996 |
The role of acidic amino acid residues in the structural stability of snake cardiotoxins.
Topics: Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Circular Dichroism; Cobra Cardiotoxin Proteins; Disulfides; Glutamic Acid; Guanidine; Guanidines; Hydrogen Bonding; Hydrogen-Ion Concentration; Lysine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Trifluoroethanol | 1996 |
Evidence that residues exposed on the three-fold channels have active roles in the mechanism of ferritin iron incorporation.
Topics: Alanine; Apoferritins; Aspartic Acid; Ceruloplasmin; Ferric Compounds; Ferritins; Glutamic Acid; Humans; Iron; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Structure-Activity Relationship; Terbium; Titrimetry | 1996 |
Similar localization of immunoreactive glutamate and aspartate in the pineal organ and retina of various nonmammalian vertebrates.
Topics: Amphibians; Animals; Aspartic Acid; Birds; Fishes; Glutamic Acid; Immunohistochemistry; Microscopy, Immunoelectron; Pineal Gland; Reptiles; Retina | 1995 |
Mitochondrial phosphate transport protein. replacements of glutamic, aspartic, and histidine residues affect transport and protein conformation and point to a coupled proton transport path.
Topics: Amino Acid Sequence; Aspartic Acid; Carrier Proteins; Glutamic Acid; Histidine; Ion Transport; Molecular Sequence Data; Mutagenesis; Phosphate-Binding Proteins; Phosphates; Protein Conformation; Protons; Sequence Homology, Amino Acid | 1996 |
The entry of acidic amino acids into brain and CSF during development, using in situ perfusion in the rat.
Topics: Animals; Animals, Newborn; Aspartic Acid; Blood-Brain Barrier; Brain; Carotid Arteries; Coronary Circulation; Female; Glutamic Acid; Perfusion; Rats; Rats, Wistar | 1995 |
The effect of the desglycinyl metabolite of remacemide hydrochloride (FPL 12495AA) and dizocilpine (MK-801) on endogenous amino acid release from mouse cortex.
Topics: Acetamides; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Phenethylamines; Potassium; Veratridine | 1995 |
Studies on the identity of the rat optic nerve transmitter.
Topics: Amino Acids, Sulfur; Animals; Aspartic Acid; Denervation; Excitatory Amino Acids; Glutamic Acid; In Vitro Techniques; Nerve Fibers; Neural Pathways; Neuropeptides; Neurotransmitter Agents; Optic Nerve; Rats; Rats, Sprague-Dawley; Superior Colliculi; Synaptic Transmission | 1996 |
Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep.
Topics: Animals; Aspartic Acid; Brain Edema; Brain Ischemia; Cytotoxins; Electroencephalography; Extracellular Space; Female; Fetal Hypoxia; gamma-Aminobutyric Acid; Gestational Age; Glutamic Acid; Hypoxia, Brain; Nitric Oxide; Pregnancy; Reperfusion Injury; Seizures; Sheep; Time Factors | 1996 |
Effects of ammonia on L-glutamate uptake in cultured astrocytes.
Topics: Ammonia; Animals; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; Kinetics; Rats | 1996 |
Metabolism of N-acetyl-L-aspartate in rat brain.
Topics: Animals; Aspartic Acid; Biotransformation; Brain; Deuterium; Female; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Kinetics; Nitrogen Isotopes; Rats; Rats, Inbred F344; Time Factors | 1996 |
Glutamate metabolic pathways in displaced ganglion cells of the chicken retina.
Topics: Aerobiosis; Anaerobiosis; Animals; Aspartic Acid; Cell Size; Chickens; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Image Processing, Computer-Assisted; Immunohistochemistry; Retinal Ganglion Cells; Tissue Fixation | 1996 |
T1 and T2 relaxation times of the major 1H-containing metabolites in rat brain after focal ischemia.
Topics: Animals; Aspartic Acid; Brain; Choline; Creatine; Glutamic Acid; Glutamine; Ischemic Attack, Transient; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Rats | 1995 |
Possible role of nitric oxide in the development of L-2-chloropropionic acid-induced cerebellar granule cell necrosis.
Topics: Animals; Aspartic Acid; Cerebellum; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hydrocarbons, Chlorinated; In Vitro Techniques; Indazoles; Male; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Ornithine; Propionates; Rats | 1996 |
L-Glutamate-induced responses in OFF-type bipolar cells of the cat retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Calcium; Cats; Chlorides; Cycloleucine; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; In Vitro Techniques; Ion Transport; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium; Retina; Retinal Cone Photoreceptor Cells; Sodium | 1996 |
Interaction between anionic amino acids and the mammary tissue (Na(+)-glutamate) cotransporter.
Topics: Aging; Amino Acid Transport System X-AG; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Carrier Proteins; Female; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Mammary Glands, Animal; Organ Culture Techniques; Rats; Rats, Wistar; Sucrose; Symporters | 1996 |
Changes in the intracellular free amino acid pool in human saphenous vein tissue culture.
Topics: Aged; Alanine; Amino Acids; Asparagine; Aspartic Acid; Culture Techniques; Cytosol; Glutamic Acid; Glutamine; Glycine; Humans; Middle Aged; Proline; Saphenous Vein; Serine; Taurine | 1996 |
Origin of aspartate-induced responses in rat cerebellar Purkinje cells.
Topics: Animals; Aspartic Acid; Glutamic Acid; Interneurons; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, N-Methyl-D-Aspartate | 1996 |
Woodward's reagent K inactivation of Escherichia coli L-threonine dehydrogenase: increased absorbance at 340-350 nm is due to modification of cysteine and histidine residues, not aspartate or glutamate carboxyl groups.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Cysteine; Enzyme Inhibitors; Escherichia coli; Glutamic Acid; Histidine; Isoxazoles; Kinetics; Models, Chemical; Molecular Sequence Data; Solvents; Spectrophotometry, Ultraviolet; Sulfhydryl Compounds | 1996 |
The modulatory effect of melatonin on the dopamine-glutamate interaction in the anterior hypothalamus during ageing.
Topics: Aging; Amphetamine; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dopamine; Dopamine Agents; Extracellular Space; Glutamic Acid; Hypothalamus, Anterior; Male; Melatonin; Rats; Rats, Wistar | 1995 |
Intracerebral microdialysis of glutamate and aspartate in two vascular territories after aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Aneurysm, Ruptured; Aspartic Acid; Brain Ischemia; Female; Frontal Lobe; Glutamic Acid; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; Microdialysis; Middle Aged; Monitoring, Physiologic; Postoperative Complications; Prognosis; Subarachnoid Hemorrhage; Synaptic Transmission; Temporal Lobe; Tomography, X-Ray Computed | 1996 |
Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetylaspartate, glutamate, and GABA content of the epileptic human brain.
Topics: Aspartic Acid; Astrocytes; Biopsy; Creatine; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Neurons; Synaptic Transmission; Temporal Lobe | 1995 |
Effects of both shortening and lengthening the active site nucleophile of Bacillus circulans xylanase on catalytic activity.
Topics: Amino Acid Sequence; Aspartic Acid; Bacillus; Base Sequence; Binding Sites; Carbohydrate Conformation; Carbohydrate Sequence; Catalysis; Cysteine; Glutamic Acid; Glycoside Hydrolases; Glycosylation; Iodoacetates; Iodoacetic Acid; Kinetics; Mass Spectrometry; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Xylan Endo-1,3-beta-Xylosidase; Xylosidases | 1996 |
Monoclonal antibody 4B1 alters the pKa of a carboxylic acid at position 325 (helix X) of the lactose permease of Escherichia coli.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Aspartic Acid; Cell Membrane; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Membrane Transport Proteins; Models, Biological; Models, Structural; Molecular Sequence Data; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Point Mutation; Protein Structure, Secondary; Recombinant Proteins; Symporters | 1996 |
Mechanisms of H+ and Na+ changes induced by glutamate, kainate, and D-aspartate in rat hippocampal astrocytes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Bicarbonates; Buffers; Carbon Dioxide; Glutamic Acid; Hippocampus; Hydrogen; Kainic Acid; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Sodium; Sodium Chloride | 1996 |
Glutamate is transported across the rat blood-brain barrier by a sodium-independent system.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Cystine; Glutamic Acid; Perfusion; Rats; Rats, Sprague-Dawley; Sodium; Time Factors | 1996 |
Transmembrane glutamic acid residues play essential roles in the metal-tetracycline/H+ antiporter of Staphylococcus aureus.
Topics: Amino Acid Sequence; Antiporters; Aspartic Acid; Bacterial Proteins; Glutamic Acid; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Staphylococcus aureus; Tetracycline; Tetracycline Resistance | 1996 |
Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Aspartic Acid; Calcium; Cell Line; Glutamic Acid; GTP-Binding Proteins; Mice; Molecular Sequence Data; Phosphorylation; Protein Kinase C; Rats; Receptors, AMPA; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Threonine; Transfection | 1996 |
New mutations and phenotypes associated with glutamate and aspartate transport in Chinese hamster ovary (CHO-K1) cells.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Brain Chemistry; Carrier Proteins; Cell Membrane; Cell Membrane Permeability; CHO Cells; Cricetinae; Excitatory Amino Acid Transporter 1; Genetic Complementation Test; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glycerol; Glycoproteins; Hybrid Cells; Kinetics; Mice; Mutation; Phenotype; RNA, Messenger; Symporters; Urea; Water | 1996 |
Differential sensitivity of neonatal rat astrocyte cultures to mercuric chloride (MC) and methylmercury (MeHg): studies on K+ and amino acid transport and metallothionein (MT) induction.
Topics: Animals; Aspartic Acid; Astrocytes; Dose-Response Relationship, Drug; Glutamic Acid; Mercuric Chloride; Metallothionein; Methylmercury Compounds; Potassium; Rats; Rats, Sprague-Dawley | 1996 |
Noise analysis of the glutamate-activated current in photoreceptors.
Topics: Ambystoma; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport, Active; Biophysical Phenomena; Biophysics; Carrier Proteins; Chloride Channels; Electric Conductivity; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; In Vitro Techniques; Ion Channel Gating; Kinetics; Ligands; Mathematics; Models, Biological; Photoreceptor Cells; Retinal Rod Photoreceptor Cells; Sodium; Symporters | 1996 |
Amino acid concentrations and selected enzyme activities in rat auditory, olfactory, and visual systems.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Aspartic Acid; Auditory Cortex; Choline O-Acetyltransferase; Glutamic Acid; Glutaminase; L-Lactate Dehydrogenase; Malate Dehydrogenase; Olfactory Pathways; Rats; Tissue Distribution; Visual Cortex | 1995 |
Regulation of mitochondrial and cytosolic malic enzymes from cultured rat brain astrocytes.
Topics: Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Citrates; Citric Acid; Cytosol; Glutamic Acid; Homeostasis; Ketoglutaric Acids; Lactates; Lactic Acid; Malate Dehydrogenase; Malates; Mitochondria; Rats | 1995 |
Evidence for release of glutamic acid, aspartic acid and substance P but not gamma-aminobutyric acid from primary afferent fibres in rat spinal cord.
Topics: Afferent Pathways; Animals; Aspartic Acid; Autoradiography; Capsaicin; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Rats; Rats, Wistar; Receptors, GABA-B; Spinal Cord; Substance P | 1996 |
Inhibition of glutamate uptake induces progressive accumulation of extracellular glutamate and neuronal damage in rat cortical cultures.
Topics: Animals; Anti-Bacterial Agents; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Kainic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1996 |
Effects of glutamic acid and related agents on horizontal cells in a marine teleost retina.
Topics: Animals; Aspartic Acid; Dark Adaptation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fishes; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; Photoreceptor Cells; Quinoxalines; Receptors, Glutamate; Retina | 1996 |
Spectroscopic imaging of human brain glutamate by water-suppressed J-refocused coherence transfer at 4.1 T.
Topics: Aspartic Acid; Body Water; Brain; Carbon; Electron Spin Resonance Spectroscopy; Energy Transfer; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Models, Chemical; Phantoms, Imaging; Signal Processing, Computer-Assisted | 1996 |
Quadrupole ion trap mass spectrometry.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensinogen; Aspartic Acid; Electrophoresis, Capillary; Enkephalins; Glutamic Acid; Gramicidin; Growth Hormone-Releasing Hormone; Humans; Lactalbumin; Mass Spectrometry; Molecular Sequence Data; Molecular Weight; Myocardium; Myoglobin; Peptides; Poly A; Recombinant Proteins; Sequence Analysis | 1996 |
Analysis of the active center of branching enzyme II from maize endosperm.
Topics: 1,4-alpha-Glucan Branching Enzyme; Amino Acid Sequence; Amylose; Animals; Aspartic Acid; Base Sequence; Binding Sites; Conserved Sequence; DNA Primers; DNA, Recombinant; Escherichia coli; Ethyldimethylaminopropyl Carbodiimide; Gene Expression; Glutamic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphorylase a; Plasmids; Rabbits; Recombinant Proteins; Sequence Alignment; Zea mays | 1996 |
Serum affects the characteristics of excitatory amino acid-binding sites on Müller cells.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Blood Proteins; Cattle; Cells, Cultured; Chick Embryo; Culture Media; Excitatory Amino Acids; Glutamic Acid; Kinetics; Membrane Proteins; Neuroglia; Receptors, Glutamate; Retina; Tritium | 1996 |
Photoperiodic modulation of monoamines and amino-acids involved in the control of prolactin and LH secretion in the ewe: evidence for a regulation of tyrosine hydroxylase activity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Biogenic Monoamines; Dopamine; Estradiol; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamus; Luteinizing Hormone; Median Eminence; Ovariectomy; Photoperiod; Preoptic Area; Prolactin; Sheep; Tyrosine 3-Monooxygenase | 1996 |
A glutamate/glutamine/aspartate/asparagine transport operon in Rhodobacter capsulatus.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Asparagine; Aspartic Acid; Biological Transport; Carrier Proteins; Chromosome Mapping; Cloning, Molecular; Glutamic Acid; Glutamine; Molecular Sequence Data; Operon; Rhodobacter capsulatus; Sequence Homology, Amino Acid | 1996 |
Glutamate and aspartate immunoreactive neurons of the rat basolateral amygdala: colocalization of excitatory amino acids and projections to the limbic circuit.
Topics: Amygdala; Animals; Antibody Specificity; Aspartic Acid; Corpus Striatum; Glutamic Acid; Immunohistochemistry; Limbic System; Male; Neural Pathways; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Thalamic Nuclei | 1996 |
Amino acid signatures in the primate retina.
Topics: Amino Acids; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Image Processing, Computer-Assisted; Immunohistochemistry; Macaca fascicularis; Male; Pattern Recognition, Automated; Peptide Mapping; Photoreceptor Cells; Protein Precursors; Retina; Retinal Ganglion Cells; Taurine | 1996 |
Metabotropic glutamate receptors, transmitter output and fatty acids: studies in rat brain slices.
Topics: Acetophenones; Animals; Arachidonic Acid; Aspartic Acid; Corpus Striatum; Cyclohexanones; Cycloleucine; Cyclooxygenase Inhibitors; Fatty Acids; Glutamic Acid; In Vitro Techniques; Indomethacin; Lipoprotein Lipase; Male; Masoprocol; Membrane Potentials; Neurotoxins; Oleic Acids; Parietal Lobe; Phospholipases A; Phospholipases A2; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Serum Albumin; Stearic Acids | 1996 |
Excitatory amino acid concentrations in the spinal dorsal horn of cats during muscle contraction.
Topics: Animals; Aspartic Acid; Blood Pressure; Cats; Chromatography, High Pressure Liquid; Electric Stimulation; Excitatory Amino Acids; Extracellular Space; Glutamic Acid; Heart Rate; Hindlimb; Isometric Contraction; Microdialysis; Muscle Contraction; Muscle, Skeletal; Spinal Cord | 1996 |
Role of PM-ATPase, amino acid transport and free amino acid pool in the salt stress of, Candida membranefaciens.
Topics: Adenosine Triphosphatases; Amino Acids; Aspartic Acid; Biological Transport; Candida; Cell Membrane; Glutamic Acid; Homeostasis; Osmotic Pressure; Protons; Saccharomyces cerevisiae; Saline Solution, Hypertonic | 1996 |
Differences in the release of L-glutamate and D-aspartate from primary neuronal chick cultures.
Topics: Animals; Aspartic Acid; Biological Transport; Cells, Cultured; Chick Embryo; Drug Evaluation, Preclinical; Exocytosis; Glutamates; Glutamic Acid; Kainic Acid; Neurons | 1996 |
Effects of uptake carrier blockers SK & F 89976-A and L-trans-PDC on in vivo release of amino acids in rat hippocampus.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Dicarboxylic Acids; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Potassium; Pyrrolidines; Rats; Rats, Wistar; Taurine | 1996 |
Gamma-glutamyl peptides and related amino acids in rat hippocampus in vitro: effect of depolarization and gamma-glutamyl transpeptidase inhibition.
Topics: Amino Acids; Animals; Aspartic Acid; Cysteine; Dipeptides; Enzyme Inhibitors; Female; gamma-Glutamyltransferase; Glutamates; Glutamic Acid; Glutamine; Glutathione; Hippocampus; Isoxazoles; Male; Rats; Rats, Sprague-Dawley | 1996 |
Pharmacology of N-methyl-D-aspartate-evoked [3H]noradrenaline release in adult rat spinal cord.
Topics: Animals; Aspartic Acid; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tritium | 1996 |
Modulation of excitatory synaptic transmission by low concentrations of glutamate in cultured rat hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic Acid; Benzothiadiazines; Calcium; Cells, Cultured; Cycloleucine; Evoked Potentials; Glutamic Acid; Hippocampus; Neurons; Patch-Clamp Techniques; Pertussis Toxin; Rats; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Virulence Factors, Bordetella; Wheat Germ Agglutinins | 1996 |
Selected P2 purinoceptor modulators prevent glutamate-evoked cytotoxicity in cultured cerebellar granule neurons.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Animals, Newborn; Aspartic Acid; Biological Transport; Calcium; Cell Death; Cell Membrane; Cell Survival; Cells, Cultured; Cerebellum; Enzyme Inhibitors; Glutamic Acid; Neurons; Phosphorylation; Rats; Rats, Wistar; Receptors, Purinergic P2; Triazines | 1996 |
Ion channel properties of a protein complex with characteristics of a glutamate/N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding Sites; Brain; Calcium; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ion Channels; Lipid Bilayers; Liposomes; Patch-Clamp Techniques; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1996 |
Circadian rhythm and response to light of extracellular glutamate and aspartate in rat suprachiasmatic nucleus.
Topics: Anesthesia; Animals; Aspartic Acid; Circadian Rhythm; Extracellular Space; Glutamic Acid; Hypothalamus; Light; Male; Microdialysis; Photic Stimulation; Photoperiod; Rats; Rats, Wistar; Suprachiasmatic Nucleus; Urethane | 1996 |
The role of glutamate reuptake in regulation of glutamate responses in Aplysia neurons.
Topics: Animals; Aplysia; Aspartic Acid; Binding, Competitive; Biological Transport, Active; Cysteic Acid; Ganglia, Invertebrate; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Neurons; Receptors, Glutamate | 1995 |
Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure.
Topics: Animals; Aspartic Acid; Brain Chemistry; Excitatory Amino Acids; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Hepatic Encephalopathy; Male; Microdialysis; Rats; Rats, Sprague-Dawley | 1996 |
Dietary glutamine supplementation prevents jejunal atrophy in weaned pigs.
Topics: Alanine; Animals; Aspartic Acid; Atrophy; Diet; Disease Models, Animal; Duodenum; Epithelium; Female; Glutamic Acid; Glutamine; Intestinal Diseases; Jejunum; Male; Stomach; Swine; Swine Diseases; Taurine; Weaning | 1996 |
Effect of carbamazepine, oxcarbazepine and lamotrigine on the increase in extracellular glutamate elicited by veratridine in rat cortex and striatum.
Topics: Animals; Anticonvulsants; Aspartic Acid; Carbamazepine; Cerebral Cortex; Corpus Striatum; Glutamic Acid; Lamotrigine; Male; Microdialysis; Oxcarbazepine; Rats; Triazines; Veratridine | 1996 |
Influence of dietary fiber consumption on oxidative metabolism and anaplerotic flux in isolated rat colonocytes.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Carbon Dioxide; Citric Acid Cycle; Colon; Diet; Dietary Fiber; Eating; Fatty Acids; Glucose; Glutamic Acid; In Vitro Techniques; Male; Oxygen Consumption; Rats; Rats, Sprague-Dawley | 1996 |
Activation of N-methyl-D-aspartate receptors by glycine: role of an aspartate residue in the M3-M4 loop of the NR1 subunit.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Extracellular Space; Glutamic Acid; Glycine; Macromolecular Substances; Magnesium; Molecular Sequence Data; Mutation; Protein Folding; Receptors, N-Methyl-D-Aspartate; Sensitivity and Specificity | 1996 |
Immunohistochemical localization of neurotransmitters utilized by neurons in the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF) that project to the oculomotor and trochlear nuclei in the cat.
Topics: Animals; Aspartic Acid; Cats; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Neurotransmitter Agents; Oculomotor Nerve; Trochlear Nerve | 1996 |
A large compressibility change of protein induced by a single amino acid substitution.
Topics: Aspartate Aminotransferases; Aspartic Acid; Escherichia coli; Glutamic Acid; Glycine; Linear Models; NADP; Phenylalanine; Point Mutation; Proteins; Pyridoxal Phosphate; Tetrahydrofolate Dehydrogenase; Valine | 1996 |
The development of excitatory transmitter amino acid-containing neurons in the rat visual cortex. A light and electron microscopic immunocytochemical study.
Topics: Animals; Aspartic Acid; Glutamic Acid; Immunohistochemistry; Microscopy; Microscopy, Immunoelectron; Neurons; Rats; Rats, Sprague-Dawley; Visual Cortex | 1996 |
Free alanine, aspartic acid, or glutamic acid reduce the glycation of human lens proteins.
Topics: Alanine; Aspartic Acid; Crystallins; Glutamic Acid; Glycosylation; Humans | 1996 |
Additivity of apparent and true ileal amino acid digestibilities in soybean meal, sunflower meal, and meat and bone meal for broilers.
Topics: Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Biological Products; Chickens; Digestion; Female; Glutamic Acid; Glycine max; Helianthus; Homoarginine; Ileum; Isoleucine; Meat; Minerals; Predictive Value of Tests; Serine; Tyrosine | 1996 |
Neurotransmitter amino acids in cerebrospinal fluid of patients with Parkinson's disease.
Topics: Aged; Amino Acids; Asparagine; Aspartic Acid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Humans; Male; Middle Aged; Neurotransmitter Agents; Parkinson Disease | 1996 |
Mechanisms of glutamate and aspartate release in the ischemic rat cerebral cortex.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Glutamic Acid; Lipoxygenase Inhibitors; Male; Phospholipases; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley | 1996 |
In vivo elevation of extracellular potassium in the rat amygdala increases extracellular glutamate and aspartate and damages neurons.
Topics: Amygdala; Animals; Aspartic Acid; Brain Edema; Extracellular Space; Glutamic Acid; Glutamine; Glycine; Kinetics; Male; Microdialysis; Neurons; Potassium; Potassium Chloride; Rats; Rats, Wistar; Serine; Taurine | 1996 |
Modulation of neurotransmitter release by cholecystokinin in the neostriatum and substantia nigra of the rat: regional and receptor specificity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Cholecystokinin; Dopamine; Dynorphins; Endorphins; gamma-Aminobutyric Acid; Glutamic Acid; Homovanillic Acid; Kinetics; Male; Neostriatum; Neurons; Neurotransmitter Agents; Organ Specificity; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Substantia Nigra; Time Factors | 1996 |
Glutamatergic connections of the auditory midbrain: selective uptake and axonal transport of D-[3H]aspartate.
Topics: Animals; Aspartic Acid; Auditory Pathways; Axonal Transport; Chinchilla; Female; Glutamic Acid; Male; Mesencephalon; Microinjections; Presynaptic Terminals; Prosencephalon; Rhombencephalon; Stereoisomerism; Tritium | 1996 |
Anatomical evidence for glutamate and/or aspartate as neurotransmitters in the geniculo-, claustro-, and cortico-cortical pathways to the cat striate cortex.
Topics: Afferent Pathways; Animals; Aspartic Acid; Basal Ganglia; Cats; Functional Laterality; Geniculate Bodies; Glutamic Acid; Visual Cortex; Visual Pathways; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 1996 |
Distribution of D-aspartate oxidase and free D-glutamate and D-aspartate in chicken and pigeon tissues.
Topics: Amino Acid Oxidoreductases; Animals; Aspartic Acid; Chickens; Chromatography, High Pressure Liquid; Columbidae; D-Aspartate Oxidase; Female; Glutamic Acid; Kidney; Male; Substrate Specificity; Tissue Distribution | 1996 |
MRS study of glutamate metabolism in cultured neurons/glia.
Topics: Animals; Aspartic Acid; Carbon Radioisotopes; Cells, Cultured; Cerebellum; Citric Acid Cycle; Embryo, Mammalian; gamma-Aminobutyric Acid; Glutamic Acid; Lactates; Magnetic Resonance Spectroscopy; Mice; Neuroglia; Neurons; Prefrontal Cortex; Radioisotope Dilution Technique; Succinates | 1996 |
Regional and developmental variations in metabolite concentration in the rat brain and eye: a study using 1H NMR spectroscopy and high performance liquid chromatography.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; Corpus Callosum; Dipeptides; Eye; gamma-Aminobutyric Acid; Glutamic Acid; Hydrogen; Magnetic Resonance Spectroscopy; Olfactory Bulb; Oligodendroglia; Optic Nerve; Organ Specificity; Rats; Stem Cells | 1996 |
13C isotopomer model for estimation of anaplerotic substrate oxidation via acetyl-CoA.
Topics: Acetyl Coenzyme A; Animals; Aspartic Acid; Carbon Isotopes; Citric Acid Cycle; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Models, Biological; Oxaloacetates; Oxidation-Reduction; Propionates; Rats; Rats, Sprague-Dawley | 1996 |
Inhibition of the high-affinity uptake of D-[3H]aspartate in rate by L-alpha-aminoadipate and arachidonic acid.
Topics: 2-Aminoadipic Acid; Animals; Arachidonic Acid; Aspartic Acid; Biological Transport; Brain; Brain Chemistry; Carcinogens; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamate-Cysteine Ligase; Glutamic Acid; Organ Culture Techniques; Phorbol Esters; Rats; Staurosporine; Tritium | 1996 |
Identification of brain metabolites by magnetic resonance spectroscopy in MND/ALS.
Topics: Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Brain Chemistry; Creatine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy | 1996 |
Antibodies to glutamate, aspartate and glycyl-D-aspartate reversibly suppress stimulus-evoked, extracellularly recorded responses in slices of rat neocortex.
Topics: Animals; Antibodies; Aspartic Acid; Female; Glutamic Acid; Prefrontal Cortex; Rats; Synaptic Transmission | 1996 |
Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats.
Topics: Animals; Aspartic Acid; Central Nervous System Depressants; Ethanol; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Wistar; Taurine; Time Factors | 1996 |
Monitoring of asparaginase activity and asparagine levels in children on different asparaginase preparations.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Child, Preschool; Glutamic Acid; Glutamine; Humans; Infant; Infant, Newborn; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1996 |
Topiramate reduces abnormally high extracellular levels of glutamate and aspartate in the hippocampus of spontaneously epileptic rats (SER).
Topics: Animals; Anticonvulsants; Aspartic Acid; Epilepsy; Excitatory Amino Acids; Female; Fructose; Glutamic Acid; Hippocampus; Male; Microdialysis; Rats; Rats, Mutant Strains; Rats, Wistar; Topiramate | 1996 |
Release of taurine and its effects on release of neurotransmitter amino acids in rat cerebral cortex.
Topics: Animals; Aspartic Acid; Baclofen; Bicuculline; Calcium; Cerebral Cortex; Chromatography, High Pressure Liquid; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kinetics; Male; Membrane Potentials; Potassium Chloride; Rats; Rats, Wistar; Spectrometry, Fluorescence; Synaptosomes; Taurine; Time Factors | 1996 |
Broadband decoupled, 1H-localized 13C MRS of the human brain at 4 Tesla.
Topics: Aspartic Acid; Brain Chemistry; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy | 1996 |
High levels of cerebrospinal fluid glutamate in Rett syndrome.
Topics: Adolescent; Amino Acids; Aspartic Acid; Child; Child, Preschool; Female; Glutamic Acid; Humans; Infant; Rett Syndrome | 1996 |
Glutamate transport in Rhodobacter sphaeroides is mediated by a novel binding protein-dependent secondary transport system.
Topics: Aspartic Acid; Binding, Competitive; Biological Transport; Cell Membrane; Glutamic Acid; Glutamine; Ionophores; Kinetics; Mutation; Nigericin; Rhodobacter sphaeroides; Sodium; Valinomycin; Vanadates | 1996 |
A population of supramammillary area calretinin neurons terminating on medial septal area cholinergic and lateral septal area calbindin-containing cells are aspartate/glutamatergic.
Topics: Animals; Aspartic Acid; Calbindin 2; Calbindins; Choline O-Acetyltransferase; Cholinergic Fibers; Female; Glutamic Acid; Male; Mammillary Bodies; Nerve Endings; Neurons; Rats; S100 Calcium Binding Protein G; Septum Pellucidum; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 1996 |
Effect of diabetes on levels and uptake of putative amino acid neurotransmitters in rat retina and retinal pigment epithelium.
Topics: Analysis of Variance; Animals; Aspartic Acid; Diabetes Mellitus, Experimental; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Neurotransmitter Agents; Pigment Epithelium of Eye; Rats; Retina; Taurine | 1996 |
Microdialysis monitoring of variations in extracellular levels of serotonin, GABA and excitatory amino acids in the frontal cortex of awake rats in response to a single peripheral or central administration of dexfenfluramine.
Topics: Animals; Aspartic Acid; Consciousness; Dose-Response Relationship, Drug; Electrophoresis, Capillary; Excitatory Amino Acids; Extracellular Space; Fenfluramine; Fluorescent Dyes; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Lasers; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents | 1996 |
A novel mutation of presenilin 1 in familial Alzheimer's disease in Israel detected by denaturing gradient gel electrophoresis.
Topics: Alzheimer Disease; Aspartic Acid; Electrophoresis, Polyacrylamide Gel; Exons; Female; Glutamic Acid; Humans; Male; Membrane Proteins; Middle Aged; Pedigree; Presenilin-1; Seizures | 1996 |
Catalytic center quest: comparison of transposases belonging to the Tn3 family reveals an invariant triad of acidic amino acid residues.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Catalysis; Conserved Sequence; Databases, Factual; DNA Nucleotidyltransferases; DNA Transposable Elements; Evolution, Molecular; Glutamic Acid; Molecular Sequence Data; Sequence Alignment; Transposases | 1996 |
An in vivo proton magnetic resonance spectroscopy study of schizophrenia patients.
Topics: Adolescent; Adult; Antipsychotic Agents; Aspartic Acid; Chronic Disease; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 1996 |
Substrate binding mechanism of Glu180-->Gln, Asp176-->Asn, and wild-type glucoamylases from Aspergillus niger.
Topics: Asparagine; Aspartic Acid; Aspergillus niger; Glucan 1,4-alpha-Glucosidase; Glutamic Acid; Glutamine; Kinetics; Models, Chemical; Point Mutation; Protein Binding; Thermodynamics | 1996 |
Mercuric chloride uncouples glutamate uptake from the countertransport of hydroxyl equivalents.
Topics: 4-Chloromercuribenzenesulfonate; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biological Transport; Carrier Proteins; Cells, Cultured; Ethylmaleimide; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Homeostasis; Hydrogen-Ion Concentration; Hydroxides; Kinetics; Mercuric Chloride; Mice; Sulfhydryl Reagents; Symporters | 1996 |
Glutamate transport modulation of paracellular permeability across LLC-PK1-F+ monolayers.
Topics: Animals; Aspartic Acid; Cell Membrane Permeability; Epithelium; gamma-Glutamyltransferase; Glucose; Glutamic Acid; Glutamine; Isoxazoles; Kidney Tubules, Proximal; Kinetics; LLC-PK1 Cells; Models, Biological; Rabbits; Swine | 1996 |
Conservation of amino acids in multiple alignments: aspartic acid has unexpected conservation.
Topics: Amino Acid Sequence; Amino Acids; Aspartic Acid; Binding Sites; Conserved Sequence; Glutamic Acid; Glutamine; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins; Sequence Alignment | 1996 |
Neurochemical architecture of the normal and degenerating rat retina.
Topics: Amino Acids; Animals; Antibody Specificity; Arginine; Aspartic Acid; Autoradiography; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Immunohistochemistry; Nerve Degeneration; Neurotransmitter Agents; Photoreceptor Cells; Pigment Epithelium of Eye; Rats; Rats, Inbred Strains; Taurine; Tritium | 1996 |
Precipitated kappa-opioid receptor agonist withdrawal increase glutamate in rat locus coeruleus.
Topics: Analgesics; Analysis of Variance; Animals; Aspartic Acid; Benzeneacetamides; Butorphanol; Glutamic Acid; Injections, Intraventricular; Locus Coeruleus; Male; Microdialysis; Naloxone; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 1996 |
Postsynaptic glutamate uptake in rat cerebellar Purkinje cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Benzoates; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ion Channel Gating; Kynurenic Acid; Membrane Potentials; Monosaccharide Transport Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrodotoxin | 1996 |
Perturbed interaction between residues 85 and 204 in Tyr-185-->Phe and Asp-85-->Glu bacteriorhodopsins.
Topics: Aspartic Acid; Bacteriorhodopsins; Darkness; Glutamic Acid; Halobacterium; Hydrogen-Ion Concentration; Kinetics; Light; Mutagenesis, Site-Directed; Phenylalanine; Point Mutation; Recombinant Proteins; Spectrophotometry; Tyrosine | 1996 |
Effects of glutamate and aspartate on myocardial substrate oxidation during potassium arrest.
Topics: Acetoacetates; Animals; Aspartic Acid; Carbon Radioisotopes; Citric Acid Cycle; Fatty Acids; Glucose; Glutamic Acid; Heart; Heart Arrest, Induced; In Vitro Techniques; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Myocardium; Oxidation-Reduction; Oxygen Consumption; Potassium; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 1996 |
Invited editorial on "effects of glutamate and aspartate on myocardial substrate oxidation during potassium arrest".
Topics: Animals; Aspartic Acid; Citric Acid Cycle; Confounding Factors, Epidemiologic; Glutamic Acid; Heart; Heart Arrest, Induced; In Vitro Techniques; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Oxygen Consumption; Potassium; Rats; Research Design | 1996 |
Release of the excitotoxic amino acids, glutamate and aspartate, from the isolated ischemic/anoxic rat heart.
Topics: Animals; Aspartic Acid; Brain; Excitatory Amino Acids; Glutamic Acid; Hypoglycemia; Hypoxia; Male; Myocardial Ischemia; Rats | 1996 |
Profile of monoamine and excitatory amino acid release in rat supraoptic nucleus over parturition.
Topics: Animals; Aspartic Acid; Biogenic Monoamines; Dopamine; Excitatory Amino Acids; Female; Glutamic Acid; Labor, Obstetric; Microdialysis; Norepinephrine; Pregnancy; Rats; Rats, Wistar; Serotonin; Supraoptic Nucleus | 1997 |
Cerebral abnormalities in patients with cirrhosis detected by proton magnetic resonance spectroscopy and magnetic resonance imaging.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Female; Glutamic Acid; Hepatic Encephalopathy; Humans; Inositol; Liver Cirrhosis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged | 1997 |
Some considerations regarding the use of amino acid racemization in human dentine as an indicator of age at death.
Topics: Age Determination by Teeth; Amino Acids; Aspartic Acid; Calibration; Chromatography, High Pressure Liquid; Collagen; Dentin; Forensic Anthropology; Glutamic Acid; History, 19th Century; History, Ancient; History, Modern 1601-; Humans; Linear Models; Racemases and Epimerases; Serine | 1997 |
[Low-energy He-Ne-laser-induced neurochemical changes during brain ischemia/reperfusion and their integral estimation using a factor analysis model].
Topics: Adenine Nucleotides; Animals; Aspartic Acid; Brain; Brain Ischemia; Factor Analysis, Statistical; Glutamic Acid; Laser Therapy; Male; Phospholipids; Rats; Reperfusion Injury | 1996 |
The role of excitatory amino acids in hypothermic injury to mammalian spinal cord neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cell Death; Cells, Cultured; Cold Temperature; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Mice; Neurons; Receptors, N-Methyl-D-Aspartate; Reference Values; Spinal Cord; Spinal Cord Injuries | 1996 |
Cholecystokinin modulation of spontaneous and excitatory amino acid-induced activity in the opossum cerebellum.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electric Conductivity; Electrodes; Excitatory Amino Acid Antagonists; Glutamic Acid; Opossums; Purkinje Cells; Quisqualic Acid; Sincalide | 1996 |
In vivo monitoring of extracellular noradrenaline and glutamate from rat brain cortex with 2-min microdialysis sampling using capillary electrophoresis with laser-induced fluorescence detection.
Topics: Animals; Aspartic Acid; Clonidine; Electrophoresis, Capillary; Evaluation Studies as Topic; Extracellular Space; Fluorescent Dyes; Glutamic Acid; Indomethacin; Lasers; Male; Microdialysis; Microelectrodes; Norepinephrine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sympatholytics | 1996 |
Neurochemical changes in cerebellum of goldfish exposed to various temperatures.
Topics: Acclimatization; Adenine Nucleotides; Adenosine; Alanine; Animals; Aspartic Acid; Cerebellum; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Goldfish; Kinetics; Potassium; Serine; Taurine; Temperature | 1997 |
In vivo blockade of thalamic GABA(B) receptors increases excitatory amino-acid levels.
Topics: Animals; Aspartic Acid; Baclofen; GABA-B Receptor Antagonists; Glutamic Acid; Male; Microdialysis; Organophosphorus Compounds; Rats; Rats, Wistar; Receptors, GABA-B; Taurine; Thalamus | 1996 |
Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats.
Topics: Amino Acids; Animals; Aspartic Acid; Carbamazepine; Cerebellum; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Phenobarbital; Pilocarpine; Rats; Rats, Wistar; Seizures | 1997 |
Extracellular aspartate concentration increases in nucleus accumbens after cocaine sensitization.
Topics: Animals; Aspartic Acid; Behavior, Animal; Cocaine; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1997 |
Intracellular acidification of the leech giant glial cell evoked by glutamate and aspartate.
Topics: 2-Aminoadipic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acids; Animals; Antineoplastic Agents; Asparagine; Aspartic Acid; Calcium; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ganglia, Invertebrate; Glutamic Acid; Hydrogen-Ion Concentration; Kainic Acid; Leeches; Membrane Potentials; Neuroglia; Patch-Clamp Techniques; Sodium | 1997 |
Bicarbonate-sensitive cysteine induced elevation of extracellular aspartate and glutamate in rat hippocampus in vitro.
Topics: Animals; Aspartic Acid; Bicarbonates; Cysteine; Cystine; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Neurotransmitter Agents; Rats; Taurine | 1997 |
Glutamate and aspartate immunoreactivity in the reciprocal projections between the anterior thalamic nuclei and the retrosplenial granular cortex in the rat.
Topics: Animals; Aspartic Acid; Female; Glutamic Acid; Gyrus Cinguli; Immunohistochemistry; Male; Neurons; Rats; Rats, Wistar; Thalamic Nuclei; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 1997 |
Size-related properties of vestibular afferent fibers in the frog: uptake of and immunoreactivity for glycine and aspartate/glutamate.
Topics: Afferent Pathways; Animals; Aspartic Acid; Autoradiography; Brain Stem; gamma-Aminobutyric Acid; Ganglia; Glutamic Acid; Glycine; Immunohistochemistry; Injections; Nerve Fibers; Rana temporaria; Vestibular Nuclei | 1996 |
Charged amino acids near the pore entrance influence ion-conduction of a human L-type cardiac calcium channel.
Topics: Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Calcium; Calcium Channels; Electric Conductivity; Glutamic Acid; Heart; Humans; Lysine; Magnesium; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Protein Conformation; Sequence Alignment; Sequence Homology, Amino Acid; Xenopus | 1997 |
Divalent ion effects and insights into the catalytic mechanism of protein tyrosine kinase Csk.
Topics: Aspartic Acid; Catalysis; Cations, Divalent; Cobalt; Glutamic Acid; Hydrogen Bonding; Kinetics; Magnesium; Nickel; Osmolar Concentration; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src) | 1997 |
Effects of site-specific mutations on the kinetically influential ionizations of papain.
Topics: Aspartic Acid; Catalysis; Cysteine Endopeptidases; Glutamic Acid; Glycine; Kinetics; Papain; Point Mutation; Reproducibility of Results | 1997 |
AMPA receptors in cultured vestibular ganglion neurons: detection and activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Calcium; Cells, Cultured; Ganglia, Sensory; Glutamic Acid; Immunohistochemistry; Mice; Mice, Inbred CBA; Neurons; Receptors, AMPA; Vestibular Nerve | 1997 |
Substrate recognition of isocitrate dehydrogenase and 3-isopropylmalate dehydrogenase from Thermus thermophilus HB8.
Topics: 3-Isopropylmalate Dehydrogenase; Alcohol Oxidoreductases; Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Glutamic Acid; Isocitrate Dehydrogenase; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Serine; Substrate Specificity; Thermus thermophilus | 1997 |
Isolation and characterization of Rhizobium etli mutants altered in degradation of asparagine.
Topics: Asparaginase; Asparagine; Aspartate Ammonia-Lyase; Aspartic Acid; Cloning, Molecular; Enzyme Stability; Genes, Bacterial; Genetic Complementation Test; Glutamic Acid; Glutamine; Isoenzymes; Mutation; Nitrogenase; Rhizobium; Temperature | 1997 |
Calpain activation and not oxidative damage mediates L-2-chloropropionic acid-induced cerebellar granule cell necrosis.
Topics: Administration, Oral; Animals; Antioxidants; Ascorbic Acid; Aspartic Acid; Blotting, Western; Calpain; Cerebellum; Free Radicals; Glutamic Acid; Hydrocarbons, Chlorinated; Lipid Peroxidation; Male; Necrosis; Nervous System Diseases; Neurons; Oxidative Stress; Propionates; Rats; Spectrin | 1997 |
Rapid swelling of a CHO-K1 aspartate/glutamate transport mutant in hypo-osmotic medium.
Topics: 4-Chloromercuribenzenesulfonate; Adult; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Cell Size; CHO Cells; Cricetinae; Cricetulus; Erythrocytes; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Hypotonic Solutions; Osmotic Fragility; Osmotic Pressure; Symporters | 1997 |
Bepridil exacerbates glutamate-induced deterioration of calcium homeostasis and cultured nerve cell injury.
Topics: Animals; Aspartic Acid; Bepridil; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Carrier Proteins; Cell Death; Cell Survival; Cells, Cultured; Glutamic Acid; Homeostasis; Membrane Potentials; Mitochondria; Nerve Tissue; Neurons; Rats; Rats, Wistar; Sodium-Calcium Exchanger | 1996 |
Effect of glutamate-aspartate reperfusion on postischemic neonatal myocardium.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cardioplegic Solutions; Disease Models, Animal; Glucose; Glutamic Acid; Heart; Hemodynamics; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion; Rabbits; Tromethamine | 1997 |
Pharmacological characterisation of voltage-sensitive calcium channels and neurotransmitter release from mouse cerebellar granule cells in culture.
Topics: Animals; Aspartic Acid; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Female; Glutamic Acid; Ion Channel Gating; Mice; Mice, Inbred Strains; Neurons; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; omega-Conotoxins; Patch-Clamp Techniques; Peptides; Pregnancy; Spider Venoms; Tritium | 1997 |
NMR spectroscopy study of the effect of 3-nitropropionic acid on glutamate metabolism in cultured astrocytes.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Carbon Isotopes; Glutamic Acid; Lactates; Magnetic Resonance Spectroscopy; Mice; Neurotoxins; Nitro Compounds; Prefrontal Cortex; Propionates; Succinates | 1997 |
Evidence for increased cellular uptake of glutamate and aspartate in the rat hippocampus during kainic acid seizures. A microdialysis study using the "indicator diffusion' method.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Glutamic Acid; Hippocampus; Kainic Acid; Male; Microdialysis; Rats; Rats, Wistar; Seizures | 1997 |
Amino acid concentrations in hypothalamic and caudate nuclei during microwave-induced thermal stress: analysis by microdialysis.
Topics: Amino Acids; Animals; Aspartic Acid; Body Temperature; Caudate Nucleus; Chromatography, High Pressure Liquid; Electromagnetic Fields; Functional Laterality; Glutamic Acid; Glutamine; Glycine; Hot Temperature; Hypothalamus; Male; Microdialysis; Microwaves; Rats; Rats, Sprague-Dawley; Serine; Skin Temperature; Stress, Physiological; Time Factors | 1997 |
Brain injury after hypoxia-ischemia in newborn rats: relationship to extracellular levels of excitatory amino acids and cysteine.
Topics: Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Carotid Artery, Common; Cysteine; Excitatory Amino Acids; Extracellular Space; Factor Analysis, Statistical; Female; Glutamic Acid; Hypoxia, Brain; Ischemic Attack, Transient; Male; Microdialysis; Rats; Rats, Wistar; Reperfusion; Statistics, Nonparametric | 1997 |
Endothelin evokes efflux of glutamate in cultures of rat astrocytes.
Topics: Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Endothelin-1; Glutamic Acid; Ligands; Potassium; Rats; Rats, Wistar; Receptors, Endothelin; Sodium | 1997 |
Immunohistochemical studies of localization and co-localization of glutamate, aspartate and GABA in the anterior thalamic nuclei, retrosplenial granular cortex, thalamic reticular nucleus and mammillary nuclei of the rat.
Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Immunohistochemistry; Male; Mammillary Bodies; Neurons; Rats; Thalamic Nuclei | 1996 |
Transient alterations in neurotransmitter levels during a critical period of neural development in coho salmon (Oncorhyncus kisutch).
Topics: Animals; Aspartic Acid; Brain; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Neurotransmitter Agents; Oncorhynchus kisutch; Time Factors | 1996 |
Extracellular levels of glutamate and aspartate in the entopeduncular nucleus of the rat determined by microdialysis: regulation by striatal dopamine D2 receptors via the indirect striatal output pathway?
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Glutamic Acid; Hypothalamus; Male; Microdialysis; Neural Pathways; Oxidopamine; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Reserpine; Veratridine | 1997 |
Stimulated release of lactate in freely moving rats is dependent on the uptake of glutamate.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Carrier Proteins; Corpus Striatum; Dicarboxylic Acids; Extracellular Space; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Grooming; Hippocampus; Lactic Acid; Male; Microdialysis; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Symporters | 1997 |
Involvement of aspartate/glutamate antiporter in fatty acid-induced uncoupling of liver mitochondria.
Topics: Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Carrier Proteins; Diethyl Pyrocarbonate; Fatty Acids, Nonesterified; Glutamic Acid; Kinetics; Mitochondria, Liver; Oligomycins; Oxygen Consumption; Palmitic Acid; Rats; Uncoupling Agents | 1997 |
Identifying monoaminergic, GABAergic, and cholinergic characteristics in immortalized neuronal cell lines.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Aspartic Acid; Brain; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Cerebellum; Culture Media, Serum-Free; Dopamine; gamma-Aminobutyric Acid; Genes, myc; Glutamic Acid; Hippocampus; Hybrid Cells; Mice; Neuroblastoma; Neurons; Neurotransmitter Agents; Norepinephrine; PC12 Cells; Rats; Rhombencephalon; Serotonin | 1997 |
pKa measurements from nuclear magnetic resonance for the B1 and B2 immunoglobulin G-binding domains of protein G: comparison with calculated values for nuclear magnetic resonance and X-ray structures.
Topics: Aspartic Acid; Binding Sites; Crystallography, X-Ray; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Immunoglobulin G; Lysine; Magnetic Resonance Spectroscopy; Nerve Tissue Proteins; Protein Conformation; Protein Kinases; Substrate Specificity; Tyrosine | 1997 |
Regional excitatory and inhibitory amino acid concentrations in pentylenetetrazol kindling and kindled rat brain.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Convulsants; gamma-Aminobutyric Acid; Glutamic Acid; Kindling, Neurologic; Male; Neural Inhibition; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Taurine | 1997 |
Contributing mechanisms for cysteine excitotoxicity in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Bicarbonates; Biological Transport; Cell Death; Cells, Cultured; Cerebellum; Culture Media; Cysteine; Dithiothreitol; Dizocilpine Maleate; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Neurons; Neurotoxins; Rats; Rats, Wistar | 1996 |
Primary structure and functional analysis of the soluble transducer protein HtrXI in the archaeon Halobacterium salinarium.
Topics: Amino Acid Sequence; Archaeal Proteins; Aspartic Acid; Chemotaxis; Cloning, Molecular; Genes, Bacterial; Glutamic Acid; Halobacterium; Histidine; Methyltransferases; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; Sequence Deletion; Signal Transduction; Solubility; Zinc Fingers | 1997 |
Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by selective neuronal nitric oxide synthase inhibition.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Indazoles; Male; Microdialysis; Neurons; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 1997 |
Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by local nitric oxide synthase inhibition.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Microdialysis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reperfusion | 1997 |
Effect of aspartate and glutamate on nociception, catalepsy and core temperature in rats.
Topics: Adrenergic Uptake Inhibitors; Analgesia; Analgesics, Opioid; Animals; Aspartic Acid; Body Temperature; Catalepsy; Chlorpromazine; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fever; Glutamic Acid; Haloperidol; Hypothermia; Injections, Subcutaneous; Ketamine; Male; Morphine; Naloxone; Narcotic Antagonists; Nociceptors; Rats; Reserpine; Trifluoperazine | 1997 |
Cholecystokinin-8S increases dynorphin B, aspartate and glutamate release in the fronto-parietal cortex of the rat via different receptor subtypes.
Topics: Animals; Aspartic Acid; Benzodiazepinones; Devazepide; Dynorphins; Endorphins; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Hormone Antagonists; Male; Microdialysis; Neurons; Nootropic Agents; Parietal Lobe; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide | 1997 |
Temperature dependency of basal and evoked release of amino acids and calcitonin gene-related peptide from rat dorsal spinal cord.
Topics: Animals; Aspartic Acid; Body Temperature; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Chromatography, High Pressure Liquid; Cross Reactions; Fever; Glutamic Acid; Glycine; Hypothermia; Male; Organ Culture Techniques; Potassium; Rats; Rats, Sprague-Dawley; Serine; Spinal Cord; Synaptic Transmission | 1997 |
Increased CSF glutamate following injection of ALS immunoglobulins.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Glutamic Acid; Immunoglobulins; Injections, Intraperitoneal; Rats; Reference Values; Time Factors | 1997 |
Unchanged basal ganglia N-acetylaspartate and glutamate in idiopathic Parkinson's disease measured by proton magnetic resonance spectroscopy.
Topics: Aged; Apomorphine; Aspartic Acid; Basal Ganglia; Choline; Creatine; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Parkinson Disease | 1997 |
Comparative mutational analysis of peptidyl prolyl cis/trans isomerases: active sites of Escherichia coli trigger factor and human FKBP12.
Topics: Amino Acid Isomerases; Amino Acid Sequence; Aspartic Acid; Binding Sites; Carrier Proteins; Circular Dichroism; Cloning, Molecular; DNA Mutational Analysis; DNA-Binding Proteins; Glutamic Acid; Heat-Shock Proteins; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptidylprolyl Isomerase; Phenylalanine; Sequence Homology, Amino Acid; Tacrolimus Binding Proteins | 1997 |
Transporters buffer synaptically released glutamate on a submillisecond time scale.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Evoked Potentials; Glutamic Acid; Hippocampus; Kinetics; Kynurenic Acid; Lithium; Models, Neurological; Neurons; Quinoxalines; Rats; Receptors, AMPA; Synapses; Synaptic Transmission; Tetrodotoxin; Time Factors | 1997 |
Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Dementia; Discriminant Analysis; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Hydrogen; Inositol; Lactates; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Neuroglia; Neurons; Parietal Lobe; Protons; Sensitivity and Specificity; Temporal Lobe | 1997 |
A single serine residue at position 375 of VP16 is critical for complex assembly with Oct-1 and HCF and is a target of phosphorylation by casein kinase II.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Casein Kinase II; Consensus Sequence; COS Cells; DNA-Binding Proteins; Glutamic Acid; HeLa Cells; Herpes Simplex Virus Protein Vmw65; Host Cell Factor C1; Humans; Macromolecular Substances; Molecular Sequence Data; Octamer Transcription Factor-1; Phosphorylation; Protein Serine-Threonine Kinases; Serine; Threonine; Transcription Factors; Transcriptional Activation | 1997 |
Inhibition of glutamate uptake causes an acute increase in aqueous humor protein.
Topics: Alanine; Animals; Aqueous Humor; Aspartic Acid; Biological Transport; Cell Membrane Permeability; Excitatory Amino Acid Antagonists; Eye Proteins; Female; Glutamic Acid; Glutamine; Male; Rabbits | 1997 |
High levels of extracellular glutamate are present in retina during neonatal development.
Topics: Acetylcholine; Animals; Animals, Newborn; Aspartic Acid; Cellular Senescence; Glutamic Acid; Neuroglia; Neurons; Rabbits; Retina | 1996 |
Quantitative determination of glutamate turnover by 1H-observed, 13C-edited nuclear magnetic resonance spectroscopy in the cerebral cortex ex vivo: interrelationships with oxygen consumption.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Cerebral Cortex; Citric Acid Cycle; Energy Metabolism; Female; Glutamic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Oxygen Consumption; Protons; Rats; Stimulation, Chemical | 1997 |
Characterization of glutamate and [3H]D-aspartate outflow from various in vitro preparations of the rat hippocampus.
Topics: Adenosine; Animals; Aspartic Acid; Calcium; Electric Stimulation; Exocytosis; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Neurons; Potassium; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tetrodotoxin; Tritium | 1997 |
Substrate specificity of the mammary tissue anionic amino acid carrier operating in the cotransport and exchange modes.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Carrier Proteins; Epithelium; Female; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; In Vitro Techniques; Ion Transport; Mammary Glands, Animal; Perfusion; Rats; Rats, Wistar; Sodium; Substrate Specificity; Symporters | 1997 |
Glutamine utilization by rat neutrophils.
Topics: Animals; Aspartic Acid; Glutamic Acid; Glutaminase; Glutamine; In Vitro Techniques; Kinetics; Neutrophils; Rats; Rats, Wistar | 1997 |
ATP/ADP antiporter- and aspartate/glutamate antiporter-mediated fatty acid-induced uncoupling of liver mitochondria in incubation media differing in ion composition.
Topics: Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Atractyloside; Carrier Proteins; Cetrimonium; Cetrimonium Compounds; Glutamic Acid; Magnesium Chloride; Mitochondria, Liver; Mitochondrial ADP, ATP Translocases; Palmitic Acid; Potassium Chloride; Rats; Uncoupling Agents | 1997 |
Ontogeny of neurotransmitter amino acids in human fetal brains.
Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Amino Acids; Aspartic Acid; Brain; Female; gamma-Aminobutyric Acid; Gestational Age; Glutamic Acid; Glycine; Glycine Hydroxymethyltransferase; Humans; Neurotransmitter Agents; Pregnancy; Succinate-Semialdehyde Dehydrogenase; Taurine | 1997 |
Partial activation of muscle phosphorylase by replacement of serine 14 with acidic residues at the site of regulatory phosphorylation.
Topics: Animals; Aspartic Acid; Binding Sites; Enzyme Activation; Glutamic Acid; Kinetics; Muscles; Mutagenesis, Site-Directed; Phosphorylases; Phosphorylation; Phosphoserine; Protein Conformation; Protein Folding; Rabbits; Serine | 1997 |
Asp-193 and Glu-218 of subunit II are involved in the Mn2+-binding of Paracoccus denitrificans cytochrome c oxidase.
Topics: Amino Acid Sequence; Aspartic Acid; Electron Spin Resonance Spectroscopy; Electron Transport Complex IV; Glutamic Acid; Manganese; Mutagenesis, Site-Directed; Paracoccus denitrificans; Protein Binding | 1997 |
Inhibition by anion channel blockers of ischemia-evoked release of excitotoxic and other amino acids from rat cerebral cortex.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Glutamic Acid; Ion Channels; Male; Nitrobenzoates; Rats; Rats, Sprague-Dawley | 1997 |
Effects of excitatory amino acid antagonists on dendrotoxin-induced increases in neurotransmitter release and epileptiform bursting in rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; Animals; Aspartic Acid; Dizocilpine Maleate; Elapid Venoms; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Neurotoxins; Neurotransmitter Agents; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1997 |
L-2-chloropropionic acid inhibits glutamate and aspartate release from rat cerebellar slices but does not activate cerebellar NMDA receptors: implications for L-2-chloropropionic acid-induced neurotoxicity.
Topics: Animals; Aspartic Acid; Binding, Competitive; Cells, Cultured; Cerebellum; Drug Evaluation, Preclinical; Female; Glutamic Acid; Hydrocarbons, Chlorinated; In Vitro Techniques; Male; Neurotoxins; Patch-Clamp Techniques; Propionates; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate | 1997 |
Lack of involvement of glutamate-induced excitotoxicity in MPP+ toxicity in striatal dopaminergic terminals: possible involvement of ascorbate.
Topics: 1-Methyl-4-phenylpyridinium; Amino Acids, Essential; Animals; Ascorbic Acid; Aspartic Acid; Dicarboxylic Acids; Dopamine; Dopamine Agents; Extracellular Space; Glutamic Acid; Immunohistochemistry; Male; Microdialysis; MPTP Poisoning; Neostriatum; Nerve Endings; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase | 1997 |
Glutamate, aspartate and co-localization with calbindin in the medial thalamus. An immunohistochemical study in the rat.
Topics: Animals; Aspartic Acid; Calbindins; Glutamic Acid; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Nerve Tissue Proteins; Rats; Rats, Wistar; S100 Calcium Binding Protein G; Thalamic Nuclei | 1997 |
Effects of ketone bodies on astrocyte amino acid metabolism.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acids; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Citric Acid; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Hydroxybutyrates; Ketone Bodies; Rats; Rats, Sprague-Dawley; Sheep | 1997 |
In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats.
Topics: Animals; Aspartic Acid; Bridged Bicyclo Compounds; Corpus Striatum; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission; Veratridine | 1997 |
Spectrophotometric assay of D-aspartate and D-glutamate using D-aspartate oxidase with malate dehydrogenase and glutamate dehydrogenase.
Topics: Amino Acid Oxidoreductases; Aspartic Acid; D-Aspartate Oxidase; Glutamate Dehydrogenase; Glutamic Acid; Malate Dehydrogenase; Spectrophotometry | 1997 |
Effects of two hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on Ca2+ regulation of thin filament motility.
Topics: Actins; Animals; Asparagine; Aspartic Acid; Cardiomyopathy, Hypertrophic; Glutamic Acid; Glycine; Muscle, Skeletal; Mutation; Myosin Subfragments; Phalloidine; Rabbits; Rhodamines; Tropomyosin; Troponin | 1997 |
Immunocytochemical detection of amino acid neurotransmitters in paraformaldehyde-fixed tissues.
Topics: Animals; Aspartic Acid; Formaldehyde; gamma-Aminobutyric Acid; Ganglia, Spinal; Glutamic Acid; Immune Sera; Immunohistochemistry; Microtomy; Neurotransmitter Agents; Polymers; Rats; Retina; Tissue Fixation | 1997 |
Microbore liquid chromatography analysis of amino acid transmitters.
Topics: Animals; Aspartic Acid; Brain Chemistry; Chromatography, Liquid; Corpus Striatum; Electrochemistry; Fluorescence; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Microdialysis; Neurotransmitter Agents; o-Phthalaldehyde; Rats | 1997 |
Metabolite changes associated with heat shocked avian fibroblast mitochondria.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Citric Acid; Energy Metabolism; Fibroblasts; Fumarates; Glutamic Acid; Glycerophosphates; Glycolysis; Hot Temperature; Ketoglutaric Acids; Malates; Mitochondria; Phosphocreatine; Pyruvates; Stress, Physiological | 1997 |
Antidotal efficacy of glutamate and aspartate for colchicine toxicity.
Topics: Animals; Antidotes; Aspartic Acid; Body Weight; Colchicine; Female; Glutamic Acid; Gout Suppressants; Injections, Intraperitoneal; Lethal Dose 50; Mice; Poisoning; Survival Rate | 1997 |
Improved method for the measurement of glutamate and aspartate using capillary electrophoresis with laser induced fluorescence detection and its application to brain microdialysis.
Topics: Animals; Aspartic Acid; Brain Chemistry; Dentate Gyrus; Dialysis Solutions; Electrophoresis, Capillary; Glutamic Acid; Lasers; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence | 1997 |
New beta-hydroxyaspartate derivatives are competitive blockers for the bovine glutamate/aspartate transporter.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Binding, Competitive; Cattle; Glutamic Acid; Kinetics | 1997 |
The pH-dependent reciprocal changes in contributions of ADP/ATP antiporter and aspartate/glutamate antiporter to the fatty acid-induced uncoupling.
Topics: Animals; Antiporters; Aspartic Acid; Atractyloside; Fatty Acids; Glutamic Acid; Hydrogen-Ion Concentration; Magnesium Chloride; Mitochondria, Liver; Mitochondrial ADP, ATP Translocases; Oxygen Consumption; Palmitic Acid; Rats; Uncoupling Agents | 1997 |
Glutamine homologues and derivatives: a limiting factor in current artificial nutrition?
Topics: Arginine; Asparagine; Aspartic Acid; Evaluation Studies as Topic; Glutamic Acid; Glutamine; Humans; Oxaloacetates; Parenteral Nutrition, Total | 1997 |
A novel somatic mutation in the RET proto-oncogene in familial medullary thyroid carcinoma with a germline codon 768 mutation.
Topics: Aged; Amino Acid Sequence; Aspartic Acid; Base Sequence; Carcinoma, Medullary; Codon; Drosophila Proteins; Female; Glutamic Acid; Humans; Male; Middle Aged; Pedigree; Point Mutation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Thyroid Neoplasms | 1997 |
Currents evoked in Bergmann glial cells by parallel fibre stimulation in rat cerebellar slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cadmium; Cerebellum; Dicarboxylic Acids; Electric Stimulation; Evoked Potentials; Glutamic Acid; In Vitro Techniques; Male; Nerve Fibers; Neuroglia; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar; Synapses; Tetrodotoxin | 1997 |
Noncoded amino acid replacement probes of the aspartate aminotransferase mechanism.
Topics: Alanine; Amino Acids; Arginine; Aspartate Aminotransferases; Aspartic Acid; Escherichia coli; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Molecular Structure; Mutation; Protein Biosynthesis; Recombinant Proteins; Stereoisomerism; Substrate Specificity; Transcription, Genetic; Tyrosine | 1997 |
Effect of cysteinesulfinate on fatty acid-dependent uncoupling: modulation of recoupling by substrates of the aspartate/glutamate antiporter and diethyl pyrocarbonate.
Topics: Animals; Aspartic Acid; Atractyloside; Cysteine; Diethyl Pyrocarbonate; Fatty Acids; Glutamic Acid; Mitochondria, Liver; Neurotransmitter Agents; Rats | 1997 |
Negatively charged anabaena flavodoxin residues (Asp144 and Glu145) are important for reconstitution of cytochrome P450 17alpha-hydroxylase activity.
Topics: Amino Acid Sequence; Anabaena; Aspartic Acid; Cytochrome P-450 Enzyme System; Flavodoxin; Glutamic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Sequence Homology, Amino Acid; Steroid 17-alpha-Hydroxylase | 1997 |
Postsynaptic glutamate transport at the climbing fiber-Purkinje cell synapse.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Dicarboxylic Acids; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; In Vitro Techniques; Kinetics; Nerve Fibers; Oocytes; Patch-Clamp Techniques; Purkinje Cells; Pyrrolidines; Rats; Receptors, AMPA; Receptors, Glutamate; Symporters; Synapses; Synaptic Transmission; Xenopus | 1997 |
Carboxyl-directed pegylation of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biologic activity.
Topics: 3T3 Cells; Animals; Aspartic Acid; Brain-Derived Neurotrophic Factor; Cell Survival; Glutamic Acid; Male; Mice; Molecular Weight; Phosphorylation; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tissue Distribution | 1997 |
Glutamate uptake impairment and neuronal damage in young and aged rats in vivo.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dicarboxylic Acids; Glutamic Acid; Hippocampus; Kainic Acid; Kinetics; Male; Microdialysis; Nerve Degeneration; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar | 1997 |
Deletion of amino acids 1641-2437 from the foot region of skeletal muscle ryanodine receptor alters the conduction properties of the Ca release channel.
Topics: Animals; Aspartic Acid; Calcium; Calcium Channels; CHO Cells; Cloning, Molecular; Cricetinae; Glutamic Acid; Intracellular Membranes; Ion Channel Gating; Kinetics; Lipid Bilayers; Membrane Potentials; Microsomes; Muscle Proteins; Muscle, Skeletal; Mutagenesis; Probability; Rabbits; Recombinant Proteins; Ryanodine Receptor Calcium Release Channel; Sequence Deletion; Transfection | 1997 |
Evidence for a role of presynaptic AMPA receptors in the control of neuronal glutamate release in the rat forebrain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Benzothiadiazines; Binding, Competitive; Calcium; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Neurons; Presynaptic Terminals; Prosencephalon; Rats; Rats, Wistar; Receptors, AMPA; Tetrodotoxin | 1997 |
Deficits of [3H]D-aspartate binding to glutamate uptake sites in striatal and accumbens tissue in patients with schizophrenia.
Topics: Aged; Animals; Aspartic Acid; Corpus Striatum; Female; Frontal Lobe; Glutamic Acid; Humans; Male; Middle Aged; Nucleus Accumbens; Radioligand Assay; Rats; Rats, Wistar; Receptors, Glutamate; Schizophrenia; Synaptic Membranes; Tritium | 1997 |
Metabolism of acetate in rat brain neurons, astrocytes and cocultures: metabolic interactions between neurons and glia cells, monitored by NMR spectroscopy.
Topics: Acetates; Animals; Aspartic Acid; Astrocytes; Brain; Carbon Isotopes; Cells, Cultured; Coculture Techniques; Glial Fibrillary Acidic Protein; Glutamic Acid; Glutamine; Immunoblotting; Magnetic Resonance Spectroscopy; Neuroglia; Neurons; Phosphorus Isotopes; Rats; Rats, Wistar; Tritium | 1997 |
Glutamate transport and metabolism in astrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Biological Transport; Cells, Cultured; Energy Metabolism; Glucose; Glutamic Acid; Glycogen; Glycolysis; Homeostasis; Lactates; Mice; Models, Neurological; Neurons; Prefrontal Cortex | 1997 |
Correlation between cortical EEG and striatal microdialysis in soman-intoxicated rats.
Topics: Animals; Aspartic Acid; Cholinesterase Inhibitors; Corpus Striatum; Dopamine; Electroencephalography; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Rats; Rats, Wistar; Soman | 1997 |
Evidence for the involvement of endogenous aspartate in the mediation of carotid chemoreceptor reflexes in the rostral ventrolateral medulla of the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Blood Pressure; Carotid Body; Chemoreceptor Cells; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Medulla Oblongata; Microinjections; Phenylephrine; Potassium; Rats; Rats, Wistar; Reflex; Stereotaxic Techniques | 1997 |
Role of glutamate and aspartate in epileptogenesis; contribution of microdialysis studies in animal and man.
Topics: Animals; Aspartic Acid; Brain; Brain Mapping; Electroencephalography; Epilepsies, Partial; Epilepsy; Evoked Potentials; Glutamic Acid; Humans; Microdialysis; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1996 |
Evidence for collateral projections to the retrosplenial granular cortex and thalamic reticular nucleus from glutamate and/or aspartate-containing neurons of the anterior thalamic nuclei in the rat.
Topics: Amidines; Animals; Aspartic Acid; Axons; Benzofurans; Cerebral Cortex; Fluorescent Dyes; Glutamic Acid; Immunohistochemistry; Injections; Neurons; Rats; Rats, Wistar; Stereotaxic Techniques; Thalamic Nuclei | 1997 |
Aspartate 19 and glutamate 121 are critical for transport function of the myo-inositol/H+ symporter from Leishmania donovani.
Topics: Animals; Aspartic Acid; Carrier Proteins; Cell Membrane; Glutamic Acid; Hydrogen; Hydrogen-Ion Concentration; Inositol; Leishmania donovani; Mutagenesis, Site-Directed; Oocytes; Protein Structure, Secondary; Recombinant Proteins; Xenopus laevis | 1997 |
Effects of electroacupuncture on extracellular contents of amino acid neurotransmitters in rat striatum following transient focal cerebral ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Infarction; Chromatography, High Pressure Liquid; Corpus Striatum; Electroacupuncture; Excitatory Amino Acids; Fluorescence; Glutamic Acid; Male; Microdialysis; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Taurine | 1997 |
Measurement of glutamate and glutamine in the medial prefrontal cortex of never-treated schizophrenic patients and healthy controls by proton magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Aspartic Acid; Educational Status; Female; Functional Laterality; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Prefrontal Cortex; Protons; Schizophrenia; Sex Factors; Tomography, Emission-Computed | 1997 |
Evidence for founder effect of the Glu104Asp substitution and identification of new mutations in triosephosphate isomerase deficiency.
Topics: Anemia, Hemolytic, Congenital Nonspherocytic; Aspartic Acid; Deoxyribonucleases, Type II Site-Specific; Europe; Female; Founder Effect; Glutamic Acid; Haplotypes; Humans; Male; Mutation; Pedigree; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Restriction Mapping; Triose-Phosphate Isomerase | 1997 |
The roles of conserved carboxylate residues in IMP dehydrogenase and identification of a transition state analog.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Carboxylic Acids; Conserved Sequence; Cross-Linking Reagents; Enzyme Activation; Escherichia coli; Ethyldimethylaminopropyl Carbodiimide; Glutamic Acid; Humans; IMP Dehydrogenase; Mutagenesis, Site-Directed; Protein Conformation; Ribonucleosides | 1997 |
Ultrastructural localization of neurotransmitter immunoreactivity in mossy cell axons and their synaptic targets in the rat dentate gyrus.
Topics: Animals; Aspartic Acid; Axons; Dentate Gyrus; Female; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Microscopy, Electron; Mossy Fibers, Hippocampal; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Synapses | 1997 |
Erythrocyte and plasma levels of glutamate and aspartate in children affected by migraine.
Topics: Analysis of Variance; Aspartic Acid; Case-Control Studies; Child; Erythrocytes; Female; Glutamic Acid; Humans; Male; Migraine Disorders | 1997 |
Evaluation of the role of specific acidic amino acid residues in electron transfer between the flavodoxin and cytochrome c3 from Desulfovibrio vulgaris.
Topics: Amino Acids, Dicarboxylic; Asparagine; Aspartic Acid; Cytochrome c Group; Desulfovibrio vulgaris; Electrochemistry; Electron Transport; Flavodoxin; Gene Expression Regulation, Bacterial; Glutamic Acid; Glutamine; Models, Molecular; Mutagenesis, Site-Directed; Osmolar Concentration | 1997 |
Manganese decreases glutamate uptake in cultured astrocytes.
Topics: Adenosine Triphosphate; Ammonia; Animals; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; Drug Combinations; Glutamic Acid; Kinetics; Manganese; Rats; Sucrose | 1997 |
M1 muscarinic receptor stimulation decreases aspartate release in the rat neostriatum.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Arecoline; Aspartic Acid; Chemotherapy, Cancer, Regional Perfusion; Extracellular Space; Glutamic Acid; Injections, Intraperitoneal; Male; Neostriatum; Oxotremorine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, Muscarinic | 1997 |
The purified and reconstituted ornithine/citrulline carrier from rat liver mitochondria: electrical nature and coupling of the exchange reaction with H+ translocation.
Topics: Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Carrier Proteins; Cations, Monovalent; Citrulline; Glutamic Acid; Hydrogen-Ion Concentration; Intracellular Membranes; Kinetics; Membrane Potentials; Mitochondria, Liver; Mitochondrial ADP, ATP Translocases; Nigericin; Ornithine; Rats | 1997 |
Intracerebral microdialysis study of glutamate reuptake in awake, behaving rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anti-Bacterial Agents; Aspartic Acid; Behavior, Animal; Carbon Radioisotopes; Consciousness; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Mannitol; Microdialysis; Norepinephrine; Parietal Lobe; Phentolamine; Phenylephrine; Rats; Rats, Sprague-Dawley; Sympatholytics; Sympathomimetics; Synaptic Transmission; Tritium | 1997 |
Proton and electron transfer to the secondary quinone (QB) in bacterial reaction centers: the effect of changing the electrostatics in the vicinity of QB by interchanging asp and glu at the L212 and L213 sites.
Topics: Aspartic Acid; Electron Transport; Glutamic Acid; Hydrogen-Ion Concentration; Models, Chemical; Mutagenesis, Site-Directed; Photosynthesis; Photosynthetic Reaction Center Complex Proteins; Protons; Rhodobacter sphaeroides; Static Electricity; Subcellular Fractions; Thermodynamics; Ubiquinone | 1997 |
Glutamate residues located within putative transmembrane helices are essential for TetA(P)-mediated tetracycline efflux.
Topics: Antiporters; Aspartic Acid; Bacterial Proteins; Biological Transport; Cell Membrane; Escherichia coli; Glucose; Glutamic Acid; Glutamine; Immunoblotting; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Plasmids; RNA, Bacterial; Tetracycline; Tetracycline Resistance | 1997 |
High temporal resolution monitoring of glutamate and aspartate in vivo using microdialysis on-line with capillary electrophoresis with laser-induced fluorescence detection.
Topics: Animals; Aspartic Acid; Electrophoresis, Capillary; Glutamic Acid; Lasers; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence | 1997 |
Functional role of aspartyl and glutamyl residues in the membrane segments of the yeast PMA1 ATPase: interaction with DCCD.
Topics: Aspartic Acid; Cell Membrane; Dicyclohexylcarbodiimide; Fungal Proteins; Glutamic Acid; Mutagenesis, Site-Directed; Proton-Translocating ATPases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Structure-Activity Relationship; Uncoupling Agents | 1997 |
AMPA receptor-mediated slow neuronal death in the rat spinal cord induced by long-term blockade of glutamate transporters with THA.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Cell Death; Glutamic Acid; Hindlimb; Infusions, Parenteral; Injections, Spinal; Male; Motor Activity; Neurons; Paralysis; Rats; Rats, Wistar; Receptors, AMPA; Spinal Cord; Subarachnoid Space; Tail; Time Factors; Urinary Incontinence | 1997 |
Capillary electrophoresis of glutamate and aspartate in rat brain dialysate. Improvements in detection and analysis time using cyclodextrins.
Topics: Animals; Aspartic Acid; Buffers; Corpus Striatum; Cyclodextrins; Dialysis Solutions; Electrophoresis, Capillary; Glutamic Acid; Microdialysis; Rats; Sensitivity and Specificity; Spectrometry, Fluorescence; Time Factors | 1997 |
Glutamate and aspartate as proton shuttles in mutants of carbonic anhydrase.
Topics: Animals; Aspartic Acid; Carbon Dioxide; Carbonic Anhydrases; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Mice; Mutagenesis, Site-Directed; Protons; Recombinant Proteins; Spectrophotometry; Zinc | 1997 |
Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Aspartic Acid; Butylated Hydroxytoluene; Cells, Cultured; Cerebellar Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Free Radical Scavengers; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Piperidines; Putrescine; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Vitamin E | 1997 |
Regulation of D-aspartate release and uptake in adult brain stem auditory nuclei after unilateral middle ear ossicle removal and cochlear ablation.
Topics: Animals; Aspartic Acid; Auditory Pathways; Cochlea; Cochlear Nucleus; Ear Ossicles; Female; Glutamic Acid; Guinea Pigs; Hearing Loss, Conductive; Hearing Loss, Sensorineural; Hyperacusis; Male; Nerve Fibers; Neuronal Plasticity; Olivary Nucleus; Retrograde Degeneration; Synaptic Transmission; Tinnitus | 1997 |
The role of striatal glutamatergic system in haloperidol-induced dopamine receptor supersensitivity and effects of monosialoganglioside GM1.
Topics: Animals; Aspartic Acid; Dopamine Antagonists; G(M1) Ganglioside; Glutamic Acid; Haloperidol; Male; Neostriatum; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Glutamate; Spiperone | 1997 |
Arachidonic acid inhibits uptake of amino acids and potentiates PKC effects on glutamate, but not GABA, exocytosis in isolated hippocampal nerve terminals.
Topics: 4-Aminopyridine; Adenosine Diphosphate; Adenosine Triphosphate; Amino Acids; Animals; Arachidonic Acid; Aspartic Acid; Biological Transport; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Indomethacin; Kinetics; L-Lactate Dehydrogenase; Male; Masoprocol; Nerve Endings; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Wistar; Sodium; Synaptosomes | 1997 |
Spinal cord stimulation attenuates augmented dorsal horn release of excitatory amino acids in mononeuropathy via a GABAergic mechanism.
Topics: Animals; Aspartic Acid; Electric Stimulation; Excitatory Amino Acids; GABA Agents; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Sciatic Nerve; Spinal Cord | 1997 |
The penumbra zone of a traumatic cortical lesion: a microdialysis study of excitatory amino acid release.
Topics: Animals; Aspartic Acid; Brain Injuries; Excitatory Amino Acids; Glutamic Acid; Male; Microdialysis; Necrosis; Rats; Rats, Sprague-Dawley | 1997 |
The 2D NMR experiments H(C)CO2 and HCCO2 for assignment and pH titration of carboxylate groups in uniformly 15N/13C-labeled proteins.
Topics: Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Glutamic Acid; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Proteins | 1997 |
Postsynaptic response kinetics are controlled by a glutamate transporter at cone photoreceptors.
Topics: Ambystoma; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Calcium; Darkness; Glutamic Acid; Kainic Acid; Kinetics; Light; Magnesium; Membrane Potentials; Patch-Clamp Techniques; Retina; Retinal Cone Photoreceptor Cells; Synapses; Synaptic Transmission | 1998 |
GM-CSF affects hypothalamic neurotransmitter levels in mice: involvement of interleukin-1.
Topics: Animals; Aspartic Acid; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hypothalamus; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Male; Mice; Neurotransmitter Agents; Norepinephrine; Receptors, Interleukin-1; Recombinant Proteins; Serotonin; Sialoglycoproteins | 1997 |
In vitro simulation of thermotherapy for benign prostatic hyperplasia by Fourier transform infrared microspectroscopy combined with differential scanning calorimetry.
Topics: Amides; Aspartic Acid; Calorimetry, Differential Scanning; Epithelium; Glutamic Acid; Humans; Hyperthermia, Induced; Male; Prostatic Hyperplasia; Protein Denaturation; Proteins; Spectroscopy, Fourier Transform Infrared; Stromal Cells | 1997 |
A high affinity glutamate/aspartate transport system in pancreatic islets of Langerhans modulates glucose-stimulated insulin secretion.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Cells, Cultured; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Rats | 1998 |
Insight into signal transduction: structural alterations in transmembrane helices probed by multi-1 ns molecular dynamics simulations.
Topics: Amino Acid Sequence; Aspartic Acid; Computer Simulation; Glutamic Acid; Glutamine; Glycine; Models, Molecular; Molecular Sequence Data; Mutagenesis; Peptides; Protein Conformation; Receptor, ErbB-2; Signal Transduction | 1997 |
Do the integrases of LTR-retrotransposons and class II element transposases have a common ancestor?
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Conserved Sequence; Evolution, Molecular; Glutamic Acid; Humans; Integrases; Molecular Sequence Data; Protein Structure, Tertiary; Repetitive Sequences, Nucleic Acid; Retroelements; Sequence Homology, Amino Acid; Transposases | 1997 |
Nitric oxide synthase-, N-methyl-D-aspartate receptor-, glutamate- and aspartate-immunoreactive neurons in the mouse arcuate nucleus: effects of neonatal treatment with monosodium glutamate.
Topics: Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; Aspartic Acid; Fluorescent Dyes; Glutamic Acid; Immunohistochemistry; Male; Mice; Neurons; Nitric Oxide Synthase; Oxazines; Receptors, N-Methyl-D-Aspartate; Sodium Glutamate | 1997 |
Clozapine treatment increases serum glutamate and aspartate compared to conventional neuroleptics.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Clozapine; Female; Glutamic Acid; Humans; Linear Models; Male; Middle Aged; Schizophrenia | 1997 |
Evidence for neuronal origin and metabotropic receptor-mediated regulation of extracellular glutamate and aspartate in rat striatum in vivo following electrical stimulation of the prefrontal cortex.
Topics: Animals; Aspartic Acid; Benzoates; Calcium; Corpus Striatum; Cycloleucine; Dicarboxylic Acids; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Glycine; Male; Neurons; Neurotransmitter Uptake Inhibitors; Prefrontal Cortex; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tetrodotoxin; Time Factors | 1998 |
Exocytotic and nonexocytotic modes of glutamate release from cultured cerebellar granule cells during chemical ischaemia.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Aspartic Acid; Brain Ischemia; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Cytoplasm; Deoxyglucose; Dizocilpine Maleate; Exocytosis; Fluorescent Dyes; Glutamic Acid; Macrolides; Neurons; omega-Conotoxins; Peptides; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Cyanide; Tetanus Toxin; Time Factors | 1998 |
Effect of Asp-97-->Glu substitution on the pH dependence of catalysis by inorganic pyrophosphatase of Escherichia coli.
Topics: Amino Acid Substitution; Aspartic Acid; Catalysis; Escherichia coli; Glutamic Acid; Hydrogen-Ion Concentration; Inorganic Pyrophosphatase; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Pyrophosphatases | 1997 |
Increase of the intracellular Ca2+ concentration mediated by transport of glutamate into rat hippocampal synaptosomes: characterization of the activated voltage sensitive Ca2+ channels.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Glutamic Acid; Hippocampus; Kainic Acid; Male; omega-Agatoxin IVA; omega-Conotoxin GVIA; omega-Conotoxins; Peptides; Rats; Rats, Wistar; Receptors, Glutamate; Spider Venoms; Synaptosomes | 1998 |
In vivo microdialysis reveals facilitatory metabotropic glutamate receptors regulating excitatory amino acid release in rat nucleus tractus solitarius.
Topics: Animals; Aspartic Acid; Benzoates; Calcium; Chromatography, High Pressure Liquid; Cycloleucine; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Glycine; Kinetics; Male; Microdialysis; Neurotoxins; Rats; Rats, Inbred WKY; Receptors, Metabotropic Glutamate; Solitary Nucleus; Tetrodotoxin | 1998 |
Aspartate as a selective NMDA receptor agonist in cultured cells from the avian retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Retina | 1998 |
Neurotransmitters in cerebrospinal fluid reflect pathological activity.
Topics: Adult; Aged; Asparagine; Aspartic Acid; Blood-Brain Barrier; Central Nervous System Diseases; Female; Glutamic Acid; Glutamine; Glycine; Humans; L-Lactate Dehydrogenase; Male; Middle Aged; Neurotransmitter Agents; Serine; Taurine | 1997 |
Calcium-binding protein immunoreactivity in the piriform cortex of the guinea-pig: selective staining of subsets of non-GABAergic neurons by calretinin.
Topics: Animals; Aspartic Acid; Calbindin 2; Calcium-Binding Proteins; Cerebral Cortex; Coloring Agents; Glutamic Acid; Guinea Pigs; Immunohistochemistry; Nerve Tissue Proteins; Neurons; Receptors, Glutamate; S100 Calcium Binding Protein G | 1998 |
Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria.
Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Female; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Malaria; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Osmolar Concentration; Oxidation-Reduction; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1998 |
[Conformational states of cyclic dipeptides with lactam bond between omega-functions of lysine and aspartic or glutamic acid residues].
Topics: Aspartic Acid; Circular Dichroism; Computer Simulation; Dipeptides; Glutamic Acid; Lactams; Lysine; Magnetic Resonance Spectroscopy; Peptides, Cyclic; Protein Conformation | 1997 |
Activation of NMDA and non-NMDA receptors by L-aspartate in the suprachiasmatic nucleus of the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Excitatory Amino Acid Agonists; Female; Glutamic Acid; In Vitro Techniques; Male; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Suprachiasmatic Nucleus | 1998 |
Influence of excision of a methylene group from Glu-376 (Glu376-->Asp mutation) in the medium chain acyl-CoA dehydrogenase-catalyzed reaction.
Topics: Acyl Coenzyme A; Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Animals; Aspartic Acid; Catalysis; Enzyme Activation; Glutamic Acid; Humans; Hydrocarbons; Kinetics; Liver; Methane; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Swine | 1998 |
Glu-320 and Asp-323 are determinants of the CYP4A1 hydroxylation regiospecificity and resistance to inactivation by 1-aminobenzotriazole.
Topics: Amino Acid Substitution; Aspartic Acid; Binding Sites; Catalysis; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Enzyme Activation; Glutamic Acid; Humans; Hydroxylation; Imidazoles; Imines; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Recombinant Proteins; Substrate Specificity; Triazoles | 1998 |
Importance of intramembrane carboxylic acids for occlusion of K+ ions at equilibrium in renal Na,K-ATPase.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Carboxylic Acids; Glutamic Acid; Intracellular Membranes; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Potassium Channels; Recombinant Proteins; Rubidium; Saccharomyces cerevisiae; Sodium-Potassium-Exchanging ATPase; Swine; Thallium | 1998 |
Gluconeogenesis measured with [U-13C]glucose and mass isotopomer analysis of apoB-100 amino acids in pigs.
Topics: Alanine; Animals; Apolipoprotein B-100; Apolipoproteins B; Aspartic Acid; Blood Glucose; Carbon Isotopes; Female; Gluconeogenesis; Glucose; Glutamic Acid; Indicator Dilution Techniques; Isotope Labeling; Liver; Mass Spectrometry; Models, Biological; Oxaloacetates; Pyruvate Dehydrogenase Complex; Swine | 1998 |
Changes in excitatory amino acid levels and tissue energy metabolites of neonate rat brain after hypoxia and hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Ischemia; Energy Metabolism; Excitatory Amino Acids; Glutamic Acid; Hypoxanthine; Hypoxia; Malondialdehyde; Rats; Rats, Wistar; Xanthine | 1998 |
Modulation of human glutamate transporter activity by phorbol ester.
Topics: Amino Acid Transport System X-AG; Anti-Bacterial Agents; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Carcinogens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamates; Glutamic Acid; Humans; Kainic Acid; Kinetics; Phorbol Esters; Protein Kinase C; Retinoblastoma; Staurosporine; Tumor Cells, Cultured | 1998 |
Alpha-ketoisocaproate alters the production of both lactate and aspartate from [U-13C]glutamate in astrocytes: a 13C NMR study.
Topics: Amino Acids, Branched-Chain; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Caproates; Carbon Isotopes; Culture Media; Glutamic Acid; Keto Acids; Lactic Acid; Magnetic Resonance Spectroscopy; Perchlorates; Rats | 1998 |
Aspartic and glutamic acids increase in the frontal cortex during prostaglandin E1 hyperthermia.
Topics: Adipose Tissue, Brown; Alprostadil; Animals; Aspartic Acid; Body Temperature Regulation; Colon; Fever; Frontal Lobe; Glutamic Acid; Injections, Intraventricular; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System | 1998 |
Tamoxifen, a chloride channel blocker, reduces glutamate and aspartate release from the ischemic cerebral cortex.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Chloride Channels; Estrogen Antagonists; Glutamic Acid; Ischemic Attack, Transient; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Tamoxifen | 1998 |
[U-13C]glutamate metabolism in astrocytes during hypoglycemia and hypoxia.
Topics: Animals; Aspartic Acid; Astrocytes; Carbon Isotopes; Cell Hypoxia; Cells, Cultured; Glucose; Glutamic Acid; Glycolysis; Hypoglycemia; Iodoacetates; Iodoacetic Acid; Lactic Acid; Magnetic Resonance Spectroscopy; Mice; Prefrontal Cortex; Proline | 1998 |
A conserved histidine is essential for glycerolipid acyltransferase catalysis.
Topics: Acyltransferases; Alanine; Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Cell Membrane; Cloning, Molecular; DNA, Bacterial; Escherichia coli; Gene Expression; Genetic Complementation Test; Glutamic Acid; Glycerol-3-Phosphate O-Acyltransferase; Histidine; Molecular Sequence Data; Plasmids; Polymerase Chain Reaction; Protein Biosynthesis; Sequence Alignment; Sequence Analysis, DNA; Transcription, Genetic | 1998 |
Formalin-induced release of excitatory amino acids in the skin of the rat hindpaw.
Topics: Animals; Aspartic Acid; Formaldehyde; Glutamic Acid; Hindlimb; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Skin | 1998 |
Lysine and arginine residues in the N-terminal 18% of apolipoprotein B are critical for its binding to microsomal triglyceride transfer protein.
Topics: Apolipoproteins B; Arginine; Aspartic Acid; Binding Sites; Carrier Proteins; Cell Line; Glutamic Acid; Heparin; Histidine; Humans; Lysine; Microsomes; Protein Binding; Receptors, LDL | 1998 |
Positron emission tomography analysis of [1-(11)C] acetate kinetics in short-term hibernating myocardium.
Topics: Acetates; Animals; Aspartic Acid; Carbon Radioisotopes; Glutamic Acid; Myocardial Ischemia; Myocardial Stunning; Swine; Swine, Miniature; Tomography, Emission-Computed; Tricarboxylic Acids | 1998 |
Site-directed mutagenesis of conserved aspartates, glutamates and arginines in the active site region of Escherichia coli DNA topoisomerase I.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Aspartic Acid; Binding Sites; DNA Primers; DNA Topoisomerases, Type I; Escherichia coli; Glutamic Acid; Kinetics; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Spectrometry, Fluorescence | 1998 |
Role of glutamate receptors and voltage-dependent calcium and sodium channels in the extracellular glutamate/aspartate accumulation and subsequent neuronal injury induced by oxygen/glucose deprivation in cultured hippocampal neurons.
Topics: Animals; Aspartic Acid; Calcium Channel Blockers; Cell Hypoxia; Cells, Cultured; Excitatory Amino Acid Agonists; Glucose; Glutamic Acid; Hippocampus; Ischemia; L-Lactate Dehydrogenase; Neurons; Oxygen; Rats; Rats, Wistar; Receptors, Glutamate; Sodium Channel Agonists; Sodium Channels | 1998 |
Simultaneous determination of total and extracellular concentrations of the amino acid neurotransmitters in cat visual cortex by microbore liquid chromatography and electrochemical detection.
Topics: Animals; Aspartic Acid; Cats; Chromatography, High Pressure Liquid; Electrochemistry; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hydrogen-Ion Concentration; Microdialysis; Neurotransmitter Agents; o-Phthalaldehyde; Sulfhydryl Compounds; Taurine; Visual Cortex | 1998 |
The neurochemical markers in cerebrospinal fluid to differentiate between aseptic and tuberculous meningitis.
Topics: Adult; Amino Acids; Aspartic Acid; Biomarkers; Diagnosis, Differential; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Homocysteine; Humans; Male; Meningitis, Aseptic; Middle Aged; Nitrites; Tryptophan; Tuberculosis, Meningeal; Vitamin B 12 | 1998 |
A ligand-mimetic model for constitutive activation of the melanocortin-1 receptor.
Topics: Alleles; Amino Acid Sequence; Animals; Aspartic Acid; Cattle; Conserved Sequence; Foxes; Genes, Dominant; Glutamic Acid; Hair Color; Histidine; Ligands; Lysine; Mice; Models, Genetic; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Proline; Receptors, Corticotropin; Receptors, Melanocortin; Sheep | 1998 |
General base catalysis by the phosphatidylcholine-preferring phospholipase C from Bacillus cereus: the role of Glu4 and Asp55.
Topics: Aspartic Acid; Bacillus cereus; Catalysis; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Ligands; Mutagenesis, Site-Directed; Phosphatidylcholines; Substrate Specificity; Type C Phospholipases; Zinc | 1998 |
[From the study of biochemical changes in ischemic and reperfused skeletal muscle to the controlled reperfusion of limbs in patients with acute severe ischemia].
Topics: Acute Disease; Aged; Aged, 80 and over; Alkalies; Aspartic Acid; Biochemical Phenomena; Biochemistry; Calcium; Catheterization; Crystalloid Solutions; Embolectomy; Embolism; Female; Femoral Artery; Glutamic Acid; Humans; Infusions, Intra-Arterial; Ischemia; Isotonic Solutions; Leg; Movement; Muscle, Skeletal; Osmolar Concentration; Plasma Substitutes; Pressure; Rehydration Solutions; Reperfusion; Rheology; Sensation; Temperature | 1998 |
Release of endogenous glutamate, aspartate, GABA, and taurine from hippocampal slices from adult and developing mice under cell-damaging conditions.
Topics: Aging; Animals; Aspartic Acid; Brain Ischemia; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Hypoxia; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Potassium; Taurine | 1998 |
Proton MR spectroscopy in Lesch-Nyhan disease.
Topics: Adolescent; Adult; Aspartic Acid; Child; Choline; Corpus Striatum; Glutamic Acid; Glutamine; Humans; Inositol; Lesch-Nyhan Syndrome; Magnetic Resonance Spectroscopy; Male; Prefrontal Cortex; Protons | 1998 |
Catalytic contribution of phenylalanine-101 of 3-oxo-Delta 5-steroid isomerase.
Topics: Alanine; Aspartic Acid; Catalysis; Energy Transfer; Glutamic Acid; Hydrogen-Ion Concentration; Leucine; Mutagenesis, Insertional; Phenylalanine; Pseudomonas; Steroid Isomerases | 1998 |
Characterization of D10S and K71E mutants of human cytosolic hsp70.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aspartic Acid; Clathrin; Cytochrome c Group; Cytosol; Glutamic Acid; Heat-Shock Proteins; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Lysine; Mutagenesis, Insertional; Nucleotides; Peptides; Recombinant Proteins; Serine | 1998 |
Involvement of glutamic acid 278 in the redox reaction of the cytochrome c oxidase from Paracoccus denitrificans investigated by FTIR spectroscopy.
Topics: Asparagine; Aspartic Acid; Deuterium Oxide; Electron Transport Complex IV; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Oxidation-Reduction; Paracoccus denitrificans; Serine; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared | 1998 |
Circadian release of amino acids in the suprachiasmatic nucleus in vitro.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Circadian Rhythm; Culture Media; Glutamic Acid; Glycine; Immunoenzyme Techniques; Organ Culture Techniques; Rats; Suprachiasmatic Nucleus | 1998 |
Intravenous aspartate infusion after a coronary operation: effects on myocardial metabolism and hemodynamic state.
Topics: Alanine; Angina Pectoris; Aspartic Acid; Blood Glucose; Cardiac Catheterization; Coronary Artery Bypass; Fatty Acids, Nonesterified; Glucose; Glutamic Acid; Heart; Heart Arrest, Induced; Heart Rate; Hemodynamics; Humans; Infusions, Intravenous; Lactates; Lung; Male; Middle Aged; Myocardium; Oxygen; Oxygen Consumption; Vascular Resistance | 1998 |
Preferential blockade of cholecystokinin-8S-induced increases in aspartate and glutamate levels by the CCK(B) receptor antagonist, L-365,260, in rat brain.
Topics: Animals; Aspartic Acid; Benzodiazepinones; Brain; Glutamic Acid; Male; Microdialysis; Phenylurea Compounds; Rats; Rats, Wistar; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Sincalide | 1998 |
Changes in brain organic osmolytes in experimental cerebral ischemia.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Creatine; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycerylphosphorylcholine; Magnetic Resonance Spectroscopy; Male; Methylamines; Phosphocreatine; Rats; Rats, Sprague-Dawley; Taurine | 1998 |
Structural selectivity and molecular nature of L-glutamate transport in cultured human fibroblasts.
Topics: Amino Acid Transport System X-AG; Antibodies; Aspartic Acid; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport; Carrier Proteins; Cells, Cultured; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Fibroblasts; Flow Cytometry; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Isomerism; Models, Chemical; Models, Molecular; Receptors, Glutamate; Receptors, Neurotransmitter; Skin; Symporters | 1998 |
New approach for quantitation of short echo time in vivo 1H MR spectra of brain using AMARES.
Topics: Algorithms; Animals; Aspartic Acid; Brain; Choline; Creatine; Dipeptides; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Magnetic Resonance Imaging; Male; Rats; Rats, Wistar; Software; Time Factors | 1998 |
Sulfhydryl oxidation of mutants with cysteine in place of acidic residues in the lactose permease.
Topics: Amino Acid Substitution; Aspartic Acid; Cysteine; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Membrane Transport Proteins; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Oxidation-Reduction; Structure-Activity Relationship; Sulfhydryl Compounds; Sulfinic Acids; Sulfonic Acids; Symporters | 1998 |
Effect of precipitated withdrawal on extracellular glutamate and aspartate in the nucleus accumbens of chronically morphine-treated rats: an in vivo microdialysis study.
Topics: Animals; Aspartic Acid; Calcium; Extracellular Space; Glutamic Acid; Male; Microdialysis; Morphine; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1998 |
Glutamate transport and cellular glutamine metabolism: regulation in LLC-PK1 vs. LLC-PK1-F+ cell lines.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Binding, Competitive; Biological Transport; gamma-Glutamyltransferase; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Homeostasis; Ketoglutaric Acids; Kinetics; LLC-PK1 Cells; Quaternary Ammonium Compounds; Swine | 1998 |
Polymerization on the rocks: negatively-charged alpha-amino acids.
Topics: Adsorption; Amino Acids, Dicarboxylic; Aspartic Acid; Chromatography, High Pressure Liquid; Durapatite; Electrochemistry; Glutamic Acid; Minerals; Models, Chemical; Oligopeptides; Peptides; Phosphoserine | 1998 |
Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2.
Topics: Amino Acid Sequence; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Gene Expression; Glutamates; Glutamic Acid; Humans; Kainic Acid; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Receptors, Neurotransmitter; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Alignment; Serine; Xenopus laevis | 1998 |
Action of excitatory amino acids on hypodermis and the motornervous system of Ascaris suum: pharmacological evidence for a glutamate transporter.
Topics: Amino Acid Transport System X-AG; Animals; Ascaris suum; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport, Active; Calcium; Dose-Response Relationship, Drug; Electric Conductivity; Epithelium; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Membrane Potentials; Microelectrodes; Motor Neurons; Quinoxalines; Sodium | 1998 |
Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Aspartic Acid; Crystallography, X-Ray; Glutamic Acid; Hydrogen-Ion Concentration; Macromolecular Substances; Mice; Models, Molecular; Pentostatin; Protein Conformation; Purine Nucleosides; Ribonucleosides; Substrate Specificity; Zinc | 1998 |
Discriminatory influence of Glu-376-->Asp mutation in medium-chain acyl-CoA dehydrogenase on the binding of selected CoA-ligands: spectroscopic, thermodynamic, kinetic, and model building studies.
Topics: Acyl Coenzyme A; Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Animals; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Glutamic Acid; Kinetics; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Spectrophotometry; Swine; Thermodynamics | 1998 |
Intraventricular injection of human immunodeficiency virus type 1 (HIV-1) tat protein causes inflammation, gliosis, apoptosis, and ventricular enlargement.
Topics: Animals; Apoptosis; Aspartic Acid; Astrocytes; Basal Ganglia; Biotin; Cerebral Cortex; Cerebral Ventricles; Encephalitis, Viral; Ependyma; gamma-Aminobutyric Acid; Gene Products, tat; Gliosis; Glutamic Acid; Hippocampus; HIV-1; Humans; Injections, Intraventricular; Magnetic Resonance Spectroscopy; Male; Neutrophils; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Staining and Labeling; tat Gene Products, Human Immunodeficiency Virus | 1998 |
Involvement of aspartate/glutamate antiporter in uncoupling effect of fatty acids in heart mitochondria.
Topics: Animals; Antiporters; Aspartic Acid; Atractyloside; Diethyl Pyrocarbonate; Fatty Acids; Glutamic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Lauric Acids; Membrane Potentials; Mitochondria, Heart; Oxygen Consumption; Rats; Uncoupling Agents | 1998 |
Cell-damaging conditions release more taurine than excitatory amino acids from the immature hippocampus.
Topics: Animals; Aspartic Acid; Calcium; Culture Media; Glutamic Acid; Hippocampus; Mice; Neurons; Potassium; Taurine | 1998 |
Properties of intramolecular proton transfer in carbonic anhydrase III.
Topics: Amino Acid Substitution; Aspartic Acid; Calorimetry; Carbonic Anhydrases; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Oxygen Isotopes; Point Mutation; Recombinant Proteins; Thermodynamics | 1998 |
Glutamate-459 is important for Escherichia coli branching enzyme activity.
Topics: 1,4-alpha-Glucan Branching Enzyme; Alanine; Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Conserved Sequence; Escherichia coli; Glutamic Acid; Glutamine; Glycogen; Hydrogen-Ion Concentration; Kinetics; Lysine; Mutagenesis, Site-Directed; Plant Proteins; Sequence Alignment | 1998 |
Excitatory amino acids as neurotransmitters of corticostriatal projections: immunocytochemical evidence in the rat.
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Glutamic Acid; Gold Colloid; Immunohistochemistry; Molecular Probes; Neurons; Neurotransmitter Agents; Rats; Synaptic Transmission; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 1998 |
Peroxynitrite causes aspartate release from dissociated rat cerebellar granule neurones.
Topics: Animals; Aspartic Acid; Brain Ischemia; Calcium; Cerebellar Cortex; Dithiothreitol; Egtazic Acid; Glutamic Acid; Ion Transport; Kainic Acid; Membrane Proteins; Nerve Tissue Proteins; Neurons; Nitrates; Nitric Oxide; Oxidants; Oxidation-Reduction; Rats; Rats, Wistar; Sodium; Sulfhydryl Compounds; Superoxides; Tetrodotoxin | 1998 |
Anion competition for a volume-regulated current.
Topics: Anions; Aspartic Acid; Biophysical Phenomena; Biophysics; Cell Membrane Permeability; Cell Size; Chlorides; Electric Conductivity; Glutamic Acid; Humans; Ion Transport; Kinetics; Membrane Potentials; Models, Biological; Thermodynamics; Tumor Cells, Cultured | 1998 |
Contribution of proton release to the B2 photocurrent of bacteriorhodopsin.
Topics: Aspartic Acid; Bacteriorhodopsins; Biophysical Phenomena; Biophysics; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Photochemistry; Protons; Schiff Bases | 1998 |
A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Aspartic Acid; Binding Sites; Fungal Proteins; Glutamic Acid; GTP-Binding Proteins; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Guanosine Diphosphate; Magnesium; Models, Molecular; Mutagenesis, Site-Directed; Phosphates; Protein Conformation | 1998 |
Determination of glutamate and aspartate in microdialysis samples by reversed-phase column liquid chromatography with fluorescence and electrochemical detection.
Topics: Animals; Aspartic Acid; Automation; Chromatography, High Pressure Liquid; Electrochemistry; Fluorescence; Glutamic Acid; Indicators and Reagents; Microdialysis; Rats | 1998 |
Glutamate mediates an inhibitory postsynaptic potential in dopamine neurons.
Topics: Action Potentials; Animals; Aspartic Acid; Caffeine; Calcium; Excitatory Postsynaptic Potentials; Glutamic Acid; Indoles; Male; Neural Inhibition; Potassium; Rats; Receptors, Glutamate; Ryanodine; Substantia Nigra; Synapses; Synaptic Transmission; Time Factors; Ventral Tegmental Area | 1998 |
Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic microdialysis experiments.
Topics: Amino Acids; Animals; Aspartic Acid; Electroencephalography; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Male; Microdialysis; Picrotoxin; Rats; Rats, Sprague-Dawley; Seizures; Taurine | 1998 |
Increased spinal release of excitatory amino acids following intradermal injection of capsaicin is reduced by a protein kinase G inhibitor.
Topics: Alkaloids; Animals; Aspartic Acid; Capsaicin; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Glutamic Acid; Indoles; Injections, Intradermal; Isoquinolines; Male; Rats; Rats, Sprague-Dawley; Spinal Cord; Sulfonamides | 1998 |
Glu78, from the conserved PEWY sequence of subunit IV, has a key function in cytochrome b6f turnover.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Chlamydomonas reinhardtii; Chloroplasts; Conserved Sequence; Cytochrome b Group; Cytochrome b6f Complex; Electron Transport; Glutamic Acid; Glutamine; Kinetics; Leucine; Lysine; Mutagenesis, Site-Directed; Oxidation-Reduction; Peptide Fragments; Transformation, Genetic | 1998 |
Neutralization of conservative charged transmembrane residues in the Na+/glucose cotransporter SGLT1.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Biological Transport; Glucose; Glutamic Acid; Kinetics; Lysine; Membrane Glycoproteins; Models, Molecular; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Phlorhizin; Protein Structure, Secondary; Rabbits; Sodium; Sodium-Glucose Transporter 1 | 1998 |
Roles of negatively charged surface residues of putidaredoxin in interactions with redox partners in p450cam monooxygenase system.
Topics: Aspartic Acid; Binding Sites; Camphor 5-Monooxygenase; Electricity; Electron Transport; Ferredoxins; Glutamic Acid; Models, Molecular; Mutagenesis, Site-Directed; NAD; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Potentiometry; Protein Binding; Protein Structure, Secondary; Spectrophotometry | 1998 |
Elevation of intraocular glutamate levels in rats with partial lesion of the optic nerve.
Topics: Animals; Aqueous Humor; Aspartic Acid; Cell Death; Chromatography, High Pressure Liquid; Glutamic Acid; Male; Nerve Crush; Nerve Degeneration; Nerve Fibers; Optic Nerve Diseases; Optic Nerve Injuries; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells | 1998 |
D-aspartate modulates melatonin synthesis in rat pinealocytes.
Topics: Animals; Arylamine N-Acetyltransferase; Aspartic Acid; Bucladesine; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media, Conditioned; Cyclic AMP; Dose-Response Relationship, Drug; Glutamic Acid; Melatonin; Organ Culture Techniques; Pineal Gland; Rats; Rats, Wistar; Time Factors | 1998 |
Acetyl phosphate and the phosphorylation of OmpR are involved in the regulation of the cell division rate in Escherichia coli.
Topics: Acetates; Aspartic Acid; Bacterial Proteins; Carbon; Cell Division; Culture Media; Escherichia coli; Flagella; Glutamic Acid; Models, Biological; Mutation; Organophosphates; Phosphate Acetyltransferase; Phosphorylation; Serine; Signal Transduction; Threonine; Trans-Activators | 1998 |
Methylmalonate toxicity in primary neuronal cultures.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Apoptosis; Aspartic Acid; Brain; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Electron Transport Complex II; Fetus; gamma-Aminobutyric Acid; Glutamic Acid; Kinetics; Methylmalonic Acid; Mice; Microscopy, Video; Multienzyme Complexes; Neurons; Oxidoreductases; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Succinate Dehydrogenase; Time Factors | 1998 |
Preserved catalytic activity in an engineered ribonucleotide reductase R2 protein with a nonphysiological radical transfer pathway. The importance of hydrogen bond connections between the participating residues.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Catalysis; Escherichia coli; Free Radicals; Glutamic Acid; Hydrogen Bonding; Iron; Protein Binding; Protein Engineering; Ribonucleotide Reductases; Tyrosine | 1998 |
Synaptic vesicular localization and exocytosis of L-aspartate in excitatory nerve terminals: a quantitative immunogold analysis in rat hippocampus.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Calcium; Electrophysiology; Exocytosis; Glutamic Acid; Glutamine; Hippocampus; Hypoglycemia; Immunohistochemistry; In Vitro Techniques; Nerve Endings; Rats; Rats, Wistar; Reference Values; Synaptic Vesicles; Tetanus Toxin; Tissue Distribution | 1998 |
Amino acid signatures in the normal cat retina.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cats; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Image Processing, Computer-Assisted; Immunohistochemistry; Neuroglia; Neurons; Pigment Epithelium of Eye; Retina; Taurine | 1998 |
Amino acid signatures in the detached cat retina.
Topics: Amino Acids; Animals; Aspartic Acid; Cats; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Image Processing, Computer-Assisted; Immunohistochemistry; Neuroglia; Neurons; Pigment Epithelium of Eye; Retina; Retinal Detachment; Taurine | 1998 |
Engineering the S1' subsite of trypsin: design of a protease which cleaves between dibasic residues.
Topics: Amino Acids, Diamino; Animals; Arginine; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Glutamic Acid; Hydrolysis; Kinetics; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Protein Engineering; Rats; Structure-Activity Relationship; Substrate Specificity; Trypsin | 1998 |
Molecular basis of recognition by Gal/GalNAc specific legume lectins: influence of Glu 129 on the specificity of peanut agglutinin (PNA) towards C2-substituents of galactose.
Topics: Acetylgalactosamine; Alanine; Amino Acid Sequence; Aspartic Acid; Base Sequence; Binding Sites; DNA Primers; Fabaceae; Galactose; Glutamic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Peanut Agglutinin; Plant Lectins; Plants, Medicinal | 1998 |
The release of amino acids from rat neostriatum and substantia nigra in vivo: a dual microdialysis probe analysis.
Topics: Animals; Aspartic Acid; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Male; Microdialysis; Neostriatum; Rats; Rats, Wistar; Substantia Nigra; Taurine | 1998 |
MR imaging and localized proton MR spectroscopy in late infantile neuronal ceroid lipofuscinosis.
Topics: Aspartic Acid; Brain; Brain Diseases; Case-Control Studies; Cerebellum; Cerebral Ventricles; Child; Child, Preschool; Choline; Creatine; Diagnosis, Differential; Female; Glutamic Acid; Glutamine; Humans; Inositol; Lactates; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mitochondrial Encephalomyopathies; Neuronal Ceroid-Lipofuscinoses; Peroxisomal Disorders; Thalamus | 1998 |
The mechanism of adenosylmethionine-dependent activation of methionine synthase: a rapid kinetic analysis of intermediates in reductive methylation of Cob(II)alamin enzyme.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acid Substitution; Aspartic Acid; Cobalt; Electron Transport; Enzyme Activation; Escherichia coli; Glutamic Acid; Histidine; Kinetics; Methylation; Models, Chemical; Mutagenesis, Site-Directed; Oxidation-Reduction; S-Adenosylmethionine; Transcobalamins; Vitamin B 12 | 1998 |
Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV).
Topics: Amygdala; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cyclopropanes; Glutamic Acid; Glycine; Kindling, Neurologic; Lamotrigine; Male; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Seizures; Synaptosomes; Triazines | 1998 |
A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese.
Topics: Adult; Aged; Amino Acid Substitution; Aspartic Acid; Coronary Vasospasm; Exons; Female; Genes, Dominant; Genetic Variation; Glutamic Acid; Heterozygote; Homozygote; Humans; Japan; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Point Mutation; Polymerase Chain Reaction | 1998 |
Nicotinic acetylcholine receptor mediated modulation of evoked excitatory amino acid release in the nucleus tractus solitarius of the rat: evidence from in vivo microdialysis.
Topics: Animals; Aspartic Acid; Glutamic Acid; Male; Mecamylamine; Microdialysis; Nicotinic Antagonists; Pressoreceptors; Rats; Rats, Inbred WKY; Receptors, Nicotinic; Solitary Nucleus | 1998 |
Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel.
Topics: Amino Acid Transport System X-AG; Animals; Anions; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Brain Chemistry; Chloride Channels; Cloning, Molecular; Electric Conductivity; Glutamic Acid; Humans; Ion Channel Gating; Kinetics; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Potassium; Protons; Sodium; Xenopus | 1998 |
Role of excitatory aminoacids in neonatal hypoglycemia.
Topics: Aspartic Acid; Copper; Excitatory Amino Acids; Glutamic Acid; Humans; Hypoglycemia; Infant, Newborn; Magnesium; Zinc | 1998 |
Changes in the extracellular levels of glutamate and aspartate during ischemia and hypoglycemia. Effects of hypothermia.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Extracellular Space; Glutamic Acid; Hypoglycemia; Hypothermia, Induced; Ischemic Attack, Transient; Male; Microdialysis; Rats; Rats, Wistar | 1998 |
Sound-evoked efflux of excitatory amino acids in the guinea-pig cochlea in vitro.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Cochlea; Electrophysiology; Fluorescent Antibody Technique; Glutamic Acid; Guinea Pigs; Hearing; Hemocyanins; Membrane Potentials; Neurons, Afferent; Organ Culture Techniques; Temporal Bone | 1998 |
The roles of threonine-136 and glutamate-137 of human medium chain acyl-CoA dehydrogenase in FAD binding and peptide folding using site-directed mutagenesis: creation of an FAD-dependent mutant, T136D.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Alum Compounds; Amino Acid Substitution; Animals; Aspartic Acid; Chromatography, Gel; Enzyme Activation; Enzyme Stability; Escherichia coli; Flavin-Adenine Dinucleotide; Fractional Precipitation; Gene Expression Regulation, Bacterial; Glutamic Acid; Humans; Mitochondria, Liver; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Folding; Protein Processing, Post-Translational; Rats; Riboflavin; Subcellular Fractions; Temperature; Threonine | 1998 |
A presynaptic N-methyl-D-aspartate autoreceptor in rat hippocampus modulating amino acid release from a cytoplasmic pool.
Topics: Animals; Aspartic Acid; Autoreceptors; Calcium; Cytoplasm; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Ion Channel Gating; Magnesium; Male; Microscopy, Electron; Neurotransmitter Agents; Potassium Chloride; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1998 |
Central effects of acamprosate: part 1. Acamprosate blocks the glutamate increase in the nucleus accumbens microdialysate in ethanol withdrawn rats.
Topics: Acamprosate; Alanine; Alcohol Deterrents; Alcoholism; Animals; Arginine; Aspartic Acid; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nucleus Accumbens; Rats; Rats, Wistar; Taurine | 1998 |
Changes in neurotransmitter release in the main olfactory bulb following an olfactory conditioning procedure in mice.
Topics: Animals; Aspartic Acid; Behavior, Animal; Carbohydrates; Citrulline; Conditioning, Psychological; Discrimination Learning; Female; gamma-Aminobutyric Acid; Glutamic Acid; Mice; Mice, Inbred BALB C; Microdialysis; Neurotransmitter Agents; Norepinephrine; Olfactory Bulb; Olfactory Receptor Neurons; Smell; Taurine | 1998 |
Cholinergic excitation of dendrites in neocortical neurons.
Topics: Acetylcholine; Animals; Aspartic Acid; Cholinergic Fibers; Dendrites; Glutamic Acid; Guinea Pigs; Iontophoresis; Membrane Potentials; Neocortex; Parietal Lobe; Pyramidal Cells; Reaction Time; Receptors, Muscarinic; Synaptic Transmission | 1998 |
Nitric oxide reduces hypophagia induced by threonine free diet in the rat.
Topics: Animals; Arginine; Aspartic Acid; Body Weight; Diet; Eating; Feeding Behavior; Glutamic Acid; Injections, Intraventricular; Male; Nitric Oxide; Nitroprusside; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Sulfhydryl Reagents; Threonine | 1998 |
Peroxynitrite generation might explain elevated glutamate and aspartate levels in multiple sclerosis cerebrospinal fluid.
Topics: Animals; Aspartic Acid; Glutamic Acid; Humans; Models, Biological; Multiple Sclerosis; Neurodegenerative Diseases; Nitrates; Nitric Oxide; Receptors, N-Methyl-D-Aspartate | 1998 |
Changes in the amygdala amino acid microdialysate after conditioning with a cue associated with ethanol.
Topics: Amygdala; Animals; Aspartic Acid; Conditioning, Classical; Ethanol; Glutamic Acid; Male; Rats; Rats, Wistar; Taurine | 1998 |
Proton uptake by carboxylic acid groups upon photoreduction of the secondary quinone (QB) in bacterial reaction centers from Rhodobacter sphaeroides: FTIR studies on the effects of replacing Glu H173.
Topics: Amino Acid Substitution; Aspartic Acid; Carboxylic Acids; Deuterium Oxide; Electron Transport; Glutamic Acid; Glutamine; Mutagenesis, Site-Directed; Photochemistry; Photosynthetic Reaction Center Complex Proteins; Protons; Quinones; Rhodobacter sphaeroides; Spectroscopy, Fourier Transform Infrared | 1998 |
Mivazerol inhibits intrathecal release of glutamate evoked by halothane withdrawal in rats.
Topics: Adrenergic alpha-Agonists; Anesthesia; Anesthetics, Inhalation; Animals; Aspartic Acid; Blood Pressure; Glutamic Acid; Halothane; Heart Rate; Imidazoles; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance Withdrawal Syndrome | 1998 |
Comparison of lactate and glucose metabolism in cultured neocortical neurons and astrocytes using 13C-NMR spectroscopy.
Topics: Animals; Aspartic Acid; Astrocytes; Carbon Isotopes; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Citric Acid Cycle; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Lactic Acid; Magnetic Resonance Spectroscopy; Mice; Neurons | 1998 |
Ketone bodies and brain glutamate and GABA metabolism.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Astrocytes; Brain; Cells, Cultured; Citrate (si)-Synthase; gamma-Aminobutyric Acid; Glutamic Acid; Ketone Bodies; Mice; Neuroglia; Neurons; Synaptosomes | 1998 |
Localized in vivo 13C-NMR of glutamate metabolism in the human brain: initial results at 4 tesla.
Topics: Aspartic Acid; Blood Glucose; Brain; Carbon Isotopes; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Magnetics; Models, Biological; Visual Cortex | 1998 |
Intraoperative microdialysis and tissue-pO2 measurement in human glioma.
Topics: Aspartic Acid; Brain Edema; Brain Neoplasms; Cell Death; Female; Frontal Lobe; Glioblastoma; Glutamic Acid; Humans; Male; Microdialysis; Monitoring, Intraoperative; Oxygen Consumption; Prognosis; Temporal Lobe | 1998 |
Relationship between excitatory amino acid release and outcome after severe human head injury.
Topics: Animals; Aspartic Acid; Brain Damage, Chronic; Brain Injuries; Cerebral Cortex; Excitatory Amino Acids; Glasgow Coma Scale; Glutamic Acid; Humans; Microdialysis; Outcome Assessment, Health Care; Prognosis; Rats | 1998 |
Design and synthesis of conformationally constrained inhibitors of high-affinity, sodium-dependent glutamate transporters.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Carrier Proteins; Cell Fractionation; Centrifugation, Density Gradient; Cerebellum; Computer Simulation; Drug Design; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Male; Models, Molecular; Molecular Conformation; Molecular Structure; Radioligand Assay; Rats; Rats, Sprague-Dawley; Sodium; Substrate Specificity; Symporters; Synaptosomes; Tritium | 1998 |
Glutamate uptake in Purkinje cells in rat cerebellar slices.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Cerebellum; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Excitatory Amino Acid Transporter 4; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; In Vitro Techniques; Iontophoresis; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Symporters | 1998 |
Corticosterone peak is responsible for stress-induced elevation of glutamate in the hippocampus.
Topics: Adrenalectomy; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Corticosterone; Drug Implants; Ether; Female; Glutamic Acid; Glutamine; Hippocampus; Microdialysis; Radioimmunoassay; Rats; Rats, Wistar; Stress, Physiological; Taurine | 1998 |
Impairment of excitatory amino acid transport in astroglial cells infected with the human immunodeficiency virus type 1.
Topics: Aspartic Acid; Astrocytes; Biological Transport; Gene Products, nef; Glioma; Glutamic Acid; HIV Envelope Protein gp120; HIV Envelope Protein gp41; HIV-1; Humans; nef Gene Products, Human Immunodeficiency Virus; Peptide Fragments; Tumor Cells, Cultured | 1998 |
Modulation of ischemia-evoked release of excitatory and inhibitory amino acids by adenosine A1 receptor agonist.
Topics: Adenosine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid; Male; Purinergic P1 Receptor Agonists; Rats; Rats, Inbred SHR; Regional Blood Flow; Taurine | 1998 |
Stability of neuroactive amino acids in cerebrospinal fluid under various conditions of processing and storage.
Topics: Amino Acids; Aspartic Acid; Glutamic Acid; Glycine; Humans; Intervertebral Disc Displacement; Specimen Handling; Taurine; Time Factors | 1998 |
Effect of amino acid cardioplegia on myocardial metabolism and function of ischemic canine heart.
Topics: Amino Acids; Animals; Aspartic Acid; Blood; Cardioplegic Solutions; Dogs; Glutamic Acid; Heart Arrest, Induced; Hot Temperature; Myocardial Reperfusion Injury; Myocardium | 1997 |
A common Glu298-->Asp (894G-->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and vascular complications in type 2 diabetes.
Topics: Albuminuria; Amino Acid Substitution; Angina Pectoris; Aspartic Acid; Cerebrovascular Disorders; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Exons; Genotype; Glutamic Acid; Humans; Middle Aged; Myocardial Infarction; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peripheral Vascular Diseases; Point Mutation; Risk Factors | 1998 |
Stability of trimeric OmpF porin: the contributions of the latching loop L2.
Topics: Alanine; Arginine; Aspartic Acid; Computer Simulation; Crystallography, X-Ray; Glutamic Acid; Glutamine; Hot Temperature; Ion Channel Gating; Models, Molecular; Mutagenesis, Site-Directed; Porins; Protein Structure, Secondary; Thermodynamics | 1998 |
Altering the purine specificity of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus by structure-based point mutations in the enzyme protein.
Topics: Adenine Phosphoribosyltransferase; Amino Acid Substitution; Animals; Arginine; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Enzyme Activation; Glutamic Acid; Guanine; Guanosine Monophosphate; Humans; Hypoxanthine Phosphoribosyltransferase; Isoleucine; Lysine; Mutagenesis, Site-Directed; Phenylalanine; Point Mutation; Purines; Ribonucleotides; Serine; Structure-Activity Relationship; Substrate Specificity; Tritrichomonas foetus; Tyrosine; Xanthine | 1998 |
Catalytic triad of microsomal epoxide hydrolase: replacement of Glu404 with Asp leads to a strongly increased turnover rate.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid; Base Sequence; Catalytic Domain; DNA Primers; Epoxide Hydrolases; Glutamic Acid; Kinetics; Microsomes, Liver; Molecular Sequence Data; Rats; Recombinant Proteins; Sequence Homology, Amino Acid | 1999 |
1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline increases extracellular serotonin and stimulates hydroxyl radical production in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Carbolines; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Homovanillic Acid; Hydroxybenzoates; Hydroxyindoleacetic Acid; Hydroxyl Radical; Male; Microdialysis; Rats; Rats, Wistar; Serotonin | 1998 |
Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway.
Topics: Alternative Splicing; Amino Acid Sequence; Aminoacyltransferases; Animals; Arabidopsis; Aspartic Acid; Base Sequence; beta-Galactosidase; Cell Line, Transformed; Cell Nucleus; Cysteine; Cytosol; DNA, Complementary; Drosophila melanogaster; Exons; Gene Expression Regulation; Glutamic Acid; Humans; Mice; Molecular Sequence Data | 1999 |
The hydrogen-bonding network of water molecules and the peptide backbone in the region connecting Asp83, Gly120, and Glu113 in bovine rhodopsin.
Topics: Animals; Aspartic Acid; Carboxylic Acids; Cattle; Glutamic Acid; Glycine; Hydrogen Bonding; Peptide Fragments; Protein Conformation; Rhodopsin; Spectroscopy, Fourier Transform Infrared; Water | 1998 |
Novel role of phosphorylation in Fe-S cluster stability revealed by phosphomimetic mutations at Ser-138 of iron regulatory protein 1.
Topics: Aconitate Hydratase; Aerobiosis; Alanine; Amino Acid Substitution; Anaerobiosis; Aspartic Acid; Binding Sites; Cytosol; Escherichia coli; Glutamic Acid; Iron Regulatory Protein 1; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Isoenzymes; Kinetics; Mutagenesis, Site-Directed; Phosphorylation; Protein Processing, Post-Translational; Recombinant Proteins; RNA-Binding Proteins; Serine | 1998 |
[The effect of wuto granules on the levels of excitatory amino acids in extracellullar fluid of rat hippocampus following cerebral ischemia].
Topics: Animals; Aspartic Acid; Blood-Brain Barrier; Brain Ischemia; Drugs, Chinese Herbal; Excitatory Amino Acids; Extracellular Space; Female; Glutamic Acid; Hippocampus; Male; Microdialysis; Rats; Rats, Wistar | 1997 |
Microdialysis of excitatory amino acids in the periaqueductal gray of the rat after unilateral peripheral inflammation.
Topics: Animals; Aspartic Acid; Cell Compartmentation; Chromatography, High Pressure Liquid; Encephalitis; Excitatory Amino Acids; Glutamic Acid; Male; Microdialysis; Nociceptors; Periaqueductal Gray; Rats; Rats, Sprague-Dawley | 1998 |
Glycerol affects the quantification of aspartate and glutamate in acid-hydrolyzed proteins.
Topics: Amino Acids; Aspartic Acid; Chromatography, Gas; Glutamic Acid; Glycerol; Hydrochloric Acid; Hydrolysis; Mass Spectrometry; Mesylates; Proteins; Sigma Factor | 1998 |
Synthesis and proteinase inhibitory properties of diphenyl phosphonate analogues of aspartic and glutamic acids.
Topics: Aspartic Acid; Catalysis; Glutamic Acid; Hydrolysis; Kinetics; Organophosphonates; Protease Inhibitors; Serine Endopeptidases | 1998 |
Identification of carboxyl residues in pepstatin-insensitive carboxyl proteinase from Pseudomonas sp. 101 that participate in catalysis and substrate binding.
Topics: Amino Acid Sequence; Aspartic Acid; Aspartic Acid Endopeptidases; Bacterial Proteins; Binding Sites; Catalytic Domain; Dicyclohexylcarbodiimide; Enzyme Activation; Glutamic Acid; Hydrogen-Ion Concentration; Methanol; Molecular Sequence Data; Oligopeptides; Pepstatins; Peptides; Protease Inhibitors; Pseudomonas; Serine Endopeptidases; Substrate Specificity | 1999 |
Transient inhibition of glutamate uptake in vivo induces neurodegeneration when energy metabolism is impaired.
Topics: Animals; Antihypertensive Agents; Aspartic Acid; Biological Transport; Brain Chemistry; Corpus Striatum; Dicarboxylic Acids; Energy Metabolism; Glutamic Acid; Hippocampus; Male; Microdialysis; Nerve Degeneration; Neurotoxins; Neurotransmitter Uptake Inhibitors; Nitro Compounds; Propionates; Pyrrolidines; Rats; Rats, Wistar | 1999 |
Effects of pH changes on systems ASC and B in rabbit ileum.
Topics: Amino Acid Transport Systems; Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Chlorides; Female; Glutamic Acid; Hydrogen; Hydrogen-Ion Concentration; Ileum; Jejunum; Kinetics; Microvilli; Rabbits; Serine; Sodium | 1999 |
Mutagenesis of glutamate 820 of the gastric H+,K+-ATPase alpha-subunit to aspartate decreases the apparent ATP affinity.
Topics: Adenosine Triphosphate; Aspartic Acid; Glutamic Acid; H(+)-K(+)-Exchanging ATPase; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Temperature | 1999 |
Site-directed mutagenesis of putative active site residues of 5-enolpyruvylshikimate-3-phosphate synthase.
Topics: 3-Phosphoshikimate 1-Carboxyvinyltransferase; Alanine; Alkyl and Aryl Transferases; Amino Acid Substitution; Arginine; Aspartic Acid; Binding Sites; Catalysis; Enzyme Activation; Escherichia coli; Glutamic Acid; Lysine; Mutagenesis, Site-Directed; Plasmids; Recombinant Proteins | 1999 |
Calcium binding to the class I alpha-1,2-mannosidase from Saccharomyces cerevisiae occurs outside the EF hand motif.
Topics: Asparagine; Aspartic Acid; Binding Sites; Calcium; Calcium-Binding Proteins; Catalysis; Enzyme Stability; Glutamic Acid; Glutamine; Hot Temperature; Kinetics; Mannosidases; Mutagenesis, Site-Directed; Peptide Fragments; Recombinant Proteins; Saccharomyces cerevisiae | 1999 |
Coronary artery disease is not associated with the E298-->D variant of the constitutive, endothelial nitric oxide synthase gene.
Topics: Aspartic Acid; Case-Control Studies; Coronary Disease; Genotype; Glutamic Acid; Humans; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Point Mutation | 1998 |
Glutamine synthesis is heterogeneous and differentially regulated along the rabbit renal proximal tubule.
Topics: Alanine; Animals; Aspartic Acid; Glutamic Acid; Glutamine; In Vitro Techniques; Kidney Tubules, Proximal; Male; Rabbits | 1999 |
Is glutamine a pretender to the throne?
Topics: Arginine; Asparagine; Aspartic Acid; Dipeptides; Glutamic Acid; Glutamine; Humans; Parenteral Nutrition, Total | 1999 |
Thiamin-binding protein from sunflower seeds.
Topics: Asparagine; Aspartic Acid; Carrier Proteins; Chromatography, Gel; Glutamic Acid; Glutamine; Helianthus; Hydrogen-Ion Concentration; Molecular Weight; Seeds; Thiamine | 1998 |
Site-directed mutagenesis of charged and potentially proton-carrying residues in the beta subunit of the proton-translocating nicotinamide nucleotide transhydrogenase from Escherichia coli. Characterization of the beta H91, beta D392, and beta K424 mutant
Topics: Aspartic Acid; Biological Transport; Catalysis; Conserved Sequence; Enzyme Activation; Escherichia coli; Glutamic Acid; Histidine; Hydrogen-Ion Concentration; Lysine; Magnesium Chloride; Mutagenesis, Site-Directed; NADP; NADP Transhydrogenases; Proton Pumps; Recombinant Proteins; Sodium Chloride | 1999 |
Inhibition of ischemia-induced glutamate release in rat striatum by dihydrokinate and an anion channel blocker.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Blood Flow Velocity; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Corpus Striatum; Drug Therapy, Combination; Glutamic Acid; Ion Pumps; Kainic Acid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Stilbenes | 1999 |
The use of neamine as a molecular template: identification of active site residues in the bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa by mass spectroscopy.
Topics: Aspartic Acid; Binding Sites; Drug Resistance, Microbial; Glutamic Acid; Kanamycin Kinase; Molecular Probes; Neomycin; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 1998 |
3H-L-glutamate binding and 3H-D-aspartate release from hippocampal tissue during the development of pentylenetetrazole kindling in rats.
Topics: Animals; Aspartic Acid; GABA Antagonists; Glutamic Acid; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Wistar; Synaptic Membranes; Tritium | 1999 |
In vivo quantitation of cerebral metabolite concentrations using natural abundance 13C MRS at 1.5 T.
Topics: Aspartic Acid; Brain; Canavan Disease; Carbon Isotopes; Child; Child, Preschool; Glutamic Acid; Glutamine; Humans; Hydrogen Bonding; Infant; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Sensitivity and Specificity; Spin Labels; Synaptic Transmission | 1999 |
Two serine residues of the glutamate transporter GLT-1 are crucial for coupling the fluxes of sodium and the neurotransmitter.
Topics: Amino Acid Substitution; Amino Acid Transport System X-AG; Aspartic Acid; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport; Glutamic Acid; Glycine; HeLa Cells; Humans; Kainic Acid; Kinetics; Mutagenesis, Site-Directed; Neurotransmitter Agents; Recombinant Proteins; Serine; Sodium | 1999 |
Electrochemical and ultraviolet/visible/infrared spectroscopic analysis of heme a and a3 redox reactions in the cytochrome c oxidase from Paracoccus denitrificans: separation of heme a and a3 contributions and assignment of vibrational modes.
Topics: Arginine; Aspartic Acid; Electrochemistry; Electron Transport Complex IV; Glutamic Acid; Heme; Molecular Conformation; Oxidation-Reduction; Paracoccus denitrificans; Porphyrins; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Tyrosine | 1999 |
Role of the buried glutamate in the alpha-helical coiled coil domain of the macrophage scavenger receptor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid; Cattle; Glutamic Acid; Glutamine; Histidine; Humans; Hydrogen-Ion Concentration; Macrophages; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Protein Conformation; Protein Structure, Secondary; Rabbits; Receptors, Immunologic; Receptors, Scavenger; Sequence Analysis; Valine | 1999 |
The proton release group of bacteriorhodopsin controls the rate of the final step of its photocycle at low pH.
Topics: Aspartic Acid; Azides; Bacteriorhodopsins; Catalysis; Deuterium Oxide; Glutamic Acid; Glutamine; Halobacterium salinarum; Hydrogen-Ion Concentration; Mathematical Computing; Models, Chemical; Mutagenesis, Site-Directed; Photochemistry; Protons; Titrimetry | 1999 |
Electron transfer induces side-chain conformational changes of glutamate-286 from cytochrome bo3.
Topics: Aspartic Acid; Cyanides; Cytochrome b Group; Cytochromes; Electron Transport; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Conformation; Protons; Solvents; Spectroscopy, Fourier Transform Infrared | 1999 |
Effects of competitive NMDA receptor antagonists on excitatory amino acid-evoked currents in mouse spinal cord neurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding, Competitive; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Interaction of the N-terminus of chicken skeletal essential light chain 1 with F-actin.
Topics: Actins; Alanine; Amino Acid Sequence; Animals; Aspartic Acid; Carbodiimides; Chickens; Cross-Linking Reagents; Glutamic Acid; Lysine; Molecular Sequence Data; Muscle, Skeletal; Mutagenesis, Site-Directed; Myosin Light Chains; Peptide Fragments; Proline; Sequence Deletion | 1999 |
A novel variant of transthyretin (Glu42Asp) associated with sporadic late-onset cardiac amyloidosis.
Topics: Age of Onset; Amino Acid Substitution; Amyloidosis; Aspartic Acid; Base Sequence; DNA; Glutamic Acid; Heart Diseases; Humans; Immunohistochemistry; Male; Middle Aged; Polymerase Chain Reaction; Prealbumin | 1998 |
Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities.
Topics: Amino Acids; Animals; Aryldialkylphosphatase; Aspartic Acid; Binding Sites; Bromosuccinimide; Calcium Radioisotopes; Cell Line; Dicyclohexylcarbodiimide; Diethyl Pyrocarbonate; Enzyme Activation; Enzyme Inhibitors; Esterases; Glutamic Acid; Glycosylation; Histidine; Humans; Indicators and Reagents; Kidney; Kinetics; Mutagenesis, Site-Directed; Protein Conformation; Rabbits; Recombinant Proteins; Spectrometry, Fluorescence; Terbium; Tryptophan | 1999 |
Properties of an L-glutamate-induced acid tolerance response which involves the functioning of extracellular induction components.
Topics: Aspartic Acid; Escherichia coli; Glutamate Decarboxylase; Glutamic Acid; Hydrogen-Ion Concentration | 1999 |
The contribution of acidic residues to the conformational stability of common-type acylphosphatase.
Topics: Acid Anhydride Hydrolases; Acylphosphatase; Amino Acid Substitution; Asparagine; Aspartic Acid; Enzyme Stability; Glutamic Acid; Glutamine; Humans; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Fusion Proteins; Substrate Specificity | 1999 |
The effects of excitatory amino acids on isolated gut segments of the rat.
Topics: Animals; Aspartic Acid; Cycloleucine; Digestive System; Digestive System Physiological Phenomena; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Female; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; N-Methylaspartate; Neuroprotective Agents; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Glutamate/aspartate and leu-enkephalin immunoreactivity in mammillothalamic projection neurons of the rat.
Topics: Animals; Aspartic Acid; Axons; Enkephalin, Leucine; Female; Glutamic Acid; Limbic System; Male; Mammillary Bodies; Microinjections; Neurons; Rats; Rats, Wistar; Thalamic Nuclei; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate | 1998 |
Simultaneous determination of basal and evoked output levels of aspartate, glutamate, taurine and 4-aminobutyric acid during microdialysis and from superfused brain slices.
Topics: Animals; Aspartic Acid; Brain Chemistry; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Male; Microdialysis; Potassium; Rats; Rats, Sprague-Dawley; Rats, Wistar; Taurine | 1999 |
[Levels of neurotransmitter amino acids in the cerebrospinal fluid of patients with acute ischemic stroke].
Topics: Acute Disease; Aspartic Acid; Brain Ischemia; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Neurotransmitter Agents; Prognosis; Time Factors | 1999 |
Amino acid release during spreading depression in a flow-compromised cortical area.
Topics: Alanine; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Cerebrovascular Circulation; Cortical Spreading Depression; Glutamic Acid; Male; Membrane Potentials; Rats; Rats, Inbred F344; Taurine | 1999 |
A novel glutamic acid to aspartic acid mutation near the end of the 2B rod domain in the keratin 1 chain in epidermolytic hyperkeratosis.
Topics: Amino Acid Substitution; Aspartic Acid; Base Sequence; Female; Glutamic Acid; Humans; Hyperkeratosis, Epidermolytic; Intermediate Filaments; Keratins; Male; Pedigree | 1999 |
Aspartate-27 and glutamate-473 are involved in catalysis by Zymomonas mobilis pyruvate decarboxylase.
Topics: Aspartic Acid; Catalysis; Electrophoresis, Polyacrylamide Gel; Glutamic Acid; Kinetics; Mutagenesis, Site-Directed; Protein Conformation; Pyruvate Decarboxylase; Substrate Specificity; Thiamine Pyrophosphate; Zymomonas | 1999 |
Analysis of CSF amino acids in young patients with generalised refractory epilepsy during an add-on study with lamotrigine.
Topics: Adolescent; Adult; Amino Acids; Anticonvulsants; Aspartic Acid; Child; Child, Preschool; Drug Resistance; Drug Therapy, Combination; Epilepsy, Generalized; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Lamotrigine; Male; Treatment Outcome; Triazines | 1999 |
Raman markers of nonaromatic side chains in an alpha-helix assembly: Ala, Asp, Glu, Gly, Ile, Leu, Lys, Ser, and Val residues of phage fd subunits.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Deuterium; DNA, Single-Stranded; Glutamic Acid; Glycine; Inovirus; Isoleucine; Lysine; Molecular Sequence Data; Protein Structure, Secondary; Serine; Spectrum Analysis, Raman; Valine; Viral Proteins; Virus Assembly | 1999 |
Modulating electron density in the bound product, 4-hydroxybenzoyl-CoA, by mutations in 4-chlorobenzoyl-CoA dehalogenase near the 4-hydroxy group.
Topics: Acyl Coenzyme A; Alanine; Aspartic Acid; Binding Sites; Electrons; Glutamic Acid; Hydrolases; Models, Chemical; Mutagenesis, Site-Directed; Protein Binding; Pseudomonas; Serine; Spectrum Analysis, Raman | 1999 |
Site-directed mutants of charged residues in the active site of tyrosine hydroxylase.
Topics: Amino Acid Substitution; Arginine; Aspartic Acid; Binding Sites; Conserved Sequence; Escherichia coli; Glutamic Acid; Histidine; Kinetics; Mutagenesis, Site-Directed; Recombinant Proteins; Tyrosine 3-Monooxygenase | 1999 |
Involvement of microglia in cerebrospinal fluid glutamate increase in SIV-infected rhesus monkeys (Macaca mulatta).
Topics: Animals; Aspartic Acid; Cells, Cultured; gamma-Aminobutyric Acid; Glutamic Acid; HIV Antigens; Macaca mulatta; Microglia; Simian Acquired Immunodeficiency Syndrome | 1999 |
Striatal A2A adenosine receptors differentially regulate spontaneous and K+-evoked glutamate release in vivo in young and aged rats.
Topics: Adenosine; Aging; Animals; Aspartic Acid; Extracellular Space; Glutamic Acid; Male; Microdialysis; Neostriatum; Phenethylamines; Potassium; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1 | 1999 |
Changes in the extracellular profiles of neuroactive amino acids in the rat striatum at the asymptomatic stage of hepatic failure.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Biological Transport; Corpus Striatum; Excitatory Amino Acids; Fatty Liver; Gliosis; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Liver; Male; Microdialysis; Potassium; Rats; Rats, Wistar; Taurine; Thioacetamide | 1999 |
Double-mutant analysis of the interaction of Ras with the Ras-binding domain of RGL.
Topics: Alanine; Amino Acid Sequence; Animals; Aspartic Acid; Glutamic Acid; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Histidine; Humans; Lysine; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Protein Binding; ras Proteins; Rats; Recombinant Fusion Proteins; Static Electricity; Tyrosine | 1999 |
Effects of mutation of the conserved glutamic acid-286 in subunit I of cytochrome c oxidase from Rhodobacter sphaeroides.
Topics: Aspartic Acid; Binding Sites; Catalysis; Conserved Sequence; Electron Transport Complex IV; Ferric Compounds; Formates; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Ligands; Mutagenesis, Site-Directed; Oxidation-Reduction; Rhodobacter sphaeroides | 1999 |
Nuclear magnetic resonance and restrained molecular dynamics studies of the interaction of an epidermal growth factor-derived peptide with protein tyrosine phosphatase 1B.
Topics: Alanine; Aspartic Acid; Binding, Competitive; Crystallography, X-Ray; ErbB Receptors; Glutamic Acid; Leucine; Ligands; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Phenylalanine; Phosphotyrosine; Protein Binding; Protein Conformation; Protein Tyrosine Phosphatases; Temperature; Thermodynamics | 1999 |
Effects of anion channel blockers on hyposmotically induced amino acid release from the in vivo rat cerebral cortex.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amino Acids; Animals; Anions; Aspartic Acid; Cerebral Cortex; Ethanolamines; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hypotonic Solutions; Ion Channels; Male; Niflumic Acid; Rats; Rats, Sprague-Dawley; Sodium Chloride; Tamoxifen; Taurine | 1999 |
Structure/activity studies of the anti-MUC1 monoclonal antibody C595 and synthetic MUC1 mucin-core-related peptides and glycopeptides.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Aspartic Acid; Binding, Competitive; Circular Dichroism; Epitopes; Glutamic Acid; Glycopeptides; Glycosylation; Humans; Hydrogen-Ion Concentration; Immunoglobulin G; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mucin-1; Peptide Fragments; Protein Denaturation; Spectrometry, Fluorescence; Structure-Activity Relationship; Temperature; Thermodynamics; Titrimetry; Tryptophan; Tyrosine | 1999 |
Conversion of a bacterial warm sensor to a cold sensor by methylation of a single residue in the presence of an attractant.
Topics: Aspartic Acid; Bacterial Proteins; Carboxylic Ester Hydrolases; Cell Movement; Chemoreceptor Cells; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Hot Temperature; Membrane Proteins; Methylation; Methyltransferases; Mutation; Receptors, Cell Surface; Signal Transduction; Structure-Activity Relationship | 1999 |
Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase.
Topics: Acid Anhydride Hydrolases; Adenine Nucleotides; Adenosine Triphosphatases; Alanine; Amino Acid Sequence; Animals; Aspartic Acid; Brain; Chymotrypsin; Conserved Sequence; COS Cells; Enzyme Inhibitors; Escherichia coli; Glutamic Acid; Humans; Hydrolysis; Molecular Sequence Data; Mutagenesis, Site-Directed; Nucleoside-Triphosphatase; Protein Folding; Sodium Azide; Transfection; Triazines; Tryptophan | 1999 |
DNA cleavage by the EcoRV restriction endonuclease: pH dependence and proton transfers in catalysis.
Topics: Amino Acid Substitution; Aspartic Acid; Catalysis; Chlorides; Deoxyribonucleases, Type II Site-Specific; Dimerization; DNA, Bacterial; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Manganese Compounds; Mutagenesis, Site-Directed; Protein Conformation; Protons; Water | 1999 |
Coordination of spinal locomotor activity in the lamprey: long-distance coupling of spinal oscillators.
Topics: Animals; Aspartic Acid; Brain Stem; Computer Simulation; Glutamic Acid; In Vitro Techniques; Lampreys; Larva; Models, Neurological; Motor Activity; Neurons; Oscillometry; Psychomotor Performance; Reaction Time; Regression Analysis; Spinal Cord; Strychnine | 1999 |
Developmental sex differences in amino acid neurotransmitter levels in hypothalamic and limbic areas of rat brain.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamus; Limbic System; Male; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Sex Characteristics; Testosterone | 1999 |
Nontransportable inhibitors attenuate reversal of glutamate uptake in synaptosomes following a metabolic insult.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Brain; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Pyrrolidines; Rats; Synaptosomes; Tritium | 1999 |
A proton magnetic resonance spectroscopy study of the striatum and cerebral cortex in Parkinson's disease.
Topics: Aged; Aspartic Acid; Cerebral Cortex; Choline; Corpus Striatum; Creatine; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Movement Disorders; Parietal Lobe; Parkinson Disease; Reference Values; Temporal Lobe | 1999 |
[1-(13)C]glucose metabolism in the tumoral and nontumoral cerebral tissue of a glioma-bearing rat.
Topics: Alanine; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Body Weight; Brain; Brain Neoplasms; Carbon Isotopes; Citric Acid Cycle; Female; Functional Laterality; gamma-Aminobutyric Acid; Glioma; Glucose; Glutamic Acid; Glutamine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Models, Chemical; Nerve Tissue Proteins; Rats; Rats, Wistar; Tumor Cells, Cultured | 1999 |
Biochemical evidence for heme linkage through esters with Asp-93 and Glu-241 in human eosinophil peroxidase. The ester with Asp-93 is only partially formed in vivo.
Topics: Amino Acid Sequence; Aspartic Acid; Chromatography, High Pressure Liquid; Eosinophil Peroxidase; Eosinophils; Esters; Glutamic Acid; Heme; Humans; Lactoperoxidase; Molecular Sequence Data; Oligopeptides; Peroxidases; Sequence Analysis | 1999 |
Acidic residues involved in cation and substrate interactions in the Na+/dicarboxylate cotransporter, NaDC-1.
Topics: Alanine; Amino Acid Substitution; Animals; Aspartic Acid; Carrier Proteins; Cations, Monovalent; Dicarboxylic Acid Transporters; Glutamic Acid; Immunoblotting; Kinetics; Lithium; Membrane Proteins; Mutagenesis, Site-Directed; Oocytes; Organic Anion Transporters, Sodium-Dependent; Patch-Clamp Techniques; Rabbits; Sodium; Substrate Specificity; Succinates; Symporters; Xenopus | 1999 |
Measurement of urinary amino acids using high-performance liquid chromatography equipped with a strong cation exchange resin pre-column.
Topics: Amino Acids; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Glutamic Acid; Glutamine; Humans; Reproducibility of Results | 1999 |
Histological changes and neurotransmitter levels three months following perinatal asphyxia in the rat.
Topics: Animals; Animals, Newborn; Arginine; Aspartic Acid; Asphyxia; Brain; Cell Count; Cerebellum; Corpus Striatum; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Histamine; Hydroxyindoleacetic Acid; Hypothalamus; Neurons; Neurotransmitter Agents; Pregnancy; Rats; Rats, Sprague-Dawley; Serotonin; Taurine; Time Factors | 1999 |
[Decrease of cAMP and increase of amino acids contents in mouse brain after dihydroetorphine tolerance].
Topics: Amino Acids; Analgesics, Opioid; Animals; Aspartic Acid; Brain; Cyclic AMP; Drug Tolerance; Etorphine; gamma-Aminobutyric Acid; Glutamic Acid; Mice | 1998 |
Characterization of the Ca2+-dependent binding of annexin IV to surfactant protein A.
Topics: Animals; Annexin A4; Aspartic Acid; Binding Sites; Calcium; Glutamic Acid; Mutation; Protein Binding; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Rats | 1999 |
Brevetoxins cause acute excitotoxicity in primary cultures of rat cerebellar granule neurons.
Topics: Animals; Aspartic Acid; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Glutamic Acid; L-Lactate Dehydrogenase; Marine Toxins; Neurons; Neurotoxins; Oxocins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1999 |
L-Glutamate and insulin enhance glycogen synthesis in cultured astrocytes from the rat brain through different intracellular mechanisms.
Topics: Androstadienes; Animals; Aspartic Acid; Astrocytes; Brain; Carbon Radioisotopes; Cells, Cultured; Deoxyglucose; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Glucose; Glutamic Acid; Glycogen; Glycogen Synthase; Insulin; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Wortmannin | 1999 |
An unexpected role for the active site base in cofactor orientation and flexibility in the copper amine oxidase from Hansenula polymorpha.
Topics: Amine Oxidase (Copper-Containing); Ammonia; Asparagine; Aspartic Acid; Binding Sites; Carbon; Deuterium; Enzyme Activation; Glutamic Acid; Hydrogen; Methylamines; Mutagenesis, Site-Directed; Oxygen; Pichia; Schiff Bases; Solvents; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Substrate Specificity; Viscosity | 1999 |
The active site base controls cofactor reactivity in Escherichia coli amine oxidase: x-ray crystallographic studies with mutational variants.
Topics: Amine Oxidase (Copper-Containing); Asparagine; Aspartic Acid; Binding Sites; Crystallization; Crystallography, X-Ray; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Glutamic Acid; Kinetics; Mass Spectrometry; Metals; Models, Molecular; Mutagenesis, Site-Directed; Pyridones; Spectrophotometry, Ultraviolet | 1999 |
A self-consistent, microenvironment modulated screened coulomb potential approximation to calculate pH-dependent electrostatic effects in proteins.
Topics: Algorithms; Animals; Aprotinin; Aspartic Acid; Calbindins; Computer Simulation; Glutamic Acid; HIV Protease; Hydrogen-Ion Concentration; Muramidase; Nerve Tissue Proteins; Ovomucin; Protein Conformation; Proteins; Ribonucleases; S100 Calcium Binding Protein G; Static Electricity | 1999 |
A multinuclear NMR study of the active site of an endoglucanase from a strain of Bacillus. Use of Trp residues as structural probes.
Topics: Amino Acid Sequence; Aspartic Acid; Bacillus; Binding Sites; Cellulase; Clostridium; Deuterium; Glutamic Acid; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Sequence Alignment; Tryptophan | 1999 |
Metabolic features of the adaptive effect of delta-sleep inducing peptide and piracetam under hyperoxic conditions.
Topics: Adaptation, Physiological; Animals; Aspartic Acid; Cerebral Cortex; Delta Sleep-Inducing Peptide; gamma-Aminobutyric Acid; Glutamic Acid; Hyperoxia; Male; Mitochondria; Myelin Sheath; Oxygen; Piracetam; Rats; Synaptosomes | 1999 |
Effect of CGP 36742 on the extracellular level of neurotransmitter amino acids in the thalamus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kinetics; Male; Microdialysis; Neurotransmitter Agents; Organophosphorus Compounds; Rats; Rats, Wistar; Receptors, GABA-B; tau Proteins; Thalamus | 1999 |
Changing patterns of spatial buffering of glutamate in developing rat retinae are mediated by the Müller cell glutamate transporter GLAST.
Topics: Aging; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Biological Transport; Glutamic Acid; Photoreceptor Cells, Vertebrate; Rats; Rats, Wistar; Retina | 1999 |
Phosphorylation and/or presence of serine 37 in the movement protein of tomato mosaic tobamovirus is essential for intracellular localization and stability in vivo.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Binding Sites; Fluorescence; Glutamic Acid; Green Fluorescent Proteins; Intracellular Fluid; Luminescent Proteins; Molecular Sequence Data; Mutagenesis; Nicotiana; Phosphoamino Acids; Phosphorylation; Plant Viral Movement Proteins; Plants, Toxic; Protoplasts; Recombinant Fusion Proteins; Serine; Solanum lycopersicum; Threonine; Tobamovirus; Viral Proteins | 1999 |
The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1.
Topics: Aspartic Acid; DNA-Binding Proteins; Enzyme Repression; Gene Expression Regulation, Fungal; Glucose; Glutamic Acid; Glutathione Transferase; Kluyveromyces; Mutagenesis, Site-Directed; Phosphorylation; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Substrate Specificity | 1999 |
Differential regulation of glutamate, aspartate and gamma-amino-butyrate release by N-methyl-D-aspartate receptors in rat striatum after partial and extensive lesions to the nigro-striatal dopamine pathway.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Homeostasis; Kinetics; Male; Microdialysis; Oxidopamine; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substantia Nigra | 1999 |
Inhibition of glutamine transport in rat brain mitochondria by some amino acids and tricarboxylic acid cycle intermediates.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Biological Transport; Brain; Citric Acid Cycle; Glutamic Acid; Glutamine; Ketoglutaric Acids; Kinetics; Malates; Mitochondria; Rats; Rats, Wistar; Succinic Acid | 1999 |
1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla.
Topics: Adult; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Brain; Female; Glutamic Acid; Glutamine; Humans; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Medulla Oblongata; Middle Aged; Nerve Degeneration; Reference Values | 1999 |
Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate-Ammonia Ligase; Glutamic Acid; Hippocampus; Neurotoxins; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetrodotoxin | 1999 |
Proton NMR investigation of the heme active site structure of an engineered cytochrome c peroxidase that mimics manganese peroxidase.
Topics: Arginine; Aspartic Acid; Binding Sites; Cyanides; Cytochrome-c Peroxidase; Glutamic Acid; Glycine; Heme; Histidine; Leucine; Molecular Mimicry; Nuclear Magnetic Resonance, Biomolecular; Peroxidases; Protein Engineering; Protons; Spectrophotometry; Valine | 1999 |
Increase in glutamate-aspartate transporter (GLAST) mRNA during kanamycin-induced cochlear insult in rats.
Topics: Amino Acid Transport System X-AG; Animals; Anti-Bacterial Agents; Aspartic Acid; ATP-Binding Cassette Transporters; Base Sequence; Cochlea; DNA Primers; Evoked Potentials, Auditory, Brain Stem; Gene Expression; Glutamic Acid; Hair Cells, Auditory; Kanamycin; Male; Rats; Rats, Wistar; RNA, Messenger | 1999 |
Electrochemical, FTIR, and UV/VIS spectroscopic properties of the ba(3) oxidase from Thermus thermophilus.
Topics: Arginine; Aspartic Acid; Buffers; Cytochrome b Group; Deuterium Oxide; Electrochemistry; Electron Transport Complex IV; Glutamic Acid; Heme; Lysine; Oxidation-Reduction; Peptides; Phosphates; Porphyrins; Potentiometry; Propionates; Protein Conformation; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Thermus thermophilus; Tyrosine; Water | 1999 |
Receptor activation by human C5a des Arg74 but not intact C5a is dependent on an interaction between Glu199 of the receptor and Lys68 of the ligand.
Topics: Animals; Antigens, CD; Arginine; Aspartic Acid; Complement C5a, des-Arginine; Glutamic Acid; Hexosaminidases; Humans; Iodine Radioisotopes; Ligands; Lysine; Monocytes; Mutagenesis, Site-Directed; Peptide Fragments; Rats; Receptor, Anaphylatoxin C5a; Receptors, Complement; Recombinant Proteins; Transfection; Tumor Cells, Cultured; U937 Cells | 1999 |
Role of reductase domain cluster 1 acidic residues in neuronal nitric-oxide synthase. Characterization of the FMN-FREE enzyme.
Topics: 2,6-Dichloroindophenol; Amino Acid Sequence; Amino Acids, Dicarboxylic; Aspartic Acid; Calmodulin; Conserved Sequence; Cytochrome c Group; Electron Transport; Enzyme Activation; Ferricyanides; Flavin Mononucleotide; Flavoproteins; Fluorescence; Glutamic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Sequence Homology, Amino Acid | 1999 |
No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke.
Topics: Aged; Alleles; Aspartic Acid; Brain Ischemia; Cerebrovascular Disorders; Female; Genotype; Glutamic Acid; Humans; Male; Middle Aged; Nitric Oxide Synthase; Odds Ratio; Polymorphism, Genetic | 1999 |
K(+)-induced reversal of astrocyte glutamate uptake is limited by compensatory changes in intracellular Na+.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Astrocytes; Cell Survival; Cells, Cultured; Culture Media; Energy Metabolism; Glutamic Acid; Glycolysis; Oxidation-Reduction; Potassium; Prosencephalon; Rats; Rats, Sprague-Dawley; Sodium | 1999 |
Amino acids in the Martian meteorite Nakhla.
Topics: Alanine; Amino Acids; Aspartic Acid; beta-Alanine; Egypt; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Mars; Meteoroids | 1999 |
Fourier transform infrared spectra of a late intermediate of the bacteriorhodopsin photocycle suggest transient protonation of Asp-212.
Topics: Aspartic Acid; Bacteriorhodopsins; Glutamic Acid; Glutamine; Halobacterium salinarum; Kinetics; Photolysis; Photoperiod; Protons; Spectroscopy, Fourier Transform Infrared; Time Factors | 1999 |
Relocation of the catalytic carboxylate group in class A beta-lactamase: the structure and function of the mutant enzyme Glu166-->Gln:Asn170-->Asp.
Topics: Acylation; Anti-Bacterial Agents; Asparagine; Aspartic Acid; beta-Lactamases; beta-Lactams; Catalytic Domain; Crystallography, X-Ray; Glutamic Acid; Glutamine; Kinetics; Models, Molecular; Mutation; Protein Conformation; Staphylococcus aureus; Structure-Activity Relationship | 1999 |
Analysis of the substrate specificity of human sulfotransferases SULT1A1 and SULT1A3: site-directed mutagenesis and kinetic studies.
Topics: Alanine; Amino Acid Substitution; Arylsulfotransferase; Aspartic Acid; Binding Sites; Dopamine; Enzyme Activation; Gene Expression Regulation, Enzymologic; Genes, Overlapping; Glutamic Acid; Glutamine; Humans; Kinetics; Mutagenesis, Site-Directed; Nuclear Proteins; Phenols; Recombinant Proteins; RNA-Binding Proteins; Saccharomyces cerevisiae Proteins; Substrate Specificity; Transcription Factors | 1999 |
Characterization of residues in human IgE and IgG binding site by chemical modification of ovomucoid third domain.
Topics: Acylation; Alkylation; Aspartic Acid; Binding Sites; Child, Preschool; Circular Dichroism; Female; Glutamic Acid; Histidine; Humans; Immunoglobulin E; Immunoglobulin G; Infant; Lysine; Ovomucin; Protein Structure, Secondary; Structure-Activity Relationship; Tetranitromethane; Tyrosine | 1999 |
Characterization of the Asp94 and Glu242 mutants in myeloperoxidase, the residues linking the heme group via ester bonds.
Topics: Aspartic Acid; Esters; Glutamic Acid; Heme; Kinetics; Mutagenesis, Site-Directed; Peroxidase; Spectrum Analysis, Raman | 1999 |
Levels of amino acid neurotransmitters during mouse cerebellar neurogenesis and in histotypic cerebellar cultures.
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebellum; Chromatography, High Pressure Liquid; Embryonic and Fetal Development; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Mice; Mice, Inbred Strains; Neurons; Neurotransmitter Agents; Taurine | 1999 |
Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Aspartic Acid; Binding Sites; Cattle; Crystallography, X-Ray; Glutamic Acid; HSP70 Heat-Shock Proteins; Kinetics; Peptide Fragments; Peptide Mapping; Point Mutation; Protein Conformation; Recombinant Proteins; Scattering, Radiation; Serine; Solutions; Spectrometry, Fluorescence; X-Rays | 1999 |
Effects of excitatory amino acids and nimodipine on calcium currents in cultured rat cortical neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Aspartic Acid; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acids; Glutamic Acid; Nimodipine; Rats; Rats, Wistar | 1999 |
Localization of acidic residues involved in the proton pumping activity of the bovine heart mitochondrial bc1 complex.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cattle; Dicyclohexylcarbodiimide; Electron Transport Complex III; Electrophoresis, Polyacrylamide Gel; Fluoresceins; Glutamic Acid; Iron-Sulfur Proteins; Mitochondria, Heart; Molecular Sequence Data; Protons; Quinolines; Sequence Analysis; Sequence Homology, Amino Acid | 1999 |
Rett syndrome: 1H spectroscopic imaging at 4.1 Tesla.
Topics: Aspartic Acid; Brain; Child; Child, Preschool; Creatine; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Reference Values; Rett Syndrome | 1999 |
Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method.
Topics: Algorithms; Animals; Aspartic Acid; Blood-Brain Barrier; Brain; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Microinjections; Rats; Rats, Wistar; Stereoisomerism | 1999 |
Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Extracellular Space; Female; Glutamic Acid; Hindlimb; Histidine; Locomotion; Microdialysis; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Spinal Cord | 1999 |
Effects of missense mutations Phe110Ile and Glu244Asp in human cardiac troponin T on force generation in skinned cardiac muscle fibers.
Topics: Animals; Aspartic Acid; Base Sequence; Calcium; Cardiomyopathy, Hypertrophic; DNA Primers; Glutamic Acid; Humans; Isoleucine; Male; Muscle Fibers, Skeletal; Mutation, Missense; Myocardium; Phenylalanine; Rabbits; Troponin T | 1999 |
Glutamate transport asymmetry and metabolism in the functioning kidney.
Topics: Animals; Aspartic Acid; Biological Transport; Glutamic Acid; Glutamine; In Vitro Techniques; Kidney; Male; Perfusion; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1999 |
Identification of catalytic residues of pepstatin-insensitive carboxyl proteinases from prokaryotes by site-directed mutagenesis.
Topics: Amino Acid Sequence; Aspartic Acid; Aspartic Acid Endopeptidases; Base Sequence; Catalytic Domain; Circular Dichroism; Cloning, Molecular; Conserved Sequence; Escherichia coli; Glutamic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Pepstatins; Polymerase Chain Reaction; Protein Conformation; Pseudomonas; Recombinant Proteins; Restriction Mapping; Sequence Alignment; Sequence Homology, Amino Acid; Xanthomonas | 1999 |
Role of the ADP/ATP and aspartate/glutamate antiporters in the uncoupling effect of fatty acids, lauryl sulfate, and 2, 4-dinitrophenol in liver mitochondria.
Topics: 2,4-Dinitrophenol; Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Carrier Proteins; Fatty Acids; Fatty Acids, Nonesterified; Glutamic Acid; Kinetics; Mitochondria, Liver; Mitochondrial ADP, ATP Translocases; Oxygen Consumption; Rats; Sodium Dodecyl Sulfate; Uncoupling Agents | 1999 |
Neurotoxicity of glutamate at the concentration released upon spinal cord injury.
Topics: Animals; Aspartic Acid; Contusions; Glutamic Acid; Male; Microdialysis; Nerve Degeneration; Neurotoxins; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries | 1999 |
Glucagon-like peptide-1 modulates neuronal activity in the rat's hippocampus.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Electroencephalography; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glutamic Acid; Glutamine; Hippocampus; Injections, Intraventricular; Male; Neurons; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Stimulation, Chemical; Ventromedial Hypothalamic Nucleus | 1999 |
Propionyl-IIGL tetrapeptide antagonizes beta-amyloid excitotoxicity in rat nucleus basalis.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Aspartic Acid; Avoidance Learning; Basal Nucleus of Meynert; Behavior, Animal; Extracellular Space; Glutamic Acid; Histocytochemistry; Male; Microdialysis; Motor Activity; Neuroprotective Agents; Oligopeptides; Peptide Fragments; Rats; Rats, Wistar; Taurine | 1999 |
Changes in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cord.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Citrulline; Glutamic Acid; Glycine; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Taurine; Threonine; Time Factors | 1999 |
Hydration change during the aging of phosphorylated human butyrylcholinesterase: importance of residues aspartate-70 and glutamate-197 in the water network as probed by hydrostatic and osmotic pressures.
Topics: Alkylation; Amino Acid Substitution; Aspartic Acid; Binding Sites; Butyrylcholinesterase; Computer Simulation; Enzyme Stability; Glutamic Acid; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrostatic Pressure; Kinetics; Models, Molecular; Osmolar Concentration; Phosphorylation; Protein Denaturation; Protein Structure, Quaternary; Recombinant Proteins; Soman; Thermodynamics; Water | 1999 |
The regulation of Na(+)-dependent anionic amino acid transport by the rat mammary gland.
Topics: Animals; Aspartic Acid; Biological Transport; Bromocriptine; Carrier Proteins; Female; Glutamic Acid; Lactation; Mammary Glands, Animal; Membrane Proteins; Pregnancy; Prolactin; Rats; Sodium; Symporters; Up-Regulation | 1999 |
Localization of L-glutamate and glutamate-like receptors at the squid giant synapse.
Topics: Alanine; Animals; Antibody Specificity; Aspartic Acid; Blotting, Western; Chromatography, High Pressure Liquid; Decapodiformes; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Ganglia, Invertebrate; Glutamic Acid; Glycine; Receptors, Glutamate; Serine; Synapses; Taurine | 1999 |
Dual photoactive species in Glu46Asp and Glu46Ala mutants of photoactive yellow protein: a pH-driven color transition.
Topics: Alanine; Aspartic Acid; Bacterial Proteins; Glutamic Acid; Half-Life; Halorhodospira halophila; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Photolysis; Photoreceptors, Microbial; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared | 1999 |
Amino acid efflux and cell volume regulation in cerebrocortical minislices prepared from chronically hyponatraemic and hypernatraemic rats.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amino Acids; Animals; Aspartic Acid; Biological Transport; Cell Size; Cerebral Cortex; Chronic Disease; Ethylmaleimide; gamma-Aminobutyric Acid; Glutamic Acid; Hypernatremia; Hyponatremia; Male; Osmotic Pressure; Rats; Rats, Wistar; Sodium; Trifluoperazine | 1999 |
Chronic haloperidol treatment impairs glutamate transport in the rat striatum.
Topics: Animals; Aspartic Acid; Biological Transport; Corpus Striatum; Dopamine Antagonists; Glutamic Acid; Haloperidol; Male; Rats; Rats, Wistar; Synaptosomes; Tritium | 1999 |
Molecular defects in variant forms of mannose-binding protein associated with immunodeficiency.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Aspartic Acid; Carrier Proteins; Collectins; Complement Fixation Tests; Cysteine; Disulfides; Glutamic Acid; Glycine; Humans; Immunologic Deficiency Syndromes; Mannans; Molecular Sequence Data; Point Mutation; Protein Processing, Post-Translational; Rats | 1999 |
Structure comparison between oxidized and reduced plastocyanin from a fern, Dryopteris crassirhizoma.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Chlorophyta; Copper; Crystallography, X-Ray; Cyanobacteria; Glutamic Acid; Models, Molecular; Molecular Sequence Data; Oxidation-Reduction; Plants; Plastocyanin; Protein Conformation; Protein Structure, Secondary; Species Specificity; Trees | 1999 |
Mutations in the rod outer segment membrane guanylate cyclase in a cone-rod dystrophy cause defects in calcium signaling.
Topics: Animals; Arginine; Aspartic Acid; Calcium Signaling; Calcium-Binding Proteins; Cattle; Cysteine; Enzyme Activation; Glutamic Acid; Guanylate Cyclase; Guanylate Cyclase-Activating Proteins; Humans; Mutagenesis, Insertional; Protein Binding; Receptors, Cell Surface; Retinal Degeneration; Rod Cell Outer Segment; S100 Proteins | 1999 |
Differential effects of haloperidol and clozapine on ionotropic glutamate receptors in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Aspartic Acid; Binding Sites; Brain; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1999 |
Substrate turnover by transporters curtails synaptic glutamate transients.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Benzothiadiazines; Cells, Cultured; Evoked Potentials; Glutamic Acid; Hippocampus; Membrane Potentials; N-Methylaspartate; Neuroglia; Neurons; Oocytes; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission; Xenopus laevis | 1999 |
Frontal lobe neuronal injury correlates to altered function in FIV-infected cats.
Topics: Animals; Aspartic Acid; Cats; CD4 Lymphocyte Count; Choline; Electroencephalography; Feline Acquired Immunodeficiency Syndrome; Frontal Lobe; Glutamic Acid; Glutamine; Immunodeficiency Virus, Feline; Magnetic Resonance Imaging; Neurons; Specific Pathogen-Free Organisms | 1999 |
Hyposmotically induced amino acid release from the rat cerebral cortex: role of phospholipases and protein kinases.
Topics: Acetophenones; Alanine; Amino Acids; Animals; Arachidonic Acids; Aspartic Acid; Brain Edema; Cerebral Cortex; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dimethyl Sulfoxide; Enzyme Inhibitors; Estrenes; Ethanolamines; Fatty Acids, Unsaturated; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hypotonic Solutions; Male; Osmotic Pressure; Phosphodiesterase Inhibitors; Phospholipases A; Phospholipases A2; Protein Kinase C; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Serine; Solvents; Taurine; Water-Electrolyte Balance | 1999 |
Excitatory amino acids and taurine levels in cerebrospinal fluid of hypoxic ischemic encephalopathy in newborn.
Topics: Aspartic Acid; Asphyxia Neonatorum; Case-Control Studies; Excitatory Amino Acids; Female; Follow-Up Studies; Glutamic Acid; Glycine; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Taurine | 1999 |
Effects of ammonia on the anaplerotic pathway and amino acid metabolism in the brain: an ex vivo 13C NMR spectroscopic study of rats after administering [2-13C]] glucose with or without ammonium acetate.
Topics: Acetates; Amino Acids; Ammonia; Animals; Aspartic Acid; Brain; Carbon Isotopes; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Kinetics; Magnetic Resonance Spectroscopy; Male; Models, Chemical; Models, Neurological; Neuroglia; Neurons; Pyruvate Carboxylase; Rats; Rats, Sprague-Dawley; Time Factors | 1999 |
Glutamate-containing parenteral nutrition doubles plasma glutamate: a risk factor in neurosurgical patients with blood-brain barrier damage?
Topics: Asparagine; Aspartic Acid; Blood-Brain Barrier; Brain Edema; Chromatography, High Pressure Liquid; Craniotomy; Female; Glutamic Acid; Glutamine; Hospitals, University; Humans; Intensive Care Units; Male; Middle Aged; Parenteral Nutrition; Prospective Studies; Risk Factors; Treatment Outcome | 1999 |
Studies on amino acid metabolism in the brain using 15N-labeled precursors.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Glutamine; Guinea Pigs; In Vitro Techniques; Kinetics; Nitrogen Isotopes; Potassium | 1999 |
Amino acids as osmolytes in the retina.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amino Acids; Animals; Aspartic Acid; Cell Size; Chickens; Chloride Channels; gamma-Aminobutyric Acid; Glutamic Acid; Nitrobenzoates; Osmolar Concentration; Osmosis; Potassium Chloride; Retina; Tamoxifen; Taurine | 1999 |
The aspartate aminotransferase-catalysed exchange of the alpha-protons of aspartate and glutamate: the effects of the R386A and R292V mutations on this exchange reaction.
Topics: Aspartate Aminotransferases; Aspartic Acid; Deuterium; Glutamic Acid; Glycine Hydroxymethyltransferase; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Mutation; Protons; Stereoisomerism; Tryptophan Synthase | 1999 |
Investigating site-specific effects of the -X glutamate in a parvalbumin CD site model peptide.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid; Binding Sites; Calcium; Carps; Cattle; Circular Dichroism; Dimerization; Glutamic Acid; In Vitro Techniques; Kinetics; Molecular Sequence Data; Parvalbumins; Peptide Fragments; Protein Structure, Quaternary; Rats; Thermodynamics | 1999 |
Hypothermia decreases excitatory neurotransmitter release in bacterial meningitis in rabbits.
Topics: Animals; Aspartic Acid; Excitatory Amino Acids; Glutamic Acid; HSP70 Heat-Shock Proteins; Hypothermia, Induced; Male; Meningitis, Bacterial; Rabbits | 1999 |
Reciprocal effects of substitutions at the subunit interfaces in hexameric pyrophosphatase of Escherichia coli. Dimeric and monomeric forms of the enzyme.
Topics: Amino Acid Substitution; Aspartic Acid; Catalysis; Crystallography, X-Ray; Dimerization; Enzyme Stability; Escherichia coli; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Magnesium Compounds; Protein Structure, Quaternary; Pyrophosphatases; Substrate Specificity; Temperature; Tyrosine | 1999 |
Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transporters.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Binding, Competitive; Biological Transport; Carrier Proteins; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; In Vitro Techniques; Models, Molecular; Neuroglia; Oocytes; Prosencephalon; Protein Isoforms; Rats; Receptors, Neurotransmitter; Symporters; Synaptosomes; Tritium; Xenopus laevis | 1999 |
Selectivity of the polyspecific cation transporter rOCT1 is changed by mutation of aspartate 475 to glutamate.
Topics: Amino Acid Substitution; Animals; Arginine; Aspartic Acid; Carrier Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Ion Transport; Membrane Proteins; Mutagenesis, Site-Directed; Organic Cation Transporter 1; Quaternary Ammonium Compounds; Tetraethylammonium; Xenopus laevis | 1999 |
On-line derivatization for continuous and automatic monitoring of brain extracellular glutamate levels in anesthetized rats: a microdialysis study.
Topics: Anesthesia; Animals; Aspartic Acid; Autoanalysis; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Male; Microdialysis; o-Phthalaldehyde; Rats; Rats, Sprague-Dawley; Taurine; Vasospasm, Intracranial | 1999 |
The Corynebacterium glutamicum insertion sequence ISCg2 prefers conserved target sequences located adjacent to genes involved in aspartate and glutamate metabolism.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Consensus Sequence; Conserved Sequence; Corynebacterium; DNA Transposable Elements; Genes, Bacterial; Genome, Bacterial; Glutamic Acid; Molecular Sequence Data; Mutagenesis, Insertional; Recombination, Genetic; Restriction Mapping; Sequence Homology, Amino Acid | 1999 |
Mutations of endo-beta-N-acetylglucosaminidase H active site residueAs sp130 anG glu132: activities and conformations.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Glutamic Acid; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Secondary | 1999 |
Immuno-, phagocytosis-modulating and antitoxic properties of dipeptides are defined by the activity of their constituent amino acids.
Topics: Amino Acids; Animals; Antidotes; Aspartic Acid; Benzene; Dipeptides; Glutamic Acid; Granulocytes; Immune System; Male; Methionine; Mice; Mice, Inbred CBA; Phagocytosis; Rabbits; T-Lymphocytes; Tryptophan | 1999 |
The ontogeny of glutamate receptors and D-aspartate binding sites in the ovine CNS.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Embryonic and Fetal Development; Fetus; Glutamic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Sheep | 1999 |
Nicotine stimulation of extracellular glutamate levels in the nucleus accumbens: neuropharmacological characterization.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Denervation; Dicarboxylic Acids; Dopamine; Extracellular Space; Glutamic Acid; Haloperidol; Kainic Acid; Kinetics; Male; Mecamylamine; Microdialysis; Neurotransmitter Uptake Inhibitors; Nicotine; Nucleus Accumbens; Oxidopamine; Pyrrolidines; Rats; Rats, Sprague-Dawley | 2000 |
Compensatory change in EAAC1 glutamate transporter in rat hippocampus CA1 region during kindling epileptogenesis.
Topics: Adaptation, Physiological; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Carrier Proteins; Dicarboxylic Acids; Epilepsy; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Extracellular Space; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hippocampus; Immunoblotting; Kindling, Neurologic; Microdialysis; Pyrrolidines; Rats; Rats, Wistar; Symporters | 1999 |
Deficits of NMDA receptors and glutamate uptake sites in the frontal cortex in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; Aminoquinolines; Aspartic Acid; Binding Sites; Excitatory Amino Acid Antagonists; Frontal Lobe; Glutamic Acid; Humans; Kinetics; Matched-Pair Analysis; Receptors, N-Methyl-D-Aspartate; Thermodynamics | 1999 |
Binding of 2-naphthols to D38E mutants of 3-oxo-Delta 5-steroid isomerase: variation of ligand ionization state with the nature of the electrophilic component.
Topics: Aspartic Acid; Binding Sites; Comamonas testosteroni; Enzyme Inhibitors; Equilenin; Glutamic Acid; Kinetics; Ligands; Mutagenesis, Site-Directed; Naphthols; Spectrophotometry, Ultraviolet; Steroid Isomerases | 2000 |
SNARE protein-dependent glutamate release from astrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Anti-Bacterial Agents; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Botulinum Toxins; Botulinum Toxins, Type A; Calcium; Cells, Cultured; Coculture Techniques; Dicarboxylic Acids; Enzyme Inhibitors; Glutamic Acid; Hippocampus; Kainic Acid; Macrolides; Membrane Potentials; Membrane Proteins; Nerve Tissue Proteins; Neurons; Proton-Translocating ATPases; Pyrrolidines; Rats; SNARE Proteins; Vesicular Transport Proteins | 2000 |
A membrane-embedded glutamate is required for ligand binding to the multidrug transporter EmrE.
Topics: Amino Acid Sequence; Antiporters; Aspartic Acid; Bacterial Proteins; Binding Sites; Biological Transport; Carrier Proteins; Cell Membrane; Conserved Sequence; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Indicators and Reagents; Kinetics; Membrane Proteins; Molecular Sequence Data; Onium Compounds; Organophosphorus Compounds; Recombinant Proteins | 2000 |
Release of classical transmitters and nitric oxide in the rat olfactory bulb, evoked by vaginocervical stimulation and potassium, varies with the oestrus cycle.
Topics: Animals; Aspartic Acid; Cervix Uteri; Citrulline; Dopamine; Estrus; Female; gamma-Aminobutyric Acid; Glutamic Acid; Homovanillic Acid; Hydroxyindoleacetic Acid; Microdialysis; Neurotransmitter Agents; Nitric Oxide; Norepinephrine; Olfactory Bulb; Ovariectomy; Peripheral Nerves; Physical Stimulation; Potassium Chloride; Rats; Rats, Wistar; Vagina; Vagotomy; Vagus Nerve; Wakefulness | 2000 |
Asp-99 donates a hydrogen bond not to Tyr-14 but to the steroid directly in the catalytic mechanism of Delta 5-3-ketosteroid isomerase from Pseudomonas putida biotype B.
Topics: Asparagine; Aspartic Acid; Binding Sites; Catalysis; Equilenin; Glutamic Acid; Hydrogen Bonding; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; Nandrolone; Pseudomonas putida; Steroid Isomerases; Tyrosine | 2000 |
Origins of deuterium kinetic isotope effects on the proton transfers of the bacteriorhodopsin photocycle.
Topics: Arginine; Aspartic Acid; Bacteriorhodopsins; Deuterium Oxide; Glutamic Acid; Halobacterium salinarum; Kinetics; Mutagenesis, Site-Directed; Photolysis; Protons; Purple Membrane; Tyrosine; Water | 2000 |
In vitro proton and phosphorus NMR spectroscopic analysis of murine (C57Bl/6J) brain development.
Topics: Aging; Animals; Aspartic Acid; Brain; Brain Chemistry; Chloroform; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Magnetic Resonance Spectroscopy; Methanol; Mice; Mice, Inbred C57BL; Phosphatidylcholines; Phosphatidylinositols; Phosphorus; Protons; Taurine | 1999 |
Neuronal pyruvate carboxylation supports formation of transmitter glutamate.
Topics: Animals; Aspartic Acid; Astrocytes; Bicarbonates; Carbon Radioisotopes; Cells, Cultured; Cerebellum; Citrate (si)-Synthase; Citric Acid Cycle; Fumarate Hydratase; Glutamic Acid; Ketoglutarate Dehydrogenase Complex; Malate Dehydrogenase; Neurons; Neurotoxins; Nitro Compounds; Propionates; Pyruvates; Rats | 2000 |
Selectively 2H-labeled Glu/Asp: application to pKa measurements in Abeta amyloid peptides.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Deuterium; Glutamic Acid; Histidine; Isotope Labeling; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptide Fragments; Protein Conformation | 2000 |
Antisense knockdown of GLAST, a glial glutamate transporter, compromises retinal function.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Electroretinography; Female; Glutamic Acid; Immunoenzyme Techniques; Neuroglia; Oligonucleotides, Antisense; Rats; Rats, Wistar; Retina | 2000 |
Mitochondrial compartmentation at the cellular level: astrocytes and neurons.
Topics: Acetates; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Citric Acid Cycle; Glucose; Glutamic Acid; Glutamine; Mitochondria; Models, Chemical; Neurons | 1999 |
Transient treatments with L-glutamate and threo-beta-hydroxyaspartate induce swelling of rat cultured astrocytes.
Topics: 3-O-Methylglucose; Animals; Aspartic Acid; Astrocytes; Cell Nucleus; Cell Size; Cells, Cultured; Cytoplasm; Glutamic Acid; Kinetics; Quisqualic Acid; Rats; Rats, Inbred WKY | 2000 |
Mutational, kinetic, and NMR studies of the roles of conserved glutamate residues and of lysine-39 in the mechanism of the MutT pyrophosphohydrolase.
Topics: Adenosine Triphosphate; Aspartic Acid; Bacterial Proteins; Binding, Competitive; Catalysis; Chlorides; Conserved Sequence; DNA Mutational Analysis; Escherichia coli Proteins; Glutamic Acid; Glutamine; Kinetics; Lysine; Magnesium; Magnesium Chloride; Manganese; Manganese Compounds; Mutagenesis, Site-Directed; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Phosphoric Monoester Hydrolases; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protons; Pyrophosphatases; Recombinant Proteins; Solvents | 2000 |
Control of synaptic depression by glutamate transporters.
Topics: Action Potentials; Alanine Transaminase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Anti-Bacterial Agents; Antihypertensive Agents; Aspartic Acid; ATP-Binding Cassette Transporters; Benzothiadiazines; Chick Embryo; Cochlear Nucleus; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neural Inhibition; Neuronal Plasticity; Receptors, AMPA; Synaptic Transmission | 2000 |
Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study.
Topics: Adult; Aged; Aspartic Acid; Choline; Creatine; Depressive Disorder, Major; Female; Frontal Lobe; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Myo-Inositol-1-Phosphate Synthase; Severity of Illness Index | 2000 |
Metabolite anion carriers mediate the uptake of the anionic drug fluorescein in renal cortical mitochondria.
Topics: Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Fluorescein; Glutamic Acid; Ketoglutaric Acids; Kidney Cortex; Mitochondria; Rats; Succinates; Tricarboxylic Acids; Valproic Acid | 2000 |
Presence of 2-furoylmethyl derivatives in hydrolysates of processed tomato products.
Topics: Alanine; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Freeze Drying; Furans; gamma-Aminobutyric Acid; Glutamic Acid; Hydrolysis; Lysine; Maillard Reaction; Serine; Solanum lycopersicum; Threonine | 2000 |
Slow formation of [3Fe-4S](1+) clusters in mutant forms of Desulfovibrio africanus ferredoxin III.
Topics: Amino Acid Substitution; Aspartic Acid; Desulfovibrio; Electron Spin Resonance Spectroscopy; Ferredoxins; Genetic Variation; Glutamic Acid; Histidine; Iron-Sulfur Proteins; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Recombinant Proteins; Spectrophotometry | 2000 |
Probing the mechanistic role of glutamate residue in the zinc-binding motif of type A botulinum neurotoxin light chain.
Topics: Amino Acid Motifs; Aspartic Acid; Botulinum Toxins, Type A; Circular Dichroism; Energy Transfer; Enzyme Activation; Glutamic Acid; Glutamine; Kinetics; Metalloendopeptidases; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Secondary; Spectrometry, Fluorescence; Substrate Specificity; Zinc | 2000 |
Glutamate transport blockade has a differential effect on AMPA and NMDA receptor-mediated synaptic transmission in the developing barrel cortex.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Benzothiadiazines; Biological Transport; Dicarboxylic Acids; Diuretics; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Neurotransmitter Uptake Inhibitors; Picrotoxin; Pyrrolidines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium Chloride Symporter Inhibitors; Somatosensory Cortex; Synaptic Transmission; Thalamus | 2000 |
Solution structure of the sixth LDL-A module of the LDL receptor.
Topics: Amino Acid Sequence; Aspartic Acid; Calcium; Crystallography, X-Ray; Glutamic Acid; Humans; Hyperlipoproteinemia Type II; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Protein Folding; Receptors, LDL; Solutions | 2000 |
Selective high-affinity transport of aspartate by a Drosophila homologue of the excitatory amino-acid transporters.
Topics: Animals; Aspartic Acid; Biological Transport; Drosophila melanogaster; Excitatory Amino Acid Transporter 2; Glutamic Acid; Potassium; Receptors, Neurotransmitter; Sodium | 2000 |
Levels of amino acid neurotransmitters during mouse olfactory bulb neurogenesis and in histotypic olfactory bulb cultures.
Topics: Age Factors; Animals; Aspartic Acid; Cells, Cultured; Fetus; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Mice; Mice, Inbred Strains; Microscopy, Electron; Neurons; Neuropil; Neurotransmitter Agents; Olfactory Bulb; Synapses; Taurine | 2000 |
Effects of betaxolol on light responses and membrane conductance in retinal ganglion cells.
Topics: Adrenergic beta-Antagonists; Ambystoma; Animals; Aspartic Acid; Betaxolol; Calcium; Electroretinography; Glutamic Acid; Light; Membrane Potentials; Patch-Clamp Techniques; Photic Stimulation; Retina; Retinal Ganglion Cells; Sodium | 2000 |
Cerebral oligaemia episode triggers free radical formation and late cognitive deficiencies.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Carotid Stenosis; Cognition Disorders; Corpus Striatum; Disease Models, Animal; Dopamine; Escape Reaction; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Homovanillic Acid; Hydroxybenzoates; Hydroxyl Radical; Ischemic Attack, Transient; Learning Disabilities; Male; Maze Learning; Memory Disorders; Microdialysis; Oxidative Stress; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Reperfusion Injury; Spatial Behavior; Swimming; Time Factors | 2000 |
Features of contralaterally evoked inhibition in the inferior colliculus.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Bicuculline; Chiroptera; Evoked Potentials, Auditory; GABA Antagonists; Glutamic Acid; Inferior Colliculi; Iontophoresis; Receptors, GABA-A; Strychnine | 2000 |
The major surface antigens of Entamoeba histolytica trophozoites are GPI-anchored proteophosphoglycans.
Topics: Animals; Antigens, Protozoan; Antigens, Surface; Aspartic Acid; Carbohydrate Conformation; Disaccharides; Entamoeba histolytica; Glutamic Acid; Glycosylphosphatidylinositols; Hexoses; Hydrofluoric Acid; Hydrogen-Ion Concentration; Hydrolysis; Inositol; Inositol Phosphates; Methylation; Molecular Weight; Peptides; Phosphorylation; Phosphoserine; Polysaccharides; Trifluoroacetic Acid; Virulence | 2000 |
Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298.
Topics: Animals; Aorta; Aspartic Acid; Cardiovascular Diseases; Cells, Cultured; COS Cells; Genotype; Glutamic Acid; Humans; Immunoblotting; Isoenzymes; Lung Diseases; Mutagenesis, Site-Directed; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Plasmids; Polymorphism, Genetic; Transfection | 2000 |
Topical glucose and accumulation of excitotoxic and other amino acids in ischemic cerebral cortex.
Topics: Animals; Aspartic Acid; Blood Pressure; Brain Ischemia; Carbon Dioxide; Cerebral Cortex; Ethanolamines; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Hyperglycemia; Male; Oxygen; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Taurine | 2000 |
An engineered blockage within the ammonia tunnel of carbamoyl phosphate synthetase prevents the use of glutamine as a substrate but not ammonia.
Topics: Alanine; Ammonia; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbamyl Phosphate; Escherichia coli; Glutamic Acid; Glutamine; Glycine; Kinetics; Lysine; Methionine; Mutagenesis, Site-Directed; Phenylalanine; Serine; Substrate Specificity; Time Factors | 2000 |
Site-directed mutagenesis identifies residues in uncoupling protein (UCP1) involved in three different functions.
Topics: Adipose Tissue, Brown; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Binding Sites; Carrier Proteins; Chlorides; Cricetinae; Electron Transport; Glutamic Acid; Glutamine; Guanosine Triphosphate; Ion Channels; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Mutagenesis, Site-Directed; Protons; Saccharomyces cerevisiae; Uncoupling Agents; Uncoupling Protein 1 | 2000 |
Novel peak assignments of in vivo (13)C MRS in human brain at 1.5 T.
Topics: Adult; Aspartic Acid; Bicarbonates; Brain; Carbon Isotopes; Child, Preschool; Creatine; Demyelinating Diseases; Electron Spin Resonance Spectroscopy; Female; Glucose; Glutamic Acid; Glutamine; Humans; Infusions, Intravenous; Inositol; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Taurine | 2000 |
Acidosis and astrocyte amino acid metabolism.
Topics: Acidosis; Amino Acids; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Oxidation-Reduction; Rats | 2000 |
Fourier transform infrared evidence for early deprotonation of Asp(85) at alkaline pH in the photocycle of bacteriorhodopsin mutants containing E194Q.
Topics: Amino Acid Substitution; Aspartic Acid; Bacteriorhodopsins; Biophysical Phenomena; Biophysics; Glutamic Acid; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Photochemistry; Protons; Spectroscopy, Fourier Transform Infrared | 2000 |
Analysis of affinity and specificity in an EF-hand site using double mutant cycles.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Calcium; Chickens; EF Hand Motifs; Energy Metabolism; Glutamic Acid; Magnesium; Molecular Sequence Data; Mutagenesis, Site-Directed; Myosin Light Chains; Thermodynamics | 2000 |
Investigation of spectroscopic intermediates during copper-binding and TPQ formation in wild-type and active-site mutants of a copper-containing amine oxidase from yeast.
Topics: Amine Oxidase (Copper-Containing); Asparagine; Aspartic Acid; Binding Sites; Coenzymes; Copper; Cysteine; Dihydroxyphenylalanine; Glutamic Acid; Glutamine; Histidine; Mutagenesis, Site-Directed; Oxygen Consumption; Pichia; Recombinant Proteins; Spectrophotometry, Atomic; Spectrophotometry, Ultraviolet | 2000 |
Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Cerebral Cortex; Extracellular Space; Gene Expression Regulation, Enzymologic; Glutamic Acid; Humans; Hydroxyindoleacetic Acid; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Microdialysis; Phenotype; Superoxide Dismutase | 2000 |
Mechanism of Ca2+-induced inhibition of Escherichia coli inorganic pyrophosphatase.
Topics: Alanine; Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Calcium; Dialysis; Diphosphates; Escherichia coli; Glutamic Acid; Hydrolysis; Inorganic Pyrophosphatase; Kinetics; Lanthanum; Magnesium Compounds; Models, Molecular; Pyrophosphatases | 2000 |
Excitatory amino acid profiles of synovial fluid from patients with arthritis.
Topics: Adolescent; Adult; Aged; Arthritis; Arthritis, Reactive; Aspartic Acid; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cohort Studies; Excitatory Amino Acids; Glutamic Acid; Humans; Joint Diseases; Lupus Erythematosus, Systemic; Middle Aged; Reference Values; Synovial Fluid; Synovitis | 2000 |
Calf intestinal mucin: isolation, partial characterization, and measurement in ileal digesta with an enzyme-linked immunosorbent assay.
Topics: Abomasum; Animals; Antibody Specificity; Aspartic Acid; Carbohydrates; Cattle; Centrifugation, Density Gradient; Cesium; Chlorides; Diet; Digestion; Enzyme-Linked Immunosorbent Assay; Glutamic Acid; Ileum; Immune Sera; Intestines; Milk; Mucins; Serine; Threonine | 2000 |
Two acidic amino acid residues, Asp(470) and Glu(471), contained in the carboxyl cytoplasmic tail of a major lysosomal membrane protein, LGP85/LIMP II, are important for its accumulation in secondary lysosomes.
Topics: Animals; Aspartic Acid; Base Sequence; CD36 Antigens; Cytoplasm; DNA Primers; Glutamic Acid; Humans; Lysosomal Membrane Proteins; Lysosomes; Membrane Glycoproteins; Membrane Proteins; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Receptors, Scavenger; Sialoglycoproteins; Subcellular Fractions; Tumor Cells, Cultured | 2000 |
Kinetic and pharmacological analysis of L-[35S]cystine transport into rat brain synaptosomes.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Brain; Cystine; Glutamic Acid; In Vitro Techniques; Kinetics; Rats; Rats, Wistar; Sodium; Sulfur Radioisotopes; Synaptosomes; Tritium | 2000 |
Differential effect of beta-N-oxalylamino-L-alanine, the Lathyrus sativus neurotoxin, and (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate on the excitatory amino acid and taurine levels in the brain of freely moving rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; Aspartic Acid; beta-Alanine; Brain; Corpus Striatum; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Male; Microdialysis; Motor Cortex; Potassium; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Taurine; Tetrodotoxin | 2000 |
The Na+-dependent glutamate and aspartate transporter supports glutathione maintenance and survival of CHO-K1 cells.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Benzoquinones; Cell Division; Cell Survival; CHO Cells; Cisplatin; Cricetinae; Culture Media; Drug Resistance; Genotype; Glutamic Acid; Glutamine; Glutathione; Hydrogen-Ion Concentration; Mutation; Oxidative Stress; Sodium | 1998 |
Elevated glutamate levels in the vitreous body of an in vivo model of optic nerve ischemia.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Disease Models, Animal; Endothelin-1; Glutamic Acid; Glycine; Infusion Pumps, Implantable; Male; Optic Nerve; Optic Neuropathy, Ischemic; Rabbits; Vitreous Body | 2000 |
A carboxylate triad is essential for the polymerase activity of Escherichia coli DNA polymerase I (Klenow fragment). Presence of two functional triads at the catalytic center.
Topics: Alanine; Aspartic Acid; Binding Sites; Catalysis; DNA; DNA Polymerase I; Dose-Response Relationship, Drug; Escherichia coli; Glutamic Acid; Kinetics; Magnesium; Mutagenesis, Site-Directed; Phosphoric Acids; Plasmids; Sodium Chloride; Transfection; Trichloroacetic Acid | 2000 |
Effects of aluminum exposure on glutamate metabolism: a possible explanation for its toxicity.
Topics: Aluminum; Animals; Aspartic Acid; Astrocytes; Brain; Cell Extracts; Cells, Cultured; Dose-Response Relationship, Drug; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Inhibitory Concentration 50; L-Lactate Dehydrogenase; Liver; Organ Specificity; Rats | 2000 |
A novel missense mutation (D110E) in exon 4 of CFTR (ABCC7) in a CF infant presenting with hypochloraemic metabolic alkalosis.
Topics: Alkalosis; Amino Acid Substitution; Aspartic Acid; Child, Preschool; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Glutamic Acid; Humans; Infant; Infant, Newborn; Male; Mutation, Missense | 2000 |
Enhancement of glutamate uptake transport by CO(2)/bicarbonate in the leech giant glial cell.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Aspartic Acid; Bicarbonates; Biological Transport; Carbon Dioxide; Carrier Proteins; Ganglia, Invertebrate; Glutamic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Intracellular Fluid; Leeches; Membrane Potentials; Neuroglia; Patch-Clamp Techniques; Receptors, Neurotransmitter; Sodium; Sodium-Bicarbonate Symporters | 2000 |
Na+-dependent high-affinity glutamate transport in macrophages.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Binding, Competitive; Carrier Proteins; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutathione; Humans; Intracellular Fluid; Ion Transport; Macaca fascicularis; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Monocytes; Pyrrolidines; Sodium; Symporters; Tumor Necrosis Factor-alpha | 2000 |
BDNF rapidly induces aspartate release from cultured CNS neurons.
Topics: Animals; Animals, Newborn; Aspartic Acid; Brain-Derived Neurotrophic Factor; Calcium; Cells, Cultured; Cerebellar Cortex; Cerebral Cortex; Glutamic Acid; Hippocampus; Immunohistochemistry; Intracellular Fluid; Microtubule-Associated Proteins; Neostriatum; Neurons; Rats; Receptor, trkB; Time Factors | 2000 |
Synaptically released glutamate does not overwhelm transporters on hippocampal astrocytes during high-frequency stimulation.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Biological Transport; Cells, Cultured; Drug Synergism; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Patch-Clamp Techniques; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Synapses; Synaptic Transmission; Theophylline | 2000 |
Acute decrease in net glutamate uptake during energy deprivation.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Brain Ischemia; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kinetics; Membrane Potentials; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Organ Culture Techniques; Patch-Clamp Techniques; Pyrrolidines; Quinoxalines; Rats | 2000 |
[Dopamine-dependent inhibition of glycine release in the rat nucleus accumbens during feeding].
Topics: Animals; Aspartic Acid; Calcium Channel Blockers; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Feeding Behavior; Glutamic Acid; Glycine; Male; Nucleus Accumbens; Raclopride; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 2000 |
Deterministic features of side-chain main-chain hydrogen bonds in globular protein structures.
Topics: Amino Acids; Asparagine; Aspartic Acid; Crystallization; Glutamic Acid; Glutamine; Histidine; Hydrogen Bonding; Protein Conformation; Protein Structure, Secondary; Proteins; Serine; Threonine | 2000 |
Mutational analyses of restriction endonuclease-HindIII mutant E86K with higher activity and altered specificity.
Topics: Aspartic Acid; Binding Sites; Cations, Divalent; Circular Dichroism; Deoxyribonuclease HindIII; DNA Mutational Analysis; DNA, Bacterial; Enzyme Activation; Glutamic Acid; Lysine; Mutagenesis, Site-Directed; Plasmids; Polymerase Chain Reaction; Recombinant Proteins; Substrate Specificity | 2000 |
Function of conserved acidic residues in the PSST homologue of complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica.
Topics: Amino Acid Sequence; Aspartic Acid; Conserved Sequence; Electron Spin Resonance Spectroscopy; Glutamic Acid; Hydrogenase; Intracellular Membranes; Iron-Sulfur Proteins; Kinetics; Ligands; Mitochondria; Models, Molecular; Mutagenesis, Site-Directed; NADH Dehydrogenase; Proton Pumps; Saccharomycetales; Sequence Analysis, Protein; Sequence Deletion; Ubiquinone | 2000 |
Spinal cord protection: effect of N-methyl-D-aspartate receptor antagonist MK-801 for spinal cord ischemia in a rabbit model.
Topics: Animals; Aspartic Acid; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Ischemia; Rabbits; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2000 |
Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65.
Topics: Age Factors; Aggression; Animals; Anxiety; Aspartic Acid; Brain; Brain Chemistry; Circadian Rhythm; Electroencephalography; Emotions; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Isoenzymes; Male; Mice; Mice, Knockout; Neurons; Neurotransmitter Agents; Seizures; Survival Rate | 2000 |
Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations.
Topics: Aspartic Acid; Basal Ganglia; Bipolar Disorder; Child; Choline; Creatine; Energy Metabolism; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Lipid Metabolism; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Reference Values; Temporal Lobe | 2000 |
Modeling the effects of mutations on the free energy of the first electron transfer from QA- to QB in photosynthetic reaction centers.
Topics: Alanine; Arginine; Asparagine; Aspartic Acid; Electron Transport; Energy Transfer; Glutamic Acid; Glutamine; Leucine; Models, Chemical; Mutagenesis, Site-Directed; Photosynthetic Reaction Center Complex Proteins; Quinones; Rhodobacter capsulatus; Rhodobacter sphaeroides; Static Electricity; Thermodynamics; Water | 2000 |
Hippocampal pathology in schizophrenia: magnetic resonance imaging and spectroscopy studies.
Topics: Adult; Aspartic Acid; Case-Control Studies; Dominance, Cerebral; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Schizophrenia | 2000 |
Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities.
Topics: Amino Acid Sequence; Anti-HIV Agents; Antibodies, Monoclonal; Aspartic Acid; Binding Sites; Binding, Competitive; Chemokine CXCL12; Chemokines, CXC; Glutamic Acid; HIV Envelope Protein gp120; HIV-1; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Receptors, CXCR4; Recombinant Proteins; Signal Transduction; Static Electricity; Tyrosine | 2000 |
The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM.
Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Apoptosis; Aspartic Acid; Caspases; Drosophila; Drosophila Proteins; Glutamic Acid; Hydrolysis; Inhibitor of Apoptosis Proteins; Insect Proteins; Molecular Sequence Data; Neuropeptides; Sequence Homology, Amino Acid | 2000 |
Regulation of high-affinity glutamate uptake activity in Bergmann glia cells by glutamate.
Topics: Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Cells, Cultured; Cerebellar Cortex; Chick Embryo; Glutamic Acid; Neuroglia; Protein Kinase C; Receptors, Glutamate; Tritium | 2000 |
Sampling extracellular aspartate, glutamate and gamma-aminobutyric acid in striate cortex of awake cat by in vivo microdialysis: surgical and methodological aspects.
Topics: Animals; Aspartic Acid; Cats; Extracellular Space; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Visual Cortex; Wakefulness | 2000 |
Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats.
Topics: Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Picrotoxin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures | 2000 |
Identification of key amino acid residues in Neisseria polysaccharea amylosucrase.
Topics: Amino Acid Sequence; Amino Acids; Aspartic Acid; Base Sequence; Binding Sites; Catalysis; Glucosyltransferases; Glutamic Acid; Histidine; Molecular Sequence Data; Mutagenesis, Site-Directed; Neisseria; Sequence Alignment; Structure-Activity Relationship | 2000 |
Uptake and metabolism of glutamate at non-synaptic regions of crayfish central nerve fibers: implications for axon-glia signaling.
Topics: Animals; Aspartic Acid; Astacoidea; Attention; Axons; Body Temperature; Excitatory Amino Acid Agonists; Ganglia, Invertebrate; Glutamic Acid; Inulin; Neuroglia; Signal Transduction; Sodium; Time Factors; Tritium | 2000 |
Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex: studies with DL-threo-beta-benzyloxyaspartate.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Brain Ischemia; Cerebral Cortex; Glutamic Acid; Hydrogen-Ion Concentration; Lactic Acid; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Taurine | 2000 |
The supramammillo-hippocampal and supramammillo-septal glutamatergic/aspartatergic projections in the rat: a combined [3H]D-aspartate autoradiographic and immunohistochemical study.
Topics: Animals; Aspartic Acid; Autoradiography; Efferent Pathways; Glutamic Acid; Hippocampus; Hypothalamus; Immunohistochemistry; Male; Neurons; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Septum of Brain; Tritium | 2000 |
Effects of ammonia on pentylenetetrazole-induced seizure threshold.
Topics: Ammonia; Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Hepatic Encephalopathy; Linear Models; Male; Neurons; Pentylenetetrazole; Rats; Rats, Wistar; Seizures | 1999 |
Amino acids in spinal dorsal horn of patients during surgery for neuropathic pain or spasticity.
Topics: Amino Acids; Aspartic Acid; Chromatography, High Pressure Liquid; Extracellular Space; Feasibility Studies; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Intraoperative Period; Microdialysis; Muscle Spasticity; Neuralgia; Peripheral Nervous System Diseases; Spinal Cord | 2000 |
The evaluation of the potential of botulinum C3 enzyme as an exogenous differentiation inducing factor to neurons.
Topics: Acetylcholine; ADP Ribose Transferases; Aniline Compounds; Animals; Antibodies, Monoclonal; Aspartic Acid; Botulinum Toxins; Calcium; Cell Differentiation; Excitatory Amino Acid Agonists; Fluorescent Dyes; gamma-Aminobutyric Acid; Glutamic Acid; Image Processing, Computer-Assisted; Immunohistochemistry; Kainic Acid; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Muscarine; Muscarinic Agonists; Neurons; Potassium; Xanthenes | 2000 |
Identification of a glutamic acid and an aspartic acid residue essential for catalytic activity of aspergillopepsin II, a non-pepsin type acid proteinase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Aspartic Acid Endopeptidases; Catalytic Domain; Circular Dichroism; Glutamic Acid; Hydrogen-Ion Concentration; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Protein Folding; Recombinant Proteins; Structure-Activity Relationship | 2000 |
Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro.
Topics: Animals; Aspartic Acid; Autoreceptors; Benzoates; Calcium; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; In Vitro Techniques; Indans; Male; Neurons; Phenylacetates; Prosencephalon; Quisqualic Acid; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Tetrodotoxin; Tritium | 2000 |
Novel structural determinants of mu-conotoxin (GIIIB) block in rat skeletal muscle (mu1) Na+ channels.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Binding Sites; Cell Line; Conotoxins; Ethyl Methanesulfonate; Glutamic Acid; Humans; Kinetics; Mesylates; Models, Molecular; Muscle, Skeletal; Mutagenesis, Site-Directed; Protein Structure, Secondary; Rats; Sodium Channel Blockers; Sodium Channels; Transfection | 2000 |
Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Bacillus; Binding Sites; Catalysis; Crystallography, X-Ray; Disaccharides; Glutamic Acid; Glycoside Hydrolases; Glycosylation; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Mass Spectrometry; Models, Chemical; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protons; Static Electricity; Structure-Activity Relationship; Xylan Endo-1,3-beta-Xylosidase; Xylosidases | 2000 |
Entry of R5X4 and X4 human immunodeficiency virus type 1 strains is mediated by negatively charged and tyrosine residues in the amino-terminal domain and the second extracellular loop of CXCR4.
Topics: Amino Acid Sequence; Aspartic Acid; Glutamic Acid; HIV-1; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Receptors, CXCR4; Tyrosine | 2000 |
Dietary arginine requirement of juvenile red drum (Sciaenops ocellatus) based on weight gain and feed efficiency.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Aquaculture; Arginine; Aspartic Acid; Citrulline; Energy Intake; Fishes; Glutamic Acid; Glycine; Nutritional Requirements; Ornithine; Weight Gain | 2000 |
Isinglass/collagen: denaturation and functionality.
Topics: Air Sacs; Animals; Arginine; Aspartic Acid; Calcium; Calorimetry, Differential Scanning; Cattle; Chelating Agents; Collagen; Decarboxylation; Detergents; Fishes; Gelatin; Glutamic Acid; Hydrogen-Ion Concentration; Hydroxyproline; Lysine; Molecular Weight; Monosaccharides; N-Acetylneuraminic Acid; Osmolar Concentration; Protein Denaturation; Saccharomyces cerevisiae; Temperature | 2000 |
Involvement of conserved aspartate and glutamate residues in the catalysis and substrate binding of maize starch synthase.
Topics: Amino Acid Sequence; Aspartic Acid; Carbodiimides; Catalysis; Circular Dichroism; Conserved Sequence; Glucosyltransferases; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Plant Proteins; Sequence Homology, Amino Acid; Starch Synthase; Substrate Specificity; Zea mays | 2000 |
The effect of intravenous insulin on accumulation of excitotoxic and other amino acids in the ischemic rat cerebral cortex.
Topics: Animals; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Energy Metabolism; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glycogen; Hypoglycemia; Hypoglycemic Agents; Injections, Intravenous; Insulin; Ischemic Attack, Transient; Lactic Acid; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Taurine | 2000 |
Adenosine A2A receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells.
Topics: Adenosine; Analysis of Variance; Animals; Aspartic Acid; Bicuculline; Cells, Cultured; Chick Embryo; Chromatography, High Pressure Liquid; Excitatory Amino Acids; Extracellular Space; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycolysis; Humans; Ischemia; Organophosphorus Compounds; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Retina; Triazines; Triazoles; Xanthines | 2000 |
The RGD sequence in the cytomegalovirus DNA polymerase accessory protein can mediate cell adhesion.
Topics: Amino Acid Sequence; Animals; Arginine; Aspartic Acid; Bacteriophage T7; Cell Adhesion; Culture Media; Cytomegalovirus; DNA-Binding Proteins; DNA-Directed DNA Polymerase; Glutamic Acid; Glycine; Humans; Mice; Molecular Sequence Data; Muromegalovirus; Oligopeptides; Vaccinia virus; Viral Nonstructural Proteins; Viral Proteins | 2000 |
3-Nitropropionic acid neurotoxicity in organotypic striatal and corticostriatal slice cultures is dependent on glucose and glutamate.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Glucose; Glutamate Decarboxylase; Glutamic Acid; Huntington Disease; In Vitro Techniques; Mitochondria; Nitro Compounds; Propionates; Rats; Succinate Dehydrogenase; Tetrodotoxin | 2000 |
Purification and characterization of cytosolic pyruvate kinase from Brassica napus (rapeseed) suspension cell cultures: implications for the integration of glycolysis with nitrogen assimilation.
Topics: Adenosine Diphosphate; Allosteric Regulation; Aspartic Acid; Brassica; Cells, Cultured; Chromatography, Affinity; Chromatography, Liquid; Cytosol; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glutamic Acid; Glycolysis; Hydrogen-Ion Concentration; Immunoblotting; Kinetics; Magnesium; Mitochondria; Models, Biological; Nitrogen; Plant Proteins; Potassium; Pyruvate Kinase; Temperature | 2000 |
Structures of chitobiase mutants complexed with the substrate Di-N-acetyl-d-glucosamine: the catalytic role of the conserved acidic pair, aspartate 539 and glutamate 540.
Topics: Acetylglucosamine; Acetylglucosaminidase; Amino Acid Substitution; Aspartic Acid; Binding Sites; Catalysis; Conserved Sequence; Crystallization; Crystallography, X-Ray; Glutamic Acid; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Protein Binding; Protein Conformation; Serratia marcescens; Structure-Activity Relationship; Thermodynamics | 2000 |
Identification of peptides in aggregates formed during hydrolysis of beta-lactoglobulin B with a Glu and Asp specific microbial protease.
Topics: Amino Acid Sequence; Aspartic Acid; Bacillus; Endopeptidases; Glutamic Acid; Hydrolysis; Lactoglobulins; Molecular Sequence Data; Peptide Fragments; Protein Folding; Protein Structure, Secondary; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity | 2000 |
Effect of hypertrophic cardiomyopathy mutations in human cardiac muscle alpha -tropomyosin (Asp175Asn and Glu180Gly) on the regulatory properties of human cardiac troponin determined by in vitro motility assay.
Topics: Animals; Asparagine; Aspartic Acid; Calcium; Cardiomegaly; Cardiomyopathies; Cell Movement; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; Heart; Humans; Microscopy, Fluorescence; Muscle Fibers, Fast-Twitch; Muscle, Skeletal; Mutagenesis; Myocardium; Rabbits; Recombinant Proteins; Tropomyosin; Troponin | 2000 |
Impaired secretion of rat mannose-binding protein resulting from mutations in the collagen-like domain.
Topics: Amino Acid Substitution; Animals; Arginine; Aspartic Acid; Carrier Proteins; CHO Cells; Collagen; Collectins; Complement Fixation Tests; Cricetinae; Cysteine; Endoplasmic Reticulum; Glutamic Acid; Glycine; Humans; Lectins; Lysine; Mannans; Mutagenesis, Site-Directed; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proteins; Rats; Time Factors; Transfection | 2000 |
Glutamine metabolism in endothelial cells: ornithine synthesis from glutamine via pyrroline-5-carboxylate synthase.
Topics: Alanine; Ammonia; Animals; Antimetabolites, Antineoplastic; Aorta; Asparagine; Aspartic Acid; Azaserine; Carbon Dioxide; Cattle; Cells, Cultured; Diazooxonorleucine; Endothelium, Vascular; Enzymes; Glutamic Acid; Glutamine; Humans; Microcirculation; Ornithine; Ornithine-Oxo-Acid Transaminase; Umbilical Veins; Venules | 2000 |
Inversion of stereospecificity of vanillyl-alcohol oxidase.
Topics: Alcohol Oxidoreductases; Amino Acid Substitution; Aspartic Acid; Binding Sites; Catalysis; Crystallography, X-Ray; Glutamic Acid; Hydrogen-Ion Concentration; Hydroxylation; Kinetics; Models, Molecular; Mutation; Penicillium; Phenols; Phenylethyl Alcohol; Protein Conformation; Protein Engineering; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity; Water | 2000 |
A structure-function study of a proton transport pathway in the gamma-class carbonic anhydrase from Methanosarcina thermophila.
Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Biological Transport; Carbonic Anhydrases; Cysteine; Deuterium; Escherichia coli; Genetic Variation; Glutamic Acid; Glutamine; Histidine; Hydrogen-Ion Concentration; Kinetics; Lysine; Methanosarcina; Mutagenesis, Site-Directed; Protons; Serine; Solvents; Structure-Activity Relationship; Threonine; Tryptophan | 2000 |
Characterization of the metal binding environment of catalytic site 1 of chloroplast F1-ATPase from Chlamydomonas.
Topics: Adenosine Diphosphate; Animals; Aspartic Acid; Binding Sites; Catalysis; Chlamydomonas reinhardtii; Chloroplasts; Electron Spin Resonance Spectroscopy; Glutamic Acid; Mutagenesis, Site-Directed; Protein Conformation; Proton-Translocating ATPases; Spin Labels; Vanadates | 2000 |
The effect of topical insulin on the release of excitotoxic and other amino acids from the rat cerebral cortex during streptozotocin-induced hyperglycemic ischemia.
Topics: Administration, Topical; Animals; Aspartic Acid; Blood Glucose; Brain Ischemia; Cerebral Cortex; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acids; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Hyperglycemia; Insulin; Lactic Acid; Male; Rats; Rats, Sprague-Dawley; Reperfusion; Taurine | 2000 |
Glutamate and aspartate immunoreactivity in dorsal root ganglion cells supplying visceral and somatic targets and evidence for peripheral axonal transport.
Topics: Animals; Aspartic Acid; Axonal Transport; Calcitonin Gene-Related Peptide; Ganglia, Spinal; Glutamic Acid; Male; Muscle, Skeletal; Neurons, Afferent; Peripheral Nerves; Rats; Rats, Wistar; Skin; Substance P; Viscera | 2000 |
No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke.
Topics: Adolescent; Aspartic Acid; Brain Ischemia; Child; Child, Preschool; Genetic Linkage; Glutamic Acid; Humans; Infant; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Stroke | 2000 |
Lactate prevents the alterations in tissue amino acids, decline in ATP, and cell damage due to aglycemia in retina.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Aspartic Acid; Chickens; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; In Vitro Techniques; L-Lactate Dehydrogenase; Lactates; Retina; Serine | 2000 |
Stimulation of synaptosomal D-[(3)H]aspartate transport by substance P in rat brain.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Brain; Dose-Response Relationship, Drug; Glutamic Acid; Rats; Rats, Wistar; Substance P; Synaptosomes; Tritium | 2000 |
Rapid glutamatergic alterations in the neural retina induced by retinal detachment.
Topics: Ambystoma; Animals; Aspartic Acid; Fluorescent Antibody Technique, Indirect; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Image Processing, Computer-Assisted; Immunoenzyme Techniques; Neurotransmitter Agents; Rabbits; Retina; Retinal Detachment | 2000 |
De novo sequencing of proteolytic peptides by a combination of C-terminal derivatization and nano-electrospray/collision-induced dissociation mass spectrometry.
Topics: Aldehyde Dehydrogenase; Amino Acid Sequence; Animals; Aspartic Acid; Cricetinae; Electrochemistry; Endopeptidases; Glutamic Acid; Hydrolysis; Liver; Mass Spectrometry; Mesocricetus; Molecular Sequence Data; Peptide Fragments; Peptides | 2000 |
Metabolic pathways for cytotoxic end product formation from glutamate- and aspartate-containing peptides by Porphyromonas gingivalis.
Topics: Acetic Acid; Acyl Coenzyme A; Adenosine Triphosphate; Amino Acids; Ammonia; Aspartic Acid; Butyrates; Culture Media; Cytotoxins; Dipeptides; Enzymes; Glutamic Acid; NADP; Oxidation-Reduction; Paraquat; Peptides; Porphyromonas gingivalis; Propionates | 2000 |
Striatal A2A adenosine receptor antagonism differentially modifies striatal glutamate outflow in vivo in young and aged rats.
Topics: Adenosine; Age Factors; Aging; Animals; Aspartic Acid; Glutamic Acid; Male; Neostriatum; Neurons; Neuroprotective Agents; Potassium; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Time Factors; Triazoles | 2000 |
Human, bovine, and rabbit retinal glutamate-induced [3H]D-aspartate release: role in excitotoxicity.
Topics: Adult; Aged; Animals; Aspartic Acid; Cattle; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Middle Aged; Rabbits; Receptors, Metabotropic Glutamate; Retina; Tritium | 2000 |
Two clusters of acidic amino acids near the NH2 terminus of complement component C4 alpha'-chain are important for C2 binding.
Topics: Amino Acid Sequence; Amino Acids; Animals; Antibodies, Blocking; Asparagine; Aspartic Acid; Binding Sites, Antibody; Complement C2; Complement C4; COS Cells; Glutamic Acid; Glutamine; Humans; Molecular Mimicry; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Protein Binding | 2000 |
In vitro selection of fluoroquinolone-resistant Neisseria gonorrhoeae harboring alterations in DNA gyrase and topoisomerase IV.
Topics: Anti-Infective Agents; Aspartic Acid; Ciprofloxacin; DNA Gyrase; DNA Topoisomerase IV; DNA Topoisomerases, Type II; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Genes, Bacterial; Glutamic Acid; Humans; Microbial Sensitivity Tests; Mutation; Neisseria gonorrhoeae; Norfloxacin; Ofloxacin; Selection, Genetic; Serine | 2000 |
Cytochrome c peroxidase-cytochrome c complex: locating the second binding domain on cytochrome c peroxidase with site-directed mutagenesis.
Topics: Animals; Aspartic Acid; Binding Sites; Calorimetry; Cytochrome c Group; Cytochrome-c Peroxidase; Cytochromes c; Glutamic Acid; Horses; Kinetics; Lysine; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Zinc | 2000 |
Relocation of internal bound water in bacteriorhodopsin during the photoreaction of M at low temperatures: an FTIR study.
Topics: Aspartic Acid; Bacteriorhodopsins; Cell Polarity; Glutamic Acid; Halobacterium; Mutation; Proton Pumps; Retinaldehyde; Schiff Bases; Spectroscopy, Fourier Transform Infrared; Threonine; Valine; Water | 2000 |
[Physiopathological and chemopathological mechanisms of central motor disorders in amyotrophic lateral sclerosis].
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Brain; Electromyography; Female; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Motor Neurons | 2000 |
Neurochemical changes after morphine, dizocilpine or riluzole in the ventral posterolateral thalamic nuclei of rats with hyperalgesia.
Topics: Analysis of Variance; Animals; Arginine; Aspartic Acid; Carrageenan; Citrulline; Dialysis Solutions; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamic Acid; Hindlimb; Hyperalgesia; Male; Microdialysis; Morphine; Neuroprotective Agents; Rats; Rats, Wistar; Riluzole; Thalamic Nuclei | 2000 |
The effects of J modulation on spin-echo acquisition and calculation of spin-spin relaxation time (T2) from the J-suppressed data set.
Topics: Algorithms; Aspartic Acid; Glutamic Acid; Magnetic Resonance Spectroscopy; Protons | 2000 |
beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Astrocytes; Basal Nucleus of Meynert; Calcium; Calcium Radioisotopes; Cells, Cultured; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate; Taurine | 2000 |
Environmental modulation of the response to amphetamine: dissociation between changes in behavior and changes in dopamine and glutamate overflow in the rat striatal complex.
Topics: Amphetamine; Animals; Apomorphine; Aspartic Acid; Behavior, Animal; Central Nervous System Stimulants; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Environment; Glutamic Acid; Male; Microdialysis; Neostriatum; Oxidopamine; Rats; Rats, Sprague-Dawley; Sympathectomy, Chemical; Sympatholytics | 2000 |
Glutamate-mediated neuroprotection against N-methyl-D-aspartate toxicity: a role for metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cell Death; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Neuroprotective Agents; Oligodeoxyribonucleotides, Antisense; Organ Culture Techniques; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Tetrodotoxin | 2000 |
Single-shot, three-dimensional "non-echo" localization method for in vivo NMR spectroscopy.
Topics: Acetates; Animals; Aspartic Acid; Brain Chemistry; Calibration; Carbon Isotopes; Evaluation Studies as Topic; Formates; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Glycogen; Inositol; Lipids; Magnetic Resonance Spectroscopy; Male; Muscle, Skeletal; Ostreidae; Phantoms, Imaging; Protons; Radio Waves; Rats; Sensitivity and Specificity | 2000 |
FT-IR spectroscopic characterization of NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli: oxidation of FeS cluster N2 is coupled with the protonation of an aspartate or glutamate side chain.
Topics: Alkanesulfonic Acids; Aspartic Acid; Buffers; Electrochemistry; Electron Transport Complex I; Escherichia coli; Glutamic Acid; Iron-Sulfur Proteins; Models, Chemical; Morpholines; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Peptide Fragments; Proton Pumps; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared | 2000 |
In vivo measurements of glutamine + glutamate (Glx) and N-acetyl aspartate (NAA) levels in human partial epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Brain; Case-Control Studies; Creatine; Diagnosis, Differential; Epilepsies, Partial; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neocortex; Temporal Lobe | 2000 |
Quantitative assessment of localization and colocalization of glutamate, aspartate, glycine, and GABA immunoreactivity in the chick retina.
Topics: Animals; Antibodies; Aspartic Acid; Chickens; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Immunohistochemistry; Neurotransmitter Agents; Photoreceptor Cells, Vertebrate; Retinal Ganglion Cells; Visual Pathways | 2000 |
Influence of different anaesthetics on extracellular aminoacids in rat brain.
Topics: Amino Acids; Anesthetics; Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Ischemia; Extracellular Space; Glutamic Acid; Glycine; Male; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Neurotransmitter Agents; Rats; Rats, Wistar | 2000 |
Mutagenesis and kinetic studies of a plant cysteine proteinase with an unusual arrangement of acidic amino acids in and around the active site.
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Cloning, Molecular; Cysteine Endopeptidases; DNA, Complementary; Escherichia coli; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Magnoliopsida; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Plant Proteins; Protein Precursors; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship | 2000 |
Müller cell protection of rat retinal ganglion cells from glutamate and nitric oxide neurotoxicity.
Topics: Animals; Aspartic Acid; Biomarkers; Cell Survival; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Glutamic Acid; Neuroglia; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Rats; Rats, Long-Evans; Retinal Ganglion Cells | 2000 |
Contribution of salt bridges near the surface of a protein to the conformational stability.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Calorimetry, Differential Scanning; Crystallization; Crystallography, X-Ray; Glutamic Acid; Glutamine; Hot Temperature; Humans; Hydrogen-Ion Concentration; Muramidase; Mutagenesis, Site-Directed; Potassium Chloride; Protein Conformation; Protein Denaturation; Salts; Surface Properties | 2000 |
Reducing postischemic reperfusion damage in neonates using a terminal warm substrate-enriched blood cardioplegic reperfusate.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Aspartic Acid; Blood; Cardioplegic Solutions; Glutamic Acid; Heart; Hemodynamics; Myocardial Reperfusion Injury; Myocardium; Oxygen Consumption; Swine; Temperature | 2000 |
Effect of chronic hyperprolactinemia on daily changes of glutamate and aspartate concentrations in the median eminence and different hypothalamic areas of male rats.
Topics: Animals; Aspartic Acid; Chronic Disease; Circadian Rhythm; Glutamic Acid; Glutamine; Hyperprolactinemia; Hypothalamus; Male; Median Eminence; Rats; Rats, Wistar; Tissue Distribution | 2000 |
Energetic consequences of accommodating a bulkier ligand at the active site of medium chain acyl-CoA dehydrogenase by creating a complementary enzyme site cavity.
Topics: Acyl Coenzyme A; Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Amino Acid Substitution; Animals; Aspartic Acid; Binding Sites; Catalysis; Glutamic Acid; Humans; Kidney; Kinetics; Ligands; Liver; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Spectrophotometry; Swine; Temperature; Thermodynamics; Titrimetry | 2000 |
Swarming of Pseudomonas aeruginosa is dependent on cell-to-cell signaling and requires flagella and pili.
Topics: Aspartic Acid; Bacterial Proteins; Culture Media; Decanoates; Disaccharides; DNA-Binding Proteins; Fimbriae Proteins; Fimbriae, Bacterial; Flagella; Flagellin; Glutamic Acid; Histidine; Microscopy, Electron; Movement; Mutation; Nitrogen; Proline; Pseudomonas aeruginosa; Rhamnose; Signal Transduction; Surface-Active Agents; Trans-Activators; Transcription Factors | 2000 |
Anxiety in healthy humans is associated with orbital frontal chemistry.
Topics: Adult; Analysis of Variance; Anxiety; Aspartic Acid; Choline; Creatinine; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurotransmitter Agents; Psychological Tests | 2000 |
Effects of alpha-dendrotoxin and dendrotoxin K on extracellular excitatory amino acids and on electroencephalograph spectral power in the hippocampus of anaesthetised rats.
Topics: Anesthesia; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Elapid Venoms; Electroencephalography; Excitatory Amino Acids; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Microinjections; Peptides; Potassium Channels; Rats; Rats, Wistar | 2000 |
Imipramine and phenelzine decrease glutamate overflow in the prefrontal cortex--a possible mechanism of neuroprotection in major depression?
Topics: Animals; Antidepressive Agents, Tricyclic; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Depressive Disorder; Glutamic Acid; Imipramine; Male; Neuroprotective Agents; Phenelzine; Prefrontal Cortex; Rats; Rats, Wistar | 2000 |
No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Child; Female; Gene Frequency; Genotype; Glutamic Acid; Humans; Japan; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide | 2000 |
The nicotinic modulation of [(3)H]D-aspartate outflow in primary cultures of rat neocortical neurons: effect of acute and long term nicotine treatment.
Topics: Acetylcholine; Animals; Aspartic Acid; Cells, Cultured; Electric Stimulation; Glutamic Acid; Neocortex; Neurons; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Presynaptic | 2000 |
Putative role of presynaptic alpha7* nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area.
Topics: Animals; Aspartic Acid; Extracellular Space; Glutamic Acid; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Tegmentum Mesencephali | 2000 |
Glutamate, GABA and precursor amino acids in adult mouse neocortex: cellular diversity revealed by quantitative immunocytochemistry.
Topics: Amino Acids; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Immunohistochemistry; Mice; Mice, Inbred C57BL; Neocortex; Neurons | 2000 |
Reduced operant ethanol self-administration and in vivo mesolimbic dopamine responses to ethanol in PKCepsilon-deficient mice.
Topics: Animals; Aspartic Acid; Brain; Conditioning, Operant; Crosses, Genetic; Dopamine; Ethanol; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Heterozygote; Isoenzymes; Limbic System; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Microdialysis; Motor Activity; Norepinephrine; Protein Kinase C; Protein Kinase C-epsilon; Self Administration; Serotonin; Taurine | 2000 |
Extracellular concentrations of taurine, glutamate, and aspartate in the cerebral cortex of rats at the asymptomatic stage of thioacetamide-induced hepatic failure: modulation by ketamine anesthesia.
Topics: Anesthetics, Dissociative; Animals; Aspartic Acid; Body Water; Cerebral Cortex; Extracellular Space; Glutamic Acid; Ketamine; Liver Failure; Male; Microdialysis; Rats; Rats, Wistar; Taurine; Thioacetamide | 2000 |
Effect of site-directed mutagenesis of the conserved aspartate and glutamate on E. coli undecaprenyl pyrophosphate synthase catalysis.
Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Aspartic Acid; Binding Sites; Catalysis; Conserved Sequence; Escherichia coli; Glutamic Acid; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; Substrate Specificity | 2000 |
Amino acid concentrations in rat cochlear nucleus and superior olive.
Topics: Amino Acids; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Cochlear Nucleus; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Olivary Nucleus; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2000 |
Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; CHO Cells; COS Cells; Cricetinae; Glutamic Acid; Humans; Kinetics; Models, Molecular; Molecular Structure; Patch-Clamp Techniques; Rats; Receptors, Glutamate; Stereoisomerism; Structure-Activity Relationship; Transfection | 2000 |
Heat-stress-induced hyperthermia alters CSF osmolality and composition in conscious rabbits.
Topics: Amino Acids; Animals; Aspartic Acid; Body Temperature; Body Temperature Regulation; gamma-Aminobutyric Acid; Glutamic Acid; Heat Stress Disorders; Hyperthermia, Induced; Male; Osmolar Concentration; Rabbits; Skin Temperature; Taurine; Time Factors | 2000 |
Noise-induced aspartate and glutamate efflux in the guinea pig cochlea and hearing loss.
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Cochlea; Evoked Potentials, Auditory, Brain Stem; Glutamic Acid; Guinea Pigs; Hearing Loss, Noise-Induced; Noise | 2000 |
Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats.
Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Excitatory Amino Acids; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Hypothermia, Induced; Nerve Degeneration; Neural Inhibition; Neurons; Rats; Rats, Inbred SHR; Taurine | 2000 |
Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.
Topics: Aspartic Acid; Binding Sites; Calorimetry, Differential Scanning; Cations, Monovalent; Cesium; Clostridium; Crystallography, X-Ray; Enzyme Stability; Formate-Tetrahydrofolate Ligase; Glutamic Acid; Glutamine; Mutagenesis, Site-Directed; Potassium; Protein Denaturation; Quaternary Ammonium Compounds; Thermodynamics | 2000 |
pH stability of HLA-DR4 complexes with antigenic peptides.
Topics: Adipokines; Amino Acid Sequence; Animals; Aspartic Acid; Autoantigens; Cadherins; Cartilage; Chitinase-3-Like Protein 1; Desmoglein 3; Glutamic Acid; Glycoproteins; HLA-DR4 Antigen; Humans; Hydrogen-Ion Concentration; Kinetics; Lectins; Mice; Models, Biological; Models, Chemical; Molecular Sequence Data; Pemphigus; Peptides; Protons; Recombinant Proteins; Solubility | 2000 |
3-Hydroxy-3-methylglutaryl-CoA synthase: participation of invariant acidic residues in formation of the acetyl-S-enzyme reaction intermediate.
Topics: Acetyl Coenzyme A; Acetylation; Alanine; Amino Acid Substitution; Amino Acids; Animals; Aspartic Acid; Catalysis; Enzyme Inhibitors; Ethyldimethylaminopropyl Carbodiimide; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Synthase; Mutagenesis, Site-Directed; Oxygen Isotopes; Recombinant Proteins; Solvents; Water | 2000 |
Neurochemical monitoring in the management of severe head-injured patients with hypothermia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Body Temperature; Brain; Craniocerebral Trauma; Female; Glutamic Acid; Humans; Hypothermia, Induced; Intracranial Pressure; Male; Microdialysis; Middle Aged; Nitric Oxide | 2000 |
Characterization of electrically evoked [3H]-D-aspartate release from hippocampal slices.
Topics: Animals; Aspartic Acid; Calcium; Cysteine; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Magnesium; Neurotransmitter Agents; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Stereoisomerism; Tritium | 2001 |
NMR spectroscopic study on the metabolic fate of [3-(13)C]alanine in astrocytes, neurons, and cocultures: implications for glia-neuron interactions in neurotransmitter metabolism.
Topics: Acetyl Coenzyme A; Alanine; Alanine Transaminase; Animals; Aspartic Acid; Astrocytes; Carbon Isotopes; Cell Communication; Cells, Cultured; Citric Acid Cycle; gamma-Aminobutyric Acid; Glutamate Dehydrogenase; Glutamic Acid; Glutamine; Lactic Acid; Magnetic Resonance Spectroscopy; Neurons; Neurotransmitter Agents; Protein Transport; Rats; Rats, Wistar | 2000 |
Purification and characterization of cytosolic pyruvate kinase from banana fruit.
Topics: Adenosine Diphosphate; Allosteric Regulation; Aspartic Acid; Cations; Coenzymes; Cytosol; Fruit; Glutamic Acid; Glyceric Acids; Hydrogen-Ion Concentration; Kinetics; Metals; Molecular Weight; Phosphoenolpyruvate; Phosphoenolpyruvate Carboxylase; Pyruvate Kinase; Thermodynamics; Zingiberales | 2000 |
Highly conserved glutamic acid in the extracellular IV-V loop in rhodopsins acts as the counterion in retinochrome, a member of the rhodopsin family.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Bacteriorhodopsins; Binding Sites; Cattle; Cell Line; Conserved Sequence; Extracellular Space; Glutamic Acid; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Retinal Pigments; Rhodopsin; Spectrophotometry | 2000 |
An examination of the role of asp-177 in the His-Asp catalytic dyad of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase: X-ray structure and pH dependence of kinetic parameters of the D177N mutant enzyme.
Topics: Aspartic Acid; Catalytic Domain; Crystallography, X-Ray; Glucose-6-Phosphate; Glucosephosphate Dehydrogenase; Glutamic Acid; Histidine; Hydrogen-Ion Concentration; Kinetics; Leuconostoc; Models, Chemical; Models, Molecular; Movement; Mutagenesis, Site-Directed; Mutation | 2000 |
Abnormal brain chemistry in chronic back pain: an in vivo proton magnetic resonance spectroscopy study.
Topics: Adult; Anxiety; Aspartic Acid; Back Pain; Brain Chemistry; Choline; Chronic Disease; Creatine; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Thalamus | 2000 |
Localization of glutamatergic/aspartatergic neurons projecting to the hypothalamic paraventricular nucleus studied by retrograde transport of [3H]D-aspartate autoradiography.
Topics: Afferent Pathways; Amygdala; Animals; Anterior Hypothalamic Nucleus; Arcuate Nucleus of Hypothalamus; Aspartic Acid; Autoradiography; Glutamic Acid; Hypothalamic Area, Lateral; Male; Midline Thalamic Nuclei; Neurons; Paraventricular Hypothalamic Nucleus; Preoptic Area; Rats; Rats, Sprague-Dawley; Septal Nuclei; Stereoisomerism; Suprachiasmatic Nucleus; Tritium; Ventromedial Hypothalamic Nucleus | 2000 |
Short TE in vivo (1)H MR spectroscopic imaging at 1.5 T: acquisition and automated spectral analysis.
Topics: Algorithms; Aspartic Acid; Brain; Choline; Computer Simulation; Creatine; Glutamic Acid; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy | 2000 |
Increasing the thermal stability of euphauserase. A cold-active and multifunctional serine protease from Antarctic krill.
Topics: Animals; Antarctic Regions; Aspartic Acid; Autolysis; Crustacea; Enzyme Stability; Glutamic Acid; Lysine; Models, Molecular; Multienzyme Complexes; Phenylalanine; Point Mutation; Protein Conformation; Serine Endopeptidases; Temperature | 2001 |
Cooperative changes in GABA, glutamate and activity levels: the missing link in cortical plasticity.
Topics: Animals; Aspartic Acid; Cats; Electrophysiology; Evoked Potentials, Visual; Functional Laterality; gamma-Aminobutyric Acid; Glutamic Acid; Neuronal Plasticity; Neurons; Photic Stimulation; Retina; Time Factors; Visual Cortex | 2000 |
alpha(2)-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Brimonidine Tartrate; Chromatography, Liquid; Electroretinography; Extracellular Space; Glutamic Acid; Ischemia; Male; Mass Spectrometry; Quinoxalines; Rats; Rats, Inbred BN; Retina; Retinal Ganglion Cells; Retinal Vessels; Vitreous Body; Yohimbine | 2001 |
Carboxyl residues in the active site of human phenol sulfotransferase (SULT1A1).
Topics: Amino Acid Sequence; Arylsulfotransferase; Aspartic Acid; Binding Sites; Computer Simulation; Dose-Response Relationship, Drug; Enzyme Activation; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Isoxazoles; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoadenosine Phosphosulfate; Substrate Specificity | 2000 |
Mutational analysis of two putative catalytic motifs of the type IV restriction endonuclease Eco57I.
Topics: Amino Acid Motifs; Amino Acid Sequence; Aspartic Acid; Binding Sites; Catalysis; DNA; DNA Methylation; DNA Mutational Analysis; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutamic Acid; Magnesium; Manganese; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Site-Specific DNA-Methyltransferase (Adenine-Specific); Structure-Activity Relationship | 2001 |
Relationship between NO synthesis, arginine transport, and intracellular arginine levels in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Arginine; Aspartic Acid; Biological Transport; Cells, Cultured; Female; Glutamic Acid; Glutamine; Interleukin-1; Lysine; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Ornithine; Rats; Rats, Long-Evans | 2000 |
Altered striatal amino acid neurotransmitter release monitored using microdialysis in R6/1 Huntington transgenic mice.
Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; gamma-Aminobutyric Acid; Glutamic Acid; Huntington Disease; Mice; Mice, Transgenic; Microdialysis; N-Methylaspartate; Neurotransmitter Agents; Potassium Chloride | 2001 |
Quantitative analysis of immunogold labeling indicates low levels and non-vesicular localization of L-aspartate in rat primary afferent terminals.
Topics: Animals; Aspartic Acid; Calibration; Glutamic Acid; Immunohistochemistry; Male; Nerve Endings; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Vesicles; Tissue Distribution | 2001 |
Basal ganglia metabolite concentrations in idiopathic Parkinson's disease and multiple system atrophy measured by proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Basal Ganglia; Choline; Creatine; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple System Atrophy; Parkinson Disease; Pilot Projects; Reference Values | 2000 |
Strategies for studies of neurotoxic mechanisms involving deficient transport of L-glutamate: antisense knockout in rat brain in vivo and changes in the neurotransmitter metabolism following inhibition of glutamate transport in guinea pig brain slices.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Brain; Cerebral Cortex; Dicarboxylic Acids; Female; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Oligodeoxyribonucleotides, Antisense; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thionucleotides | 2000 |
Transient increase in the high affinity [3H]-L-glutamate uptake activity during in vitro development of hippocampal neurons in culture.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Carrier Proteins; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Dicarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hippocampus; Kainic Acid; Neuroglia; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Symporters; Time Factors; Tritium | 2001 |
Possible linkage between glutamate transporter and mitogen-activated protein kinase cascade in cultured rat cortical astrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Blotting, Western; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurotransmitter Uptake Inhibitors; Phosphorylation; Pyrrolidines; Rats; Rats, Wistar; Receptors, Glutamate; Signal Transduction | 2001 |
Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo.
Topics: Animals; Aspartic Acid; Benzopyrans; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Space; Glutamic Acid; Hippocampus; Infarction, Middle Cerebral Artery; Male; Microdialysis; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Synaptic Transmission; Thiazoles | 2001 |
Identification of residues in the carboxy-terminal domain of Clostridium perfringens alpha-toxin (phospholipase C) which are required for its biological activities.
Topics: Amino Acid Substitution; Aspartic Acid; Bacterial Toxins; Calcium-Binding Proteins; Clostridium perfringens; DNA, Bacterial; Egg Yolk; Glutamic Acid; Glycine; Hemolysis; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Phospholipids; Phosphorylcholine; Protein Conformation; Serine; Substrate Specificity; Type C Phospholipases | 2000 |
Interactions between yeast iso-1-cytochrome c and its peroxidase.
Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Binding Sites; Calorimetry; Crystallography, X-Ray; Cytochrome c Group; Cytochrome-c Peroxidase; Cytochromes c; Glutamic Acid; Lysine; Macromolecular Substances; Mutagenesis, Site-Directed; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Solutions; Thermodynamics; Valine | 2001 |
Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site.
Topics: Alanine; Amidohydrolases; Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Binding Sites; Cations, Divalent; Conserved Sequence; Escherichia coli; Glutamic Acid; Gram-Negative Bacteria; Histidine; Molecular Sequence Data; Mutagenesis, Site-Directed; Zinc | 2001 |
Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse.
Topics: Adolescent; Age Factors; Aspartic Acid; Brain Injuries; Brain Ischemia; Case-Control Studies; Cerebral Ventricles; Child; Child Abuse; Child, Preschool; Disabled Persons; Excitatory Amino Acids; Glasgow Coma Scale; Glasgow Outcome Scale; Glutamic Acid; Glycine; Humans; Infant; Prognosis; Survival Analysis; Time Factors; Tomography, X-Ray Computed | 2001 |
Redistribution of neuroactive amino acids in hippocampus and striatum during hypoglycemia: a quantitative immunogold study.
Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Hypoglycemia; Immunohistochemistry; Insulin; Microscopy, Immunoelectron; Nerve Endings; Neurons; Neurotransmitter Agents; Rats; Rats, Wistar; Reference Values | 2001 |
[Evidence for glutamatergic neurotransmission in the geniculo-cortical pathway in the rat].
Topics: Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Female; Geniculate Bodies; Glutamic Acid; Iontophoresis; Kynurenic Acid; Male; Rats; Synaptic Transmission; Visual Cortex | 2000 |
Solution structure of DinI provides insight into its mode of RecA inactivation.
Topics: Aspartic Acid; Bacterial Proteins; DNA; DNA Repair; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Rec A Recombinases; Software | 2000 |
In vitro 1H and 31P NMR spectroscopic evidence of multiple aberrant biochemical pathways in murine trisomy 16 brain development.
Topics: Alanine; Animals; Aspartic Acid; Biomarkers; Brain Chemistry; Choline; Creatine; Disease Models, Animal; Down Syndrome; Female; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phosphorus Isotopes; Protons; Taurine; Threonine | 2000 |
Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138.
Topics: Alanine; Anti-HIV Agents; Aspartic Acid; Cell Line; Deoxyguanine Nucleotides; Dideoxynucleotides; DNA-Directed DNA Polymerase; Glutamic Acid; Glutamine; HIV Reverse Transcriptase; HIV-1; Humans; Lysine; Mutagenesis, Site-Directed; Nucleosides; Phenylalanine; Recombination, Genetic; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Spiro Compounds; Thymidine; Tyrosine; Uridine | 2001 |
Effect of acute alcohol on ischemia-induced glutamate release and brain damage.
Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Brain Ischemia; Ethanol; Frontal Lobe; Glutamic Acid; Kinetics; Male; Necrosis; Rats; Rats, Wistar; Rose Bengal | 2000 |
Extracellular amino acid levels measured with intracerebral microdialysis in the model of posttraumatic epilepsy induced by intracortical iron injection.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Cerebral Cortex; Craniocerebral Trauma; Electroencephalography; Epilepsy; Extracellular Space; Ferrous Compounds; Glutamic Acid; Injections; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Serine | 2001 |
Evidence for microvesicular storage and release of glycine in rodent pinealocytes.
Topics: Amino Acid Transport Systems; Animals; Aspartic Acid; Carrier Proteins; Cells, Cultured; gamma-Aminobutyric Acid; Gerbillinae; Glutamic Acid; Glycine; Immunohistochemistry; Microscopy, Electron; Pineal Gland; Potassium Chloride; Rats; Rats, Wistar; Secretory Vesicles; Vesicular Inhibitory Amino Acid Transport Proteins; Vesicular Transport Proteins | 2001 |
Aldehyde dehydrogenase. Maintaining critical active site geometry at motif 8 in the class 3 enzyme.
Topics: Aldehyde Dehydrogenase; Amino Acid Motifs; Animals; Aspartic Acid; Binding Sites; Catalysis; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutamic Acid; Humans; Hydrogen Bonding; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Phenylalanine; Rats | 2001 |
Critical role of glutamic acid 202 in the enzymatic activity of stromelysin-1 (MMP-3).
Topics: Alanine; Aspartic Acid; Binding Sites; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Escherichia coli; Fibrinolysin; Glutamic Acid; Humans; Hydrolysis; Kinetics; Lysine; Matrix Metalloproteinase 3; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Phenylmercuric Acetate; Plasminogen; Protein Binding; Protein Structure, Tertiary; Sequence Analysis, DNA; Time Factors; Urokinase-Type Plasminogen Activator; Zinc | 2001 |
Large inter-experiment variations in microdialysate aspartate and glutamate in rat striatum may reflect a circannual rhythm.
Topics: Animals; Aspartic Acid; Glutamic Acid; Male; Microdialysis; Neostriatum; Observer Variation; Rats; Rats, Sprague-Dawley; Seasons | 2001 |
Engineering conformational flexibility in the lactose permease of Escherichia coli: use of glycine-scanning mutagenesis to rescue mutant Glu325-->Asp.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Biological Transport, Active; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Glycine; Kinetics; Membrane Transport Proteins; Molecular Sequence Data; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Secondary; Symporters; Valine | 2001 |
Direct evidence for the protonation of aspartate-75, proposed to be at a quinol binding site, upon reduction of cytochrome bo3 from Escherichia coli.
Topics: Amides; Aspartic Acid; Binding Sites; Cytochrome b Group; Cytochromes; Electrochemistry; Electron Transport Complex IV; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Histidine; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxidoreductases; Protons; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Ubiquinone | 2001 |
A comparative assessment of the efficacy and side-effect liability of neuroprotective compounds in experimental stroke.
Topics: Animals; Aspartic Acid; Extracellular Space; Glutamic Acid; Hypoxia-Ischemia, Brain; Male; Mice; Mice, Inbred C57BL; Middle Cerebral Artery; Neuroprotective Agents; Postural Balance; Receptors, N-Methyl-D-Aspartate; Stroke | 2001 |
Characterization of transient focal ischemia-induced increases in extracellular glutamate and aspartate in spontaneously hypertensive rats.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Brain; Brain Ischemia; Extracellular Space; Glutamic Acid; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Rats; Rats, Inbred SHR; Reperfusion Injury; Tetrodotoxin; Time Factors | 2000 |
Occurrence of D-Amino Acids and a pyridoxal 5'-phosphate-dependent aspartate racemase in the acidothermophilic archaeon, Thermoplasma acidophilum.
Topics: Alanine; Amino Acid Isomerases; Amino Acids; Aspartic Acid; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethylmaleimide; Glutamic Acid; Leucine; Lysine; Phenylalanine; Pyridoxal Phosphate; Stereoisomerism; Thermoplasma | 2001 |
Prevalence and conditions of selection of E44D/A and V118I human immunodeficiency virus type 1 reverse transcriptase mutations in clinical practice.
Topics: Alanine; Amino Acid Substitution; Anti-HIV Agents; Aspartic Acid; Drug Resistance, Microbial; Gene Frequency; Glutamic Acid; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Isoleucine; Mutation; Valine | 2001 |
Structural and functional consequences of altering a peptide MHC anchor residue.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antigen Presentation; Aspartic Acid; Cells, Cultured; Crystallography, X-Ray; Glutamic Acid; Hemoglobins; Histocompatibility Antigens Class II; Kinetics; Ligands; Mice; Mice, Inbred CBA; Models, Molecular; Molecular Sequence Data; Peptides; Protein Conformation; Receptors, Antigen, T-Cell; Structure-Activity Relationship; T-Lymphocytes | 2001 |
Real-time, two-dimensional visualization of ischaemia-induced glutamate release from hippocampal slices.
Topics: Alanine; Aspartic Acid; Brain Ischemia; Calcium Signaling; Cell Line; Computer Systems; Dentate Gyrus; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Hot Temperature; Image Processing, Computer-Assisted; Microscopy, Fluorescence; Microscopy, Video; Potassium; Receptors, N-Methyl-D-Aspartate; Solutions; Taurine | 2001 |
Nicotinic receptors mediate the release of amino acid neurotransmitters in cultured cortical neurons.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hexamethonium; Membrane Potentials; Neurons; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Receptors, Nicotinic | 2001 |
Poly(amino acid) bioadhesives for tissue repair.
Topics: Adhesiveness; Amino Acids; Animals; Asparagine; Aspartic Acid; Biocompatible Materials; Cartilage; Cattle; Chondroitin Sulfates; Glass; Glutamic Acid; Hydrogen Bonding; Lysine; Materials Testing; Models, Chemical; Models, Molecular; Permeability; Tissue Adhesions; Tissue Adhesives; Wound Healing; Wounds and Injuries | 2000 |
Significance of glutamate and dopamine neurons in the ventral pallidum in the expression of behavioral sensitization to amphetamine.
Topics: Amphetamine; Animals; Aspartic Acid; Behavior, Animal; Central Nervous System Stimulants; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Globus Pallidus; Glutamic Acid; Male; Motor Activity; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2001 |
Effects of L-glutamate, D-aspartate, and monensin on glycolytic and oxidative glucose metabolism in mouse astrocyte cultures: further evidence that glutamate uptake is metabolically driven by oxidative metabolism.
Topics: Animals; Aspartic Acid; Astrocytes; Energy Metabolism; Enzyme Activation; Glucose; Glutamic Acid; Glycolysis; Mice; Monensin; Oxidation-Reduction; Sodium-Potassium-Exchanging ATPase | 2001 |
Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Benzofurans; Binding, Competitive; Cells, Cultured; Dicarboxylic Acids; Dose-Response Relationship, Drug; Ethers, Cyclic; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glutamic Acid; Intracellular Fluid; Kainic Acid; Mice; Neurotransmitter Uptake Inhibitors; Protein Isoforms; Pyrrolidines; Sodium; Stereoisomerism | 2001 |
Changes in striatal electroencephalography and neurochemistry induced by kainic acid seizures are modified by dopamine receptor antagonists.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Benzazepines; Corpus Striatum; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Electroencephalography; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Guinea Pigs; Homovanillic Acid; Kainic Acid; Neurochemistry; Receptors, Dopamine D1; Receptors, Dopamine D2; Seizures; Sulpiride | 2001 |
Zinc and copper bind to unique sites of histatin 5.
Topics: Aspartic Acid; Copper; Glutamic Acid; Histatins; Histidine; Humans; Ligands; Magnetic Resonance Spectroscopy; Protein Binding; Salivary Proteins and Peptides; Zinc | 2001 |
Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene.
Topics: Amino Acid Sequence; Arginine; Aspartic Acid; Breast Neoplasms; Female; Glutamic Acid; Glycine; Humans; Lung Neoplasms; Melanoma; Molecular Sequence Data; Neoplasms; Peptide Fragments; Phosphoprotein Phosphatases; Point Mutation; Protein Binding; Protein Phosphatase 2; Protein Structure, Secondary; Tryptophan | 2001 |
[Biochemical mechanisms of impaired neuroimmune interaction in multiple sclerosis].
Topics: Adult; Aspartic Acid; Biomarkers; Brain; Cell Death; Female; Glutamic Acid; Humans; Interferon-alpha; Interferon-gamma; Male; Multiple Sclerosis; Oligodendroglia; T-Lymphocytes, Regulatory; Time Factors; Tumor Necrosis Factor-alpha | 2000 |
Intrathecal magnesium sulfate attenuates algogenic behavior and spinal amino acids release after kainic acid receptor activation in rats.
Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; Calcium Channel Blockers; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Kainic Acid; Magnesium Sulfate; Male; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Taurine | 2001 |
Cadmium toxicity in synaptic neurotransmission in the brain.
Topics: Amygdala; Animals; Aspartic Acid; Cadmium Chloride; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Microdialysis; Rats; Rats, Wistar; Synapses; Synaptic Transmission | 2001 |
1-(13)C glucose magnetic resonance spectroscopy of pediatric and adult brain disorders.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Canavan Disease; Carbon Isotopes; Child; Child, Preschool; Female; Glucose; Glutamic Acid; Hepatic Encephalopathy; Humans; Infant, Newborn; Infant, Premature; Kinetics; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged | 2001 |
Differential lipid specificities of the repeated domains of annexin IV.
Topics: Alanine; Annexin A4; Aspartic Acid; Binding Sites; Calcium; Glutamic Acid; Liposomes; Membrane Lipids; Mutation; Phospholipids; Sodium Chloride | 2001 |
The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, and X-ray crystallography.
Topics: Alanine; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Crystallography, X-Ray; Enzyme Activation; Escherichia coli; Genetic Complementation Test; Glutamic Acid; Glutamine; Humans; Hydrogen-Ion Concentration; Hypoxanthine Phosphoribosyltransferase; Kinetics; Mutagenesis, Site-Directed; Plasmodium falciparum; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity | 2001 |
Mutagenesis of two acidic active site residues in human muscle creatine kinase: implications for the catalytic mechanism.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Catalysis; Creatine Kinase; Creatine Kinase, MM Form; Creatinine; Glutamic Acid; Humans; Isoenzymes; Kinetics; Molecular Sequence Data; Muscle, Skeletal; Mutagenesis, Site-Directed; Sequence Homology, Amino Acid | 2001 |
Characterization of the glutamatergic system for induction and maintenance of allodynia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; ATP-Binding Cassette Transporters; Capsaicin; Dinoprost; Dinoprostone; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Pain; Pain Measurement; Physical Stimulation; Posterior Horn Cells; Receptors, Glutamate; Synapses; Synaptic Transmission; Touch | 2001 |
Enzymatic coupling of specific peptides at nonspecific ligation sites: effect of Asp189Glu mutation in trypsin on substrate mimetic-mediated reactions.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Base Sequence; DNA Primers; Glutamic Acid; Hydrolysis; Molecular Mimicry; Peptides; Substrate Specificity; Trypsin | 2001 |
Pituitary hormone and insulin responses to infusion of amino acids and N-methyl-D,L-aspartate in horses.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Female; Glutamic Acid; Growth Hormone; Horses; Insulin; Lysine; Male; N-Methylaspartate; Pituitary Hormones; Prolactin; Radioimmunoassay; Thyrotropin | 2001 |
The solvent shells of cluster ions produced by direct electric field extraction from glycerol/water mixtures.
Topics: Algorithms; Amino Acids; Ascorbic Acid; Aspartic Acid; Aspirin; Glutamic Acid; Glycerol; Hydrocarbons, Halogenated; Ions; Membranes; Models, Theoretical; Molecular Structure; Niacin; Salicylic Acid; Spectrometry, Mass, Electrospray Ionization; Water | 2001 |
A family of yeast proteins mediating bidirectional vacuolar amino acid transport.
Topics: Amino Acid Sequence; Amino Acids; Aspartic Acid; Biological Transport; Carrier Proteins; Fluorescent Antibody Technique, Indirect; Fungal Proteins; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamic Acid; Intracellular Membranes; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Organic Anion Transporters; Phylogeny; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Tyrosine; Vacuoles | 2001 |
Analysis of extracellular gamma-aminobutyric acid, glutamate and aspartate in cat visual cortex by in vivo microdialysis and capillary electrophoresis-laser induced fluorescence detection.
Topics: Animals; Aspartic Acid; Cats; Electrophoresis, Capillary; Fluorescein-5-isothiocyanate; Fluorescent Dyes; gamma-Aminobutyric Acid; Glutamic Acid; Lasers; Microdialysis; Visual Cortex | 2001 |
Biochemical analysis of point mutations in the 5'-3' exonuclease of DNA polymerase I of Streptococcus pneumoniae. Functional and structural implications.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Catalysis; Catalytic Domain; Conserved Sequence; DNA; DNA Polymerase I; DNA, Single-Stranded; Dose-Response Relationship, Drug; Exodeoxyribonuclease V; Exodeoxyribonucleases; Glutamic Acid; Histidine; Kinetics; Ligands; Magnesium Chloride; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutation; Plasmids; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Streptococcus pneumoniae | 2001 |
A quantitative molecular model for modulation of mammalian translation by the eIF4E-binding protein 1.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid; Carrier Proteins; Cell Cycle Proteins; Chromatography, Affinity; Glutamic Acid; Mammals; Models, Molecular; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Recombinant Proteins; Surface Plasmon Resonance | 2001 |
Delta 3,5,delta 2,4-dienoyl-CoA isomerase is a multifunctional isomerase. A structural and mechanistic study.
Topics: Acyl Coenzyme A; Alanine; Amino Acid Sequence; Animals; Aspartic Acid; Carbon-Carbon Double Bond Isomerases; Catalysis; Circular Dichroism; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutamic Acid; Immunoblotting; Mitochondria; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Myocardium; Peroxisomes; Rats; Recombinant Proteins; Spectrophotometry; Stereoisomerism; Structure-Activity Relationship; Ultraviolet Rays | 2001 |
Solution structure, backbone dynamics, and stability of a double mutant single-chain monellin. structural origin of sweetness.
Topics: Arginine; Aspartic Acid; Chromatography, Gel; Chromatography, High Pressure Liquid; Circular Dichroism; Glutamic Acid; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Plant Proteins; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Spectrometry, Fluorescence; Sweetening Agents; Temperature | 2001 |
Dynamics of the proton transfer reaction on the cytoplasmic surface of bacteriorhodopsin.
Topics: Anions; Arylsulfonates; Aspartic Acid; Bacteriorhodopsins; Binding Sites; Buffers; Carboxylic Acids; Cytoplasm; Extracellular Space; Fluorescent Dyes; Glutamic Acid; Halobacterium salinarum; Kinetics; Lasers; Models, Molecular; Mutagenesis, Site-Directed; Peptide Fragments; Photolysis; Protons; Static Electricity; Surface Properties; Thermodynamics | 2001 |
Regulation of mitochondrial glutamine/glutamate metabolism by glutamate transport: studies with (15)N.
Topics: Ammonia; Animals; Aspartic Acid; Cell Line; Cytosol; Extracellular Space; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Intracellular Fluid; Kidney Tubules, Proximal; Kinetics; Mitochondria; Models, Chemical; Nitrogen Isotopes; Stereoisomerism | 2001 |
Altered expression of glutamate transporters under hypoxic conditions in vitro.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Carrier Proteins; Cell Death; Cell Hypoxia; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Gene Expression Regulation; Glioma; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hypothalamic Neoplasms; Indoles; Maleimides; Mice; Mitochondria; Nerve Tissue Proteins; Neuroglia; Neurons; Protein Kinase C; Rats; Receptors, Neurotransmitter; Recombinant Fusion Proteins; RNA, Messenger; Symporters; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 2001 |
Spatial heterogeneity of energy turnover in the heart.
Topics: Alanine; Animals; Aspartic Acid; Carbon Isotopes; Citric Acid; Citric Acid Cycle; Coronary Circulation; Dogs; Energy Metabolism; Glutamic Acid; Ketoglutaric Acids; Lactic Acid; Magnetic Resonance Spectroscopy; Malates; Models, Biological; Myocardium; Oxaloacetic Acid; Oxygen Consumption; Pyruvic Acid | 2001 |
In vivo 1H magnetic resonance spectroscopic measurement of brain glycine levels in nonketotic hyperglycinemia.
Topics: Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Chromosome Aberrations; Chromosome Disorders; Creatine; Follow-Up Studies; Genes, Recessive; Glutamic Acid; Glutamine; Glycine; Humans; Hyperglycinemia, Nonketotic; Infant; Infant, Newborn; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male | 2001 |
A study into the role of L-aspartic acid on the metabolism of L-malic acid and D-glucose by Oenococcus oeni.
Topics: Aspartic Acid; Culture Media; Fermentation; Glucose; Glutamic Acid; Gram-Positive Cocci; Leuconostoc; Malates | 2001 |
Relationship between the G894T polymorphism (Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis.
Topics: Aged; Amino Acid Substitution; Arteriosclerosis; Aspartic Acid; Endothelium, Vascular; Female; Genotype; Glutamic Acid; Humans; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Risk Factors; Saphenous Vein; Vasomotor System | 2001 |
Site-directed mutagenesis of human membrane-associated ganglioside sialidase: identification of amino-acid residues contributing to substrate specificity.
Topics: Amino Acid Sequence; Amino Acids; Animals; Arginine; Aspartic Acid; Binding Sites; Blotting, Western; Cell Membrane; COS Cells; Gangliosides; Glutamic Acid; Glutamine; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neuraminidase; Rats; Salmonella typhimurium; Sequence Homology, Amino Acid; Substrate Specificity; Temperature; Transfection | 2001 |
Carboxyl group of residue Asp647 as possible proton donor in catalytic reaction of alpha-glucosidase from Schizosaccharomyces pombe.
Topics: alpha-Glucosidases; Amino Acid Sequence; Aspartic Acid; Base Sequence; Catalysis; Circular Dichroism; Cloning, Molecular; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Gene Library; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Open Reading Frames; Plasmids; Protons; Recombinant Proteins; RNA, Messenger; Schizosaccharomyces; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Temperature; Time Factors | 2001 |
Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Carrier Proteins; Cell Line; Cerebellum; Cerebral Cortex; Dogs; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Excitatory Amino Acid Transporter 4; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hippocampus; Kidney; Kinetics; Neurotransmitter Uptake Inhibitors; Oocytes; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Neurotransmitter; Recombinant Fusion Proteins; Symporters; Synaptosomes; Xenopus laevis | 2001 |
ATP stimulates calcium-dependent glutamate release from cultured astrocytes.
Topics: 4-Chloromercuribenzenesulfonate; Adenosine Triphosphate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Caffeine; Calcium Signaling; Calcium-Transporting ATPases; Cells, Cultured; Cerebral Cortex; Chelating Agents; Chloride Channels; Chromatography, High Pressure Liquid; Egtazic Acid; Enzyme Inhibitors; Estrenes; Furosemide; Glutamic Acid; Ion Transport; Nitrobenzoates; Phosphatidylinositol Diacylglycerol-Lyase; Pyrrolidinones; Rats; Ryanodine; Sodium; Thapsigargin; Type C Phospholipases | 2001 |
The Glu298Asp polymorphism in the NOS3 gene is not associated with sporadic Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Glutamic Acid; Humans; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Genetic | 2001 |
Mechanism of action of Escherichia coli ribonuclease III. Stringent chemical requirement for the glutamic acid 117 side chain and Mn2+ rescue of the Glu117Asp mutant.
Topics: Aspartic Acid; Base Sequence; Binding Sites; Catalysis; Catalytic Domain; Cations, Divalent; Endoribonucleases; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Hydrolysis; Magnesium; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; Organophosphates; Protein Structure, Tertiary; Ribonuclease III; RNA Processing, Post-Transcriptional; Substrate Specificity | 2001 |
Vaginocervical stimulation-induced release of classical neurotransmitters and nitric oxide in the nucleus of the solitary tract varies as a function of the oestrus cycle.
Topics: Animals; Arginine; Aspartic Acid; Cervix Uteri; Denervation; Estrus; Female; gamma-Aminobutyric Acid; Genitalia, Female; Glutamic Acid; Hypogastric Plexus; Microdialysis; Neurons; Neurotransmitter Agents; Nitric Oxide; Norepinephrine; Physical Stimulation; Rats; Rats, Wistar; Solitary Nucleus; Vagina; Vagus Nerve; Visceral Afferents | 2001 |
Structures of the acyl-enzyme complexes of the Staphylococcus aureus beta-lactamase mutant Glu166Asp:Asn170Gln with benzylpenicillin and cephaloridine.
Topics: Acylation; Amino Acid Substitution; Asparagine; Aspartic Acid; beta-Lactamases; Binding Sites; Catalysis; Cephaloridine; Crystallization; Crystallography, X-Ray; Escherichia coli; Glutamic Acid; Glutamine; Hydrolysis; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; Penicillin G; Staphylococcus aureus; Substrate Specificity | 2001 |
The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition.
Topics: Aminobutyrates; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Computer Simulation; Crystallography, X-Ray; Electrons; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamic Acid; Models, Molecular; Salmonella typhimurium; Spectroscopy, Fourier Transform Infrared; Static Electricity; Substrate Specificity; Thallium; Tyrosine | 2001 |
Mitochondrial phosphate transport protein. Reversions of inhibitory conservative mutations identify four helices and a nonhelix protein segment with transmembrane interactions and Asp39, Glu137, and Ser158 as nonessential for transport.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Biological Transport, Active; Carrier Proteins; Catalysis; Conserved Sequence; Genetic Vectors; Glutamic Acid; Liposomes; Membrane Proteins; Mitochondria; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Phosphate-Binding Proteins; Phosphates; Plasmids; Protein Conformation; Protein Structure, Secondary; Saccharomyces cerevisiae; Serine; Solubility; Transformation, Genetic | 2001 |
Characterization of the Glu and Asp residues in the active site of human beta-hexosaminidase B.
Topics: Acetylglucosaminidase; Amino Acid Substitution; Animals; Aspartic Acid; beta-N-Acetylhexosaminidases; Binding Sites; Catalysis; CHO Cells; Cricetinae; Glutamic Acid; Hexosaminidase B; Humans; Isoenzymes; Kinetics; Membrane Proteins; Mutagenesis, Site-Directed; Protein Conformation; Reproducibility of Results; Sequence Alignment; Sequence Homology, Amino Acid; Tetraspanins; Transfection | 2001 |
The role of Glu39 in MnII binding and oxidation by manganese peroxidase from Phanerochaete chrysoporium.
Topics: Amino Acid Substitution; Aspartic Acid; Binding Sites; Computer Simulation; Glutamic Acid; Kinetics; Manganese; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Peroxidases; Phanerochaete; Recombinant Proteins; Sequence Analysis, DNA; Spectrophotometry, Ultraviolet | 2001 |
Acidic hydrolysis as a mechanism for the cleavage of the Glu(298)-->Asp variant of human endothelial nitric-oxide synthase.
Topics: Amino Acid Substitution; Aspartic Acid; Glutamic Acid; Humans; Hydrolysis; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Conformation; Structure-Activity Relationship | 2001 |
Vasorelaxation induced by L-glutamate in porcine coronary arteries.
Topics: Animals; Aspartic Acid; Coronary Vessels; Drug Interactions; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Histamine; N-Methylaspartate; Potassium; Swine; Vasodilation | 2001 |
Structural basis for the activity and substrate specificity of Erwinia chrysanthemi L-asparaginase.
Topics: Amino Acid Sequence; Asparaginase; Aspartic Acid; Binding Sites; Crystallization; Crystallography, X-Ray; Dickeya chrysanthemi; Glutamic Acid; Ligands; Macromolecular Substances; Molecular Sequence Data; Structure-Activity Relationship; Substrate Specificity; Succinic Acid | 2001 |
Crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase of riboflavin biosynthesis.
Topics: Aspartic Acid; Binding Sites; Catalysis; Crystallography, X-Ray; Cysteine; Dimerization; Escherichia coli; Glutamic Acid; Histidine; Intramolecular Transferases; Magnesium; Models, Chemical; Models, Molecular; Protein Structure, Secondary; Riboflavin; Riboflavin Synthase | 2001 |
Stabilization of apoflavodoxin by replacing hydrogen-bonded charged Asp or Glu residues by the neutral isosteric Asn or Gln.
Topics: Amino Acid Substitution; Anabaena; Apoproteins; Asparagine; Aspartic Acid; Bacterial Proteins; Base Sequence; Circular Dichroism; Cyanobacteria; Flavodoxin; Glutamic Acid; Glutamine; Hot Temperature; Hydrogen Bonding; Hydrogen-Ion Concentration; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Protein Denaturation; Urea | 2001 |
Latent specificity of molecular recognition in sodium channels engineered to discriminate between two "indistinguishable" mu-conotoxins.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Aspartic Acid; Conotoxins; Glutamic Acid; Glutamine; Lysine; Membrane Potentials; Molecular Sequence Data; Mollusk Venoms; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Protein Binding; Rats; Sodium Channel Blockers; Sodium Channels; Thermodynamics | 2001 |
The missense Glu298Asp variant of the endothelial nitric oxide synthase gene is strongly associated with placental abruption.
Topics: Abruptio Placentae; Adult; Aspartic Acid; DNA; Female; Gene Frequency; Genetic Testing; Genotype; Glutamic Acid; Humans; Mutation, Missense; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pregnancy | 2001 |
Biochemical characterization and identification of catalytic residues in alpha-glucuronidase from Bacillus stearothermophilus T-6.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Binding Sites; Calorimetry, Differential Scanning; Catalysis; Catalytic Domain; Chromatography, Gel; Cysteine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Geobacillus stearothermophilus; Glutamic Acid; Glycoside Hydrolases; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Sequence Analysis, Protein; Sequence Homology, Amino Acid; Temperature; Trioses | 2001 |
The effect of net charge on the solubility, activity, and stability of ribonuclease Sa.
Topics: Aspartic Acid; Circular Dichroism; Escherichia coli; Glutamic Acid; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Protein Denaturation; Ribonucleases; Solubility; Temperature; Thermodynamics | 2001 |
Electrically induced release of labelled taurine, alpha- and beta-alanine, glycine, glutamate and other amino acids from rat neocortical slices in vitro.
Topics: Alanine; Animals; Aspartic Acid; Carnosine; Electric Stimulation; Glutamic Acid; Glycine; Histidine; Neocortex; Neurons; Organ Culture Techniques; Rats; Serine; Taurine; Tritium | 1976 |
Active site residues of glutamate racemase.
Topics: Amino Acid Isomerases; Amino Acid Sequence; Asparagine; Aspartic Acid; Bacterial Proteins; Binding Sites; Deuterium; Glutamic Acid; Glutamine; Histidine; Isoenzymes; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; Sequence Alignment | 2001 |
Folate activation and catalysis in methylenetetrahydrofolate reductase from Escherichia coli: roles for aspartate 120 and glutamate 28.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Catalysis; Enzyme Activation; Escherichia coli; Folic Acid; Glutamic Acid; Glutamine; Kinetics; Methylenetetrahydrofolate Dehydrogenase (NAD+); Methylenetetrahydrofolate Reductase (NADPH2); Mutagenesis, Site-Directed; NAD; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Oxidoreductases; Oxidoreductases Acting on CH-NH Group Donors; Spectrophotometry; Vitamin K | 2001 |
Mutational analysis of catalytic sites of the cell wall lytic N-acetylmuramoyl-L-alanine amidases CwlC and CwlV.
Topics: Amino Acid Sequence; Amino Acids; Aspartic Acid; Bacillus; Bacillus subtilis; Bacterial Proteins; Calcium; Catalysis; Catalytic Domain; Cations; Cell Wall; Circular Dichroism; Cobalt; DNA Mutational Analysis; Electrophoresis, Polyacrylamide Gel; Gene Deletion; Glutamic Acid; Magnesium; Manganese; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Acetylmuramoyl-L-alanine Amidase; Peptidoglycan; Plasmids; Point Mutation; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Time Factors; Zinc | 2001 |
Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.
Topics: Adrenergic beta-Agonists; Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Aspartic Acid; Cell Line; Cell Membrane; Chlorocebus aethiops; Conserved Sequence; COS Cells; Cyclic AMP; Cytoplasm; Glutamic Acid; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Propanolamines; Protein Structure, Secondary; Receptors, Adrenergic, beta-2; Recombinant Proteins; Transfection | 2001 |
Response of metabolites with coupled spins to the STEAM sequence.
Topics: Aspartic Acid; Brain; Computer Simulation; Energy Metabolism; Glutamic Acid; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Parietal Lobe; Phantoms, Imaging | 2001 |
Activation of arrestin: requirement of phosphorylation as the negative charge on residues in synthetic peptides from the carboxyl-terminal region of rhodopsin.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Arrestin; Aspartic Acid; Cattle; Cyclic GMP; Cysteic Acid; Electrophoresis, Polyacrylamide Gel; Glutamic Acid; Peptide Fragments; Phosphorylation; Rhodopsin; Rod Cell Outer Segment; Sulfhydryl Compounds; Vision, Ocular | 2001 |
Identification of the proton pathway in bacterial reaction centers: cooperation between Asp-M17 and Asp-L210 facilitates proton transfer to the secondary quinone (QB).
Topics: Aspartic Acid; Benzoquinones; Electron Transport; Glutamic Acid; Glutamine; Kinetics; Mutagenesis, Site-Directed; Peptides; Photolysis; Photosynthetic Reaction Center Complex Proteins; Protons; Rhodobacter sphaeroides; Static Electricity | 2001 |
In vivo 1H MR spectra analysis by means of second derivative method.
Topics: Adult; Amino Acids; Aspartic Acid; Brain; Choline; Creatine; Deuterium Oxide; Energy Metabolism; Female; Glucose; Glutamic Acid; Humans; Hydrogen; Inositol; Likelihood Functions; Magnetic Resonance Spectroscopy; Male; Normal Distribution; Reference Values; Reproducibility of Results | 2001 |
Engineering a functional blue-wavelength-shifted rhodopsin mutant.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid; Cattle; COS Cells; Glutamic Acid; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Photochemistry; Retinaldehyde; Rhodopsin; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thermodynamics; Threonine; Transducin | 2001 |
A Na+-dependent electrogenic glutamate transporter current in voltage-clamped cells of corpora allata in the cricket Gryllus bimaculatus.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Corpora Allata; Electric Conductivity; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Gryllidae; Male; Patch-Clamp Techniques; Receptors, Glutamate; Sodium; Substrate Specificity | 2001 |
Catalytic acid-base groups in yeast pyruvate decarboxylase. 1. Site-directed mutagenesis and steady-state kinetic studies on the enzyme with the D28A, H114F, H115F, and E477Q substitutions.
Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Carbon Dioxide; Catalysis; Catalytic Domain; Cloning, Molecular; DNA, Recombinant; Enzyme Activation; Glutamic Acid; Glutamine; Histidine; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Phenylalanine; Pyruvate Decarboxylase; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity; Thiamine Pyrophosphate | 2001 |
Catalytic acid-base groups in yeast pyruvate decarboxylase. 2. Insights into the specific roles of D28 and E477 from the rates and stereospecificity of formation of carboligase side products.
Topics: Acetaldehyde; Acetoin; Acetolactate Synthase; Alanine; Aspartic Acid; Catalytic Domain; Circular Dichroism; Decarboxylation; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Kinetics; Lactates; Pyruvate Decarboxylase; Pyruvic Acid; Recombinant Proteins; Saccharomyces cerevisiae; Stereoisomerism; Substrate Specificity | 2001 |
Catalytic acid-base groups in yeast pyruvate decarboxylase. 3. A steady-state kinetic model consistent with the behavior of both wild-type and variant enzymes at all relevant pH values.
Topics: Acetaldehyde; Alanine; Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Catalytic Domain; Computer Simulation; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Pyruvate Decarboxylase; Pyruvates; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity | 2001 |
MK801 decreases glutamate release and oxidative metabolism during hypoglycemic coma in piglets.
Topics: Animals; Aspartic Acid; Brain Chemistry; Cerebrovascular Circulation; Coma; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hypoglycemia; Microdialysis; Neurotoxins; Oxygen; Oxygen Consumption; Receptors, N-Methyl-D-Aspartate; Swine | 2001 |
A Ty1 reverse transcriptase active-site aspartate mutation blocks transposition but not polymerization.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Glutamic Acid; Mutation; Retroelements; RNA-Directed DNA Polymerase; Transcription, Genetic; Yeasts | 2001 |
Involvement of adenosine in the effect of antidepressants on glutamate and aspartate release in the rat prefrontal cortex.
Topics: Adenosine; Animals; Anti-Arrhythmia Agents; Antidepressive Agents; Aspartic Acid; Brain; Caffeine; Glutamic Acid; Male; Microdialysis; Rats; Rats, Wistar; Veratridine | 2001 |
Reversible inactivation of the dorsal nucleus of the lateral lemniscus reveals its role in the processing of multiple sound sources in the inferior colliculus of bats.
Topics: Acoustic Stimulation; Action Potentials; Animals; Aspartic Acid; Auditory Pathways; Auditory Threshold; Bicuculline; Chiroptera; Echolocation; GABA Antagonists; Glutamic Acid; Inferior Colliculi; Iontophoresis; Kynurenic Acid; Neural Inhibition; Neurons; Pons; Reaction Time; Receptors, Glycine; Sound Localization; Strychnine | 2001 |
Characterization of Na+-coupled glutamate/aspartate transport by a rat brain astrocyte line expressing GLAST and EAAC1.
Topics: Alanine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Blotting, Western; Carrier Proteins; Cell Line; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Ganglionic Stimulants; Genistein; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Ionophores; Kainic Acid; Protein Isoforms; Protein-Tyrosine Kinases; Quaternary Ammonium Compounds; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Sodium; Symporters; Telencephalon; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
1H magnetic resonance spectroscopic imaging of permanent focal cerebral ischemia in rat: longitudinal metabolic changes in ischemic core and rim.
Topics: Animals; Aspartic Acid; Biomarkers; Brain Ischemia; Caudate Nucleus; Circle of Willis; Energy Metabolism; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; Ligation; Magnetic Resonance Imaging; Male; Necrosis; Putamen; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Time Factors | 2001 |
Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4.
Topics: Amino Acid Transport System X-AG; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspartic Acid; Drug Synergism; Electric Conductivity; Excitatory Amino Acid Transporter 4; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Ion Channel Gating; Niflumic Acid; Oocytes; Receptors, Glutamate; Substrate Specificity; Symporters; Xenopus laevis | 2001 |
Alternate cadmium exposure differentially affects amino acid metabolism within the hypothalamus, median eminence, striatum and prefrontal cortex of male rats.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Cadmium; Corpus Striatum; Glutamic Acid; Glutamine; Hypothalamus; Male; Median Eminence; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reference Values | 2001 |
Synaptosomal and vesicular accumulation of L-glutamate, L-aspartate and D-aspartate.
Topics: Animals; Aspartic Acid; Binding, Competitive; Glutamic Acid; Kinetics; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism; Synaptic Vesicles; Synaptosomes; Temperature; Time Factors | 2001 |
Ethanol pre-exposure suppresses HIV-1 glycoprotein 120-induced neuronal degeneration by abrogating endogenous glutamate/Ca2+-mediated neurotoxicity.
Topics: AIDS Dementia Complex; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Calcium; Drug Interactions; Ethanol; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; HIV Envelope Protein gp120; Immunohistochemistry; Interleukin-6; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tritium | 2001 |
1H-MR spectroscopic monitoring of posttraumatic metabolism following controlled cortical impact injury: pilot study.
Topics: Animals; Aspartic Acid; Brain Concussion; Brain Edema; Cerebral Cortex; Choline; Creatine; Energy Metabolism; Glutamic Acid; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Pilot Projects; Rats; Rats, Sprague-Dawley | 2000 |
Extracellular glutamate and aspartate in head injured patients.
Topics: Adolescent; Adult; Aspartic Acid; Brain Edema; Brain Injuries; Extracellular Space; Female; Glasgow Outcome Scale; Glutamic Acid; Humans; Male; Microdialysis; Middle Aged; Prognosis | 2000 |
Enzymatic synthesis of chromogenic substrates for Glu,Asp-specific proteinases.
Topics: Anilides; Aspartic Acid; Bacillus; Biochemistry; Chromogenic Compounds; Glutamic Acid; Kinetics; Serine Endopeptidases; Substrate Specificity; Subtilisins | 2001 |
Methylmercury has a selective effect on mitochondria in cultured astrocytes in the presence of [U-(13)C]glutamate.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Carbon Radioisotopes; Cells, Cultured; Cerebral Cortex; Citric Acid Cycle; Energy Metabolism; Glutamic Acid; Glutamine; Glutathione; Mercury Poisoning, Nervous System; Methylmercury Compounds; Mitochondria; Rats; Rats, Sprague-Dawley | 2001 |
Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain.
Topics: Animals; Aspartic Acid; Body Weight; Brain; Cyclosporine; Drug Synergism; Everolimus; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Immunosuppressive Agents; Magnetic Resonance Spectroscopy; Mitochondria; Oxaloacetic Acid; Phosphates; Rats; Rats, Wistar; Sirolimus; Weight Gain | 2001 |
High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging.
Topics: Alanine; Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Ethanolamines; Female; Glioma; Glucose; Glutamic Acid; Glutamine; Glycolysis; Lactic Acid; Magnetic Resonance Imaging; Phosphocreatine; Rats; Rats, Sprague-Dawley; Taurine; Tumor Cells, Cultured | 2001 |
Comparison between hypothermia and glutamate antagonism treatments on the immediate outcome of perinatal asphyxia.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Aspartic Acid; Asphyxia Neonatorum; Behavior, Animal; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Kidney; Lactic Acid; Maternal Behavior; Microdialysis; Pyruvic Acid; Quinoxalines; Rats; Receptors, Glutamate; Survival Rate; Treatment Outcome | 2001 |
Serotonin depletion produces long lasting increase in striatal glutamatergic transmission.
Topics: 5,7-Dihydroxytryptamine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Corpus Striatum; Dopamine; Excitatory Amino Acids; Extracellular Space; Female; Glutamic Acid; Glutamine; Hydroxyindoleacetic Acid; In Situ Hybridization; Microdialysis; Microinjections; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Serotonin Agents; Synaptic Transmission; Synaptosomes; Transcription, Genetic | 2001 |
Geochemical evolution of amino acids in dentine of Pleistocene bears.
Topics: Age Determination by Teeth; Algorithms; Animals; Aspartic Acid; Dentin; Evolution, Molecular; Fossils; Glutamic Acid; Kinetics; Models, Biological; Models, Chemical; Stereoisomerism; Ursidae | 2001 |
Prenatal exposure to methyl mercury in rats: focus on changes in kynurenine pathway.
Topics: Animals; Aspartic Acid; Female; Fetus; Glutamic Acid; Hippocampus; Kynurenine; Mercury Poisoning, Nervous System; Methylmercury Compounds; Neurons; ortho-Aminobenzoates; Pregnancy; Prenatal Exposure Delayed Effects; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 2001 |
The factor VII zymogen structure reveals reregistration of beta strands during activation.
Topics: Aspartic Acid; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Enzyme Precursors; Factor VII; Glutamic Acid; Isoleucine; Models, Molecular; Protein Conformation; Recombinant Proteins; Thromboplastin | 2001 |
A critical view on conservative mutations.
Topics: Amino Acid Sequence; Aspartic Acid; Glutamic Acid; Ions; Models, Molecular; Mutation; Protein Conformation; Sequence Homology, Amino Acid; Solvents; Static Electricity | 2001 |
Volume correction for edema in single-volume proton MR spectroscopy of contrast-enhancing multiple sclerosis lesions.
Topics: Adult; Aspartic Acid; Brain; Case-Control Studies; Choline; Contrast Media; Creatine; Edema; Female; Gadolinium DTPA; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Regression Analysis; Signal Processing, Computer-Assisted | 2001 |
Restoration of motion-related signal loss and line-shape deterioration of proton MR spectra using the residual water as intrinsic reference.
Topics: Aspartic Acid; Brain; Choline; Creatinine; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Movement; Phantoms, Imaging; Protons; Signal Processing, Computer-Assisted; Water | 2001 |
Effects of ENA713 and CHF2819, two anti-Alzheimer's disease drugs, on rat amino acid levels.
Topics: Alzheimer Disease; Animals; Arginine; Aspartic Acid; Carbamates; Cholinesterase Inhibitors; Citrulline; Cyclic N-Oxides; Dose-Response Relationship, Drug; Excitatory Amino Acids; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Neurons; Phenylcarbamates; Rats; Rats, Wistar; Rivastigmine; Synaptic Transmission; Taurine | 2001 |
A program of Yersinia enterocolitica type III secretion reactions is activated by specific signals.
Topics: Albumins; Asparagine; Aspartic Acid; Bacterial Outer Membrane Proteins; Calcium; Genes, Regulator; Glutamic Acid; Glutamine; HeLa Cells; Humans; Mutation; Signal Transduction; Yersinia enterocolitica | 2001 |
[Proton magnetic-resonance spectroscopy in remitting and secondary-progressive multiple sclerosis].
Topics: Adolescent; Adult; Aspartic Acid; Brain; Choline; Creatine; Demyelinating Diseases; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Phosphocreatine; Severity of Illness Index | 2001 |
Effect of acute exposure to ammonia on glutamate transport in glial cells isolated from the salamander retina.
Topics: Amino Acid Transport System X-AG; Ammonia; Animals; Anions; Aspartic Acid; ATP-Binding Cassette Transporters; Cell Separation; Glutamate-Ammonia Ligase; Glutamic Acid; Hydrogen-Ion Concentration; Ion Channel Gating; Membrane Potentials; Methionine Sulfoximine; Neuroglia; Patch-Clamp Techniques; Potassium; Quaternary Ammonium Compounds; Retina; Sodium; Urodela | 2001 |
[Melatonin decreases the release of amino acid transmitters in hypoxic rat cortical slice].
Topics: Animals; Aspartic Acid; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acids; Glutamic Acid; Male; Melatonin; Random Allocation; Rats; Rats, Sprague-Dawley | 1999 |
Detection of release of aspartate and glutamate in cat spinal dorsal horn following noxious stimulation of cutaneous and muscular afferent fibers using microdialysis.
Topics: Animals; Aspartic Acid; Cats; Efferent Pathways; Glutamic Acid; Microdialysis; Muscle, Skeletal; Nociceptors; Posterior Horn Cells; Skin; Spinal Cord | 1999 |
beta-Ketoacyl-[acyl carrier protein] synthase I of Escherichia coli: aspects of the condensation mechanism revealed by analyses of mutations in the active site pocket.
Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; Aspartic Acid; Binding Sites; Carboxy-Lyases; Catalysis; Chromatography; Cysteine; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutamic Acid; Glutamine; Histidine; Hydrogen-Ion Concentration; Isoenzymes; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Myristic Acid; Plasmids; Protein Binding; Recombinant Proteins | 2001 |
Regulation of glutamate transport and transport proteins in a placental cell line.
Topics: Amino Acid Transport System X-AG; Amino Acids; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; beta-Alanine; Biological Transport; Biotinylation; Carrier Proteins; Cell Line; Cell Membrane; Choline; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Female; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutamine; Homeostasis; Humans; Kinetics; Leucine; Placenta; Pregnancy; Rats; Symporters | 2001 |
Chiral analysis of UV nonabsorbing compounds by capillary electrophoresis using macrocyclic antibiotics: 1. Separation of aspartic and glutamic acid enantiomers.
Topics: Anti-Bacterial Agents; Aspartic Acid; Beer; Dentin; Electrophoresis, Capillary; Glutamic Acid; Humans; Spectrophotometry, Ultraviolet; Stereoisomerism; Teicoplanin; Vancomycin | 2001 |
Interconversion of (S)-glutamate and (2S,3S)-3-methylaspartate: a distinctive B(12)-dependent carbon-skeleton rearrangement.
Topics: Aspartic Acid; Catalysis; Clostridium; Cobamides; Deoxyadenosines; Electron Spin Resonance Spectroscopy; Glutamic Acid; Glycine; Hydrogen; Intramolecular Transferases; Methylmalonyl-CoA Mutase; Models, Chemical; Molecular Structure; Oxidation-Reduction; Propylamines; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2001 |
Evidence for two mechanisms of amino acid osmolyte release from hippocampal slices.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Androstadienes; Angiogenesis Inhibitors; Animals; Aspartic Acid; Cyclooxygenase Inhibitors; Cytochalasins; Enzyme Inhibitors; Flavonoids; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Imidazoles; In Vitro Techniques; Mitogen-Activated Protein Kinases; Niflumic Acid; Nitrobenzoates; Osmolar Concentration; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyridines; Rats; Taurine; Tritium; Tyrphostins; Wortmannin | 2001 |
Thermodynamics of HMGB1 interaction with duplex DNA.
Topics: Aspartic Acid; Base Pairing; Base Sequence; Binding Sites; Calorimetry; Cloning, Molecular; DNA; Glutamic Acid; High Mobility Group Proteins; Kinetics; Models, Molecular; Nucleic Acid Conformation; Poly dA-dT; Polydeoxyribonucleotides; Protein Conformation; Recombinant Proteins; Repetitive Sequences, Amino Acid; Thermodynamics | 2001 |
Stabilization of a fibronectin type III domain by the removal of unfavorable electrostatic interactions on the protein surface.
Topics: Amino Acid Sequence; Aspartic Acid; Cloning, Molecular; Escherichia coli; Fibronectins; Glutamic Acid; Hot Temperature; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Conformation; Protein Denaturation; Protein Structure, Secondary; Recombinant Proteins; Static Electricity; Surface Properties; Thermodynamics | 2001 |
TCA cycle kinetics in the rat heart by analysis of (13)C isotopomers using indirect (1)H.
Topics: Acetic Acid; Aminooxyacetic Acid; Animals; Aspartic Acid; Carbon Isotopes; Citric Acid Cycle; Enzyme Inhibitors; Glutamic Acid; Heart; In Vitro Techniques; Kinetics; Magnetic Resonance Spectroscopy; Malates; Models, Biological; Myocardium; Perfusion; Propionates; Rats; Transaminases | 2001 |
Activation of carrier-mediated transport of L-cystine at the blood-brain and blood-retinal barriers in vivo.
Topics: 2-Aminoadipic Acid; Animals; Aspartic Acid; Biological Transport; Blood-Brain Barrier; Blood-Retinal Barrier; Cystine; Glutamic Acid; Male; Maleates; Rats; Rats, Wistar | 2001 |
[Features of neurotransmitter pool in cerebrospinal fluid of patients with epilepsy].
Topics: Adult; Aspartic Acid; Brain; Epilepsy; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Neurotransmitter Agents; Severity of Illness Index; Taurine | 2001 |
Stimulation of glutamate, aspartate and gamma-aminobutyric acid release from synaptosomes by hyperforin.
Topics: Adenosine Triphosphate; Animals; Antipsychotic Agents; Aspartic Acid; Bridged Bicyclo Compounds; Calcium; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Hydrogen-Ion Concentration; Male; Neurotransmitter Agents; Phloroglucinol; Potassium Chloride; Rats; Rats, Sprague-Dawley; Reserpine; Synaptosomes; Terpenes; Veratridine | 2001 |
Kinetics and activation of postsynaptic kainate receptors at thalamocortical synapses: role of glutamate clearance.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Central Nervous System Stimulants; Cerebral Cortex; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kainic Acid; Kinetics; Organ Culture Techniques; Picrotoxin; Rats; Rats, Wistar; Receptors, Kainic Acid; Synapses; Synaptic Transmission; Temperature; Thalamus | 2001 |
Catalysis of the oligomerization of O-phospho-serine, aspartic acid, or glutamic acid by cationic micelles.
Topics: Amino Acids; Aspartic Acid; Catalysis; Cetrimonium; Cetrimonium Compounds; Evolution, Molecular; Glutamic Acid; Hydrogen-Ion Concentration; Imidazoles; Micelles; Oligopeptides; Phosphoserine | 1996 |
Oligomerization of negatively-charged amino acids by carbonyldiimidazole.
Topics: Aspartic Acid; Catalysis; Evolution, Chemical; Glutamic Acid; Imidazoles; Magnesium; Phosphoserine; Polymers; Temperature | 1996 |
Determination of free intracellular amino acids in single mouse peritoneal macrophages after naphthalene-2,3-dicarboxaldehyde derivatization by capillary zone electrophoresis with electrochemical detection.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cell Extracts; Electrochemistry; Electrophoresis, Capillary; Glutamic Acid; Glycine; Intracellular Fluid; Macrophages, Peritoneal; Mice; Naphthalenes; Serine; Taurine | 2001 |
Neuronal glutamate transporters control activation of postsynaptic metabotropic glutamate receptors and influence cerebellar long-term depression.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Benzoates; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Glycine; Long-Term Potentiation; Nerve Fibers; Neural Inhibition; Organ Culture Techniques; Picrotoxin; Purkinje Cells; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Synapses; Tetrodotoxin | 2001 |
Glomerulus-specific synchronization of mitral cells in the olfactory bulb.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kinetics; N-Methylaspartate; Olfactory Bulb; Olfactory Receptor Neurons; Periodicity; Quinoxalines; Rats; Rats, Sprague-Dawley; Smell | 2001 |
Differential perturbation of neuronal and glial glutamate transport systems in retinal ischaemia.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport, Active; Electroretinography; Female; Glutamic Acid; Immunohistochemistry; Ischemia; Neuroglia; Neurons; Perfusion; Rats; Retina; Retinal Vessels | 2001 |
Substitution of aspartate and glutamate for active center histidines in the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system maintain phosphotransfer potential.
Topics: Aspartic Acid; Bacterial Proteins; Escherichia coli; Glutamic Acid; Histidine; Phosphoenolpyruvate Sugar Phosphotransferase System; Phosphorylation; Structure-Activity Relationship | 2001 |
Differentiation-associated Na+-dependent inorganic phosphate cotransporter (DNPI) is a vesicular glutamate transporter in endocrine glutamatergic systems.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Biological Transport; Blotting, Northern; Calcium; Carrier Proteins; Cell Differentiation; Cells, Cultured; COS Cells; DNA, Complementary; Glutamic Acid; Glutamine; Immunoblotting; Immunohistochemistry; Islets of Langerhans; Male; Membrane Transport Proteins; Neurons; Pineal Gland; Protein Binding; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sodium; Vesicular Glutamate Transport Protein 2; Vesicular Transport Proteins | 2001 |
Structural and functional characterization of human CXCR4 as a chemokine receptor and HIV-1 co-receptor by mutagenesis and molecular modeling studies.
Topics: Aspartic Acid; Calcium; Cell Line; Chemokines; Flow Cytometry; Genes, Reporter; Glutamic Acid; HIV-1; Humans; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, CXCR4; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; Structure-Activity Relationship; Tyrosine | 2001 |
Hydrophobic amino acid residues in the acceptor binding site are main determinants for reaction mechanism and specificity of cyclodextrin-glycosyltransferase.
Topics: Amino Acids; Aspartic Acid; beta-Cyclodextrins; Binding Sites; Cyclodextrins; Dose-Response Relationship, Drug; Escherichia coli; Glucosyltransferases; Glutamic Acid; Histidine; Hydrolysis; Kinetics; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Plasmids; Protein Binding; Protein Conformation; Substrate Specificity; Water | 2001 |
The distal hinge of the reactive site loop and its proximity: a target to modulate plasminogen activator inhibitor-1 activity.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Arginine; Aspartic Acid; Binding Sites; DNA; Epitopes; Glutamic Acid; Histidine; Humans; Kinetics; Lysine; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Plasminogen Activator Inhibitor 1; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Rats; Sequence Homology, Amino Acid; Surface Plasmon Resonance; Swine; Time Factors | 2001 |
N-acetylaspartylglutamate (NAAG) is the probable mediator of axon-to-glia signaling in the crayfish medial giant nerve fiber.
Topics: Animals; Aspartic Acid; Astacoidea; Axons; Carboxypeptidases; Cell Communication; Cysteic Acid; Dipeptides; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate Carboxypeptidase II; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Nervous System; Neuroglia; Organophosphorus Compounds; Receptors, Glutamate; Signal Transduction; Time Factors | 2001 |
Synthesis and release of N-acetylaspartylglutamate (NAAG) by crayfish nerve fibers: implications for axon-glia signaling.
Topics: Animals; Aspartic Acid; Astacoidea; Axons; Carbon Radioisotopes; Carboxypeptidases; Cell Communication; Culture Media; Cytoplasm; Dipeptides; Electric Stimulation; gamma-Aminobutyric Acid; Glutamate Carboxypeptidase II; Glutamic Acid; Glutamine; Nervous System; Neuroglia; Organ Culture Techniques; Quisqualic Acid; Signal Transduction; Tritium | 2001 |
The role of a beta-bulge in the folding of the beta-hairpin structure in ubiquitin.
Topics: Amino Acid Substitution; Aspartic Acid; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Peptides; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Tertiary; Spectrometry, Fluorescence; Titrimetry; Ubiquitin | 2001 |
Effects of sevoflurane on dopamine, glutamate and aspartate release in an in vitro model of cerebral ischaemia.
Topics: Anesthetics, Inhalation; Animals; Aspartic Acid; Brain Ischemia; Corpus Striatum; Culture Techniques; Dopamine; Glutamic Acid; Male; Methyl Ethers; Neurotransmitter Agents; Rats; Rats, Wistar; Sevoflurane | 2001 |
Brain amino acid metabolism and ketosis.
Topics: Amino Acids; Animals; Aspartic Acid; Blood-Brain Barrier; Body Weight; Brain; Coenzyme A; Dietary Fats; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Glucose; Glutamic Acid; Ketone Bodies; Ketosis; Male; Mice; Nerve Tissue Proteins; Prosencephalon | 2001 |
Impaired glutamate uptake in the R6 Huntington's disease transgenic mice.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Biological Transport; Carrier Proteins; Cerebral Cortex; Corpus Striatum; Crosses, Genetic; Disease Models, Animal; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glial Fibrillary Acidic Protein; Glutamate Plasma Membrane Transport Proteins; Glutamate-Ammonia Ligase; Glutamic Acid; Humans; Huntingtin Protein; Huntington Disease; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Models, Neurological; Nerve Tissue Proteins; Nuclear Proteins; Peptides; Phenotype; RNA, Messenger; Symporters | 2001 |
Taurine-, aspartate- and glutamate-like immunoreactivity identifies chemically distinct subdivisions of Kenyon cells in the cockroach mushroom body.
Topics: Aging; Animals; Antibody Specificity; Aspartic Acid; Axons; Body Patterning; Brain; Cell Size; Excitatory Amino Acids; Fluorescent Antibody Technique; Glutamic Acid; Growth Cones; Larva; Microscopy, Confocal; Mushroom Bodies; Neurotransmitter Agents; Nymph; Periplaneta; Taurine | 2001 |
Negative ion fragmentations of deprotonated peptides: backbone cleavages directed through both Asp and Glu.
Topics: Amino Acid Sequence; Animals; Anura; Aspartic Acid; Elementary Particle Interactions; Glutamic Acid; Ions; Mass Spectrometry; Molecular Sequence Data; Peptides; Spectrometry, Mass, Fast Atom Bombardment | 2001 |
Glu375Gln and Asp225Val mutants: about the nature of the covalent linkages between heme group and apo-Protein in bovine lactoperoxidase.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Base Sequence; Blotting, Western; Cattle; CHO Cells; Cricetinae; DNA Primers; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Glutamic Acid; Glycine; Heme; Lactoperoxidase; Mutation; Valine | 2001 |
Dehydration is catalyzed by glutamate-136 and aspartic acid-135 active site residues in Escherichia coli dTDP-glucose 4,6-dehydratase.
Topics: Aspartic Acid; Binding Sites; Catalysis; Deoxyglucose; Escherichia coli; Glutamic Acid; Hydro-Lyases; Hydrogen; Hydrogen-Ion Concentration; Kinetics; Protons; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity | 2001 |
[Preparation, characterization and characteristics of copolypeptide consisting of L-aspartic acid and L-glutamic acid].
Topics: Animals; Aspartic Acid; Biocompatible Materials; Dipeptides; Glutamic Acid; Peptides; Polyglutamic Acid; Rats; Surface Properties | 2001 |
Brain excitatory amino acid concentrations are lower in the neonatal pig: a buffer against excitotoxicity?
Topics: Animals; Animals, Newborn; Aspartic Acid; Blood Pressure; Brain; Brain Chemistry; Electroencephalography; Excitatory Amino Acids; Glutamic Acid; Hypoglycemia; Insulin; Insulin Coma; Microdialysis; Oxygen; Swine | 2001 |
Synthesis and biochemical characterization of a phosphorylated analogue of the response regulator CheB.
Topics: Aspartic Acid; Bacterial Proteins; Catalytic Domain; Chromatography, High Pressure Liquid; Cysteine; Escherichia coli; Esterases; Glutamic Acid; Glutamine; Magnesium; Mass Spectrometry; Methylation; Models, Chemical; Mutagenesis, Site-Directed; Mutation; Phosphates; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Signal Transduction; Time Factors | 2001 |
GABA, taurine and learning: release of amino acids from slices of chick brain following filial imprinting.
Topics: Animals; Animals, Newborn; Arginine; Aspartic Acid; Behavior, Animal; Calcium; Cell Membrane; Chickens; Chromatography, High Pressure Liquid; Citrulline; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Imprinting, Psychological; Membrane Potentials; Neurons; Neuropsychological Tests; Potassium Chloride; Taurine; Telencephalon | 2001 |
Taurine selectively modulates the secretory activity of vasopressin neurons in conscious rats.
Topics: Action Potentials; Animals; Aspartic Acid; Benzothiadiazines; Bicuculline; Consciousness; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Neural Inhibition; Neurons; Oxytocin; Rats; Rats, Wistar; Receptors, GABA-A; Stress, Physiological; Supraoptic Nucleus; Swimming; Taurine; Vasopressins | 2001 |
Characterization and biological activities of Chenopodium leaf hemagglutinin (CLH).
Topics: Amino Acids; Animals; Aspartic Acid; Cell Aggregation; Chenopodium; Dose-Response Relationship, Drug; Erythrocytes; Glutamic Acid; Glycine; Hemagglutinins; Lysine; Methionine; Mice; Phenylalanine; Plant Leaves; Rabbits; Rats; Spleen; Thymus Gland; Tryptophan | 2001 |
Achieving large color changes in response to the presence of amino acids: a molecular sensing ensemble with selectivity for aspartate.
Topics: Aspartic Acid; Benzenesulfonates; Colorimetry; Coloring Agents; Glutamic Acid; Kinetics; Organometallic Compounds; Pyridines; Substrate Specificity; Zinc | 2001 |
Crystal structure of quinohemoprotein amine dehydrogenase from Pseudomonas putida. Identification of a novel quinone cofactor encaged by multiple thioether cross-bridges.
Topics: Amino Acids; Aspartic Acid; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Cysteine; Dipeptides; Glutamic Acid; Indolequinones; Models, Molecular; Oxidoreductases Acting on CH-NH Group Donors; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Pseudomonas putida; Quinones; Sulfides | 2002 |
Regulation of phototransduction in short-wavelength cone visual pigments via the retinylidene Schiff base counterion.
Topics: Animals; Aspartic Acid; Cattle; COS Cells; Glutamic Acid; Glutamine; Mutagenesis, Site-Directed; Protons; Retinal Cone Photoreceptor Cells; Retinaldehyde; Retinoids; Rod Opsins; Schiff Bases; Spectrophotometry, Ultraviolet; Static Electricity; Vision, Ocular; Xenopus | 2001 |
Simultaneous replacement of Asp-L210 and Asp-M17 with Asn increases proton uptake by Glu-L212 upon first electron transfer to QB in reaction centers from Rhodobacter sphaeroides.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Deuterium Oxide; Electron Transport; Glutamic Acid; Glutamine; Mutagenesis, Site-Directed; Photosynthetic Reaction Center Complex Proteins; Protons; Quinones; Rhodobacter sphaeroides; Spectroscopy, Fourier Transform Infrared | 2001 |
Purification of kinase activity from primate parotid glands.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Chromatography, Affinity; Enzyme Inhibitors; Enzymes, Immobilized; Glutamic Acid; Glycoproteins; Golgi Apparatus; Guanosine Triphosphate; Heparin; Histatins; Hydrogen-Ion Concentration; Macaca fascicularis; Parotid Gland; Phosphopeptides; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Salivary Proteins and Peptides; Serine; Substrate Specificity | 2001 |
GABA release induced by aspartate-mediated activation of NMDA receptors is modulated by dopamine in a selective subpopulation of amacrine cells.
Topics: Amacrine Cells; Animals; Aspartic Acid; Carrier Proteins; Cell Survival; Chickens; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Immunohistochemistry; Isoenzymes; Kainic Acid; L-Lactate Dehydrogenase; Membrane Proteins; Membrane Transport Proteins; N-Methylaspartate; Organic Anion Transporters; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2001 |
Striatal neuronal loss or dysfunction and choline rise in children with attention-deficit hyperactivity disorder: a 1H-magnetic resonance spectroscopy study.
Topics: Adolescent; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Cell Death; Child; Choline; Corpus Striatum; Creatine; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Neurons | 2001 |
Determination of active site residues in Escherichia coli endonuclease VIII.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Deoxyribonuclease (Pyrimidine Dimer); DNA Primers; Dose-Response Relationship, Drug; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Kinetics; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxygen; Plasmids; Proline; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Thymine; Uracil | 2002 |
Beta-amyloid fibrils activate the C1 complex of complement under physiological conditions: evidence for a binding site for A beta on the C1q globular regions.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Asparagine; Aspartic Acid; Binding Sites; Complement C1; Complement C1q; Complement Pathway, Classical; Glutamic Acid; Glutamine; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Peptide Fragments; Protein Structure, Tertiary; Rats | 2001 |
Two novel prevalent polymorphisms in the hormone-sensitive lipase gene have no effect on insulin sensitivity of lipolysis and glucose disposal.
Topics: Adult; Alleles; Aspartic Acid; Blood Glucose; Exons; Fatty Acids, Nonesterified; Female; Glucose Clamp Technique; Glutamic Acid; Glycerol; Humans; Insulin; Insulin Resistance; Isoleucine; Kinetics; Lipolysis; Male; Mutation; Obesity; Polymorphism, Genetic; Regulatory Sequences, Nucleic Acid; Sequence Analysis, DNA; Serine; Sterol Esterase; Triglycerides | 2001 |
Effects of charged amino-acid mutation on the solution structure of cytochrome b(5) and binding between cytochrome b(5) and cytochrome c.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cattle; Crystallography, X-Ray; Cytochrome c Group; Cytochromes b5; Dose-Response Relationship, Drug; Glutamic Acid; Horses; Hydrogen-Ion Concentration; Liver; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Mutation; Myocardium; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Sequence Homology, Amino Acid | 2001 |
Involvement of metabotropic glutamate receptors in excitatory amino acid and GABA release following spinal cord injury in rat.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord; Spinal Cord Injuries | 2001 |
Conserved negatively charged residues are not required for ATP action at P2X(1) receptors.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Aspartic Acid; Biotinylation; Cell Membrane; Conserved Sequence; Dose-Response Relationship, Drug; Electric Conductivity; Glutamic Acid; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Receptors, Purinergic P2; Receptors, Purinergic P2X; Sequence Homology, Amino Acid; Xenopus | 2001 |
Effects of pentylenetetrazole and glutamate on metabolism of [U-(13)C]glucose in cultured cerebellar granule neurons.
Topics: Alanine; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Convulsants; Glucose; Glutamic Acid; Lactates; Magnetic Resonance Spectroscopy; Mice; Neurons; Pentylenetetrazole | 2002 |
The acute effect of valproate on cerebral energy metabolism in mice.
Topics: Acetates; Adenosine Triphosphate; Animals; Anticonvulsants; Aspartic Acid; Brain; Citric Acid Cycle; Energy Metabolism; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred ICR; Phosphocreatine; Valproic Acid | 2001 |
Differences in neurotransmitter synthesis and intermediary metabolism between glutamatergic and GABAergic neurons during 4 hours of middle cerebral artery occlusion in the rat: the role of astrocytes in neuronal survival.
Topics: Acetate-CoA Ligase; Alanine; Anesthetics, Inhalation; Animals; Aspartic Acid; Astrocytes; Blood Glucose; Carbon Isotopes; Cell Communication; Cell Survival; Citric Acid Cycle; Energy Metabolism; Frontal Lobe; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Infarction, Middle Cerebral Artery; Isoflurane; Magnetic Resonance Spectroscopy; Male; Neostriatum; Neurons; Parietal Lobe; Rats; Rats, Wistar | 2001 |
In-vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism.
Topics: Adult; Aspartic Acid; Endothelium, Vascular; F2-Isoprostanes; Female; Forearm; Genotype; Glutamic Acid; Hand; Homozygote; Humans; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Polymorphism, Single Nucleotide; Regional Blood Flow; Vascular Resistance; Vasodilation | 2001 |
Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis.
Topics: Aldose-Ketose Isomerases; Aspartic Acid; Binding Sites; Cations; Cloning, Molecular; Crystallography, X-Ray; Dimerization; Escherichia coli; Glutamic Acid; Ligands; Models, Chemical; Models, Molecular; Multienzyme Complexes; Oxidoreductases; Polyisoprenyl Phosphates; Protein Binding; Protein Conformation; Protein Structure, Quaternary; Protein Structure, Tertiary | 2002 |
Identification of the active site of poly(A)-specific ribonuclease by site-directed mutagenesis and Fe(2+)-mediated cleavage.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Binding Sites; Exoribonucleases; Glutamic Acid; Humans; Iron; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Proteins | 2002 |
N-terminal contributions of the gamma-subunit of fetal hemoglobin to its tetramer strength: remote effects at subunit contacts.
Topics: Amino Acid Sequence; Aspartic Acid; Circular Dichroism; Dimerization; Dose-Response Relationship, Drug; Fetal Hemoglobin; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Isoelectric Focusing; Isoleucine; Kinetics; Leucine; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oxygen; Phenylalanine; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Valine | 2002 |
Extracellular glutamate, aspartate and arginine increase in the ventral posterolateral thalamic nucleus during nociceptive stimulation.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Electrophoresis, Capillary; Extracellular Space; Glutamic Acid; Male; Microdialysis; Nociceptors; Pain; Pain Measurement; Rats; Rats, Wistar; Synaptic Transmission; Ventral Thalamic Nuclei | 2001 |
Detection of a [3Fe-4S] cluster intermediate of cytosolic aconitase in yeast expressing iron regulatory protein 1. Insights into the mechanism of Fe-S cluster cycling.
Topics: Aconitate Hydratase; Aspartic Acid; Cell Division; Cytoplasm; Cytosol; Electron Spin Resonance Spectroscopy; Glutamic Acid; Hydrogen Peroxide; Iron; Iron Regulatory Protein 1; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Mutation; Oxygen; Phosphorylation; Reactive Oxygen Species; RNA-Binding Proteins; Saccharomyces cerevisiae; Serine; Time Factors | 2002 |
Hydrogen turnover and subcellular compartmentation of hepatic [2-(13)C]glutamate and [3-(13)C]aspartate as detected by (13)C NMR.
Topics: Animals; Aspartic Acid; Citric Acid Cycle; Cytosol; Glutamic Acid; Hydrogen; Kinetics; Liver; Magnetic Resonance Spectroscopy; Male; Mice; Mitochondria; Models, Biological; Models, Chemical; Perfusion; Protein Binding; Time Factors; Water | 2002 |
Effect of glutamine and GABA on [U-(13)C]glutamate metabolism in cerebellar astrocytes and granule neurons.
Topics: Animals; Aspartic Acid; Astrocytes; Carbon Radioisotopes; Cell Extracts; Cells, Cultured; Cerebellum; Citric Acid Cycle; Drug Interactions; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Mice; Neurons; Synaptic Transmission | 2001 |
In vivo cellular uptake of glutamate is impaired in the rat hippocampus during and after transient cerebral ischemia: a microdialysis extraction study.
Topics: Animals; Aspartic Acid; Brain Ischemia; Carrier Proteins; Enzyme Inhibitors; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Nerve Degeneration; Presynaptic Terminals; Rats; Rats, Wistar; Synaptic Transmission; Tritium | 2001 |
Atmospheric pressure matrix-assisted laser desorption/ionization ion trap mass spectrometry of sulfonic acid derivatized tryptic peptides.
Topics: Amino Acid Sequence; Aspartic Acid; Atmospheric Pressure; Electrophoresis, Gel, Two-Dimensional; Fibrinogen; Glutamic Acid; Ions; Methionine; Molecular Sequence Data; Oxidation-Reduction; Peptide Fragments; Proline; Reproducibility of Results; Sequence Analysis, Protein; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfonic Acids | 2001 |
Residues 137 and 153 at the N terminus of the XylS protein influence the effector profile of this transcriptional regulator and the sigma factor used by RNA polymerase to stimulate transcription from its cognate promoter.
Topics: Amino Acids; Asparagine; Aspartic Acid; Bacterial Proteins; beta-Galactosidase; DNA; DNA-Binding Proteins; DNA-Directed RNA Polymerases; Escherichia coli; Glutamic Acid; Histidine; Mutation; Plasmids; Point Mutation; Promoter Regions, Genetic; Protein Structure, Tertiary; RNA; Trans-Activators; Transcription, Genetic | 2002 |
Differing effects of substrate and non-substrate transport inhibitors on glutamate uptake reversal.
Topics: Adenosine Triphosphate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Biological Transport; Carrier Proteins; Cells, Cultured; Dicarboxylic Acids; Glutamic Acid; Kainic Acid; Mice; Nerve Tissue Proteins; Neurons; Prosencephalon; Pyrrolidines; Substrate Specificity | 2001 |
Crystallization and preliminary crystallographic studies of five crystal forms of Escherichia coli L-asparaginase II (Asp90Glu mutant).
Topics: Asparaginase; Aspartic Acid; Crystallization; Crystallography, X-Ray; Escherichia coli; Glutamic Acid; Mutation; Protein Conformation | 2002 |
The role of the active site glutamate in the rearrangement of glutamate to 3-methylaspartate catalyzed by adenosylcobalamin-dependent glutamate mutase.
Topics: Aspartic Acid; Binding Sites; Catalysis; Cobamides; Glutamic Acid; Intramolecular Transferases; Kinetics; Mutation; Substrate Specificity | 2001 |
Asp-225 and glu-375 in autocatalytic attachment of the prosthetic heme group of lactoperoxidase.
Topics: Animals; Aspartic Acid; Binding Sites; Catalysis; Cattle; Cell Line; Chromatography, High Pressure Liquid; Cloning, Molecular; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Heme; Hydrogen Peroxide; Hydrogen-Ion Concentration; Insecta; Iron; Lactoperoxidase; Models, Chemical; Models, Molecular; Mutation; Porphyrins; Protein Conformation; Protoporphyrins; Recombinant Proteins; Spectrophotometry | 2002 |
Enantiomeric crystallization from DL-aspartic and DL-glutamic acids: implications for biomolecular chirality in the origin of life.
Topics: Aspartic Acid; Crystallization; Glutamic Acid; Origin of Life; Stereoisomerism | 2001 |
Two glutamate residues, Glu 208 alpha and Glu 197 beta, are crucial for phosphorylation and dephosphorylation of the active-site histidine residue in succinyl-CoA synthetase.
Topics: Adenosine; Alanine; Aspartic Acid; Binding Sites; Catalysis; Crystallography, X-Ray; Dimerization; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutamic Acid; Histidine; Hydrogen Bonding; Kinetics; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Phosphorylation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Succinate-CoA Ligases; Time Factors | 2002 |
Molecular phenotyping of retinal ganglion cells.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Count; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Image Cytometry; Immunohistochemistry; In Vitro Techniques; Male; Phenotype; Rabbits; Receptors, Glutamate; Retinal Ganglion Cells; Signal Transduction; Taurine | 2002 |
Taurine, glutamine, glutamate, and aspartate content and efflux, and cell volume of cerebrocortical minislices of rats with hepatic encephalopathy: influence of ammonia.
Topics: Ammonia; Animals; Aspartic Acid; Cell Size; Cerebral Cortex; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Rats; Rats, Wistar; Taurine | 2000 |
Chimaeric gonadotropin-releasing hormone (GnRH) peptides with improved affinity for the catfish (Clarias gariepinus) GnRH receptor.
Topics: Alanine; Animals; Aspartic Acid; Binding Sites; Catfishes; Cell Line; Cell Membrane; Chickens; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glutamic Acid; Gonadotropin-Releasing Hormone; Humans; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Peptides; Protein Binding; Protein Structure, Tertiary; Receptors, LHRH; Recombinant Fusion Proteins; Transfection; Tryptophan; Tyrosine | 2002 |
S2' substrate specificity and the role of His110 and His111 in the exopeptidase activity of human cathepsin B.
Topics: Amidohydrolases; Aspartic Acid; Binding Sites; Cathepsin B; Exopeptidases; Glutamic Acid; Histidine; Humans; Ions; Kinetics; Lysosomes; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Substrate Specificity; Tolbutamide | 2002 |
The function of Asp70, Glu77 and Lys79 in the Escherichia coli MutH protein.
Topics: Adenosine Triphosphatases; Amino Acid Substitution; Aspartic Acid; Bacterial Proteins; Base Sequence; Binding Sites; Catalysis; DNA; DNA Repair Enzymes; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Genetic Complementation Test; Glutamic Acid; Lysine; Models, Molecular; Mutation; MutL Proteins; Protein Binding; Protein Conformation; Recombinant Fusion Proteins; Structure-Activity Relationship; Thermodynamics | 2002 |
Importance of Na,K-ATPase residue alpha 1-Arg544 in the segment Arg544-Asp567 for high-affinity binding of ATP, ADP, or MgATP.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine; Amino Acid Substitution; Animals; Arginine; Asparagine; Aspartic Acid; Binding Sites; Conserved Sequence; Cysteine; Glutamic Acid; Magnesium; Mutagenesis, Site-Directed; Peptide Fragments; Phosphorylation; Saccharomyces cerevisiae; Serine; Sodium-Potassium-Exchanging ATPase; Swine; Thermodynamics | 2002 |
Alterations in brain metabolism, CNS morphology and CSF dynamics in adult rats with kaolin-induced hydrocephalus.
Topics: Age Factors; Animals; Aspartic Acid; Brain; Cerebrospinal Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Hydrocephalus; Intracranial Pressure; Kaolin; Rats; Rats, Sprague-Dawley; Syringomyelia | 2002 |
Modifier effect of ENOS in autosomal dominant polycystic kidney disease.
Topics: Age of Onset; Aspartic Acid; Belgium; Female; France; Glutamic Acid; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polycystic Kidney, Autosomal Dominant; Polymorphism, Genetic; Renal Artery | 2002 |
Aortic leucine-to-glutamate pathway: metabolic route and regulation of contractile responses.
Topics: Animals; Aorta; Aspartic Acid; Carbon Dioxide; Endothelium, Vascular; Glutamic Acid; In Vitro Techniques; Kinetics; Leucine; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Signal Transduction | 2002 |
Dansyl-PQRamide, a possible neuropeptide FF receptor antagonist, induces conditioned place preference.
Topics: Animals; Aspartic Acid; Conditioning, Psychological; Drug Interactions; gamma-Aminobutyric Acid; Glutamic Acid; Male; Models, Animal; Naloxone; Narcotic Antagonists; Neuropeptides; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide | 2002 |
In vivo monitoring of amino acids by direct sampling of brain extracellular fluid at ultralow flow rates and capillary electrophoresis.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Electrophoresis, Capillary; Ethanolamines; Extracellular Space; Fluorescence; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Lasers; Microdialysis; Rats | 2002 |
Ontogenic modifications in the effect of the GABAergic system on the hypothalamic excitatory amino acids: its relationship with GABAergic control of gonadotrophin secretion during sexual maturation in female rats.
Topics: Aging; Aminooxyacetic Acid; Animals; Aspartic Acid; Excitatory Amino Acids; Female; Follicle Stimulating Hormone; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropins; Hypothalamus; Luteinizing Hormone; Neurons; Rats; Sexual Maturation; Synaptic Transmission | 2002 |
The simultaneous biosynthesis and uptake of amino acids by Lactococcus lactis studied by (13)C-labeling experiments.
Topics: Alanine; Amino Acids; Aspartic Acid; Biomass; Cell Membrane; Computer Simulation; Culture Media; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Isotope Labeling; Lactococcus lactis; Models, Biological; Models, Chemical; Phenylalanine; Threonine | 2002 |
Dipeptide utilization by the periodontal pathogens Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens and Fusobacterium nucleatum.
Topics: Aspartic Acid; Culture Media; Dipeptides; Fusobacterium nucleatum; Glutamic Acid; Peptides; Polyglutamic Acid; Porphyromonas gingivalis; Prevotella; Prevotella intermedia | 2002 |
Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid; Aspartic Acid Endopeptidases; Cell Line; Cells, Cultured; Endopeptidases; Glutamic Acid; Humans; Peptide Fragments; Transfection | 2002 |
Long-term effects of light damage on the retina of albino and pigmented rats.
Topics: Animals; Apoptosis; Aspartic Acid; Chromatography, High Pressure Liquid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; In Situ Nick-End Labeling; Light; Longitudinal Studies; Male; Radiation Injuries, Experimental; Rats; Rats, Long-Evans; Rats, Wistar; Retina; Retinal Degeneration; Taurine; Vitreous Body | 2002 |
Effects of metabotropic glutamate receptor agonists and antagonists on D-aspartate release from mouse cerebral cortical and striatal slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; N-Methylaspartate; Receptors, Metabotropic Glutamate; Tritium | 2001 |
Tn5 transposase active site mutants.
Topics: Arginine; Aspartic Acid; Base Sequence; Binding Sites; Catalysis; Crystallography, X-Ray; DNA, Bacterial; Glutamic Acid; Lysine; Models, Molecular; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Mutation; Plasmids; Protein Conformation; Transposases; Tyrosine | 2002 |
Relationship between brain temperature, brain chemistry and oxygen delivery after severe human head injury: the effect of mild hypothermia.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Body Temperature; Brain; Brain Chemistry; Brain Injuries; Carbon Dioxide; Extracellular Space; Glucose; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Hypothermia, Induced; Intracranial Hypertension; Lactic Acid; Microdialysis; Middle Aged; Oxygen Consumption; Treatment Outcome | 2002 |
Time courses of aspartate and glutamate concentrations in the focus area during penicillin induced epileptiform activity in awake rats.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Electroencephalography; Glutamic Acid; Male; Microdialysis; Penicillins; Rats; Rats, Wistar; Seizures; Time Factors | 2002 |
Amino acid concentrations in the blood of the jugular vein and peripheral artery after traumatic brain injury: decreased release of glutamate into the jugular vein in the early phase.
Topics: Adolescent; Adult; Aged; Amino Acids; Arteries; Aspartic Acid; Brain Injuries; Cystine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Jugular Veins; Male; Middle Aged | 2002 |
Cooperation between independent hippocampal synapses is controlled by glutamate uptake.
Topics: Animals; Aspartic Acid; Biological Transport; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Patch-Clamp Techniques; Piperazines; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses | 2002 |
Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV.
Topics: Adenosine Deaminase; Alleles; Amino Acid Sequence; Animals; Arginine; Aspartic Acid; Blotting, Western; Crystallography, X-Ray; Dipeptidyl Peptidase 4; DNA, Complementary; Dose-Response Relationship, Drug; Epitopes; Glutamic Acid; Humans; Kidney; Kinetics; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Binding; Rabbits; Sequence Homology, Amino Acid; Surface Plasmon Resonance; Thermodynamics; Time Factors | 2002 |
Glutamic acid-65 is an essential residue for catalysis in Proteus mirabilis glutathione S-transferase B1-1.
Topics: Aspartic Acid; Catalysis; Circular Dichroism; Dinitrochlorobenzene; Glutamic Acid; Glutathione; Glutathione Transferase; Kinetics; Mutagenesis, Site-Directed; Oligonucleotides; Protein Denaturation; Protein Structure, Tertiary; Proteus mirabilis; Serine; Spectrometry, Fluorescence; Temperature; Time Factors | 2002 |
Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population-based cohort.
Topics: Alleles; Aspartic Acid; Blood Pressure; Carotid Stenosis; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Endothelium, Vascular; Female; Finland; Gene Frequency; Genetics, Population; Genotype; Glutamic Acid; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Polymorphism, Genetic; Risk | 2002 |
Molecular and regulatory properties of leucoplast pyruvate kinase from Brassica napus (rapeseed) suspension cells.
Topics: Adenosine Triphosphate; Allosteric Site; Amino Acid Sequence; Aspartic Acid; Brassica napus; Cations; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Glutamic Acid; Hydrogen-Ion Concentration; Immunoblotting; Inhibitory Concentration 50; Ketoglutaric Acids; Kinetics; Metals; Models, Biological; Molecular Sequence Data; NADP; Oxalates; Peptides; Phosphoenolpyruvate; Protein Structure, Tertiary; Pyruvate Kinase; Sequence Homology, Amino Acid | 2002 |
Proton MR spectroscopic study at 3 Tesla on glutamate/glutamine in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Brain; Creatine; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Reference Values; Tissue Distribution | 2002 |
Metabolic compartmentation in cortical synaptosomes: influence of glucose and preferential incorporation of endogenous glutamate into GABA.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Citric Acid Cycle; Drug Synergism; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Hypoglycemia; Magnetic Resonance Spectroscopy; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Synaptosomes | 2002 |
A comparison of some metabolic effects of N-methylaspartate stereoisomers, glutamate and depolarization: a multinuclear MRS study.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Dizocilpine Maleate; Electrophysiology; Energy Metabolism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Lactic Acid; Magnetic Resonance Spectroscopy; N-Methylaspartate; Osmolar Concentration; Phosphocreatine; Stereoisomerism | 2002 |
Application of NMR spectroscopy to monitoring MELAS treatment: a case report.
Topics: Adolescent; Aspartic Acid; Brain; Creatine; Female; Glutamic Acid; Humans; Inositol; Lactic Acid; Magnetic Resonance Spectroscopy; MELAS Syndrome; Muscle, Skeletal; Phosphocreatine; Phosphorus; Phosphorylation | 2002 |
Astrocytes from Na(+)-K(+)-Cl(-) cotransporter-null mice exhibit absence of swelling and decrease in EAA release.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Aspartic Acid; Astrocytes; Bumetanide; Cell Size; Cells, Cultured; Cerebral Cortex; Chlorides; Diuretics; Glutamic Acid; Mice; Mice, Knockout; Microscopy, Fluorescence; Potassium; Rats; Sodium; Sodium-Potassium-Chloride Symporters | 2002 |
Direct evidence that release-stimulating alpha7* nicotinic cholinergic receptors are localized on human and rat brain glutamatergic axon terminals.
Topics: Adolescent; Adult; alpha7 Nicotinic Acetylcholine Receptor; Animals; Aspartic Acid; Bacterial Toxins; Brain; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Cyanobacteria Toxins; Exocytosis; Female; Glutamic Acid; Humans; Male; Marine Toxins; Microcystins; Middle Aged; Nicotinic Agonists; Nicotinic Antagonists; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptosomes; Tropanes | 2002 |
Dizocilpine inhibits amphetamine-induced formation of nitric oxide and amphetamine-induced release of amino acids and acetylcholine in the rat brain.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Brain; Cerebral Cortex; Corpus Striatum; Dextroamphetamine; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamic Acid; Lipid Peroxidation; Male; Neuroprotective Agents; Nitric Oxide; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 2002 |
Dorsal horn synaptosomal content of aspartate, glutamate, glycine and GABA are differentially altered following chronic constriction injury to the rat sciatic nerve.
Topics: Age Factors; Animals; Aspartic Acid; Causalgia; Down-Regulation; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hyperalgesia; Male; Neural Inhibition; Pain Threshold; Peripheral Nervous System Diseases; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Synaptic Transmission; Synaptosomes; Up-Regulation | 2002 |
Expression of angiotensin II type 1 (AT(1)) receptor in the rostral ventrolateral medulla in rats.
Topics: Angiotensin II; Animals; Aspartic Acid; Cell Membrane; Endoplasmic Reticulum; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Male; Medulla Oblongata; Microdialysis; Microinjections; Microscopy, Immunoelectron; Neurons; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Species Specificity; Tyrosine 3-Monooxygenase | 2002 |
Crystallinity and solubility characteristics of hydroxyapatite adsorbed amino acid.
Topics: Adsorption; Amino Acids; Aspartic Acid; Crystallization; Durapatite; Glutamic Acid; Glycine; Materials Testing; Microscopy, Electron, Scanning; Models, Chemical; Serine; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2002 |
Age-dependent changes in 24-hour rhythms of thymic and circulating growth hormone and adrenocorticotropin in rats injected with Freund's adjuvant.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Aspartic Acid; Behavior, Animal; Chronobiology Disorders; Circadian Rhythm; Freund's Adjuvant; gamma-Aminobutyric Acid; Glutamic Acid; Growth Hormone; Immunologic Surveillance; Inflammation; Male; Pituitary-Adrenal System; Rats; Rats, Wistar; Taurine; Thymus Gland | 2001 |
Delayed anoxic depolarizations in hippocampal neurons of mice lacking the excitatory amino acid carrier 1.
Topics: Animals; Aspartic Acid; Biological Transport; Electric Conductivity; Electrophysiology; Excitatory Amino Acid Transporter 1; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hippocampus; Hypoxia, Brain; Male; Mice; Mice, Transgenic; Neurons; Patch-Clamp Techniques; Time Factors | 2002 |
Release of excitatory amino acids in the penumbra of a focal cortical necrosis.
Topics: Alanine; Animals; Aspartic Acid; Cerebral Cortex; Excitatory Amino Acids; Glutamic Acid; Glycine; Male; Microdialysis; Necrosis; Rats; Serine | 2002 |
Aspartate aminotransferase isotope exchange reactions: implications for glutamate/glutamine shuttle hypothesis.
Topics: Alkalies; Aspartate Aminotransferases; Aspartic Acid; Catalysis; Citric Acid Cycle; Glutamic Acid; Glutamine; Ketoglutaric Acids; Malate Dehydrogenase; Oxaloacetic Acid; Tritium | 2002 |
Role of the glutamic and aspartic residues in Na+-ATPase function in the ZrENA1 gene of Zygosaccharomyces rouxii.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Drug Resistance, Microbial; Fungal Proteins; Genes, Fungal; Glutamic Acid; Ion Transport; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Tertiary; Sequence Alignment; Sequence Homology, Nucleic Acid; Sodium Chloride; Sodium-Hydrogen Exchangers; Structure-Activity Relationship; Zygosaccharomyces | 2002 |
Release patterns of excitatory and inhibitory amino acids within the hypothalamic supraoptic nucleus in response to direct nitric oxide administration during forced swimming in rats.
Topics: Animals; Aspartic Acid; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamo-Hypophyseal System; Male; Microdialysis; Neural Inhibition; Neurons; Neurotransmitter Agents; Nitric Oxide; Rats; Rats, Wistar; Stress, Physiological; Supraoptic Nucleus; Swimming; Synapses; Synaptic Transmission; Taurine | 2002 |
Measurement of side-chain carboxyl pK(a) values of glutamate and aspartate residues in an unfolded protein by multinuclear NMR spectroscopy.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Drosophila; Drosophila Proteins; Fourier Analysis; Glutamic Acid; Insect Proteins; Kinetics; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Protein Folding; src Homology Domains | 2002 |
Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Fragile X Mental Retardation Protein; Fragile X Syndrome; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Homovanillic Acid; Hydroxyindoleacetic Acid; Intellectual Disability; Male; Mice; Mice, Knockout; Models, Animal; Nerve Tissue Proteins; RNA-Binding Proteins; Serotonin; Taurine; Thalamus | 2001 |
The kinetic mechanism of the glutamate-aspartate carrier in rat intestinal brush-border membrane vesicles: the role of potassium.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport, Active; Glutamic Acid; In Vitro Techniques; Intestinal Mucosa; Kinetics; Microvilli; Models, Biological; Potassium; Rats; Rats, Sprague-Dawley | 2002 |
gamma-glutamate and beta-hydroxyaspartate in proteins.
Topics: Aspartic Acid; Chromatography, High Pressure Liquid; Glutamic Acid; Proteins | 2002 |
An essential amino acid residue for catalytic activity of the dextranase of Streptococcus mutans.
Topics: Amino Acid Sequence; Amino Acids, Essential; Asparagine; Aspartic Acid; Binding Sites; Dextranase; Glucosyltransferases; Glutamic Acid; Humans; Molecular Biology; Mutagenesis, Site-Directed; Sequence Analysis, Protein; Streptococcus; Streptococcus mutans; Streptococcus sobrinus; Threonine; Valine | 2002 |
Possible glutamatergic/aspartatergic projections to the supramammillary nucleus and their origins in the rat studied by selective [(3)H]D-aspartate labelling and immunocytochemistry.
Topics: Animals; Aspartic Acid; Brain Stem; Cell Count; Diagonal Band of Broca; Glutamic Acid; Gold Colloid; Habenula; Immunohistochemistry; Male; Mammillary Bodies; Neural Pathways; Neurons; Preoptic Area; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Septum of Brain; Serotonin; Tissue Distribution; Tritium; Wheat Germ Agglutinins | 2002 |
Inhibitor of glutamate transport alters synaptic transmission at sensorimotor synapses in Aplysia.
Topics: Action Potentials; Animals; Aplysia; Aspartic Acid; Excitatory Postsynaptic Potentials; Glutamic Acid; Motor Neurons; Neural Inhibition; Neurons, Afferent; Synaptic Transmission | 2002 |
Involvement of nitric oxide, cyclic GMP and phosphodiesterase 5 in excitatory amino acid and GABA release in the nucleus accumbens evoked by activation of the hippocampal fimbria.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aspartic Acid; Catheterization; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Drug Administration Routes; Electric Stimulation; Electrodes, Implanted; Enzyme Inhibitors; Excitatory Amino Acids; Fornix, Brain; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nucleus Accumbens; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley | 2002 |
Analysis of two acidic P6 pocket residues in the pH dependency of peptide binding by I-E(k).
Topics: Animals; Aspartic Acid; Glutamic Acid; Histocompatibility Antigens Class II; HLA-D Antigens; Humans; Hydrogen-Ion Concentration; Mice; Mutation; Peptides; Protein Conformation | 2002 |
Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury.
Topics: Animals; Aspartic Acid; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Excitatory Amino Acids; Extracellular Space; Glucose; Glutamic Acid; Glycine; Hippocampus; Male; Microdialysis; Neurons; Rats; Rats, Sprague-Dawley; Sodium Channels; Up-Regulation | 2002 |
Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function.
Topics: Adult; Amino Acid Substitution; Aspartic Acid; Blood Flow Velocity; Blood Pressure; Brachial Artery; Diet; Endothelium, Vascular; Fatty Acids, Omega-3; Female; Genotype; Glutamic Acid; Humans; Lipids; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroglycerin; Polymorphism, Genetic; Risk Factors; Smoking; Vasodilation | 2002 |
Antagonists of protein kinase C inhibit rat retinal glutamate transport activity in situ.
Topics: Acetophenones; Alkaloids; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Benzophenanthridines; Benzopyrans; Biological Transport; Blotting, Western; Carbazoles; Enzyme Inhibitors; Glutamic Acid; Immunohistochemistry; In Vitro Techniques; Indoles; Isoenzymes; Phenanthridines; Protein Kinase C; Rats; Rats, Inbred Strains; Retina | 2002 |
Beta-amyloid enhances glial glutamate uptake activity and attenuates synaptic efficacy.
Topics: Amino Acid Transport System X-AG; Amyloid beta-Peptides; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biological Transport; Biotinylation; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Membrane Potentials; Membrane Proteins; Patch-Clamp Techniques; Peptide Fragments; Rats; Synapses; Synaptic Transmission | 2002 |
The structure of an allosamidin complex with the Coccidioides immitis chitinase defines a role for a second acid residue in substrate-assisted mechanism.
Topics: Acetylglucosamine; Aspartic Acid; Binding Sites; Catalysis; Catalytic Domain; Chitinases; Coccidioides; Crystallography, X-Ray; Glutamic Acid; Glycoside Hydrolases; Kinetics; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Protein Binding; Trisaccharides | 2002 |
Protein folding kinetics beyond the phi value: using multiple amino acid substitutions to investigate the structure of the SH3 domain folding transition state.
Topics: Amino Acids; Aspartic Acid; Dose-Response Relationship, Drug; Glutamic Acid; Guanidine; Hydrogen Bonding; Kinetics; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Folding; Serine; src Homology Domains; Thermodynamics | 2002 |
Effect of replacing the aspartic acid/glutamic acid residues of bullfrog sialic acid binding lectin with asparagine/glutamine and arginine on the inhibition of cell proliferation in murine leukemia P388 cells.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; Arginine; Asparagine; Aspartic Acid; Cell Division; Circular Dichroism; Cloning, Molecular; Escherichia coli; Glutamic Acid; HL-60 Cells; Humans; Lectins; Leukemia P388; Mice; Microscopy, Fluorescence; Mutagenesis, Site-Directed; N-Acetylneuraminic Acid; Rana catesbeiana; Ribonucleases | 2002 |
Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development and in adult rat tissues.
Topics: Animals; Aspartic Acid; Calcium; Carrier Proteins; Female; Gene Expression Regulation, Developmental; Glutamic Acid; Hematopoietic System; Humans; Liver; Membrane Transport Proteins; Mice; Mice, Inbred BALB C; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Muscle, Skeletal; Organ Specificity; Rats; Rats, Wistar | 2002 |
Feeding-induced decrease in extracellular glutamate level in the rat nucleus accumbens: dependence on glutamate uptake.
Topics: Analysis of Variance; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dopamine Antagonists; Eating; Extracellular Space; Feeding Behavior; Glutamic Acid; Male; Microdialysis; Neurotransmitter Uptake Inhibitors; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Time Factors | 2002 |
Ischemia-induced glutamate release in rat frontoparietal cortex after chronic alcohol and withdrawal.
Topics: Alcoholism; Animals; Aspartic Acid; Central Nervous System Depressants; Dialysis Solutions; Ethanol; Glutamic Acid; Ischemic Attack, Transient; Male; Microdialysis; Parietal Lobe; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2002 |
An essential role of N-terminal arginylation in cardiovascular development.
Topics: Alkylation; Aminoacyltransferases; Animals; Aorta; Arginine; Aspartic Acid; Blood Vessels; Cell Line; Cysteic Acid; Cysteine; Female; Glutamic Acid; Heart; Heart Defects, Congenital; Heart Septal Defects; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Oxidation-Reduction; Proteins; Pulmonary Artery; Recombinant Proteins; RGS Proteins; Sulfinic Acids; Transcription Factors; Transfection | 2002 |
Effects of bilobalide on amino acid release and electrophysiology of cortical slices.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Cyclopentanes; Diterpenes; Electrophysiology; Furans; Ginkgolides; Glutamic Acid; In Vitro Techniques; Magnesium; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; N-Methylaspartate; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Oximes; Potassium; Veratridine | 2002 |
Genetic evaluation of the common variant of the endothelial nitric oxide synthase (Glu(298)->
Topics: Aspartic Acid; Case-Control Studies; Endothelium, Vascular; Female; Genetic Variation; Glutamic Acid; Heterozygote; Homozygote; Humans; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Smoking; Thromboangiitis Obliterans | 2002 |
Glutamate transporters and retinal excitotoxicity.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Glutamic Acid; Nerve Degeneration; Neuroglia; Rats; Rats, Sprague-Dawley; Retina | 2002 |
Empirical relationships between protein structure and carboxyl pKa values in proteins.
Topics: Animals; Aspartic Acid; Glutamic Acid; Hydrogen Bonding; Isoelectric Point; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Proteins; Reproducibility of Results; Sequence Analysis, Protein; Solvents; Static Electricity | 2002 |
Dynamic determination and possible mechanism of amino acid transmitter release from rat spinal dorsal horn induced by the venom and a neurotoxin (BmK I) of scorpion Buthus martensi Karsch.
Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Neurotransmitter Agents; Nociceptors; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Scorpion Venoms | 2002 |
Lys 43 and Asp 46 in alpha-helix 3 of uteroglobin are essential for its phospholipase A2 inhibitory activity.
Topics: Aspartic Acid; Calcium; Chromatography, Thin Layer; Dimerization; DNA, Complementary; Dose-Response Relationship, Drug; Glutamic Acid; Lysine; Mutagenesis, Site-Directed; Mutation; Phospholipases A; Phospholipases A2; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Uteroglobin | 2002 |
Aluminum L-glutamate complex in rat brain cortex: in vivo prevention of aluminum deposit by magnesium D-aspartate.
Topics: Aluminum; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Cerebral Cortex; Chelating Agents; Glutamic Acid; Male; Rats; Rats, Wistar; Spectrophotometry, Atomic; Stereoisomerism | 2002 |
[2,4-13 C2 ]-beta-Hydroxybutyrate metabolism in human brain.
Topics: 3-Hydroxybutyric Acid; Acetyl Coenzyme A; Aspartic Acid; Blood-Brain Barrier; Brain; Carbon Isotopes; Glutamic Acid; Glutamine; Humans; Ketones; Kinetics; Magnetic Resonance Spectroscopy; Neurons; Oxidation-Reduction | 2002 |
Levels of amino acid neurotransmitters during neurogenesis and in histotypic cultures of mouse spinal cord.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Interneurons; Male; Mice; Microscopy, Electron; Neurotoxins; Neurotransmitter Agents; Organ Culture Techniques; Spinal Cord; Synapses; Taurine | 2002 |
Localization of putative glutamatergic/aspartatergic neurons projecting to the supraoptic nucleus area of the rat hypothalamus.
Topics: Afferent Pathways; Animals; Aspartic Acid; Autoradiography; Brain Stem; Diencephalon; Glutamic Acid; Immunohistochemistry; Male; Rats; Rats, Sprague-Dawley; Supraoptic Nucleus; Telencephalon | 2002 |
Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes.
Topics: Animals; Aspartic Acid; Excitatory Amino Acid Transporter 1; Female; Glutamic Acid; Glycerol; Humans; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Permeability; Sodium; Temperature; Urea; Water; Xenopus laevis | 2002 |
Long-time in-vivo metabolic monitoring following experimental brain contusion using proton magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Brain Injuries; Disease Models, Animal; Functional Laterality; Glutamic Acid; Hippocampus; Lactates; Magnetic Resonance Imaging; Male; Monitoring, Physiologic; Phosphocreatine; Rats; Rats, Sprague-Dawley; Reference Values; Taurine; Time Factors | 2002 |
Regional levels of glucose, amino acids, high energy phosphates, and cyclic nucleotides in the central nervous system during hypoglycemic stupor and behavioral recovery.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Amino Acids; Animals; Aspartic Acid; Behavior, Animal; Central Nervous System; Coma; Cyclic AMP; Cyclic GMP; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glycogen; Hypoglycemia; Insulin; Male; Mice; Phosphocreatine; Recovery of Function | 1976 |
Determination of the ionization state and catalytic function of Glu-133 in peptide deformylase by difference FTIR spectroscopy.
Topics: Absorption; Alanine; Amides; Amidohydrolases; Amino Acid Substitution; Aminopeptidases; Aspartic Acid; Buffers; Catalysis; Chlorides; Cobalt; Escherichia coli Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Metalloproteins; Mutagenesis, Site-Directed; Protons; Spectroscopy, Fourier Transform Infrared | 2002 |
The influence of amino acids on the biomineralization of hydroxyapatite in gelatin.
Topics: Amino Acids; Aspartic Acid; Calcium Phosphates; Durapatite; Gelatin; Gels; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Microscopy, Electron, Scanning; Serine; Thermodynamics; Tromethamine; X-Ray Diffraction | 2002 |
Compound heterozygosity for Hb Korle-Bu (beta(73); Asp-Asn) and Hb E (beta(26); Glu-Lys) with a 3.7-kb deletional alpha-thalassemia in Thai patients.
Topics: Adolescent; Adult; Aged; alpha-Thalassemia; Asparagine; Aspartic Acid; Base Sequence; Chromosome Segregation; Female; Gene Deletion; Glutamic Acid; Hemoglobin E; Hemoglobins, Abnormal; Heterozygote; Humans; Lysine; Male; Middle Aged; Pregnancy; Thailand | 2002 |
Electrostatic contributions to site specific DNA cleavage by EcoRV endonuclease.
Topics: Alanine; Aspartic Acid; Binding Sites; Catalysis; Cations, Divalent; Crystallography, X-Ray; Deoxyribonucleases, Type II Site-Specific; DNA, Bacterial; Glutamic Acid; Kinetics; Lysine; Manganese; Mutagenesis, Site-Directed; Static Electricity | 2002 |
Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy.
Topics: Adult; Anticonvulsants; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Epilepsy; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Occipital Lobe; Valproic Acid | 2002 |
Proton MRS in Kennedy disease: absolute metabolite and macromolecular concentrations.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Muscular Atrophy, Spinal; Pons | 2002 |
Crystallographic investigation of the role of aspartate 95 in the modulation of the redox potentials of Desulfovibrio vulgaris flavodoxin.
Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Binding Sites; Computer Simulation; Crystallography, X-Ray; Desulfovibrio vulgaris; Flavin Mononucleotide; Flavodoxin; Glutamic Acid; Hydrogen Bonding; Hydroquinones; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Conformation; Protein Structure, Secondary; Static Electricity; Thermodynamics | 2002 |
Characterization of iron-binding motifs in Candida albicans high-affinity iron permease CaFtr1p by site-directed mutagenesis.
Topics: Amino Acid Motifs; Amino Acid Sequence; Arginine; Aspartic Acid; Binding Sites; Candida albicans; Cell Division; Fungal Proteins; Glutamic Acid; Iron; Membrane Transport Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed | 2002 |
Ferrous ion binding to recombinant human H-chain ferritin. An isothermal titration calorimetry study.
Topics: Amino Acid Substitution; Apoferritins; Aspartic Acid; Binding Sites; Calorimetry; Ceruloplasmin; Ferrous Compounds; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Isoleucine; Oxidation-Reduction; Phenylalanine; Protein Folding; Recombinant Proteins; Thermodynamics | 2002 |
Glutamate-induced calcium increase in myotubes depends on up-regulation of a sodium-dependent transporter.
Topics: 2-Chloroadenosine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Calcium; Cell Differentiation; Cells, Cultured; Cycloheximide; Dicarboxylic Acids; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Protein Synthesis Inhibitors; Purines; Pyrrolidines; Symporters; Up-Regulation | 2002 |
Mapping the type I collagen-binding site on pigment epithelium-derived factor. Implications for its antiangiogenic activity.
Topics: Animals; Aspartic Acid; Binding Sites; Cattle; Cell Line; Collagen Type I; Cornea; Cricetinae; Eye Proteins; Fluorescein; Glutamic Acid; Heparin; Humans; Lysine; Models, Molecular; Nerve Growth Factors; Peptides; Polyelectrolytes; Polymers; Protein Binding; Protein Structure, Tertiary; Proteins; Radioligand Assay; Recombinant Proteins; Serpins; Vitreous Body | 2002 |
The Glu298Asp polymorphism in endothelial nitric oxide synthase gene is associated with coronary in-stent restenosis.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Coronary Restenosis; Endothelium, Vascular; Female; Genotype; Glutamic Acid; Humans; Logistic Models; Male; Middle Aged; Mutation, Missense; Nitric Oxide Synthase; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Stents | 2002 |
The involvement of sodium and calcium ions in the release of amino acid neurotransmitters from mouse cortical slices elicited by hyperforin.
Topics: Animals; Antidepressive Agents; Aspartic Acid; Bridged Bicyclo Compounds; Calcium; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred BALB C; Neurotransmitter Agents; Phloroglucinol; Potassium Channel Blockers; Potassium Channels; Sodium; Sodium Channel Blockers; Sodium Channels; Terpenes; Tetrodotoxin; Veratridine | 2002 |
Coupling sap flow velocity and amino acid concentrations as an alternative method to (15)N labeling for quantifying nitrogen remobilization by walnut trees.
Topics: Amino Acids; Arginine; Aspartic Acid; Biological Transport; Citrulline; gamma-Aminobutyric Acid; Glutamic Acid; Juglans; Light; Nitrogen; Nitrogen Isotopes; Plant Shoots; Rheology; Seasons; Time Factors | 2002 |
Anion channels influence ECC by modulating L-type Ca(2+) channel in ventricular myocytes.
Topics: Animals; Anions; Aspartic Acid; Calcium; Calcium Channels, L-Type; Chlorides; Cytosol; Female; Glutamic Acid; Heart Ventricles; Ion Channels; Myocardial Contraction; Myocardium; Niflumic Acid; Nitrobenzoates; Osmotic Pressure; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley | 2002 |
Differential effects of chronic haloperidol and clozapine administration on glutamatergic transmission in the fronto-parietal cortex in rats: microdialysis and electrophysiological studies.
Topics: Animals; Aspartic Acid; Clozapine; Electrophysiology; Frontal Lobe; Glutamic Acid; Haloperidol; Male; Microdialysis; Parietal Lobe; Rats; Rats, Wistar | 2002 |
Probing the role of glutamic acid 139 of Anabaena ferredoxin-NADP+ reductase in the interaction with substrates.
Topics: Anabaena; Aspartic Acid; Electron Transport; Ferredoxin-NADP Reductase; Flavodoxin; Glutamic Acid; Kinetics; Models, Molecular; NADP; Oxidation-Reduction; Point Mutation; Protein Conformation | 2002 |
In vivo temporal sequence of rat striatal glutamate, aspartate and dopamine efflux during apomorphine, nomifensine, NMDA and PDC in situ administration.
Topics: Animals; Apomorphine; Aspartic Acid; Dicarboxylic Acids; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Electrodes, Implanted; Electrophoresis, Capillary; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Neostriatum; Neurotransmitter Uptake Inhibitors; Nomifensine; Online Systems; Pyrrolidines; Rats; Rats, Sprague-Dawley | 2002 |
Effect of single and repeated methamphetamine treatment on neurotransmitter release in substantia nigra and neostriatum of the rat.
Topics: Amino Acids; Animals; Aspartic Acid; Biogenic Monoamines; Central Nervous System Stimulants; Dopamine; Drug Administration Routes; Drug Administration Schedule; Dynorphins; Endorphins; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Male; Methamphetamine; Microdialysis; Neostriatum; Neurotransmitter Agents; Potassium; Rats; Rats, Sprague-Dawley; Substantia Nigra; Synaptic Transmission | 2002 |
Neuronal and glial metabolite content of the epileptogenic human hippocampus.
Topics: Adult; Amino Acids; Aspartic Acid; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuroglia; Neurons | 2002 |
Cellular architecture of the nucleus reuniens thalami and its putative aspartatergic/glutamatergic projection to the hippocampus and medial septum in the rat.
Topics: Animals; Aspartic Acid; Calbindin 2; Calbindins; Glutamic Acid; Gold Colloid; Hippocampus; Immunohistochemistry; Male; Midline Thalamic Nuclei; Neural Pathways; Neuropeptides; Radioactive Tracers; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Septal Nuclei; Wheat Germ Agglutinins | 2002 |
Characterization of large peptide fragments derived from the N-terminal domain of the ribosomal protein L9: definition of the minimum folding motif and characterization of local electrostatic interactions.
Topics: Amino Acid Motifs; Amino Acid Sequence; Aspartic Acid; Circular Dichroism; Glutamic Acid; Hydrogen-Ion Concentration; Lysine; Models, Molecular; Molecular Sequence Data; Naphthalenesulfonates; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Ribosomal Proteins; Spectrometry, Fluorescence; Static Electricity | 2002 |
Adenosylcobalamin-dependent glutamate mutase: pre-steady-state kinetic methods for investigating reaction mechanism.
Topics: Acrylates; Aspartic Acid; Bacterial Proteins; Cobamides; Deoxyadenosines; Glutamic Acid; Intramolecular Transferases; Isomerism; Molecular Structure; Protein Binding; Spectrum Analysis; Vitamin B 12 | 2002 |
Metabolic pathways of carcinogenic chromium.
Topics: Aspartic Acid; Carcinogens, Environmental; Chromium; DNA Damage; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Microscopy, Ultraviolet; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2002 |
Outcome in prostate cancer: association with endothelial nitric oxide synthase Glu-Asp298 polymorphism at exon 7.
Topics: Aged; Aspartic Acid; Bone Neoplasms; Disease Progression; Exons; Genotype; Glutamic Acid; Humans; Logistic Models; Male; Middle Aged; Neoplasm Metastasis; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Prognosis; Prostatic Neoplasms; Treatment Outcome | 2002 |
Excitatory amino acid release in the spinal cord caused by plantar incision in the rat.
Topics: Animals; Asparagine; Aspartic Acid; Dermatologic Surgical Procedures; Glutamic Acid; Glutamine; Glycine; Male; Microdialysis; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Serine; Spinal Cord | 2002 |
Compartmentation of metabolism probed by [2-13C]alanine: improved 13C NMR sensitivity using a CryoProbe detects evidence of a glial metabolon.
Topics: Alanine; Animals; Aspartic Acid; Carbon Isotopes; Cell Compartmentation; Citric Acid Cycle; Electronics; Glutamic Acid; Glutamine; Guinea Pigs; In Vitro Techniques; Male; Nerve Tissue Proteins; Neuroglia; Nuclear Magnetic Resonance, Biomolecular; Pyruvate Carboxylase; Sensitivity and Specificity | 2003 |
L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus.
Topics: Animals; Arginase; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Argininosuccinic Acid; Aspartic Acid; Citrulline; Dinoprost; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Glutamic Acid; Glutamine; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Thiolester Hydrolases; Ubiquitin Thiolesterase | 2002 |
ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Blotting, Northern; Bone Marrow; Cell Nucleus; Cell Transformation, Neoplastic; Conserved Sequence; DNA-Binding Proteins; Glutamic Acid; HeLa Cells; Hematopoietic Stem Cells; Histone-Lysine N-Methyltransferase; Humans; Immunosorbent Techniques; Leukemia, Myeloid, Acute; Mice; Molecular Sequence Data; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Peptide Fragments; Proto-Oncogenes; Recombinant Fusion Proteins; Retroviridae; Sequence Homology; Serine; Transcription Factors; Transcriptional Elongation Factors; Transfection | 2003 |
Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.
Topics: Alkylation; Aspartic Acid; Cytochrome P-450 CYP2D6; Dextromethorphan; Glutamic Acid; Humans; Models, Molecular; Mutagenesis, Site-Directed; Substrate Specificity | 2003 |
The impact of Glu-->Ala and Glu-->Asp mutations on the crystallization properties of RhoGDI: the structure of RhoGDI at 1.3 A resolution.
Topics: Alanine; Aspartic Acid; Crystallization; Crystallography, X-Ray; Glutamic Acid; Guanine Nucleotide Dissociation Inhibitors; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; rho-Specific Guanine Nucleotide Dissociation Inhibitors | 2002 |
Participation of active-site carboxylates of Escherichia coli DNA polymerase I (Klenow fragment) in the formation of a prepolymerase ternary complex.
Topics: Amino Acid Substitution; Aspartic Acid; Binding Sites; Carboxylic Acids; Cations, Divalent; Dinucleoside Phosphates; DNA Polymerase I; DNA Primers; Electrophoretic Mobility Shift Assay; Enzyme Precursors; Enzyme Stability; Escherichia coli Proteins; Glutamic Acid; Macromolecular Substances; Mutagenesis, Site-Directed; Substrate Specificity; Templates, Genetic | 2002 |
Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis.
Topics: Amino Acid Sequence; Aspartic Acid; Catalysis; Conserved Sequence; Directed Molecular Evolution; Glutamic Acid; Histidine; Intramolecular Transferases; Lanosterol; Molecular Structure; Mutation; Structure-Activity Relationship; Yeasts | 2002 |
Solid-phase synthesis of diamine and polyamine amino acid derivatives as HIV-1 tat-TAR binding inhibitors.
Topics: Anti-HIV Agents; Aspartic Acid; Cell Fusion; Cell Line; Diamines; DNA, Viral; Gene Products, tat; Glutamic Acid; HeLa Cells; HIV Fusion Inhibitors; HIV Long Terminal Repeat; HIV-1; Humans; Polyamines; Structure-Activity Relationship; tat Gene Products, Human Immunodeficiency Virus; Transfection | 2003 |
beta-Agkistrodotoxin inhibition of Ca2+-dependent release of glutamate, aspartate, glycine and gamma-aminobutyric acid from cerebrocortical synaptosomes following its binding to synaptic membrane.
Topics: Animals; Aspartic Acid; Binding Sites; Calcium; Calcium Signaling; Cerebral Cortex; Crotalid Venoms; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Iodine Radioisotopes; Male; Models, Biological; Neurotoxins; Neurotransmitter Agents; Presynaptic Terminals; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Synaptic Membranes; Synaptic Transmission; Synaptosomes | 2002 |
Effect of ethanol on the palmitate-induced uncoupling of oxidative phosphorylation in liver mitochondria.
Topics: Animals; Antiporters; Aspartic Acid; Atractyloside; Ethanol; Fatty Acids; Glutamic Acid; Hydrogen-Ion Concentration; Magnesium Chloride; Mitochondria, Liver; Mitochondrial ADP, ATP Translocases; Oxidative Phosphorylation; Palmitates; Rats; Uncoupling Agents | 2002 |
Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis.
Topics: Alanine; Amino Acid Substitution; Animals; Antibodies, Monoclonal; Antigens, Ly; Aspartic Acid; Cell Line; Cell Membrane; Drosophila Proteins; Glutamic Acid; Humans; Ligands; Lipopolysaccharide Receptors; Lipopolysaccharides; Lymphocyte Antigen 96; Membrane Glycoproteins; Mice; Mutagenesis, Site-Directed; Paclitaxel; Receptors, Cell Surface; Toll-Like Receptor 4; Toll-Like Receptors; Transfection | 2003 |
Effect of different sample pretreatment methods on the concentrations of excitatory amino acids in cerebrospinal fluid determined by high-performance liquid chromatography.
Topics: Aspartic Acid; Chromatography, High Pressure Liquid; Glutamic Acid; Reproducibility of Results | 2003 |
The release of excitatory amino acids, dopamine, and potassium following transplantation of embryonic mesencephalic dopaminergic grafts to the rat striatum, and their effects on dopaminergic neuronal survival in vitro.
Topics: Animals; Aspartic Acid; Cell Death; Corpus Striatum; Dopamine; Excitatory Amino Acids; Extracellular Space; Female; Glutamic Acid; Graft Survival; Neurons; Parkinsonian Disorders; Potassium; Rats; Rats, Inbred Strains; Stem Cell Transplantation; Stem Cells; Substantia Nigra | 2002 |
A new method to estimate the relative bioavailability of individual amino acids in fish larvae using 13C-NMR spectroscopy.
Topics: Amino Acids; Animals; Aspartic Acid; Carbon; Chromatography, High Pressure Liquid; Glutamic Acid; Lysine; Magnetic Resonance Spectroscopy; Sea Bream | 2003 |
[Effect of tianma cuzhi keli (TMCZKL) on contents of transmitter amino acids of brain tissue in the mouse repetitious cerebral ischemia reperfusion].
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Drug Combinations; Drugs, Chinese Herbal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Mice; Neuroprotective Agents; Orchidaceae; Plants, Medicinal; Random Allocation; Reperfusion Injury; Rubiaceae | 2001 |
Scanning mutagenesis of the alpha repeats and of the transmembrane acidic residues of the human retinal cone Na/Ca-K exchanger.
Topics: Amino Acids, Acidic; Animals; Aspartic Acid; Cell Line; Cell Membrane; Dogs; Glutamic Acid; Glycine; Humans; Mutagenesis, Site-Directed; Photoreceptor Cells, Vertebrate; Potassium; Proline; Repetitive Sequences, Amino Acid; Retinal Cone Photoreceptor Cells; Sodium-Calcium Exchanger; Spodoptera; Transfection | 2003 |
Glutamate and aspartate do not exhibit the same changes in their extracellular concentrations in the rat striatum after N-methyl-D-aspartate local administration.
Topics: Animals; Aspartic Acid; Corpus Striatum; Extracellular Space; Glutamic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Charge-charge interactions are key determinants of the pK values of ionizable groups in ribonuclease Sa (pI=3.5) and a basic variant (pI=10.2).
Topics: Aspartic Acid; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Isoelectric Point; Isoenzymes; Lysine; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protein Denaturation; Ribonucleases; Tyrosine | 2003 |
Involvement of acetylated tubulin in the regulation of Na+,K+ -ATPase activity in cultured astrocytes.
Topics: Acetylation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Ionophores; Mice; Monensin; N-Methylaspartate; Sodium-Potassium-Exchanging ATPase; Tubulin | 2003 |
Vasopressin and oxytocin decrease excitatory amino acid release in adult rat supraoptic nucleus.
Topics: Age Factors; Animals; Anti-Bacterial Agents; Arginine Vasopressin; Aspartic Acid; Glutamic Acid; Hormone Antagonists; In Vitro Techniques; Male; Oxytocin; Peptides; Potassium; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Renal Agents; Supraoptic Nucleus; Vasopressins | 2003 |
[Simultaneous determination of 18 amino acids by reversed-phase high performance liquid chromatography with precolumn phenylisothiocyanate derivatization].
Topics: Amino Acids; Animals; Aspartic Acid; Cattle; Chromatography, High Pressure Liquid; Glutamic Acid; Isothiocyanates; Norleucine; Serine; Thiocyanates | 2002 |
Feasibility study using surface-enhanced Raman spectroscopy for the quantitative detection of excitatory amino acids.
Topics: Animals; Aspartic Acid; Colloids; Craniocerebral Trauma; Excitatory Amino Acids; Glutamic Acid; Humans; Microchemistry; Rats; Silver; Solutions; Spectrum Analysis, Raman; Water | 2003 |
Effect of partial substitution of dietary protein by a single gluconeogenic dispensable amino acid on hepatic glucose metabolism in rainbow trout (Oncorhynchus mykiss).
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Diet; Dietary Proteins; Dietary Supplements; Food Deprivation; Fructose-Bisphosphatase; Glucokinase; Gluconeogenesis; Glucose; Glucose-6-Phosphatase; Glutamic Acid; Liver; Mitochondria, Liver; Oncorhynchus mykiss; Phosphoenolpyruvate Carboxykinase (GTP); Pyruvate Kinase; RNA, Messenger | 2003 |
Changes in stability upon charge reversal and neutralization substitution in staphylococcal nuclease are dominated by favorable electrostatic effects.
Topics: Amino Acid Substitution; Aspartic Acid; Enzyme Stability; Glutamic Acid; Glutamine; Guanidine; Histidine; Hydrogen-Ion Concentration; Lysine; Micrococcal Nuclease; Models, Chemical; Normal Distribution; Poisson Distribution; Protein Denaturation; Protein Folding; Static Electricity; Surface Properties; Thermodynamics | 2003 |
Hippocampal region asymmetry assessed by 1H-MRS in rolandic epilepsy.
Topics: Adolescent; Aspartic Acid; Child; Choline; Creatine; Dominance, Cerebral; Electroencephalography; Energy Metabolism; Epilepsy, Rolandic; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Reference Values | 2003 |
[Analysis of amino acids in Trigonella foenumgraecum seeds].
Topics: Amino Acids; Aspartic Acid; Drugs, Chinese Herbal; Glutamic Acid; Glycine; Seeds; Trigonella; Tyrosine | 1998 |
Ionotropic glutamate receptors in cerebral microvascular endothelium are functionally linked to heme oxygenase.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Carbon Monoxide; Cells, Cultured; Cerebral Cortex; Cerebrovascular Circulation; Endothelium, Vascular; Excitatory Amino Acid Agonists; Glutamic Acid; Heme Oxygenase (Decyclizing); Ligands; Microcirculation; Receptors, Glutamate; Swine | 2003 |
Pharmacology of ischemia-induced glutamate efflux from rat cerebral cortex in vitro.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Brain Ischemia; Calcium Channel Blockers; Calcium Signaling; Cerebral Cortex; Chelating Agents; Chloride Channels; Female; Glutamic Acid; Ion Channels; Lanthanum; Magnesium; Neurons; Rats; Rats, Wistar; Sodium Channel Blockers | 2003 |
Modulation of glutamatergic transmission by bergmann glial cells in rat cerebellum in situ.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Cell Communication; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Neuroglia; Patch-Clamp Techniques; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Sodium; Synaptic Transmission | 2003 |
Investigations of Sso7d catalytic residues by NMR titration shifts and electrostatic calculations.
Topics: Archaeal Proteins; Aspartic Acid; Catalytic Domain; Dinucleoside Phosphates; DNA-Binding Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Models, Chemical; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Photochemistry; Recombinant Proteins; Ribonuclease T1; Ribonuclease, Pancreatic; Static Electricity; Sulfolobus; Thermodynamics; Titrimetry | 2003 |
Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Circular Dichroism; Crystallography, X-Ray; DNA; DNA-Formamidopyrimidine Glycosylase; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Glutamic Acid; Glutamine; Hot Temperature; Humans; Hydrolysis; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Glycosyl Hydrolases; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Substrate Specificity | 2003 |
[Effect of 4-aminopyridine on taurine-regulated release of amino acid from rat cortical synaptosomes].
Topics: 4-Aminopyridine; Animals; Aspartic Acid; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Synaptosomes; Taurine | 2001 |
Oxidative neuronal death caused by glutamate uptake inhibition in cultured hippocampal neurons.
Topics: Acetylcysteine; Amino Acid Transport System X-AG; Animals; Antioxidants; Aspartic Acid; Cell Death; Cells, Cultured; Dicarboxylic Acids; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glutamic Acid; Glutathione; Hippocampus; Neurons; Neurotransmitter Uptake Inhibitors; Oxidative Stress; Pyrrolidines; Rats; Rats, Wistar; Reactive Oxygen Species | 2003 |
Functional characterization of Glu298Asp mutant human endothelial nitric oxide synthase purified from a yeast expression system.
Topics: Aspartic Acid; Calmodulin; Coenzymes; Dimerization; Endothelium; Gene Expression; Glutamic Acid; Humans; Hydrogen Peroxide; Kinetics; Mutation, Missense; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pichia; Polymorphism, Genetic; Recombinant Proteins | 2003 |
Differential responses of an invariant region in the ectodomain of three glycoprotein hormone receptors to mutagenesis and assay conditions.
Topics: Adenylyl Cyclases; Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid; Colforsin; COS Cells; Cyclic AMP; Glutamic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Structure, Tertiary; Radioimmunoassay; Rats; Receptors, FSH; Receptors, LH; Receptors, Thyrotropin; Transfection | 2002 |
Pyruvate carboxylase is an essential protein in the assembly of yeast peroxisomal oligomeric alcohol oxidase.
Topics: Aspartic Acid; Blotting, Western; Cytosol; Glutamic Acid; Histidine; Immunohistochemistry; Microscopy, Electron; Mutation; Peroxisomes; Pichia; Plasmids; Protein Binding; Pyruvate Carboxylase; Spectrometry, Fluorescence; Time Factors | 2003 |
Slow binding of retinal to rhodopsin mutants G90D and T94D.
Topics: Alanine; Amino Acid Sequence; Animals; Aspartic Acid; Glutamic Acid; Glutamine; Glycine; Humans; Molecular Sequence Data; Mutagenesis, Insertional; Night Blindness; Protein Binding; Protein Denaturation; Retinaldehyde; Rhodopsin; Schiff Bases; Spectrophotometry, Ultraviolet; Threonine | 2003 |
Engineering a catalytic metal binding site into a calcium-independent phosphatidylinositol-specific phospholipase C leads to enhanced stereoselectivity.
Topics: Animals; Arginine; Asparagine; Aspartic Acid; Bacillus; Bacterial Proteins; Binding Sites; Calcium; Catalytic Domain; Cattle; Glutamic Acid; Glutamine; Metals, Alkaline Earth; Mutagenesis, Site-Directed; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Stereoisomerism; Streptomyces antibioticus; Substrate Specificity; Type C Phospholipases | 2003 |
Biphasic role of dopamine on female sexual behaviour via D2 receptors in the mediobasal hypothalamus.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Citrulline; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Estradiol; Extracellular Space; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Goats; Hypothalamus, Middle; Luteinizing Hormone; Microdialysis; Norepinephrine; Ovariectomy; Pimozide; Prolactin; Quinpirole; Receptors, Dopamine D2; Serotonin; Sexual Behavior, Animal; Spiperone; Taurine; Time Factors | 2003 |
The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Binding, Competitive; Biological Transport; Cells, Cultured; Cerebral Cortex; Cysteine; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutathione; Kainic Acid; Mice; Neurons; Sodium; Symporters | 2003 |
A pharmacological analysis of the contractile effects of glutamate on rat and human isolated gut smooth muscle strips.
Topics: Aged; Animals; Aspartic Acid; Cycloleucine; Evoked Potentials, Motor; Female; Gastric Fundus; Glutamic Acid; Humans; In Vitro Techniques; Intestine, Large; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Proline; Quisqualic Acid; Rats; Receptors, Glutamate; Rectum; Stomach | 2002 |
Synthesis and photoreactivity of caged blockers for glutamate transporters.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Cell Line; Coumarins; Dogs; Drug Stability; Glutamic Acid; Photolysis; Spectrophotometry, Ultraviolet | 2003 |
The urea cycle in the liver of arthritic rats.
Topics: Ammonia; Animals; Arthritis, Experimental; Aspartic Acid; Citrulline; Dose-Response Relationship, Drug; Glucose; Glutamic Acid; Kidney; Lactic Acid; Liver; Male; Models, Biological; Oxygen; Perfusion; Pyruvic Acid; Rats; Rats, Wistar; Time Factors; Urea | 2003 |
Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells.
Topics: Amino Acid Transport System X-AG; Ammonium Chloride; Analysis of Variance; Animals; Aspartic Acid; Carbon Isotopes; Cell Death; Cells, Cultured; Cerebellum; Excitatory Amino Acid Transporter 3; Glucose; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; L-Lactate Dehydrogenase; Magnetic Resonance Spectroscopy; Neurons; Rats; Rats, Sprague-Dawley; Sodium; Symporters | 2003 |
Co-variation of plasma sodium, taurine and other amino acid levels in critical illness.
Topics: Aspartic Acid; Critical Illness; Glutamic Acid; Humans; Phosphatidylethanolamines; Sodium; Taurine | 2003 |
Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence.
Topics: Aged; Aged, 80 and over; Amyloid beta-Peptides; Aspartic Acid; Binding Sites; Brain Chemistry; Cerebral Cortex; Copper; Female; Glutamic Acid; Humans; Iron; Metals, Heavy; Methionine; Microscopy; Oxidation-Reduction; Plaque, Amyloid; Protein Structure, Secondary; Spectrum Analysis, Raman; Tyrosine; Zinc | 2003 |
Proton transfer reactions in the F86D and F86E mutants of pharaonis phoborhodopsin (sensory rhodopsin II).
Topics: Amino Acid Substitution; Archaeal Proteins; Aspartic Acid; Carotenoids; Electrochemistry; Electron Transport; Freezing; Glutamic Acid; Halorhodopsins; Natronobacterium; Phenylalanine; Photochemistry; Proton Pumps; Sensory Rhodopsins; Spectroscopy, Fourier Transform Infrared | 2003 |
NMR determination of pKa values for Asp, Glu, His, and Lys mutants at each variable contiguous enzyme-inhibitor contact position of the turkey ovomucoid third domain.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid; Binding Sites; Genetic Variation; Glutamic Acid; Glycine; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Lysine; Models, Chemical; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Ovomucin; Protein Conformation; Protein Structure, Tertiary; Serine Proteinase Inhibitors; Thermodynamics; Threonine; Titrimetry; Turkeys | 2003 |
Modeling zinc in biomolecules with the self consistent charge-density functional tight binding (SCC-DFTB) method: applications to structural and energetic analysis.
Topics: Alcohol Dehydrogenase; Algorithms; Aminopeptidases; Aspartic Acid; Bacterial Proteins; Binding Sites; Carbonic Anhydrases; Cysteine; Glutamic Acid; Histidine; Liver; Models, Molecular; Molecular Conformation; Protein Binding; Protein Conformation; Water; Zinc | 2003 |
Dispensability of glutamic acid 48 and aspartic acid 134 for Mn2+-dependent activity of Escherichia coli ribonuclease HI.
Topics: Aspartic Acid; Base Sequence; Calorimetry; Circular Dichroism; DNA Primers; Escherichia coli; Genes, Bacterial; Glutamic Acid; Hydrogen-Ion Concentration; Manganese; Mutagenesis; Mutagenesis, Site-Directed; Ribonuclease H; Spectrophotometry, Ultraviolet; Thermodynamics | 2003 |
Adenosine-induced modulation of excitatory amino acid transport across isolated brain arterioles.
Topics: Adenosine; Animals; Arterioles; Aspartic Acid; Biological Transport; Blood-Brain Barrier; Capillary Permeability; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Glutamic Acid; In Vitro Techniques; Nitric Oxide Donors; Nitroprusside; Poly A; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Vasodilator Agents | 2003 |
Acid-neutralizing activity during amino acid fermentation by Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum.
Topics: Acid-Base Equilibrium; Acids; Amino Acids; Ammonia; Anaerobiosis; Aspartic Acid; beta-Alanine; Carboxylic Acids; Fermentation; Fusobacterium nucleatum; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Porphyromonas gingivalis; Prevotella intermedia | 2003 |
Neuronal glutamate uptake Contributes to GABA synthesis and inhibitory synaptic strength.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Excitatory Postsynaptic Potentials; Feedback, Physiological; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Neural Inhibition; Neurons; Osmolar Concentration; Patch-Clamp Techniques; Presynaptic Terminals; Pyramidal Cells; Rats; Synapses; Synaptic Transmission | 2003 |
Glutamate agonists release excitatory aminoacids from rat astrocytes.
Topics: Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Excitatory Amino Acid Agonists; Glutamic Acid; Magnetic Resonance Spectroscopy; Rats; Rats, Sprague-Dawley | 2003 |
Redox potential of quinones in photosynthetic reaction centers from Rhodobacter sphaeroides: dependence on protonation of Glu-L212 and Asp-L213.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Deuterium Oxide; Electron Transport; Glutamic Acid; Glutamine; Light; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Photosynthetic Reaction Center Complex Proteins; Protein Conformation; Protons; Quinones; Rhodobacter sphaeroides; Spectroscopy, Fourier Transform Infrared | 2003 |
Increased lysine synthesis coupled with a knockout of its catabolism synergistically boosts lysine content and also transregulates the metabolism of other amino acids in Arabidopsis seeds.
Topics: Amino Acids; Arabidopsis; Asparagine; Aspartic Acid; Bacteria; Bacterial Proteins; Gene Expression Regulation, Plant; Germination; Glutamic Acid; Glutamine; Hydro-Lyases; Lysine; Methionine; Mutation; Plants, Genetically Modified; Pterocarpans; Seeds; Signal Transduction; Threonine | 2003 |
Investigation on acetylcholine, aspartate, glutamate and GABA extracellular levels from ventral hippocampus during repeated exploratory activity in the rat.
Topics: Acetylcholine; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Excitatory Amino Acid Antagonists; Exploratory Behavior; Extracellular Space; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Habituation, Psychophysiologic; Hippocampus; Male; Microdialysis; Motor Activity; Rats; Rats, Wistar; Tetrodotoxin; Time Factors | 2003 |
A proton magnetic resonance spectroscopy study of metabolites in the occipital lobes in epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Carnosine; Epilepsies, Partial; Epilepsy, Generalized; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Image Enhancement; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neural Inhibition; Occipital Lobe; Synaptic Transmission | 2003 |
Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex.
Topics: Acute Disease; Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Prefrontal Cortex; Receptors, Glutamate | 2003 |
Endothelial nitric oxide synthase gene polymorphisms and renal survival.
Topics: Amino Acid Substitution; Aspartic Acid; Genetic Predisposition to Disease; Glutamic Acid; Humans; Kidney Failure, Chronic; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Genetic | 2003 |
1H MR spectroscopy of mesial temporal lobe epilepsies treated with Gamma knife.
Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Epilepsy, Temporal Lobe; Female; Follow-Up Studies; Glutamic Acid; Glutamine; Humans; Lipid Metabolism; Lipids; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Postoperative Complications; Radiation Injuries; Radiation Tolerance; Radiosurgery; Seizures; Time Factors; Treatment Failure | 2003 |
Endothelial nitric oxide synthase polymorphism in preeclampsia.
Topics: Adult; Aspartic Acid; Female; Finland; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Humans; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Pre-Eclampsia; Pregnancy; Retrospective Studies | 2003 |
Bidirectional exchange of amino compounds between phloem and xylem during long-distance transport in Norway spruce trees (Picea abies [L.] Karst).
Topics: Aspartic Acid; Biological Transport; Carbon Radioisotopes; Glutamic Acid; Nitrogen Isotopes; Picea; Plant Bark; Plant Leaves; Plant Stems; Plant Structures | 2003 |
Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus.
Topics: Amino Acid Sequence; Aspartic Acid; Cell Line; DNA, Complementary; Dose-Response Relationship, Drug; Epitopes; Genes, Reporter; Glucagon; Glutamic Acid; Humans; Inhibitory Concentration 50; Models, Biological; Molecular Sequence Data; Point Mutation; Protein Binding; Protein Structure, Tertiary; Receptors, Glucagon; Sequence Homology, Amino Acid | 2003 |
Role of the eNOS Glu298Asp variant on the GNB3825T allele dependent determination of alpha-adrenergic coronary constriction.
Topics: Adrenergic alpha-Agonists; Amino Acid Substitution; Aspartic Acid; Azepines; Blood Pressure; Coronary Circulation; Coronary Disease; Coronary Vessels; Genetic Variation; Genotype; Glutamic Acid; Heart Rate; Heterotrimeric GTP-Binding Proteins; Humans; Methoxamine; Mutation, Missense; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Receptors, Adrenergic, alpha; Vascular Resistance; Vasoconstriction | 2003 |
Identification of the L-aspartate transporter in Bacillus subtilis.
Topics: Amino Acid Transport Systems, Acidic; Amino Acids; Asparagine; Aspartic Acid; Bacillus subtilis; Bacterial Proteins; Carrier Proteins; Cell Division; Cloning, Molecular; Glutamic Acid; Mutation; Phylogeny; Recombinant Fusion Proteins; Substrate Specificity | 2003 |
Functional hemichannels in astrocytes: a novel mechanism of glutamate release.
Topics: Adenosine Triphosphate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Biological Transport; Calcium; Carbenoxolone; Cations, Divalent; Cells, Cultured; Chelating Agents; Connexin 43; Flufenamic Acid; Fluorescent Dyes; Gap Junctions; Glutamic Acid; Glycyrrhetinic Acid; Heptanol; Immunohistochemistry; Lanthanum; Octanols; Rats | 2003 |
Reductive half-reaction of nitroalkane oxidase: effect of mutation of the active site aspartate to glutamate.
Topics: Amino Acid Substitution; Aspartic Acid; Catalytic Domain; Dioxygenases; Fusarium; Glutamic Acid; Kinetics; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxygenases; Thermodynamics | 2003 |
Pore structure influences gating properties of the T-type Ca2+ channel alpha1G.
Topics: Aspartic Acid; Calcium Channels, T-Type; Electrophysiology; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Ion Channel Gating; Kidney; Kinetics; Models, Theoretical; Point Mutation; Transfection | 2003 |
Proton transport by proteorhodopsin requires that the retinal Schiff base counterion Asp-97 be anionic.
Topics: Aspartic Acid; Biological Transport; Escherichia coli; Glutamic Acid; Hydrogen-Ion Concentration; Ions; Kinetics; Mutation; Protons; Rhodopsin; Rhodopsins, Microbial; Schiff Bases; Time Factors | 2003 |
Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study.
Topics: Analysis of Variance; Animals; Asparagine; Aspartic Acid; Brain Ischemia; Cerebral Hemorrhage; Chromatography, High Pressure Liquid; Disease Models, Animal; Extracellular Space; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Microdialysis; Prospective Studies; Rabbits; Single-Blind Method; Stroke; Taurine; Time Factors | 2003 |
Anticonvulsant dicarboxyphenylglycines differentially modulate excitatory amino acid release in the rat cerebral cortex.
Topics: Animals; Anticonvulsants; Aspartic Acid; Benzoates; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acids; Glutamic Acid; Glycine; In Vitro Techniques; Male; Potassium Chloride; Protein Isoforms; Rats; Rats, Sprague-Dawley; Tritium | 2003 |
[Comparison of amino acid contents in Panax notoginseng from different habitats].
Topics: Arginine; Aspartic Acid; Ecosystem; Glutamic Acid; Panax; Plant Roots; Plants, Medicinal | 2003 |
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.
Topics: Aldehydes; Allosteric Site; Animals; Aspartic Acid; Binding Sites; Caspases; Catalytic Domain; Chymotrypsin; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Library; Glutamic Acid; Humans; Ketones; Kinetics; Multienzyme Complexes; Mutation; Peptide Hydrolases; Peptides; Proteasome Endopeptidase Complex; Protein Binding; Rabbits; Saccharomyces cerevisiae; Substrate Specificity; Time Factors; Trypsin | 2003 |
Glutamic acid residues as metal ligands in the active site of Escherichia coli alkaline phosphatase.
Topics: Alkaline Phosphatase; Amino Acid Substitution; Aspartic Acid; Binding Sites; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Ligands; Magnesium; Metals; Mutagenesis, Site-Directed; Phosphorylation; Structure-Activity Relationship; Zinc | 2003 |
An aversive diet as thiamine-free food blocks food-induced release of excitatory amino acids in the accumbens.
Topics: Adipose Tissue; Animals; Aspartic Acid; Body Temperature; Chromatography, High Pressure Liquid; Diet; Eating; Glutamic Acid; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Thermogenesis; Thiamine | 2003 |
Synaptic activation of presynaptic glutamate transporter currents in nerve terminals.
Topics: Amino Acid Transport System X-AG; Amino Acid Transport Systems; Animals; Aspartic Acid; Auditory Pathways; Brain Stem; Calcium Channel Blockers; Carrier Proteins; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 5; Exocytosis; Glutamic Acid; Goldfish; In Vitro Techniques; Patch-Clamp Techniques; Photoreceptor Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Retina; Synaptic Transmission | 2003 |
Glutamate-dependent glutamine, aspartate and serine release from rat cortical glial cell cultures.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anti-Inflammatory Agents; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Dexamethasone; Dicarboxylic Acids; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Glutamine; Neuroglia; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Serine; Time Factors | 2003 |
The activation of 5-HT(3) receptors evokes GABA release in the spinal cord.
Topics: Animals; Aspartic Acid; Biguanides; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Receptor Agonists; Spinal Cord; Time Factors | 2003 |
Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Caprylates; Carbon Isotopes; Energy Metabolism; Glucose; Glutamic Acid; Glutamine; Ketones; Liver; Magnetic Resonance Spectroscopy; Male; Models, Biological; Rats; Rats, Sprague-Dawley | 2003 |
Recombinant expression of the Ca(2+)-sensitive aspartate/glutamate carrier increases mitochondrial ATP production in agonist-stimulated Chinese hamster ovary cells.
Topics: Adenosine Triphosphate; Aequorin; Animals; Aspartic Acid; Binding Sites; Blotting, Western; Calcium; Calcium-Binding Proteins; Cell Membrane; CHO Cells; Cricetinae; Cytosol; Glutamic Acid; Humans; Luciferases; Luminescent Measurements; Membrane Transport Proteins; Microscopy, Fluorescence; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Molecular Sequence Data; Organic Anion Transporters; Oxygen; Plasmids; Protein Structure, Tertiary; Recombinant Proteins; Spectrometry, Fluorescence; Transfection | 2003 |
Genetic and environmental contributions to severe preeclampsia: lack of association with the endothelial nitric oxide synthase Glu298Asp variant in a developing country.
Topics: Adult; Aspartic Acid; Bangladesh; Birth Weight; Developing Countries; Environment; Female; Gene Frequency; Genetic Variation; Glutamic Acid; Homozygote; Humans; Infant, Newborn; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pre-Eclampsia; Pregnancy | 2003 |
Surface salt bridges modulate DNA wrapping by the type II DNA-binding protein TF1.
Topics: Alanine; Anions; Aspartic Acid; Bacillus subtilis; Bacteriophages; Cations; Cross-Linking Reagents; Dimerization; DNA; DNA-Binding Proteins; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Glutamic Acid; Glutaral; Ions; Kinetics; Lysine; Models, Molecular; Mutation; Pentoxyl; Plasmids; Protein Binding; Salts; Thermotoga maritima; Thymine; Viral Proteins | 2003 |
Correlating retinal function and amino acid immunocytochemistry following post-mortem ischemia.
Topics: Animals; Aspartic Acid; Electroretinography; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Immunohistochemistry; Ischemia; Rats; Rats, Sprague-Dawley; Retinal Vessels; Time Factors; Vision, Ocular | 2003 |
Sequence context strongly modulates association of polar residues in transmembrane helices.
Topics: Amino Acid Sequence; Amino Acids, Acidic; Amino Acids, Basic; Asparagine; Aspartic Acid; Capsid; Capsid Proteins; Glutamic Acid; Glutamine; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Membrane Proteins; Protein Structure, Tertiary; Recombinant Fusion Proteins | 2003 |
Lipoprotein lipase activity and common gene variants in severely hypertriglyceridemic patients with and without diabetes.
Topics: Adult; Apolipoproteins; Asparagine; Aspartic Acid; Diabetes Complications; Diabetes Mellitus; Female; Genetic Variation; Glutamic Acid; Glycine; Humans; Hyperlipoproteinemia Type IV; Lipoprotein Lipase; Male; Middle Aged; Phenotype; Serine; Severity of Illness Index | 2003 |
The role of glial glutamate transporters in maintaining the independent operation of juvenile mouse cerebellar parallel fibre synapses.
Topics: Action Potentials; Age Factors; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Excitatory Amino Acid Transporter 2; Excitatory Postsynaptic Potentials; Glutamic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers; Neuroglia; Purkinje Cells; Synapses; Temperature | 2003 |
Role of carboxylate residues adjacent to the conserved core Walker B motifs in the catalytic cycle of multidrug resistance protein 1 (ABCC1).
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Motifs; Amino Acid Sequence; Animals; Aspartic Acid; Biological Transport; Carboxylic Acids; Catalysis; Cell Line; Cell Membrane; DNA, Complementary; Drug Resistance, Multiple; Electrophoresis, Polyacrylamide Gel; Glutamic Acid; Humans; Hydrolysis; Insecta; Leukotriene C4; Light; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutation; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Time Factors; Vanadates | 2003 |
Kinetic differences between the isoforms of glutamate decarboxylase: implications for the regulation of GABA synthesis.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; Apoenzymes; Aspartic Acid; Cell Line; Enzyme Activation; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Holoenzymes; Isoenzymes; Kinetics; Spodoptera | 2003 |
Effects of chronic lithium and sodium valproate on concentrations of brain amino acids.
Topics: Alanine; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Lithium; Magnetic Resonance Imaging; Male; Rats; Rats, Sprague-Dawley; Taurine; Valproic Acid | 2003 |
FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10.
Topics: Amino Acid Substitution; Aspartic Acid; Blotting, Southern; Chromosomes, Human, Pair 10; Genes, Dominant; Genotype; Glutamic Acid; Haplotypes; Humans; Microsatellite Repeats; Microtubule-Associated Proteins; Mutation, Missense; Phenotype; Protein Serine-Threonine Kinases; Thrombocytopenia | 2003 |
Expression and regulation of L-cystine transporter, system xc-, in the newly developed rat retinal Müller cell line (TR-MUL).
Topics: Animals; Animals, Genetically Modified; Antigens, Viral, Tumor; Aspartic Acid; Biomarkers; Carrier Proteins; Cell Line, Transformed; Cystine; Fusion Regulatory Protein 1, Heavy Chain; Glutamic Acid; Glutathione; Male; Maleates; Models, Biological; Neuroglia; Oxidative Stress; Rats; Rats, Wistar; Retina; Retinal Diseases; Up-Regulation | 2003 |
Molecular motions of the outer ring of charge of the sodium channel: do they couple to slow inactivation?
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Cysteine; Electrophysiology; Glutamic Acid; Ion Channel Gating; Molecular Conformation; Muscle, Skeletal; Mutation; Oocytes; Phenanthrolines; Rats; Sodium Channels; Xenopus laevis | 2003 |
Using X-ray crystallography of the Asp55Asn mutant of the phosphatidylcholine-preferring phospholipase C from Bacillus cereus to support the mechanistic role of Asp55 as the general base.
Topics: Amino Acid Substitution; Aspartic Acid; Bacillus cereus; Catalysis; Crystallography, X-Ray; Glutamic Acid; Hydrogen-Ion Concentration; Ligands; Mutagenesis, Site-Directed; Phosphatidylcholines; Point Mutation; Protein Conformation; Substrate Specificity; Type C Phospholipases; Zinc | 2003 |
The effect of 6-hydroxydopamine lesions on the release of amino acids in the direct and indirect pathways of the basal ganglia: a dual microdialysis probe analysis.
Topics: Adrenergic Agents; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Basal Ganglia; Chromatography, High Pressure Liquid; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Microdialysis; Models, Animal; Oxidopamine; Parkinson Disease; Potassium; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase | 2003 |
A receptor for presynaptic glutamatergic autoinhibition is a glutamate transporter.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astacoidea; Chlorine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Ion Channels; Muscle, Skeletal; Neural Inhibition; Neuromuscular Junction; Patch-Clamp Techniques; Receptors, Glutamate; Receptors, Presynaptic; Sodium; Synaptic Transmission | 2003 |
Excitatory amino acids and multiple sclerosis: evidence from cerebrospinal fluid.
Topics: Adult; Aspartic Acid; Brain; Chromatography, High Pressure Liquid; Disability Evaluation; Gadolinium DTPA; Glutamic Acid; Humans; Image Enhancement; Magnetic Resonance Imaging; Male; Multiple Sclerosis; Spinal Cord | 2003 |
Dietary L-aspartate and L-glutamate inhibit fatty streak initiation in cholesterol-fed rabbit.
Topics: Animals; Arteriosclerosis; Aspartic Acid; Cholesterol; Cholesterol, Dietary; Diet, Atherogenic; Disease Models, Animal; Foam Cells; Glutamic Acid; Lipid Peroxidation; Lipoproteins, LDL; Male; Oxidation-Reduction; Rabbits; Random Allocation; Thiobarbituric Acid Reactive Substances | 2003 |
Synaptic vesicle transport and synaptic membrane transporter sites in excitatory amino acid nerve terminals in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Binding Sites; Biological Transport; Cerebral Cortex; Down-Regulation; Excitatory Amino Acids; Female; Glutamic Acid; Humans; Male; Middle Aged; Presynaptic Terminals; Radioligand Assay; Synaptic Membranes; Synaptic Vesicles; Tritium | 2003 |
Probing pH-dependent functional elements in proteins: modification of carboxylic acid pairs in Trichoderma reesei cellobiohydrolase Cel6A.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Binding Sites; Catalysis; Cellulase; Cellulose; Cellulose 1,4-beta-Cellobiosidase; Circular Dichroism; Enzyme Stability; Glutamic Acid; Hydrogen-Ion Concentration; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Denaturation; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Spectrometry, Fluorescence; Tetroses; Trichoderma | 2003 |
Specific isotopic labeling and photooxidation-linked structural changes in the manganese-stabilizing subunit of photosystem II.
Topics: Asparagine; Aspartic Acid; Escherichia coli; Gas Chromatography-Mass Spectrometry; Gene Expression; Glutamic Acid; Glutamine; Isotope Labeling; Manganese; Oxidation-Reduction; Photochemistry; Photosynthesis; Photosystem II Protein Complex; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared; Water | 2003 |
Requirement of a Tha4-conserved transmembrane glutamate in thylakoid Tat translocase assembly revealed by biochemical complementation.
Topics: Alanine; Aspartic Acid; Cross-Linking Reagents; DNA, Complementary; Escherichia coli; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Membrane Proteins; Models, Genetic; Pisum sativum; Plant Proteins; Point Mutation; Protein Structure, Tertiary; Protein Transport; Thylakoids | 2003 |
Temperature dependence of rat liver mitochondrial respiration with uncoupling of oxidative phosphorylation by fatty acids. Influence of inorganic phosphate.
Topics: 2,4-Dinitrophenol; Animals; Aspartic Acid; Atractyloside; Cell Respiration; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamic Acid; Laurates; Mersalyl; Mitochondria, Liver; Oxidative Phosphorylation; Palmitates; Phosphates; Rats; Temperature; Thermodynamics; Uncoupling Agents | 2003 |
Computational study on mechanistic details of the aminoethanol rearrangement catalyzed by the vitamin B12-dependent ethanolamine ammonia lyase: His and Asp/Glu acting simultaneously as catalytic auxiliaries.
Topics: Aspartic Acid; Binding Sites; Catalysis; Computational Biology; Ethanolamine Ammonia-Lyase; Ethanolamines; Glutamic Acid; Histidine; Indicators and Reagents; Molecular Conformation; Thermodynamics; Vitamin B 12 | 2003 |
Coagulation factor Va Glu-96-Asp-111: a chelator-sensitive site involved in function and subunit association.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Chelating Agents; Dimerization; Factor Va; Glutamic Acid; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Phospholipids; Protein Subunits; Thromboplastin | 2004 |
Evolution of amino acid metabolism inferred through cladistic analysis.
Topics: Amino Acids; Asparagine; Aspartic Acid; Biochemical Phenomena; Biochemistry; Biological Evolution; Citric Acid Cycle; Enzymes; Glutamic Acid; Glutamine; Models, Biological; Multigene Family; Phylogeny; Software; Statistics as Topic; Substrate Specificity | 2003 |
13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line.
Topics: Animals; Aspartic Acid; Carbon Isotopes; Clone Cells; gamma-Glutamylcyclotransferase; Glucose; Glutamic Acid; Glutamine; Islets of Langerhans; Magnetic Resonance Spectroscopy; Models, Biological | 2003 |
Metabolic changes in the vicinity of brain contusions: a proton magnetic resonance spectroscopy and histology study.
Topics: Animals; Aspartic Acid; Biomarkers; Brain Injuries; Choline; Creatine; Functional Laterality; Glutamic Acid; Immunohistochemistry; Inositol; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Protons; Rats; Rats, Sprague-Dawley; Taurine; Time Factors | 2003 |
Reaction of aspartate aminotransferase with C5-dicarboxylic acids: comparison with the reaction with C4-dicarboxylic acids.
Topics: Aspartate Aminotransferases; Aspartic Acid; Escherichia coli; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Protein Binding; Spectrophotometry; Substrate Specificity; Thermodynamics | 2003 |
Amino acid composition of brain cysts: levels of excitatory amino acids in cyst fluid fail to predict seizures.
Topics: Adenosine; Adolescent; Adult; Anticonvulsants; Aspartic Acid; Brain; Child; Cysts; Electroencephalography; Epilepsy; Excitatory Amino Acids; Female; Glutamic Acid; Humans; Male; Middle Aged; Time Factors | 2003 |
Mechanisms in enzymatic transamination; variables in the spectrophotometric estimation of glutamate-aspartate kinetics.
Topics: Aspartic Acid; Glutamates; Glutamic Acid; Kinetics; Spectrophotometry; Transaminases | 1952 |
Mechanisms in enzymatic transamination; kinetic studies of the glutamate-aspartate reaction.
Topics: Aspartic Acid; Glutamates; Glutamic Acid; Kinetics; Transaminases | 1952 |
Studies on permeability in relation to nerve function. IV. Effect of glutamate and aspartate upon the rate of entrance of potassium into brain cortical slices.
Topics: Aspartic Acid; Brain; Cerebral Cortex; Glutamates; Glutamic Acid; Permeability; Potassium | 1952 |
The effects of tobacco mosaic virus synthesis on the free amino acid and amide composition of the host.
Topics: Amides; Amino Acids; Anesthetics, Local; Aspartic Acid; Glutamic Acid; Nitrogen; Proteins; Tobacco Mosaic Virus; Viruses | 1953 |
Mechanisms in enzymatic transamination; estimation of velocity of the glutamate-aspartate reaction at equilibrium.
Topics: Aspartic Acid; Glutamates; Glutamic Acid; Transaminases | 1953 |
The metabolic conversion of the carbon chain of lysine-6-C14 to glutamic acid, aspartic acid and arginine.
Topics: Arginine; Aspartic Acid; Biochemical Phenomena; Carbon; Glutamates; Glutamic Acid; Lysine | 1954 |
The influence of amino acids on mitotic activity in fibroblast cultures. III. Effect of glutamic acid and aspartic acid.
Topics: Amino Acids; Aspartic Acid; Fibroblasts; Glutamates; Glutamic Acid; Tissue Culture Techniques | 1953 |
Glutamic acid inhibition of aspartic acid utilization in threonine biosynthesis.
Topics: Aspartic Acid; Glutamates; Glutamic Acid; Leuconostoc; Threonine | 1954 |
Metabolism of glutamic acid-1-14C and aspartic acid-4-14C in rat brain and kidney homogenates.
Topics: Animals; Aspartic Acid; Brain; Glutamic Acid; Kidney; Rats | 1954 |
[Variations in soluble methylhexabarbital in the rabbit. I. Variations in free glutamic acid and aspartic acid in the brain of the rabbit].
Topics: Animals; Aspartic Acid; Barbiturates; Body Fluids; Brain; Glutamates; Glutamic Acid; Humans; Neurochemistry; Rabbits | 1955 |
Aspartic acid inhibition of glutamic acid utilization for proline, citrulline and glutamine biosynthesis.
Topics: Amino Acids; Aspartic Acid; Biochemical Phenomena; Citrulline; Glutamates; Glutamic Acid; Glutamine; Lactobacillus; Proline | 1955 |
Distribution of glutamine, glutamic acid and aspartic acid between erythrocytes and plasma.
Topics: Amino Acids; Aspartic Acid; Blood; Erythrocytes; Glutamic Acid; Glutamine; Humans | 1956 |
[Study on the decarboxylation of L-cysteinesulfinic acid, L-cysteic acid, and L-glutamic acid by various organs of rabbits; influence of pyridoxal phosphate and thiol groups].
Topics: Animals; Aspartic Acid; Biochemical Phenomena; Coenzymes; Cysteic Acid; Cysteine; Decarboxylation; Glutamates; Glutamic Acid; Pyridoxal Phosphate; Rabbits; Sulfhydryl Compounds | 1956 |
The formation of hydroxyaspartic acid from dihydroxyfumaric acid and L-glutamic acid.
Topics: Aspartic Acid; Fumarates; Glutamates; Glutamic Acid; Maleates | 1956 |
Studies on wheat plants using C14 compounds. IV. Distribution of C14 in glutamic acid, aspartic acid, and threonine arising from acetate-1-C14 and -2-C14.
Topics: Acetates; Aspartic Acid; Carbon; Dietary Fats, Unsaturated; Glutamic Acid; Metabolism; Plant Oils; Threonine; Triticum | 1957 |
The incorporation of non-carboxyl carbon into glutamic acid, alanine, and aspartic acid by the rat.
Topics: Alanine; Animals; Aspartic Acid; Carbon; Glutamates; Glutamic Acid; Rats | 1958 |
[Aspartic acid-glutamic acid transaminase in Mycobacterium phlei].
Topics: Aspartic Acid; Glutamic Acid; Mycobacterium; Mycobacterium phlei; Transaminases | 1957 |
[Aspartic acid, glutamic acid and alanine content of heart, diaphragm and skeletal muscles in fasting guinea pigs].
Topics: Alanine; Aspartic Acid; Diaphragm; Fasting; Glutamates; Glutamic Acid; Guinea Pigs; Heart; Muscle, Skeletal; Muscles; Myocardium | 1958 |
[Effect of aspartic acid and glutamic acid hydrazides on Mycobacterium tuberculosis. I. Effect of aspartic acid hydrazide on Mycobacterium tuberculosis cultures].
Topics: Anti-Bacterial Agents; Aspartic Acid; Glutamic Acid; Hydrazines; Mycobacterium tuberculosis | 1958 |
[Effect of thyroxin on the oxidation of succinate. III. Formation of aspartic acid and alpha-ketoglutaric acid by the addition of glutamate].
Topics: Aspartic Acid; Glutamates; Glutamic Acid; Keto Acids; Ketoglutaric Acids; Ketones; Myocardium; Oxidation-Reduction; Succinates; Succinic Acid; Thyroxine | 1959 |
Some physiological aspects of glutamate-aspartate transamination in insects.
Topics: Amination; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Insecta; Transaminases | 1961 |
The effect of growth hormone on the incorporation of N15 from ammonium citrate, glycine, L-aspartic acid, L-alanine and L-glutamic acid into amino acids of liver protein.
Topics: Alanine; Amino Acids; Aspartic Acid; Citrates; Citric Acid; Glutamic Acid; Glycine; Growth Hormone; Human Growth Hormone; Liver; Proteins; Quaternary Ammonium Compounds | 1961 |
[The effect of isoniazid on glycide matabolism. VIII. On the effect of isoniazid and hydrazine hydrochloride on the glutamic acid and aspartic acid content of the rat liver].
Topics: Animals; Aspartic Acid; Epoxy Compounds; Glutamic Acid; Hydrazines; Isoniazid; Liver; Propanols; Rats; Transaminases | 1962 |
[Studies on the regulatory mechanism of insulin secretion. Insulin secretion following administration of ethanol. d-xylose, fructose. Na-asparatate and Na-glutamate].
Topics: Aspartic Acid; Ethanol; Fructose; Glutamates; Glutamic Acid; Insulin; Xylose | 1963 |
Heat capacities from 11 to 305 degree K, entropies and free energies of formation of L-asparagine monohydrate, L-aspartic acid, L-glutamic acid, and L-glutamine.
Topics: Asparagine; Aspartic Acid; Entropy; Glutamates; Glutamic Acid; Glutamine; Hot Temperature | 1963 |
Gamma irradiation of polypeptides: transformation of amino acids.
Topics: Alanine; Amino Acids; Aspartic Acid; Glutamates; Glutamic Acid; Glycine; Histidine; Methionine; Peptides; Phenylalanine; Proline; Radiation Effects; Tyrosine | 1963 |
[Aspartic semi-aldehyde dehydrogenase of Saccharomyces cerevisiae. Activation by L-aspartate and L-glutamate].
Topics: Aldehyde Dehydrogenase; Aspartic Acid; Glutamates; Glutamic Acid; Oxidoreductases; Saccharomyces cerevisiae; Xylose | 1963 |
The action of L-glutamic acid and of structurally related compounds on the hind gut of the crayfish.
Topics: Animals; Aspartic Acid; Astacoidea; Glutamates; Glutamic Acid; Muscle, Smooth; Muscles | 1962 |
The metabolism of glutamate and aspartate in rat cerebral cortical slices.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; Rats | 1962 |
FLUOROACETATE INHIBITION OF AMINO ACIDS DURING PHOTOSYNTHESIS OF CHLAMYDOMONAS REINHARDTI.
Topics: Amino Acids; Antimetabolites; Aspartic Acid; Chlamydomonas reinhardtii; Citric Acid Cycle; Eukaryota; Fluoroacetates; Glutamates; Glutamic Acid; Metabolism; Photosynthesis; Proteins; Research | 1964 |
SYNTHESIS OF GLUTAMATE FROM ALPHA-OXOGLUTARATE AND AMMONIA IN RAT-LIVER MITOCHONDRIA. III. MALATE AS HYDROGEN DONOR.
Topics: Adenosine Triphosphate; Ammonia; Amobarbital; Anti-Bacterial Agents; Aspartic Acid; Dinitrophenols; Enzyme Inhibitors; Glutamates; Glutamic Acid; Hydrogen; Ketoglutaric Acids; Liver; Malates; Mitochondria; Mitochondria, Liver; NAD; Oligomycins; Pharmacology; Rats; Research | 1963 |
THE BIOSYNTHESIS OF ASPARAGINE IN THE ETIOLATED SOYBEAN SEEDLING. II. CONVERSION IN VITRO OF GLUTAMIC ACID AND ASPARTIC ACID TO ASPARAGINE.
Topics: Asparagine; Aspartate Aminotransferases; Aspartic Acid; Darkness; Glutamates; Glutamic Acid; Glycine max; In Vitro Techniques; Plant Proteins; Proteins; Research; Seedlings | 1963 |
EFFECT OF INSULIN IN VITRO ON INCORPORATION OF 14-D FROM PYRUVATE INTO THE PROTEIN OF ISOLATED RAT DIAPHRAGM IN THE PRESENCE OF (12-CALANINE,(12-C)ASPARTIC ACID AND(12-C)GLUTAMIC ACID.
Topics: Alanine; Aspartic Acid; Biological Transport; Carbon Isotopes; Diaphragm; Glutamates; Glutamic Acid; In Vitro Techniques; Insulin; Muscles; Pharmacology; Proteins; Pyruvates; Pyruvic Acid; Rats; Research | 1964 |
THE CONVERSION OF GLUTAMATE CARBON TO FATTY ACID CARBON VIA CITRATE. I. THE INFLUENCE OF GLUCOSE IN LACTATING RAT MAMMARY GLAND SLICES.
Topics: Acetates; Animals; Aspartic Acid; Carbon; Carbon Dioxide; Carbon Isotopes; Citrates; Citric Acid; Citric Acid Cycle; Fatty Acids; Female; Glucose; Glutamates; Glutamic Acid; Humans; Ketoglutaric Acids; Lactation; Lipid Metabolism; Mammary Glands, Animal; Mammary Glands, Human; Proteins; Rats; Research | 1964 |
PATHWAY OF GLUTAMATE OXIDATION IN RAT-LIVER MITOCHONDRIA.
Topics: Ammonia; Aspartic Acid; Glutamates; Glutamic Acid; Glutarates; Liver; Malonates; Metabolism; Mitochondria; Mitochondria, Liver; Oxidation-Reduction; Pharmacology; Rats; Research | 1964 |
A STUDY ON THE "IN VITRO" SYNTHESIS OF CITRULLINE. II. EFFECT OF GLUTAMIC ACID AND DERIVATIVES IN THE PRESENCE OF FUMARIC ACID.
Topics: Acetates; Amino Acids; Antimetabolites; Aspartic Acid; Carbamates; Carbon Dioxide; Citric Acid Cycle; Citrulline; Fumarates; Glutamates; Glutamic Acid; In Vitro Techniques; Liver; Pharmacology; Rats; Research | 1964 |
AMINO GROUP FORMATION AND GLUTAMATE SYNTHESIS IN STREPTOCOCCUS BOVIS.
Topics: Amino Acids; Asparagine; Aspartic Acid; Carbon; Caseins; Culture Media; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glyceraldehyde-3-Phosphate Dehydrogenases; Isocitrate Dehydrogenase; Metabolism; NAD; NADP; Nitrogen; Nucleotides; Research; Streptococcus; Streptococcus bovis | 1964 |
[ROLE OF GLUTAMIC DEHYDROGENASE AND ASPARTIC/GLUTAMIC TRANSAMINASE IN THE OXIDATION OF GLUTAMATE BY SARCOSOMES FROM PIG HEART AND UTERUS].
Topics: Amino Acids; Animals; Antimetabolites; Arsenicals; Aspartate Aminotransferases; Aspartic Acid; Chromatography; Cytoplasmic Granules; Female; Formates; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Humans; Malonates; Manometry; Metabolism; Mitochondria, Muscle; Muscle, Smooth; Myocardium; NAD; Pharmacology; Research; Swine; Uterus | 1964 |
THE EXCITATION AND DEPRESSION OF MAMMALIAN CORTICAL NEURONES BY AMINO ACIDS.
Topics: Acetates; Amino Acids; Aminocaproates; Aminocaproic Acid; Animals; Aspartic Acid; Butyrates; Caprylates; Cats; Central Nervous System; Cerebral Cortex; Glutamic Acid; Hydroxybutyrates; N-Methylaspartate; Neurons; Pharmacology; Propionates; Research; Spinal Cord; Sulfonic Acids; Taurine | 1964 |
RELATIONSHIP OF CARBON DIOXIDE TO ASPARTIC ACID AND GLUTAMIC ACID IN ACTINOMYCES NAESLUNDII.
Topics: Actinomyces; Amino Acids; Aspartic Acid; Carbohydrate Metabolism; Carbon Dioxide; Carbon Isotopes; Fermentation; Glucose; Glutamates; Glutamic Acid; Research; Succinates | 1965 |
[ACTIVITY OF GLUTAMATE ASPARTATE AND GLUTAMINE ALANINE TRANSAMINASES IN HUMAN FETAL TISSUES].
Topics: Alanine; Alanine Transaminase; Aspartate Aminotransferases; Aspartic Acid; D-Alanine Transaminase; Fetus; Glutamic Acid; Glutamine; Humans; Metabolism; Transaminases | 1964 |
CONTROL OF GLUTAMATE METABOLISM. THE EFFECT OF PYRUVATE.
Topics: Alanine; Aspartate Aminotransferases; Aspartic Acid; Brain; Carbon Isotopes; Glutamates; Glutamic Acid; Keto Acids; Liver; Lyases; Mitochondria; Oxaloacetates; Pyruvates; Pyruvic Acid; Radiometry; Research | 1965 |
AMINO ACID UTILIZATION BY ALCALIGENES VISCOLACTIS FOR GROWTH AND SLIME PRODUCTION.
Topics: Alcaligenes; Amino Acids; Asparagine; Aspartic Acid; Carbohydrate Metabolism; Colorimetry; Culture Media; Glucose; Glutamic Acid; Glutamine; Lactose; Nitrogen; Proline; Research; Salts; Tyrosine | 1965 |
THE EFFECT OF GLUTAMIC ACID ANALOGS ON THE BIOSYNTHESIS AND CATALYTIC ACTIVITY OF GLUTAMIC ACID DECARBOXYLASE IN ESCHERICHIA COLI.
Topics: Aspartic Acid; Carboxy-Lyases; Enzyme Inhibitors; Escherichia coli; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Glutarates; Ketoglutaric Acids; Metabolism; Research | 1965 |
GAS CHROMATOGRAPHY OF VOLATILE AMINO ACID DERIVATIVES. II. LEUCINE, CYSTEINE, PROLINE, HYDROXYPROLINE, METHIONINE, PHENYLALANINE, ASPARTIC ACID AND GLUTAMIC ACID.
Topics: Arginine; Aspartic Acid; Chromatography; Chromatography, Gas; Cysteine; Glutamates; Glutamic Acid; Hydroxyproline; Leucine; Methionine; Phenylalanine; Proline; Research | 1965 |
ACTION OF GLUTAMIC ACID AND OTHER NATURALLY OCCURRING AMINO-ACIDS ON SNAIL CENTRAL NEURONS.
Topics: Acetylcholine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cysteine; Electrophysiology; Glutamates; Glutamic Acid; Helix, Snails; Iontophoresis; Neural Conduction; Neurons; Pharmacology; Research; Sensory Receptor Cells; Snails | 1964 |
METABOLISM OF PROPIONATE BY SHEEP LIVER. INTERRELATIONS OF PROPIONATE AND GLUTAMATE IN AGED MITOCHONDRIA.
Topics: Acyl Coenzyme A; Aging; Amino Acids; Animals; Aspartic Acid; Carbon Dioxide; Citrates; Fatty Acids; Fumarates; Glutamates; Glutamic Acid; Ketoglutaric Acids; Liver; Malates; Mitochondria; Mitochondria, Liver; Oxaloacetates; Pharmacology; Propionates; Pyruvates; Research; Sheep; Sheep, Domestic; Succinates | 1965 |
INTERACTION OF ASPARTATE AMINOTRANSFERASE WITH AMINO ACIDS.
Topics: Adipates; Aldehydes; Amines; Amino Acids; Aspartate Aminotransferases; Aspartic Acid; Chemical Phenomena; Chemistry; Glutamates; Glutamic Acid; Pimelic Acids; Research | 1965 |
The thermal copolymerization of aspartic acid and glutamic acid.
Topics: Aspartic Acid; Glutamates; Glutamic Acid; Polymerization | 1960 |
The interconversion of glutamic acid and aspartic acid in respiring tissues.
Topics: Aspartic Acid; Cell Respiration; Glutamates; Glutamic Acid | 1960 |
Utilization and transfer of nitrogen from glycine, 1-alanine, 1-glutamic acid and 1-aspartic acid during cessation and induction of growth.
Topics: Alanine; Aspartic Acid; Biochemical Phenomena; Glutamates; Glutamic Acid; Glycine; Growth Hormone; Nitrogen | 1959 |
Studies on mucoproteins. VII. The linkage of the prosthetic group to aspartic and glutamic acid residues in bovine submaxillary gland mucoprotein.
Topics: Animals; Aspartic Acid; Cattle; Genetic Linkage; Glutamates; Glutamic Acid; Mucoproteins; Submandibular Gland | 1961 |
The N-terminal amino acids of human plasma proteins.
Topics: Alanine; Amino Acids; Aspartic Acid; Blood Proteins; Glutamic Acid; Glycine; Humans; Leucine; Nuclear Receptor Subfamily 4, Group A, Member 2; Tyrosine; Valine | 1962 |
The effect of sevoflurane and propofol on cerebral neurotransmitter concentrations during cerebral ischemia in rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Aspartic Acid; Blood Gas Analysis; Blood Pressure; Brain Chemistry; Brain Ischemia; Catecholamines; Chromatography, High Pressure Liquid; Electroencephalography; Epinephrine; Glutamic Acid; Hypotension; Male; Methyl Ethers; Neuroprotective Agents; Neurotransmitter Agents; Norepinephrine; Propofol; Rats; Rats, Sprague-Dawley; Reperfusion; Sevoflurane | 2003 |
The crystal structure of Escherichia coli heat shock protein YedU reveals three potential catalytic active sites.
Topics: Amino Acid Motifs; Amino Acid Sequence; Aspartic Acid; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Cysteine; Dimerization; Electronic Data Processing; Escherichia coli Proteins; Glutamic Acid; Heat-Shock Proteins; Histidine; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Chaperones; Molecular Sequence Data; Protein Structure, Quaternary; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Structural Homology, Protein; Zinc | 2003 |
Molecular basis of ion selectivity, block, and rectification of the inward rectifier Kir3.1/Kir3.4 K(+) channel.
Topics: Animals; Aspartic Acid; Base Sequence; DNA Primers; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Glutamic Acid; Ions; Mutagenesis, Site-Directed; Oocytes; Potassium Channels; Potassium Channels, Inwardly Rectifying | 2003 |
A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors.
Topics: Alfaxalone Alfadolone Mixture; Animals; Aspartic Acid; Brain Chemistry; Brain Mapping; Case-Control Studies; Choline; Creatine; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; Macaca radiata; Magnetic Resonance Spectroscopy; Male; Stress, Psychological; Temporal Lobe | 2003 |
Beta-amyloid prevents excitotoxicity via recruitment of glial glutamate transporters.
Topics: Amino Acid Transport System X-AG; Amyloid beta-Peptides; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Colorimetry; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Peptide Fragments; Rats; Rats, Wistar | 2003 |
In vivo simultaneous monitoring of gamma-aminobutyric acid, glutamate, and L-aspartate using brain microdialysis and capillary electrophoresis with laser-induced fluorescence detection: Analytical developments and in vitro/in vivo validations.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Aspartic Acid; beta-Cyclodextrins; Brain Chemistry; Buffers; Chromatography, Micellar Electrokinetic Capillary; Cyclodextrins; Dialysis Solutions; Electrophoresis, Capillary; Fluorescence; gamma-Aminobutyric Acid; gamma-Cyclodextrins; Glutamic Acid; Hydrogen-Ion Concentration; Lasers; Microdialysis; Naphthalenes; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Sodium Dodecyl Sulfate; Time Factors | 2003 |
Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus.
Topics: Aging; Animals; Aspartic Acid; Body Weight; Brain; Brain Chemistry; Creatine; Ethanolamines; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Iron; Iron Deficiencies; Liver; Magnetic Resonance Spectroscopy; Male; Myocardium; Organ Size; Phosphocreatine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Taurine | 2003 |
Identification of Pseudomonas proteins coordinately induced by acidic amino acids and their amides: a two-dimensional electrophoresis study.
Topics: Asparaginase; Asparagine; Aspartic Acid; Bacterial Proteins; Glutamic Acid; Glutaminase; Glutamine; Periplasm; Proteomics; Pseudomonas fluorescens; Pseudomonas putida; Reverse Transcriptase Polymerase Chain Reaction; Sigma Factor | 2003 |
Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design.
Topics: Aspartic Acid; Base Sequence; Binding Sites; Crystallography, X-Ray; Drug Design; Escherichia coli; Glutamic Acid; Models, Molecular; Molecular Sequence Data; Pentosyltransferases; Peptides; Protein Folding; RNA, Transfer; Substrate Specificity; Zymomonas | 2003 |
Metabolic changes in the knockout mouse for Canavan's disease: implications for patients with Canavan's disease.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Body Weight; Canavan Disease; Disease Models, Animal; Glutamic Acid; Humans; Mice; Mice, Knockout | 2003 |
Serial proton magnetic resonance spectroscopy of the brain in children undergoing cardiac surgery.
Topics: Aspartic Acid; Brain; Cardiopulmonary Bypass; Child, Preschool; Glutamic Acid; Glutamine; Heart Defects, Congenital; Hematocrit; Humans; Infant; Inositol; Magnetic Resonance Spectroscopy; Occipital Lobe; Thoracic Surgery; Ultrasonography, Doppler, Transcranial | 2003 |
Interactions between charged amino acid residues within transmembrane helices in the sulfate transporter SHST1.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amino Acids; Arginine; Aspartic Acid; Carrier Proteins; Cell Membrane; Fabaceae; Glutamic Acid; Glutamine; Growth Inhibitors; Molecular Sequence Data; Mutagenesis, Site-Directed; Plant Proteins; Protein Structure, Secondary; Protein Transport; Saccharomyces cerevisiae; Sulfates | 2003 |
Sugar recognition by human galactokinase.
Topics: Alanine; Arabidopsis Proteins; Aspartic Acid; Binding Sites; Carbohydrate Metabolism; Carbohydrates; Galactokinase; Glutamic Acid; Humans; Kinetics; Mutation; Phosphotransferases (Alcohol Group Acceptor); Solubility; Substrate Specificity | 2003 |
Morphology and ultrastructure of rat hippocampal formation after i.c.v. administration of N-acetyl-L-aspartyl-L-glutamate.
Topics: Animals; Aspartic Acid; Cell Count; Cell Death; Dipeptides; DNA Fragmentation; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; In Situ Nick-End Labeling; Injections, Intraventricular; Male; Microscopy, Electron; Nerve Degeneration; Neurons; Neuropeptides; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Time Factors | 2003 |
Drug-induced parkinsonism in relation to choline-containing compounds measured by 1H-MR spectroscopy in putamen of chronically medicated patients with schizophrenia.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Basal Ganglia Diseases; Choline; Chronic Disease; Creatine; Dominance, Cerebral; Energy Metabolism; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurologic Examination; Parkinson Disease, Secondary; Phosphocreatine; Putamen; Reference Values; Schizophrenia; Schizophrenic Psychology | 2003 |
Structural characterization of the peroxodiiron(III) intermediate generated during oxygen activation by the W48A/D84E variant of ribonucleotide reductase protein R2 from Escherichia coli.
Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Escherichia coli Proteins; Ferric Compounds; Ferrous Compounds; Glutamic Acid; Oxygen; Oxygenases; Protein Subunits; Ribonucleotide Reductases; Spectroscopy, Mossbauer; Spectrum Analysis; Tryptophan; X-Rays | 2003 |
Role of His-16 in turnover of T4 pyrimidine dimer glycosylase.
Topics: Alanine; Aspartic Acid; Cell Survival; Cysteine; Dimerization; DNA; DNA Glycosylases; DNA Repair; Escherichia coli; Glutamic Acid; Histidine; Kinetics; Lysine; Models, Biological; Mutagenesis, Site-Directed; Mutation; Oligonucleotides; Phenotype; Plasmids; Serine; Time Factors; Ultraviolet Rays | 2004 |
Endothelial nitric oxide synthase gene polymorphisms in giant cell arteritis.
Topics: Aged; Aspartic Acid; DNA; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Giant Cell Arteritis; Glutamic Acid; Heterozygote; Humans; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic | 2003 |
Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae.
Topics: Acetates; Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Carbon Dioxide; Glutamic Acid; Humans; Liposomes; Malates; Membrane Potentials; Mitochondria; Ornithine; Protein Isoforms; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2003 |
Glutamate spillover in the striatum depresses dopaminergic transmission by activating group I metabotropic glutamate receptors.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glycine; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Symporters; Synaptic Transmission | 2003 |
A pathogenic glutamate-to-aspartate substitution (D296E) in the pyruvate dehydrogenase E1 subunit gene PDHA1.
Topics: Amino Acid Substitution; Aspartic Acid; Catalytic Domain; DNA Mutational Analysis; DNA, Complementary; Fatal Outcome; Female; Fibroblasts; Glutamic Acid; Humans; Infant, Newborn; Male; Models, Molecular; Mutation; Pyruvate Dehydrogenase (Lipoamide); Pyruvate Dehydrogenase Complex Deficiency Disease | 2003 |
Effects of acute hypoxic conditions on extracellular excitatory amino acids and dopamine in the striatum of freely-moving rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acute Disease; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Excitatory Amino Acids; Extracellular Fluid; Glutamic Acid; Homovanillic Acid; Hypoglycemia; Hypoxia; Male; Motor Activity; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley | 2003 |
Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Chronic Disease; Dominance, Cerebral; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Degeneration; Psychiatric Status Rating Scales; Reference Values; Schizophrenia; Thalamus | 2003 |
Out-and-in spiral spectroscopic imaging in rat brain at 7 T.
Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Glutamic Acid; Glutamine; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Wistar | 2003 |
Chemical neuroanatomy of the fly's movement detection pathway.
Topics: Animals; Aspartic Acid; Bees; Brain Chemistry; Choline O-Acetyltransferase; Dendrites; Diptera; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Interneurons; Medulla Oblongata; Motion Perception; Neurons; Periplaneta; Photoreceptor Cells, Invertebrate; Receptors, N-Methyl-D-Aspartate; Taurine | 2004 |
Neurotrophic factors in the pathogenesis of Rett syndrome.
Topics: Adolescent; Aspartic Acid; Autistic Disorder; Brain-Derived Neurotrophic Factor; Child; Child, Preschool; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acids; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Humans; Infant; Insulin-Like Growth Factor I; Nerve Growth Factor; Nerve Growth Factors; Rett Syndrome | 2003 |
Aspartate 345 of the dopamine transporter is critical for conformational changes in substrate translocation and cocaine binding.
Topics: Alanine; Aspartic Acid; Biological Transport; Biotinylation; Blotting, Western; Cell Line; Cell Membrane; Cocaine; Cystine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Kinetics; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Mesylates; Mutation; Nerve Tissue Proteins; Phenotype; Piperazines; Protein Binding; Protein Conformation; Protein Transport; Sodium; Time Factors; Zinc | 2004 |
Role of neuronal glutamate transporter in the cysteine uptake and intracellular glutathione levels in cultured cortical neurons.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Cysteine; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Extracellular Fluid; Glutamic Acid; Glutathione; Immunohistochemistry; Neurons; Rats; Sodium | 2003 |
The Glu298-->Asp polymorphism of the endothelial nitric oxide synthase gene is associated with endometriosis.
Topics: Amino Acid Substitution; Aspartic Acid; Base Sequence; DNA Primers; Endometriosis; Female; Glutamic Acid; Humans; Introns; Mutation, Missense; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Reference Values; Risk Factors; Texas; White People | 2003 |
Increasing of intrathecal CSF excitatory amino acids concentration following morphine challenge in morphine-tolerant rats.
Topics: Analgesics, Opioid; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Injections, Spinal; Male; Microdialysis; Morphine; Pain; Pain Measurement; Rats; Rats, Wistar; Time Factors | 2004 |
A glutamate is the essential proton transfer gate during the catalytic cycle of the [NiFe] hydrogenase.
Topics: Aspartic Acid; Binding Sites; Catalysis; Catalytic Domain; Crystallography, X-Ray; Desulfovibrio; Electron Spin Resonance Spectroscopy; Glutamic Acid; Hydrogen; Hydrogen-Ion Concentration; Hydrogenase; Kinetics; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Oxygen; Plasmids; Protons; Spectroscopy, Fourier Transform Infrared; Time Factors; X-Ray Diffraction | 2004 |
Direct evidence for substrate-induced proton release in detergent-solubilized EmrE, a multidrug transporter.
Topics: Antiporters; Aspartic Acid; Biological Transport; Cell Membrane; Detergents; Dicyclohexylcarbodiimide; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Hydrogen; Hydrogen-Ion Concentration; Ions; Kinetics; Membrane Proteins; Models, Biological; Plasmids; Protein Binding; Protons | 2004 |
Mechanism of proton gating of a urea channel.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Bacterial Proteins; Biological Transport; Cell Membrane; Glutamic Acid; Helicobacter hepaticus; Helicobacter pylori; Histidine; Hydrogen-Ion Concentration; Membrane Transport Proteins; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Protein Structure, Tertiary; Protons; RNA; Sequence Homology, Amino Acid; Streptococcus; Urea; Urease; Xenopus; Xenopus laevis | 2004 |
A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Cerebrospinal Fluid; Choline; Creatine; Discriminant Analysis; Fatty Acids; Glioma; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Inositol; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Patient Selection; Principal Component Analysis; Probability; Sensitivity and Specificity; Statistical Distributions | 2003 |
Sterol methyltransferase: functional analysis of highly conserved residues by site-directed mutagenesis.
Topics: Aspartic Acid; Catalysis; Circular Dichroism; Conserved Sequence; Glutamic Acid; Methyltransferases; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Recombinant Proteins; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 2004 |
Disentangling the web of allosteric communication in a homotetramer: heterotropic inhibition of phosphofructokinase from Bacillus stearothermophilus.
Topics: Alanine; Allosteric Regulation; Allosteric Site; Arginine; Aspartic Acid; Bacterial Proteins; Binding Sites; Fructosephosphates; Geobacillus stearothermophilus; Glutamic Acid; Mutagenesis, Site-Directed; Phosphofructokinase-1; Protein Structure, Secondary; Substrate Specificity | 2004 |
Mutational and computational analysis of the role of conserved residues in the active site of a family 18 chitinase.
Topics: Aspartic Acid; Binding Sites; Catalytic Domain; Chitinases; Computational Biology; Computer Simulation; Conserved Sequence; DNA Mutational Analysis; Glutamic Acid; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Mutation; Serratia marcescens; Structure-Activity Relationship; Tyrosine | 2004 |
Neurochemical changes of the extracellular concentrations of glutamate and aspartate in the nucleus accumbens of rats after chronic administration of morphine.
Topics: Animals; Aspartic Acid; Extracellular Fluid; Glutamic Acid; Male; Morphine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 2004 |
Roles of N-terminal region residues Lys11, Arg13, and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change.
Topics: Alanine; Amino Acid Substitution; Antithrombins; Arginine; Aspartic Acid; Glutamic Acid; Heparin; Humans; Ions; Kinetics; Lysine; Oligosaccharides; Peptide Fragments; Protease Inhibitors; Protein Binding; Protein Conformation; Protein Structure, Tertiary | 2004 |
JAMM: a metalloprotease-like zinc site in the proteasome and signalosome.
Topics: Amino Acid Motifs; Animals; Archaea; Archaeoglobus fulgidus; Aspartic Acid; Binding Sites; DNA-Binding Proteins; Glutamic Acid; Histidine; Humans; Hydrogen Bonding; Metalloproteases; Molecular Sequence Data; Mutagenesis; NEDD8 Protein; Open Reading Frames; Proteasome Endopeptidase Complex; Protein Conformation; Protein Folding; Signal Transduction; Thermolysin; Transcription Factors; Ubiquitins; Zinc | 2004 |
Nitrogen metabolism in the African lungfish (Protopterus dolloi) aestivating in a mucus cocoon on land.
Topics: Africa; Alanine; Ammonia; Animals; Arginine; Aspartic Acid; Estivation; Fishes; Glutamic Acid; Time Factors; Tryptophan | 2004 |
The structure of a universally employed enzyme: V8 protease from Staphylococcus aureus.
Topics: Aspartic Acid; Binding Sites; Catalysis; Crystallography, X-Ray; Disulfides; Glutamic Acid; Models, Molecular; Peptides; Protein Structure, Secondary; Protein Structure, Tertiary; Serine; Serine Endopeptidases; Staphylococcus aureus; Trypsin; X-Ray Diffraction | 2004 |
Three-dimensional structure of kynureninase from Pseudomonas fluorescens.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Binding Sites; Crystallization; Crystallography, X-Ray; Glutamic Acid; Humans; Hydrolases; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Folding; Pseudomonas fluorescens; Pyridoxal Phosphate; Sequence Alignment; Sequence Homology, Amino Acid | 2004 |
Relation between protein stability, evolution and structure, as probed by carboxylic acid mutations.
Topics: Aspartic Acid; Evolution, Molecular; Glutamic Acid; Mutation; Protein Conformation; Proteins; Thermodynamics; Thioredoxins | 2004 |
Highly efficient renaturation of beta-lactamase isolated from moderately halophilic bacteria.
Topics: Amino Acid Sequence; Aspartic Acid; beta-Lactamases; Circular Dichroism; Cloning, Molecular; Enzyme Stability; Escherichia coli; Genes, Bacterial; Glutamic Acid; Glutathione Transferase; Halobacteriaceae; Halomonadaceae; Hot Temperature; Molecular Sequence Data; Osmolar Concentration; Protein Renaturation; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Sodium Chloride | 2004 |
Identification of two novel mutations in the Cu/Zn superoxide dismutase gene with familial amyotrophic lateral sclerosis: mass spectrometric and genomic analyses.
Topics: Age of Onset; Amyotrophic Lateral Sclerosis; Aspartic Acid; Chromatography, Liquid; DNA Mutational Analysis; Erythrocytes; Exons; Family Health; Female; Glutamic Acid; Glycine; Histidine; Humans; Male; Molecular Biology; Molecular Sequence Data; Mutation; Precipitin Tests; Spectrometry, Mass, Electrospray Ionization; Superoxide Dismutase | 2004 |
Conversion into GABA (gamma-aminobutyric acid) may reduce the capacity of L-glutamine as an insulin secretagogue.
Topics: 4-Aminobutyrate Transaminase; Adenosine Triphosphate; Allylglycine; Amination; Animals; Aspartic Acid; Baclofen; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Insulin; Insulin Secretion; Islets of Langerhans; Ketoglutaric Acids; Leucine; Male; Oxidation-Reduction; Perfusion; Potassium Chloride; Rats; Rats, Wistar; Receptors, GABA | 2004 |
Aspartate transporter expression and activity in hypertrophic rat heart and ischaemia-reperfusion injury.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Cardiomegaly; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Glutamate Dehydrogenase; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutamine; Heart; Heart Rate; Ischemia; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Male; Myocardium; Myocytes, Cardiac; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reperfusion; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; Sarcolemma; Symporters; Ventricular Pressure | 2004 |
[Choline aspartate and glutamate].
Topics: Aspartic Acid; Choline; Glutamates; Glutamic Acid; Humans | 1950 |
The aspartic-glutamic acids ratio in the metabolism of Streptococcus fecalis. I. The role of glutamic acid and biotin in synthesis of aspartic acid.
Topics: Aspartic Acid; Biotin; Enterococcus faecalis; Glutamates; Glutamic Acid; Streptococcus | 1950 |
Determination of aspartic and glutamic acids by enzymatic decarboxylation.
Topics: Aspartic Acid; Decarboxylation; Glutamates; Glutamic Acid | 1951 |
Tracer studies on the metabolism of the Gardner lymphosarcoma. IV. The conversion of lactate-2-C14 to alanine, glutamate, and aspartate by tumor and spleen cells.
Topics: Alanine; Aspartic Acid; Glutamates; Glutamic Acid; Lactic Acid; Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms; Spleen | 1951 |
The aspartic acid, glutamic acid, proline and tyrosine content of meat.
Topics: Aspartic Acid; Glutamates; Glutamic Acid; Humans; Meat; Proline; Tyrosine | 1952 |
Identification of critical residues of choline kinase A2 from Caenorhabditis elegans.
Topics: Adenosine Triphosphate; Amino Acid Motifs; Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Caenorhabditis elegans; Catalysis; Cell Line; Choline Kinase; Chromatography, Gel; Circular Dichroism; Dose-Response Relationship, Drug; Glutamic Acid; Guanidine; Insecta; Kanamycin Kinase; Kinetics; Magnesium; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Phosphotransferases; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 2004 |
Hippocampal microdialysis during spontaneous intraoperative epileptiform activity.
Topics: Adult; Aspartic Acid; Dominance, Cerebral; Electroencephalography; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; Intraoperative Period; Magnetic Resonance Imaging; Male; Microdialysis; Sclerosis; Surgery, Computer-Assisted | 2004 |
Glutamate, but not aspartate, is enriched in trigeminothalamic tract terminals and associated with their synaptic vesicles in the rat nucleus submedius.
Topics: Animals; Aspartic Acid; Glutamic Acid; Male; Neural Pathways; Rats; Rats, Sprague-Dawley; Synaptic Vesicles; Thalamus; Trigeminal Nuclei | 2004 |
Mutational analysis of different regions in the coxsackievirus 2B protein: requirements for homo-multimerization, membrane permeabilization, subcellular localization, and virus replication.
Topics: Amino Acid Sequence; Animals; Arginine; Asparagine; Aspartic Acid; Cell Line; Cell Membrane; Chlorocebus aethiops; COS Cells; Dimerization; DNA Mutational Analysis; Enterovirus; Glutamic Acid; Hygromycin B; Kinetics; Lysine; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; Oligonucleotides, Antisense; Permeability; Protein Structure, Tertiary; RNA; Subcellular Fractions; Time Factors; Transfection; Tryptophan; Two-Hybrid System Techniques; Viral Nonstructural Proteins; Virus Replication | 2004 |
The composition rather than position of polar residues (QxxS) drives aspartate receptor transmembrane domain dimerization in vivo.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Bacterial Proteins; Chemoreceptor Cells; Dimerization; DNA-Binding Proteins; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Glutamic Acid; Glutamine; Membrane Proteins; Molecular Sequence Data; Periplasmic Binding Proteins; Protein Structure, Tertiary; Receptors, Amino Acid; Receptors, Cell Surface; Recombinant Fusion Proteins; Serine; Transcription Factors | 2004 |
The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid; Biological Transport; Cell Membrane Permeability; Chlorides; Cloning, Molecular; Excitatory Amino Acid Transporter 1; Female; Glutamic Acid; Kinetics; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Peptide Fragments; Protein Conformation; Recombinant Proteins; Sequence Alignment; Xenopus laevis | 2004 |
Radiolytic modification of acidic amino acid residues in peptides: probes for examining protein-protein interactions.
Topics: Aspartic Acid; Decarboxylation; Glutamic Acid; Molecular Structure; Oxidation-Reduction; Peptides; Protein Binding; Proteins; Spectrometry, Mass, Electrospray Ionization | 2004 |
Neurometabolic functioning and neuropsychological correlates in children with ADHD-H: preliminary findings.
Topics: Aspartic Acid; Attention; Attention Deficit Disorder with Hyperactivity; Brain Chemistry; Case-Control Studies; Child; Choline; Creatine; Female; Frontal Lobe; Functional Laterality; Glutamic Acid; Glutamine; Humans; Language; Learning; Magnetic Resonance Spectroscopy; Male; Motor Activity; Neuropsychological Tests; Psychomotor Performance | 2004 |
Role of astrocytes in depolarization-coupled release of glutamate in cerebellar cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebellum; Glutamic Acid; Mice; Nocodazole | 2004 |
Identification of glutamate transporters and receptors in mouse testis.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Brain; Cells, Cultured; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; GluK2 Kainate Receptor; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Symporters; Synaptosomes; Testis | 2004 |
Measurement of brain glutamate using TE-averaged PRESS at 3T.
Topics: Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Dipeptides; Female; Fourier Analysis; Glutamic Acid; Glutamine; Humans; Image Enhancement; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropeptides; Reproducibility of Results | 2004 |
Binding ability of a HHP-tagged protein towards Ni2+ studied by paramagnetic NMR relaxation: the possibility of obtaining long-range structure information.
Topics: Aspartic Acid; Dimerization; Escherichia coli; Glutamic Acid; Histidine; Models, Theoretical; Nickel; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Structure, Tertiary; Protons; Recombinant Fusion Proteins; Thioredoxins | 2004 |
Poorer cognitive performance in humans with mild cognitive impairment carrying the T variant of the Glu/Asp NOS3 polymorphism.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Aspartic Acid; Chi-Square Distribution; Cognition Disorders; Female; Genetic Variation; Genotype; Glutamic Acid; Humans; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Odds Ratio; Polymorphism, Genetic | 2004 |
Volume-regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbra.
Topics: Amino Acid Transport System X-AG; Animals; Anion Transport Proteins; Aspartic Acid; Astrocytes; Brain Ischemia; Cerebral Cortex; Excitatory Amino Acids; Glutamic Acid; Infarction, Middle Cerebral Artery; Kainic Acid; Microdialysis; Neurons; Rats; Receptors, Glutamate; Tamoxifen; Taurine | 2004 |
L-Glutamate in the extracellular space regulates endogenous D-aspartate homeostasis in rat pheochromocytoma MPT1 cells.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Cell Line, Tumor; Cysteine; Extracellular Space; Glutamic Acid; Homeostasis; Neurotransmitter Agents; PC12 Cells; Pheochromocytoma; Rats | 2004 |
Evidence for the proximity of the extreme N-terminus of the neurokinin-2 (NK2) tachykinin receptor to Cys167 in the putative fourth transmembrane helix.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Benzamides; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cysteine; Ethyl Methanesulfonate; Extracellular Space; Glutamic Acid; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Piperidines; Protein Structure, Secondary; Receptors, Neurokinin-2; Static Electricity; Sulfhydryl Reagents; Tritium | 2004 |
Proton release and uptake of pharaonis phoborhodopsin (sensory rhodopsin II) reconstituted into phospholipids.
Topics: Amino Acid Substitution; Archaeal Proteins; Aspartic Acid; Bacteriorhodopsins; Carboxylic Acids; Carotenoids; Glutamic Acid; Halorhodopsins; Hydrogen-Ion Concentration; Light; Natronobacterium; Phosphatidylcholines; Photolysis; Photoreceptors, Microbial; Proline; Protons; Sensory Rhodopsins | 2004 |
alpha-Tropomyosin mutations Asp(175)Asn and Glu(180)Gly affect cardiac function in transgenic rats in different ways.
Topics: Animals; Animals, Genetically Modified; Asparagine; Aspartic Acid; Biomarkers; Calcium; Cardiomyopathy, Hypertrophic, Familial; Gene Expression; Glutamic Acid; Glycine; Heart; Heart Ventricles; Humans; Immunohistochemistry; In Vitro Techniques; Muscle Fibers, Skeletal; Mutation, Missense; Myocardial Contraction; Myocytes, Cardiac; Rats; Sarcomeres; Transgenes; Tropomyosin | 2004 |
Pyridoxine-dependent seizures: magnetic resonance spectroscopy findings.
Topics: Aspartic Acid; Brain Damage, Chronic; Child; Choline; Consanguinity; Creatine; Diagnosis, Differential; Epilepsy, Generalized; Female; Follow-Up Studies; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Intellectual Disability; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Occipital Lobe; Parietal Lobe; Phosphocreatine; Pyridoxine; Reference Values; Vitamin B 6 Deficiency | 2004 |
[Effects of estradiol on deltamethrin-induced neurotoxicity in rat cerebro-cortical synaptosomes].
Topics: Animals; Aspartic Acid; Cerebral Cortex; Estradiol; Glutamic Acid; Insecticides; Neurotoxicity Syndromes; Nitriles; Pyrethrins; Rats; Rats, Wistar; Synaptosomes | 2004 |
A (13)C isotopomer kinetic analysis of cardiac metabolism: influence of altered cytosolic redox and [Ca(2+)](o).
Topics: Animals; Aspartic Acid; Calcium; Carbon Isotopes; Citric Acid Cycle; Cytosol; Glutamic Acid; Heart Rate; Kinetics; Lactic Acid; Magnetic Resonance Spectroscopy; Malates; Male; Myocardium; Osmolar Concentration; Oxidation-Reduction; Oxygen Consumption; Pressure; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Ventricular Function, Left | 2004 |
Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk.
Topics: Adult; Aged; Alleles; Arginine; Aspartic Acid; Codon; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Binding Proteins; Environment; Female; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Glutamine; Humans; Japan; Lung Neoplasms; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic; Risk; Risk Factors; Smoking; X-ray Repair Cross Complementing Protein 1 | 2004 |
Use of methotrexate-based peptide substrates to characterize the substrate specificity of prostate-specific membrane antigen (PSMA).
Topics: Animals; Antigens, Surface; Aspartic Acid; Blotting, Western; Extracellular Fluid; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Immunoglobulin gamma-Chains; Immunoglobulin kappa-Chains; Male; Methotrexate; Mice; Peptide Fragments; Prodrugs; Prostatic Neoplasms; Recombinant Fusion Proteins; Substrate Specificity; Tumor Cells, Cultured | 2004 |
Electrophilic amination of amino acids with N-Boc-oxaziridines: efficient preparation of N-orthogonally diprotected hydrazino acids and piperazic acid derivatives.
Topics: Amination; Amino Acids; Aspartic Acid; Aziridines; Catalysis; Combinatorial Chemistry Techniques; Electrochemistry; Glutamic Acid; Hydrazines; Indicators and Reagents; Molecular Structure; Pyridazines; Stereoisomerism | 2004 |
Glutamate concentrations in human brain using single voxel proton magnetic resonance spectroscopy at 3 Tesla.
Topics: Adult; Aspartic Acid; Brain; Brain Mapping; Female; Fourier Analysis; Glutamic Acid; Glutamine; Gyrus Cinguli; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Reference Values; Statistics as Topic | 2004 |
Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism.
Topics: Aspartic Acid; Autistic Disorder; Chromosome Mapping; Chromosomes, Human, Pair 2; DNA Mutational Analysis; DNA, Mitochondrial; Genetic Linkage; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Haplotypes; Humans; Membrane Transport Proteins; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Point Mutation; Polymorphism, Genetic | 2004 |
Glutamate transporters prevent the generation of seizures in the developing rat neocortex.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Biological Clocks; Calcium Signaling; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Neocortex; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2004 |
Detection of a homozygous D645E mutation of the acid alpha-glucosidase gene and glycogen deposition in tissues in a second-trimester fetus with infantile glycogen storage disease type II.
Topics: Adult; alpha-Glucosidases; Aspartic Acid; Female; Glutamic Acid; Glycogen; Glycogen Storage Disease Type II; Homozygote; Humans; Lysosomes; Mutation; Pregnancy; Pregnancy Trimester, Second | 2004 |
Glutamate release increases during mossy-CA3 LTP but not during Schaffer-CA1 LTP.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Calcium; Colforsin; Coloring Agents; Cyclopropanes; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Long-Term Potentiation; Magnesium; Male; Mossy Fibers, Hippocampal; Neuroglia; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
A truncated aminoacyl-tRNA synthetase modifies RNA.
Topics: Adenosine; Amino Acyl-tRNA Synthetases; Aspartic Acid; Escherichia coli Proteins; Glutamate-tRNA Ligase; Glutamic Acid; Nucleoside Q; RNA; RNA, Transfer, Asp | 2004 |
The determinants of carboxyl pKa values in turkey ovomucoid third domain.
Topics: Animals; Aspartic Acid; Computational Biology; Glutamic Acid; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Structure; Ovomucin; Protein Structure, Tertiary; Turkeys | 2004 |
Differential release of neurotransmitters from superficial and deep layers of the dorsal horn in response to acute noxious stimulation and inflammation of the rat paw.
Topics: Afferent Pathways; Animals; Arginine; Aspartic Acid; Chondrus; Extracellular Fluid; Foot; gamma-Aminobutyric Acid; Glutamic Acid; Inflammation; Male; Microdialysis; Neurotransmitter Agents; Pain; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Wistar; Reaction Time; Synaptic Transmission; Up-Regulation | 2004 |
Extracellular taurine in the substantia nigra: taurine-glutamate interaction.
Topics: Adrenergic Agents; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Chemistry; Calcium; Chelating Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Excitatory Amino Acid Antagonists; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Ketamine; Male; Membrane Potentials; Microdialysis; N-Methylaspartate; Oxidopamine; Potassium; Rats; Rats, Sprague-Dawley; Substantia Nigra; Taurine; Time Factors; Zinc | 2004 |
A single amino-acid polymorphism in pocket A of HLA-A*6602 alters the auxiliary anchors compared with HLA-A*6601 ligands.
Topics: Arginine; Aspartic Acid; Chromatography, Affinity; Glutamic Acid; HLA-A Antigens; Humans; Ligands; Peptide Fragments; Polymorphism, Genetic; Protein Binding; Recombinant Proteins; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
GABAergic synapses in hippocampus exocytose aspartate on to NMDA receptors: quantitative immunogold evidence for co-transmission.
Topics: Animals; Aspartic Acid; Dentate Gyrus; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Immunohistochemistry; In Vitro Techniques; Male; Microscopy, Electron; Neural Inhibition; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Membranes; Synaptic Transmission; Synaptic Vesicles | 2004 |
Domain structures and roles in bacteriophage HK97 capsid assembly and maturation.
Topics: Asparagine; Aspartic Acid; Capsid; Coliphages; Crystallization; Cysteine; Glutamic Acid; Lysine; Protein Precursors; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Spectrum Analysis, Raman; Tryptophan; Tyrosine; Virus Assembly | 2004 |
Extracellular excitatory amino acids increase in the paraventricular nucleus of male rats during sexual activity: main role of N-methyl-d-aspartic acid receptors in erectile function.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Analysis of Variance; Animals; Aspartic Acid; Behavior, Animal; Copulation; Dialysis; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Penile Erection; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Sexual Behavior, Animal | 2004 |
Long-range nature of the interactions between titratable groups in Bacillus agaradhaerens family 11 xylanase: pH titration of B. agaradhaerens xylanase.
Topics: Aspartic Acid; Bacillus; Bacterial Proteins; Carboxylic Acids; Endo-1,4-beta Xylanases; Glutamic Acid; Histidine; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Imidazoles; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protons; Recombinant Proteins; Static Electricity; Titrimetry | 2004 |
Identification of the catalytic residues involved in the carboxyl transfer of pyruvate carboxylase.
Topics: Acetyl-CoA Carboxylase; Aspartic Acid; Bacillus; Carboxy-Lyases; Carboxyl and Carbamoyl Transferases; Carrier Proteins; Catalytic Domain; Chromatography, Gel; Chromatography, High Pressure Liquid; Circular Dichroism; Conserved Sequence; Enzyme Activation; Fatty Acid Synthase, Type II; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Lysine; Mutagenesis, Site-Directed; Oxamic Acid; Protein Structure, Tertiary; Pyruvate Carboxylase; Pyruvic Acid; Tritium | 2004 |
Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
Topics: Animals; Aspartic Acid; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Naphthalenes; Neurons; Patch-Clamp Techniques; Protein Kinase C; Pyramidal Cells; Rats; Receptors, Kainic Acid; Signal Transduction; Synapses | 2004 |
NR2B-containing receptors mediate cross talk among hippocampal synapses.
Topics: Afferent Pathways; Animals; Aspartic Acid; Diffusion; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses | 2004 |
Targeting prostate-specific membrane antigen in cancer therapy: can molecular medicine be brought to the surface?
Topics: Antigens, Surface; Aspartic Acid; Drug Delivery Systems; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Male; Methotrexate; Peptide Fragments; Prodrugs; Prostatic Neoplasms; Recombinant Fusion Proteins; Substrate Specificity | 2004 |
Mutations of charged amino acids in or near the transmembrane helices of the second membrane spanning domain differentially affect the substrate specificity and transport activity of the multidrug resistance protein MRP1 (ABCC1).
Topics: Amino Acids; Arginine; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Cells, Cultured; Glutamic Acid; Humans; Lysine; Membrane Proteins; Microscopy, Confocal; Multidrug Resistance-Associated Proteins; Mutation; Protein Structure, Secondary; Protein Structure, Tertiary; Substrate Specificity; Transfection | 2004 |
Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density.
Topics: 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Dizocilpine Maleate; Drug Interactions; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Models, Neurological; N-Methylaspartate; Neural Inhibition; Neurons; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Synapses | 2004 |
Structural effects of radiation damage and its potential for phasing.
Topics: Aspartic Acid; Crystallography, X-Ray; Glutamic Acid; Models, Molecular; Models, Statistical; Models, Theoretical; Plant Proteins; Protein Conformation; Radiation Effects; Sulfur; X-Ray Diffraction | 2004 |
Cannabinoid signaling in rat cerebellar granule cells: G-protein activation, inhibition of glutamate release and endogenous cannabinoids.
Topics: Animals; Arachidonic Acids; Aspartic Acid; Cannabinoids; Cells, Cultured; Cerebellum; Endocannabinoids; Female; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Membrane Potentials; Neurons; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Signal Transduction | 2004 |
Involvement of a Glu71-Arg64 couple in the access channel for NADH in cytochrome p450nor.
Topics: Amino Acid Substitution; Arginine; Aspartic Acid; Cytochrome P-450 Enzyme System; Fusarium; Glutamic Acid; Heme; Molecular Structure; NAD; Oxidoreductases; Point Mutation | 2004 |
Structural changes in glutamate cell swelling followed by multiparametric q-space diffusion MR of excised rat spinal cord.
Topics: Animals; Aspartic Acid; Biomarkers; Diffusion Magnetic Resonance Imaging; Edema; Extracellular Space; Glutamic Acid; Intracellular Space; Quaternary Ammonium Compounds; Rats; Sensitivity and Specificity; Spinal Cord | 2004 |
Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain.
Topics: Amino Acid Sequence; Animals; Antibodies; Aspartic Acid; Caveolae; Caveolin 1; Caveolins; Cell Membrane; COS Cells; Glutamic Acid; Golgi Apparatus; HeLa Cells; Humans; Molecular Sequence Data; Mutation; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport; src-Family Kinases | 2004 |
Functional roles of four conserved charged residues in the membrane domain subunit NuoA of the proton-translocating NADH-quinone oxidoreductase from Escherichia coli.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Blotting, Western; Cell Division; Cell Membrane; Cloning, Molecular; Cytoplasm; DNA; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Genetic Vectors; Glutamic Acid; Immunoblotting; Immunohistochemistry; Mice; Mice, Knockout; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport; Protons; Quinone Reductases; Sequence Homology, Amino Acid; Transgenes | 2004 |
Two cases of compound heterozygosity for Hb Hekinan [alpha27(B8)Glu-->Asp (alpha1)] and alpha-thalassemia in Thailand.
Topics: Adult; alpha-Thalassemia; Amino Acid Substitution; Aspartic Acid; Female; Genotype; Globins; Glutamic Acid; Hemoglobins, Abnormal; Heterozygote; Humans; Thailand | 2004 |
Identification of a novel protonation pattern for carboxylic acids upon Q(B) photoreduction in Rhodobacter sphaeroides reaction center mutants at Asp-L213 and Glu-L212 sites.
Topics: Amino Acid Substitution; Aspartic Acid; Benzoquinones; Carboxylic Acids; Glutamic Acid; Light; Molecular Structure; Mutation; Photosynthetic Reaction Center Complex Proteins; Protein Structure, Tertiary; Protons; Rhodobacter sphaeroides; Spectroscopy, Fourier Transform Infrared | 2004 |
A rare transthyretin mutation (Asp18Glu) associated with cardiomyopathy.
Topics: Amino Acid Substitution; Amyloidosis, Familial; Aspartic Acid; Cardiomyopathies; Exons; Glutamic Acid; Humans; Male; Mass Spectrometry; Middle Aged; Polymorphism, Restriction Fragment Length; Polymorphism, Single-Stranded Conformational; Prealbumin | 2004 |
Synthesis of carbamate-type caged derivatives of a novel glutamate transporter blocker.
Topics: Amination; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Carbamates; Cell Line; Dogs; Fluorine; Glutamic Acid; Methylation; Molecular Structure; Spectrum Analysis | 2004 |
Capillary electrophoresis combined with microdialysis in the human spinal cord: a new tool for monitoring rapid peroperative changes in amino acid neurotransmitters within the dorsal horn.
Topics: Aspartic Acid; Electrophoresis, Capillary; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Microdialysis; Naphthalenes; Posterior Horn Cells; Spinal Cord | 2004 |
Caspase-mediated specific cleavage of human histone deacetylase 4.
Topics: Amino Acid Motifs; Animals; Apoptosis; Aspartic Acid; Binding Sites; Biological Transport; Caspase 3; Caspases; Cell Death; Cell Differentiation; Cell Line, Tumor; Cell Survival; CHO Cells; Cricetinae; Cycloheximide; Cysteine Endopeptidases; Dactinomycin; Doxycycline; Genetic Vectors; Glutamic Acid; HeLa Cells; Histone Deacetylases; Humans; Models, Biological; Multienzyme Complexes; Mutagenesis, Site-Directed; Proline; Proteasome Endopeptidase Complex; Protein Binding; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Threonine; Time Factors; Ultraviolet Rays | 2004 |
Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Anions; Arginine; Aspartic Acid; Biological Transport; Catalysis; Cell Line, Transformed; Cytoplasm; DNA Mutational Analysis; DNA, Complementary; Glutamic Acid; Humans; Ions; Leukotriene C4; Models, Molecular; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Mutation; Organic Anion Transporters; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Time Factors; Transfection; Vanadates | 2004 |
The hydrogen bonds between Arg423 and Glu472 and other key residues, Asp443, Ser477, and Pro489, are responsible for the formation and a different positioning of TNP-ATP and ATP within the nucleotide-binding site of Na(+)/K(+)-ATPase.
Topics: Adenosine; Adenosine Triphosphate; Amino Acid Sequence; Amino Acids; Animals; Arginine; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes; Genetic Vectors; Glutamic Acid; Glutathione Transferase; Hydrogen; Hydrogen Bonding; Hydrolysis; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Nucleotides; Point Mutation; Proline; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Serine; Sodium-Potassium-Exchanging ATPase; Software; Spectrophotometry; Temperature | 2004 |
Retinal bipolar cell input mechanisms in giant danio. II. Patch-clamp analysis of on bipolar cells.
Topics: Aminobutyrates; Animals; Aspartic Acid; Barium; D-Aspartic Acid; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; In Vitro Techniques; Isoquinolines; Kainic Acid; Light; Membrane Potentials; Neurons; Patch-Clamp Techniques; Photic Stimulation; Potassium Channel Blockers; Receptors, Metabotropic Glutamate; Retina; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells; Tetraethylammonium; Time Factors; Visual Pathways; Zebrafish | 2005 |
5-HT control of ischemia-evoked glutamate efflux from human cerebrocortical slices.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Glucose; Glutamic Acid; Humans; Hypoxia, Brain; In Vitro Techniques; Male; Middle Aged; Reperfusion Injury; Serotonin; Serotonin Receptor Agonists | 2004 |
Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression.
Topics: Adult; Aspartic Acid; Choline; Depressive Disorder; Diagnostic and Statistical Manual of Mental Disorders; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Psychiatric Status Rating Scales; Severity of Illness Index | 2004 |
Substitution of aspartic acid with glutamic acid increases the unfolding transition temperature of a protein.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Bacterial Proteins; Computer Simulation; Euryarchaeota; Glutamic Acid; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Protein Denaturation; Protein Folding; Recombinant Proteins; Species Specificity; Structure-Activity Relationship; Thioredoxins; Transition Temperature | 2004 |
Localization and function of the brain excitatory amino acid transporter type 1 in cardiac mitochondria.
Topics: Adenoviridae; Animals; Aspartic Acid; Blotting, Northern; Brain; Cells, Cultured; Coloring Agents; Cytochromes c; Digitonin; DNA, Complementary; Excitatory Amino Acid Transporter 1; Genetic Vectors; Glutamic Acid; Hypoxia; Immunoblotting; Immunohistochemistry; Malates; Microscopy, Fluorescence; Mitochondria; Mitochondria, Heart; Myocardium; Open Reading Frames; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Subcellular Fractions; Tetrazolium Salts; Thiazoles; Transfection | 2004 |
Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K+ channels: implication for dimerization of nucleotide-binding domains to induce channel opening.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; ATP-Binding Cassette Transporters; Binding Sites; Dimerization; Glutamic Acid; Glutamine; Humans; Membrane Proteins; Mice; Mutation; Nicorandil; Nucleotides; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Structure, Tertiary; Receptors, Drug; Sodium; Sulfonylurea Receptors | 2004 |
Shape control of anatase TiO2 nanoparticles by amino acids in a gel-sol system.
Topics: Amino Acids; Aspartic Acid; Biocompatible Materials; Crystallization; Glutamic Acid; Microscopy, Electron, Transmission; Nanostructures; Titanium | 2004 |
Chemotactic response of Helicobacter pylori to human plasma and bile.
Topics: Adaptation, Physiological; Adult; Amino Acids; Arginine; Aspartic Acid; Bile; Bile Acids and Salts; Chemotactic Factors; Chemotaxis; Glutamic Acid; Glycine; Helicobacter pylori; Histidine; Humans; In Vitro Techniques; Male; Plasma; Taurocholic Acid; Taurodeoxycholic Acid; Urea | 2004 |
Kinetic studies of Thermobifida fusca Cel9A active site mutant enzymes.
Topics: Actinomycetales; Amino Acid Substitution; Arginine; Aspartic Acid; Bacterial Proteins; Binding Sites; Carboxymethylcellulose Sodium; Cellulase; Enzyme Activation; Fibronectins; Glutamic Acid; Kinetics; Leucine; Lysine; Protein Folding; Protein Structure, Tertiary; Recombinant Proteins; Sequence Deletion; Substrate Specificity; Threonine; Tyrosine | 2004 |
Acidic C-tail of HMGB1 is required for its target binding to nucleosome linker DNA and transcription stimulation.
Topics: Animals; Aspartic Acid; Binding, Competitive; Chlorocebus aethiops; COS Cells; DNA; Glutamic Acid; Histones; HMGB1 Protein; Hydrogen-Ion Concentration; Nucleosomes; Peptide Fragments; Protein Binding; Sequence Deletion; Transcriptional Activation; Transfection | 2004 |
Crystal structure of a high-affinity variant of rat alpha-parvalbumin.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Binding Sites; Calcium; Calcium-Binding Proteins; Cations, Divalent; Crystallization; Crystallography, X-Ray; EF Hand Motifs; Glutamic Acid; Magnesium; Parvalbumins; Potassium; Protein Binding; Protein Isoforms; Protein Structure, Secondary; Rats; Serine; Solutions | 2004 |
Bound peptide-dependent thermal stability of major histocompatibility complex class II molecule I-Ek.
Topics: Animals; Antigen Presentation; Aspartic Acid; Calorimetry, Differential Scanning; CD4-Positive T-Lymphocytes; Chromatography, Gel; Glutamic Acid; Hemoglobins; Histocompatibility Antigens Class II; Hydrogen-Ion Concentration; Mice; Mutagenesis, Site-Directed; Peptide Fragments; Protein Binding; Protein Conformation; Protein Denaturation; Thermodynamics | 2004 |
Biosynthesis of NAAG by an enzyme-mediated process in rat central nervous system neurons and glia.
Topics: Animals; Aspartic Acid; Cells, Cultured; Central Nervous System; Cerebellum; Cerebral Cortex; Culture Media, Serum-Free; Dipeptides; Enzymes; Glutamic Acid; Glutamine; Neuroglia; Neurons; Potassium Chloride; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Spinal Cord; Tritium | 2004 |
Krebs cycle enzymes from livers of old mice are differentially regulated by caloric restriction.
Topics: Aging; Animals; Aspartic Acid; Caloric Restriction; Citric Acid; Citric Acid Cycle; Glutamic Acid; Ketoglutaric Acids; Liver; Malates; Male; Mice; Mice, Inbred C57BL; Time Factors | 2004 |
Crystal structure of a family 54 alpha-L-arabinofuranosidase reveals a novel carbohydrate-binding module that can bind arabinose.
Topics: Amino Acid Motifs; Amino Acid Sequence; Arabinose; Aspartic Acid; Aspergillus; Binding Sites; Carbohydrates; Catalytic Domain; Cloning, Molecular; Crystallography, X-Ray; Cysteine; Disulfides; DNA Mutational Analysis; Electrons; Glutamic Acid; Glycoside Hydrolases; Kinetics; Models, Molecular; Molecular Sequence Data; Multigene Family; Mutagenesis, Site-Directed; Protein Binding; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid | 2004 |
Ischemia and reoxygenation induced amino acid release release and tissue damage in the slices of rat corpus striatum.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Calcium; Citrulline; Corpus Striatum; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hypoxia; Ions; Ischemia; L-Lactate Dehydrogenase; Male; Oxygen; Rats; Rats, Wistar; Reperfusion Injury; Taurine; Tetrodotoxin; Time Factors | 2004 |
Interaction of aluminium ions with some amino acids present in human blood.
Topics: Aluminum; Amino Acids; Aspartic Acid; Chromatography; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Copper; Filtration; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Ions; Ligands; Lysine; Metals; o-Phthalaldehyde; Ornithine; Spectrophotometry, Atomic; Tyrosine | 2004 |
The effect of sugar, amino acid, metal ion, and NaCl on model Maillard reaction under pH control.
Topics: Alanine; Amino Acids; Arabinose; Arginine; Aspartic Acid; Biochemistry; Carbohydrates; Colorimetry; Copper; Cysteine; Fructose; Glucose; Glutamic Acid; Glycine max; Hot Temperature; Hydrogen-Ion Concentration; Ions; Iron; Isoleucine; Leucine; Lysine; Maltose; Metals; Models, Chemical; Phenylalanine; Proline; Serine; Sodium Chloride; Temperature; Time Factors; Valine; Xylose | 2004 |
Analysis and prediction of leucine-rich nuclear export signals.
Topics: Active Transport, Cell Nucleus; Algorithms; Artificial Intelligence; Aspartic Acid; Computational Biology; Computing Methodologies; Consensus Sequence; Databases, Protein; Glutamic Acid; Hydrophobic and Hydrophilic Interactions; Internet; Isoelectric Point; Leucine; Markov Chains; Models, Molecular; Neural Networks, Computer; Nuclear Proteins; Protein Sorting Signals; Protein Structure, Secondary; Protein Structure, Tertiary; Reproducibility of Results; ROC Curve; Sequence Alignment; Serine; Structural Homology, Protein | 2004 |
Dissociation of [3H]L-glutamate uptake from L-glutamate-induced [3H]D-aspartate release by 3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid and 3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid, two con
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Carboxylic Acids; Cells, Cultured; Glutamic Acid; Ions; Male; Oxazoles; Rats; Synaptosomes; Tritium | 2004 |
Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls.
Topics: Adolescent; Aspartic Acid; Child; Choline; Creatine; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Obsessive-Compulsive Disorder; Personality Assessment; Phosphocreatine; Reference Values; Synaptic Transmission | 2004 |
Properties of P-glycoprotein with mutations in the "catalytic carboxylate" glutamate residues.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Alanine; Animals; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Carboxylic Acids; Catalysis; Dimerization; Dithiothreitol; Dose-Response Relationship, Drug; Glutamic Acid; Hydrolysis; Kinetics; Lipid Metabolism; Lysine; Mice; Models, Chemical; Mutation; Pichia; Protein Conformation; Protein Structure, Tertiary; Time Factors; Vanadates | 2004 |
Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase.
Topics: Adenine; Aspartic Acid; Binding Sites; Catalysis; Catalytic Domain; Crystallography, X-Ray; DNA; DNA Glycosylases; Dose-Response Relationship, Drug; Escherichia coli; Glutamic Acid; Guanine; Kinetics; Lysine; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Time Factors | 2004 |
Follow-up of nemaline myopathy in two patients with novel mutations in the skeletal muscle alpha-actin gene (ACTA1).
Topics: Actins; Aspartic Acid; DNA Mutational Analysis; Exons; Female; Follow-Up Studies; Genetic Carrier Screening; Glutamic Acid; Glycine; Heterozygote; Humans; Lysine; Male; Microscopy, Electron; Muscle, Skeletal; Mutation; Myopathies, Nemaline | 2004 |
High-resolution magic angle spinning and 1H magnetic resonance spectroscopy reveal significantly altered neuronal metabolite profiles in CLN1 but not in CLN3.
Topics: Adolescent; Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Chemistry; Child; Child, Preschool; Choline; Creatine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Membrane Glycoproteins; Membrane Proteins; Molecular Chaperones; Neuronal Ceroid-Lipofuscinoses; Neurons; Thiolester Hydrolases | 2004 |
Acute effects of 17beta-estradiol on the extracellular concentration of excitatory amino acids and energy metabolites during transient cerebral ischemia in male rats.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain Infarction; Chromatography, High Pressure Liquid; Disease Models, Animal; Electrochemistry; Energy Metabolism; Estradiol; Excitatory Amino Acids; Extracellular Space; Glucose; Glutamic Acid; Ischemic Attack, Transient; Male; Microdialysis; Rats; Rats, Wistar; Reperfusion; Time Factors | 2004 |
[The effect of glutamate and aspartate on myocardial protection at cardiopulmonary bypass].
Topics: Aspartic Acid; Coronary Artery Bypass; Glutamic Acid; Humans; Myocardial Reperfusion Injury | 2004 |
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
Coordination of divalent metal ions in the active site of poly(A)-specific ribonuclease.
Topics: Adenosine; Aspartic Acid; Binding Sites; Cadmium; Cobalt; Conserved Sequence; Exoribonucleases; Glutamic Acid; Humans; Hydrolysis; Ions; Kinetics; Magnesium; Manganese; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Oxygen; Protein Binding; Recombinant Proteins; RNA; RNA, Messenger; Stereoisomerism; Substrate Specificity; Zinc | 2004 |
Neurotransmitter amino acid in cerebrospinal fluid of patients with dementia with Lewy bodies.
Topics: Age Factors; Age of Onset; Aged; Asparagine; Aspartic Acid; Body Mass Index; Brain; Cerebrospinal Fluid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Lewy Body Disease; Male; Neuropsychological Tests; Neurotransmitter Agents | 2005 |
Glutamate transport by retinal Muller cells in glutamate/aspartate transporter-knockout mice.
Topics: Amino Acid Transport System ASC; Amino Acid Transport System X-AG; Amino Acid Transport Systems; Animals; Aspartic Acid; Biological Transport; Cells, Cultured; Excitatory Amino Acid Transporter 1; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neuroglia; Patch-Clamp Techniques; Retina; Sodium; Sodium Channels; Symporters; Up-Regulation | 2005 |
Negatively charged residues and hydrogen bonds tune the ligand histidine pKa values of Rieske iron-sulfur proteins.
Topics: Animals; Aspartic Acid; Burkholderia; Cattle; Computer Simulation; Electron Transport Complex III; Ferredoxins; Glutamic Acid; Glutamine; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Iron-Sulfur Proteins; Ligands; Models, Chemical; Mutagenesis, Site-Directed; Rhodobacter sphaeroides; Static Electricity; Thermodynamics; Titrimetry | 2004 |
Time-resolved photointermediate changes in rhodopsin glutamic acid 181 mutants.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Cattle; COS Cells; Glutamic Acid; Glutamine; Mutagenesis, Site-Directed; Phenylalanine; Photolysis; Protons; Rhodopsin; Schiff Bases; Spectrophotometry | 2004 |
Aspartate release from rat hippocampal synaptosomes.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Aspartic Acid; Blotting, Western; Botulinum Toxins; Calcium; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hippocampus; Ionomycin; Ionophores; Metalloendopeptidases; Niflumic Acid; Potassium; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Spider Venoms; Synaptosomes; Tetanus Toxin; Thiourea | 2004 |
Two novel mutant human adenylosuccinate lyases (ASLs) associated with autism and characterization of the equivalent mutant Bacillus subtilis ASL.
Topics: Adenosine Monophosphate; Adenylosuccinate Lyase; Amino Acid Sequence; Arginine; Aspartic Acid; Autistic Disorder; Bacillus subtilis; Circular Dichroism; DNA; Electrophoresis, Polyacrylamide Gel; Family Health; Female; Glutamic Acid; Heterozygote; Hot Temperature; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mothers; Mutagenesis, Site-Directed; Mutation; Polymerase Chain Reaction; Protein Binding; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Spectrophotometry; Temperature; Thermotoga maritima; Time Factors; Ultraviolet Rays | 2004 |
Enhanced release of synaptic glutamate underlies the potentiation of oxygen-glucose deprivation-induced neuronal injury after induction of NOS-2.
Topics: Animals; Aspartic Acid; Cell Death; Cell Hypoxia; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Induction; Extracellular Space; Glucose; Glutamic Acid; Hypoxia-Ischemia, Brain; Mice; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrobenzoates; Riluzole; Synapses; Tetanus Toxin | 2004 |
Mutational analysis of the nuclease domain of Escherichia coli ribonuclease III. Identification of conserved acidic residues that are important for catalytic function in vitro.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Base Sequence; Catalysis; Catalytic Domain; Conserved Sequence; DNA Mutational Analysis; DNA, Bacterial; Escherichia coli Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Hydrolysis; Manganese; Molecular Sequence Data; Protein Subunits; Ribonuclease III; Sequence Alignment; Sequence Homology, Amino Acid | 2004 |
Mechanistic insights from the structures of HincII bound to cognate DNA cleaved from addition of Mg2+ and Mn2+.
Topics: Aspartic Acid; Bacteria; Crystallography, X-Ray; Deoxyribonucleases, Type II Site-Specific; DNA; Glutamic Acid; Magnesium; Manganese; Phosphates; Protein Structure, Tertiary | 2004 |
Plasmin(ogen)-binding alpha-enolase from Streptococcus pneumoniae: crystal structure and evaluation of plasmin(ogen)-binding sites.
Topics: Aspartic Acid; Glutamic Acid; Magnesium; Phosphopyruvate Hydratase; Plasminogen; Protein Structure, Quaternary; Protein Structure, Tertiary; Streptococcus pneumoniae | 2004 |
Differential control of synaptic and ectopic vesicular release of glutamate.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Calcium Channels; Cerebellum; Excitatory Postsynaptic Potentials; Exocytosis; Glutamic Acid; In Vitro Techniques; Neuroglia; Neuronal Plasticity; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, AMPA; Synapses; Synaptic Transmission; Synaptic Vesicles; Time Factors | 2004 |
Nitric oxide-induced increase of excitatory amino acid levels in the trigeminal nucleus caudalis of the rat with tactile hypersensitivity evoked by the loose-ligation of the inferior alveolar nerves.
Topics: Animals; Aspartic Acid; Benzoates; Capsaicin; Dental Pulp; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acids; Glutamic Acid; Hyperalgesia; Imidazoles; Injections, Subcutaneous; Ligation; Lip; Male; Mandibular Nerve; Microdialysis; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Trigeminal Nuclei | 2004 |
Cephalopod vision involves dicarboxylic amino acids: D-aspartate, L-aspartate and L-glutamate.
Topics: Amino Acid Isomerases; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Biological Transport, Active; Cattle; D-Aspartic Acid; Darkness; Decapodiformes; Glutamic Acid; Kidney; Light; Mollusca; Neurosecretory Systems; Octopodiformes; Optic Lobe, Nonmammalian; Retina; Tritium; Vision, Ocular | 2005 |
Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Amino Acids; Animals; Aspartic Acid; Dicarboxylic Acids; Drug Interactions; Entorhinal Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission; Xanthenes | 2004 |
The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells.
Topics: Adenosine Triphosphate; Adenoviridae; Animals; Aspartic Acid; Calcium; Cell Line; Cell Separation; Cells, Cultured; Cytosol; Epitopes; Flow Cytometry; Glucose; Glutamic Acid; Glycolysis; Humans; Immunoblotting; Insulin; Insulin Secretion; Islets of Langerhans; Lac Operon; Lactates; Malates; Membrane Potentials; Membrane Transport Proteins; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Models, Biological; NADP; Oxygen; Protein Isoforms; Rats; Tissue Distribution | 2004 |
[Changes of amino acid content in hippocampus of epileptic rats treated with volatile oil of Acorus tatarinowii].
Topics: Acorus; Animals; Anticonvulsants; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; Male; Oils, Volatile; Plants, Medicinal; Rats; Rats, Sprague-Dawley | 2004 |
A substrate-phage approach for investigating caspase specificity.
Topics: Amino Acid Motifs; Apoptosis; Aspartic Acid; Biochemistry; Caspase 3; Caspase 8; Caspases; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Peptide Library; Peptides; Protein Binding; Substrate Specificity; Time Factors | 2004 |
Glutamate efflux from human cerebrocortical slices during ischemia: vesicular-like mode of glutamate release and sensitivity to A(2A) adenosine receptor blockade.
Topics: Adenosine A2 Receptor Antagonists; Adult; Aged; Anesthetics, Local; Aspartic Acid; Brain Ischemia; Calcium; Cerebral Cortex; Female; Glucose; Glutamic Acid; Humans; In Vitro Techniques; Male; Middle Aged; Neuroprotective Agents; Pyrimidines; Reperfusion Injury; Synaptic Vesicles; Tetrodotoxin; Triazoles | 2004 |
Role of lysine-256 in Citrobacter freundii tyrosine phenol-lyase in monovalent cation activation.
Topics: Alanine; Animals; Arginine; Aspartic Acid; Cations, Monovalent; Citrobacter freundii; Enzyme Activation; Glutamic Acid; Histidine; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Potassium; Protein Binding; Pyridoxal Phosphate; Rabbits; Spectrophotometry; Tyrosine Phenol-Lyase | 2004 |
Effects of acute and chronic lamotrigine treatment on basal and stimulated extracellular amino acids in the hippocampus of freely moving rats.
Topics: Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain Chemistry; Dose-Response Relationship, Drug; Drug Administration Schedule; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Lamotrigine; Male; Microdialysis; Potassium Chloride; Rats; Rats, Wistar; Taurine; Triazines; Veratridine | 2004 |
Glutamate-evoked alterations of glial and neuronal cell morphology in the guinea pig retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Cell Size; Circadian Rhythm; Cytochalasin D; Cytoskeleton; Dicarboxylic Acids; Dopamine; Eye Proteins; Glutamic Acid; Guinea Pigs; Ischemia; Kainic Acid; N-Methylaspartate; Neuroglia; Neurons; Nocodazole; Potassium; Pyrrolidines; Receptors, AMPA; Receptors, Kainic Acid; Retina; Retinal Ganglion Cells; Synaptic Transmission; Xanthenes | 2004 |
Cerebrospinal fluid excitatory amino acids and tau protein in children with acute lymphoblastic leukemia treated according to the BFM protocol.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Aspartic Acid; Child; Daunorubicin; Excitatory Amino Acids; Glutamic Acid; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; tau Proteins; Vincristine | 2004 |
Effects of glutamate transport substrates and glutamate receptor ligands on the activity of Na-/K(+)-ATPase in brain tissue in vitro.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Brain; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; In Vitro Techniques; Ionophores; Ligands; Male; Microscopy, Electron; Neurotoxins; Ouabain; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Rubidium; Sodium-Potassium-Exchanging ATPase; Spectrophotometry, Atomic; Synaptic Transmission | 2004 |
Hydrogen peroxide potentiates volume-sensitive excitatory amino acid release via a mechanism involving Ca2+/calmodulin-dependent protein kinase II.
Topics: Amino Acids; Animals; Anions; Aspartic Acid; Astrocytes; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Glutamic Acid; Hydrogen Peroxide; Ion Channels; Oxidants; Rats; Rats, Sprague-Dawley; Signal Transduction; Tritium | 2005 |
Further studies on the fragmentation of protonated ions of peptides containing aspartic acid, glutamic acid, cysteine sulfinic acid, and cysteine sulfonic acid.
Topics: Amino Acid Sequence; Aspartic Acid; Cysteine; Glutamic Acid; Oligopeptides; Peptides; Spectrometry, Mass, Electrospray Ionization; Sulfonic Acids | 2005 |
Saccharomyces cerevisiae Aqr1 is an internal-membrane transporter involved in excretion of amino acids.
Topics: Alanine; Amino Acids; Aspartic Acid; beta-Galactosidase; Biological Transport; Cell Membrane; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endocytosis; Exocytosis; Gene Expression Regulation, Fungal; Genotype; Glutamic Acid; Green Fluorescent Proteins; Homoserine; Membrane Transport Proteins; Methylamines; Microscopy, Fluorescence; Models, Biological; Monocarboxylic Acid Transporters; Mutation; Oligonucleotides; Plasmids; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Threonine; Time Factors | 2004 |
Neuroglial metabolism in the awake rat brain: CO2 fixation increases with brain activity.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain; Carbon Dioxide; Carbon Isotopes; Carbon Radioisotopes; Energy Metabolism; Glucose; Glutamic Acid; Glutamine; Male; Models, Biological; Neuroglia; Neurons; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Wakefulness | 2004 |
Gln-tRNAGln formation from Glu-tRNAGln requires cooperation of an asparaginase and a Glu-tRNAGln kinase.
Topics: Adenosine Triphosphate; Ammonium Chloride; Archaea; Asparaginase; Aspartic Acid; Binding Sites; Chromatography, Thin Layer; Cloning, Molecular; Enzyme Activation; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Hydrolysis; Lysine; Methanobacteriaceae; Models, Chemical; Mutation; Phosphorylation; Protein Biosynthesis; Protein Kinases; Pyrrolidonecarboxylic Acid; RNA, Transfer; RNA, Transfer, Gln; Threonine | 2005 |
N-terminal sequence of a core protein from a biglycan isolated from bovine aorta.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Aorta; Aspartic Acid; Biglycan; Cartilage, Articular; Cattle; Chondroitin ABC Lyase; Connective Tissue; Glutamic Acid; Glycosaminoglycans; Leucine; Molecular Weight; Muscle Proteins; Myocytes, Smooth Muscle; Protein Structure, Tertiary; Proteoglycans; Sequence Homology, Amino Acid; Species Specificity | 1995 |
Heterogeneity in 1H-MRS profiles of presymptomatic and early manifest Huntington's disease.
Topics: Adult; Age of Onset; Aged; Aspartic Acid; Early Diagnosis; Female; Glutamic Acid; Glutamine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Putamen | 2005 |
1H Magnetic resonance spectroscopy of the internal capsule in human brain: a feasibility study to detect lactate following contralateral motor activity.
Topics: Adenosine Triphosphate; Adult; Aspartic Acid; Astrocytes; Axons; Choline; Creatine; Energy Metabolism; Feasibility Studies; Female; Glutamic Acid; Glycogen; Hand Strength; Humans; Hydrogen; Inositol; Internal Capsule; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Motor Activity | 2005 |
Changes in intracellular cyclic AMP formation mask opposing modulation of kainate-enhanced glutamate release in the striatum.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenylyl Cyclase Inhibitors; Adrenergic beta-Agonists; Alloxan; Animals; Aspartic Acid; Cyclic AMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; Isoproterenol; Kainic Acid; Kinetics; Mice; Neostriatum; Phenethylamines | 2004 |
Mercury compounds disrupt neuronal glutamate transport in cultured mouse cerebellar granule cells.
Topics: Adenosine Triphosphate; Amino Acid Transport System X-AG; Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Aspartic Acid; Blotting, Western; Cell Death; Cells, Cultured; Cerebellum; Chlorides; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Excitatory Amino Acid Transporter 3; Gene Expression Regulation; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Mercury Compounds; Mice; Neurons; Phosphines; Symporters; Tritium | 2005 |
Microdialysis of the lateral and medial temporal lobe during temporal lobe epilepsy surgery.
Topics: Action Potentials; Adult; Aspartic Acid; Electroencephalography; Epilepsy, Temporal Lobe; Extracellular Fluid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; Male; Microdialysis; Neocortex; Neurosurgical Procedures; Neurotransmitter Agents; Temporal Lobe | 2005 |
Identification of single Mn(2+) binding sites required for activation of the mutant proteins of E.coli RNase HI at Glu48 and/or Asp134 by X-ray crystallography.
Topics: Aspartic Acid; Binding Sites; Crystallography, X-Ray; Enzyme Activation; Escherichia coli; Glutamic Acid; Manganese; Models, Molecular; Mutation; Protein Structure, Tertiary; Ribonuclease H | 2005 |
White-matter disease in 18q deletion (18q-) syndrome: magnetic resonance spectroscopy indicates demyelination or increased myelin turnover rather than dysmyelination.
Topics: Aspartic Acid; Brain Diseases; Choline; Chromosome Deletion; Chromosomes, Human, Pair 18; Demyelinating Diseases; Female; Follow-Up Studies; Glutamic Acid; Humans; Infant; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Myelin Sheath | 2005 |
Effect of LTP-reinforcing paradigms on neurotransmitter release in the dentate gyrus of young and aged rats.
Topics: Acetylcholine; Aging; Animals; Aspartic Acid; Choline; Dentate Gyrus; Glutamic Acid; Glycine; Hydroxyindoleacetic Acid; Long-Term Potentiation; Microdialysis; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Sprague-Dawley; Serotonin; Synaptic Transmission | 2005 |
Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Disease Models, Animal; Disease Progression; Energy Metabolism; Female; Frontal Lobe; Glutamic Acid; Magnetic Resonance Imaging; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Plaque, Amyloid; Presenilin-2; Spectrum Analysis | 2005 |
Evidence for glutamatergic neuronal dysfunction in the prefrontal cortex in chronic but not in first-episode patients with schizophrenia: a proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Chronic Disease; Diagnostic and Statistical Manual of Mental Disorders; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Neurons; Prefrontal Cortex; Protons; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index; Synaptic Transmission | 2005 |
A vibrational spectral maker for probing the hydrogen-bonding status of protonated Asp and Glu residues.
Topics: Aspartic Acid; Bacterial Proteins; Biophysics; Carbon; Crystallography, X-Ray; Glutamic Acid; Hydrogen; Hydrogen Bonding; Models, Molecular; Oxygen; Photoreceptors, Microbial; Protein Conformation; Protons; Spectrophotometry; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Thermodynamics; Vibration | 2005 |
Excitotoxic death induced by released glutamate in depolarized primary cultures of mouse cerebellar granule cells is dependent on GABAA receptors and niflumic acid-sensitive chloride channels.
Topics: Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Chloride Channels; Chlorides; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Immunohistochemistry; Mice; Naphthalenes; Neurons; Neurotoxins; Niflumic Acid; Oxepins; Potassium Chloride; Propidium; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Riluzole; Tritium | 2005 |
Chemical shift magnetic resonance spectroscopy of cingulate grey matter in patients with minimal hepatic encephalopathy.
Topics: Aspartic Acid; Cerebral Cortex; Choline; Creatinine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Hepatic Encephalopathy; Humans; Inositol; Intelligence Tests; Liver Cirrhosis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memory; Memory, Short-Term; Mental Recall; Middle Aged; Neuropsychological Tests; Psychomotor Performance; Trail Making Test | 2005 |
Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway.
Topics: Alanine; Amidohydrolases; Asparagine; Aspartic Acid; Bacterial Proteins; Glutamic Acid; Gram-Negative Bacteria; Histidine; Hydrogen-Ion Concentration; Kinetics; Lipid A; Lysine; Mutagenesis, Site-Directed; Substrate Specificity; Zinc | 2005 |
Hyperresponsiveness on washout of volatile anesthetics from isolated spinal cord compared to withdrawal from ethanol.
Topics: Anesthetics, Inhalation; Animals; Aspartic Acid; Bronchial Hyperreactivity; Calcitonin Gene-Related Peptide; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Electric Stimulation; Enzyme Inhibitors; Ethanol; Excitatory Postsynaptic Potentials; Glutamic Acid; Indoles; Maleimides; Protein Kinase C; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Substance Withdrawal Syndrome | 2005 |
Proton pathways in green fluorescence protein.
Topics: Animals; Aspartic Acid; Binding Sites; Biophysics; Crystallography, X-Ray; Cytoplasm; Databases, Protein; Glutamic Acid; Glutamine; Green Fluorescent Proteins; Hydrogen-Ion Concentration; Light; Lysine; Models, Chemical; Models, Molecular; Mutation; Nitrogen; Point Mutation; Protein Conformation; Protons; Scyphozoa; Solvents; Spectrophotometry; Threonine; Time Factors; Tyrosine; Water; X-Rays | 2005 |
Electrostatic interactions involving lysine make major contributions to collagen triple-helix stability.
Topics: Amino Acid Motifs; Arginine; Aspartic Acid; Collagen; Computer Simulation; Glutamic Acid; Hydrophobic and Hydrophilic Interactions; Lysine; Models, Molecular; Peptide Fragments; Protein Structure, Secondary; Sequence Analysis, Protein; Static Electricity; Thermodynamics | 2005 |
Active site rearrangement of the 2-hydrazinopyridine adduct in Escherichia coli amine oxidase to an azo copper(II) chelate form: a key role for tyrosine 369 in controlling the mobility of the TPQ-2HP adduct.
Topics: Amine Oxidase (Copper-Containing); Asparagine; Aspartic Acid; Azo Compounds; Binding Sites; Cations, Divalent; Chelating Agents; Cobalt; Copper; Crystallography, X-Ray; Enzyme Inhibitors; Enzyme Stability; Escherichia coli Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Phenylalanine; Pyridones; Resorcinols; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Tyrosine | 2005 |
[Detection of amino acid neurotransmitters in cerebrospinal fluid of patients in persistent vegetative state].
Topics: Adolescent; Adult; Alanine; Aspartic Acid; Brain Injuries; Child; Female; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Persistent Vegetative State | 2005 |
Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury.
Topics: Adolescent; Age Factors; Aspartic Acid; Brain; Brain Injuries; Child; Child, Preschool; Choline; Coma; Disease Progression; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Nerve Degeneration; Occipital Lobe; Parietal Lobe; Predictive Value of Tests; Recovery of Function; Up-Regulation | 2004 |
Proton MRS in acute traumatic brain injury: role for glutamate/glutamine and choline for outcome prediction.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Injuries; Cerebral Cortex; Choline; Creatinine; Evoked Potentials, Somatosensory; Female; Follow-Up Studies; Glasgow Outcome Scale; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Time Factors | 2004 |
Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: enhancing the promiscuous D-arabino-hex-3-ulose 6-phosphate synthase reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase.
Topics: Alanine; Aldehyde-Lyases; Aldehydes; Amino Acid Substitution; Arginine; Aspartic Acid; Carboxy-Lyases; Catalysis; Decarboxylation; Enzyme Stability; Escherichia coli Proteins; Evolution, Molecular; Formaldehyde; Glutamic Acid; Histidine; Ketoses; Methylomonas; Orotidine-5'-Phosphate Decarboxylase; Ribulosephosphates; Stereoisomerism; Threonine; Valine | 2005 |
Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: structural basis for catalytic promiscuity in wild-type and designed mutants of 3-keto-L-gulonate 6-phosphate decarboxylase.
Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Binding Sites; Carboxy-Lyases; Catalysis; Crystallography, X-Ray; Enzyme Activation; Escherichia coli Proteins; Evolution, Molecular; Glutamic Acid; Mutagenesis, Site-Directed; Orotidine-5'-Phosphate Decarboxylase; Ribulosephosphates; Substrate Specificity; Threonine | 2005 |
Synthesis of 10- and 9-membered dilactams derived from aspartic and glutamic acids.
Topics: Aspartic Acid; Bridged-Ring Compounds; Dipeptides; Glutamic Acid; Lactams | 2005 |
High-field localized 1H NMR spectroscopy in the anesthetized and in the awake monkey.
Topics: Anesthesia, General; Animals; Artifacts; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Dipeptides; Glutamic Acid; Glutamine; Glutathione; Hydrogen; Image Enhancement; Inositol; Lactic Acid; Macaca mulatta; Magnetic Resonance Spectroscopy; Phosphocreatine; Stereoisomerism; Taurine; Wakefulness | 2004 |
In vivo quantitative 1H MRS of cerebellum and evaluation of quantitation reproducibility by simulation of different levels of noise and spectral resolution.
Topics: Adult; Artifacts; Aspartic Acid; Body Water; Cerebellum; Choline; Creatine; Dipeptides; Female; Glutamic Acid; Glutamine; Humans; Hydrogen; Image Enhancement; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Spectroscopy; Male; Neuropeptides | 2004 |
Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T.
Topics: Adult; Aged; Aging; Analysis of Variance; Aspartic Acid; Brain Chemistry; Creatine; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Protons; Statistics as Topic | 2005 |
Role of a conserved glutamate residue in the Escherichia coli SecA ATPase mechanism.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; Aspartic Acid; Bacillus subtilis; Bacterial Proteins; Binding Sites; Catalysis; Cell Membrane; Dimerization; Escherichia coli; Glutamic Acid; Hydrolysis; Kinetics; Magnesium; Membrane Transport Proteins; Molecular Sequence Data; Mutation; Phosphates; Protein Structure, Tertiary; Protein Transport; SEC Translocation Channels; SecA Proteins; Sequence Homology, Amino Acid; Time Factors | 2005 |
Detection of changes in taste of japonica and indica brown and milled rice (Oryza sativa L.) during storage using physicochemical analyses and a taste sensing system.
Topics: Aspartic Acid; Chemical Phenomena; Chemistry, Physical; Food Handling; Food Preservation; Glutamic Acid; Hot Temperature; Hydrogen-Ion Concentration; Oryza; Sensation; Sucrose; Taste; Time Factors | 2005 |
Familial hemiplegic migraine: more than just a headache.
Topics: Animals; Aspartic Acid; Brain Chemistry; Calcium Channels; Cerebellum; Genetic Heterogeneity; Glutamic Acid; Hemiplegia; Humans; Magnetic Resonance Spectroscopy; Mice; Migraine with Aura; Mutation; Parietal Lobe; Visual Cortex | 2005 |
1H-MRS alterations in the cerebellum of patients with familial hemiplegic migraine type 1.
Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Calcium Channels; Cerebellum; Choline; Creatine; Dysarthria; Essential Tremor; Female; Gait Ataxia; Glutamic Acid; Hemiplegia; Humans; Inositol; Lactates; Magnetic Resonance Spectroscopy; Male; Middle Aged; Migraine with Aura; Mutation; Parietal Lobe; Visual Cortex | 2005 |
Ser475, Glu272, Asp276, Asp327, and Asp360 are involved in catalytic activity of human tripeptidyl-peptidase I.
Topics: Amino Acid Sequence; Aminopeptidases; Animals; Aspartic Acid; Catalysis; CHO Cells; Cricetinae; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Glutamic Acid; Humans; Kinetics; Molecular Sequence Data; Mutation; Sequence Alignment; Serine; Serine Proteases; Tripeptidyl-Peptidase 1 | 2005 |
Metal-induced structural organization and stabilization of the metalloregulatory protein MntR.
Topics: Anilino Naphthalenesulfonates; Arginine; Aspartic Acid; Bacillus subtilis; Bacterial Proteins; Binding Sites; Circular Dichroism; DNA-Binding Proteins; Fluorescent Dyes; Glutamic Acid; Hot Temperature; Manganese; Metals, Heavy; Methionine; Protein Conformation; Protein Denaturation; Repressor Proteins | 2005 |
T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart study.
Topics: Aged; Albuminuria; Aspartic Acid; Creatinine; Cysteine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Exons; Female; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Homozygote; Humans; Linkage Disequilibrium; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Odds Ratio; Polymorphism, Genetic; Promoter Regions, Genetic; Threonine | 2005 |
Hinge residue Ile260 of DNA polymerase beta is important for enzyme activity and fidelity.
Topics: Amino Acid Substitution; Animals; Arginine; Asparagine; Aspartic Acid; DNA Polymerase beta; Enzyme Activation; Enzyme Stability; Escherichia coli Proteins; Genetic Complementation Test; Genetic Variation; Glutamic Acid; Glutamine; Histidine; Isoleucine; Lysine; Peptide Fragments; Phenotype; Protein Folding; Protein Structure, Tertiary; Rats; Substrate Specificity | 2005 |
The enlarging spectrum of desminopathies: new morphological findings, eastward geographic spread, novel exon 3 desmin mutation.
Topics: Adult; alpha-Crystallin B Chain; Aspartic Acid; Cardiomyopathy, Restrictive; Chromosomes, Human, Pair 2; Desmin; DNA Mutational Analysis; Exons; Family Health; Glutamic Acid; Humans; Immunohistochemistry; Male; Middle Aged; Muscle, Skeletal; Mutation; Myocardium; Staining and Labeling | 2005 |
Physiologic variability of single-voxel proton MR spectroscopic measurements at 3T.
Topics: Adult; Aspartic Acid; Brain; Calibration; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Models, Biological; Osmolar Concentration; Phantoms, Imaging; Reference Values; Reproducibility of Results; Temporal Lobe; Time Factors | 2005 |
Mechanism of the Schiff base forming fructose-1,6-bisphosphate aldolase: structural analysis of reaction intermediates.
Topics: Archaeal Proteins; Aspartic Acid; Binding Sites; Catalysis; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Fructose-Bisphosphate Aldolase; Glutamic Acid; Models, Molecular; Mutagenesis, Site-Directed; Phenylalanine; Schiff Bases; Structure-Activity Relationship; Substrate Specificity; Thermoproteus; Tyrosine | 2005 |
Regulation of extracellular glutamate in the prefrontal cortex: focus on the cystine glutamate exchanger and group I metabotropic glutamate receptors.
Topics: Animals; Aspartic Acid; Extracellular Space; Glutamic Acid; Immunoblotting; Immunohistochemistry; Male; Methoxyhydroxyphenylglycol; Microdialysis; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synapses | 2005 |
Factors governing the substitution of La3+ for Ca2+ and Mg2+ in metalloproteins: a DFT/CDM study.
Topics: Aspartic Acid; Binding Sites; Calcium; Cations; Glutamic Acid; Lanthanum; Magnesium; Metalloproteins; Models, Chemical; Models, Molecular; Thermodynamics | 2005 |
Deriving the glutamate clearance time course from transporter currents in CA1 hippocampal astrocytes: transmitter uptake gets faster during development.
Topics: Age Factors; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Sesterterpenes; Synapses; Time Factors | 2005 |
Detecting activity in olfactory bulb glomeruli with astrocyte recording.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Barium; Cadmium; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glial Fibrillary Acidic Protein; Glutamic Acid; Green Fluorescent Proteins; Immunohistochemistry; In Vitro Techniques; Membrane Potentials; Mice; Mice, Transgenic; Nerve Net; Olfactory Bulb; Olfactory Nerve; Olfactory Receptor Neurons; Patch-Clamp Techniques; Rats; Synapses | 2005 |
Leptin stimulates the reproductive male axis in rats during sexual maturation by acting on hypothalamic excitatory amino acids.
Topics: Amino Acids; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropin-Releasing Hormone; Hypothalamus; Leptin; Luteinizing Hormone; Male; Radioimmunoassay; Rats; Sexual Maturation | 2005 |
Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11.
Topics: Animals; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cholestasis, Intrahepatic; Dogs; Endoplasmic Reticulum; Glutamic Acid; Glycine; Glycosylation; Humans; Membranes; Mutation; Proteasome Endopeptidase Complex; Tissue Distribution | 2005 |
Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH.
Topics: Adenosine Triphosphate; Amino Acid Transport System X-AG; Ammonia; Animals; Aspartic Acid; Astrocytes; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Egtazic Acid; Endoplasmic Reticulum; Fluoresceins; Glutamic Acid; Hydrogen-Ion Concentration; Kainic Acid; Methylamines; Mice; Microscopy, Fluorescence; Spectrometry, Fluorescence; Thapsigargin; Ultraviolet Rays | 2005 |
Glutamate 636 of the Escherichia coli pyruvate dehydrogenase-E1 participates in active center communication and behaves as an engineered acetolactate synthase with unusual stereoselectivity.
Topics: Acetolactate Synthase; Aspartic Acid; Binding Sites; Catalysis; Circular Dichroism; Dose-Response Relationship, Drug; Escherichia coli; Genetic Variation; Glutamic Acid; Kinetics; Lactates; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Oxygen; Peptides; Plasmids; Protein Binding; Protein Structure, Tertiary; Pyrimidine Nucleosides; Pyruvate Dehydrogenase (Lipoamide); Spectrometry, Fluorescence; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Temperature; Thiamine Pyrophosphate; Trypsin; Ultraviolet Rays | 2005 |
Site-directed mutations (Asp405Ile and Glu124Ile) in cytochrome P450scc: effect on adrenodoxin binding.
Topics: Adrenodoxin; Aspartic Acid; Cholesterol Side-Chain Cleavage Enzyme; Electrochemistry; Glutamic Acid; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Spectrum Analysis | 2005 |
Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamic Acid; Male; Neurons, Afferent; Neurotransmitter Agents; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission | 2005 |
Single cell glutamate analysis in Aplysia sensory neurons.
Topics: Animals; Aplysia; Aspartic Acid; Ganglia, Invertebrate; Glutamic Acid; Immunologic Techniques; Mechanotransduction, Cellular; Neurons, Afferent; Oxazines; Tissue Distribution | 2005 |
Role of the covalent glutamic acid 242-heme linkage in the formation and reactivity of redox intermediates of human myeloperoxidase.
Topics: Animals; Aspartic Acid; Binding Sites; Bromides; Chlorides; CHO Cells; Circular Dichroism; Cricetinae; Cyanides; Enzyme Stability; Eosinophil Peroxidase; Ferric Compounds; Glutamic Acid; Glutamine; Heme; Humans; Methionine; Oxidation-Reduction; Peroxidase; Recombinant Proteins | 2005 |
Intrinsic isomerase activity of medium-chain acyl-CoA dehydrogenase.
Topics: Acyl Coenzyme A; Acyl-CoA Dehydrogenase; Animals; Aspartic Acid; Carbon-Carbon Double Bond Isomerases; Chromatography, High Pressure Liquid; Dodecenoyl-CoA Isomerase; Enzyme Activation; Enzyme Inhibitors; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Mitochondria, Liver; Mutagenesis, Site-Directed; Plasmids; Rats; Substrate Specificity; Thermodynamics | 2005 |
Are acidic and basic groups in buried proteins predicted to be ionized?
Topics: Amino Acids, Acidic; Amino Acids, Basic; Arginine; Aspartic Acid; Crystallography; Glutamic Acid; Ions; Lysine; Proteins; Static Electricity | 2005 |
1H chemical shift imaging of the brain in guanidino methyltransferase deficiency, a creatine deficiency syndrome; guanidinoacetate accumulation in the gray matter.
Topics: Aspartic Acid; Brain Chemistry; Child, Preschool; Choline; Creatine; Glutamic Acid; Glycine; Guanidinoacetate N-Methyltransferase; Humans; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Syndrome | 2005 |
Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
Topics: Animals; Aspartic Acid; Behavior, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Hormone Antagonists; In Vitro Techniques; Long-Term Synaptic Depression; Male; Mifepristone; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Stress, Physiological; Synaptosomes; Time Factors | 2005 |
8-hydroxy-2-(di-n-propylamino)tetralin reduces striatal glutamate in an animal model of Parkinson's disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Aspartic Acid; Corpus Striatum; Denervation; Disease Models, Animal; Glutamic Acid; Injections, Subcutaneous; Male; Microdialysis; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists; Sympatholytics | 2005 |
Probing the role of negatively charged amino acid residues in ion permeation of skeletal muscle ryanodine receptor.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Calcium; Cations; Cell Line; DNA, Complementary; Genetic Vectors; Glutamic Acid; Humans; Immunoblotting; Ions; Molecular Sequence Data; Muscle, Skeletal; Mutation; Oxygen; Potassium; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Rabbits; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sequence Homology, Amino Acid; Transfection | 2005 |
Point mutations at the type I Cu ligands, Cys457 and Met467, and at the putative proton donor, Asp105, in Myrothecium verrucaria bilirubin oxidase and reactions with dioxygen.
Topics: Alanine; Amino Acid Substitution; Asparagine; Aspartic Acid; Copper; Cysteine; Dithionite; Fungal Proteins; Glutamic Acid; Glutamine; Hypocreales; Ligands; Methionine; Oxidation-Reduction; Oxidoreductases Acting on CH-CH Group Donors; Oxygen; Point Mutation; Protons; Serine | 2005 |
Over-expression of the human EAAT2 glutamate transporter within neurons of mouse organotypic hippocampal slice cultures leads to increased vulnerability of CA1 pyramidal cells.
Topics: Amino Acid Transport System X-AG; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Blotting, Western; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Transporter 2; Gene Expression; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Humans; Kainic Acid; Mice; Neuroglia; Organ Culture Techniques; Phosphopyruvate Hydratase; Pyramidal Cells; Symporters; Time Factors; Transduction, Genetic; Tritium | 2005 |
Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal.
Topics: Alanine; Amino Acid Motifs; Animals; Aspartic Acid; Biophysics; Cell Line; DNA Mutational Analysis; DNA, Complementary; Dogs; Epithelial Cells; Glutamic Acid; Immunohistochemistry; Magnetic Resonance Spectroscopy; Models, Molecular; Peptides; Phenylalanine; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Receptor, Muscarinic M3; Recombinant Fusion Proteins; Signal Transduction; Temperature; Transfection | 2005 |
Endogenous activation of kainate receptors regulates glutamate release and network activity in the developing hippocampus.
Topics: Animals; Animals, Newborn; Aspartic Acid; Baclofen; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Furans; GABA Agonists; GABA Antagonists; Glutamic Acid; Guanosine Triphosphate; Hippocampus; In Vitro Techniques; Interneurons; Isoquinolines; Isoxazoles; Membrane Potentials; Mice; Mice, Knockout; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Picrotoxin; Probability; Receptors, Kainic Acid | 2005 |
Zero-length cross-linking reveals that tight interactions between the extracellular and transmembrane domains of the luteinizing hormone receptor persist during receptor activation.
Topics: Aspartic Acid; Binding Sites; Blotting, Western; Cell Membrane; Cell Separation; Cross-Linking Reagents; Cyclic AMP; Disulfides; Dose-Response Relationship, Drug; Flow Cytometry; Furin; Glutamic Acid; Humans; Immunoblotting; Lysine; Models, Biological; Protein Binding; Protein Structure, Tertiary; Receptors, LH; Recombinant Proteins; Time Factors; Transfection | 2005 |
Possible involvement of glutamic and/or aspartic acid residue(s) and requirement of mitochondrial integrity for the protective effect of creatine against inhibition of cardiac mitochondrial respiration by methylglyoxal.
Topics: Alamethicin; Animals; Aspartic Acid; Binding Sites; Cell Respiration; Creatine; Electron Transport Complex I; Glutamic Acid; Goats; Intracellular Membranes; Isoxazoles; Mitochondria, Heart; NAD; NADH Dehydrogenase; Oxygen Consumption; Permeability; Protective Agents; Pyruvaldehyde; Submitochondrial Particles | 2005 |
Response of brain amino acid metabolism to ketosis.
Topics: Acetates; Acetyl Coenzyme A; Amino Acids; Animals; Aspartate Aminotransferases; Aspartic Acid; Brain; Brain Chemistry; Carbon Radioisotopes; Energy Metabolism; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Ketosis; Male; Mice; Models, Animal; Oxaloacetic Acid | 2005 |
Ammonia effects on pyruvate/lactate production in astrocytes--interaction with glutamate.
Topics: Ammonia; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Bucladesine; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Energy Metabolism; Glutamic Acid; Glutamine; Glutathione; Glycolysis; Hyperammonemia; Interneurons; Lactic Acid; Malates; Mice; Mitochondria; Oxidation-Reduction; Oxidative Stress; Pyruvic Acid; Up-Regulation | 2005 |
Differential effects of the substrate inhibitor l-trans-pyrrolidine-2,4-dicarboxylate (PDC) and the non-substrate inhibitor DL-threo-beta-benzyloxyaspartate (DL-TBOA) of glutamate transporters on neuronal damage and extracellular amino acid levels in rat
Topics: Animals; Aspartic Acid; Behavior, Animal; Cell Death; Corpus Striatum; Dicarboxylic Acids; Electroencephalography; Extracellular Space; Glutamic Acid; Hippocampus; Injections, Intraventricular; Male; Microdialysis; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar | 2005 |
Changes in blood neurotransmitter and steroid levels during evoked vertigo.
Topics: Adult; Aspartic Acid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hydrocortisone; Male; Middle Aged; Nystagmus, Physiologic; Vertigo | 2005 |
Dexamethasone modulates the development of morphine tolerance and expression of glutamate transporters in rats.
Topics: Amino Acid Transport System X-AG; Analgesics, Opioid; Animals; Aspartic Acid; Dexamethasone; Drug Tolerance; Glucocorticoids; Glutamic Acid; Male; Morphine; Morphine Dependence; Nociceptors; Rats; Rats, Wistar; Spinal Cord | 2005 |
Observation of coupled 1H metabolite resonances at long TE.
Topics: Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Middle Aged; Phantoms, Imaging | 2005 |
Site-directed disulfide mapping of residues contributing to the Ca2+ and K+ binding pocket of the NCKX2 Na+/Ca2+-K+ exchanger.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Calcium; Cell Line; Cell Membrane; Cross-Linking Reagents; Cysteine; Disulfides; Glutamic Acid; Humans; Hydrolysis; Hydrophobic and Hydrophilic Interactions; Molecular Sequence Data; Mutagenesis, Insertional; Peptide Mapping; Phenanthrolines; Potassium; Protein Sorting Signals; Protein Structure, Secondary; Repetitive Sequences, Amino Acid; Serine; Sodium-Calcium Exchanger | 2005 |
Mutation analysis of COL9A3, a gene highly expressed in the cochlea, in hearing loss patients.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Cochlea; Collagen Type IX; DNA Mutational Analysis; Gene Deletion; Glutamic Acid; Glycine; Hearing Loss, Sensorineural; Humans; Molecular Sequence Data; Mutation; Mutation, Missense; Pedigree; Proline | 2005 |
Direct detection of brain acetylcholine synthesis by magnetic resonance spectroscopy.
Topics: Acetylcholine; Animals; Aspartic Acid; Betaine; Brain; Brain Chemistry; Glutamic Acid; In Vitro Techniques; Isotopes; Magnetic Resonance Spectroscopy; Male; Phosphorylcholine; Random Allocation; Rats | 2005 |
Role of glutamine and neuronal glutamate uptake in glutamate homeostasis and synthesis during vesicular release in cultured glutamatergic neurons.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Brain; Cells, Cultured; Citric Acid Cycle; Dicarboxylic Acids; Excitatory Postsynaptic Potentials; Glutamic Acid; Glutaminase; Glutamine; Homeostasis; Mice; Mitochondria; Neurons; Potassium; Presynaptic Terminals; Pyrrolidines; Synaptic Transmission; Synaptic Vesicles | 2005 |
Copper(II) complexes of oligopeptides containing aspartyl and glutamyl residues. Potentiometric and spectroscopic studies.
Topics: Aspartic Acid; Circular Dichroism; Copper; Electron Spin Resonance Spectroscopy; Glutamic Acid; Hydrogen-Ion Concentration; Ligands; Oligopeptides; Organometallic Compounds; Potentiometry; Spectrophotometry, Ultraviolet | 2005 |
Gliotoxicity in hippocampal cultures is induced by transportable, but not by nontransportable, glutamate uptake inhibitors.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Cell Death; Cells, Cultured; Dicarboxylic Acids; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Neuroglia; Neurons; Neurotoxins; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Receptors, N-Methyl-D-Aspartate; Valine | 2005 |
Staphylococcus aureus aminopeptidase S is a founding member of a new peptidase clan.
Topics: Aminopeptidases; Aspartic Acid; Binding Sites; Chromatography, Gel; Chromatography, Thin Layer; Cloning, Molecular; Cobalt; Crystallography, X-Ray; Dimerization; Glutamic Acid; Histidine; Ions; Ligands; Peptide Hydrolases; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Spectrophotometry, Atomic; Staphylococcus aureus; Temperature; Ultracentrifugation; Zinc | 2005 |
Binding of C5-dicarboxylic substrate to aspartate aminotransferase: implications for the conformational change at the transaldimination step.
Topics: Amines; Amino Acids, Dicarboxylic; Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Escherichia coli Proteins; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Imines; Ligands; Models, Chemical; N-Methylaspartate; Protein Conformation; Substrate Specificity | 2005 |
Single amino acid substitution in the putative transmembrane helix V in KdpB of the KdpFABC complex of Escherichia coli uncouples ATPase activity and ion transport.
Topics: Adenosine Triphosphatases; Alanine; Amino Acid Substitution; Aspartic Acid; Biological Transport, Active; Cation Transport Proteins; Cations, Monovalent; Enzyme Activation; Escherichia coli Proteins; Genetic Complementation Test; Glutamic Acid; Hydrolysis; Ion Channel Gating; Lysine; Membrane Proteins; Mutagenesis, Site-Directed; Potassium; Protein Structure, Secondary; Protein Subunits; Proteolipids; Vanadates | 2005 |
Titration of the bacteriorhodopsin Schiff base involves titration of an additional protein residue.
Topics: Amino Acid Substitution; Aspartic Acid; Bacteriorhodopsins; Deuterium Exchange Measurement; Glutamic Acid; Glutamine; Halobacterium salinarum; Hydrogen-Ion Concentration; Photochemistry; Protons; Retinaldehyde; Schiff Bases; Titrimetry | 2005 |
Effect of antiatherogenic L-aspartate and L-glutamate on serum lipoproteins cholesterol and apolipoproteins A-1 and B in rabbits fed with high cholesterol diet.
Topics: Animals; Apolipoprotein A-I; Apolipoproteins; Apolipoproteins B; Arteriosclerosis; Aspartic Acid; Cholesterol; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Diet, Atherogenic; Disease Models, Animal; Glutamic Acid; Male; Rabbits; Random Allocation; Triglycerides | 2005 |
Binuclear Cu2+ complex mediated discrimination between L-glutamate and L-aspartate in water.
Topics: Aspartic Acid; Copper; Electrochemistry; Glutamic Acid; Organometallic Compounds; Water | 2005 |
Isolation, structure determination, synthesis, and sensory activity of N-phenylpropenoyl-L-amino acids from cocoa (Theobroma cacao).
Topics: Amides; Amino Acids; Aspartic Acid; Cacao; Chromatography, High Pressure Liquid; Cinnamates; Glutamic Acid; Humans; Isomerism; Molecular Structure; Seeds; Taste; Tyrosine | 2005 |
A helical hairpin region of soluble annexin B12 refolds and forms a continuous transmembrane helix at mildly acidic pH.
Topics: Annexins; Aspartic Acid; Binding Sites; Calcium; Crystallography, X-Ray; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Lipid Bilayers; Models, Molecular; Mutation; Nitric Oxide; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Spin Labels; Thermodynamics | 2005 |
Acute up-regulation of glutamate uptake mediated by mGluR5a in reactive astrocytes.
Topics: Amino Acid Transport System X-AG; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biotinylation; Blotting, Western; Calcium; Carbachol; Cells, Cultured; Cholinergic Agonists; Chromones; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Glycine; Immunohistochemistry; Methoxyhydroxyphenylglycol; Phorbol Esters; Protein Kinase C; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium; Tritium; Type C Phospholipases | 2005 |
Disruption of left-right reciprocal coupling in the spinal cord of larval lamprey abolishes brain-initiated locomotor activity.
Topics: Analysis of Variance; Animals; Aspartic Acid; Behavior, Animal; Brain; Electromyography; Escape Reaction; Evoked Potentials, Motor; Functional Laterality; Glutamic Acid; In Vitro Techniques; Interneurons; Larva; Motor Activity; Muscles; Neural Inhibition; Periodicity; Petromyzon; Physical Stimulation; Psychomotor Performance; Pyramidal Tracts; Spinal Cord; Spinal Cord Injuries | 2005 |
Functional assessment of glutamate clearance mechanisms in a chronic rat glaucoma model using retinal ganglion cell calcium imaging.
Topics: Animals; Animals, Newborn; Aspartic Acid; Calcium; Cells, Cultured; Diagnostic Imaging; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Fura-2; Glaucoma; Glutamic Acid; In Vitro Techniques; Intraocular Pressure; Male; N-Methylaspartate; Optic Nerve; Rats; Rats, Long-Evans; Retina; Retinal Ganglion Cells; Time Factors | 2005 |
[Effects of glutamate transport inhibitor on organotypic cultured spinal cord slices].
Topics: Animals; Aspartic Acid; Biological Transport; Glutamic Acid; Hydro-Lyases; Immunohistochemistry; Motor Neurons; Organ Culture Techniques; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Cord | 2005 |
Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Blotting, Western; Cell Death; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Gene Expression Regulation, Developmental; Glutamic Acid; Heptanes; Heterocyclic Compounds, 3-Ring; Hippocampus; Homeostasis; Humans; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Time Factors; Tritium | 2005 |
Amino acids and transaminases activity in ventricular CSF and in brain of normal and Alzheimer patients.
Topics: Aged; Aged, 80 and over; Alanine Transaminase; Alzheimer Disease; Amino Acids; Aspartate Aminotransferases; Aspartic Acid; Brain; Brain Chemistry; Cerebrospinal Fluid; Female; Glutamic Acid; Glutamine; Humans; Lateral Ventricles; Male; Middle Aged; Reference Values; Transaminases; Up-Regulation | 2005 |
Influence of Na(+), dicarboxylic amino acids, and pH in modulating the low-calcium response of Yersinia pestis.
Topics: Amino Acids, Dicarboxylic; Aspartic Acid; Calcium; Glutamic Acid; Hydrogen-Ion Concentration; Sodium; Time Factors; Yersinia enterocolitica; Yersinia pestis; Yersinia pseudotuberculosis | 2005 |
Change in content of sugars and free amino acids in potato tubers under short-term storage at low temperature and the effect on acrylamide level after frying.
Topics: Acrylamide; Amino Acids; Asparagine; Aspartic Acid; Carbohydrate Metabolism; Chromatography, High Pressure Liquid; Cold Temperature; Color; Cooking; Food Handling; Food Preservation; Fructose; Glucose; Glutamic Acid; Glutamine; Solanum tuberosum; Time Factors | 2005 |
Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep--wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats.
Topics: Animals; Aspartic Acid; Dopamine; Electrophoresis, Capillary; Electrophysiology; Extracellular Space; Glutamic Acid; Male; Microdialysis; Norepinephrine; Nucleus Accumbens; Polysomnography; Prefrontal Cortex; Rats; Rats, Wistar; Sleep; Sleep, REM; Wakefulness | 2005 |
The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia.
Topics: Adrenergic alpha-Agonists; Animals; Aspartic Acid; Blood Glucose; Blood Pressure; Brain Chemistry; Brain Ischemia; Cell Death; Cell Survival; Chromatography, High Pressure Liquid; Clonidine; Glutamic Acid; Heart Rate; Hyperglycemia; Lactic Acid; Male; Nerve Degeneration; Prosencephalon; Rats; Rats, Sprague-Dawley; Visual Fields | 2005 |
Impaired glutamine metabolism in NMDA receptor hypofunction induced by MK801.
Topics: Animals; Aspartic Acid; Brain; Cell Communication; Dizocilpine Maleate; Down-Regulation; Energy Metabolism; Excitatory Amino Acid Antagonists; Frontal Lobe; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Glutathione; Inositol; Male; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Succinic Acid; Temporal Lobe; Up-Regulation | 2005 |
Local stability identification and the role of key acidic amino acid residues in staphylococcal nuclease unfolding.
Topics: Aspartic Acid; Calorimetry, Differential Scanning; Circular Dichroism; Enzyme Stability; Glutamic Acid; Micrococcal Nuclease; Mutation; Protein Denaturation; Protein Folding; Protein Structure, Tertiary; Spectrometry, Fluorescence; Temperature; Thermodynamics | 2005 |
Giardia lamblia RNA cap guanine-N2 methyltransferase (Tgs2).
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Catalysis; Centrifugation, Density Gradient; Dose-Response Relationship, Drug; Giardia lamblia; Glutamic Acid; Glycerol; Green Fluorescent Proteins; Guanine; Guanosine; Guanosine Triphosphate; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Methylation; Methyltransferases; Molecular Sequence Data; Recombinant Proteins; RNA; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Substrate Specificity; Time Factors; Transfection; tRNA Methyltransferases; Tryptophan | 2005 |
Apparent pKa shifts of titratable residues at high denaturant concentration and the impact on protein stability.
Topics: Aspartic Acid; Chemical Phenomena; Chemistry, Physical; Glutamic Acid; Guanidine; Histidine; Hydrogen-Ion Concentration; Lysine; Magnetic Resonance Spectroscopy; Protein Folding; Proteins; Sensitivity and Specificity; Titrimetry; Urea | 2005 |
Thyrotropin-releasing hormone (protirelin) inhibits potassium-stimulated glutamate and aspartate release from hippocampal slices in vitro.
Topics: Animals; Aspartic Acid; Calcium; Chromatography, High Pressure Liquid; Drug Interactions; Glutamic Acid; Hippocampus; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Potassium; Rats; Rats, Sprague-Dawley; Thyrotropin-Releasing Hormone; Time Factors | 2005 |
The Glu298Asp variant of the endothelial nitric oxide synthase gene is associated with an increased risk for abruptio placentae in pre-eclampsia.
Topics: Abruptio Placentae; Adolescent; Adult; Aspartic Acid; Case-Control Studies; Female; Gene Frequency; Genetic Variation; Glutamic Acid; Humans; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymerase Chain Reaction; Polymorphism, Genetic; Pre-Eclampsia; Pregnancy; Restriction Mapping; Risk Factors; South Africa | 2005 |
The amino-terminal domain of ClpB supports binding to strongly aggregated proteins.
Topics: Amino Acid Motifs; Aspartic Acid; Binding Sites; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Endopeptidase Clp; Escherichia coli Proteins; Glucosephosphate Dehydrogenase; Glutamic Acid; Heat-Shock Proteins; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Transport; Time Factors | 2005 |
Amino acid concentrations in chinchilla cochlear nucleus at different times after carboplatin treatment.
Topics: Amino Acids; Animals; Antineoplastic Agents; Aspartic Acid; Carboplatin; Chinchilla; Cochlear Nucleus; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hair Cells, Auditory, Inner | 2005 |
Differential effects of the Zn-His-Bkb vs Zn-His-[Asp/Glu] triad on Zn-core stability and reactivity.
Topics: Aspartic Acid; Catalytic Domain; Electron Transport; Enzymes; Glutamic Acid; Histidine; Humans; Ligands; Metalloproteins; Protein Conformation; Zinc | 2005 |
Evidence that gabapentin reduces neuropathic pain by inhibiting the spinal release of glutamate.
Topics: Amines; Analgesics; Animals; Aspartic Acid; Chronic Disease; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Foot; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Injections, Intraperitoneal; Injections, Spinal; Male; Neuralgia; Rats; Rats, Long-Evans; Spinal Cord; Spinal Cord Compression | 2005 |
Relationship of taurine and other amino acids in plasma and in neutrophils of septic trauma patients.
Topics: Adult; Amino Acids; Aspartic Acid; Glutamic Acid; Humans; Middle Aged; Neutrophils; Retrospective Studies; Sepsis; Taurine; Wounds and Injuries | 2006 |
pH dependence of amide chemical shifts in natively disordered polypeptides detects medium-range interactions with ionizable residues.
Topics: Amides; Aspartic Acid; Calorimetry, Differential Scanning; Escherichia coli; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Ions; Magnetic Resonance Spectroscopy; Mutagenesis; Peptides; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Protons; Temperature; Thioredoxins; Time Factors | 2005 |
Prevalence of eNOS Glu298Asp polymorphism in healthy volunteers from a region of Northern India.
Topics: Amino Acid Substitution; Aspartic Acid; DNA; Electrophoresis, Agar Gel; Genetic Carrier Screening; Genotype; Glutamic Acid; Homozygote; Humans; India; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide; Restriction Mapping | 2005 |
Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other.
Topics: Alanine; Amino Acid Substitution; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 3; Glutamic Acid; Glutamine; Humans; Mutagenesis, Site-Directed; Protein Subunits; Rats | 2005 |
Long-term treatment of rats with haloperidol: lack of an effect on brain N-acetyl aspartate levels.
Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Dopamine Antagonists; Drug Administration Schedule; Glutamic Acid; Glutamine; Haloperidol; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley | 2006 |
Patterned expression of Purkinje cell glutamate transporters controls synaptic plasticity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Calcium; Cannabinoids; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 4; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Glutamic Acid; In Vitro Techniques; Long-Term Synaptic Depression; Membrane Potentials; Methoxyhydroxyphenylglycol; Neuronal Plasticity; Patch-Clamp Techniques; Purkinje Cells; Quinoxalines; Rats; Synapses | 2005 |
DNA-sequence determination of exon 2 of a novel HLA-DPB1 allele, HLA-DPB1*0403.
Topics: Alanine; Alleles; Aspartic Acid; Base Sequence; Black People; Cloning, Molecular; Databases, Genetic; Glutamic Acid; Haplotypes; Heterozygote; HLA-DP Antigens; HLA-DP beta-Chains; Humans; Molecular Sequence Data; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Risk Factors; Sequence Analysis, DNA | 2005 |
The GLU298ASP variant of nitric oxide synthase interacts with asymmetric dimethyl arginine in determining cardiovascular mortality in patients with end-stage renal disease.
Topics: Adult; Aged; Amino Acid Substitution; Analysis of Variance; Arginine; Aspartic Acid; Cardiovascular Diseases; Female; Gene Frequency; Genotype; Glutamic Acid; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide Synthase; Polymorphism, Genetic; Regression Analysis; Survival Rate | 2005 |
Release of L-aspartate by reversal of glutamate transporters.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Glutamic Acid; Hydrogen-Ion Concentration; Membrane Potentials; Neuroglia; Potassium; Retina; Urodela | 2005 |
New haplotype for the Glu104Asp mutation in triose-phosphate isomerase deficiency and prenatal diagnosis in a Spanish family.
Topics: Aspartic Acid; CD4 Antigens; DNA Restriction Enzymes; Evolution, Molecular; Family Health; Female; Glutamic Acid; Haplotypes; Heterozygote; Humans; Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Pregnancy; Prenatal Diagnosis; Sequence Analysis, DNA; Spain; Triose-Phosphate Isomerase | 2005 |
Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.
Topics: Alanine; Aspartic Acid; Binding Sites; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Escherichia coli; Glutamic Acid; Humans; Kinetics; Mass Spectrometry; Mixed Function Oxygenases; Models, Molecular; Mutation; Oxidoreductases, O-Demethylating; Protein Binding; Protein Structure, Tertiary; Quinidine; Spectrophotometry; Substrate Specificity | 2005 |
Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Calcium; Diagnostic Imaging; Drug Interactions; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Membrane Potentials; Microscopy, Confocal; Neurons; Neurotoxins; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetanus Toxin; Tetrodotoxin; Time Factors | 2005 |
Optimized diffusion-weighted spectroscopy for measuring brain glutamate apparent diffusion coefficient on a whole-body MR system.
Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Diffusion; Diffusion Magnetic Resonance Imaging; Glutamic Acid; Humans; Inositol; Macaca | 2005 |
Glutamatergic stimulation of the medial amygdala induces steroid dependent c-fos expression within forebrain nuclei responsive to mating stimulation.
Topics: Amygdala; Animals; Aspartic Acid; Copulation; Drug Combinations; Estradiol; Excitatory Amino Acids; Female; Glutamic Acid; Glycine; Immunohistochemistry; Ovariectomy; Progesterone; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Long-Evans; Receptors, Glutamate; Steroids | 2005 |
Effects of prenatal paraquat and mancozeb exposure on amino acid synaptic transmission in developing mouse cerebellar cortex.
Topics: Animals; Aspartic Acid; Cerebellar Cortex; Disease Models, Animal; Down-Regulation; Female; Fungicides, Industrial; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Herbicides; Hyperkinesis; Maneb; Mice; Motor Activity; Neural Inhibition; Paraquat; Pregnancy; Prenatal Exposure Delayed Effects; Synaptic Transmission; Zineb | 2005 |
Endothelial NO synthase polymorphisms and postural tachycardia syndrome.
Topics: Adolescent; Adult; Alleles; Aspartic Acid; Case-Control Studies; Cysteine; Female; Genotype; Glutamic Acid; Heart Rate; Homozygote; Humans; Male; Middle Aged; Nitric Oxide Synthase Type III; Norepinephrine; Polymorphism, Genetic; Posture; Severity of Illness Index; Syndrome; Tachycardia; Threonine | 2005 |
Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cell Line; Cerebellum; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutamic Acid; Green Fluorescent Proteins; Humans; In Vitro Techniques; Membrane Potentials; Microinjections; Microscopy, Fluorescence, Multiphoton; Oocytes; Patch-Clamp Techniques; Purkinje Cells; Rats; Sodium; Transfection; Tritium; Xenopus | 2005 |
Metabolic fates of ammonia-N in ruminal epithelial and duodenal mucosal cells isolated from growing sheep.
Topics: Alanine; Ammonia; Animals; Arginine; Aspartic Acid; Citrulline; Duodenum; Epithelium; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Intestinal Mucosa; Nitrogen; Nitrogen Isotopes; Rumen; Sheep; Urea | 2005 |
Effects of the inhibitors on glutamate uptake by nerve terminals after exposure of rats to centrifuge-induced hypergravity.
Topics: Animals; Aspartic Acid; Biological Transport; Centrifugation; Dose-Response Relationship, Drug; Glutamic Acid; Hypergravity; Male; Rats; Rats, Wistar; Synaptosomes | 2004 |
High-frequency, but not low-frequency, transcutaneous electrical nerve stimulation reduces aspartate and glutamate release in the spinal cord dorsal horn.
Topics: Animals; Arthritis, Experimental; Aspartic Acid; Carrageenan; Chromatography, High Pressure Liquid; Glutamic Acid; Joints; Microdialysis; Naltrexone; Narcotic Antagonists; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Transcutaneous Electric Nerve Stimulation | 2005 |
High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.
Topics: Aging; Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Creatine; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Membrane Glycoproteins; Mice; Mice, Knockout; Models, Biological; Molecular Chaperones; Neuronal Ceroid-Lipofuscinoses; Neurotransmitter Agents; Phenotype; Spectrophotometry; Time Factors | 2005 |
Molecular dynamics simulations of bovine rhodopsin: influence of protonation states and different membrane-mimicking environments.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Amino Acid Sequence; Animals; Aspartic Acid; Carbon Tetrachloride; Cattle; Cell Membrane; Computer Simulation; Glutamic Acid; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Protons; Rhodopsin; Software; Structural Homology, Protein; Water | 2005 |
The impact of acute hypoglycemia on neuropsychological and neurometabolite profiles in children with type 1 diabetes.
Topics: Acute Disease; Aspartic Acid; Attention; Blood Glucose; Child; Diabetes Mellitus, Type 1; Female; Follow-Up Studies; Glucose; Glutamic Acid; Glutamine; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Incidence; Inositol; Insulin; Male; Memory; Memory, Short-Term; Methylamines; Neuropsychological Tests; Nuclear Magnetic Resonance, Biomolecular; Time Factors | 2005 |
Functional analysis of all aminotransferase proteins inferred from the genome sequence of Corynebacterium glutamicum.
Topics: Alanine; Aspartic Acid; Bacterial Proteins; Butyrates; Carbon-Sulfur Lyases; Corynebacterium glutamicum; Gene Deletion; Glutamic Acid; Hemiterpenes; Keto Acids; Phenylpyruvic Acids; Pyruvic Acid; Substrate Specificity; Transaminases | 2005 |
In vivo carbon-13 magnetization transfer effect. Detection of aspartate aminotransferase reaction.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Brain; Carbon Isotopes; Glutamic Acid; Ketoglutaric Acids; Magnetic Resonance Spectroscopy; Magnetics; Male; Neurotransmitter Agents; Oxaloacetic Acid; Rats; Rats, Sprague-Dawley | 2005 |
Pb(II)-binding capability of aminohydroxamic acids: primary hydroxamic acid derivatives of alpha-amino acids as possible sequestering agents for Pb(II).
Topics: Amino Acids; Aspartic Acid; Glutamic Acid; Hydrogen-Ion Concentration; Hydroxamic Acids; Lead; Ligands; Magnetic Resonance Spectroscopy; Metals, Heavy; Potentiometry; Protons | 2006 |
Active site structure of class I ribonucleotide reductase intermediate X: a density functional theory analysis of structure, energetics, and spectroscopy.
Topics: Aspartic Acid; Binding Sites; Electron Spin Resonance Spectroscopy; Glutamic Acid; Hydrogen Bonding; Iron; Models, Molecular; Molecular Structure; Ribonucleoside Diphosphate Reductase; Water | 2005 |
Selective serotonin re-uptake inhibition attenuates evoked glutamate release in the dorsal horn of the anaesthetised rat in vivo.
Topics: Anesthesia; Animals; Aspartic Acid; Citalopram; Glutamic Acid; Male; Microdialysis; Paroxetine; Piperazines; Posterior Horn Cells; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists | 2006 |
Application of classical molecular dynamics for evaluation of proton transfer mechanism on a protein.
Topics: Aspartic Acid; Glutamic Acid; Oxygen; Protein Structure, Secondary; Protons; Ribosomal Protein S6; Static Electricity; Water | 2005 |
Function of positive charges following signal-anchor sequences during translocation of the N-terminal domain.
Topics: Amino Acid Sequence; Animals; Arginine; Aspartic Acid; Chlorocebus aethiops; Cluster Analysis; COS Cells; Cycloheximide; DNA, Complementary; Dogs; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Gene Deletion; Glutamic Acid; Glycosylation; Lysine; Mice; Microsomes; Models, Biological; Molecular Sequence Data; Mutation; Peptides; Plasmids; Protein Conformation; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Protein Transport; Rabbits; Ribosomes; RNA, Messenger; Sequence Homology, Amino Acid; Synaptotagmin II; Transcription, Genetic | 2006 |
Brain magnetic resonance spectroscopy in Tourette's disorder.
Topics: Adolescent; Aspartic Acid; Brain; Brain Mapping; Child; Choline; Corpus Striatum; Creatine; Dominance, Cerebral; Energy Metabolism; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Nerve Net; Neurons; Reference Values; Thalamus; Tourette Syndrome | 2005 |
Excitatory amino acid concentrations increase in the spinal cord dorsal horn after repeated intramuscular injection of acidic saline.
Topics: Adaptation, Physiological; Animals; Aspartic Acid; Excitatory Amino Acids; Glutamic Acid; Hyperalgesia; Hyperesthesia; Injections, Intramuscular; Male; Myofascial Pain Syndromes; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sodium Chloride; Touch | 2005 |
Changes in plasma amino acids after electroconvulsive therapy of depressed patients.
Topics: Adult; Aged; Aspartic Acid; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencephalography; Electromyography; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Middle Aged; Time Factors; Tryptophan | 2005 |
Metabolite changes in early relapsing-remitting multiple sclerosis. A two year follow-up study.
Topics: Adult; Aspartic Acid; Choline; Creatine; Dipeptides; Female; Follow-Up Studies; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Statistics, Nonparametric; Time Factors | 2006 |
Glycosidation of cu,zn-superoxide dismutase with end-group aminated dextran: pharmacological and pharmacokinetics properties.
Topics: Amines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Aspartic Acid; Carbohydrate Sequence; Dextrans; Edema; Enzyme Activation; Foot Diseases; Glucosides; Glutamic Acid; Half-Life; Male; Molecular Sequence Data; Rats; Rats, Wistar; Superoxide Dismutase | 2005 |
Exploration of glycosyl hydrolase family 75, a chitosanase from Aspergillus fumigatus.
Topics: Amino Acid Sequence; Amino Acids; Aspartic Acid; Aspergillus fumigatus; Catalysis; Catalytic Domain; Chromatography, Ion Exchange; Chromatography, Liquid; Circular Dichroism; Cloning, Molecular; DNA; DNA Primers; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Gene Library; Glutamic Acid; Hydrolysis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Genetic; Molecular Sequence Data; Multigene Family; Mutagenesis, Site-Directed; Mutation; N-Glycosyl Hydrolases; Oligosaccharides; Plasmids; Polymerase Chain Reaction; Protein Sorting Signals; Recombinant Proteins; RNA; Sequence Homology, Amino Acid; Substrate Specificity; Temperature; Urea | 2006 |
Investigating brain metabolism at high fields using localized 13C NMR spectroscopy without 1H decoupling.
Topics: Animals; Aspartic Acid; Brain; Carbon Isotopes; Feasibility Studies; Glutamic Acid; Glutamine; Magnetic Resonance Spectroscopy; Monte Carlo Method; Rats; Signal Processing, Computer-Assisted | 2006 |
Crystal structure of human cytochrome P450 2D6.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Carbon Monoxide; Crystallography, X-Ray; Cytochrome P-450 CYP2D6; Glutamic Acid; Heme; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Software; Subcellular Fractions; Substrate Specificity | 2006 |
Na+ channel-mediated Ca2+ entry leads to glutamate secretion in mouse neocortical preplate.
Topics: Animals; Aspartic Acid; Brain; Calcium; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Mice; Mice, Inbred C57BL; Models, Biological; N-Methylaspartate; Neocortex; Neurons; Receptors, AMPA; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sodium; Sodium Channels; Software; Taurine; Time Factors; Veratridine | 2005 |
Changing the specificity of a bacterial chemoreceptor.
Topics: Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Chemoreceptor Cells; Chemotaxis; Culture Media; Cysteic Acid; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Membrane Proteins; Methyl-Accepting Chemotaxis Proteins; Molecular Sequence Data; N-Methylaspartate; Phenylalanine; Receptors, Amino Acid; Receptors, Cell Surface; Sequence Alignment | 2006 |
C-terminal truncation modulates both nucleation and extension phases of tau fibrillization.
Topics: Alzheimer Disease; Aspartic Acid; Caspases; Glutamic Acid; Humans; Membrane Proteins; Multiprotein Complexes; Protein Processing, Post-Translational | 2006 |
Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Aspartic Acid; Astrocytes; Blotting, Northern; Calcium; Carbachol; Cholinergic Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Humans; Immunohistochemistry; Male; Methoxyhydroxyphenylglycol; Protein Kinase C; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium; Superoxide Dismutase; Tritium | 2006 |
Sensitivity-enhanced 13C MR spectroscopy of the human brain at 3 Tesla.
Topics: Aspartic Acid; Brain Chemistry; Carbon Isotopes; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Image Enhancement; Lactates; Magnetic Resonance Spectroscopy; Sensitivity and Specificity; Signal Processing, Computer-Assisted | 2006 |
Brain magnetic resonance study of Mecp2 deletion effects on anatomy and metabolism.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain; Choline; CpG Islands; Energy Metabolism; Female; Gene Deletion; Genotype; Glutamic Acid; Glutamine; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mutation; Neuroglia; Neurons; Phenotype | 2006 |
Proton sensing of CLC-0 mutant E166D.
Topics: Animals; Aspartic Acid; Chloride Channels; Electric Conductivity; Female; Glutamic Acid; Hydrogen-Ion Concentration; Ion Channel Gating; Mathematics; Mutation; Oocytes; Patch-Clamp Techniques; Protons; Torpedo; Voltage-Dependent Anion Channels; Xenopus laevis | 2006 |
Olfactory nerve-evoked, metabotropic glutamate receptor-mediated synaptic responses in rat olfactory bulb mitral cells.
Topics: Amino Acids; Animals; Aspartic Acid; Benzoates; Dopamine D2 Receptor Antagonists; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA-B Receptor Antagonists; Glutamic Acid; Glycine; In Vitro Techniques; Male; Neuronal Plasticity; Neurons, Afferent; Odorants; Olfactory Bulb; Olfactory Nerve; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, GABA-B; Receptors, Metabotropic Glutamate; Synapses; Tacrine; Xanthenes | 2006 |
Optimization of dansyl derivatization and chromatographic conditions in the determination of neuroactive amino acids of biological samples.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Chromatography, High Pressure Liquid; Dansyl Compounds; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Rabbits; Rats; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Taurine; Trazodone | 2006 |
Short TE quantitative proton magnetic resonance spectroscopy in variant Creutzfeldt-Jakob disease.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Creatine; Creutzfeldt-Jakob Syndrome; Female; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Protons; Statistics, Nonparametric | 2006 |
Proton MRS of the unilateral substantia nigra in the human brain at 4 tesla: detection of high GABA concentrations.
Topics: Aspartic Acid; Feasibility Studies; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Humans; Magnetic Resonance Spectroscopy; Parkinson Disease; Protons; Substantia Nigra | 2006 |
Linker chains of the gigantic hemoglobin of the earthworm Lumbricus terrestris: primary structures of linkers L2, L3, and L4 and analysis of the connectivity of the disulfide bonds in linker L1.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Binding Sites; Calcium; Chromatography, High Pressure Liquid; Cysteine; Disulfides; Dithiothreitol; DNA, Complementary; Glutamic Acid; Heme; Hemoglobins; Histidine; Humans; Ligands; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Oligochaeta; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Receptors, LDL; RNA, Messenger; Sequence Homology, Amino Acid; Sodium Dodecyl Sulfate; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Superoxide Dismutase | 2006 |
APE1 genotype and risk of bladder cancer: evidence for effect modification by smoking.
Topics: Aged; Aspartic Acid; Case-Control Studies; DNA Damage; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Female; Genotype; Glutamic Acid; Guanine; Humans; Male; Mass Spectrometry; Middle Aged; North Carolina; Polymorphism, Genetic; Risk Assessment; Smoking; Thymine; Urinary Bladder Neoplasms | 2006 |
Circadian rhythms of prolactin secretion in neonatal female rabbits after acute separation from their mothers.
Topics: Animals; Animals, Newborn; Aspartic Acid; Circadian Rhythm; Dopamine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Lactation; Maternal Deprivation; Median Eminence; Pituitary Gland, Anterior; Prolactin; Rabbits; Serotonin; Taurine | 2006 |
P2X(7) receptors exert a permissive role on the activation of release-enhancing presynaptic alpha7 nicotinic receptors co-existing on rat neocortex glutamatergic terminals.
Topics: Adenosine Triphosphate; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Choline; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Enzyme Activation; Glutamic Acid; In Vitro Techniques; Magnesium; Male; Neocortex; Nicotine; Nicotinic Agonists; Presynaptic Terminals; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Time Factors; Tritium | 2006 |
TE-averaged two-dimensional proton spectroscopic imaging of glutamate at 3 T.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Mapping; Choline; Creatine; Echo-Planar Imaging; Fourier Analysis; Glutamic Acid; Glutamine; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Spectroscopy; Reference Values | 2006 |
Glutamate uptake block triggers deadly rhythmic bursting of neonatal rat hypoglossal motoneurons.
Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Biological Transport; Calcium; Carbenoxolone; Electrophysiology; Excitatory Amino Acid Antagonists; Gap Junctions; Glutamic Acid; Hypoglossal Nerve; Motor Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Tetrodotoxin; Time Factors | 2006 |
Structure, function, and wavelength selection in blue-absorbing proteorhodopsin.
Topics: Amino Acid Sequence; Archaeal Proteins; Arginine; Aspartic Acid; Bacterial Chromatophores; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Models, Molecular; Molecular Sequence Data; Retina; Rhodopsin; Rhodopsins, Microbial; Schiff Bases; Sensory Rhodopsins; Spectrophotometry; Static Electricity | 2006 |
Kynurenic acid synthesis in bovine retinal slices--effect of glutamate agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cattle; Excitatory Amino Acid Agonists; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Organ Culture Techniques; Retina | 2006 |
NMR study of the electron transfer complex of plant ferredoxin and sulfite reductase: mapping the interaction sites of ferredoxin.
Topics: Aspartic Acid; Chromatography, Affinity; Circular Dichroism; Crystallography, X-Ray; Electron Transport; Ferredoxins; Glutamic Acid; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Mutation; NADP; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; Plant Proteins; Protein Binding; Static Electricity; Temperature; Time Factors | 2006 |
Fragmentation of the deprotonated ions of peptides containing cysteine, cysteine sulfinic acid, cysteine sulfonic acid, aspartic acid, and glutamic acid.
Topics: Amino Acid Sequence; Aspartic Acid; Cysteine; Glutamic Acid; Molecular Sequence Data; Peptides; Spectrometry, Mass, Electrospray Ionization; Sulfonic Acids | 2006 |
Effect of morphine on the release of excitatory amino acids in the rat hind instep: Pain is modulated by the interaction between the peripheral opioid and glutamate systems.
Topics: Analgesics, Opioid; Animals; Aspartic Acid; Capsaicin; Disease Models, Animal; Drug Interactions; Electric Stimulation; Glutamic Acid; Hot Temperature; Male; Morphine; Narcotic Antagonists; Nerve Fibers, Unmyelinated; Neural Conduction; Nociceptors; Opioid Peptides; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Opioid; Sensory Receptor Cells; Signal Transduction | 2006 |
Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1.
Topics: Amino Acid Sequence; Amino Acid Transport System X-AG; Animals; Anions; Aspartic Acid; Binding Sites; Binding, Competitive; Biological Transport; Catalysis; Cell Line; Cell Membrane; Cloning, Molecular; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Transporter 3; Glutamic Acid; Humans; Ions; Kinetics; Lasers; Models, Biological; Models, Chemical; Models, Molecular; Molecular Sequence Data; Photolysis; Protein Binding; Rats; Sequence Homology, Amino Acid; Sodium; Time Factors; Transfection | 2006 |
Effects of theanine, r-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission.
Topics: Animals; Aspartic Acid; Brain; Dicarboxylic Acids; Dopamine; Glutamates; Glutamic Acid; Glycine; Male; Microdialysis; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar | 2005 |
Calculations of pH-dependent binding of proteins to biological membranes.
Topics: Aspartic Acid; Computer Simulation; Glutamic Acid; Hydrogen-Ion Concentration; Ions; Models, Molecular; Molecular Conformation; Peptides; Protein Binding; Protein Interaction Mapping; Proteins; Software; Solvents; Surface Properties; Thermodynamics | 2006 |
Synthetic peptides mimicking antigenic epitope of Helicobacter pylori urease.
Topics: Aspartic Acid; Atherosclerosis; Biochemistry; Chemistry, Pharmaceutical; Epitopes; Glutamic Acid; Helicobacter pylori; Humans; Immunoglobulin G; Models, Chemical; Peptides; Protein Binding; Urease | 2006 |
Excitatory amino acid release and electrocortical brain activity after hypoxemia in near-term lambs.
Topics: Animals; Animals, Newborn; Aspartic Acid; Blood Glucose; Brain; Electroencephalography; Female; Gestational Age; Glutamic Acid; Hypoxia; Lactic Acid; Pregnancy; Sheep | 2006 |
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents, Phytogenic; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Line, Tumor; Docetaxel; Drug Resistance, Neoplasm; Epothilones; Glutamic Acid; Humans; Mice; Mice, Nude; Microtubules; Paclitaxel; Point Mutation; Protein Conformation; Taxoids; Tubulin; Verapamil | 2006 |
1H magnetic resonance spectroscopy at 3 T in cryptogenic and mesial temporal lobe epilepsy.
Topics: Adult; Aspartic Acid; Choline; Creatine; Epilepsy, Temporal Lobe; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged | 2006 |
NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes.
Topics: Animals; Aspartic Acid; Astrocytes; Cerebral Cortex; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Green Fluorescent Proteins; Humans; Membrane Potentials; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Peptides, Cyclic; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2006 |
Increased glutamate levels in the vitreous of patients with retinal detachment.
Topics: Aspartic Acid; Female; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Neurotransmitter Agents; Retinal Detachment; Retrospective Studies; Taurine; Visual Acuity; Vitrectomy; Vitreous Body | 2006 |
Modulation of calcium entry and glutamate release in cultured cerebellar granule cells by palytoxin.
Topics: Acrylamides; Animals; Animals, Newborn; Aspartic Acid; Calcium; Calcium Channels; Calcium Signaling; Calcium-Transporting ATPases; Cell Membrane; Cells, Cultured; Cerebellar Cortex; Cnidarian Venoms; Cytosol; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Lithium; Mice; Neurons; Presynaptic Terminals; Receptors, Glutamate; Sodium; Sodium Channels; Sodium-Calcium Exchanger | 2006 |
Hyperthermia influences excitatory and inhibitory amino acid neurotransmitters in the central nervous system. An experimental study in the rat using behavioural, biochemical, pharmacological, and morphological approaches.
Topics: Animals; Aspartic Acid; Behavior, Animal; Blood-Brain Barrier; Brain; Capillary Permeability; Cerebrovascular Circulation; Cognition; Edema; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hyperthermia, Induced; Image Processing, Computer-Assisted; Male; Microscopy, Electron, Transmission; Motor Activity; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Rats; Rats, Wistar | 2006 |
Interactions of beta-lactoglobulin with sodium decylsulfonate, decyltriethylammonium bromide, and their mixtures.
Topics: Aspartic Acid; Binding Sites; Cations; Circular Dichroism; Glutamic Acid; Lactoglobulins; Models, Molecular; Protein Binding; Protein Conformation; Quaternary Ammonium Compounds; Sulfonic Acids; Surface-Active Agents | 2006 |
Electroreductive intramolecular coupling of aromatic imino esters: is four-membered cyclization much more favorable than six-membered cyclization?
Topics: Aspartic Acid; Azetidines; Cyclization; Esters; Glutamic Acid; Imines; Molecular Structure; Oxidation-Reduction; Pyrrolidinones; Stereoisomerism | 2006 |
Quantitative studies, taste reconstitution, and omission experiments on the key taste compounds in morel mushrooms (Morchella deliciosa Fr.).
Topics: Adult; Ascomycota; Aspartic Acid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Malates; Male; Monosaccharides; Solutions; Succinic Acid; Taste | 2006 |
Survey of catalytic residues and essential roles of glutamate-alpha170 and aspartate-alpha335 in coenzyme B12-dependent diol dehydratase.
Topics: Aspartic Acid; Bacterial Proteins; Catalytic Domain; Cobamides; Glutamic Acid; Kinetics; Klebsiella oxytoca; Mutagenesis, Site-Directed; Propanediol Dehydratase; Structure-Activity Relationship; Substrate Specificity | 2006 |
Cortical excitatory amino acid release and cell function during hypotension in near-term born lambs.
Topics: Animals; Animals, Newborn; Aspartic Acid; Brain Mapping; Cerebral Cortex; Excitatory Amino Acids; Extracellular Fluid; Female; Glutamic Acid; Intracranial Hypotension; Pregnancy; Sheep | 2006 |
Hyaluronic acid attenuates osteoarthritis development in the anterior cruciate ligament-transected knee: Association with excitatory amino acid release in the joint dialysate.
Topics: Animals; Anterior Cruciate Ligament Injuries; Aspartic Acid; Cartilage, Articular; Excitatory Amino Acids; Glutamic Acid; Hyaluronic Acid; Injections, Intra-Articular; Knee Injuries; Male; Microdialysis; Osteoarthritis; Rats; Rats, Wistar | 2006 |
Positive correlations between cerebral choline and renal dysfunction in chronic renal failure.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Female; Glutamic Acid; Humans; Kidney Failure, Chronic; Kidney Function Tests; Magnetic Resonance Spectroscopy; Male; Middle Aged; Sensitivity and Specificity | 2006 |
Rotavirus spike protein VP5* binds alpha2beta1 integrin on the cell surface and competes with virus for cell binding and infectivity.
Topics: Animals; Aspartic Acid; Capsid Proteins; Cell Line; Glutamic Acid; Glycine; Humans; Integrin alpha2beta1; Receptors, Virus; Recombinant Proteins; Rotavirus; Rotavirus Infections; Species Specificity; Viral Nonstructural Proteins; Virus Replication | 2006 |
Glutamate levels in aqueous humor of patients with retinal artery occlusion.
Topics: Aged; Aged, 80 and over; Alanine; Aqueous Humor; Aspartic Acid; Chromatography, High Pressure Liquid; Female; Glutamic Acid; Humans; Male; Retinal Artery Occlusion; Taurine | 2006 |
NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat.
Topics: Animals; Aspartic Acid; Brain Injuries; Cytoprotection; Dipeptides; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamate Carboxypeptidase II; Glutamic Acid; Hippocampus; Male; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Up-Regulation | 2006 |
Conformational changes in protein loops and helices induced by post-translational phosphorylation.
Topics: Algorithms; Animals; Aspartic Acid; Computational Biology; Cyclin-Dependent Kinase 2; Databases, Protein; Glutamic Acid; Humans; Molecular Conformation; Phosphorylation; Protein Conformation; Protein Processing, Post-Translational; Protein Structure, Tertiary | 2006 |
L-glutamate activates RhoA GTPase leading to suppression of astrocyte stellation.
Topics: Actins; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Blotting, Western; Cell Size; Cells, Cultured; Cerebral Cortex; Chlorides; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glutamic Acid; GTP Phosphohydrolases; Immunohistochemistry; Manganese Compounds; Protein Transport; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Signal Transduction; Time Factors | 2006 |
Glutamate leakage from a compartmentalized intracellular metabolic pool and activation of the lipoxygenase pathway mediate oxidative astrocyte death by reversed glutamate transport.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Brain; Brain Ischemia; Cell Compartmentation; Cell Death; Cells, Cultured; Cytoprotection; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Transporter 1; Extracellular Fluid; Glutamic Acid; Intracellular Fluid; Lipoxygenase; Mice; Oxidative Stress; Rats | 2006 |
Nanocomposites of hydroxyapatite with aspartic acid and glutamic acid and their interaction with osteoblast-like cells.
Topics: Aspartic Acid; Cell Line; Durapatite; Glutamic Acid; Humans; Microscopy, Electron, Scanning; Nanotechnology; Osteoblasts; X-Ray Diffraction | 2006 |
Excitatory aminoacid neurotransmitters in schizophrenia.
Topics: Adolescent; Adult; Aspartic Acid; Bangladesh; Case-Control Studies; Disease Progression; Excitatory Amino Acids; Female; Glutamic Acid; Humans; Male; Middle Aged; Schizophrenia | 2005 |
The Campylobacter jejuni PEB1a adhesin is an aspartate/glutamate-binding protein of an ABC transporter essential for microaerobic growth on dicarboxylic amino acids.
Topics: Aerobiosis; Amino Acids, Dicarboxylic; Animals; Antigens, Bacterial; Aspartic Acid; ATP-Binding Cassette Transporters; Bacterial Proteins; Campylobacter jejuni; Culture Media; Glutamic Acid; Humans; Recombinant Proteins; Subcellular Fractions | 2006 |
Sporadic ALS is not associated with VAPB gene mutations in Southern Italy.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Aspartic Acid; Base Sequence; Case-Control Studies; Exons; Female; Gene Frequency; Genetic Variation; Glutamic Acid; Humans; Introns; Italy; Male; Middle Aged; Mutation; Vesicular Transport Proteins | 2006 |
N-acetylaspartate as a reservoir for glutamate.
Topics: Aspartic Acid; Astrocytes; Brain; Citric Acid Cycle; Dipeptides; Glutamic Acid; Humans; Models, Biological; Neurons; Neurotransmitter Agents; Oligodendroglia | 2006 |
Free amino acids in the nervous system of the amphioxus Branchiostoma lanceolatum. A comparative study.
Topics: Amino Acids; Animals; Aspartic Acid; Chordata; Chromatography, High Pressure Liquid; D-Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Nervous System; Taurine | 2006 |
Low cerebrospinal fluid glutamate and glycine in refractory affective disorder.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Chromatography, High Pressure Liquid; Depressive Disorder, Major; Drug Resistance; Electroconvulsive Therapy; Female; Glutamic Acid; Glycine; Humans; Male; Middle Aged; N-Methylaspartate; Statistics as Topic | 2007 |
Free energy calculations show that acidic P1 variants undergo large pKa shifts upon binding to trypsin.
Topics: Aprotinin; Aspartic Acid; Binding Sites; Computer Simulation; Crystallography, X-Ray; Entropy; Glutamic Acid; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Serine Endopeptidases; Structure-Activity Relationship; Substrate Specificity; Thermodynamics; Trypsin; Trypsin Inhibitors | 2006 |
Comprehensive examination of charged intramembrane residues in a nucleoside transporter.
Topics: Animals; Aspartic Acid; Biological Transport; Cell Membrane; Glutamic Acid; Leishmania donovani; Lysine; Membrane Transport Modulators; Nucleoside Transport Proteins; Protein Binding; Protein Structure, Tertiary; Protozoan Proteins; Substrate Specificity | 2006 |
Glial glutamate transporters maintain one-to-one relationship at the climbing fiber-Purkinje cell synapse by preventing glutamate spillover.
Topics: Animals; Animals, Newborn; Aspartic Acid; Benzothiadiazines; Cerebellum; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 1; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Methacrylates; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers; Neural Inhibition; Phosphorylcholine; Purkinje Cells; Synapses | 2006 |
Asp302 determines potassium dependence of a RadA recombinase from Methanococcus voltae.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Archaeal Proteins; Aspartic Acid; Crystallography, X-Ray; DNA-Binding Proteins; Electrons; Glutamic Acid; Hydrolysis; Lysine; Methanococcus; Mutation; Potassium; Protein Structure, Secondary; Protein Subunits; Sodium | 2006 |
The pH-dependence of amide chemical shift of Asp/Glu reflects its pKa in intrinsically disordered proteins with only local interactions.
Topics: Amides; Amino Acid Sequence; Aspartic Acid; Escherichia coli Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Conformation; Protein Folding; Static Electricity; Thioredoxins | 2006 |
Chemically accurate protein structures: validation of protein NMR structures by comparison of measured and predicted pKa values.
Topics: Aspartic Acid; Crystallography, X-Ray; Databases, Protein; Glutamic Acid; Hydrogen-Ion Concentration; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Proteins; Software | 2006 |
Limits on activation-induced temperature and metabolic changes in the human primary visual cortex.
Topics: Adult; Algorithms; Analysis of Variance; Aspartic Acid; Body Temperature; Cerebrovascular Circulation; Choline; Female; Glutamic Acid; Humans; Inositol; Lactates; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Photic Stimulation; Visual Cortex | 2006 |
Insights into amprenavir resistance in E35D HIV-1 protease mutation from molecular dynamics and binding free-energy calculations.
Topics: Amino Acid Substitution; Aspartic Acid; Carbamates; Drug Resistance, Viral; Furans; Glutamic Acid; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Protein Binding; Sulfonamides; Thermodynamics | 2007 |
A periplasmic glutamate/aspartate binding protein from Shigella flexneri: Gene cloning, over-expression, purification and preliminary crystallographic studies of the recombinant protein.
Topics: Amino Acid Sequence; Aspartic Acid; Cloning, Molecular; Crystallography, X-Ray; Glutamic Acid; Molecular Sequence Data; Periplasm; Periplasmic Binding Proteins; Protein Conformation; Recombinant Proteins; Sequence Alignment; Shigella flexneri | 2006 |
Regulation of NAA-synthesis in the human brain in vivo: Canavan's disease, Alzheimer's disease and schizophrenia.
Topics: Alzheimer Disease; Aspartic Acid; Brain; Canavan Disease; Child; Glutamic Acid; Humans; Magnetic Resonance Imaging; Molecular Structure; Schizophrenia | 2006 |
Synthesis of N-acetylaspartyl-glutamate (NAAG) and N-acetylaspartate (NAA) in axons and glia of the crayfish medial giant nerve fiber.
Topics: Animals; Aspartic Acid; Astacoidea; Axons; Dipeptides; Glutamic Acid; Nerve Fibers; Neuroglia | 2006 |
Lack of association between NOS3 Glu298Asp and breast cancer risk: a case-control study.
Topics: Aspartic Acid; Breast Neoplasms; Case-Control Studies; Female; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Glutamic Acid; Humans; Nitric Oxide Synthase Type III; Odds Ratio; Polymorphism, Genetic; Risk Assessment; Risk Factors; Spain | 2006 |
C-terminal amino acid residue loss for deprotonated peptide ions containing glutamic acid, aspartic acid, or serine residues at the C-terminus.
Topics: Amino Acid Sequence; Amino Acids; Aspartic Acid; Cyclotrons; Glutamic Acid; Mass Spectrometry; Oxygen Isotopes; Peptides; Protons; Serine | 2006 |
Low-molecular-weight chromium-binding substance from chicken liver and American alligator liver.
Topics: Adipocytes; Alligators and Crocodiles; Animals; Aspartic Acid; Chickens; Chromium; Glutamic Acid; In Vitro Techniques; Liver Extracts; Male; Oligopeptides; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Species Specificity | 2006 |
Effect of Saffron (Crocus sativus) on neurobehavioral and neurochemical changes in cerebral ischemia in rats.
Topics: Animals; Antioxidants; Aspartic Acid; Behavior; Brain; Brain Chemistry; Brain Ischemia; Catalase; Crocus; Disease Models, Animal; Flowers; Glutamic Acid; Glutathione; Hand Strength; Lipid Peroxidation; Male; Malondialdehyde; Motor Activity; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Superoxide Dismutase | 2006 |
Cholesterol deficiency perturbs actin signaling and glutamate homeostasis in hippocampal astrocytes.
Topics: Actins; Analysis of Variance; Animals; Aspartic Acid; Astrocytes; beta-Cyclodextrins; Cell Size; Cells, Cultured; Cholesterol; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Lovastatin; Microtubule-Associated Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Tritium | 2006 |
[Effect of dahuang zhechong pill on content of amino acids in hippocampal tissue of ischemic cerebral hemorrhagic rats].
Topics: Amino Acids; Animals; Aspartic Acid; Cerebral Hemorrhage; Drugs, Chinese Herbal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Phytotherapy; Rats; Rats, Sprague-Dawley | 2006 |
The crystal structure of Deinococcus radiodurans Dps protein (DR2263) reveals the presence of a novel metal centre in the N terminus.
Topics: Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Crystallography, X-Ray; Deinococcus; DNA-Binding Proteins; Glutamic Acid; Histidine; Iron; Ligands; Models, Molecular; Molecular Sequence Data; Sequence Alignment; Zinc | 2006 |
Differential distribution of L-aspartate- and L-glutamate-immunoreactive structures in the arcopallium and medial striatum of the domestic chick (Gallus domesticus).
Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Chickens; Corpus Striatum; Glutamic Acid; Immunohistochemistry; Microscopy, Electron; Neurons; Neurotransmitter Agents | 2006 |
Probing the role of E272 in quinol oxidation of mitochondrial complex III.
Topics: Amino Acid Substitution; Aspartic Acid; Binding Sites; Electron Spin Resonance Spectroscopy; Electron Transport Complex III; Enzyme Stability; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Oxidation-Reduction; Potentiometry; Saccharomyces cerevisiae Proteins; Spectroscopy, Fourier Transform Infrared; Superoxides; Ubiquinone | 2006 |
Catalytic role of proton transfers in the formation of a tetrahedral adduct in a serine carboxyl peptidase.
Topics: Aspartic Acid; Aspartic Acid Endopeptidases; Binding Sites; Carboxypeptidases; Catalysis; Computer Simulation; Energy Transfer; Enzyme Inhibitors; Glutamic Acid; Hydrogen-Ion Concentration; Protons; Serine; Thermodynamics | 2006 |
Endothelial nitric oxide synthase Glu298Asp gene polymorphism in periodontal diseases.
Topics: Acute Disease; Adolescent; Adult; Amino Acid Substitution; Aspartic Acid; Chi-Square Distribution; Chronic Disease; Female; Genetic Predisposition to Disease; Glutamic Acid; Humans; Logistic Models; Male; Middle Aged; Mutation, Missense; Nitric Oxide Synthase Type III; Periodontal Index; Periodontitis; Polymorphism, Single Nucleotide; Severity of Illness Index; Statistics, Nonparametric; Turkey | 2006 |
The neurochemical basis of human cortical auditory processing: combining proton magnetic resonance spectroscopy and magnetoencephalography.
Topics: Acoustic Stimulation; Adolescent; Adult; Age Factors; Aged; Aspartic Acid; Auditory Cortex; Choline; Evoked Potentials, Auditory; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Magnetoencephalography; Male; Middle Aged | 2006 |
Role of Asp544 in subunit I for Na(+) pumping by Vitreoscilla cytochrome bo.
Topics: Amino Acid Substitution; Aminoacridines; Aspartic Acid; Bacterial Proteins; Cation Transport Proteins; Cytochrome b Group; Fluorescent Dyes; Glutamic Acid; Ion Transport; Multienzyme Complexes; Mutagenesis, Site-Directed; NADH, NADPH Oxidoreductases; Protein Subunits; Protons; Sodium; Spectrum Analysis; Vitreoscilla | 2006 |
Selective peptide chain extension at the N-terminus of aspartic and glutamic acids utilizing 1-(N-protected-alpha-aminoacyl)benzotriazoles.
Topics: Aminoacylation; Aspartic Acid; Chromatography, High Pressure Liquid; Glutamic Acid; Magnetic Resonance Spectroscopy; Oligopeptides; Stereoisomerism; Triazoles | 2006 |
Selective peptide chain extension at the C-terminus of aspartic and glutamic acids utilizing N-protected (alpha-aminoacyl)benzotriazoles.
Topics: Aminoacylation; Aspartic Acid; Chromatography, High Pressure Liquid; Glutamic Acid; Magnetic Resonance Spectroscopy; Oligopeptides; Stereoisomerism; Triazoles | 2006 |
MR spectroscopy: predicting long-term neuropsychological outcome following pediatric TBI.
Topics: Adolescent; Aspartic Acid; Brain Injuries; Child; Child, Preschool; Creatine; Female; Glutamic Acid; Glutamine; Humans; Infant; Inositol; Linear Models; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Predictive Value of Tests; Recovery of Function; Statistics, Nonparametric | 2006 |
Cognitive impairment and in vivo metabolites in first-episode neuroleptic-naive and chronic medicated schizophrenic patients: a proton magnetic resonance spectroscopy study.
Topics: Adult; Aged; Antipsychotic Agents; Aspartic Acid; Choline; Chronic Disease; Cognition Disorders; Creatine; Dominance, Cerebral; Energy Metabolism; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mental Recall; Middle Aged; Neurons; Phosphocreatine; Prefrontal Cortex; Psychiatric Status Rating Scales; Reference Values; Schizophrenia; Verbal Learning | 2007 |
Regarding "Increased prefrontal and hippocampal glutamate concentration in schizophrenia: evidence from a magnetic resonance spectroscopy study".
Topics: Aspartic Acid; Choline; Creatine; Dominance, Cerebral; Glutamic Acid; Gyrus Cinguli; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Phosphocreatine; Prefrontal Cortex; Reference Values; Schizophrenia; Thalamus | 2007 |
Species-specific chemosignals evoke delayed excitation of the vomeronasal amygdala in freely-moving female rats.
Topics: Amygdala; Animals; Aspartic Acid; Behavior, Animal; Chemoreceptor Cells; Estrous Cycle; Female; gamma-Aminobutyric Acid; Globulins; Glutamic Acid; Hormones; Luteinizing Hormone; Microdialysis; Neurotransmitter Agents; Progesterone; Proteinuria; Rats; Rats, Wistar; Signal Transduction; Smell; Sodium Channel Blockers; Stimulation, Chemical; Taurine; Tetrodotoxin; Urine; Vomeronasal Organ | 2006 |
In vivo monitoring of extracellular glutamate in the brain with a microsensor.
Topics: Animals; Aspartic Acid; Biological Assay; Brain; Down-Regulation; Excitatory Amino Acid Agonists; Extracellular Fluid; Glutamic Acid; Hydrogel, Polyethylene Glycol Dimethacrylate; Male; Microelectrodes; Molecular Probe Techniques; Neurochemistry; Potassium Chloride; Rats; Rats, Wistar; Sodium Channel Blockers | 2006 |
5-Hydroxytryptamine-mediated increase in glutamate uptake by the leech giant glial cell.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Bucladesine; Cell Membrane; Central Nervous System; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Ganglia, Invertebrate; Glutamic Acid; Hirudo medicinalis; Membrane Potentials; Neuroglia; Neurons; Patch-Clamp Techniques; Receptors, G-Protein-Coupled; Serotonin; Signal Transduction; Sodium; Synaptic Transmission; Up-Regulation | 2006 |
Regulation of FNR dimerization by subunit charge repulsion.
Topics: Alanine; Amino Acid Substitution; Apoproteins; Aspartic Acid; Circular Dichroism; Dimerization; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Iron; Iron-Sulfur Proteins; Models, Molecular; Oxygen; Protein Structure, Tertiary; Protein Subunits; Sulfur; Trypsin | 2006 |
Monitoring extracellular glutamate in hippocampal slices with a microsensor.
Topics: Animals; Aspartic Acid; Biological Assay; Drug Interactions; Extracellular Fluid; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Molecular Probe Techniques; Neurotransmitter Uptake Inhibitors; Rats; Rats, Wistar; Sodium Channel Blockers; Veratridine | 2007 |
Aspartic acid 405 contributes to the substrate specificity of aminopeptidase B.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Aminopeptidases; Animals; Arginine; Aspartic Acid; Epoxide Hydrolases; Glutamic Acid; Hydrolysis; Kinetics; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Proteins; Protein Binding; Rats; Recombinant Proteins; Sequence Alignment; Structure-Activity Relationship; Substrate Specificity | 2006 |
The ionic stoichiometry of the GLAST glutamate transporter in salamander retinal glia.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Computer Simulation; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Excitatory Amino Acid Transporter 5; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Models, Biological; Neuroglia; Patch-Clamp Techniques; Potassium; Protons; Retina; Sodium; Urodela | 2006 |
Roles of Asp75, Asp78, and Glu83 of GTP-dependent phosphoenolpyruvate carboxykinase from Mycobacterium smegmatis.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Binding Sites; Cytosol; Glutamic Acid; Humans; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mycobacterium smegmatis; Oxaloacetic Acid; Phosphoenolpyruvate Carboxykinase (GTP); Protein Binding; Sequence Homology, Amino Acid | 2006 |
The AauR-AauS two-component system regulates uptake and metabolism of acidic amino acids in Pseudomonas putida.
Topics: Amino Acids, Acidic; Aspartic Acid; Biomass; Cloning, Molecular; Gene Amplification; Glutamic Acid; Phylogeny; Polymerase Chain Reaction; Pseudomonas putida; RNA, Ribosomal, 16S | 2006 |
Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist.
Topics: Aspartic Acid; Binding Sites; Calcium; Chemokine CCL1; Chemokine CCL4; Chemokines, CC; Chemotaxis; Glutamic Acid; Ligands; Macrophage Inflammatory Proteins; Protein Binding; Protein Structure, Tertiary; Receptors, CCR8; Receptors, Chemokine; Serine; Structure-Activity Relationship; Viral Proteins | 2006 |
Capillary electrophoresis with electrochemiluminescence detection for measurement of aspartate aminotransferase and alanine aminotransferase activities in biofluids.
Topics: Alanine; Alanine Transaminase; Aspartate Aminotransferases; Aspartic Acid; Body Fluids; Diagnosis, Differential; Electrophoresis, Capillary; Ethanol; Female; Glutamic Acid; Hepatitis; Humans; Hydrogen-Ion Concentration; Liver Diseases, Alcoholic; Luminescent Measurements; Male; Reproducibility of Results; Sensitivity and Specificity | 2006 |
Characterization of the tritium-labeled analog of L-threo-beta-benzyloxyaspartate binding to glutamate transporters.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Chlorocebus aethiops; COS Cells; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Kinetics; Protein Binding; Radioisotope Dilution Technique; Recombinant Proteins; Sodium; Transfection; Tritium | 2007 |
Aspartic acid side chain effect-experimental and theoretical insight.
Topics: Aspartic Acid; Cyclotrons; Glutamic Acid; Molecular Structure; Peptide Fragments; Peptides; Protons; Spectroscopy, Fourier Transform Infrared | 2007 |
Determination of aspartate and glutamate in rabbit retina using polymer monolith microextraction coupled to high-performance liquid chromatography with fluorescence detection.
Topics: Animals; Aspartic Acid; Calibration; Chromatography, High Pressure Liquid; Fluorescence; Glutamic Acid; Hydrogen-Ion Concentration; Hypertension; Molecular Structure; Polymers; Rabbits; Retina | 2006 |
Response of hippocampal mossy fiber zinc to excessive glutamate release.
Topics: Animals; Aspartic Acid; Calcium; Chelating Agents; Chromatography, High Pressure Liquid; Extracellular Space; Glutamic Acid; In Vitro Techniques; Male; Microdialysis; Mossy Fibers, Hippocampal; Potassium; Pyramidal Cells; Rats; Rats, Wistar; Stimulation, Chemical; Synapses; Zinc | 2007 |
Catalytic site modifications of TAP1 and TAP2 and their functional consequences.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP Binding Cassette Transporter, Subfamily B, Member 3; ATP-Binding Cassette Transporters; Baculoviridae; Binding Sites; Catalytic Domain; Cell Line, Tumor; Genetic Vectors; Glutamic Acid; Glutamine; Histidine; Humans; Nucleotides; Protein Transport | 2006 |
Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution 1H NMR spectroscopy.
Topics: Animals; Aspartic Acid; Data Interpretation, Statistical; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Inositol; Magnetic Resonance Spectroscopy; Male; Morphine; Narcotics; Prefrontal Cortex; Principal Component Analysis; Rats; Rats, Sprague-Dawley; Taurine | 2007 |
Role of divalent metal cations in ATP hydrolysis catalyzed by the hepatitis C virus NS3 helicase: magnesium provides a bridge for ATP to fuel unwinding.
Topics: Adenosine Triphosphate; Aspartic Acid; Binding Sites; Catalysis; Cations; Fluorescence Resonance Energy Transfer; Glutamic Acid; Hydrolysis; Kinetics; Magnesium; Metals; Models, Chemical; Nucleotides; Viral Nonstructural Proteins | 2007 |
Single voxel proton magnetic resonance spectroscopy in post-stroke depression.
Topics: Aged; Aspartic Acid; Cerebral Infarction; Choline; Creatine; Depressive Disorder; Dominance, Cerebral; Energy Metabolism; Female; Follow-Up Studies; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Synaptic Transmission; Tomography, X-Ray Computed | 2006 |
Enhancement of MALDI-MS spectra of C-terminal peptides by the modification of proteins via an active ester generated in situ from an oxazolone.
Topics: Acetic Anhydrides; Amides; Amino Acid Sequence; Arginine; Aspartic Acid; Esters; Fluorobenzenes; Formates; Glutamic Acid; Guanidine; Hydrazines; Imidazoles; Molecular Sequence Data; Oxazolone; Peptides; Phenols; Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2006 |
Developmental changes in retrograde messengers involved in depolarization-induced suppression of excitation at parallel fiber-Purkinje cell synapses in rodents.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cannabinoid Receptor Modulators; Cell Differentiation; Cell Membrane; Cerebellar Cortex; Excitatory Amino Acid Agonists; GluK2 Kainate Receptor; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Organ Culture Techniques; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Kainic Acid; Second Messenger Systems; Signal Transduction; Synapses; Synaptic Transmission | 2007 |
Adolescent anorexia nervosa: cross-sectional and follow-up frontal gray matter disturbances detected with proton magnetic resonance spectroscopy.
Topics: Adolescent; Anorexia Nervosa; Aspartic Acid; Body Mass Index; Body Weight; Child; Choline; Combined Modality Therapy; Cross-Sectional Studies; Female; Follow-Up Studies; Frontal Lobe; Glutamic Acid; Glutamine; Hospitalization; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neuropsychological Tests; Reference Values | 2007 |
Reduced aspartate release from rat hippocampal synaptosomes loaded with Clostridial toxin light chain by electroporation: evidence for an exocytotic mechanism.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electroporation; Female; Glutamic Acid; Hippocampus; Neurotoxins; Potassium Chloride; Rats; Synaptosomes; Tetanus Toxin | 2007 |
Of folding and function: understanding active-site context through metalloenzyme design.
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Calcium; Circular Dichroism; DNA; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Glutamic Acid; Helix-Turn-Helix Motifs; Hydrolysis; Kinetics; Lanthanoid Series Elements; Metalloproteins; Molecular Sequence Data; Phosphates; Protein Folding; Substrate Specificity | 2006 |
Mutational analysis of cytochrome b at the ubiquinol oxidation site of yeast complex III.
Topics: Aspartic Acid; Binding Sites; Crystallization; Cytochromes b; Cytochromes c; DNA Mutational Analysis; Electron Transport Complex III; Enzyme Activation; Enzyme Stability; Glutamic Acid; Kinetics; Mutagenesis, Site-Directed; Oxidation-Reduction; Phenylalanine; Saccharomyces cerevisiae; Tyrosine; Ubiquinone | 2007 |
Modulation of the functional binding sites for TGF-beta on the type II receptor leads to suppression of TGF-beta signaling.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Cell Line; Cell Proliferation; Chlorocebus aethiops; Conserved Sequence; Glutamic Acid; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Quaternary; Protein Structure, Tertiary; Receptors, Transforming Growth Factor beta; Sequence Alignment; Signal Transduction; Transforming Growth Factor beta | 2007 |
Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: no association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene.
Topics: Aspartic Acid; Autistic Disorder; Chromosome Mapping; DNA Mutational Analysis; DNA Primers; DNA, Mitochondrial; Gene Expression; Gene Frequency; Glutamic Acid; Haplotypes; Humans; Lactic Acid; Membrane Transport Proteins; Mitochondrial Diseases; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Pyruvic Acid | 2006 |
Taurine, taurine analogues, and taurine functions: overview.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Kainic Acid; Male; Microdialysis; Motor Activity; Quinoxalines; Rats; Rats, Wistar; Taurine; Tetrodotoxin | 2006 |
Acute alterations of glutamate, glutamine, GABA, and other amino acids after spinal cord contusion in rats.
Topics: Animals; Aspartic Acid; Citrulline; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Rats; Rats, Wistar; Spinal Cord Injuries; Taurine | 2007 |
The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies.
Topics: Aged; Aspartic Acid; Case-Control Studies; Female; Glutamic Acid; Humans; Integrin alpha2; Interleukin-13; Ischemia; Male; Middle Aged; Nitric Oxide Synthase Type III; P-Selectin; Polymorphism, Single Nucleotide; Receptors, CCR2; Receptors, Chemokine; Stroke | 2007 |
Amino acid contribution to protein solubility: Asp, Glu, and Ser contribute more favorably than the other hydrophilic amino acids in RNase Sa.
Topics: Amino Acids; Ammonium Sulfate; Aspartic Acid; Electric Conductivity; Exoribonucleases; Glutamic Acid; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Protein Structure, Tertiary; Proteins; Ribonucleases; Salts; Serine; Solubility; Structure-Activity Relationship | 2007 |
Conformational coupling between the cytoplasmic carboxylic acid and the retinal in a fungal light-driven proton pump.
Topics: Amino Acid Substitution; Ascomycota; Asparagine; Aspartic Acid; Carboxylic Acids; Cytoplasm; Glutamic Acid; Lasers; Neurospora; Protein Conformation; Proton Pumps; Retinaldehyde; Rhodopsin | 2006 |
[Effect of dialysis time in vivo on recovery of amino acids for micro-dialysis probe].
Topics: Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Chromatography, High Pressure Liquid; Dialysis Solutions; gamma-Aminobutyric Acid; Glutamic Acid; Microdialysis; Rats; Rats, Sprague-Dawley; Time Factors | 2006 |
Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Chemistry; Choline; Creatine; Depressive Disorder, Major; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Psychiatric Status Rating Scales | 2007 |
The essential oil of bergamot enhances the levels of amino acid neurotransmitters in the hippocampus of rat: implication of monoterpene hydrocarbons.
Topics: Amino Acid Transport Systems; Amino Acids; Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Exocytosis; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Male; Microdialysis; Monoterpenes; Neurotransmitter Agents; Oils, Volatile; Plant Oils; Rats; Rats, Wistar; Synaptosomes; Taurine; Time Factors | 2007 |
Effect of signal-to-noise ratio and spectral linewidth on metabolite quantification at 4 T.
Topics: Aspartic Acid; Creatine; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Phosphorylcholine | 2007 |
Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects.
Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Bipolar Disorder; Brain Mapping; Depressive Disorder; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Matched-Pair Analysis; Middle Aged; Occipital Lobe; Reference Values | 2007 |
Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Brain; Calcium; Glutamic Acid; Kinetics; Malates; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mitochondria, Heart; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Molecular Sequence Data; Muscle, Skeletal; NAD | 2007 |
Mechanism of methanol oxidation by quinoprotein methanol dehydrogenase.
Topics: Alcohol Oxidoreductases; Aspartic Acid; Binding Sites; Carbon Dioxide; Catalysis; Computer Simulation; Glutamic Acid; Methanol; Models, Molecular; Oxidation-Reduction; Protein Structure, Tertiary | 2007 |
Novel syntheses of chiral beta- and gamma-amino acid derivatives utilizing N-protected (aminoacyl)benzotriazoles from aspartic and glutamic acids.
Topics: Amino Acids; Aspartic Acid; Glutamic Acid; Molecular Structure; Stereoisomerism; Triazoles | 2007 |
Functional and structural characterization of D-aspartate oxidase from porcine kidney: non-Michaelis kinetics due to substrate activation.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; D-Aspartate Oxidase; Dicarboxylic Acids; Female; Glutamic Acid; Kidney; Kinetics; Molecular Sequence Data; N-Methylaspartate; Oxygen; Sequence Alignment; Sus scrofa | 2007 |
Strengths of hydrogen bonds involving phosphorylated amino acid side chains.
Topics: Amides; Amino Acids; Aspartic Acid; Computer Simulation; Glutamic Acid; Hydrogen Bonding; Phosphorylation; Protein Processing, Post-Translational; Serine; Sodium Chloride | 2007 |
Vanilloid (subtype 1) receptor-modulatory drugs inhibit [3H]batrachotoxinin-A 20-alpha-benzoate binding to Na+ channels.
Topics: Animals; Aspartic Acid; Batrachotoxins; Brain; Capsaicin; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Potassium Chloride; Sodium Channels; Synaptosomes; Tritium; TRPV Cation Channels; Veratridine | 2007 |
A combined spectroscopic and functional MRI investigation of the dorsal anterior cingulate region in opiate addiction.
Topics: Adaptation, Physiological; Adult; Analysis of Variance; Arousal; Aspartic Acid; Brain Mapping; Case-Control Studies; Cerebellum; Female; Frontal Lobe; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Male; Matched-Pair Analysis; Opioid-Related Disorders; Parietal Lobe; Psychomotor Performance; Time Factors | 2007 |
Sensitivity-encoded (SENSE) proton echo-planar spectroscopic imaging (PEPSI) in the human brain.
Topics: Aspartic Acid; Brain Chemistry; Choline; Creatine; Echo-Planar Imaging; Feasibility Studies; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Spectroscopy; Phantoms, Imaging | 2007 |
Novel strategy for cerebral 13C MRS using very low RF power for proton decoupling.
Topics: Animals; Aspartic Acid; Brain; Carbon Isotopes; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Macaca mulatta; Magnetic Resonance Spectroscopy; Protons | 2007 |
Monitoring the pH dependence of IR carboxylic acid signals upon Q(B)- formation in the Glu-L212 --> Asp/Asp-L213 --> Glu swap mutant reaction center from Rhodobacter sphaeroides.
Topics: Amino Acid Sequence; Aspartic Acid; Carboxylic Acids; Deuterium Exchange Measurement; Electron Transport; Glutamic Acid; Hydrogen-Ion Concentration; Mutation; Photosynthetic Reaction Center Complex Proteins; Protons; Quinones; Rhodobacter sphaeroides; Spectroscopy, Fourier Transform Infrared | 2007 |
The carboxylate shift in zinc enzymes: a computational study.
Topics: Aspartic Acid; Carboxylic Acids; Catalytic Domain; Computational Biology; Crystallography, X-Ray; Cysteine; Electron Transport; Enzymes; Glutamic Acid; Histidine; Ligands; Metalloproteins; Oxygen; Protein Conformation; Zinc | 2007 |
Cerebellar granule neurons are more vulnerable to transient transport-mediated glutamate release than to glutamate uptake blockade. correlation with excitatory amino acids levels.
Topics: Animals; Aspartic Acid; Biological Transport; Cells, Cultured; Cerebellum; Excitatory Amino Acids; Glutamic Acid; Neurons; Rats; Rats, Wistar | 2007 |
Membrane currents and cytoplasmic sodium transients generated by glutamate transport in Bergmann glial cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Calcium; Cerebellum; Cytoplasm; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagonists; Glucosamine; Glutamic Acid; Kainic Acid; Lithium; Membrane Potentials; Mice; Mice, Inbred Strains; Models, Biological; Nerve Fibers; Neuroglia; Sodium; Sodium-Calcium Exchanger | 2007 |
Memory performance of hypercholesterolemic mice in response to treatment with soy isoflavones.
Topics: Acetylcholinesterase; Animals; Aspartic Acid; Avoidance Learning; Behavior, Animal; Brain; Chi-Square Distribution; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Glutamic Acid; Hypercholesterolemia; Isoflavones; Male; Memory; Mice; Mice, Inbred Strains; Soybean Proteins; Triglycerides | 2007 |
Further evidence for altered myelin biosynthesis and glutamatergic dysfunction in schizophrenia.
Topics: Adult; Aged; Amidohydrolases; Aspartic Acid; Cadaver; Case-Control Studies; Fatty Acids; Female; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Male; Middle Aged; Myelin Sheath; Oligodendroglia; Prefrontal Cortex; Receptors, Metabotropic Glutamate; RNA, Messenger; Schizophrenia; Synaptic Transmission | 2007 |
Changes of amino acid concentrations in the rat medial vestibular nucleus following unilateral labyrinthectomy.
Topics: Amino Acids; Animals; Aspartic Acid; Ear, Inner; Glutamic Acid; Male; Rats; Rats, Wistar; Taurine; Vestibular Nuclei | 2007 |
Hippocampal sclerosis: MR prediction of seizure intractability.
Topics: Adult; Aspartic Acid; Choline; Creatine; Epilepsy, Temporal Lobe; Female; Functional Laterality; Glutamic Acid; Glutamine; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Prognosis; Sclerosis; Severity of Illness Index; Temporal Lobe | 2007 |
Metabolite findings in tumefactive demyelinating lesions utilizing short echo time proton magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Demyelinating Diseases; Diagnosis, Differential; Echo-Planar Imaging; Female; Glutamic Acid; Humans; Lactic Acid; Male; Middle Aged; Multiple Sclerosis; Protons | 2007 |
Reduced cingulate glutamate/glutamine-to-creatine ratios in adult patients with attention deficit/hyperactivity disorder -- a magnet resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Choline; Creatine; Dominance, Cerebral; Dopamine; Female; Germany; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Prefrontal Cortex | 2007 |
Movements and muscle activity initiated by brain locomotor areas in semi-intact preparations from larval lamprey.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Brain Mapping; Electromyography; Functional Laterality; Glutamic Acid; In Vitro Techniques; Lampreys; Larva; Movement; Muscles | 2007 |
Association of eNOS Glu298Asp gene polymorphism with circadian blood pressure rhythm.
Topics: Adult; Aged; Aspartic Acid; Blood Pressure; Circadian Rhythm; Glutamic Acid; Humans; Hypertension; Middle Aged; Nitric Oxide Synthase Type III; Polymorphism, Genetic | 2007 |
Glutamate measurement in Parkinson's disease using MRS at 3 T field strength.
Topics: Antiparkinson Agents; Aspartic Acid; Corpus Striatum; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Levodopa; Magnetic Resonance Spectroscopy; Parkinson Disease; Reference Values | 2007 |
Predicting DNA-binding amino acid residues from electrostatic stabilization upon mutation to Asp/Glu and evolutionary conservation.
Topics: Amino Acids; Aspartic Acid; Binding Sites; Computational Biology; Conserved Sequence; Databases, Protein; DNA-Binding Proteins; Evolution, Molecular; Glutamic Acid; Models, Molecular; Mutation; Protein Structure, Secondary; Protein Structure, Tertiary; Static Electricity; Structure-Activity Relationship | 2007 |
Role of homologous ASP334 and GLU319 in human non-gastric H,K- and Na,K-ATPases in cardiac glycoside binding.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid; Binding, Competitive; Biological Transport; Cardiac Glycosides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glutamic Acid; H(+)-K(+)-Exchanging ATPase; Humans; Membrane Potentials; Mutation; Oocytes; Ouabain; Protein Subunits; Proton Pump Inhibitors; Rabbits; Rats; Rubidium Radioisotopes; Sequence Homology, Amino Acid; Sodium-Potassium-Exchanging ATPase; Xenopus laevis | 2007 |
Neuroprotective potential of ceftriaxone in in vitro models of stroke.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anti-Bacterial Agents; Aspartic Acid; Ceftriaxone; Cell Death; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Hippocampus; Hypoxia; Membrane Potentials; Neurons; Neuroprotective Agents; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Stroke; Time Factors | 2007 |
Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.
Topics: Anesthetics, Local; Arginine; Aspartic Acid; Binding Sites; Cell Line; Cell Membrane Permeability; Glutamic Acid; Humans; Ion Channel Gating; Kinetics; Lidocaine; Lysine; Membrane Potentials; Models, Molecular; Molecular Structure; Muscle Proteins; Mutagenesis, Site-Directed; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Phenylalanine; Protein Conformation; Sodium Channel Blockers; Sodium Channels; Static Electricity; Transfection | 2007 |
Protein kinase C-mediated modulation of glutamate transporter activity in rat retina.
Topics: Acetophenones; Alkaloids; Animals; Aspartic Acid; Benzophenanthridines; Benzopyrans; Cell Culture Techniques; Enzyme Inhibitors; Excitatory Amino Acid Transporter 1; Glutamic Acid; Immunoenzyme Techniques; Neuroglia; Protein Kinase C-delta; Rats; Retina | 2007 |
The neuronal pathology of schizophrenia: molecules and mechanisms.
Topics: Animals; Aspartic Acid; Brain; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; Neurons; Phencyclidine; Schizophrenia | 2007 |
Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population.
Topics: Adaptor Proteins, Signal Transducing; Adult; Amino Acid Substitution; Asian People; Aspartic Acid; Brain; Brain Chemistry; DNA Mutational Analysis; DNA-Binding Proteins; Female; Genetic Markers; Genetic Predisposition to Disease; Genetic Testing; Genotype; Glutamic Acid; Humans; Japan; Male; Middle Aged; Mutation; Mutation, Missense; Nerve Tissue Proteins; Polymorphism, Genetic; Schizophrenia; Tumor Suppressor Proteins | 2007 |
Recognition of the N-terminal lectin domain of FimH adhesin by the usher FimD is required for type 1 pilus biogenesis.
Topics: Adhesins, Escherichia coli; Aspartic Acid; Escherichia coli Proteins; Fimbriae Proteins; Fimbriae, Bacterial; Glutamic Acid; Humans; Immunoglobulins; Lectins; Mutant Proteins; Protein Binding; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Sequence Deletion | 2007 |
Cooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1.
Topics: Amino Acid Sequence; Animals; Anions; Aspartic Acid; Cell Line; Conserved Sequence; Electrochemistry; Excitatory Amino Acid Transporter 3; Glutamic Acid; Humans; Kidney; Kinetics; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Protein Structure, Tertiary; Rats; Sodium | 2007 |
Glutamine as an energy substrate in cultured neurons during glucose deprivation.
Topics: Animals; Aspartic Acid; Cells, Cultured; Chromatography, High Pressure Liquid; Energy Metabolism; Glucose; Glutamic Acid; Glutamine; Mice; Neurons; Oxygen Consumption | 2007 |
Brain energy metabolism and neurotransmission at near-freezing temperatures: in vivo (1)H MRS study of a hibernating mammal.
Topics: Animals; Ascorbic Acid; Aspartic Acid; Brain; Brain Chemistry; Choline; Cold Temperature; Creatine; Energy Metabolism; Ethanolamines; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Glutathione; Hibernation; Inositol; Lactic Acid; Magnetic Resonance Spectroscopy; Phosphocreatine; Sciuridae; Synaptic Transmission; Taurine | 2007 |
Polymorphisms in the paraoxonase and endothelial nitric oxide synthase genes and the risk of early-onset myocardial infarction.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Arginine; Aryldialkylphosphatase; Aspartic Acid; Cohort Studies; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Glutamine; Humans; Male; Middle Aged; Myocardial Infarction; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide; Prospective Studies; Risk Factors | 2007 |
Glycogen is a preferred glutamate precursor during learning in 1-day-old chick: biochemical and behavioral evidence.
Topics: Animals; Animals, Newborn; Arabinose; Aspartic Acid; Astrocytes; Behavior, Animal; Brain; Brain Chemistry; Chickens; Chromatography, High Pressure Liquid; Deoxyglucose; Glutamic Acid; Glutamine; Glycogen; Imino Furanoses; Learning; Neurons; Sugar Alcohols | 2007 |
Evidence that alpha7 nicotinic receptor modulates glutamate release from mouse neocortical gliosomes.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Aspartic Acid; Astrocytes; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; Calcium Signaling; Cell Communication; Glutamic Acid; Mice; Neocortex; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Subcellular Fractions; Synaptic Transmission | 2007 |
MRI and MRS alterations in the preclinical phase of murine prion disease: association with neuropathological and behavioural changes.
Topics: Animals; Aspartic Acid; Astrocytes; Body Water; Brain; Choline; Creatine; Diffusion; Disease Models, Animal; Disease Progression; Gliosis; Glucose; Glutamic Acid; Hyperkinesis; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Microglia; Prion Diseases | 2007 |
TBOA-sensitive uptake limits glutamate penetration into brain slices to a few micrometers.
Topics: Animals; Aspartic Acid; Brain; Glutamic Acid; Mice; Mice, Inbred C57BL; Organ Culture Techniques; Patch-Clamp Techniques | 2007 |
Caveolae nitration of Janus kinase-2 at the 1007Y-1008Y site: coordinating inflammatory response and metabolic hormone readjustment within the somatotropic axis.
Topics: Amino Acid Sequence; Animals; Antibodies; Antioxidants; Aspartic Acid; Binding Sites; Cattle; Caveolae; Epitopes; Glutamic Acid; Inflammation; Insulin-Like Growth Factor I; Janus Kinase 2; Lipopolysaccharides; Molecular Sequence Data; Nitrates; Nitric Oxide Synthase Type III; Phosphorylation; Rabbits; RNA, Messenger; Stress, Physiological; Suppressor of Cytokine Signaling Proteins; Tyrosine; Vitamin E | 2007 |
The protonation state of the Glu-71/Asp-80 residues in the KcsA potassium channel: a first-principles QM/MM molecular dynamics study.
Topics: Animals; Aspartic Acid; Bacterial Proteins; Biological Transport; Biophysics; Crystallography, X-Ray; Glutamic Acid; Ions; Mice; Models, Molecular; Molecular Conformation; Potassium; Potassium Channels; Protein Conformation; Protons; Static Electricity | 2007 |
Conformational changes in a bacterial multidrug transporter are phosphatidylethanolamine-dependent.
Topics: Amino Acid Substitution; Aspartic Acid; Bacterial Proteins; Glutamic Acid; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Phosphatidylethanolamines; Protein Conformation; Spectroscopy, Fourier Transform Infrared; Substrate Specificity; Tryptophan | 2007 |
Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter.
Topics: Alanine; Animals; Aspartic Acid; Binding Sites; Cysteine; Dicarboxylic Acid Transporters; Excitatory Amino Acid Transporter 3; Glutamic Acid; HeLa Cells; Humans; Microinjections; Mutation; Neurons; Oocytes; Protein Conformation; Protein Structure, Tertiary; Rabbits; Serine; Succinic Acid; Transfection; Xenopus laevis | 2007 |
Active-site properties of the oxidized and reduced C-terminal domain of DsbD obtained by NMR spectroscopy.
Topics: Amino Acid Motifs; Aspartic Acid; Binding Sites; Cysteine; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Models, Molecular; Mutation; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Oxidoreductases; Protein Structure, Tertiary | 2007 |
Amino acid composition of two masticatory nuts (Cola acuminata and Garcinia kola) and a snack nut (Anacardium occidentale).
Topics: Amino Acids; Amino Acids, Acidic; Amino Acids, Essential; Anacardium; Arginine; Aspartic Acid; Cola; Cystine; Garcinia kola; Glutamic Acid; Isoelectric Point; Nuts; Threonine; Valine | 2007 |
The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anti-Bacterial Agents; Aspartic Acid; beta-Lactams; Body Temperature; Ceftriaxone; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fever; Glutamic Acid; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Male; Morphine; Rats; Rats, Sprague-Dawley; Riluzole; Time Factors | 2007 |
[Extracellular aminoacids in the amygdala and nucleus accumbens in the rat during acute pain].
Topics: Acute Disease; Amygdala; Animals; Arginine; Aspartic Acid; Glutamic Acid; Male; Nucleus Accumbens; Pain; Rats; Rats, Wistar | 2007 |
Cell viability and proteomic analysis in cultured neurons exposed to methylmercury.
Topics: Animals; Apoptosis; Aspartic Acid; Blotting, Western; Cell Survival; Cells, Cultured; Dinoprost; Electrophoresis, Gel, Two-Dimensional; Glutamic Acid; Lipid Peroxidation; Mass Spectrometry; Mercury Poisoning, Nervous System; Methylmercury Compounds; Mice; Nerve Tissue Proteins; Neurons; Oxidative Stress; Proteomics; Synaptic Transmission | 2007 |
Neurochemical and structural correlates of executive dysfunction in schizophrenia.
Topics: Adult; Amygdala; Aspartic Acid; Atrophy; Brain; Cognition Disorders; Dominance, Cerebral; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Prefrontal Cortex; Problem Solving; Schizophrenia, Paranoid | 2008 |
Effect of the L- or D-aspartate on ecto-5'nucleotidase activity and on cellular viability in cultured neurons: participation of the adenosine A(2A) receptors.
Topics: 5'-Nucleotidase; Adenosine Monophosphate; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; D-Aspartic Acid; Glutamic Acid; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptor, Adenosine A2A | 2007 |
Metabolism of indole-3-acetic acid in rice: identification and characterization of N-beta-D-glucopyranosyl indole-3-acetic acid and its conjugates.
Topics: Amides; Aspartic Acid; Chromatography, Liquid; Glutamic Acid; Indoleacetic Acids; Indoles; Monosaccharides; Oryza; Plant Extracts; Plant Roots; Plant Shoots; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2007 |
Freezing and anoxia tolerance of slugs: a metabolic perspective.
Topics: Adaptation, Physiological; Alanine; Anaerobiosis; Animals; Aspartic Acid; Body Temperature Regulation; Energy Metabolism; Freezing; Gastropoda; Glucose; Glutamic Acid; Oxygen; Species Specificity; Succinic Acid | 2007 |
Two conformational changes are associated with glutamate translocation by the glutamate transporter EAAC1.
Topics: Algorithms; Aspartic Acid; Biological Transport; Cell Line; Excitatory Amino Acid Transporter 3; Excitatory Amino Acid Transporter 4; Glutamates; Glutamic Acid; Humans; Indoles; Kinetics; Membrane Potentials; Models, Molecular; Patch-Clamp Techniques; Protein Binding; Protein Conformation; Sodium; Temperature; Thermodynamics; Transfection | 2007 |
Generation of slow network oscillations in the developing rat hippocampus after blockade of glutamate uptake.
Topics: Animals; Aspartic Acid; Electrophysiology; Excitatory Amino Acid Antagonists; GABA-A Receptor Agonists; Glutamic Acid; Hippocampus; Interneurons; Neocortex; Nerve Net; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Vesicular Glutamate Transport Proteins | 2007 |
The determination of protonation states in proteins.
Topics: Aspartic Acid; Concanavalin A; Crystallography, X-Ray; Glutamic Acid; Hirudins; Histidine; Hydrogen Bonding; Models, Molecular; Peptide Fragments; Protein Structure, Tertiary; Proteins; Protons; Thrombin | 2007 |
Morphological and metabolic changes in the cortex of mice lacking the functional presynaptic active zone protein bassoon: a combined 1H-NMR spectroscopy and histochemical study.
Topics: Animals; Aspartic Acid; Brain Mapping; Cerebellum; Cerebral Cortex; Female; Glutamic Acid; Glutamine; Histocytochemistry; Male; Manganese; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Nerve Tissue Proteins; Neuroglia; Neurons; Nuclear Magnetic Resonance, Biomolecular; Presynaptic Terminals; Protons | 2008 |
Mechanisms of glutamate release elicited in rat cerebrocortical nerve endings by 'pathologically' elevated extraterminal K+ concentrations.
Topics: Animals; Aspartic Acid; Calcium Channels; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 2; Exocytosis; Extracellular Fluid; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hyperkalemia; Kainic Acid; Macrolides; Male; Potassium; Presynaptic Terminals; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Synaptosomes | 2007 |
N-methyl-D-aspartate autoreceptors respond to low and high agonist concentrations by facilitating, respectively, exocytosis and carrier-mediated release of glutamate in rat hippocampus.
Topics: Animals; Aspartic Acid; Autoreceptors; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exocytosis; Glutamic Acid; Glycine; Hippocampus; HIV Envelope Protein gp120; Male; N-Methylaspartate; Presynaptic Terminals; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Synaptosomes; Vesicular Glutamate Transport Proteins | 2007 |
High-sensitivity detection of biological amines using fast Hadamard transform CE coupled with photolytic optical gating.
Topics: Aspartic Acid; Electrophoresis, Capillary; Fluorescent Dyes; Glutamic Acid; Optics and Photonics | 2007 |
Mutations in transmembrane domains 5 and 7 of the human excitatory amino acid transporter 1 affect the substrate-activated anion channel.
Topics: Amino Acid Substitution; Animals; Anions; Aspartic Acid; Binding Sites; Biological Transport, Active; Cell Membrane Permeability; Electrophysiology; Excitatory Amino Acid Transporter 1; Female; Glutamic Acid; Humans; Ion Channel Gating; Ion Channels; Membrane Potentials; Models, Molecular; Mutation; Oocytes; Xenopus laevis | 2007 |
TFIIB/SUA7(E202G) is an allele-specific suppressor of TBP1(E186D).
Topics: Alleles; Aspartic Acid; Basic-Leucine Zipper Transcription Factors; Cell Cycle Proteins; DNA-Binding Proteins; Down-Regulation; Glutamic Acid; Glycine; Mutation; Protein Binding; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; TATA-Box Binding Protein; Temperature; Transcription Factor TFIIB; Transcription Factors | 2007 |
[Effects of volatile organic compounds on brain amino acid neurotransmitter in mice].
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Neurotransmitter Agents; Random Allocation; Volatile Organic Compounds | 2007 |
Effects of protective agents on membrane fluidity of freeze-dried Lactobacillus delbrueckii ssp. bulgaricus.
Topics: Aspartic Acid; Cell Membrane; Cell Survival; Cryoprotective Agents; Freeze Drying; Glutamic Acid; Lactobacillus delbrueckii; Membrane Fluidity; Preservation, Biological | 2007 |
Catalytic role of conserved HQGE motif in the CE6 carbohydrate esterase family.
Topics: Alternative Splicing; Amino Acid Motifs; Animals; Aspartic Acid; Carbohydrate Metabolism; Catalysis; Cattle; Conserved Sequence; Esterases; Glutamic Acid; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Phylogeny; Protein Structure, Tertiary; Substrate Specificity | 2007 |
Axonal damage but no increased glial cell activity in the normal-appearing white matter of patients with clinically isolated syndromes suggestive of multiple sclerosis using high-field magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Axons; Brain; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Neuroglia; Osmolar Concentration | 2007 |
Mechanism of formation of the ester linkage between heme and Glu310 of CYP4B1: 18O protein labeling studies.
Topics: Amino Acid Sequence; Aryl Hydrocarbon Hydroxylases; Aspartic Acid; Binding Sites; Esters; Glutamic Acid; Heme; Kinetics; Mass Spectrometry; Peptide Fragments; Polymerase Chain Reaction; Recombinant Proteins; Trypsin | 2007 |
Protonation and hydrogen bonding of Ca2+ site residues in the E2P phosphoenzyme intermediate of sarcoplasmic reticulum Ca2+-ATPase studied by a combination of infrared spectroscopy and electrostatic calculations.
Topics: Animals; Aspartic Acid; Calcium; Deuterium; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Ligands; Protein Conformation; Protons; Rabbits; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Spectrophotometry, Infrared; Static Electricity; Water | 2008 |
Mutations to bid cleavage sites protect hepatocytes from apoptosis after ischemia/reperfusion injury.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Apoptosis; Aspartic Acid; BH3 Interacting Domain Death Agonist Protein; Caspase 8; Glutamic Acid; Granzymes; Hepatocytes; Molecular Sequence Data; Mutation; Rats; Rats, Wistar; Reperfusion Injury | 2007 |
Homology modeling and examination of the effect of the D92E mutation on the H5N1 nonstructural protein NS1 effector domain.
Topics: Amino Acid Sequence; Aspartic Acid; Computer Simulation; Glutamic Acid; Influenza A Virus, H5N1 Subtype; Models, Molecular; Molecular Sequence Data; Mutation; Phosphorylation; Protein Kinases; Protein Structure, Tertiary; Sequence Alignment; Sequence Homology, Amino Acid; Structural Homology, Protein; Viral Nonstructural Proteins | 2007 |
Cerebral diffusion tensor imaging and in vivo proton magnetic resonance spectroscopy in patients with fulminant hepatic failure.
Topics: Adolescent; Adult; Anisotropy; Aspartic Acid; Biomarkers; Case-Control Studies; Cerebrovascular Circulation; Choline; Creatine; Diffusion Magnetic Resonance Imaging; Female; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parietal Lobe; Prognosis; Protons; Time Factors | 2008 |
Association of eNOS Glu298Asp gene polymorphism with essential hypertension in Asian Indians.
Topics: Adult; Alleles; Aspartic Acid; Female; Genotype; Glutamic Acid; Humans; Hypertension; India; Male; Middle Aged; Nitric Oxide Synthase Type III; Polymorphism, Genetic | 2008 |
Side-chain protonation and mobility in the sarcoplasmic reticulum Ca2+-ATPase: implications for proton countertransport and Ca2+ release.
Topics: Animals; Aspartic Acid; Biological Transport; Calcium; Glutamic Acid; Kinetics; Protons; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2007 |
Glutamate and aspartate levels in the nucleus accumbens during cocaine self-administration and extinction: a time course microdialysis study.
Topics: Animals; Aspartic Acid; Behavior, Animal; Cocaine; Conditioning, Operant; Dose-Response Relationship, Drug; Extinction, Psychological; Extracellular Fluid; Female; Glutamic Acid; Injections, Intravenous; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Inbred Lew; Self Administration; Time Factors | 2008 |
Umami compounds are a determinant of the flavor of potato (Solanum tuberosum L.).
Topics: Adenosine Monophosphate; Aspartic Acid; Glutamic Acid; Guanosine Monophosphate; Humans; Plant Tubers; Solanum tuberosum; Taste | 2007 |
Amino-acid levels in subretinal and vitreous fluid of patients with retinal detachment.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Aspartic Acid; Chromatography, High Pressure Liquid; Female; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Prospective Studies; Retina; Retinal Detachment; Scleral Buckling; Visual Acuity; Vitrectomy; Vitreous Body | 2008 |
Short-TE localised 1H MRS of the human brain at 3 T: quantification of the metabolite signals using two approaches to account for macromolecular signal contributions.
Topics: Adult; Aspartic Acid; Body Water; Brain; Choline; Creatine; Echo-Planar Imaging; Female; Glucose; Glutamic Acid; Humans; Inositol; Macromolecular Substances; Magnetic Resonance Spectroscopy; Male; Middle Aged; Research Design; Sensitivity and Specificity; Signal Processing, Computer-Assisted | 2008 |
Molecular analysis of the VSX1 gene in familial keratoconus.
Topics: Adult; Aspartic Acid; Eye Proteins; Female; Genetic Variation; Glutamic Acid; Homeodomain Proteins; Humans; Keratoconus; Male; Middle Aged; Pedigree; Polymorphism, Single Nucleotide | 2007 |
GABA transporter type 1 (GAT-1) uptake inhibition reduces stimulated aspartate and glutamate release in the dorsal spinal cord in vivo via different GABAergic mechanisms.
Topics: Analysis of Variance; Animals; Aspartic Acid; Bicuculline; Dose-Response Relationship, Drug; Drug Combinations; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Morpholines; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Oximes; Potassium Chloride; Rats; Rats, Wistar; Spinal Cord | 2007 |
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a.
Topics: Acid Sensing Ion Channels; Amino Acid Sequence; Amino Acid Substitution; Amino Acids; Animals; Aspartic Acid; Binding Sites; Calcium; Female; Glutamic Acid; Histidine; Hydrogen-Ion Concentration; Ion Channel Gating; Membrane Proteins; Models, Molecular; Molecular Sequence Data; Nerve Tissue Proteins; Oocytes; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Sequence Homology, Amino Acid; Sodium Channels; Structure-Activity Relationship; Xenopus laevis | 2008 |
Human deafness mutation E385D disrupts the mechanochemical coupling and subcellular targeting of myosin-1a.
Topics: Actin Cytoskeleton; Actins; Animals; Aspartic Acid; Deafness; Dictyostelium; Glutamic Acid; Green Fluorescent Proteins; Humans; Mechanotransduction, Cellular; Mutation; Myosin Heavy Chains; Myosin Type I; Myosin Type II; Protein Transport; Recombinant Fusion Proteins; Subcellular Fractions | 2008 |
Glutamine as a precursor for transmitter glutamate, aspartate and GABA in the cerebellum: a role for phosphate-activated glutaminase.
Topics: Animals; Aspartic Acid; Cerebellum; gamma-Aminobutyric Acid; Glutamic Acid; Glutaminase; Glutamine; Nerve Fibers; Neurotransmitter Agents; Rats; Rats, Wistar | 2008 |
Existence of an endogenous glutamate and aspartate transporter in Chinese hamster ovary cells.
Topics: Amino Acid Sequence; Amino Acid Transport System X-AG; Animals; Aspartic Acid; CHO Cells; Cricetinae; Cricetulus; Glutamic Acid; Humans; Molecular Sequence Data; Sequence Homology, Amino Acid; Species Specificity | 2007 |
Tertiary structure in 7.9 M guanidinium chloride--the role of Glu53 and Asp287 in Pyrococcus furiosus endo-beta-1,3-glucanase.
Topics: Anilino Naphthalenesulfonates; Aspartic Acid; Binding Sites; Calcium; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Stability; Escherichia coli; Fluorescent Dyes; Glucan Endo-1,3-beta-D-Glucosidase; Glutamic Acid; Guanidine; Kinetics; Models, Biological; Models, Molecular; Mutation; Protein Binding; Protein Denaturation; Protein Renaturation; Protein Structure, Tertiary; Pyrococcus furiosus; Thermodynamics; Titrimetry | 2007 |
Glu298Asp polymorphism of the eNOS gene is associated with coronary collateral development.
Topics: Aged; Alleles; Amino Acid Substitution; Aspartic Acid; Coronary Occlusion; Coronary Stenosis; Coronary Vessels; Diabetes Complications; Female; Glutamic Acid; Humans; Male; Middle Aged; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Regression Analysis | 2008 |
The effect of a Glu370Asp mutation in glutaryl-CoA dehydrogenase on proton transfer to the dienolate intermediate.
Topics: Acyl Coenzyme A; Amino Acid Substitution; Aspartic Acid; Chromatography, High Pressure Liquid; Crystallography; Glutamic Acid; Glutaryl-CoA Dehydrogenase; Kinetics; Mass Spectrometry; Mutagenesis, Site-Directed; Mutation; Protons; Substrate Specificity | 2007 |
Glutamate transporter blockade affects Ca(2+) responses in astrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Calcium Channels; Calcium Signaling; Cells, Cultured; Egtazic Acid; Extracellular Space; Fluorescent Dyes; Glutamic Acid; Microscopy, Fluorescence; Rats; Rats, Wistar | 2008 |
Preferential vulnerability of mesencephalic dopamine neurons to glutamate transporter dysfunction.
Topics: alpha-Synuclein; Analysis of Variance; Animals; Aspartic Acid; Cells, Cultured; Dicarboxylic Acids; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Mesencephalon; Neurons; Neurotransmitter Uptake Inhibitors; Phosphopyruvate Hydratase; Pregnancy; Pyrrolidines; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrosine 3-Monooxygenase | 2008 |
Brainstem amino acid neurotransmitters and ventilatory response to hypoxia in piglets.
Topics: Acid-Base Equilibrium; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Blood Pressure; Carbon Dioxide; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Heart Rate; Hypoxia; Microdialysis; Neurotransmitter Agents; Oxygen; Pulmonary Ventilation; Respiratory Center; Respiratory Mechanics; Solitary Nucleus; Swine; Taurine; Tidal Volume; Time Factors | 2008 |
Spinal release of the amino acids with a time course in a rat model of postoperative pain.
Topics: Animals; Aspartic Acid; Excitatory Amino Acids; Glutamic Acid; Glycine; Male; Microdialysis; Neurotransmitter Agents; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Spinal Cord | 2007 |
Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development.
Topics: Alanine; Alleles; Arginine; Arthritis, Rheumatoid; Aspartic Acid; Child; Cohort Studies; Epitopes; Fathers; Female; Genetic Predisposition to Disease; Glutamic Acid; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Male; Mothers; Pregnancy; Prospective Studies | 2007 |
A biochemical analysis of the activation of the Drosophila caspase DRONC.
Topics: Animals; Apoptosis; Aspartic Acid; Caspases; Drosophila; Drosophila Proteins; Enzyme Activation; Enzyme Precursors; Glutamic Acid; Inhibitor of Apoptosis Proteins; Mutation; Recombinant Proteins | 2008 |
Metabolic alterations in medication-free patients with bipolar disorder: a 3T CSF-corrected magnetic resonance spectroscopic imaging study.
Topics: Adolescent; Adult; Aspartic Acid; Basal Ganglia; Bipolar Disorder; Brain; Case-Control Studies; Caudate Nucleus; Corpus Striatum; Creatine; Cross-Sectional Studies; Dominance, Cerebral; Energy Metabolism; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Reference Values | 2008 |
Effects of altered corticosteroid milieu on rat hippocampal neurochemistry and structure--an in vivo magnetic resonance spectroscopy and imaging study.
Topics: Animals; Aspartic Acid; Atrophy; Choline; Creatine; Dexamethasone; Energy Metabolism; Glucocorticoids; Glutamic Acid; Hippocampus; Hydrocortisone; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Multivariate Analysis; Rats; Rats, Wistar | 2008 |
Association between Alzheimer's disease and the NOS3 gene Glu298Asp polymorphism in Chinese.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Asian People; Aspartic Acid; Female; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Humans; Nitric Oxide Synthase Type III; Polymorphism, Genetic | 2008 |
Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amino Acid Sequence; Aspartic Acid; Binding Sites; Binding, Competitive; Cell Line; Computer Simulation; Glutamic Acid; Humans; Inositol Phosphates; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Phenylephrine; Prazosin; Protein Structure, Tertiary; Radioligand Assay; Receptors, Adrenergic, alpha-1; Serine; Structure-Activity Relationship; Sulfonamides; Tamsulosin; Transfection; Tritium | 2008 |
DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra.
Topics: Animals; Aspartic Acid; Brain Infarction; Chromatography, High Pressure Liquid; Cyclopentanes; Dialysis; Disease Models, Animal; Drug Administration Routes; Fluorenes; Glutamic Acid; Indans; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Tetrazolium Salts | 2008 |
Glutamate spillover modulates GABAergic synaptic transmission in the rat midbrain periaqueductal grey via metabotropic glutamate receptors and endocannabinoid signaling.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Cannabinoid Receptor Modulators; Endocannabinoids; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mesencephalon; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction; Synaptic Transmission | 2008 |
Metabolic changes in the thalamus after spinal cord injury followed by proton MR spectroscopy.
Topics: Analysis of Variance; Animals; Aspartic Acid; Choline; Creatine; Glutamic Acid; Hindlimb; Hot Temperature; Inositol; Magnetic Resonance Spectroscopy; Male; Protons; Rats; Rats, Wistar; Spinal Cord Injuries; Thalamus | 2008 |
Identification and validation of eukaryotic aspartate and glutamate methylation in proteins.
Topics: Amino Acid Sequence; Aspartic Acid; Glutamic Acid; HeLa Cells; Humans; Methylation; Molecular Sequence Data; Proteins; Proteomics; Saccharomyces cerevisiae; Tandem Mass Spectrometry | 2008 |
Breast cancer-associated mutations in metalloprotease disintegrin ADAM12 interfere with the intracellular trafficking and processing of the protein.
Topics: ADAM Proteins; ADAM12 Protein; Animals; Aspartic Acid; Biotinylation; Blotting, Western; Breast Neoplasms; Cell Movement; Female; Fluorescent Antibody Technique; Glutamic Acid; Glycine; Histidine; Humans; Immunoprecipitation; Leucine; Membrane Proteins; Mice; Mutation; Phenylalanine | 2008 |
Environmental enrichment increases amphetamine-induced glutamate neurotransmission in the nucleus accumbens: a neurochemical study.
Topics: Amphetamine; Animals; Aspartic Acid; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Environment; Extracellular Fluid; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2008 |
Deferoxamine decreases the excitatory amino acid levels and improves the histological outcome in the hippocampus of neonatal rats after hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Aspartic Acid; Deferoxamine; Excitatory Amino Acids; Female; Glutamic Acid; Hippocampus; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Ischemia, Brain; Male; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar | 2008 |
Association of the Glu298Asp polymorphism of the eNOS Gene with ischemic heart disease in Japanese diabetic subjects.
Topics: Amino Acid Substitution; Aspartic Acid; Diabetic Angiopathies; DNA; Glutamic Acid; Glycated Hemoglobin; Humans; Japan; Myocardial Ischemia; Nitric Oxide Synthase Type III; Polymorphism, Restriction Fragment Length | 2008 |
One-step formation of oligopeptide-like molecules from Glu and Asp in hydrothermal environments.
Topics: Aspartic Acid; Chromatography, High Pressure Liquid; Environment; Evolution, Chemical; Glutamic Acid; Kinetics; Oligopeptides; Origin of Life; Temperature | 2008 |
Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder.
Topics: Adult; Analysis of Variance; Animals; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Case-Control Studies; Creatine; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Matched-Pair Analysis; Metabolomics; Middle Aged; Prefrontal Cortex; Rats; Rats, Inbred WKY; Reference Values | 2009 |
In vivo 1H magnetic resonance spectroscopy-derived metabolite variations between acute-on-chronic liver failure and acute liver failure.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Case-Control Studies; Choline; Chronic Disease; Creatine; Female; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Inositol; Liver Failure, Acute; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Young Adult | 2008 |
Protonation state of Glu142 differs in the green- and blue-absorbing variants of proteorhodopsin.
Topics: Aspartic Acid; Escherichia coli; Glutamic Acid; Hydrogen-Ion Concentration; Models, Molecular; Photochemistry; Protein Structure, Secondary; Protons; Rhodopsin; Rhodopsins, Microbial; Spectrophotometry; Spectroscopy, Fourier Transform Infrared | 2008 |
Identification and characterization of novel cell wall hydrolase CwlT: a two-domain autolysin exhibiting n-acetylmuramidase and DL-endopeptidase activities.
Topics: Amino Acid Sequence; Aspartic Acid; Bacillus subtilis; Binding Sites; Cell Wall; Endopeptidases; Glutamic Acid; Glycoside Hydrolases; Hydrolases; Mass Spectrometry; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Acetylmuramoyl-L-alanine Amidase; Sequence Homology, Amino Acid | 2008 |
Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAIDS.
Topics: AIDS Dementia Complex; Analysis of Variance; Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Inositol; Linear Models; Macaca mulatta; Magnetic Resonance Spectroscopy; Severity of Illness Index; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus | 2008 |
Regional apparent metabolite concentrations in young adult brain measured by (1)H MR spectroscopy at 3 Tesla.
Topics: Adult; Age Factors; Aspartic Acid; Brain Chemistry; Choline; Dipeptides; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male | 2008 |
Characterization of a Pseudomonas putida ABC transporter (AatJMQP) required for acidic amino acid uptake: biochemical properties and regulation by the Aau two-component system.
Topics: Aspartic Acid; ATP-Binding Cassette Transporters; Bacterial Proteins; Base Sequence; Binding Sites; DNA Footprinting; DNA-Binding Proteins; DNA, Bacterial; Electrophoretic Mobility Shift Assay; Gene Deletion; Gene Expression Regulation, Bacterial; Gene Order; Glutamic Acid; Models, Biological; Molecular Sequence Data; Operon; Promoter Regions, Genetic; Protein Binding; Pseudomonas putida; Signal Transduction; Substrate Specificity | 2008 |
Three-dimensional structures of L-asparaginase from Erwinia carotovora complexed with aspartate and glutamate.
Topics: Asparaginase; Aspartic Acid; Crystallography, X-Ray; Glutamic Acid; Models, Molecular; Pectobacterium carotovorum; Protein Conformation | 2008 |
(1)H-MRS profile in MRI positive- versus MRI negative patients with temporal lobe epilepsy.
Topics: Adult; Analysis of Variance; Aspartic Acid; Creatine; Electroencephalography; Epilepsy, Temporal Lobe; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Sclerosis | 2008 |
Self-contacts in Asx and Glx residues of high-resolution protein structures: role of local environment and tertiary interactions.
Topics: Amides; Animals; Aspartic Acid; Catalysis; Cellulase; Databases, Protein; Glutamic Acid; Glutathione Transferase; Histone Deacetylases; Humans; Hydrogen Bonding; Isoptera; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins; Surface Properties | 2008 |
Glutamate as a spectroscopic marker of hippocampal structural plasticity is elevated in long-term euthymic bipolar patients on chronic lithium therapy and correlates inversely with diurnal cortisol.
Topics: Adult; Aged; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Case-Control Studies; Choline; Circadian Rhythm; Creatine; Female; Glutamic Acid; Hippocampus; Humans; Hydrocortisone; Linear Models; Lithium Chloride; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuronal Plasticity; Saliva | 2009 |
Simultaneous observation of glutamate, gamma-aminobutyric acid, and glutamine in human brain at 4.7 T using localized two-dimensional constant-time correlation spectroscopy.
Topics: Aspartic Acid; Brain; Brain Chemistry; Creatine; Data Interpretation, Statistical; Energy Transfer; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Image Enhancement; Magnetic Resonance Spectroscopy; Magnetics; Phantoms, Imaging; Protons; Radio Waves; Sensitivity and Specificity; Signal Processing, Computer-Assisted | 2008 |
Experimental and theoretical studies of sodium cation complexes of the deamidation and dehydration products of asparagine, glutamine, aspartic acid, and glutamic acid.
Topics: Amides; Amino Acids; Asparagine; Aspartic Acid; Glutamic Acid; Glutamine; Kinetics; Models, Chemical; Sodium; Thermodynamics; Water | 2008 |
An adult with type 2 citrullinemia presenting in Europe.
Topics: Adult; Aspartic Acid; Biological Transport, Active; Citrullinemia; Europe; Fatal Outcome; Glutamic Acid; Humans; Hyperammonemia; Liver; Male; Membrane Transport Proteins; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Point Mutation; Sequence Analysis, DNA | 2008 |
Glutamate transporters of blood platelets as potential peripheral markers to analyze changes of glutamate transport activity in brain under altered gravity conditions.
Topics: Animals; Aspartic Acid; Biomarkers; Blood Platelets; Brain; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Gravity, Altered; Kinetics; Male; Rats; Rats, Wistar; Sodium; Synaptosomes | 2007 |
gamma-Glutamate and beta-hydroxyaspartate in proteins.
Topics: Adsorption; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Glutamic Acid; Humans; Membrane Lipids; Phospholipids; Proteins | 2008 |
[Neurotransmission mechanism of movement disorders in multiple sclerosis].
Topics: Adolescent; Adult; Aspartic Acid; Disease Progression; Female; Glutamic Acid; Humans; Male; Middle Aged; Motor Activity; Movement Disorders; Multiple Sclerosis; Neuromuscular Junction; Severity of Illness Index; Synaptic Transmission | 2007 |
Catalytic mechanism of inulinase from Arthrobacter sp. S37.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arthrobacter; Aspartic Acid; Bacterial Proteins; Binding Sites; Catalysis; Catalytic Domain; Conserved Sequence; Glutamic Acid; Glycoside Hydrolases; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Sequence Alignment | 2008 |
Post-translational modification of cellular proteins during Leishmania donovani differentiation.
Topics: Animals; Asparagine; Aspartic Acid; Cell Differentiation; Chromatography, Liquid; Glutamic Acid; Glycosylation; Histidine; Humans; Leishmania donovani; Macrophages; Mass Spectrometry; Phosphorylation; Protein Processing, Post-Translational; Proteomics | 2008 |
An amino acid at position 142 in nitrilase from Rhodococcus rhodochrous ATCC 33278 determines the substrate specificity for aliphatic and aromatic nitriles.
Topics: Amino Acid Sequence; Amino Acids; Aminohydrolases; Arginine; Asparagine; Aspartic Acid; Catalysis; Glutamic Acid; Kinetics; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Nitriles; Rhodococcus; Sequence Alignment; Substrate Specificity | 2008 |
Accelerated proton echo planar spectroscopic imaging (PEPSI) using GRAPPA with a 32-channel phased-array coil.
Topics: Aspartic Acid; Brain; Choline; Creatine; Feasibility Studies; Glutamic Acid; Glutamine; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Spectroscopy; Phantoms, Imaging; Protons | 2008 |
Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Amino Acid Sequence; Apolipoprotein E4; Aspartic Acid; Brain; Disease Progression; Female; Genotype; Glutamic Acid; Humans; Immunohistochemistry; Male; Molecular Weight; Neurofibrillary Tangles; Peptide Hydrolases; Predictive Value of Tests; Protein Structure, Tertiary; Proteomics; Severity of Illness Index; tau Proteins | 2008 |
Amino acid-dependent growth of Campylobacter jejuni: key roles for aspartase (AspA) under microaerobic and oxygen-limited conditions and identification of AspB (Cj0762), essential for growth on glutamate.
Topics: Aerobiosis; Amino Acids; Animals; Aspartate Aminotransferases; Aspartate Ammonia-Lyase; Aspartic Acid; Bacterial Proteins; Biosynthetic Pathways; Campylobacter Infections; Campylobacter jejuni; Chickens; Culture Media; Dicarboxylic Acid Transporters; Fumarates; Glutamic Acid; Humans; Kinetics; Mutation; Oxygen; Transcription, Genetic | 2008 |
Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis.
Topics: Alanine Racemase; Amino Acid Sequence; Aspartic Acid; Crystallography, X-Ray; Escherichia coli; Glutamic Acid; Kinetics; Models, Molecular; Molecular Sequence Data; Sequence Homology, Amino Acid; Substrate Specificity | 2008 |
A missense mutation causes aspartase deficiency in Yersinia pestis.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartate Ammonia-Lyase; Aspartic Acid; Circular Dichroism; Cloning, Molecular; Escherichia coli; Glutamic Acid; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation, Missense; Protein Conformation; Sequence Alignment; Yersinia pestis; Yersinia pseudotuberculosis | 2008 |
Structural features of glutamate-based lipidic materials for small interfering RNA delivery system.
Topics: Animals; Aspartic Acid; beta-Galactosidase; CHO Cells; Cricetinae; Cricetulus; Gene Transfer Techniques; Glutamic Acid; Green Fluorescent Proteins; Indicators and Reagents; Lipids; Particle Size; Quaternary Ammonium Compounds; RNA, Small Interfering | 2009 |
Anterior cingulate glutamate-glutamine levels predict symptom severity in women with obsessive-compulsive disorder.
Topics: Adult; Aspartic Acid; Biomarkers; Choline; Creatine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Obsessive-Compulsive Disorder; Predictive Value of Tests; Severity of Illness Index; Sex Factors | 2008 |
Extracellular levels of brain aspartate, glutamate and GABA during an inhibitory avoidance response in the rat.
Topics: Animals; Aspartic Acid; Avoidance Learning; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Male; Neural Inhibition; Rats; Rats, Wistar | 2008 |
Effects of amino acids on microcystin production of the Microcystis aeruginosa.
Topics: Alanine; Amino Acids; Arginine; Aspartic Acid; Biotechnology; Cyanobacteria; Glutamic Acid; Leucine; Marine Toxins; Microcystins; Microcystis; Microscopy, Electron, Scanning; Nitrogen; Time Factors | 2009 |
Reduced parietooccipital white matter glutamine measured by proton magnetic resonance spectroscopy in treated graves' disease patients.
Topics: Adult; Aspartic Acid; Choline; Dipeptides; Female; Glutamic Acid; Glutamine; Graves Disease; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Parietal Lobe; Prospective Studies | 2008 |
Isoflurane preconditioning reduces mouse microglial activation and injury induced by lipopolysaccharide and interferon-gamma.
Topics: Anesthetics, Inhalation; Animals; Aspartic Acid; Blotting, Western; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Glutamic Acid; Guanidines; Interferon-gamma; Isoflurane; Lipopolysaccharides; Mice; Microglia; Nitric Oxide Synthase Type II; Nitrites; Protein Kinase C; Tetrazolium Salts; Thiazoles | 2008 |
Synthesis, nano-scale assembly, and in vivo anti-thrombotic activity of novel short peptides containing L-Arg and L-Asp or L-Glu.
Topics: Animals; Arginine; Aspartic Acid; Aspirin; Circular Dichroism; Dose-Response Relationship, Drug; Fibrinolytic Agents; Glutamic Acid; Nanostructures; Oligopeptides; Particle Size; Platelet Aggregation Inhibitors; Rats; Thrombosis | 2008 |
The effect of epileptic seizures on proton MRS visible neurochemical concentrations.
Topics: Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Data Interpretation, Statistical; Dipeptides; Female; Glutamic Acid; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phosphocreatine; Protons; Seizures | 2008 |
Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats.
Topics: Animals; Aspartic Acid; Drugs, Chinese Herbal; Extracellular Fluid; Glutamic Acid; Glycine; Hippocampus; Male; Microdialysis; Nervous System Diseases; Phytotherapy; Potassium Chloride; Rats; Rats, Wistar; Synaptic Transmission; Taurine; Zinc | 2008 |
[Quantitation of glutamate in the brain by using MR proton spectroscopy at 1.5 T and 3 T].
Topics: Adult; Aspartic Acid; Brain; Brain Mapping; Cerebral Cortex; Dominance, Cerebral; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Image Processing, Computer-Assisted; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Phantoms, Imaging; Reference Values; Sensitivity and Specificity; Thalamus | 2008 |
Increase in excitatory amino acid concentration and transporters expression in osteoarthritic knees of anterior cruciate ligament transected rabbits.
Topics: Animals; Anterior Cruciate Ligament; Aspartic Acid; Clinical Protocols; Excitatory Amino Acids; Glutamic Acid; Immunohistochemistry; Injections, Intra-Articular; Knee Joint; Male; Membrane Transport Proteins; Microdialysis; Osteoarthritis, Knee; Rabbits; Range of Motion, Articular | 2008 |
A 1H magnetic resonance spectroscopy study in adults with obsessive compulsive disorder: relationship between metabolite concentrations and symptom severity.
Topics: Adult; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multivariate Analysis; Obsessive-Compulsive Disorder; Principal Component Analysis; Protons; Severity of Illness Index; Surveys and Questionnaires | 2008 |
Effects of tamoxifen on L-glutamate transporters of astrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Dose-Response Relationship, Drug; Estrogen Antagonists; Glutamic Acid; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Receptors, Estrogen; Tacrine; Tamoxifen | 2008 |
Quantal mEPSCs and residual glutamate: how horizontal cell responses are shaped at the photoreceptor ribbon synapse.
Topics: Alanine Transaminase; Ambystoma; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Light; Organ Culture Techniques; Patch-Clamp Techniques; Photic Stimulation; Photoreceptor Cells; Photoreceptor Cells, Vertebrate; Retinal Horizontal Cells; Synapses; Synaptic Transmission; Synaptic Vesicles; Vision, Ocular | 2008 |
An investigation into the protonation states of the C1 domain of cardiac myosin-binding protein C.
Topics: Aspartic Acid; Carrier Proteins; Crystallography, X-Ray; Glutamic Acid; Humans; Models, Molecular; Neutron Diffraction; Protein Structure, Tertiary; Protons; Recombinant Proteins; Static Electricity; Synchrotrons | 2008 |
Interaction of excitatory and depressant amino acids in the frog retina.
Topics: Action Potentials; Alanine; Animals; Anura; Aspartic Acid; Drug Interactions; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Retina; Retinal Ganglion Cells | 1968 |
Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex.
Topics: Animals; Aspartic Acid; Astrocytes; Blood Volume; Brain Mapping; Calcium; Calcium Signaling; Cerebrovascular Circulation; Ferrets; Fluorescent Dyes; Glutamic Acid; Male; Microscopy, Confocal; Neurons; Neurotransmitter Agents; Photic Stimulation; Synapses; Visual Cortex | 2008 |
Deamidation destabilizes and triggers aggregation of a lens protein, betaA3-crystallin.
Topics: Amino Acid Substitution; Aspartic Acid; beta-Crystallin A Chain; beta-Crystallin B Chain; Circular Dichroism; Dimerization; Dose-Response Relationship, Drug; Escherichia coli; Glutamic Acid; Hot Temperature; Humans; Lens, Crystalline; Models, Molecular; Molecular Weight; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Thermodynamics; Urea | 2008 |
Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania.
Topics: Acute Disease; Adolescent; Adult; Aspartic Acid; Bipolar Disorder; Case-Control Studies; Cerebral Cortex; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Matched-Pair Analysis; Neuroglia; Neurons; Neurotransmitter Agents; Occipital Lobe; Parietal Lobe; Pilot Projects; Reference Values; Schizophrenia; Synaptic Transmission; Young Adult | 2008 |
Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1.
Topics: Adolescent; Aggrecans; Aspartic Acid; Brain; Calcium; Case-Control Studies; Chelating Agents; Child; Child Development Disorders, Pervasive; Child, Preschool; Egtazic Acid; Electron Transport Complex IV; Family Health; Female; Gene Expression Regulation; Genotype; Glutamic Acid; Homeostasis; Humans; Linkage Disequilibrium; Male; Mitochondria; Neocortex; Oxidative Stress; Serotonin; Young Adult | 2010 |
[Study on main effectual ingredient content in fresh juice of Panax quinquefolium].
Topics: Amino Acids; Aspartic Acid; Fruit; Ginsenosides; Glutamic Acid; Iron; Manganese; Panax; Plants, Medicinal; Trace Elements | 2008 |
Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Encephalitis; Enzyme Inhibitors; Excitatory Amino Acids; Glutamic Acid; Isoenzymes; Microglia; NADPH Oxidase 4; NADPH Oxidases; Oxidants; Oxidative Stress; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Voltage-Dependent Anion Channels; Zymosan | 2008 |
Presynaptic mGlu1 and mGlu5 autoreceptors facilitate glutamate exocytosis from mouse cortical nerve endings.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agents; Exocytosis; Gene Expression; Glutamic Acid; Glycine; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Potassium Chloride; Presynaptic Terminals; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Synaptosomes; Syntaxin 1; Tritium; Vesicular Glutamate Transport Protein 1 | 2008 |
Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity.
Topics: Aspartic Acid; Calcium; Crystallography, X-Ray; Factor VIIa; Glutamic Acid; Humans; Hydrogen; Hydrogen Bonding; Models, Molecular; Mutation; Protein Binding; Protein Structure, Tertiary; Static Electricity; Thromboplastin; Time Factors | 2008 |
Proton MRS in twin pairs discordant for schizophrenia.
Topics: Aspartic Acid; Creatine; Female; Glutamic Acid; Glycerylphosphorylcholine; Hippocampus; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Phosphocreatine; Phosphorylcholine; Prefrontal Cortex; Protons; Schizophrenia; Twins, Dizygotic; Twins, Monozygotic | 2010 |
Development of a temperature gradient focusing method for in situ extraterrestrial biomarker analysis.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Aspartic Acid; Biomarkers; Countercurrent Distribution; Electrophoresis, Microchip; Extraterrestrial Environment; Glutamic Acid; Glycine; Life; Mars; Serine; Soil; Space Flight; Stereoisomerism; Temperature; Valine | 2008 |
GMP prevents excitotoxicity mediated by NMDA receptor activation but not by reversal activity of glutamate transporters in rat hippocampal slices.
Topics: Animals; Aspartic Acid; Brain Diseases, Metabolic; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine Monophosphate; Hippocampus; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Vesicular Glutamate Transport Proteins | 2008 |
1H/13C MR spectroscopic imaging of regionally specific metabolic alterations after experimental stroke.
Topics: Animals; Aspartic Acid; Brain; Carbon Isotopes; Glucose; Glutamic Acid; Glutamine; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Models, Animal; Neuroglia; Neurons; Neuropsychological Tests; Rats; Rats, Wistar; Stroke | 2008 |
Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel 2.
Topics: Amino Acid Substitution; Aspartic Acid; Calcium; Cations, Divalent; Cell Line; Glutamic Acid; Humans; Ion Transport; Magnesium; Mutation, Missense; Permeability; Sodium; TRPM Cation Channels | 2008 |
Identification of a vesicular aspartate transporter.
Topics: Adenosine Triphosphate; Amino Acid Transport Systems, Acidic; Animals; Aspartic Acid; Biological Transport; Cells, Cultured; Exocytosis; Glutamic Acid; Hippocampus; Humans; Mice; N-Acetylneuraminic Acid; Neurons; Organic Anion Transporters; Phylogeny; Rats; Rats, Wistar; Symporters | 2008 |
Regulation of Chk1 by its C-terminal domain.
Topics: Alleles; Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Checkpoint Kinase 1; Conserved Sequence; Enzyme Activation; G2 Phase; Genes, Suppressor; Glutamic Acid; Methyl Methanesulfonate; Molecular Sequence Data; Mutant Proteins; Mutation; Phenotype; Phosphorylation; Protein Kinases; Protein Structure, Tertiary; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Structure-Activity Relationship; Temperature | 2008 |
Neurotensin modulation of acetylcholine, GABA, and aspartate release from rat prefrontal cortex studied in vivo with microdialysis.
Topics: Acetylcholine; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Motor Activity; Neurotensin; Prefrontal Cortex; Pyrazoles; Quinolines; Rats; Rats, Wistar; Receptors, Neurotensin; Sodium Channel Blockers; Taurine; Tetrodotoxin | 2008 |
Comparison of nitrogen narcosis and helium pressure effects on striatal amino acids: a microdialysis study in rats.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Corpus Striatum; Glutamic Acid; Glutamine; Helium; Inert Gas Narcosis; Male; Microdialysis; Nitrogen; Pressure; Rats; Rats, Sprague-Dawley | 2009 |
MR-spectroscopic findings in juvenile-onset Huntington's disease.
Topics: Adolescent; Aspartic Acid; Brain Mapping; Child; Child, Preschool; Creatine; Female; Glutamic Acid; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Protons; Putamen; Trinucleotide Repeats; Young Adult | 2008 |
Identification of four novel types of in vitro protein modifications.
Topics: Algorithms; Amino Acid Sequence; Animals; Aspartic Acid; Cattle; Chromatography, High Pressure Liquid; Cysteine; Glutamic Acid; Glycerol; Lysine; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Protein Processing, Post-Translational; Proteins; Reproducibility of Results; Sequence Alignment; Serum Albumin, Bovine | 2008 |
Protective effect of aspartate and glutamate on cardiac mitochondrial function during myocardial infarction in experimental rats.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Enzyme Activation; Glutamic Acid; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Injections, Intraperitoneal; Injections, Subcutaneous; Isoproterenol; Lipid Peroxidation; Male; Mitochondria, Heart; Myocardial Infarction; Oxidation-Reduction; Rats; Rats, Wistar; Succinic Acid | 2008 |
Can cluster structure affect kinetic method measurements? The curious case of glutamic acid's gas-phase acidity.
Topics: 2-Aminoadipic Acid; Amino Acids; Aspartic Acid; Esterification; Gases; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Models, Molecular; Molecular Structure; Peptides; Spectrometry, Mass, Electrospray Ionization; Thermodynamics | 2008 |
Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Chromans; Enzyme Inhibitors; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamic Acid; Mitogen-Activated Protein Kinases; Oxidative Stress; Peptide Fragments; Protein Carbonylation; Rats; Rats, Wistar; Signal Transduction; Thiobarbituric Acid Reactive Substances; Tritium | 2008 |
Sensitive and selective detection of aspartic acid and glutamic acid based on polythiophene-gold nanoparticles composite.
Topics: Aspartic Acid; Glutamic Acid; Gold; Metal Nanoparticles; Microscopy, Electron, Transmission; Molecular Structure; Polymers; Reproducibility of Results; Sensitivity and Specificity; Solutions; Spectrophotometry; Thiophenes | 2008 |
A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2).
Topics: Animals; Aspartic Acid; Astrocytes; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Immunohistochemistry; Male; Mice; Mice, Knockout; Microscopy, Electron; Microscopy, Immunoelectron; Neuroglia; Presynaptic Terminals; Rats; Rats, Wistar; Substrate Specificity; Synaptosomes | 2008 |
Multiple protein domains mediate interaction between Bcl10 and MALT1.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Aspartic Acid; B-Cell CLL-Lymphoma 10 Protein; Caspases; Chickens; Glutamic Acid; Humans; Molecular Conformation; Molecular Sequence Data; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; Neoplasm Proteins; NF-kappa B; Point Mutation; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid | 2008 |
Molecular and structural characterization of HIV-1 subtype B Brazilian isolates with GWGR tetramer at the tip of the V3-loop.
Topics: Amino Acid Sequence; Aspartic Acid; Brazil; Evolution, Molecular; Glutamic Acid; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Models, Molecular; Peptide Fragments; Phylogeny; Protein Structure, Tertiary | 2008 |
Effect of safranal on extracellular hippocampal levels of glutamate and aspartate during kainic Acid treatment in anesthetized rats.
Topics: Anesthesia; Animals; Aspartic Acid; Cyclohexenes; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; Terpenes | 2008 |
An isocratic fluorescence HPLC assay for the monitoring of l-asparaginase activity and l-asparagine depletion in children receiving E. colil-asparaginase for the treatment of acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Stability; Escherichia coli Proteins; Fluorescence; Glutamic Acid; Glutamine; Homoserine; Humans; Least-Squares Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2009 |
Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population.
Topics: Aged; Asian People; Aspartic Acid; Case-Control Studies; Colorectal Neoplasms; DNA Glycosylases; DNA-(Apurinic or Apyrimidinic Site) Lyase; Female; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Glutamine; Histidine; Humans; Male; Middle Aged; Polymorphism, Genetic; Smoking | 2008 |
Interactions of mono- and divalent metal ions with aspartic and glutamic acid investigated with IR photodissociation spectroscopy and theory.
Topics: Aspartic Acid; Computer Simulation; Glutamic Acid; Ions; Metals, Alkali; Metals, Alkaline Earth; Models, Chemical; Spectrophotometry, Infrared | 2008 |
Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: correlates and predictors of treatment response.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Statistics, Nonparametric; Young Adult | 2009 |
[Effects of electroacupuncture on glutamate and aspartic acid contents in the dorsal root ganglion and spinal cord in rats with neuropathic pain].
Topics: Acupuncture Analgesia; Animals; Aspartic Acid; Electroacupuncture; Female; Ganglia, Spinal; Glutamic Acid; Humans; Male; Neuralgia; Neurotransmitter Agents; Pain Threshold; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Cord | 2008 |
Glutamate transporter-mediated glutamate secretion in the mammalian pineal gland.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cesium; Chlorides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exocytosis; Glutamic Acid; In Vitro Techniques; Kainic Acid; Macrolides; Magnesium; Male; Melatonin; Membrane Potentials; Pineal Gland; Potassium Chloride; Rats; Rats, Sprague-Dawley | 2008 |
Differential prepuberal handling modifies behaviour and excitatory amino acids in the forebrain of the Naples High-Excitability rats.
Topics: Animals; Aspartic Acid; Attention; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acids; Exploratory Behavior; Glutamic Acid; Handling, Psychological; Hippocampus; Hypothalamus; Maze Learning; Motor Activity; Prefrontal Cortex; Prosencephalon; Rats; Rats, Inbred Strains; Space Perception | 2009 |
Impaired expression of excitatory amino acid transporter 2 (EAAT2) and glutamate homeostasis in canine necrotizing meningoencephalitis.
Topics: Animals; Aspartic Acid; Astrocytes; Dog Diseases; Dogs; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Female; gamma-Aminobutyric Acid; Glutamic Acid; Leukoencephalitis, Acute Hemorrhagic; Male; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Taurine; Tumor Necrosis Factor-alpha | 2008 |
Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs.
Topics: Animals; Aspartic Acid; Diazonium Compounds; Dizocilpine Maleate; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Patch-Clamp Techniques; Pyridines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 2008 |
Evidence of reduced glutamate in the frontal lobe of HIV-seropositive patients.
Topics: Adult; Aspartic Acid; Case-Control Studies; Female; Frontal Lobe; Glutamic Acid; HIV Seropositivity; Humans; Magnetic Resonance Imaging; Male; Middle Aged | 2009 |
An automatic electrophysiological assay for the neuronal glutamate transporter mEAAC1.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Carboxylic Acids; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Electrophysiology; Glutamic Acid; Inhibitory Concentration 50; Ion Transport; Membrane Potentials; Mice; Oxazoles; Patch-Clamp Techniques; Potassium; Sodium; Transfection | 2009 |
Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents.
Topics: Adrenergic Agonists; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Brain; Catecholamines; Cells, Cultured; Citric Acid Cycle; Energy Metabolism; Enzyme Inhibitors; Glutamic Acid; Glycogen; Glycogen Phosphorylase; Glycogenolysis; Glycolysis; Mice; Norepinephrine | 2009 |
Effects of gabapentin and pregabalin on K+-evoked 3H-GABA and 3H-glutamate release from human neocortical synaptosomes.
Topics: Adolescent; Adult; Aged; Amines; Amino Acids, Cyclic; Anticonvulsants; Aspartic Acid; Calcium Channel Blockers; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Exocytosis; Female; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Infant; Isoleucine; Male; Middle Aged; Neocortex; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Oximes; Potassium; Pregabalin; Synaptosomes; Tacrolimus; Young Adult | 2009 |
Contralateral high or a combination of high- and low-frequency transcutaneous electrical nerve stimulation reduces mechanical allodynia and alters dorsal horn neurotransmitter content in neuropathic rats.
Topics: Acupuncture Points; Amino Acids; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamic Acid; Male; Neurotransmitter Agents; Pain; Pain Management; Pain Measurement; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Skin; Spinal Cord; Transcutaneous Electric Nerve Stimulation | 2009 |
Neurochemical changes in a mouse model of Rett syndrome: changes over time and in response to perinatal choline nutritional supplementation.
Topics: Age Factors; Animals; Animals, Newborn; Aspartic Acid; Brain; Choline; Creatine; Dietary Supplements; Disease Models, Animal; DNA-Binding Proteins; Glutamic Acid; Glutamine; Histone Deacetylases; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Nootropic Agents; Rett Syndrome; Spectrum Analysis | 2009 |
Brain metabolism differs in Alzheimer's disease and Parkinson's disease dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Case-Control Studies; Choline; Creatine; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Mental Status Schedule; Middle Aged; Nootropic Agents; Parkinson Disease | 2008 |
Development and application of a liquid chromatography/tandem mass spectrometric assay for measurement of N-acetylaspartate, N-acetylaspartylglutamate and glutamate in brain slice superfusates and tissue extracts.
Topics: Animals; Aspartic Acid; Brain Chemistry; Chromatography, High Pressure Liquid; Dipeptides; Glutamic Acid; Rats; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2008 |
Analyzing the catalytic role of Asp97 in the methionine aminopeptidase from Escherichia coli.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Aminopeptidases; Asparagine; Aspartic Acid; Catalysis; Catalytic Domain; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Glycine; Kinetics; Methionine; Methionyl Aminopeptidases; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Recombinant Proteins; Sequence Alignment; Substrate Specificity | 2008 |
RANTES modulates the release of glutamate in human neocortex.
Topics: Adult; Aged; Analysis of Variance; Animals; Aspartic Acid; Calcium; Chemokine CCL5; D-Aspartic Acid; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glutamic Acid; Humans; In Vitro Techniques; Macrocyclic Compounds; Male; Mice; Middle Aged; Neocortex; Oxazoles; Receptors, CCR; Synaptosomes; Time Factors; Tritium; Young Adult | 2008 |
Effect of infrared laser irradiation on amino acid neurotransmitters in an epileptic animal model induced by pilocarpine.
Topics: Alanine Transaminase; Amino Acids; Analysis of Variance; Animals; Aspartate Aminotransferases; Aspartic Acid; Cerebral Cortex; Chromatography, High Pressure Liquid; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Lasers, Semiconductor; Male; Models, Animal; Neurotransmitter Agents; Pilocarpine; Rats; Taurine | 2009 |
Excitatory amino acids in the forebrain of the Naples high-excitability rats: neurochemical and behavioural effects of subchronic D-aspartate and its diethyl ester prodrug.
Topics: Animals; Aspartic Acid; Attention; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Emotions; Excitatory Amino Acids; Exploratory Behavior; Glutamic Acid; Hippocampus; Hypothalamus; Injections, Subcutaneous; Maze Learning; Motor Activity; Prefrontal Cortex; Prodrugs; Prosencephalon; Rats; Rats, Inbred Strains; Space Perception; Treatment Outcome | 2009 |
The role of amino acids in the long-distance transport of La and Y in the xylem sap of tomato.
Topics: Amino Acids; Aspartic Acid; Biological Transport; Chromatography, High Pressure Liquid; Glutamic Acid; Histidine; Lanthanum; Solanum lycopersicum; Tryptophan; Xylem; Yttrium | 2009 |
Ammonium-evoked alterations in intracellular sodium and pH reduce glial glutamate transport activity.
Topics: Aging; Animals; Aspartic Acid; Astrocytes; Biological Transport; Bumetanide; Cells, Cultured; Central Nervous System Agents; D-Aspartic Acid; Glutamic Acid; Hippocampus; Hydrogen-Ion Concentration; Immunohistochemistry; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Sodium; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2 | 2009 |
Glutamate receptors modulate sodium-dependent and calcium-independent vitamin C bidirectional transport in cultured avian retinal cells.
Topics: Animals; Animals, Newborn; Ascorbic Acid; Aspartic Acid; Biological Transport; Calcium; Chelating Agents; Chick Embryo; Cytoskeletal Proteins; Egtazic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Neurons; Organic Anion Transporters, Sodium-Dependent; Rats; Receptors, Glutamate; Retina; Sodium; Sodium-Coupled Vitamin C Transporters; Symporters; Tissue Culture Techniques; Tritium | 2009 |
Role of glutamate transporters in corticostriatal synaptic transmission.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biophysics; Cerebral Cortex; Corpus Striatum; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Green Fluorescent Proteins; In Vitro Techniques; Male; Neural Pathways; Neurons; Patch-Clamp Techniques; Rats; Rats, Inbred Lew; Synapses; Synaptic Transmission; Transduction, Genetic | 2009 |
Elevated forebrain excitatory L-glutamate, L-aspartate and D-aspartate in the Naples high-excitability rats.
Topics: Animals; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Exploratory Behavior; Glutamic Acid; Hippocampus; Hypothalamus; Maze Learning; Prefrontal Cortex; Prosencephalon; Rats; Rats, Inbred Strains; Space Perception | 2009 |
Metabolite changes and gender differences in schizophrenia using 3-Tesla proton magnetic resonance spectroscopy (1H-MRS).
Topics: Adult; Analysis of Variance; Aspartic Acid; Basal Ganglia; Choline; Creatine; Female; Glutamic Acid; Gyrus Cinguli; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Schizophrenia; Sex Characteristics; Young Adult | 2009 |
Neurochemical alterations in adolescent bipolar depression: a proton magnetic resonance spectroscopy pilot study of the prefrontal cortex.
Topics: Adolescent; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Aspartic Acid; Bipolar Disorder; Brain Chemistry; Child; Choline; Creatine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Pilot Projects; Prefrontal Cortex | 2008 |
Insulin-dependent regulation of GLAST/EAAT1 in Bergmann glial cells.
Topics: Animals; Aspartic Acid; Binding, Competitive; Cell Membrane; Cells, Cultured; Cerebellar Cortex; Chick Embryo; Dose-Response Relationship, Drug; Down-Regulation; Excitatory Amino Acid Transporter 1; Glucose; Glutamic Acid; Insulin; Neuroglia; Promoter Regions, Genetic; Receptor Protein-Tyrosine Kinases; Time Factors; Transcriptional Activation | 2009 |
Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons.
Topics: Analysis of Variance; Animals; Aspartic Acid; Cation Transport Proteins; Deferoxamine; Ferritins; Glutamic Acid; Immunoblotting; Immunohistochemistry; In Vitro Techniques; Iron; Iron Chelating Agents; L-Lactate Dehydrogenase; Lipid Peroxidation; Motor Neurons; Nerve Degeneration; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Transferrin; Spinal Cord | 2009 |
Fabrication of polymer-platinum(II) complex nanomicelle from mPEG-g-alpha,beta-poly [(N-amino acidyl)-DL-aspartamide] and cis-dichlorodiammine platinum(II) and its cytotoxicity.
Topics: Aspartic Acid; Cell Line, Tumor; Cell Survival; Cisplatin; Drug Delivery Systems; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Micelles; Models, Chemical; Peptides; Polyethylene Glycols; Polymers; Spectroscopy, Fourier Transform Infrared | 2009 |
Fast isotopic exchange between mitochondria and cytosol in brain revealed by relayed 13C magnetization transfer spectroscopy.
Topics: Animals; Aspartic Acid; Brain; Carbon Isotopes; Citric Acid Cycle; Cytosol; Glutamic Acid; Ketoglutaric Acids; Kinetics; Magnetic Resonance Spectroscopy; Mitochondria; Oxaloacetic Acid; Rats; Rats, Sprague-Dawley | 2009 |
Gray matter metabolism in acute and chronic hydrocephalus.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Mapping; Creatine; Disease Models, Animal; Glutamic Acid; Hydrocephalus; Image Processing, Computer-Assisted; Inositol; Kaolin; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Time Factors; Tritium | 2009 |
A summary of the measured pK values of the ionizable groups in folded proteins.
Topics: Amino Acid Sequence; Amino Acids; Aspartic Acid; Glutamic Acid; Histidine; Hydrogen-Ion Concentration; Isoelectric Point; Nuclear Magnetic Resonance, Biomolecular; Protein Folding; Protein Structure, Tertiary; Proteins; Titrimetry | 2009 |
Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS.
Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Choline; Creatine; Energy Metabolism; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Female; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Parietal Lobe; Reference Values; Valproic Acid; Young Adult | 2009 |
Brain metabolism in Rett syndrome: age, clinical, and genotype correlations.
Topics: Adolescent; Aging; Analysis of Variance; Aspartic Acid; Case-Control Studies; Child; Child, Preschool; Creatine; Female; Frontal Lobe; Genotype; Glutamic Acid; Glutamine; Humans; Infant; Inositol; Magnetic Resonance Spectroscopy; Methyl-CpG-Binding Protein 2; Mutation; Protons; Rett Syndrome; Severity of Illness Index | 2009 |
In vivo quantification of intracerebral GABA by single-voxel (1)H-MRS-How reproducible are the results?
Topics: Adult; Algorithms; Analysis of Variance; Aspartic Acid; Brain; Brain Chemistry; Creatine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Reproducibility of Results | 2010 |
Glutamate transporters prevent excessive activation of NMDA receptors and extrasynaptic glutamate spillover in the spinal dorsal horn.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Bicuculline; Dose-Response Relationship, Drug; Drug Combinations; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Male; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2009 |
Magnetic resonance spectroscopy reveals an epileptic network in juvenile myoclonic epilepsy.
Topics: Adult; Analysis of Variance; Anticonvulsants; Aspartic Acid; Brain; Brain Chemistry; Case-Control Studies; Creatine; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Myoclonic Epilepsy, Juvenile; Neural Pathways; Protons; Young Adult | 2009 |
Cultured astrocytes derived from corpus callosum or cortical grey matter show distinct glutamate handling properties.
Topics: Actins; Amino Acid Transport Systems; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Calcium; Cell Size; Cells, Cultured; Cerebral Cortex; Corpus Callosum; Cricetinae; Cricetulus; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Glutamic Acid; Intermediate Filament Proteins; Nerve Tissue Proteins; Nestin; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Transfection; Vimentin | 2009 |
Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain.
Topics: Animals; Aspartic Acid; Cerebrovascular Circulation; Corpus Striatum; Glucose; Glutamic Acid; Glutamine; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Kinetics; Lactic Acid; Magnetic Resonance Spectroscopy; Metabolism; Mice | 2009 |
Functional characterization and in silico docking of full and partial GluK2 kainate receptor agonists.
Topics: Aspartic Acid; Binding Sites; Cell Line; Concanavalin A; GluK2 Kainate Receptor; Glutamic Acid; Humans; Protein Conformation; Receptors, Kainic Acid; Serine; Stereoisomerism | 2009 |
Effects of chronic noise exposure on spatial learning and memory of rats in relation to neurotransmitters and NMDAR2B alteration in the hippocampus.
Topics: Amino Acids; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Learning; Male; Maze Learning; Memory; Neurotransmitter Agents; Nissl Bodies; Noise; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2009 |
Metabolic changes in the rat brain after a photochemical lesion treated by stem cell transplantation assessed by 1H MRS.
Topics: Animals; Aspartic Acid; Brain; Femur; Ferrocyanides; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats; Rats, Wistar; Time Factors | 2009 |
Elevated metabolites within dorsolateral prefrontal cortex in rapid cycling bipolar disorder.
Topics: Adult; Aspartic Acid; Biomarkers; Bipolar Disorder; Brain; Choline; Creatine; Female; Functional Laterality; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex | 2009 |
[Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain].
Topics: Acute Disease; Amino Acids; Analgesics, Opioid; Animals; Arginine; Aspartic Acid; Cerebral Cortex; Disinfectants; Formaldehyde; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Male; Microdialysis; Morphine; Pain; Rats; Rats, Wistar | 2008 |
Gas-phase IR spectroscopy of deprotonated amino acids.
Topics: Amino Acids; Anions; Aspartic Acid; Cysteine; Gases; Glutamic Acid; Phenylalanine; Protons; Serine; Spectrophotometry; Spectrophotometry, Infrared; Tyrosine | 2009 |
Characterization of salt bridges to lysines in the protein G B1 domain.
Topics: Aspartic Acid; Bacterial Proteins; Deuterium; Escherichia coli; Glutamic Acid; Hydrogen-Ion Concentration; Lysine; Nerve Tissue Proteins; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Tertiary; Quantum Theory; Salts; Streptococcus | 2009 |
Blockade of glutamate transporters facilitates cerebellar synaptic long-term depression.
Topics: Animals; Aspartic Acid; Cerebellum; D-Aspartic Acid; Electric Stimulation; Excitatory Amino Acid Transporter 4; Glutamic Acid; In Vitro Techniques; Long-Term Synaptic Depression; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Synapses | 2009 |
Four-electron reduction of dioxygen by a multicopper oxidase, CueO, and roles of Asp112 and Glu506 located adjacent to the trinuclear copper center.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Binding Sites; Circular Dichroism; Copper; Electron Spin Resonance Spectroscopy; Electrons; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Molecular Sequence Data; Mutant Proteins; Oxidation-Reduction; Oxidoreductases; Oxygen; Recombinant Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship | 2009 |
Allosteric and binding properties of Asp1-Glu382 truncated recombinant human serum albumin--an optical and NMR spectroscopic investigation.
Topics: Allosteric Site; Aspartic Acid; Binding Sites; Circular Dichroism; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Protein Conformation; Recombinant Proteins; Serum Albumin | 2009 |
Brain levels of GABA, glutamate and aspartate in sociable, aggressive and timid mice: an in vivo microdialysis study.
Topics: Aggression; Animals; Aspartic Acid; Behavior, Animal; Brain; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Microchemistry; Microdialysis; Models, Biological; Shyness; Social Behavior; Social Desirability | 2009 |
Hippocampal metabolic abnormalities at first onset and with recurrent episodes of a major depressive disorder: a proton magnetic resonance spectroscopy study.
Topics: Adult; Analysis of Variance; Aspartic Acid; Choline; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Organ Size; Protons; Recurrence | 2009 |
NMDA receptors mediate an early up-regulation of brain-derived neurotrophic factor expression in substantia nigra in a rat model of presymptomatic Parkinson's disease.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain-Derived Neurotrophic Factor; Cell Count; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Functional Laterality; Glutamic Acid; Male; Microdialysis; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Up-Regulation | 2009 |
Vesicular glutamate filling and AMPA receptor occupancy at the calyx of Held synapse of immature rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Benzothiadiazines; Brain Stem; Excitatory Postsynaptic Potentials; Glutamic Acid; Kynurenic Acid; Patch-Clamp Techniques; Presynaptic Terminals; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Vesicles; Temperature; Tetrodotoxin | 2009 |
Neurochemical effects of theta burst stimulation as assessed by magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Mapping; Electric Stimulation; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Motor Cortex; Neural Inhibition; Statistics, Nonparametric; Theta Rhythm; Transcranial Magnetic Stimulation; Young Adult | 2009 |
Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia.
Topics: Aging; Alanine; Animals; Aspartic Acid; Brain Ischemia; Brain Stem; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Male; Mice; Potassium; Serine; Taurine; Threonine | 2009 |
Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils.
Topics: Amyloid; Amyloid beta-Peptides; Amyloid Neuropathies, Familial; Aspartic Acid; Benzothiazoles; Glutamic Acid; Humans; Kinetics; Leucine; Lysine; Microscopy, Electron, Transmission; Models, Molecular; Mutation, Missense; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Phenylalanine; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles; X-Ray Diffraction | 2009 |
The importance of myocardial amino acids during ischemia and reperfusion in dilated left ventricle of patients with degenerative mitral valve disease.
Topics: Alanine; Amino Acids; Aspartic Acid; Dilatation, Pathologic; Female; Glutamic Acid; Glutamine; Heart Ventricles; Humans; Male; Middle Aged; Mitral Valve Insufficiency; Myocardial Reperfusion Injury; Myocardium; Taurine | 2009 |
Functional characterization of a Na+-dependent aspartate transporter from Pyrococcus horikoshii.
Topics: Amino Acid Transport Systems; Amino Acids; Aspartic Acid; Biological Transport; Cells, Cultured; Excitatory Amino Acid Transporter 1; Glutamic Acid; Hydrogen; Kinetics; Liposomes; Potassium; Pyrococcus horikoshii; Sodium; Substrate Specificity | 2009 |
The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes.
Topics: Action Potentials; Animals; Aspartic Acid; Calcium; Canavan Disease; Cerebellum; Dipeptides; Evoked Potentials; Glutamic Acid; Hydrolysis; Oligodendroglia; Patch-Clamp Techniques; Pelizaeus-Merzbacher Disease; Rats; Receptors, N-Methyl-D-Aspartate; Tissue Culture Techniques | 2009 |
Increased choline-containing compounds in the orbitofrontal cortex and hippocampus in euthymic patients with bipolar disorder: a proton magnetic resonance spectroscopy study.
Topics: Adult; Analysis of Variance; Aspartic Acid; Bipolar Disorder; Case-Control Studies; Choline; Female; Frontal Lobe; Functional Laterality; Glutamic Acid; Glutamine; Glycerylphosphorylcholine; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phosphorylcholine; Psychiatric Status Rating Scales; Severity of Illness Index | 2009 |
Functional significance of brain glycogen in sustaining glutamatergic neurotransmission.
Topics: Animals; Arabinose; Aspartic Acid; Astrocytes; Brain Chemistry; Cells, Cultured; Cerebellum; Coculture Techniques; Data Interpretation, Statistical; Energy Metabolism; Glutamic Acid; Glycogen; Glycolysis; Imino Furanoses; Indoles; Lactic Acid; Mice; Monocarboxylic Acid Transporters; Neurons; Phenylbutyrates; Sugar Alcohols; Synaptic Transmission | 2009 |
Delayed cerebral oxidative glucose metabolism after traumatic brain injury in young rats.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Edema; Brain Injuries; Glucose; Glutamic Acid; Glutamine; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Nerve Tissue Proteins; Neurotransmitter Agents; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 2009 |
Changes in MRS neuronal markers and T cell phenotypes observed during early HIV infection.
Topics: Adult; AIDS Dementia Complex; Aspartic Acid; Biomarkers; Brain; CD4-CD8 Ratio; Disease Progression; Early Diagnosis; Frontal Lobe; Glutamic Acid; HIV Seropositivity; Humans; Immunophenotyping; Magnetic Resonance Spectroscopy; Middle Aged; Neurons; T-Lymphocytes | 2009 |
Differentiating attention-deficit/hyperactivity disorder inattentive and combined types: a (1)H-magnetic resonance spectroscopy study of fronto-striato-thalamic regions.
Topics: Adolescent; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Choline; Corpus Striatum; Creatine; Diagnosis, Differential; Energy Metabolism; Female; Frontal Lobe; Functional Laterality; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Prosencephalon; Pulvinar; Putamen; Radionuclide Imaging; Thalamus; Young Adult | 2009 |
Are personality traits of juvenile myoclonic epilepsy related to frontal lobe dysfunctions? A proton MRS study.
Topics: Adolescent; Adult; Aspartic Acid; Brain Diseases; Creatine; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Myoclonic Epilepsy, Juvenile; Personality; Personality Disorders; Personality Inventory; Protons; Psychiatric Status Rating Scales; Retrospective Studies; Young Adult | 2009 |
Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Cell Death; Cells, Cultured; Competitive Bidding; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamic Acid; Neurons; Neuroprotective Agents; PC12 Cells; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tetrazolium Salts; Thiamine Deficiency; Thiazoles | 2009 |
Synaptic and extrasynaptic factors governing glutamatergic retinal waves.
Topics: Amino Acid Transport Systems, Acidic; Animals; Animals, Newborn; Aspartic Acid; Calcium; Dihydro-beta-Erythroidine; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; N-Methylaspartate; Neural Inhibition; Nicotinic Antagonists; Patch-Clamp Techniques; Pyridazines; Quinoxalines; Retinal Ganglion Cells; Synapses; Synaptic Transmission; Time Factors; Valine; Vesicular Glutamate Transport Protein 1 | 2009 |
Endothelial nitric oxide synthase gene polymorphisms are not associated with recurrent aphthous stomatitis.
Topics: Adult; Aspartic Acid; Behcet Syndrome; Case-Control Studies; Cohort Studies; Cytosine; Exons; Female; Gene Frequency; Genotype; Glutamic Acid; Guanine; Humans; INDEL Mutation; Introns; Linkage Disequilibrium; Male; Mutation, Missense; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Recurrence; Stomatitis, Aphthous; Tandem Repeat Sequences; Thymine; White People | 2009 |
The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression.
Topics: Adult; Arousal; Aspartic Acid; Blood Glucose; Corpus Callosum; Depressive Disorder, Major; Dominance, Cerebral; Emotions; Energy Metabolism; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurons; Oxygen Consumption; Synaptic Transmission | 2009 |
Characterization of chronic glutamate-mediated motor neuron toxicity in organotypic spinal cord culture prepared from ALS model mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Caspase 12; Cell Death; Cell Survival; Disease Models, Animal; Enzyme Activation; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Mice; Mice, Transgenic; Motor Neurons; Organ Culture Techniques; Spinal Cord; Superoxide Dismutase | 2009 |
Increased glutamate and decreased glycine release in the rostral ventromedial medulla during induction of a pre-clinical model of chronic widespread muscle pain.
Topics: Acids; Analysis of Variance; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Disease Models, Animal; Glutamic Acid; Glycine; Male; Medulla Oblongata; Microdialysis; Muscle, Skeletal; Pain; Rats; Rats, Sprague-Dawley; Sensory System Agents; Sodium Chloride | 2009 |
Relationship between hemorheology and Glu(298)Asp polymorphism of endothelial nitric oxide synthase gene in patients with coronary artery disease.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Amino Acid Substitution; Aspartic Acid; Case-Control Studies; Coronary Artery Disease; Electrophoresis, Agar Gel; Erythrocyte Aggregation; Female; Gene Frequency; Genotype; Glutamic Acid; Hemorheology; Humans; Male; Middle Aged; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide | 2010 |
Production of immunoaffinity membranes for direct analysis of antigen after antibody separation and blotting under non-denaturing conditions.
Topics: Antibodies; Antigen-Antibody Reactions; Antigens; Aspartic Acid; Electrophoresis, Gel, Two-Dimensional; Glutamic Acid; Humans; Immunosorbent Techniques; Membranes, Artificial; Polyvinyls; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transferrin | 2009 |
Effective amino acid composition of seaweeds inducing food preference behaviors in Aplysia kurodai.
Topics: Amino Acids; Animals; Aplysia; Asparagine; Aspartic Acid; Eating; Food Preferences; Glutamic Acid; Glutamine; Jaw; Phaeophyceae; Phenylalanine; Rhodophyta; Taste; Taurine; Ulva | 2009 |
Hyponatremia is a risk factor of hepatic encephalopathy in patients with cirrhosis: a prospective study with time-dependent analysis.
Topics: Adult; Aged; Aspartic Acid; Bilirubin; Brain Chemistry; Creatine; Creatinine; Female; Follow-Up Studies; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Hyponatremia; Liver Cirrhosis; Magnetic Resonance Spectroscopy; Male; Middle Aged; Parietal Lobe; Prognosis; Prospective Studies; Risk Factors; Sodium; Time Factors | 2009 |
Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons.
Topics: 3-Hydroxybutyric Acid; Animals; Aspartic Acid; Brain Chemistry; Cells, Cultured; Cerebellum; Cytosol; Energy Metabolism; Glucose; Glutamic Acid; Ketone Bodies; Malate Dehydrogenase; Mice; NAD; Neurons; Neurotransmitter Agents; Subcellular Fractions; Synaptic Transmission | 2009 |
Comparison of effects of endogenous and exogenous excitatory amino acids on Retzius nerve cells of the leech.
Topics: Amino Acids; Amino Acids, Diamino; Animals; Aspartic Acid; Glutamic Acid; In Vitro Techniques; Leeches; Membrane Potentials; Neurons; Neurotoxins | 2009 |
Quantitative analysis of the expression of the glutamate-aspartate transporter and identification of functional glutamate uptake reveal a role for cochlear fibrocytes in glutamate homeostasis.
Topics: Animals; Aspartic Acid; Cochlea; Excitatory Amino Acid Transporter 1; Fibroblasts; Glutamic Acid; Guinea Pigs; Homeostasis; Immunohistochemistry; In Vitro Techniques; Mice; Patch-Clamp Techniques; Rats | 2009 |
The effect of CRF and alpha-helical CRF((9-41)) on rat fear responses and amino acids release in the central nucleus of the amygdala.
Topics: Amino Acids; Amygdala; Animals; Anxiety; Aspartic Acid; Conditioning, Classical; Corticotropin-Releasing Hormone; Fear; Freezing Reaction, Cataleptic; gamma-Aminobutyric Acid; Glutamic Acid; Male; Peptide Fragments; Rats; Rats, Wistar; Stress, Psychological; Time Factors | 2009 |
Proton-transfer reactions in reaction center of photosynthetic bacteria Rhodobacter sphaeroides.
Topics: Aspartic Acid; Electron Transport; Glutamic Acid; Models, Chemical; Models, Molecular; Photosynthetic Reaction Center Complex Proteins; Protein Conformation; Protons; Quantum Theory; Rhodobacter sphaeroides; Thermodynamics | 2009 |
Differential contributions of Glu96, Asp102 and Asp111 to coagulation factor V/Va metal ion binding and subunit stability.
Topics: Aspartic Acid; Binding Sites; Calcium; Copper; Factor V; Factor Va; Glutamic Acid; Humans; Protein Stability; Protein Subunits | 2009 |
Axons and astrocytes release ATP and glutamate to evoke calcium signals in NG2-glia.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Antigens; Aspartic Acid; Astrocytes; Axons; Calcium; Calcium Signaling; Cerebral Cortex; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Green Fluorescent Proteins; In Vitro Techniques; Luminescent Proteins; Male; Mice; Mice, Transgenic; Optic Nerve; Pericytes; Physical Stimulation; Platelet Aggregation Inhibitors; Proteoglycans | 2010 |
Molecular determinants of the pKa values of Asp and Glu residues in staphylococcal nuclease.
Topics: Aspartic Acid; Calibration; Crystallography, X-Ray; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Micrococcal Nuclease; Models, Molecular; Molecular Conformation; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Static Electricity | 2009 |
Regulation of glutamate transport in developing rat oligodendrocytes.
Topics: Animals; Animals, Newborn; Aspartic Acid; Benzodiazepines; Bicuculline; Brain; Cells, Cultured; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Female; Fibroblast Growth Factors; GABA Antagonists; Gangliosides; Gene Expression Regulation, Developmental; Glutamic Acid; Kainic Acid; Membrane Potentials; Neurons; O Antigens; Oligodendroglia; Patch-Clamp Techniques; Platelet-Derived Growth Factor; Pregnancy; Quinoxalines; Rats; Rats, Long-Evans; Sodium Channel Blockers; Tetrodotoxin; Tritium | 2009 |
Using amino-nitrogen pools and fluxes to identify contributions of understory Acacia spp. to overstory Eucalyptus regnans and stand nitrogen uptake in temperate Australia.
Topics: Acacia; Amino Acids; Aspartic Acid; Biological Transport; Climate; Ecosystem; Eucalyptus; Glutamic Acid; Nitrogen; Phloem; Plant Leaves; Plant Structures; Trees; Xylem | 2009 |
Structural adaptability of zinc binding sites: different structures in partially, fully, and heavy-metal loaded states.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Cysteine; Glutamic Acid; Histidine; Metalloproteins; Molecular Sequence Data; Molecular Structure; Zinc; Zinc Fingers | 2009 |
Glutamate transporter coupling to Na,K-ATPase.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Blotting, Western; Cell Culture Techniques; Cerebellum; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunohistochemistry; Rats; Rats, Sprague-Dawley; Rubidium; Sodium-Potassium-Exchanging ATPase; Synaptosomes | 2009 |
MR spectroscopic evaluation of N-acetylaspartate's T2 relaxation time and concentration corroborates white matter abnormalities in schizophrenia.
Topics: Adult; Analysis of Variance; Aspartic Acid; Creatine; Dipeptides; Female; Frontal Lobe; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Nerve Fibers, Myelinated; Phosphocreatine; Protons; Schizophrenia; Water | 2009 |
Role of intramembrane polar residues in the YgfO xanthine permease: HIS-31 and ASN-93 are crucial for affinity and specificity, and ASP-304 and GLU-272 are irreplaceable.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Escherichia coli K12; Escherichia coli Proteins; Evolution, Molecular; Glutamic Acid; Histidine; Membrane Transport Proteins; Models, Biological; Mutation, Missense; Nucleobase Transport Proteins; Protein Structure, Secondary; Substrate Specificity; Xanthine | 2009 |
The effect of the side chain length of Asp and Glu on coordination structure of Cu(2+) in a de novo designed protein.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Chelating Agents; Copper; Electron Spin Resonance Spectroscopy; Glutamic Acid; Metalloproteins; Models, Molecular; Protein Engineering; Protein Structure, Secondary; Recombinant Fusion Proteins | 2009 |
Effect of exercise on glutamine metabolism in macrophages of trained rats.
Topics: Analysis of Variance; Animals; Aspartic Acid; Exercise Test; Fatigue; Glutamic Acid; Glutamine; Hydrogen Peroxide; Macrophages, Peritoneal; Phagocytosis; Physical Conditioning, Animal; Rats; Rats, Wistar; Rest; Swimming | 2009 |
Neurochemical changes in welders revealed by proton magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Brain Chemistry; Case-Control Studies; Choline; Environmental Exposure; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Manganese; Middle Aged; Neurologic Examination; Protons; Spectrum Analysis; Statistics as Topic; Surveys and Questionnaires; Welding | 2009 |
Daily pattern of pituitary glutamine, glutamate, and aspartate content disrupted by cadmium exposure.
Topics: Animals; Aspartic Acid; Cadmium Chloride; Cadmium Poisoning; Chronobiology Disorders; Circadian Rhythm; Dose-Response Relationship, Drug; Endocrine Disruptors; Glutamic Acid; Glutamine; Male; Organ Specificity; Pituitary Gland; Pituitary Gland, Anterior; Pituitary Gland, Posterior; Rats; Rats, Sprague-Dawley; Xenobiotics | 2010 |
ER export of KAT1 is correlated to the number of acidic residues within a triacidic motif.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acids, Acidic; Arabidopsis; Arabidopsis Proteins; Aspartic Acid; Cell Line; Cell Membrane; Conserved Sequence; COP-Coated Vesicles; Endoplasmic Reticulum; Glutamic Acid; Humans; Membrane Potentials; Membrane Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Protein Binding; Protein Transport; Saccharomyces cerevisiae Proteins; Transfection | 2009 |
Structure-function analysis of the highly conserved charged residues of the membrane protein FT1, the main folic acid transporter of the protozoan parasite Leishmania.
Topics: Amino Acid Sequence; Animals; Anion Transport Proteins; Aspartic Acid; Conserved Sequence; Folic Acid; Glutamic Acid; Leishmania; Membrane Transport Proteins; Molecular Sequence Data; Protein Transport; Protozoan Proteins | 2010 |
Neuronal glutamate transporters regulate synaptic transmission in single synapses on CA1 hippocampal neurons.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; CA1 Region, Hippocampal; Central Nervous System Agents; Cesium; Evoked Potentials; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Models, Neurological; Neurons; Patch-Clamp Techniques; Potassium; Presynaptic Terminals; Rats; Rats, Wistar; Synapses; Synaptic Transmission | 2010 |
Acid residues in the transmembrane helices of the Na+-pumping NADH:quinone oxidoreductase from Vibrio cholerae involved in sodium translocation.
Topics: Aspartic Acid; Bacterial Proteins; Binding Sites; Biological Transport, Active; Glutamic Acid; Hydrogen-Ion Concentration; Membrane Proteins; Mutagenesis, Site-Directed; Quinone Reductases; Sodium; Vibrio cholerae | 2009 |
How can an inert gas counterbalance a NMDA-induced glutamate release?
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Asparagine; Aspartic Acid; Catheters, Indwelling; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Glutamine; Homovanillic Acid; Inert Gas Narcosis; Male; Microdialysis; N-Methylaspartate; Nitrogen; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Statistics, Nonparametric | 2009 |
CE-LIF chiral separation of aspartic acid and glutamic acid enantiomers using human serum albumin and sodium cholate as dual selectors.
Topics: Aspartic Acid; Electrophoresis, Capillary; Fluorescence; Glutamic Acid; Humans; Lasers; Serum Albumin; Sodium Cholate; Stereoisomerism | 2009 |
Simultaneous determination of glutamate and aspartate in rat periaqueductal gray matter microdialysates by capillary electrophoresis with laser-induced fluorescence.
Topics: Animals; Aspartic Acid; Drug Stability; Electrophoresis, Capillary; Fluoresceins; Fluorescence; Glutamic Acid; Least-Squares Analysis; Microdialysis; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Succinimides | 2009 |
Oral supplementation with L-aspartate and L-glutamate inhibits atherogenesis and fatty liver disease in cholesterol-fed rabbit.
Topics: Administration, Oral; Animals; Aspartic Acid; Atherosclerosis; Cholesterol; Cholesterol, Dietary; Fatty Liver; Glutamic Acid; Liver Function Tests; Male; Rabbits; Triglycerides | 2010 |
In vivo glutamate decline associated with kainic acid-induced status epilepticus.
Topics: Analysis of Variance; Animals; Aspartic Acid; Disease Progression; Glutamic Acid; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; Kainic Acid; Lactic Acid; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurons; Organ Size; Rats; Rats, Wistar; Seizures; Status Epilepticus; Time Factors | 2009 |
Properties of a LacY efflux mutant.
Topics: Amino Acid Substitution; Aspartic Acid; Biological Transport, Active; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Hydrogen; Lactose; Membrane Transport Proteins; Mutagenesis, Site-Directed; Protein Binding; Protein Transport | 2009 |
Both B1R and B2R act as intermediate signaling molecules in high glucose-induced stimulation of glutamate uptake in ARPE cells.
Topics: Arachidonic Acid; Aspartic Acid; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagonists; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Epithelial Cells; Excitatory Amino Acid Transporter 4; Gene Expression; Glucose; Glutamic Acid; Humans; Kallikreins; Kininogens; Lysine Carboxypeptidase; NF-kappa B; Phosphorylation; Protein Transport; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Retinal Pigment Epithelium; RNA, Small Interfering; Signal Transduction; Tetrahydroisoquinolines | 2009 |
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport.
Topics: Animals; Animals, Newborn; Aspartic Acid; Biophysics; Disease Models, Animal; Electric Stimulation; Ephrin-A3; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Postsynaptic Potentials; Glial Fibrillary Acidic Protein; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroglia; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Pentylenetetrazole; Receptor, EphA4; Seizures; Signal Transduction; Synapses; Up-Regulation | 2009 |
Striatal metabolic alterations in non-psychotic adolescent offspring at risk for schizophrenia: a (1)H spectroscopy study.
Topics: Adolescent; Aspartic Acid; Chi-Square Distribution; Child; Cohort Studies; Corpus Striatum; Creatine; Energy Metabolism; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Protons; Psychiatric Status Rating Scales; Schizophrenia; Sex Factors; Siblings; Young Adult | 2009 |
Cadmium chloride exposure modifies amino acid daily pattern in the mediobasal hypothalamus in adult male rat.
Topics: Amino Acids; Animals; Aspartic Acid; Cadmium Chloride; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Hypothalamus; Male; Rats; Rats, Sprague-Dawley; Taurine | 2010 |
Neurometabolic changes in the acute phase after sports concussions correlate with symptom severity.
Topics: Acute Disease; Adult; Aspartic Acid; Athletic Injuries; Brain; Brain Concussion; Cognition Disorders; Down-Regulation; Energy Metabolism; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memory Disorders; Motor Cortex; Neuropsychological Tests; Predictive Value of Tests; Self-Assessment; Severity of Illness Index; Young Adult | 2010 |
Time-resolved functional 1H MR spectroscopic detection of glutamate concentration changes in the brain during acute heat pain stimulation.
Topics: Acute Disease; Adult; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Glutamic Acid; Hot Temperature; Humans; Magnetic Resonance Spectroscopy; Male; Pain; Periodicity; Physical Stimulation; Protons; Time Factors | 2010 |
Analysis of nitric oxide metabolism as a placental or maternal factor underlying the etiology of pre-eclampsia.
Topics: Adult; Aspartic Acid; Case-Control Studies; Cyclic GMP; Female; Gestational Age; Glutamic Acid; Humans; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Placenta; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2009 |
Quantitative multivoxel proton spectroscopy of the brain in developmental delay.
Topics: Aspartic Acid; Brain; Case-Control Studies; Child; Child, Preschool; Choline; Creatine; Developmental Disabilities; Female; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Protons; Statistics, Nonparametric | 2009 |
Inhibition of presynaptic release-facilitatory kainate autoreceptors by extracellular cyclic GMP.
Topics: Animals; Aspartic Acid; Autoreceptors; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Extracellular Space; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Synaptosomes | 2010 |
Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy.
Topics: Adult; Aged; Aging; Aspartic Acid; Brain; Brain Chemistry; Female; Glucose Tolerance Test; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mitochondria | 2010 |
In vitro neurotoxic properties and excitatory aminoacids concentration in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. Relationship with the degree of certainty of disease diagnoses.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Cerebrospinal Fluid; Female; Glutamic Acid; Humans; Male; Mice; Middle Aged; Neurons; Time Factors | 2010 |
Vibrational spectroscopy and DFT calculations of the di-amino acid peptide L-aspartyl-L-glutamic acid in the zwitterionic state.
Topics: Amides; Amino Acids; Aspartic Acid; Chemistry, Physical; Glutamic Acid; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Peptides; Solvents; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Vibration | 2009 |
BMI and neuronal integrity in healthy, cognitively normal elderly: a proton magnetic resonance spectroscopy study.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Body Mass Index; Choline; Cognition; Creatine; Female; Frontal Lobe; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Overweight; Reference Values | 2010 |
Identification of a flavin mononucleotide module residue critical for activity of inducible nitrite oxide synthase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid; Cell Line; Dimerization; Enzyme Activation; Flavin Mononucleotide; Glutamic Acid; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Conformation; Protein Structure, Tertiary | 2009 |
Effect of propofol on the levels of neurotransmitters in normal human brain: a magnetic resonance spectroscopy study.
Topics: Acetylcholine; Adult; Anesthetics, Intravenous; Aspartic Acid; Brain; Brain Chemistry; Choline; Consciousness; Creatine; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Neural Inhibition; Neurotransmitter Agents; Propofol; Young Adult | 2009 |
Impact of 4-methylbenzylidene-camphor (4-MBC) during embryonic and fetal development in the neuroendocrine regulation of testicular axis in prepubertal and peripubertal male rats.
Topics: Analysis of Variance; Animals; Aspartic Acid; Camphor; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Follicle Stimulating Hormone; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Hypothalamus; Luteinizing Hormone; Male; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Prolactin; Rats; Rats, Wistar; Sunscreening Agents; Testis | 2009 |
Lower glutamate levels in rostral anterior cingulate of chronic cocaine users - A (1)H-MRS study using TE-averaged PRESS at 3 T with an optimized quantification strategy.
Topics: Adult; Analysis of Variance; Aspartic Acid; Case-Control Studies; Cocaine-Related Disorders; Creatine; Female; Glutamic Acid; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Protons; Spectrum Analysis; Statistics as Topic; Time Factors; Young Adult | 2009 |
Glutamate uptake shapes low-[Mg2+] induced epileptiform activity in juvenile rat hippocampal slices.
Topics: Aging; Animals; Aspartic Acid; CA3 Region, Hippocampal; Dicarboxylic Acids; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Epilepsy; Glutamic Acid; Hippocampus; Kainic Acid; Magnesium; Magnesium Deficiency; Male; Neurons; Neurotransmitter Transport Proteins; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Pyrrolidines; Rats; Rats, Wistar; Synaptic Transmission | 2010 |
1H-MRS at 4 tesla in minimally treated early schizophrenia.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Female; Frontal Lobe; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Nerve Fibers, Myelinated; Protons; Schizophrenia; Thalamus; Time Factors | 2010 |
Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population.
Topics: Adult; Aspartic Acid; Carotid Artery Diseases; Female; Gene Frequency; Genotype; Glutamic Acid; Humans; Male; Middle Aged; Nitric Oxide Synthase Type III; Polymorphism, Genetic; Serbia | 2009 |
Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Biomarkers; Brain; Creatine; Disease Models, Animal; Glutamic Acid; Glutamine; In Vitro Techniques; Inositol; Linear Models; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Protons; Spectrum Analysis; Superoxide Dismutase | 2009 |
Suppressive effects of intrathecal granulocyte colony-stimulating factor on excessive release of excitatory amino acids in the spinal cerebrospinal fluid of rats with cord ischemia: role of glutamate transporters.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Dyskinesias; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Excitatory Amino Acids; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Granulocyte Colony-Stimulating Factor; Injections, Spinal; Male; Nerve Fibers, Unmyelinated; Neuroprotective Agents; Random Allocation; Rats; Rats, Wistar; Spinal Cord; Spinal Cord Ischemia | 2010 |
Region- and pattern-specific effects of glutamate uptake blockers on epileptiform activity in rat brain slices.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Aspartic Acid; Electrophysiology; Entorhinal Cortex; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neurons; Neurotransmitter Uptake Inhibitors; Rats; Rats, Wistar; Synaptic Transmission | 2010 |
Aspartate and glutamate prevents isoproterenol-induced cardiac toxicity by alleviating oxidative stress in rats.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Aspartic Acid; Cardiotonic Agents; Disease Models, Animal; Glutamic Acid; Isoproterenol; Lipid Peroxidation; Male; Mitochondria, Heart; Myocardial Infarction; Myocardium; Oxidative Stress; Rats; Rats, Wistar | 2011 |
Cholesterol depletion attenuates tonic release but increases the ambient level of glutamate in rat brain synaptosomes.
Topics: Animals; Aspartic Acid; beta-Cyclodextrins; Brain; Brain Chemistry; Brain Diseases, Metabolic; Carbon Radioisotopes; Cholesterol; Down-Regulation; Extracellular Fluid; Glutamic Acid; Male; Neurodegenerative Diseases; Neurotoxins; Presynaptic Terminals; Rats; Rats, Wistar; Synaptic Transmission; Synaptosomes; Vesicular Glutamate Transport Proteins | 2010 |
A cryptic role of a glycolytic-gluconeogenic enzyme (aldolase) in amino acid transporter turnover in Aspergillus nidulans.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acids; Aspartic Acid; Aspergillus nidulans; Carbon; DNA, Fungal; Fructose-Bisphosphate Aldolase; Fungal Proteins; Gene Expression Regulation, Fungal; Genetic Complementation Test; Genome, Fungal; Gluconeogenesis; Glutamic Acid; Glycolysis; Molecular Sequence Data; Mutation; Nitrogen; Proline; Sequence Alignment; Sequence Homology, Amino Acid | 2010 |
Inhibitory effects of (2S, 3S)-3-[3-[4-(trifluoromethyl)benzoylamino]benzyloxy]aspartate (TFB-TBOA) on the astrocytic sodium responses to glutamate.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Central Nervous System Agents; Cerebral Cortex; D-Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Intracellular Space; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sodium | 2010 |
Interactions at the 2 and 5 positions of 5-phosphoribosyl pyrophosphate are essential in Salmonella typhimurium quinolinate phosphoribosyltransferase.
Topics: Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Catalytic Domain; Enzyme Stability; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Protein Binding; Salmonella typhimurium; Substrate Specificity | 2010 |
A novel method of production and biophysical characterization of the catalytic domain of yeast oligosaccharyl transferase.
Topics: Amino Acid Substitution; Aspartic Acid; Catalytic Domain; Escherichia coli; Glutamic Acid; Hexosyltransferases; Magnetic Resonance Spectroscopy; Membrane Proteins; Micelles; Mutagenesis, Site-Directed; Protein Subunits; Recombinant Proteins; Saccharomyces cerevisiae Proteins; Sodium Dodecyl Sulfate; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2010 |
Ciliary neurotrophic factor protects striatal neurons against excitotoxicity by enhancing glial glutamate uptake.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Ciliary Neurotrophic Factor; Corpus Striatum; Evoked Potentials; Glutamic Acid; In Vitro Techniques; Neurons; Quinolinic Acid; Rats | 2010 |
Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signaling.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Benzoxazoles; Calcium; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Transporter 1; Female; Gene Expression Regulation; Glutamic Acid; Humans; Injections, Spinal; Neurons; Phosphatidylinositol 3-Kinases; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinolinium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X7; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Spinal Cord Injuries; Transfection | 2010 |
Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuregulin-1; Phencyclidine; Phenotype; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Sex Factors; Social Behavior | 2010 |
Endothelial nitric oxide synthase Glu298Asp gene polymorphism in a multi-ethnical population with heart failure and controls.
Topics: Alleles; Aspartic Acid; Brazil; Case-Control Studies; Ethnicity; Female; Genotype; Glutamic Acid; Heart Failure; Humans; Male; Middle Aged; Nitric Oxide Synthase Type III; Polymorphism, Genetic | 2010 |
X-ray absorption studies of Zn(2+)-binding sites in Escherichia coli transhydrogenase and its betaH91K mutant.
Topics: Amino Acid Substitution; Aspartic Acid; Binding Sites; Cysteine; Escherichia coli Proteins; Glutamic Acid; Histidine; Models, Molecular; Mutation; NADP Transhydrogenases; Protein Binding; Protein Structure, Tertiary; Spectrometry, X-Ray Emission; Zinc | 2010 |
The Glu298ASP polymorphism of the endothelial nitric oxide synthase gene is associated with premature ST elevation myocardial infarction in Mexican population.
Topics: Adult; Alleles; Amino Acid Substitution; Aspartic Acid; Case-Control Studies; Electrocardiography; Electrophoresis, Agar Gel; Female; Genotype; Glutamic Acid; Humans; Male; Mexico; Middle Aged; Myocardial Infarction; Nitric Oxide Synthase Type III; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Risk Factors | 2010 |
Pyruvate carboxylase plays a crucial role in carbon metabolism of extra- and intracellularly replicating Listeria monocytogenes.
Topics: Animals; Aspartic Acid; Bacterial Proteins; Carbon; Carbon Isotopes; Cell Line; Culture Media; Epithelial Cells; Female; Gene Deletion; Glucose; Glutamic Acid; Humans; Listeria monocytogenes; Macrophages; Mice; Mice, Inbred C57BL; Mutagenesis, Insertional; Oxaloacetic Acid; Pyruvate Carboxylase; Pyruvic Acid; Sepsis; Virulence | 2010 |
Interaction between the natural lipopeptide [Glu1, Asp5)] surfactin-C15 and hemoglobin in aqueous solution.
Topics: Aspartic Acid; Glutamic Acid; Hemoglobins; Lipopeptides; Solutions | 2010 |
Comparison of dissolution and surface reactions between calcite and aragonite in L-glutamic and L-aspartic acid solutions.
Topics: Acetic Acid; Aspartic Acid; Calcium; Calcium Carbonate; Glutamic Acid; Kinetics; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Solubility; Solutions; Spectroscopy, Fourier Transform Infrared; Surface Properties; Time Factors; X-Ray Diffraction | 2010 |
A pressurized nitrogen counterbalance to cortical glutamatergic pathway stimulation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Asparagine; Aspartic Acid; Baclofen; Corpus Striatum; Dopamine; Glutamic Acid; Glutamine; Homovanillic Acid; Hyperbaric Oxygenation; Inert Gas Narcosis; Male; Nitrogen; Pressure; Rats; Rats, Sprague-Dawley | 2010 |
Evidence for Avt6 as a vacuolar exporter of acidic amino acids in Saccharomyces cerevisiae cells.
Topics: Amino Acid Transport Systems; Amino Acids, Acidic; Aspartic Acid; Biological Transport; Culture Media; Gene Expression Regulation, Fungal; Glutamic Acid; Green Fluorescent Proteins; Intracellular Membranes; Nitrogen; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Vacuoles | 2009 |
The DC gate in Channelrhodopsin-2: crucial hydrogen bonding interaction between C128 and D156.
Topics: Algal Proteins; Amino Acid Substitution; Aspartic Acid; Chlamydomonas reinhardtii; Cystine; Glutamic Acid; Hydrogen Bonding; Ion Channels; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared | 2010 |
[Study on the mechanism of electroacupuncture of different acupoint groups in the treatment of cerebrocardiac syndrome in rats].
Topics: Acupuncture Points; Animals; Aspartic Acid; Brain; Brain Diseases; Disease Models, Animal; Electroacupuncture; Female; Glutamic Acid; Heart Diseases; Humans; Male; Random Allocation; Rats; Rats, Wistar | 2009 |
Metabolic changes in a pyruvate kinase gene deletion mutant of Corynebacterium glutamicum ATCC 13032.
Topics: Aspartic Acid; Biotin; Corynebacterium glutamicum; Glucose; Glutamic Acid; Metabolic Networks and Pathways; Oxaloacetic Acid; Phosphoenolpyruvate Carboxykinase (ATP); Phosphoenolpyruvate Carboxylase; Pyruvate Kinase; Sequence Deletion | 2010 |
Metabolite concentrations in supraventricular white matter from teenage to early old age: A short echo time 1H magnetic resonance spectroscopy (MRS) study.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Aspartic Acid; Biomarkers; Brain; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Lipid Metabolism; Magnetic Resonance Spectroscopy; Male; Middle Aged; Myelin Sheath; Reference Values; Young Adult | 2010 |
Age estimation by racemization method in teeth: application of aspartic acid, glutamate, and alanine.
Topics: Adolescent; Adult; Age Determination by Teeth; Aged; Aged, 80 and over; Alanine; Aspartic Acid; Bicuspid; Biomarkers; Dentin; Flame Ionization; Forensic Dentistry; Glutamic Acid; Humans; Linear Models; Middle Aged; Young Adult | 2010 |
Neurochemical alterations in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder.
Topics: Adult; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Borderline Personality Disorder; Brain Chemistry; Case-Control Studies; Cerebellum; Choline; Creatine; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy | 2010 |
Riluzole normalizes early-life stress-induced visceral hypersensitivity in rats: role of spinal glutamate reuptake mechanisms.
Topics: Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Glutamic Acid; Irritable Bowel Syndrome; Male; Maternal Deprivation; Motor Activity; Rats; Rats, Sprague-Dawley; Riluzole; Spinal Cord; Stress, Psychological | 2010 |
Chemical fragments that hydrogen bond to Asp, Glu, Arg, and His side chains in protein binding sites.
Topics: Arginine; Aspartic Acid; Binding Sites; Databases, Factual; Glutamic Acid; Histidine; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Structure | 2010 |
Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes.
Topics: Aspartic Acid; Binding Sites; Calcium; Crystallography, X-Ray; Glutamic Acid; Humans; Intrinsic Factor; Ligands; Models, Molecular; Protein Binding; Protein Structure, Tertiary; Receptors, Cell Surface; Static Electricity; Vitamin B 12 | 2010 |
The relationship of glutamic and aspartic acids to the production of nausea and vomiting in man.
Topics: Acids; Amino Acids; Aspartic Acid; Glutamates; Glutamic Acid; Humans; Male; Nausea; Vomiting | 1947 |
A new adsorption apparatus and the separation of aspartic and glutamic acid.
Topics: Adsorption; Aspartic Acid; Glutamates; Glutamic Acid | 1947 |
Determination of aspartic-glutamic transaminase in tissue homogenates.
Topics: Aspartate Aminotransferases; Aspartic Acid; Glutamic Acid; Humans; Transaminases | 1946 |
Studies on glutamic-aspartic acid transaminase.
Topics: Amino Acids; Aspartate Aminotransferases; Aspartic Acid; Glutamic Acid; Transaminases | 1947 |
A self-referencing glutamate biosensor for measuring real time neuronal glutamate flux.
Topics: Animals; Aspartic Acid; Biological Transport, Active; Biosensing Techniques; Brain Chemistry; Cells, Cultured; Electric Stimulation; Electrophysiology; Glutamic Acid; Mice; Neurochemistry; Neurons; Oxidoreductases; Reaction Time; Synaptic Transmission; Time Factors | 2010 |
Conformational consequences of ionization of Lys, Asp, and Glu buried at position 66 in staphylococcal nuclease.
Topics: Aspartic Acid; Circular Dichroism; Crystallography, X-Ray; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Lysine; Micrococcal Nuclease; Models, Molecular; Protein Conformation; Thermodynamics | 2010 |
Coupled amino acid deamidase-transport systems essential for Helicobacter pylori colonization.
Topics: Amino Acid Transport Systems, Acidic; Amino Acids; Ammonia; Animals; Asparaginase; Aspartic Acid; Bacterial Proteins; Colony Count, Microbial; Dicarboxylic Acid Transporters; gamma-Glutamyltransferase; Glutamic Acid; Helicobacter pylori; Humans; Hydrogen-Ion Concentration; Mice; Models, Biological; Stomach; Virulence; Virulence Factors | 2010 |
The unique kinetic behavior of the very large NAD-dependent glutamate dehydrogenase from Janthinobacterium lividum.
Topics: Aspartic Acid; Catalysis; Chromobacterium; Glutamate Dehydrogenase; Glutamic Acid; Ketoglutaric Acids; Kinetics; NAD; Oxalobacteraceae | 2010 |
The role of glutamic or aspartic acid in position four of the epitope binding motif and thyrotropin receptor-extracellular domain epitope selection in Graves' disease.
Topics: Amino Acid Substitution; Animals; Antigen Presentation; Aspartic Acid; Epitopes; Extracellular Space; Glutamic Acid; Graves Disease; HLA Antigens; HLA-DR Antigens; HLA-DR3 Antigen; HLA-DR7 Antigen; Humans; Immunization; Lymphocytes; Mice; Receptors, Thyrotropin | 2010 |
Brain glutamatergic characteristics of pediatric offspring of parents with bipolar disorder.
Topics: Adolescent; Analysis of Variance; Aspartic Acid; Bipolar Disorder; Brain Mapping; Child; Child of Impaired Parents; Cohort Studies; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Pediatrics; Protons; Psychiatric Status Rating Scales | 2010 |
Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Blood Glucose; Brain; Diabetes Mellitus, Type 2; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycogen; Male; Obesity; Rats; Rats, Sprague-Dawley; Rats, Zucker | 2010 |
Hypertrophic cardiomyopathy-linked mutation D145E drastically alters calcium binding by the C-domain of cardiac troponin C.
Topics: Amino Acid Substitution; Aspartic Acid; Calcium; Calcium Signaling; Cardiomyopathy, Hypertrophic; Glutamic Acid; Humans; Magnesium; Muscle Contraction; Mutation; Protein Binding; Protein Structure, Tertiary; Troponin C | 2010 |
The impact of blood pressure on hippocampal glutamate and mnestic function.
Topics: Adult; Aspartic Acid; Blood Pressure; Cognition; Cognition Disorders; Female; Germany; Glutamic Acid; Gyrus Cinguli; Hippocampus; Humans; Hypertension; Linear Models; Magnetic Resonance Spectroscopy; Male; Memory; Middle Aged; Neuropsychological Tests; Young Adult | 2011 |
The position of an arginine residue influences substrate affinity and K+ coupling in the human glutamate transporter, EAAT1.
Topics: Animals; Archaeal Proteins; Arginine; Aspartic Acid; Binding Sites; Biological Transport, Active; Cations, Monovalent; Excitatory Amino Acid Transporter 1; Female; Glutamic Acid; Humans; Mutagenesis, Site-Directed; Oocytes; Potassium; Protein Binding; Pyrococcus horikoshii; Xenopus laevis | 2010 |
Co-administration of ultra-low dose naloxone attenuates morphine tolerance in rats via attenuation of NMDA receptor neurotransmission and suppression of neuroinflammation in the spinal cords.
Topics: Amino Acid Transport System X-AG; Analgesics; Animals; Aspartic Acid; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Gene Expression Regulation; Glutamic Acid; Injections, Spinal; Male; Morphine; Naloxone; Neuroglia; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 2010 |
Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum.
Topics: Action Potentials; Animals; Animals, Newborn; Aspartic Acid; Cerebellum; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 4; GABA Antagonists; Glutamic Acid; Green Fluorescent Proteins; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Fibers; Nerve Tissue Proteins; Purkinje Cells; Pyridazines; Vesicular Glutamate Transport Protein 2; Zinc | 2010 |
Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation.
Topics: Animals; Aspartic Acid; CHO Cells; Cricetinae; Cricetulus; Dimerization; ErbB Receptors; Glutamic Acid; Mice; Mutation; Protein Conformation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Signal Transduction; Structure-Activity Relationship | 2010 |
The contribution of interchain salt bridges to triple-helical stability in collagen.
Topics: Aspartic Acid; Collagen; Glutamic Acid; Lysine; Molecular Dynamics Simulation; Peptides; Protein Conformation; Protein Stability; Protein Structure, Secondary; Thermodynamics; Time Factors | 2010 |
A conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4).
Topics: Anions; Aspartic Acid; Biophysics; Cell Membrane; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Transporter 4; Glutamic Acid; Humans; Kinetics; Neurotransmitter Agents; Patch-Clamp Techniques; Permeability; Protein Isoforms; Protein Structure, Tertiary | 2010 |
Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex.
Topics: Amygdala; Animals; Aspartic Acid; Creatine; Energy Metabolism; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stress Disorders, Post-Traumatic; Stress, Psychological; Synaptic Transmission | 2010 |
Bidirectional neuron-glia interactions triggered by deficiency of glutamate uptake at spinal sensory synapses.
Topics: Amino Acids; Animals; Aspartic Acid; Biophysics; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Male; Neural Pathways; Neuroglia; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Spinal Cord; Synapses | 2010 |
The fate of synaptic input to NG2 glial cells: neurons specifically downregulate transmitter release onto differentiating oligodendroglial cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; Animals; Animals, Newborn; Antigens; Aspartic Acid; Bicuculline; Cell Differentiation; Down-Regulation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Agents; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Mice; Mice, Transgenic; Myelin Proteolipid Protein; Neurons; Neurotransmitter Agents; Nipecotic Acids; Oligodendroglia; Patch-Clamp Techniques; Proteoglycans; Stem Cells; Synapses | 2010 |
Site-directed mutagenesis of rice serine racemase: evidence that Glu219 and Asp225 mediate the effects of Mg2+ on the activity.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Binding Sites; Biocatalysis; Glutamic Acid; Kinetics; Magnesium; Molecular Sequence Data; Mutagenesis, Site-Directed; Oryza; Racemases and Epimerases; Spectrometry, Fluorescence | 2010 |
Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats.
Topics: Aging; Animals; Aspartic Acid; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Synapses; Synaptic Transmission; Tissue Distribution | 2010 |
Cadmium effects on 24h changes in glutamate, aspartate, glutamine, GABA and taurine content of rat striatum.
Topics: Amino Acids; Animals; Aspartic Acid; Cadmium; Circadian Rhythm; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Male; Neostriatum; Rats; Rats, Sprague-Dawley; Taurine; Time Factors | 2010 |
Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate.
Topics: Adult; Aspartic Acid; Brain; Cholic Acid; Cross-Sectional Studies; Diffusion Tensor Imaging; Female; Fibromyalgia; Glutamic Acid; Glutamine; Hippocampus; Humans; Inositol; Male; Middle Aged; Motor Cortex; Nuclear Magnetic Resonance, Biomolecular; Pain; Protons; Somatosensory Cortex | 2010 |
Thalamic neurochemical abnormalities in individuals with prodromal symptoms of schizophrenia - relationship to auditory event-related potentials.
Topics: Acoustic Stimulation; Adult; Aspartic Acid; Electroencephalography; Evoked Potentials, Auditory; Female; Frontal Lobe; Glutamic Acid; Glutamine; Humans; Linear Models; Magnetic Resonance Spectroscopy; Male; Neurochemistry; Protons; Radionuclide Imaging; Schizophrenia; Thalamus; Young Adult | 2010 |
Pre-synaptic nicotinic receptors evoke endogenous glutamate and aspartate release from hippocampal synaptosomes by way of distinct coupling mechanisms.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Aspartic Acid; Calcium; Chromatography, High Pressure Liquid; Glutamic Acid; Hippocampus; Male; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission; Synaptosomes | 2010 |
Effect of acute psychological stress on prefrontal GABA concentration determined by proton magnetic resonance spectroscopy.
Topics: Acute Disease; Adult; Animals; Anxiety; Anxiety Disorders; Aspartic Acid; Choline; Diagnostic and Statistical Manual of Mental Disorders; Down-Regulation; Electroshock; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Psychiatric Status Rating Scales; Stress, Psychological; Synaptic Transmission | 2010 |
Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dialysis; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Male; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus; Survival Analysis; Thioctic Acid | 2011 |
Symptomatic and neuroprotective effects following activation of nigral group III metabotropic glutamate receptors in rodent models of Parkinson's disease.
Topics: Aminobutyrates; Animals; Aspartic Acid; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Immunohistochemistry; Male; Microdialysis; Motor Activity; Neuroprotective Agents; Parkinson Disease; Phosphoserine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Substantia Nigra | 2010 |
The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cell Line; Exenatide; Glucagon-Like Peptide-1 Receptor; Glutamic Acid; Humans; Hydrogen Bonding; Hypoglycemic Agents; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Peptides; Protein Conformation; Protein Structure, Tertiary; Radioligand Assay; Rats; Receptors, Glucagon; Recombinant Proteins; Serine; Structure-Activity Relationship; Transfection; Venoms | 2010 |
Alterations of glutamate release in the spinal cord of mice with experimental autoimmune encephalomyelitis.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Glutamic Acid; Glycoproteins; In Vitro Techniques; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Neuroglia; Neurons; Peptide Fragments; Potassium Chloride; Spinal Cord; Subcellular Fractions; Tritium | 2010 |
Non-invasive evaluation of the GABAergic/glutamatergic system in autistic patients observed by MEGA-editing proton MR spectroscopy using a clinical 3 tesla instrument.
Topics: Analysis of Variance; Aspartic Acid; Autistic Disorder; Child; Child, Preschool; Corpus Striatum; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy | 2011 |
Metabolic flux determination in perfused livers by mass balance analysis: effect of fasting.
Topics: Animals; Aspartic Acid; Fasting; Fatty Acids; Gluconeogenesis; Glucose; Glutamic Acid; Glycogen; In Vitro Techniques; Liver; Pentose Phosphate Pathway; Perfusion; Rats; Up-Regulation | 2010 |
Inhibition of Streptococcus mutans adherence and biofilm formation using analogues of the SspB peptide.
Topics: Adhesins, Bacterial; Amino Acid Sequence; Aspartic Acid; Bacterial Adhesion; Binding, Competitive; Biofilms; Biosensing Techniques; Dental Pellicle; Glutamic Acid; Humans; Lysine; Peptides; Protein Binding; Protein Structure, Secondary; Salivary Proteins and Peptides; Streptococcus gordonii; Streptococcus mutans | 2010 |
Interindividual, repositioning, and time-of-day effects on single voxel proton MR spectroscopy of the anterior cingulate cortex.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Imaging, Three-Dimensional; Inositol; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Protons; Reproducibility of Results; Time Factors | 2010 |
Pre-synaptic BK channels selectively control glutamate versus GABA release from cortical and hippocampal nerve terminals.
Topics: Animals; Animals, Newborn; Area Under Curve; Aspartic Acid; Calcium; Cells, Cultured; Cerebral Cortex; Cricetinae; Cricetulus; Dopamine; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Hippocampus; Male; Mice; Mice, Knockout; Microscopy, Confocal; Norepinephrine; Peptides; Potassium Channels, Calcium-Activated; Presynaptic Terminals; Rats; Rats, Wistar; Synaptophysin; Synaptosomes; Transfection; Tritium; Vesicular Glutamate Transport Protein 1 | 2010 |
Multi-voxel magnetic resonance spectroscopy at 3 T in patients with idiopathic generalised epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Basal Ganglia; Brain; Cerebral Cortex; Choline; Creatine; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Hippocampus; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Thalamus; Young Adult | 2010 |
(1)H MR spectroscopy in Friedreich's ataxia and ataxia with oculomotor apraxia type 2.
Topics: Adult; Aspartic Acid; Brain Mapping; Creatine; Female; Friedreich Ataxia; Gait Ataxia; Glutamic Acid; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Ocular Motility Disorders; Protons; Spectrum Analysis; Statistics as Topic; Young Adult | 2010 |
Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation.
Topics: Alanine; Animals; Aspartic Acid; Astrocytes; Brain Chemistry; Cells, Cultured; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Immunohistochemistry; Lactic Acid; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron; Neurons; Nitrogen; Pyruvic Acid | 2011 |
Amino acid uptake profiling of wild type and recombinant Streptomyces lividans TK24 batch fermentations.
Topics: Amino Acids; Animals; Aspartic Acid; Biomass; Biotechnology; Fermentation; Glutamic Acid; Metabolome; Mice; Protein Biosynthesis; Species Specificity; Streptomyces lividans; Tumor Necrosis Factor-alpha | 2011 |
Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis.
Topics: Adult; Aspartic Acid; Brain; Computer Simulation; Female; Follow-Up Studies; Gene Frequency; Genetic Variation; Genome-Wide Association Study; Genotype; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Models, Genetic; Multiple Sclerosis; Oxidoreductases Acting on Sulfur Group Donors; Polymorphism, Single Nucleotide; Statistics as Topic; Sulfatases | 2010 |
A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Calcium; Chloride Channels; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Ion Channel Gating; Kidney; Kinetics; Membrane Potentials; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Patch-Clamp Techniques; Protein Subunits; Structure-Activity Relationship; Xenopus | 2010 |
[Effect of Chaihu Shugan Tang on excitability in different brain regions of pentylenetetrazole-kindled chronic epileptic rats].
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Aspartic Acid; Brain; Chronic Disease; Deoxyglucose; Disease Models, Animal; Drugs, Chinese Herbal; Epilepsy; Glutamic Acid; Hippocampus; Humans; Kindling, Neurologic; Male; Pentylenetetrazole; Random Allocation; Rats; Valproic Acid | 2010 |
TNF-α potentiates glutamate-induced spinal cord motoneuron death via NF-κB.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Death; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Inflammation; Motor Neurons; NF-kappa B; Organ Culture Techniques; Oxidative Stress; Rats; Signal Transduction; Spinal Cord; Tumor Necrosis Factor-alpha | 2011 |
Neuroprotective effect of CPDT on THA-induced cortical motor neuron death in an organotypic culture model.
Topics: Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Bacterial Toxins; Cell Death; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Heme Oxygenase-1; Motor Cortex; Motor Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Organ Culture Techniques; Rats | 2010 |
A conserved glutamate controls the commitment to acyl-adenylate formation in asparagine synthetase.
Topics: Adenosine Monophosphate; Ammonia; Aspartate-Ammonia Ligase; Aspartic Acid; Catalytic Domain; Escherichia coli Proteins; Glutamic Acid; Kinetics; Mutagenesis, Site-Directed | 2010 |
Acquisition of Raman spectra of amino acids using portable instruments: outdoor measurements and comparison.
Topics: Alanine; Amino Acids; Asparagine; Aspartic Acid; beta-Alanine; Glutamic Acid; Glutamine; Glycine; Methionine; Proline; Research Design; Robotics; Serine; Spectrum Analysis, Raman; Transportation; Tryptophan; Tyrosine; Workplace | 2010 |
1H-MR spectroscopic detection of metabolic changes in pain processing brain regions in the presence of non-specific chronic low back pain.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Low Back Pain; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pain Perception; Young Adult | 2011 |
Ventromedial prefrontal spectroscopic abnormalities over the course of depression: a comparison among first episode, remitted recurrent and chronic patients.
Topics: Adult; Age of Onset; Aspartic Acid; Choline; Chronic Disease; Depressive Disorder, Major; Disease Progression; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multivariate Analysis; Prefrontal Cortex | 2011 |
New evidence for the role of calcium in the glycosidase reaction of GH43 arabinanases.
Topics: Amino Acid Substitution; Aspartic Acid; Bacillus subtilis; Calcium; Catalytic Domain; Crystallography, X-Ray; Glutamic Acid; Glycoside Hydrolases; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Substrate Specificity; Temperature | 2010 |
Anterior cingulate and cerebellar GABA and Glu correlations measured by ¹H J-difference spectroscopy.
Topics: Adult; Aspartic Acid; Cerebellum; Creatine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Protons; Statistics as Topic; Tissue Distribution | 2011 |
Quantitative in vivo brain magnetic resonance spectroscopic monitoring of neurological involvement in mucopolysaccharidosis type II (Hunter Syndrome).
Topics: Adolescent; Aspartic Acid; Basal Ganglia; Biomarkers; Brain; Case-Control Studies; Child; Child, Preschool; Choline; Disease Progression; Enzyme Replacement Therapy; Glutamic Acid; Humans; Iduronate Sulfatase; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mucopolysaccharidosis II; Predictive Value of Tests; Treatment Outcome | 2010 |
Insula-specific responses induced by dental pain. A proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Cerebral Cortex; Electrodes; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Models, Anatomic; Neurotransmitter Agents; Pain; Prospective Studies; Protons; Tooth Diseases; Trigeminal Nerve | 2011 |
Effect of aspartate and glutamate on the fate of enhanced biological phosphorus removal process and microbial community structure.
Topics: Aerobiosis; Anaerobiosis; Aspartic Acid; Bacteria; Biodegradation, Environmental; Biomass; Bioreactors; DNA, Ribosomal; Glutamic Acid; Molecular Sequence Data; Oxygen; Phosphorus; Polyhydroxyalkanoates; Polyphosphates; Sewage | 2011 |
Neurometabolite abnormalities in simian immunodeficiency virus-infected macaques with chronic morphine administration.
Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Creatine; Glutamic Acid; Inositol; Macaca; Magnetic Resonance Spectroscopy; Male; Morphine; Morphine Dependence; Narcotics; Simian Acquired Immunodeficiency Syndrome; Viral Load | 2011 |
Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy.
Topics: Adult; Analysis of Variance; Aspartic Acid; Creatine; Depressive Disorder, Major; Electroconvulsive Therapy; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Mental Recall; Middle Aged; Neuropsychological Tests; Phosphocreatine; Prefrontal Cortex; Severity of Illness Index; Treatment Outcome; Verbal Learning | 2011 |
In vitro measurements of extracellular L-glutamate level in region CA3 of mouse hippocampal slices under chemical stimulation.
Topics: Animals; Aspartic Acid; CA3 Region, Hippocampal; Glutamic Acid; Mice; Potassium Chloride; Stimulation, Chemical; Tetraethylammonium | 2010 |
Developmental and metabolic brain alterations in rats exposed to bisphenol A during gestation and lactation.
Topics: Animals; Aspartic Acid; Benzhydryl Compounds; Brain; Endocrine Disruptors; Energy Metabolism; Estrogens, Non-Steroidal; Female; Glutamic Acid; Humans; Lactation; Magnetic Resonance Spectroscopy; Male; Neuroglia; Neurons; Phenols; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2011 |
Substitution of aspartic acid with glutamic acid at position 67 of the BRCA1 RING domain retains ubiquitin ligase activity and zinc(II) binding with a reduced transition temperature.
Topics: Aspartic Acid; BRCA1 Protein; Chromatography, Gel; Circular Dichroism; Female; Glutamic Acid; Humans; Mass Spectrometry; Protein Binding; Structure-Activity Relationship; Ubiquitin-Protein Ligases; X-Ray Absorption Spectroscopy; Zinc | 2011 |
Glutamate as a marker of cognitive function in schizophrenia: a proton spectroscopic imaging study at 4 Tesla.
Topics: Adult; Age Factors; Aspartic Acid; Biomarkers; Brain; Cognition Disorders; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neuropsychological Tests; Protons; Schizophrenia; Schizophrenic Psychology | 2011 |
A functional polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, dysfunction, and ischemia: data from the heart and soul study.
Topics: Aged; Aspartic Acid; Cardiomegaly; Female; Glutamic Acid; Humans; Male; Middle Aged; Monoamine Oxidase; Myocardial Ischemia; Polymorphism, Single Nucleotide; Prospective Studies | 2010 |
Pivotal roles of three conserved carboxyl residues of the NuoC (30k) segment in the structural integrity of proton-translocating NADH-quinone oxidoreductase from Escherichia coli.
Topics: Amino Acid Sequence; Aspartic Acid; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Protein Subunits; Protons; Quinone Reductases; Sequence Alignment | 2010 |
A vesicular transporter that mediates aspartate and glutamate neurotransmission.
Topics: Animals; Aspartic Acid; Biological Transport; Glutamic Acid; Hippocampus; Humans; Mutation; N-Acetylneuraminic Acid; Organic Anion Transporters; Pineal Gland; Sialic Acid Storage Disease; Synaptic Transmission; Synaptic Vesicles | 2010 |
Structural origins of high apparent dielectric constants experienced by ionizable groups in the hydrophobic core of a protein.
Topics: Aspartic Acid; Glutamic Acid; Hydrogen; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Lysine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Micrococcal Nuclease; Models, Molecular; Protein Conformation; Static Electricity; Thermodynamics | 2011 |
Glutamate induces glutathione efflux mediated by glutamate/aspartate transporter in retinal cell cultures.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Dicarboxylic Acids; Glutamic Acid; Glutathione; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Retina | 2011 |
Expression of multiple glutamate transporter splice variants in the rodent testis.
Topics: Alternative Splicing; Amino Acid Sequence; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Base Sequence; Brain; DNA Primers; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Excitatory Amino Acid Transporter 4; Excitatory Amino Acid Transporter 5; Gene Expression; Glutamic Acid; Homeostasis; Immunohistochemistry; Male; Molecular Sequence Data; Rats; Retina; RNA, Messenger; Testis | 2011 |
Location of glutamatergic/aspartatergic neurons projecting to the hypothalamic ventromedial nucleus studied by autoradiography of retrogradely transported [³H]D-aspartate.
Topics: Animals; Aspartic Acid; Autoradiography; Glutamic Acid; Immunohistochemistry; Neural Pathways; Neurons; Rats; Rats, Sprague-Dawley; Ventromedial Hypothalamic Nucleus | 2011 |
Gamma-aminobutyric acid concentrations in benign parotid tumours and unstimulated parotid saliva.
Topics: Adenolymphoma; Adenoma, Pleomorphic; Adolescent; Adult; Aged; Aspartic Acid; Cell Proliferation; Chromatography, Liquid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Middle Aged; Parotid Gland; Parotid Neoplasms; Saliva; Young Adult | 2011 |
Evaluating glutamate and aspartate binding mechanisms to rutile (α-TiO2) via ATR-FTIR spectroscopy and quantum chemical calculations.
Topics: Aspartic Acid; Glutamic Acid; Models, Molecular; Molecular Conformation; Quantum Theory; Spectroscopy, Fourier Transform Infrared; Surface Properties; Titanium; Water | 2011 |
Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Glutamic Acid; Inflammation; Kainic Acid; Male; Nicotinic Acids; Pain; Phosphoserine; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord | 2011 |
Age-dependent remodelling of ionotropic signalling in cortical astroglia.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Cell Communication; Excitatory Amino Acid Antagonists; Glutamic Acid; Mice; Mice, Transgenic; Neocortex; Neurons; Neurotransmitter Agents; Purinergic P2X Receptor Antagonists; Receptors, AMPA; Receptors, Ionotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P2X; Synaptic Potentials; Synaptic Transmission; Tissue Culture Techniques | 2011 |
Prenatal exposure to PCP produces behavioral deficits accompanied by the overexpression of GLAST in the prefrontal cortex of postpubertal mice.
Topics: Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Behavioral Symptoms; Body Weight; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Female; Gene Expression Regulation, Developmental; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Microdialysis; Neurons; Phencyclidine; Potassium; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Recognition, Psychology; Swimming | 2011 |
The Rho kinase inhibitor Fasudil up-regulates astrocytic glutamate transport subsequent to actin remodelling in murine cultured astrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Glutamic Acid; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Prosencephalon; rho-Associated Kinases; Up-Regulation | 2011 |
Riluzole is a potent drug to protect neonatal rat hypoglossal motoneurons in vitro from excitotoxicity due to glutamate uptake block.
Topics: Action Potentials; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Astrocytes; Bicuculline; Biomarkers; Convulsants; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; Hypoglossal Nerve; Motor Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Rats; Riluzole; Strychnine | 2011 |
Memory impairment associated with neurometabolic abnormalities of the hippocampus in patients with non-neuropsychiatric systemic lupus erythematosus.
Topics: Adult; Aspartic Acid; Case-Control Studies; Creatine; Female; Glutamic Acid; Hippocampus; Humans; Lupus Erythematosus, Systemic; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Prospective Studies | 2011 |
Thermal and physicochemical properties and nutritional value of the protein fraction of Mexican chia seed (Salvia hispanica L.).
Topics: Arginine; Aspartic Acid; Calorimetry, Differential Scanning; Chemical Phenomena; Corn Oil; Digestion; Food, Fortified; Gels; Glutamic Acid; Glutens; Mexico; Nutritive Value; Plant Preparations; Plant Proteins; Protein Stability; Salvia; Seeds; Temperature; Water | 2010 |
Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions.
Topics: Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; Immunoprecipitation; Magnesium; Male; N-Methylaspartate; Pipecolic Acids; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tetrahydronaphthalenes; Tritium | 2011 |
Neurochemical alterations in adolescent chronic marijuana smokers: a proton MRS study.
Topics: Adolescent; Aspartic Acid; Brain Chemistry; Female; Glutamic Acid; Gyrus Cinguli; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Marijuana Smoking; Young Adult | 2011 |
[Effect of polydatin on dynamic changes of excitatory amino acids in cerebrospinal fluid of cerebral hemorrhage rats].
Topics: Animals; Aspartic Acid; Cerebral Hemorrhage; Disease Models, Animal; Drugs, Chinese Herbal; Excitatory Amino Acids; Glucosides; Glutamic Acid; Humans; Male; Rats; Rats, Sprague-Dawley; Stilbenes | 2010 |
C- and N-catabolic utilization of tricarboxylic acid cycle-related amino acids by Scheffersomyces stipitis and other yeasts.
Topics: Amino Acids; Aspartic Acid; Biomass; Citric Acid Cycle; DNA, Fungal; Ethanol; Fermentation; Glutamate Dehydrogenase; Glutamic Acid; Industrial Microbiology; Mitosporic Fungi; Mutagenesis, Insertional; Polymerase Chain Reaction; Proline; Transformation, Genetic | 2011 |
A survey of aspartate-phenylalanine and glutamate-phenylalanine interactions in the protein data bank: searching for anion-π pairs.
Topics: Aspartic Acid; Binding Sites; Databases, Protein; Energy Transfer; Glutamic Acid; Hydrogen Bonding; Models, Molecular; Phenylalanine; Protein Binding; Protein Conformation; Protein Stability; Protein Structure, Secondary; Proteins; Thermodynamics | 2011 |
Intramolecular cyclization of N-phenyl N'(2-chloroethyl)ureas leads to active N-phenyl-4,5-dihydrooxazol-2-amines alkylating β-tubulin Glu198 and prohibitin Asp40.
Topics: Alkylating Agents; Amines; Animals; Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Cyclization; Electrophoresis, Gel, Two-Dimensional; Fluorescent Antibody Technique; Glutamic Acid; Melanoma, Experimental; Mice; Prohibitins; Repressor Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tubulin; Urea | 2011 |
Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells.
Topics: Alanine; Animals; Aspartic Acid; Cell Membrane; Cells, Cultured; Dicarboxylic Acids; Epinephrine; gamma-Aminobutyric Acid; Glucagon; Glucagon-Secreting Cells; Glucose; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutamine; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ketoglutaric Acids; Malates; Male; Pyrrolidines; Rats; Rats, Wistar; Transcription, Genetic | 2011 |
Hypertrophic cardiomyopathy-causing Asp175asn and Glu180gly Tpm1 mutations shift tropomyosin strands further towards the open position during the ATPase cycle.
Topics: Actins; Adenosine Triphosphatases; Amino Acid Substitution; Aspartic Acid; Cardiomyopathy, Hypertrophic; Glutamic Acid; Humans; Mutation; Protein Conformation; Tropomyosin | 2011 |
Influence of work shift on glutamic acid and gamma-aminobutyric acid (GABA): evaluation with proton magnetic resonance spectroscopy at 3T.
Topics: Adult; Aspartic Acid; Brain; Circadian Rhythm; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Imaging, Three-Dimensional; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Young Adult | 2011 |
Selectivity sequences in a model calcium channel: role of electrostatic field strength.
Topics: Aspartic Acid; Binding Sites; Calcium Channels; Cations; Electrochemistry; Glutamic Acid; Ion Channel Gating; Models, Biological; Oxygen; Permeability; Static Electricity; Thermodynamics | 2011 |
Glutamate level detection by magnetic resonance spectroscopy in patients with post-stroke depression.
Topics: Aged; Aspartic Acid; Brain; Brain Mapping; Creatine; Depression; Female; Glutamic Acid; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Psychiatric Status Rating Scales; Stroke | 2012 |
Quantitative proton magnetic resonance spectroscopy of human precentral gyrus and hippocampus. Absolute concentrations of metabolites.
Topics: Adult; Aspartic Acid; Creatine; Female; Glutamic Acid; Gyrus Cinguli; Hippocampus; Humans; Linear Models; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Software; Young Adult | 2011 |
Long term antipsychotic treatment does not alter metabolite concentrations in rat striatum: an in vivo magnetic resonance spectroscopy study.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Aspartic Acid; Choline; Clozapine; Corpus Striatum; Creatine; Dose-Response Relationship, Drug; Glutamic Acid; Haloperidol; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley | 2011 |
Isoleucine 259 and isoleucine 260 residues in Streptococcus gordonii soluble inorganic pyrophosphatase play an important role in enzyme activity.
Topics: Aspartic Acid; Binding Sites; Catalysis; Catalytic Domain; Glutamic Acid; Inorganic Pyrophosphatase; Isoleucine; Mutagenesis, Site-Directed; Streptococcus gordonii; Valine | 2011 |
Glutamate release through connexin 43 by cultured astrocytes in a stimulated hypertonicity model.
Topics: Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Cells, Cultured; Chelating Agents; Connexin 43; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Extracellular Fluid; Glial Fibrillary Acidic Protein; Glutamic Acid; Hypertonic Solutions; Hypothalamus; Osmosis; Rats; Rats, Sprague-Dawley; Time Factors | 2011 |
The role of conserved Glu residue on cyclotide stability and activity: a structural and functional study of kalata B12, a naturally occurring Glu to Asp mutant.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Conserved Sequence; Cyclotides; Glutamic Acid; Molecular Sequence Data; Plant Proteins; Protein Stability; Protein Structure, Tertiary; Rubiaceae; Structure-Activity Relationship | 2011 |
Evidence of the participation of remote residues in the catalytic activity of Co-type nitrile hydratase from Pseudomonas putida.
Topics: Aspartic Acid; Binding Sites; Catalysis; Glutamic Acid; Histidine; Hydro-Lyases; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Secondary; Pseudomonas putida | 2011 |
A QM/QM investigation of the hUNG2 reaction surface: the untold tale of a catalytic residue.
Topics: Asparagine; Aspartic Acid; Catalysis; Catalytic Domain; Computer Simulation; DNA Mutational Analysis; Glutamic Acid; Histidine; Humans; Models, Molecular; Proline; Protons; Quantum Theory; Static Electricity; Surface Properties; Uracil-DNA Glycosidase; Water | 2011 |
Simple physics-based analytical formulas for the potentials of mean force of the interaction of amino-acid side chains in water. VI. Oppositely charged side chains.
Topics: Amino Acids; Arginine; Aspartic Acid; Glutamic Acid; Lysine; Molecular Dynamics Simulation; Proteins; Water | 2011 |
Simple physics-based analytical formulas for the potentials of mean force of the interaction of amino-acid side chains in water. V. Like-charged side chains.
Topics: Amino Acids; Arginine; Aspartic Acid; Glutamic Acid; Lysine; Models, Theoretical; Molecular Dynamics Simulation; Protein Folding; Proteins; Water | 2011 |
Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Creatine; Female; Genetic Association Studies; Genotype; Glutamic Acid; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memory; Methionine; Middle Aged; Multivariate Analysis; Polymorphism, Single Nucleotide; Protons; Schizophrenia; Valine; Verbal Learning | 2012 |
Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Extracellular Fluid; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Male; Microdialysis; Models, Biological; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic; Tritium | 2011 |
Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Ginkgo biloba; Ginkgolides; Glutamic Acid; Glycine; Infarction, Middle Cerebral Artery; Lactones; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2011 |
[2,4-(13)C]β-hydroxybutyrate metabolism in astrocytes and C6 glioblastoma cells.
Topics: 3-Hydroxybutyric Acid; Animals; Aspartic Acid; Astrocytes; Brain Neoplasms; Citric Acid Cycle; Diet, Ketogenic; Glioblastoma; Glucose; Glutamic Acid; Glutamine; Humans; Ketone Bodies; Lactic Acid; Mice; Tumor Cells, Cultured | 2011 |
Idebenone inhibition of glutamate release from rat cerebral cortex nerve endings by suppression of voltage-dependent calcium influx and protein kinase A.
Topics: 4-Aminopyridine; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Carbazoles; Cerebral Cortex; Clonazepam; Cyclic AMP-Dependent Protein Kinases; Dantrolene; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Indoles; Isoquinolines; Macrolides; Male; Maleimides; Membrane Potentials; Nerve Endings; omega-Conotoxins; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Sodium-Calcium Exchanger; Sulfonamides; Synaptosomes; Thiazepines; Ubiquinone | 2011 |
Free fatty acids as inducers and regulators of uncoupling of oxidative phosphorylation in liver mitochondria with participation of ADP/ATP- and aspartate/glutamate-antiporter.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antiporters; Aspartic Acid; Atractyloside; Cell Respiration; Fatty Acids, Nonesterified; Glutamic Acid; Hydrophobic and Hydrophilic Interactions; Mitochondria, Liver; Oxidative Phosphorylation; Rats; Uncoupling Agents | 2011 |
Role of Asp187 and Gln190 in the Na+/proline symporter (PutP) of Escherichia coli.
Topics: Amino Acid Transport Systems, Neutral; Aspartic Acid; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Models, Molecular; Symporters | 2011 |
Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Bone Marrow Transplantation; Cell Transformation, Neoplastic; Female; Gene Dosage; Genes, ras; Glutamic Acid; Hematologic Neoplasms; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Oncogenes; Organ Specificity | 2011 |
Identification of novel mammalian phospholipids containing threonine, aspartate, and glutamate as the base moiety.
Topics: Animals; Aspartic Acid; Cerebrum; Chromatography, High Pressure Liquid; Glutamic Acid; Glycerophospholipids; Liver; Rats; Spectrometry, Mass, Electrospray Ionization; Swine; Tandem Mass Spectrometry; Threonine | 2011 |
Grey matter and social functioning correlates of glutamatergic metabolite loss in schizophrenia.
Topics: Activities of Daily Living; Adolescent; Adult; Analysis of Variance; Antipsychotic Agents; Aspartic Acid; Brain Mapping; Case-Control Studies; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Social Participation; Thalamus; Time Factors | 2011 |
Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth.
Topics: Animals; Aspartic Acid; Base Sequence; Carbon; Citric Acid Cycle; DNA Primers; Fermentation; Gas Chromatography-Mass Spectrometry; Glucose; Glutamic Acid; Leishmania mexicana; Magnetic Resonance Spectroscopy; Succinic Acid | 2011 |
Desynchronization of multivesicular release enhances Purkinje cell output.
Topics: Action Potentials; Animals; Animals, Newborn; Aspartic Acid; Biophysical Phenomena; Calcium; Cerebellum; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; Linear Models; Mice; Nerve Fibers; Nerve Net; Patch-Clamp Techniques; Purkinje Cells; Quinoxalines; Strontium; Synapses; Time Factors | 2011 |
Transcranial direct current stimulation (tDCS) produces localized and specific alterations in neurochemistry: a ¹H magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Brain; Cerebrum; Dipeptides; Electric Stimulation; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Young Adult | 2011 |
Rare copy number deletions predict individual variation in human brain metabolite concentrations in individuals with alcohol use disorders.
Topics: Adult; Alcohol-Related Disorders; Aspartic Acid; Creatine; DNA Copy Number Variations; Female; Glutamic Acid; Glycerylphosphorylcholine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phosphocreatine; Phosphorylcholine; Protons | 2011 |
Neurosteroid allopregnanolone regulates EAAC1-mediated glutamate uptake and triggers actin changes in Schwann cells.
Topics: Actins; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport, Active; Excitatory Amino Acid Transporter 3; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Models, Neurological; Pregnanolone; Rats; RNA, Messenger; Schwann Cells; Up-Regulation | 2012 |
Cortical substrate oxidation during hyperketonemia in the fasted anesthetized rat in vivo.
Topics: Algorithms; Amino Acids; Anesthesia; Animals; Aspartic Acid; Astrocytes; Cerebral Cortex; Citric Acid Cycle; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Hydroxybutyrates; Ketone Bodies; Ketones; Magnetic Resonance Spectroscopy; Male; Neurons; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 2011 |
Closed traumatic brain injury model in sheep mimicking high-velocity, closed head trauma in humans.
Topics: Animals; Aspartic Acid; Brain; Brain Injuries; Carbon Dioxide; Disease Models, Animal; Electron Spin Resonance Spectroscopy; gamma-Aminobutyric Acid; Glutamic Acid; Head Injuries, Closed; Humans; Image Processing, Computer-Assisted; Intracranial Pressure; Magnetic Resonance Imaging; Oxygen Consumption; Sheep; Sheep, Domestic | 2011 |
Measurement of transverse relaxation times of J-coupled metabolites in the human visual cortex at 4 T.
Topics: Adult; Aspartic Acid; Choline; Creatine; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Signal Processing, Computer-Assisted; Taurine; Visual Cortex | 2012 |
Physiological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica neurons.
Topics: Action Potentials; Animals; Aplysia; Aspartic Acid; Calcium; Cations; Dose-Response Relationship, Drug; Excitatory Amino Acids; Ganglia, Invertebrate; Glutamic Acid; Ion Channel Gating; Ion Channels; Magnesium; Meglumine; Neurons; Patch-Clamp Techniques; Potassium; Receptors, Ionotropic Glutamate; Sodium; Stereoisomerism | 2011 |
Increased excitatory amino acid transport into murine prion protein knockout astrocytes cultured in vitro.
Topics: Animals; Aspartic Acid; Astrocytes; Blotting, Western; Cell Survival; Cells, Cultured; Coculture Techniques; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Flow Cytometry; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Prions; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sodium | 2011 |
High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice.
Topics: Animals; Aspartic Acid; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Models, Biological; Neostriatum; Neurochemistry; Taurine; Time Factors | 2012 |
Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Blotting, Western; Calorimetry; Crystallography, X-Ray; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Glutamic Acid; Humans; Methionine; Microscopy, Electron, Transmission; Models, Molecular; Molecular Sequence Data; Mutation; Peptide Fragments; Phenylalanine; Protein Binding; Protein Multimerization; Protein Structure, Tertiary; Sequence Homology, Amino Acid | 2011 |
Downregulation of glutamine synthetase via GLAST suppression induces retinal axonal swelling in a rat ex vivo hydrostatic pressure model.
Topics: Animals; Aspartic Acid; Axons; Blotting, Western; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Transporter 1; Fluorescent Antibody Technique, Indirect; Glutamate-Ammonia Ligase; Glutamic Acid; Hydrostatic Pressure; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley; Retinal Degeneration; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Functional characterization of vesicular excitatory amino acid transport by human sialin.
Topics: Animals; Aspartic Acid; Baculoviridae; Biological Transport, Active; DNA, Complementary; Glutamic Acid; Humans; Liposomes; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutation; Organic Anion Transporters; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sialic Acid Storage Disease; Symporters; Vesicular Biogenic Amine Transport Proteins | 2011 |
Contributions of counter-charge in a potassium channel voltage-sensor domain.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Glutamic Acid; Ion Channel Gating; Membrane Potentials; Molecular Sequence Data; Potassium Channels, Voltage-Gated; Static Electricity; Xenopus | 2011 |
Homeostatic regulation of glutamate neurotransmission in primary neuronal cultures.
Topics: Amino Acid Transport System X-AG; Aniline Compounds; Animals; Aspartic Acid; Biological Transport, Active; Brain; Calcium Signaling; Dizocilpine Maleate; Embryo, Mammalian; Female; Fluorescent Dyes; Glutamic Acid; Homeostasis; Mice; Neurons; Neurotransmitter Agents; Pregnancy; Primary Cell Culture; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Xanthenes | 2011 |
Selective observation of Asp and Glu resonances in (13)CO detected experiments.
Topics: Aspartic Acid; Carbon Isotopes; Glutamic Acid; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Ubiquitin | 2011 |
Peptide ligations accelerated by N-terminal aspartate and glutamate residues.
Topics: Aspartic Acid; Catalysis; Esters; Exenatide; Glutamic Acid; Hypoglycemic Agents; Molecular Structure; Peptides; Stereoisomerism; Sulfhydryl Compounds; Venoms | 2011 |
Retinal metabolic changes in an experimental model of optic nerve transection by ex vivo 1H magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Axotomy; Creatine; Female; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamic Acid; Magnetic Resonance Spectroscopy; Optic Nerve Injuries; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Taurine | 2011 |
T2 measurement of J-coupled metabolites in the human brain at 3T.
Topics: Adult; Aspartic Acid; Brain; Creatinine; Glutamic Acid; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution | 2012 |
Changes of amino acid concentrations in the rat vestibular nuclei after midline lesions.
Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Rats; Rats, Sprague-Dawley; Taurine; Vestibular Nuclei | 2011 |
Signaling through EAAT-1/GLAST in cultured Bergmann glia cells.
Topics: Animals; Aspartic Acid; Calcium; Cations, Divalent; Chick Embryo; Chickens; Excitatory Amino Acid Transporter 1; Glutamic Acid; Neuroglia; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Signal Transduction; TOR Serine-Threonine Kinases | 2011 |
2-(2-Pyridyl) benzimidazole based Co(II) complex as an efficient fluorescent probe for trace level determination of aspartic and glutamic acid in aqueous solution: a displacement approach.
Topics: Aspartic Acid; Benzimidazoles; Cobalt; Fluorescent Dyes; Glutamic Acid; Models, Molecular; Molecular Structure; Solutions | 2011 |
Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport.
Topics: Amiloride; Analysis of Variance; Animals; Animals, Newborn; Arthropod Proteins; Aspartic Acid; Biological Transport; Biophysical Phenomena; Brain; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cations; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Postsynaptic Potentials; Gluconates; Glutamic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Ionophores; Membrane Potential, Mitochondrial; Monensin; Oligopeptides; Potassium; Presynaptic Terminals; Radionuclide Imaging; Rats; Rats, Wistar; Sodium Isotopes; Synapses; Synaptic Vesicles; Synaptosomes; Tritium; Vesicular Glutamate Transport Proteins | 2011 |
Asp- and Glu-specific novel dipeptidyl peptidase 11 of Porphyromonas gingivalis ensures utilization of proteinaceous energy sources.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Cloning, Molecular; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Gene Expression Regulation, Bacterial; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Polymerase Chain Reaction; Porphyromonas gingivalis; Protein Structure, Tertiary; Proteins; Recombinant Proteins; Sequence Homology, Amino Acid | 2011 |
Determination of the effects of eNOS gene polymorphisms (T-786C and Glu298Asp) on nitric oxide levels in a methylmercury-exposed population.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Cardiovascular Diseases; Female; Glutamic Acid; Humans; Male; Mercury; Methylmercury Compounds; Middle Aged; Models, Statistical; Multivariate Analysis; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Polymorphism, Single Nucleotide; Risk Factors; Seafood | 2011 |
Brain glutamate levels are decreased in Alzheimer's disease: a magnetic resonance spectroscopy study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Creatine; Cross-Sectional Studies; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Severity of Illness Index | 2011 |
The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate.
Topics: Amino Acid Sequence; Animals; Apoptosis; Aspartic Acid; Caspase 6; Caspase 7; Catalytic Domain; Down-Regulation; Glutamic Acid; HEK293 Cells; Humans; Jurkat Cells; K562 Cells; Molecular Sequence Data; Mutagenesis, Site-Directed; Rabbits; Signal Transduction; Substrate Specificity; Telomerase | 2011 |
Pseudohyperphosphorylation has differential effects on polymerization and function of tau isoforms.
Topics: Amino Acid Substitution; Arachidonic Acid; Aspartic Acid; Biopolymers; Glutamic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Mutagenesis, Site-Directed; Phosphorylation; Protein Isoforms; Serine; tau Proteins; Tauopathies; Threonine | 2011 |
N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development.
Topics: Acetylcysteine; Alanine; Animals; Aspartic Acid; Cerebral Cortex; Disease Models, Animal; Free Radical Scavengers; Glutamate-Cysteine Ligase; Glutamic Acid; Glutamine; Glutathione; Inositol; Lactic Acid; Longitudinal Studies; Magnetic Resonance Spectroscopy; Mice; Mice, Knockout; Schizophrenia | 2012 |
Decreased benzodiazepine receptor and increased GABA level in cortical tubers in tuberous sclerosis complex.
Topics: Aspartic Acid; Brain; Case-Control Studies; Child; Child, Preschool; Female; Flumazenil; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Iodine Radioisotopes; Magnetic Resonance Spectroscopy; Male; Protons; Radiopharmaceuticals; Receptors, GABA-A; Tomography, Emission-Computed, Single-Photon; Tuberous Sclerosis | 2012 |
Role of charged residues in stabilization of Pyrococcus horikoshii CutA1, which has a denaturation temperature of nearly 150 °C.
Topics: Amino Acid Substitution; Archaeal Proteins; Aspartic Acid; Escherichia coli; Glutamic Acid; Hot Temperature; Protein Conformation; Protein Denaturation; Protein Stability; Pyrococcus horikoshii; Thermodynamics | 2012 |
Comparison of quantitative performance of three fluorescence labels in CE/LIF analysis of aspartate and glutamate in brain microdialysate.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Aspartic Acid; Brain Chemistry; Chickens; Electrophoresis, Capillary; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescent Dyes; Glutamic Acid; Microdialysis; Reproducibility of Results; Spectrometry, Fluorescence; Succinimides | 2011 |
Administration of thimerosal to infant rats increases overflow of glutamate and aspartate in the prefrontal cortex: protective role of dehydroepiandrosterone sulfate.
Topics: Animals; Animals, Newborn; Aspartic Acid; Chromatography, High Pressure Liquid; Dehydroepiandrosterone Sulfate; Electrochemical Techniques; Female; Glutamic Acid; Male; Microdialysis; Prefrontal Cortex; Pregnancy; Rats; Rats, Wistar; Thimerosal | 2012 |
Conventional and advanced magnetic resonance imaging in tumefactive demyelination.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Mapping; Child; Choline; Contrast Media; Demyelinating Diseases; Diffusion Magnetic Resonance Imaging; Female; Follow-Up Studies; Gadolinium DTPA; Glutamic Acid; Glutamine; Humans; Image Enhancement; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Young Adult | 2011 |
Rat brain slices oxidize glucose at high rates: a (13)C NMR study.
Topics: Acetates; Anesthesia; Anesthetics; Animals; Aspartic Acid; Brain; Carbon Isotopes; gamma-Aminobutyric Acid; Glucose; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Lactic Acid; Magnetic Resonance Spectroscopy; Pyruvic Acid; Rats; Rats, Wistar | 2011 |
Glutamate spillover promotes the generation of NMDA spikes.
Topics: Action Potentials; Animals; Animals, Newborn; Aspartic Acid; Biophysics; Calcium; Calcium Channel Blockers; Calcium Signaling; Chelating Agents; Dendrites; Drug Synergism; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; In Vitro Techniques; Indoles; Male; Mice; N-Methylaspartate; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Quinoxalines; Statistics, Nonparametric | 2011 |
Protonation states of important acidic residues in the central Ca²⁺ ion binding sites of the Ca²⁺-ATPase: a molecular modeling study.
Topics: Amino Acids, Acidic; Animals; Aspartic Acid; Binding Sites; Calcium; Chemical Phenomena; Databases, Protein; Enzyme Stability; Glutamic Acid; Kinetics; Lipid Bilayers; Membrane Fluidity; Models, Molecular; Molecular Dynamics Simulation; Phosphatidylcholines; Potassium; Protein Conformation; Protons; Rabbits; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2011 |
Metabolite detection of pancreatic carcinoma by in vivo proton MR spectroscopy at 3T: initial results.
Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Choline; Dipeptides; Fatty Acids, Unsaturated; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pancreatic Neoplasms; Software | 2012 |
[Influence of 1, 2-dichloroethane on open field behavior and levels of neurotransmitters in brain of mice].
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Ethylene Dichlorides; Female; gamma-Aminobutyric Acid; Glutamic Acid; Mice; Mice, Inbred Strains; Neurotransmitter Agents | 2011 |
Free energy simulations of ligand binding to the aspartate transporter Glt(Ph).
Topics: Amino Acid Transport System X-AG; Archaeal Proteins; Aspartic Acid; Binding Sites; Computer Simulation; Crystallography, X-Ray; Glutamic Acid; Ligands; Models, Molecular; Protein Binding; Pyrococcus horikoshii; Sodium; Thermodynamics | 2011 |
Benzimidazole conjugate of 1,1'-thiobis(2-naphthol) as switch-on fluorescence receptor for Ag+ and the complex as secondary recognition ensemble toward Cys, Asp, and Glu in aqueous methanolic solution: synthesis, characterization, ion and amino acid recog
Topics: Amino Acids; Aspartic Acid; Benzimidazoles; Cysteine; Fluorescent Dyes; Glutamic Acid; Ions; Magnetic Resonance Spectroscopy; Methanol; Silver; Solutions; Spectrophotometry, Ultraviolet; Water | 2012 |
Glutamate carboxypeptidase II gene polymorphisms and neural tube defects in a high-risk Chinese population.
Topics: Adult; Anencephaly; Asian People; Aspartic Acid; Case-Control Studies; China; Dipeptides; Encephalocele; Female; Folic Acid; Gene Frequency; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Neural Tube Defects; Polymorphism, Genetic; Risk Factors; Spinal Dysraphism; Young Adult | 2012 |
N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI).
Topics: Aged; Alzheimer Disease; Aspartic Acid; Choline; Cognitive Dysfunction; Disease Progression; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Temporal Lobe | 2011 |
The effect of the Asp175Asn and Glu180Gly TPM1 mutations on actin-myosin interaction during the ATPase cycle.
Topics: Actins; Actomyosin; Adenosine Triphosphatases; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Cardiomyopathy, Hypertrophic; Fluorescent Dyes; Glutamic Acid; Glycine; Humans; Muscle Contraction; Mutation; Myosin Subfragments; Naphthalenesulfonates; Peptide Fragments; Protein Structure, Secondary; Rabbits; Spectrometry, Fluorescence; Tropomyosin | 2012 |
Hypothyroidism reduces glutamate-synaptic release by ouabain depolarization in rat CA3-hippocampal region.
Topics: Analysis of Variance; Animals; Antithyroid Agents; Aspartic Acid; CA3 Region, Hippocampal; Drug Interactions; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Hypothyroidism; Male; Methimazole; Microdialysis; Neurotransmitter Uptake Inhibitors; Ouabain; Rats; Rats, Wistar; Synapses; Thyroxine | 2012 |
Metabolic gray matter changes of adolescents with anorexia nervosa in combined MR proton and phosphorus spectroscopy.
Topics: Adolescent; Analysis of Variance; Anorexia Nervosa; Aspartic Acid; Brain; Case-Control Studies; Child; Choline; Creatine; Female; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Phosphorus; Regression Analysis | 2012 |
Sex difference in stress-induced enhancement of hippocampal CA1 long-term depression during puberty.
Topics: Adrenalectomy; Androgens; Animals; Animals, Newborn; Aspartic Acid; CA1 Region, Hippocampal; Corticosterone; Dexamethasone; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glucocorticoids; Glutamic Acid; In Vitro Techniques; Long-Term Synaptic Depression; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Ovariectomy; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sex Characteristics; Statistics, Nonparametric; Stress, Psychological; Synaptosomes; Testosterone; Valine | 2012 |
Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model.
Topics: Animals; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Diabetes Mellitus, Type 2; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glycogen; Glycogen Phosphorylase; Homeostasis; Indoles; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Phenylbutyrates; Pyruvate Carboxylase; Pyruvate Dehydrogenase Complex; Rats; Rats, Sprague-Dawley; Rats, Zucker; Synaptic Transmission | 2012 |
Dual effect of beta-amyloid on α7 and α4β2 nicotinic receptors controlling the release of glutamate, aspartate and GABA in rat hippocampus.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; Immunohistochemistry; Male; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Potassium; Rats; Rats, Wistar; Receptors, Nicotinic; Time Factors; Veratridine | 2012 |
Electrostatic contribution of surface charge residues to the stability of a thermophilic protein: benchmarking experimental and predicted pKa values.
Topics: Archaeal Proteins; Aspartic Acid; Benchmarking; Computational Biology; Crystallography, X-Ray; Glutamic Acid; Hot Temperature; Hydrogen-Ion Concentration; Models, Molecular; Mutation; Protein Folding; Protein Stability; Protein Unfolding; Ribosomal Proteins; Static Electricity; Surface Properties; Thermococcus; Thermodynamics | 2012 |
Gender-dependent behavioural impairment and brain metabolites in young adult rats after short term exposure to lead acetate.
Topics: Animals; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; Glutamic Acid; Glutamine; Inositol; Magnetic Resonance Spectroscopy; Male; Maze Learning; Memory; Motor Activity; Organometallic Compounds; Psychomotor Performance; Rats; Rats, Wistar; Recognition, Psychology; Sex Factors | 2012 |
The accessibility in the external part of the TM5 of the glutamate transporter EAAT1 is conformationally sensitive during the transport cycle.
Topics: Aspartic Acid; Binding Sites; Biological Transport; Excitatory Amino Acid Transporter 1; Glutamic Acid; HeLa Cells; Humans; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Folding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Protein Transport; Tritium | 2012 |
Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Cells, Cultured; Glutamic Acid; Male; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; Neuroglia; Rats; Rats, Wistar; Receptor, Adenosine A2A | 2012 |
Synaptic vesicles are capable of synthesizing the VGLUT substrate glutamate from α-ketoglutarate for vesicular loading.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Blotting, Western; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; In Vitro Techniques; Indicators and Reagents; Ketoglutaric Acids; Male; Mitochondria; Proton-Translocating ATPases; Rats; Subcellular Fractions; Synaptic Vesicles; Synaptosomes; Vesicular Transport Proteins | 2012 |
Pannexin 1 forms an anion-selective channel.
Topics: Anions; Aspartic Acid; Cell Line; Cell Membrane Permeability; Chlorides; Connexins; Glutamic Acid; HEK293 Cells; Humans; Ion Channels; Nerve Tissue Proteins; Voltage-Dependent Anion Channels | 2012 |
Asparagine and aspartic acid concentrations in bone marrow versus peripheral blood during Berlin-Frankfurt-Münster-based induction therapy for childhood acute lymphoblastic leukemia.
Topics: Adolescent; Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Aspartic Acid; Bone Marrow; Child; Child, Preschool; Daunorubicin; Drug Administration Schedule; Female; Glutamic Acid; Glutamine; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Time Factors; Treatment Outcome; Vincristine | 2012 |
σ-1 Receptor agonist SKF10047 inhibits glutamate release in rat cerebral cortex nerve endings.
Topics: 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, N-Type; Cerebral Cortex; Cytosol; Glutamic Acid; Macrolides; Male; Membrane Potentials; Mitochondria; Nerve Endings; Phenazocine; Phosphorylation; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, sigma; Ryanodine Receptor Calcium Release Channel; Sigma-1 Receptor; Sodium-Calcium Exchanger; Vesicular Transport Proteins | 2012 |
Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors.
Topics: Alanine; Animals; Aspartic Acid; Ethanol; Female; Glutamic Acid; Glycine; Humans; Ion Channel Gating; Ion Channels; Mutation; Oocytes; Protein Binding; Protein Structure, Tertiary; Receptors, Glycine; Static Electricity; Xenopus laevis | 2012 |
Trans-spinal direct current enhances corticospinal output and stimulation-evoked release of glutamate analog, D-2,3-³H-aspartic acid.
Topics: Animals; Aspartic Acid; Behavior, Animal; Calcium; Cerebral Cortex; Disease Models, Animal; Electric Stimulation Therapy; Evoked Potentials, Motor; Female; Glutamic Acid; Long-Term Potentiation; Male; Mice; Motor Activity; Muscle Contraction; Muscle Strength; Muscle, Skeletal; Pyramidal Tracts; Spinal Cord Injuries; Synaptic Transmission; Time Factors | 2012 |
[Effect of single-used borneol and combining it with diazepam on content of neurotransmitter in corpus striatum of rats].
Topics: Animals; Aspartic Acid; Blood-Brain Barrier; Camphanes; Corpus Striatum; Diazepam; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley | 2011 |
RANTES-mediated control of excitatory amino acid release in mouse spinal cord.
Topics: Animals; Aspartic Acid; Blotting, Western; Calcium; Cerebral Cortex; Chemokine CCL5; Chemokines; Cytoplasm; Excitatory Amino Acids; Exocytosis; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Neuroglia; Receptors, Chemokine; Signal Transduction; Spinal Cord; Synaptosomes | 2012 |
In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate.
Topics: Amino Acids; Animals; Aspartic Acid; Astrocytes; Biological Transport; Blood-Brain Barrier; Brain; Cattle; Cell Polarity; Cells, Cultured; Electric Impedance; Endothelial Cells; Glial Fibrillary Acidic Protein; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Mannitol; Rats; RNA, Messenger; Sodium; Tritium | 2012 |
The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response.
Topics: Adaptor Proteins, Signal Transducing; Amidohydrolases; Amino Acid Sequence; Animals; Aspartic Acid; B-Cell CLL-Lymphoma 10 Protein; Biocatalysis; Caspases; Catalytic Domain; Crystallography, X-Ray; Cysteine; Diglycerides; DNA Mutational Analysis; Dysentery, Bacillary; Glutamic Acid; Glutamine; HEK293 Cells; HeLa Cells; Histidine; Humans; Immunity, Innate; Inflammation; Mice; Models, Molecular; Molecular Sequence Data; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; Neoplasm Proteins; NF-kappa B; Shigella flexneri; TNF Receptor-Associated Factor 6; Ubiquitin-Conjugating Enzymes; Virulence Factors | 2012 |
Phase-adjusted echo time (PATE)-averaging 1 H MRS: application for improved glutamine quantification at 2.89 T.
Topics: Aspartic Acid; Computer Simulation; Creatinine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Protons; Signal Processing, Computer-Assisted; Time Factors; Young Adult | 2012 |
Chronic nicotine exposure selectively activates a carrier-mediated release of endogenous glutamate and aspartate from rat hippocampal synaptosomes.
Topics: Animals; Aspartic Acid; Carrier Proteins; Drug Administration Schedule; Glutamic Acid; Hippocampus; Male; Nicotine; Nicotinic Agonists; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Synaptosomes | 2012 |
NOx and N2O precursors from biomass pyrolysis: nitrogen transformation from amino acid.
Topics: Amino Acids; Aspartic Acid; Biomass; Glutamic Acid; Nitrates; Nitrites; Nitrogen; Nitrous Oxide; Phenylalanine; Temperature | 2012 |
Weight is an independent predictor of vascular injury in healthy volunteers with aspartate allele.
Topics: Adult; Aspartic Acid; Atherosclerosis; Body Weight; Brachial Artery; Carotid Artery Diseases; Carotid Intima-Media Thickness; Chi-Square Distribution; Endothelium, Vascular; Female; Gene Frequency; Genetic Predisposition to Disease; Glutamic Acid; Homozygote; Humans; Italy; Linear Models; Male; Multivariate Analysis; Nitric Oxide Synthase Type III; Obesity; Phenotype; Polymorphism, Genetic; Risk Assessment; Risk Factors; Vasodilation | 2012 |
Posterior insular molecular changes in myofascial pain.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain Chemistry; Case-Control Studies; Cerebral Cortex; Choline; Facial Pain; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Male; Neuroimaging; Pain Measurement; Pain Threshold; Temporomandibular Joint Dysfunction Syndrome; Young Adult | 2012 |
Improve the coverage for the analysis of phosphoproteome of HeLa cells by a tandem digestion approach.
Topics: Amino Acid Motifs; Amino Acid Sequence; Aspartic Acid; Binding Sites; Glutamic Acid; HeLa Cells; Humans; Mass Spectrometry; Molecular Sequence Data; Phosphopeptides; Phosphoproteins; Phosphorylation; Proteolysis; Proteomics; Sensitivity and Specificity; Serine Endopeptidases; Staphylococcus aureus; Substrate Specificity; Trypsin | 2012 |
Proton MR spectroscopy of central neurocytoma using short and long echo time: new proofs for the existence of glycine and glutamate.
Topics: Adolescent; Adult; Aspartic Acid; Cerebral Ventricle Neoplasms; Choline; Creatine; Female; Glutamic Acid; Glycine; Humans; Magnetic Resonance Spectroscopy; Male; Neurocytoma; Young Adult | 2012 |
Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease.
Topics: Adult; Alanine; Aspartic Acid; Biomarkers; Chromatography, High Pressure Liquid; Disease Progression; Female; Glutamic Acid; Humans; Jaundice; Ketone Bodies; Liver Diseases; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolomics; Middle Aged; Multivariate Analysis; Prognosis; Reproducibility of Results; Sensitivity and Specificity | 2012 |
Neutralizing aspartate 83 modifies substrate translocation of excitatory amino acid transporter 3 (EAAT3) glutamate transporters.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Excitatory Amino Acid Transporter 3; Glutamic Acid; Humans; Ion Channel Gating; Ion Transport; Models, Biological; Mutation, Missense; Xenopus laevis | 2012 |
Access to cyclic or branched peptides using bis(2-sulfanylethyl)amido side-chain derivatives of Asp and Glu.
Topics: Aspartic Acid; Disulfides; Glutamic Acid; Molecular Structure; Peptides; Peptides, Cyclic; Sulfhydryl Compounds | 2012 |
Biochemical characterization of a novel cycloisomaltooligosaccharide glucanotransferase from Paenibacillus sp. 598K.
Topics: Amino Acid Sequence; Aspartic Acid; Bacillus; Bacterial Proteins; Chromatography, High Pressure Liquid; Cyclodextrins; Dextrans; Enzyme Stability; Escherichia coli; Glucosyltransferases; Glutamic Acid; Hot Temperature; Isoenzymes; Molecular Sequence Data; Paenibacillus; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 2012 |
siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate.
Topics: Animals; Aspartic Acid; Astrocytes; Blotting, Western; Cells, Cultured; Chromatography, High Pressure Liquid; Gene Knockdown Techniques; Glutamate Dehydrogenase; Glutamic Acid; Mice; RNA, Small Interfering | 2012 |
Differential changes of extracellular aspartate and glutamate in the striatum of domestic chicken evoked by high potassium or distress: an in vivo microdialysis study.
Topics: Animals; Aspartic Acid; Chickens; Corpus Striatum; Glutamic Acid; Microdialysis; Potassium Chloride; Stress, Psychological; Tetrodotoxin | 2012 |
Unusual increase in lumbar network excitability of the rat spinal cord evoked by the PARP-1 inhibitor PJ-34 through inhibition of glutamate uptake.
Topics: Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Cell Count; Electrophysiological Phenomena; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Glutamic Acid; Immunohistochemistry; Locomotion; Lumbosacral Region; Nerve Net; Phenanthrenes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Wistar; Reflex; Spinal Cord; Synaptic Transmission | 2012 |
Modifications on the hydrogen bond network by mutations of Escherichia coli copper efflux oxidase affect the process of proton transfer to dioxygen leading to alterations of enzymatic activities.
Topics: Amino Acid Substitution; Aspartic Acid; Catalytic Domain; Copper; Electron Transport Complex IV; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Hydrogen Bonding; Mutation; Oxidoreductases; Oxygen; Protons | 2012 |
Role of side-edge site of sphingomyelinase from Bacillus cereus.
Topics: Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Bacillus cereus; Bacterial Proteins; Erythrocyte Membrane; Glutamic Acid; Magnesium; Molecular Sequence Data; Phenylalanine; Sphingomyelin Phosphodiesterase | 2012 |
A shift in the salt bridge interaction of residues D620 and E621 mediates the constitutive activation of Jak2-H538Q/K539L.
Topics: Amino Acid Motifs; Amino Acid Substitution; Animals; Arginine; Aspartic Acid; Catalytic Domain; Chlorocebus aethiops; COS Cells; Enzyme Activation; Gene Expression Regulation; Genes, Reporter; Glutamic Acid; Humans; Janus Kinase 2; Luciferases, Firefly; Lysine; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Signal Transduction; Thermodynamics | 2012 |
Evaluation of corpus geniculatum laterale and vitreous fluid by magnetic resonance spectroscopy in patients with glaucoma; a preliminary study.
Topics: Aged; Apoptosis; Aspartic Acid; Choline; Creatine; Female; Geniculate Bodies; Glaucoma, Open-Angle; Glutamic Acid; Glutamine; Gonioscopy; Humans; Intraocular Pressure; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Middle Aged; Tonometry, Ocular; Vitreous Body | 2012 |
Group I metabotropic glutamate autoreceptors induce abnormal glutamate exocytosis in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Autoreceptors; Calcium; Disease Models, Animal; Excitatory Amino Acid Antagonists; Exocytosis; Female; Glutamic Acid; Glycine; Humans; Inositol Phosphates; Lumbar Vertebrae; Male; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Synaptosomes | 2013 |
Brain metabolite alterations and cognitive dysfunction in early Huntington's disease.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Cognition Disorders; Female; Glutamic Acid; Humans; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Regression Analysis; Trinucleotide Repeat Expansion | 2012 |
Glutamate transporters and presynaptic metabotropic glutamate receptors protect neocortical Cajal-Retzius cells against over-excitation.
Topics: Amino Acids; Animals; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Mice; Mice, Inbred C57BL; Neocortex; Neural Inhibition; Neurons; Presynaptic Terminals; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2012 |
Understanding the drug resistance mechanism of hepatitis C virus NS3/4A to ITMN-191 due to R155K, A156V, D168A/E mutations: a computational study.
Topics: Alanine; Amino Acid Substitution; Antiviral Agents; Arginine; Aspartic Acid; Comprehension; Computational Biology; Cyclopropanes; Drug Resistance, Viral; Glutamic Acid; Hepacivirus; Isoindoles; Lactams; Lactams, Macrocyclic; Lysine; Models, Molecular; Molecular Dynamics Simulation; Mutation, Missense; Proline; Sulfonamides; Valine; Viral Nonstructural Proteins | 2012 |
Elucidation of neuroprotective role of endogenous GABA and energy metabolites middle cerebral artery occluded model in rats.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain; Disease Models, Animal; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Neuroprotective Agents; Pyruvates; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sodium-Potassium-Exchanging ATPase; Time Factors | 2012 |
A 9-year follow-up of a girl with pyridoxine (vitamin B6)-dependent seizures: magnetic resonance spectroscopy findings.
Topics: Adolescent; Anticonvulsants; Aspartic Acid; Biomarkers; Brain; Child; Creatinine; Disease Progression; Epilepsy; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Predictive Value of Tests; Pyridoxine; Treatment Outcome; Vitamin B Complex | 2012 |
Novel thiol- and thioether-containing amino acids: cystathionine and homocysteine families.
Topics: Aspartic Acid; Cystathionine; Glutamic Acid; Homocysteine; Molecular Structure | 2013 |
The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy.
Topics: Actins; Amino Acid Substitution; Asparagine; Aspartic Acid; Calcium; Cardiomyopathy, Hypertrophic; Glutamic Acid; Glycine; Humans; Microscopy, Electron; Models, Chemical; Molecular Dynamics Simulation; Mutation; Myosins; Protein Structure, Secondary; Tropomyosin | 2012 |
Regional decoupling of N-acetyl-aspartate and glutamate in schizophrenia.
Topics: Adult; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Female; Glutamic Acid; Hippocampus; Homeostasis; Humans; Magnetic Resonance Spectroscopy; Male; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 2012 |
Increased glutamate levels in the medial prefrontal cortex in patients with postpartum depression.
Topics: Adult; Aspartic Acid; Case-Control Studies; Creatine; Depression, Postpartum; Female; Glutamic Acid; Glycerylphosphorylcholine; Humans; Magnetic Resonance Spectroscopy; Phosphorylcholine; Prefrontal Cortex; Pregnancy; Time Factors; Young Adult | 2012 |
Glutamate transporter-dependent mTOR phosphorylation in Müller glia cells.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Calcimycin; Calcium; Cells, Cultured; Chick Embryo; D-Aspartic Acid; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Ependymoglial Cells; Excitatory Amino Acid Agents; Gene Expression Regulation; Glutamic Acid; Phosphorylation; Retina; Serine; Signal Transduction; TOR Serine-Threonine Kinases | 2012 |
Indirect effects of elevated body mass index on memory performance through altered cerebral metabolite concentrations.
Topics: Adult; Aspartic Acid; Biomarkers; Body Mass Index; Brain; Choline; Cognition Disorders; Creatine; Female; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Memory; Middle Aged; Neuropsychological Tests; Obesity; Protons | 2012 |
MRS study of meningeal hemangiopericytoma and edema: a comparison with meningothelial meningioma.
Topics: 3-Hydroxybutyric Acid; Alanine; Aspartic Acid; Brain Edema; Choline; Creatine; Glutamic Acid; Glutathione; Glycine; Hemangiopericytoma; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Meningeal Neoplasms; Meningioma | 2012 |
Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Choline; Creatine; Disease Models, Animal; Functional Neuroimaging; Glutamic Acid; Hippocampus; Inositol; Magnetic Resonance Spectroscopy; Maze Learning; Mice; Mice, Transgenic; Presenilin-1; Protons | 2012 |
Multimodal analysis of the hippocampus in schizophrenia using proton magnetic resonance spectroscopy and functional magnetic resonance imaging.
Topics: Adult; Analysis of Variance; Aspartic Acid; Creatine; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Oxygen; Protons; Schizophrenia; Young Adult | 2012 |
Effective improvement of D-phenylglycine aminotransferase solubility by protein crystal contact engineering.
Topics: Aspartic Acid; Circular Dichroism; Glutamic Acid; Hydrogen-Ion Concentration; Isoelectric Point; Models, Molecular; Mutation; Protein Conformation; Protein Engineering; Recombinant Proteins; Solubility; Temperature; Transaminases | 2012 |
Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disorders.
Topics: Adolescent; Adult; Aspartic Acid; Case Management; Combined Modality Therapy; Energy Metabolism; Female; Glutamic Acid; Glutathione; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Psychotic Disorders; Psychotropic Drugs; Reference Values; Young Adult | 2012 |
L-aspartate effects on single neurons and interactions with glutamate in striatal slice preparation from chicken brain.
Topics: Animals; Aspartic Acid; Chickens; Corpus Striatum; Excitatory Amino Acid Antagonists; Glutamic Acid; Neurons; Organ Culture Techniques; Patch-Clamp Techniques | 2012 |
Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Aspartic Acid; Calcium Signaling; Cells, Cultured; Female; Glucose; Glutamate Dehydrogenase; Glutamic Acid; Glutamine; Insulin; Insulin Secretion; Insulin-Secreting Cells; Leucine; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout | 2012 |
The glutamate aspartate transporter (GLAST) mediates L-glutamate-stimulated ascorbate-release via swelling-activated anion channels in cultured neonatal rodent astrocytes.
Topics: Animals; Animals, Newborn; Anions; Ascorbic Acid; Aspartic Acid; Astrocytes; Benzopyrans; Cell Size; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Glutamic Acid; Glycolates; Hypertonic Solutions; Hypotonic Solutions; Ion Channels; Mice; Mice, Inbred C57BL; Rats; Rats, Wistar | 2013 |
Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis.
Topics: Adult; Arginine; Aspartic Acid; Biomarkers; Brain; Cognition Disorders; Cross-Sectional Studies; Female; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Inositol; Liver Cirrhosis; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prospective Studies | 2013 |
Affinity purification and characterization of a seed lectin from Crotalaria medicaginea.
Topics: ABO Blood-Group System; Amino Acids; Animals; Asialoglycoproteins; Aspartic Acid; Calcium; Chromatography, Affinity; Crotalaria; Fetuins; Glutamic Acid; Hemagglutinins; Humans; Hydrogen-Ion Concentration; Ions; Lectins; Manganese; Neuraminidase; Rabbits; Rats; Seeds; Temperature | 2002 |
Residues PsaB Asp612 and PsaB Glu613 of photosystem I confer pH-dependent binding of plastocyanin and cytochrome c(6).
Topics: Aspartic Acid; Chlamydomonas reinhardtii; Cytochromes c6; Electron Transport; Glutamic Acid; Hydrogen-Ion Concentration; Photosystem I Protein Complex; Plastocyanin; Protein Binding | 2012 |
Asymmetric Michael additions of α-nitrocyclohexanone to aryl nitroalkenes catalyzed by natural amino acid-derived bifunctional thioureas.
Topics: Alkenes; Amino Acids; Aspartic Acid; Catalysis; Glutamic Acid; Molecular Structure; Nitro Compounds; Piperidines; Pyrrolidines; Stereoisomerism; Thiourea | 2012 |
Association between Glu298Asp/677C-T single nucleotide polymorphism in the eNOS/MTHRF gene and blood stasis syndrome of ischemic stroke.
Topics: Aged; Aspartic Acid; Base Sequence; Brain Ischemia; DNA Primers; Female; Glutamic Acid; Hemostasis; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nitric Oxide Synthase Type III; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Stroke | 2012 |
Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1 H MRS study.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Choline; Creatine; Disease Models, Animal; Female; Frontal Lobe; gamma-Aminobutyric Acid; Genotype; Glutamic Acid; Inositol; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Rats; Rats, Transgenic | 2012 |
Metabolic maturation of the human brain from birth through adolescence: insights from in vivo magnetic resonance spectroscopy.
Topics: Adolescent; Aspartic Acid; Brain; Brain Chemistry; Child; Child, Preschool; Choline; Creatine; Female; Glutamic Acid; Humans; Infant; Infant, Newborn; Inositol; Magnetic Resonance Spectroscopy; Male; Taurine | 2013 |
Parkin prevents cortical atrophy and Aβ-induced alterations of brain metabolism: ¹³C NMR and magnetic resonance imaging studies in AD models.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Atrophy; Brain; Carbon Isotopes; Carrier Proteins; Cell Cycle Proteins; Disease Models, Animal; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Eukaryotic Initiation Factors; Gene Knock-In Techniques; Genetic Vectors; Glial Fibrillary Acidic Protein; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Peptide Fragments; Phosphoproteins; Presenilin-1; Single-Blind Method; tau Proteins; TOR Serine-Threonine Kinases; Transcription Factors; Ubiquitin-Protein Ligases | 2012 |
Chiral separation and determination of excitatory amino acids in brain samples by CE-LIF using dual cyclodextrin system.
Topics: Animals; Aspartic Acid; Brain Chemistry; Chemistry Techniques, Analytical; Chickens; Cyclodextrins; Electrophoresis, Capillary; Excitatory Amino Acids; Glutamic Acid; Reproducibility of Results; Stereoisomerism; Time Factors | 2012 |
Differential NMR spectroscopy reactions of anterior/posterior and right/left insular subdivisions due to acute dental pain.
Topics: Acute Pain; Adult; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pain Threshold; Prospective Studies; Sampling Studies; Sensitivity and Specificity; Toothache; Young Adult | 2013 |
Multiple sensor array of Mn2+, Fe2+, Co2+, Ni2+, Cu2+, and Zn2+ complexes of a triazole linked imino-phenol based calix[4]arene conjugate for the selective recognition of Asp, Glu, Cys, and His.
Topics: Aspartic Acid; Calixarenes; Cysteine; Glutamic Acid; Histidine; Imines; Models, Molecular; Molecular Structure; Organometallic Compounds; Phenols; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Transition Elements; Triazoles | 2012 |
[Amino acids content in the blood serum of patients with multiple sclerosis].
Topics: Adult; Aspartic Acid; Chromatography, Ion Exchange; Female; Glutamic Acid; Glycine; Humans; Male; Multiple Sclerosis; Severity of Illness Index | 2012 |
Dual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Benzamides; Blotting, Western; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p21; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genes, ras; Glutamic Acid; Glycine; Humans; MAP Kinase Signaling System; Melanocytes; Melanoma; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-jun; RNA, Small Interfering; Transcription Factor AP-1; Transfection; Transplantation, Heterologous; Valine; Viral Vaccines | 2012 |
The structural analysis and the role of calcium binding site for thermal stability in mannanase.
Topics: Actinomycetales; Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; beta-Mannosidase; Binding Sites; Calcium; Calorimetry; Catalytic Domain; Circular Dichroism; Enzyme Stability; Glutamic Acid; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Species Specificity; Streptomyces; Temperature | 2012 |
Analysis of brain metabolism by proton magnetic resonance spectroscopy (1H-MRS) in attention-deficit/hyperactivity disorder suggests a generalized differential ontogenic pattern from controls.
Topics: Adolescent; Adult; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Brain; Case-Control Studies; Choline; Creatine; Female; Functional Neuroimaging; Glutamic Acid; Glutamine; Humans; Inositol; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Statistics, Nonparametric | 2012 |
Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes.
Topics: Aging; Animals; Aspartic Acid; Astrocytes; Brain; Cell Separation; Cells, Cultured; Cellular Senescence; Cytoplasm; Energy Metabolism; Female; Glutamic Acid; Lactic Acid; Male; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Membrane Transport Proteins; NAD; Nerve Tissue Proteins; Neurons; Oxidation-Reduction; Primary Cell Culture; Pyruvic Acid; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2012 |
Altered brain metabolism after whole body irradiation in mice: a preliminary in vivo 1H MRS study.
Topics: Animals; Aspartic Acid; Brain; Cerebral Cortex; Choline; Creatine; Glutamic Acid; Glutamine; Hippocampus; Hypothalamus; Inositol; Magnetic Resonance Spectroscopy; Male; Mice; Models, Neurological; Oxidative Stress; Phosphocreatine; Taurine; Thalamus; Time Factors; Tissue Distribution | 2013 |
Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis.
Topics: Analysis of Variance; Animals; Aspartic Acid; Cell Death; Choline O-Acetyltransferase; Cytoplasm; DNA-Binding Proteins; Embryo, Mammalian; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunoprecipitation; Neoplasm Proteins; Neurons; Phosphopyruvate Hydratase; Protein Binding; Rats; Repressor Proteins; Spinal Cord; Transfection; Ubiquitination | 2012 |
Glutamate modulates resting state activity in the perigenual anterior cingulate cortex - a combined fMRI-MRS study.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain Mapping; Conditioning, Operant; Creatine; Female; Glutamic Acid; Gyrus Cinguli; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Oxygen; Punishment; Regression Analysis; Rest; Reward; Young Adult | 2012 |
MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Brain Mapping; Choline; Creatine; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Neuroimaging; Presenilin-1; Tritium | 2013 |
Spectral editing of two-dimensional magic-angle-spinning solid-state NMR spectra for protein resonance assignment and structure determination.
Topics: Amino Acids; Aspartic Acid; Bacterial Proteins; Glutamic Acid; Models, Theoretical; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Proteins; Ubiquitin | 2012 |
The effects of excitatory amino acids and their transporters on function and structure of the distal retina in albino rabbits.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Electroretinography; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Glutamic Acid; Intravitreal Injections; Rabbits; Retina; Synaptic Transmission | 2012 |
Amygdalofugal axon terminals immunoreactive for L-aspartate or L-glutamate in the nucleus accumbens of rats and domestic chickens: a comparative electron microscopic immunocytochemical study combined with anterograde pathway tracing.
Topics: Amygdala; Animals; Aspartic Acid; Axons; Chickens; Female; Glutamic Acid; Immunohistochemistry; Male; Microscopy, Electron; Neural Pathways; Nucleus Accumbens; Rats; Rats, Wistar; Synapses | 2012 |
Adsorption of amino acids on the magnetite-(111)-surface: a force field study.
Topics: Adsorption; Amino Acids; Aspartic Acid; Ferrosoferric Oxide; Glutamic Acid; Glycine; Leucine; Magnetosomes; Magnetospirillum; Molecular Docking Simulation; Static Electricity; Thermodynamics | 2013 |
STAAR: statistical analysis of aromatic rings.
Topics: Aspartic Acid; Glutamic Acid; Phenylalanine; Proteins; Quantum Theory; Software | 2013 |
Dynamic control of selectivity in the ubiquitination pathway revealed by an ASP to GLU substitution in an intra-molecular salt-bridge network.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Computational Biology; Glutamic Acid; Humans; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Reproducibility of Results; Sequence Alignment; Static Electricity; Two-Hybrid System Techniques; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitination | 2012 |
Preoperative and postoperative 1H-MR spectroscopy changes in frontal deep white matter and the thalamus in idiopathic normal pressure hydrocephalus.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Case-Control Studies; Choline; Creatine; Female; Frontal Lobe; Functional Neuroimaging; Glutamic Acid; Humans; Hydrocephalus, Normal Pressure; Inositol; Lactic Acid; Lateral Ventricles; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Fibers, Myelinated; Postoperative Period; Preoperative Period; Thalamus | 2013 |
Psychiatric symptoms correlate with metabolic indices in the hippocampus and cingulate in patients with mitochondrial disorders.
Topics: Adult; Aged; Anxiety; Aspartic Acid; Case-Control Studies; Caudate Nucleus; Creatine; Female; Glutamic Acid; Glutamine; Glycerylphosphorylcholine; Gyrus Cinguli; Hippocampus; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mitochondrial Diseases; Psychiatric Status Rating Scales | 2012 |
Neurometabolite concentration and clinical features of chronic alcohol use: a proton magnetic resonance spectroscopy study.
Topics: Adult; Age Factors; Alcohol-Related Disorders; Aspartic Acid; Case-Control Studies; Cerebrospinal Fluid; Choline; Creatine; Female; Functional Neuroimaging; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Male; Middle Aged; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Phosphocreatine; Sex Factors | 2013 |
Reduced posterior cingulate glutamate measured by magnetic resonance spectroscopy in hyperthyroidism.
Topics: Adult; Aspartic Acid; Choline; Cognition Disorders; Creatine; Female; Glutamic Acid; Gyrus Cinguli; Humans; Hyperthyroidism; Magnetic Resonance Spectroscopy; Male; Young Adult | 2012 |
Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biophysics; Biotinylation; Cells, Cultured; Colforsin; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Postsynaptic Potentials; Flow Cytometry; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Indoles; Kainic Acid; Long-Term Potentiation; Male; Neurons; Protein Transport; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin; Valine | 2012 |
A prospective study of physician-observed concussion during a varsity university hockey season: metabolic changes in ice hockey players. Part 4 of 4.
Topics: Adult; Aspartic Acid; Athletic Injuries; Brain; Brain Concussion; Creatine; Creatinine; Female; Glutamic Acid; Hockey; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Physicians; Prospective Studies; Universities; Young Adult | 2012 |
Comparison and effects of acute lamotrigine treatment on extracellular excitatory amino acids in the hippocampus of PTZ-kindled epileptic and PTZ-induced status epilepticus rats.
Topics: Animals; Aspartic Acid; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kindling, Neurologic; Lamotrigine; Male; Neurotransmitter Agents; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Status Epilepticus; Triazines | 2013 |
Brain dynamic neurochemical changes in dystonic patients: a magnetic resonance spectroscopy study.
Topics: Adult; Aged; Aspartic Acid; Brain Chemistry; Data Interpretation, Statistical; Dystonia; Energy Metabolism; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Neostriatum; Neural Pathways; Somatosensory Cortex; Transcranial Magnetic Stimulation; Upper Extremity; Young Adult | 2013 |
L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the 'collusion' hypothesis for increased extracellular L-glutamate concentration in neuroinflammation.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Benzopyrans; Carbenoxolone; Cell Death; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Dose-Response Relationship, Drug; Down-Regulation; Excitatory Amino Acid Transporter 1; Extracellular Fluid; Gene Expression Regulation; Glutamic Acid; L-Lactate Dehydrogenase; Lipopolysaccharides; Microglia; Neurons; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Tetrazolium Salts; Thiazoles | 2012 |
Higher glutamate to glutamine ratios in occipital regions in women with migraine during the interictal state.
Topics: Adult; Analysis of Variance; Aspartic Acid; Case-Control Studies; Epilepsy; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Migraine Disorders; Occipital Lobe; Young Adult | 2013 |
Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive-compulsive disorder.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Choline; Cognitive Behavioral Therapy; Dipeptides; Follow-Up Studies; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurochemistry; Obsessive-Compulsive Disorder; Pilot Projects; Severity of Illness Index | 2013 |
[(1)H-MRS study of auditory cortex in patients with presbycusis].
Topics: Adult; Aged; Aspartic Acid; Auditory Cortex; Case-Control Studies; Choline; Creatine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Presbycusis; Young Adult | 2012 |
Longitudinal monitoring of sex-related in vivo metabolic changes in the brain of Alzheimer's disease transgenic mouse using magnetic resonance spectroscopy.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Aspartic Acid; Brain; Creatine; Disease Models, Animal; Female; Glutamic Acid; Humans; Iron; Linear Models; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Presenilin-1 | 2013 |
Longitudinal 1H MRS of rat forebrain from infancy to adulthood reveals adolescence as a distinctive phase of neurometabolite development.
Topics: Aging; Animals; Aspartic Acid; Dipeptides; Glutamic Acid; Inositol; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Prosencephalon; Rats; Rats, Sprague-Dawley; Taurine | 2013 |
Development and optimization of an integrated PDMS based-microdialysis microchip electrophoresis device with on-chip derivatization for continuous monitoring of primary amines.
Topics: Amines; Amino Acids; Aspartic Acid; Electrophoresis, Microchip; Glutamic Acid; Microdialysis; Naphthalenes | 2013 |
Assessment of brain metabolites change during visual sexual stimulation in healthy women using functional MR spectroscopy.
Topics: Adult; Analysis of Variance; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Erotica; Female; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Libido; Lipid Metabolism; Magnetic Resonance Spectroscopy; Middle Aged; Photic Stimulation; Sexual Behavior; Young Adult | 2013 |
Increase of extracellular glutamate concentration increases its oxidation and diminishes glucose oxidation in isolated mouse hippocampus: reversible by TFB-TBOA.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Extracellular Fluid; Glucose; Glutamic Acid; Hippocampus; Male; Mice; Neurons; Organ Culture Techniques; Oxidation-Reduction | 2013 |
Novel cell penetrating peptides with multiple motifs composed of RGD and its analogs.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid; Cell Line, Tumor; Cell-Penetrating Peptides; Gene Silencing; Glutamic Acid; Humans; Liposomes; Mice; Molecular Sequence Data; NIH 3T3 Cells; Oligopeptides; RNA, Small Interfering | 2013 |
Molecular determinants for functional differences between alanine-serine-cysteine transporter 1 and other glutamate transporter family members.
Topics: Amino Acid Substitution; Amino Acid Transport System ASC; Animals; Archaeal Proteins; Aspartic Acid; Binding Sites; Biological Transport; Cells, Cultured; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Membrane Potentials; Mutagenesis, Site-Directed; Serine; Substrate Specificity; Xenopus laevis | 2013 |
Spike-driven glutamate electrodiffusion triggers synaptic potentiation via a homer-dependent mGluR-NMDAR link.
Topics: Action Potentials; Animals; Animals, Newborn; Aspartic Acid; Biophysics; Carrier Proteins; Cerebellum; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Glutamic Acid; Green Fluorescent Proteins; Homer Scaffolding Proteins; Humans; In Vitro Techniques; Luminescent Proteins; Microscopy, Electron, Transmission; Models, Neurological; Monte Carlo Method; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Red Fluorescent Protein; RNA, Small Interfering; Statistics, Nonparametric; Synapses; Synapsins; Transfection | 2013 |
[Magnetic resonance spectroscopy of metabolic changes in mice brain after 2-deoxy-D-glucose injection].
Topics: Animals; Aspartic Acid; Brain; Choline; Deoxyglucose; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycolysis; Humans; Lipopolysaccharides; Magnetic Resonance Spectroscopy; Male; Mice; Neurodegenerative Diseases; Radiography | 2012 |
Neurochemical profile of patients with type 1 diabetes measured by ¹H-MRS at 4 T.
Topics: Adult; Aspartic Acid; Brain; Diabetes Mellitus, Type 1; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurotransmitter Agents; Occipital Lobe | 2013 |
Excitatory amino acids display compartmental disparity between plasma and synovial fluid in clinical arthropathies.
Topics: Adult; Aged; Arthritis; Aspartic Acid; Blood Chemical Analysis; Cadaver; Chromatography, High Pressure Liquid; Glutamic Acid; Humans; Joints; Middle Aged; Synovial Fluid | 2013 |
Chemical gradients within brain extracellular space measured using low flow push-pull perfusion sampling in vivo.
Topics: Acetylcholine; Animals; Aspartic Acid; Brain; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Microdialysis; Neurotransmitter Agents; Norepinephrine; Nucleus Accumbens; Perfusion; Rats; Red Nucleus; Serotonin; Ventral Tegmental Area | 2013 |
Hippocampal abnormalities of glutamate/glutamine, N-acetylaspartate and choline in patients with depression are related to past illness burden.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Cost of Illness; Cross-Sectional Studies; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged | 2013 |
Intramolecular proton transfer in channelrhodopsins.
Topics: Archaea; Aspartic Acid; Chlorophyta; Glutamic Acid; HEK293 Cells; Humans; Ion Channel Gating; Ion Transport; Light; Membrane Potentials; Mutation; Protons; Retinoids; Rhodopsins, Microbial | 2013 |
Biochemical correlates of neuropsychiatric illness in maple syrup urine disease.
Topics: Adolescent; Adult; Affect; Anxiety; Aspartic Acid; Attention; Brain; Case-Control Studies; Child; Child, Preschool; Creatine; Depression; Female; Glutamic Acid; Humans; Impulsive Behavior; Liver Transplantation; Male; Maple Syrup Urine Disease; Prevalence; Psychomotor Agitation; Risk; Young Adult | 2013 |
Critical role of the astrocyte for functional remodeling in contralateral hemisphere of somatosensory cortex after stroke.
Topics: Aminomethyltransferase; Analysis of Variance; Animals; Aspartic Acid; Astrocytes; Calcium; Disease Models, Animal; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Functional Laterality; Gene Expression Regulation; Glutamic Acid; Glycine; Male; Mice; Mice, Inbred C57BL; Microdialysis; Motor Activity; Neurons; Physical Stimulation; RNA, Messenger; Somatosensory Cortex; Stroke; Time Factors; Vibrissae | 2013 |
Dyslipidemia links obesity to early cerebral neurochemical alterations.
Topics: Adult; Aspartic Acid; Blood Glucose; Blood Pressure; Body Mass Index; Brain; Brain Diseases; Cholesterol, HDL; Choline; Creatine; Dyslipidemias; Female; Glutamic Acid; Humans; Inositol; Linear Models; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurochemistry; Obesity; Triglycerides | 2013 |
Effects of age and sex on the concentrations of glutamate and glutamine in the human brain.
Topics: Adult; Aging; Aspartic Acid; Choline; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurotransmitter Agents; Reproducibility of Results; Sensitivity and Specificity; Sex Factors; Young Adult | 2013 |
The stabilization effect of dielectric constant and acidic amino acids on arginine-arginine (Arg-Arg) pairings: database survey and computational studies.
Topics: Amino Acids, Acidic; Aspartic Acid; Carbon; Computational Biology; Databases, Protein; Dipeptides; Glutamic Acid; Kinetics; Solvents; Static Electricity; Thermodynamics | 2013 |
A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors.
Topics: Adult; Aspartic Acid; Brain Neoplasms; gamma-Aminobutyric Acid; Glioma; Glutamic Acid; Glutamine; Glutarates; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Spectroscopy; Middle Aged; Mutation; Phantoms, Imaging; Protons; Young Adult | 2013 |
Influence of the hippocampus on amino acid utilizing and cholinergic neurons within the nucleus accumbens is promoted by histamine via H₁ receptors.
Topics: Acetylcholine; Animals; Aspartic Acid; Cholinergic Neurons; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Histamine; Histamine H1 Antagonists; Male; Microelectrodes; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Histamine H1; Triprolidine | 2013 |
Progressive cerebral injury in the setting of chronic HIV infection and antiretroviral therapy.
Topics: Adult; AIDS Dementia Complex; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Aspartic Acid; Basal Ganglia; Cerebral Cortex; Choline; Cognition; Disease Progression; Female; Glutamic Acid; HIV; Humans; Inositol; Male; Middle Aged; Neuropsychological Tests | 2013 |
Increased concentrations of glutamate and glutamine in normal-appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans.
Topics: Adult; Aged; Aspartic Acid; Brain; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis | 2013 |
Stereoselective ribosylation of amino acids.
Topics: Adenosine Diphosphate Ribose; Amino Acids; Aspartic Acid; Glutamic Acid; Glycosylation; Molecular Structure; Ribose; Stereoisomerism | 2013 |
A pilot study of anterior cingulate cortex neurochemistry in adolescents with generalized anxiety disorder.
Topics: Adolescent; Anxiety Disorders; Aspartic Acid; Brain Chemistry; Case-Control Studies; Child; Creatine; Female; Glutamic Acid; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Pilot Projects | 2013 |
Proton magnetic resonance spectroscopy of the substantia nigra in schizophrenia.
Topics: Adult; Analysis of Variance; Aspartic Acid; Creatine; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Protons; Schizophrenia; Substantia Nigra; Young Adult | 2013 |
[Protective action of melatonin in experimental glaucoma in rats].
Topics: Animals; Antioxidants; Aspartic Acid; Chromatography, Ion Exchange; Epinephrine; gamma-Aminobutyric Acid; Glaucoma; Glutamic Acid; Glycine; Intraocular Pressure; Male; Melatonin; Neuroprotective Agents; Neurotransmitter Agents; Rats; Retina; Vitreous Body | 2013 |
Extrasynaptic targeting of NMDA receptors following D1 dopamine receptor activation and cocaine self-administration.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Cocaine; Cocaine-Related Disorders; Data Interpretation, Statistical; Dopamine Agonists; Dopamine Uptake Inhibitors; Extracellular Space; Glutamic Acid; Male; Nucleus Accumbens; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Self Administration; Synapses; Up-Regulation | 2013 |
An efficient chemical synthesis of carboxylate-isostere analogs of daptomycin.
Topics: Aspartic Acid; Carboxylic Acids; Chemistry Techniques, Synthetic; Daptomycin; Glutamic Acid | 2013 |
Surface modified fluorescent quantum dots with neurotransmitter ligands for potential targeting of cell signaling applications.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Adsorption; Aspartic Acid; Cadmium Compounds; Cells; Fluorescence; Glutamic Acid; Humans; Ligands; Light; Membranes; Neurotransmitter Agents; Particle Size; Quantum Dots; Scattering, Radiation; Signal Transduction; Solutions; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Static Electricity; Sulfides; Surface Properties; Thermodynamics | 2013 |
Brain metabolite alterations in young adults at familial high risk for schizophrenia using proton magnetic resonance spectroscopy.
Topics: Adolescent; Analysis of Variance; Aspartic Acid; Brain; Cognition Disorders; Family Health; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Schizophrenia; Young Adult | 2013 |
Microstructural organization of axons in the human corpus callosum quantified by diffusion-weighted magnetic resonance spectroscopy of N-acetylaspartate and post-mortem histology.
Topics: Anisotropy; Aspartic Acid; Axons; Corpus Callosum; Diffusion Tensor Imaging; Glutamic Acid; Healthy Volunteers; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Postmortem Changes | 2014 |
Neurochemical abnormalities in unmedicated bipolar depression and mania: a 2D 1H MRS investigation.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Brain; Creatine; Female; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Psychiatric Status Rating Scales; Tritium; Young Adult | 2013 |
Identifying the catalytic acid/base in GH29 α-L-fucosidase subfamilies.
Topics: alpha-L-Fucosidase; Aspartic Acid; Bacteroides; Catalysis; Glutamic Acid; Kinetics; Phylogeny; Substrate Specificity; Thermotoga maritima | 2013 |
Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function.
Topics: Analysis of Variance; Antipsychotic Agents; Aspartic Acid; Dihydroxyphenylalanine; Dopamine; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Positron-Emission Tomography; Protons; Schizophrenia | 2014 |
Umami evaluation in taste epithelium on microelectrode array by extracellular electrophysiological recording.
Topics: Animals; Aspartic Acid; Biosensing Techniques; Dose-Response Relationship, Drug; Electrophysiology; Epithelium; Glutamic Acid; Microelectrodes; Nucleotides; Rats; Rats, Sprague-Dawley; Sodium Glutamate; Taste; Taste Buds; Time Factors | 2013 |
Parkinson's disease: in vivo metabolic changes in the frontal and parietal cortices in 6-OHDA treated rats during different periods.
Topics: Animals; Aspartic Acid; Choline; Corpus Striatum; Creatine; Disease Models, Animal; Frontal Lobe; Functional Laterality; Functional Neuroimaging; Glutamates; Glutamic Acid; Glutamine; Magnetic Resonance Spectroscopy; Male; Motor Activity; Oxidopamine; Parietal Lobe; Parkinson Disease, Secondary; Rats; Substantia Nigra; Time Factors | 2014 |
On the use of Cramér-Rao minimum variance bounds for the design of magnetic resonance spectroscopy experiments.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Monte Carlo Method | 2013 |
Impairment of neuronal glutamate uptake and modulation of the glutamate transporter GLT-1 induced by retinal ischemia.
Topics: Animals; Aspartic Acid; Biological Transport; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glutamic Acid; Intraocular Pressure; Ischemia; Male; Neurons; Rats; Rats, Wistar; Retina; Synaptosomes | 2013 |
Single glutamate to aspartate mutation makes ferric uptake regulator (Fur) as sensitive to H2O2 as peroxide resistance regulator (PerR).
Topics: Amino Acid Sequence; Aspartic Acid; Bacteria; Bacterial Proteins; Glutamic Acid; Humans; Hydrogen Peroxide; Models, Molecular; Molecular Sequence Data; Point Mutation; Repressor Proteins; Sequence Alignment; Spectroscopy, Mossbauer | 2013 |
Effects of Zn2+ binding on the structural and dynamic properties of amyloid β peptide associated with Alzheimer's disease: Asp1 or Glu11?
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Glutamic Acid; Humans; Markov Chains; Models, Genetic; Molecular Dynamics Simulation; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Proteostasis Deficiencies; Structure-Activity Relationship; Zinc | 2013 |
Selective fluorescent detection of aspartic acid and glutamic acid employing dansyl hydrazine dextran conjugate.
Topics: Aspartic Acid; Dansyl Compounds; Dextrans; Fluorescence; Glutamic Acid; Hydrazines; Molecular Structure; Spectrometry, Fluorescence | 2014 |
Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy.
Topics: Aspartic Acid; Biomarkers; Bipolar Disorder; Case-Control Studies; Female; Functional Neuroimaging; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Humans; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Pilot Projects; Prefrontal Cortex; Young Adult | 2014 |
Site-specific characterization of the Asp- and Glu-ADP-ribosylated proteome.
Topics: Adenosine Diphosphate Ribose; Aspartic Acid; Binding Sites; DNA Damage; Gene Knockdown Techniques; Glutamic Acid; Glycoside Hydrolases; HCT116 Cells; Humans; Hydrogen Peroxide; Models, Molecular; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Conformation; Protein Processing, Post-Translational; Proteome | 2013 |
Motor system alterations in retired former athletes: the role of aging and concussion history.
Topics: Age Factors; Aged; Aging; Analysis of Variance; Apolipoproteins E; Aspartic Acid; Brain; Brain Concussion; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Motor Activity; Motor Cortex; Neuropsychological Tests; Photic Stimulation; Protons; Reaction Time; Regression Analysis; Surveys and Questionnaires | 2013 |
(1)H-MRS of hippocampus in patients after first manic episode.
Topics: Adolescent; Adult; Aspartic Acid; Bipolar Disorder; Choline; Creatine; Glutamic Acid; Glutamine; Hippocampus; Humans; Hydrogen; Inositol; Magnetic Resonance Spectroscopy; Male; Neurons; Prospective Studies; Time Factors; Young Adult | 2014 |
Significant strength of charged DNA-protein π-π interactions: a preliminary study of cytosine.
Topics: Arginine; Aspartic Acid; Cytosine; Dimerization; DNA; Glutamic Acid; Models, Molecular; Protein Binding; Proteins; Quantum Theory; Thermodynamics | 2013 |
Reduced frontal glutamate + glutamine and N-acetylaspartate levels in patients with chronic schizophrenia but not in those at clinical high risk for psychosis or with first-episode schizophrenia.
Topics: Adolescent; Adult; Aspartic Acid; Chronic Disease; Disease Progression; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Prodromal Symptoms; Psychotic Disorders; Risk; Schizophrenia; Young Adult | 2014 |
A follow-up study of neurometabolic alterations in female concussed athletes.
Topics: Aspartic Acid; Athletes; Athletic Injuries; Brain Chemistry; Brain Concussion; Creatine; Depression; Female; Follow-Up Studies; Glutamic Acid; Glutamine; Hippocampus; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Prefrontal Cortex; Young Adult | 2014 |
Age-related changes in a patient with Pelizaeus-Merzbacher disease determined by repeated 1H-magnetic resonance spectroscopy.
Topics: Aging; Aspartic Acid; Case-Control Studies; Child, Preschool; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Infant; Inositol; Magnetic Resonance Spectroscopy; Male; Parietal Lobe; Pelizaeus-Merzbacher Disease | 2014 |
Increased extracellular glutamate in the nucleus accumbens promotes excessive ethanol drinking in ethanol dependent mice.
Topics: Alcohol Drinking; Alcoholism; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Excitatory Amino Acid Agents; Extracellular Fluid; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Microdialysis; Microinjections; Nucleus Accumbens | 2014 |
Functional convergence of structurally distinct thioesterases from cyanobacteria and plants involved in phylloquinone biosynthesis.
Topics: Arabidopsis; Aspartic Acid; Catalytic Domain; Crystallography, X-Ray; Glutamic Acid; Hydro-Lyases; Naphthols; Naphthoquinones; Protein Binding; Protein Folding; Protein Multimerization; Synechocystis; Thiolester Hydrolases; Vitamin K 1 | 2013 |
Increased hippocampal glutamate and volumetric deficits in unmedicated patients with schizophrenia.
Topics: Adult; Aspartic Acid; Biomarkers; Creatine; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Hydrogen; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multimodal Imaging; Schizophrenia; Young Adult | 2013 |
Effects of fat on MR-measured metabolite signal strengths: implications for in vivo MRS studies of the human brain.
Topics: Adiposity; Adult; Animals; Aspartic Acid; Brain; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Metabolome; Occipital Lobe; Phantoms, Imaging; Phosphocreatine; Signal Processing, Computer-Assisted; Software; Sus scrofa | 2013 |
Glutamate dysregulation in the trigeminal ganglion: a novel mechanism for peripheral sensitization of the craniofacial region.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anesthetics, Local; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Lidocaine; Male; Mice; Muscle, Skeletal; Neural Conduction; Neurons; Potassium Chloride; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Time Factors; Trigeminal Ganglion | 2014 |
1H NMR metabolomic signatures in five brain regions of the AβPPswe Tg2576 mouse model of Alzheimer's disease at four ages.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Biomarkers; Cerebellum; Cerebral Cortex; Disease Models, Animal; Genotype; Glutamic Acid; Hippocampus; Magnetic Resonance Spectroscopy; Male; Mesencephalon; Metabolome; Mice; Mice, Transgenic; Tissue Extracts | 2014 |
SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct.
Topics: Animals; Aspartic Acid; Catalysis; Epithelial Cells; Gene Expression Regulation; Glutamic Acid; HEK293 Cells; Humans; Kidney Tubules, Collecting; Organic Anion Transporters; Protein Transport; Rats | 2014 |
Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.
Topics: Animals; Aspartic Acid; Botulinum Toxins; Botulinum Toxins, Type A; Catalytic Domain; Cell Membrane; Cells, Cultured; Cytosol; Glutamic Acid; Hydrogen-Ion Concentration; Mice; Mutation; Neurons; Neurotoxins; Protein Transport; Protons | 2013 |
Ammonia mediates methamphetamine-induced increases in glutamate and excitotoxicity.
Topics: Ammonia; Animals; Aspartic Acid; Body Temperature; Brain; Calpain; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Administration Routes; Glial Fibrillary Acidic Protein; Glutamic Acid; Lactulose; Male; Methamphetamine; Molecular Weight; Rats; Rats, Sprague-Dawley; Spectrin; Time Factors | 2014 |
Effect of oxindolimine copper(II) and zinc(II) complexes on human topoisomerase I activity.
Topics: Aspartic Acid; Binding Sites; Biocatalysis; Bridged Bicyclo Compounds; Circular Dichroism; Coordination Complexes; Copper; DNA Topoisomerases, Type I; DNA, Circular; Glutamic Acid; Humans; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Oligonucleotides; Protein Binding; Protein Structure, Tertiary; Topoisomerase I Inhibitors; Zinc | 2014 |
Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina.
Topics: Animals; Aspartic Acid; Biological Transport; Brain; Citric Acid Cycle; Glutamic Acid; Metabolomics; Mice; Mitochondria; Neurons; Oxygen; Purinones; Pyruvic Acid; Retina | 2013 |
Reversal of metabolic deficits by lipoic acid in a triple transgenic mouse model of Alzheimer's disease: a 13C NMR study.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Citric Acid Cycle; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Mice; Mice, Transgenic; Thioctic Acid; Vitamin B Complex | 2014 |
Preliminary differences in peripheral immune markers and brain metabolites between fatigued and non-fatigued breast cancer survivors: a pilot study.
Topics: Aspartic Acid; Biomarkers; Brain; Breast Neoplasms; Creatine; Cross-Sectional Studies; Fatigue; Female; Glutamic Acid; Glutamine; Humans; Interleukin-6; Middle Aged; Phosphocreatine; Pilot Projects; Prognosis; Proton Magnetic Resonance Spectroscopy; Sensitivity and Specificity; Severity of Illness Index; Survivors | 2014 |
Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Calcium; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycogen; Hydrogen-Ion Concentration; Hypoglycemia; Kynurenic Acid; Lactic Acid; Leukoencephalopathies; Mice; Mice, Inbred C57BL; Optic Nerve Injuries; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 2014 |
An acute glutamate exposure induces long-term down regulation of GLAST/EAAT1 uptake activity in cultured Bergmann glia cells.
Topics: Animals; Aspartic Acid; Cell Membrane; Cells, Cultured; Cerebellum; Chick Embryo; Down-Regulation; Excitatory Amino Acid Transporter 1; Glutamic Acid; Neuroglia | 2014 |
Intrathecal ultra-low dose naloxone enhances the antihyperalgesic effects of morphine and attenuates tumor necrosis factor-α and tumor necrosis factor-α receptor 1 expression in the dorsal horn of rats with partial sciatic nerve transection.
Topics: Analgesics, Opioid; Animals; Aspartic Acid; Behavior, Animal; Disease Models, Animal; Down-Regulation; Drug Synergism; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Morphine; Naloxone; Narcotic Antagonists; Pain Threshold; Posterior Horn Cells; Rats; Rats, Wistar; Reaction Time; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Sciatic Nerve; Sciatica; Time Factors; Tumor Necrosis Factor-alpha | 2013 |
Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Aspartic Acid; Astrocytes; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunoprecipitation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ouabain; Phenethylamines; Pyrimidines; Receptor, Adenosine A2A; Sodium-Potassium-Exchanging ATPase; Subcellular Fractions; Triazoles; Tritium | 2013 |
Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users.
Topics: Adult; Aspartic Acid; Brain; Female; Glutamic Acid; Glutamine; Humans; Ketamine; Magnetic Resonance Spectroscopy; Male; Psychotic Disorders; Substance-Related Disorders; Young Adult | 2014 |
Inhibitory effects of beta-amyloid on the nicotinic receptors which stimulate glutamate release in rat hippocampus: the glial contribution.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Aspartic Acid; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Choline; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peptide Fragments; Pyridines; Quinuclidines; Rats; Rats, Wistar; Receptors, Nicotinic | 2014 |
Effects of cochlear ablation on amino acid levels in the rat cochlear nucleus and superior olive.
Topics: Ablation Techniques; Amino Acids; Animals; Aspartic Acid; Auditory Pathways; Chromatography, High Pressure Liquid; Cochlea; Cochlear Nucleus; Glutamic Acid; Microdissection; Olivary Nucleus; Rats; Taurine; Time Factors | 2014 |
Niflumic acid activates additional currents of the human glial L-glutamate transporter EAAT1 in a substrate-dependent manner.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Excitatory Amino Acid Transporter 1; Glutamic Acid; Humans; In Vitro Techniques; Niflumic Acid; Oocytes; Sodium; Xenopus laevis | 2013 |
Deciphering the role of aspartate and prephenate aminotransferase activities in plastid nitrogen metabolism.
Topics: Asparagine; Aspartate Aminotransferases; Aspartic Acid; Chlorophyll; Gene Expression Regulation, Plant; Gene Silencing; Glutamic Acid; Lignin; Multigene Family; Nicotiana; Nitrogen; Phenylalanine; Plant Leaves; Plant Proteins; Plastids; Transaminases | 2014 |
Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adult; Asian People; Aspartic Acid; Female; Genetic Predisposition to Disease; Germ-Line Mutation; Glutamic Acid; Glycine; Humans; Japan; Lung Neoplasms; Male; Middle Aged; Pedigree; Receptor, ErbB-2; Valine | 2014 |
Antiepileptic potential of matrine via regulation the levels of gamma-aminobutyric acid and glutamic acid in the brain.
Topics: Alkaloids; Animals; Anticonvulsants; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Glycine; Male; Matrines; Mice; Mice, Inbred ICR; Motor Activity; Pentylenetetrazole; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Seizures; Up-Regulation | 2013 |
NMR-monitored titration of acid-stress bacterial chaperone HdeA reveals that Asp and Glu charge neutralization produces a loosened dimer structure in preparation for protein unfolding and chaperone activation.
Topics: Aspartic Acid; Dimerization; Dysentery; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Molecular Chaperones; Protein Binding; Protein Conformation; Protein Unfolding | 2014 |
Chronic and acute alcohol administration induced neurochemical changes in the brain: comparison of distinct zebrafish populations.
Topics: Animals; Aspartic Acid; Brain; Dopamine; Ethanol; Female; Glutamic Acid; Male; Serotonin; Zebrafish | 2014 |
Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance.
Topics: Amino Acid Sequence; Antibiotics, Antitubercular; Asparagine; Aspartic Acid; DNA-Directed RNA Polymerases; Drug Resistance, Bacterial; Glutamic Acid; Glutamine; Molecular Sequence Data; Mutation; Mycobacterium smegmatis; Phenotype; Protein Biosynthesis; Proteomics; Recombination, Genetic; Rifampin | 2014 |
Myoinositol and glutamate complex neurometabolite abnormality after mild traumatic brain injury.
Topics: Adult; Aspartic Acid; Brain Injuries; Case-Control Studies; Caudate Nucleus; Choline; Corpus Striatum; Creatine; Female; Globus Pallidus; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Fibers, Unmyelinated; Putamen; Thalamus; Young Adult | 2014 |
Assessment of changes in brain metabolites in Indian patients with type-2 diabetes mellitus using proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Brain Chemistry; Choline; Creatinine; Diabetes Mellitus, Type 2; Glucose; Glutamic Acid; Glutamine; Humans; India; Inositol; Magnetic Resonance Spectroscopy; Pilot Projects; Prospective Studies; Protons; Tertiary Care Centers | 2014 |
Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.
Topics: Aging; Animals; Aspartic Acid; Corpus Striatum; Glutamate Dehydrogenase; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Receptors, Glutamate; Synapses | 2014 |
Neurochemical correlates of caudate atrophy in Huntington's disease.
Topics: Adult; Aged; Aspartic Acid; Atrophy; Caudate Nucleus; Female; Glutamic Acid; Humans; Huntington Disease; Magnetic Resonance Imaging; Male; Middle Aged; Motor Activity; Mutation; Young Adult | 2014 |
Metabolic maturation of white matter is altered in preterm infants.
Topics: Age Factors; Aspartic Acid; Body Water; Brain; Choline; Creatine; Glutamic Acid; Humans; Infant, Newborn; Infant, Premature; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Radiography; Time Factors; Water | 2014 |
Three amino acid derivatives of valproic acid: design, synthesis, theoretical and experimental evaluation as anticancer agents.
Topics: Antineoplastic Agents; Aspartic Acid; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Glutamic Acid; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Molecular Docking Simulation; Molecular Dynamics Simulation; Proline; Repressor Proteins; Structure-Activity Relationship; Valproic Acid | 2014 |
Association of bi-functional activity in the N-terminal domain of glycogen debranching enzyme.
Topics: Aspartic Acid; Binding Sites; Cyclodextrins; Electrophoresis, Polyacrylamide Gel; Glucose; Glucosidases; Glutamic Acid; Glycogen Debranching Enzyme System; Glycosyltransferases; Maltose; Mutation; Saccharomyces cerevisiae Proteins; Substrate Specificity | 2014 |
The 4-pyridylmethyl ester as a protecting group for glutamic and aspartic acids: 'flipping' peptide charge states for characterization by positive ion mode ESI-MS.
Topics: Aspartic Acid; Glutamic Acid; Peptides; Spectrometry, Mass, Electrospray Ionization | 2014 |
Metal cation dependence of interactions with amino acids: bond dissociation energies of Rb(+) and Cs(+) to the acidic amino acids and their amide derivatives.
Topics: Asparagine; Aspartic Acid; Cations; Cesium; Computer Simulation; Entropy; Glutamic Acid; Glutamine; Kinetics; Models, Chemical; Potassium; Quantum Theory; Rubidium; Sodium; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Xenon | 2014 |
Arginyltransferase ATE1 catalyzes midchain arginylation of proteins at side chain carboxylates in vivo.
Topics: Aminoacyltransferases; Angiotensin II; Animals; Aspartic Acid; Biocatalysis; Chromatography, High Pressure Liquid; Glutamic Acid; Humans; Mice; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity | 2014 |
1H-proton magnetic resonance spectroscopy differentiates dementia with Lewy bodies from Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspartic Acid; Cerebral Cortex; Chi-Square Distribution; Female; Glutamic Acid; Humans; Lewy Body Disease; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; ROC Curve | 2014 |
High-field proton magnetic resonance spectroscopy reveals metabolic effects of normal brain aging.
Topics: Aging; Animals; Aspartic Acid; Brain; Choline; Functional Neuroimaging; Glucose; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Neurochemistry; Protons; Rats; Rats, Inbred F344 | 2014 |
A "SYDE" effect of hierarchical phosphorylation: possible relevance to the cystic fibrosis basic defect.
Topics: Amino Acid Sequence; Aspartic Acid; Casein Kinase II; Consensus Sequence; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dictyostelium; Glutamic Acid; Humans; Molecular Sequence Data; Phosphorylation; Protein Interaction Domains and Motifs; Serine; Tyrosine | 2014 |
Effects of catalpol on ATPase and amino acids in gerbils with cerebral ischemia/reperfusion injury.
Topics: Adenosine Triphosphatases; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Carotid Artery, Common; Cell Membrane; Constriction; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Gerbillinae; Glutamic Acid; Iridoid Glucosides; Male; Models, Animal; Molecular Structure; Nerve Tissue Proteins; Neuroprotective Agents; Premedication; Reperfusion Injury; Single-Blind Method | 2014 |
Casein mediated green synthesis and decoration of reduced graphene oxide.
Topics: Animals; Aspartic Acid; Caseins; Glutamic Acid; Graphite; Green Chemistry Technology; Milk; Nanostructures; Oxidation-Reduction; Oxides | 2014 |
Influence of parafascicular thalamic input on neuronal activity within the nucleus accumbens is mediated by nitric oxide - an in vivo study.
Topics: Animals; Aspartic Acid; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Hydrazines; Intralaminar Thalamic Nuclei; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2014 |
Glutamate and choline levels predict individual differences in reading ability in emergent readers.
Topics: Aspartic Acid; Brain; Child; Choline; Dyslexia; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Individuality; Learning; Magnetic Resonance Spectroscopy; Male; Phonetics; Predictive Value of Tests; Reading; Vocabulary | 2014 |
High extracellular concentration of excitatory amino acids glutamate and aspartate in human brain abscess.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Abscess; Child; Child, Preschool; Extracellular Space; Female; Glutamic Acid; Humans; Male; Middle Aged; Seizures; Young Adult | 2014 |
Spectroscopic investigation of interaction between bovine serum albumin and amine-functionalized silicon quantum dots.
Topics: Amines; Animals; Aspartic Acid; Cattle; Circular Dichroism; Glutamic Acid; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Kinetics; Protein Binding; Protein Structure, Secondary; Quantum Dots; Serum Albumin, Bovine; Silicon; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Static Electricity; Temperature; Thermodynamics | 2014 |
Large conductance calcium-activated potassium channels: their expression and modulation of glutamate release from nerve terminals isolated from rat trigeminal caudal nucleus and cerebral cortex.
Topics: Animals; Aspartic Acid; Benzimidazoles; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamic Acid; Indoles; Large-Conductance Calcium-Activated Potassium Channels; Male; Peptides; Protein Subunits; Rats, Wistar; Synaptosomes; Trigeminal Caudal Nucleus | 2014 |
L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain.
Topics: Animals; Aspartic Acid; Crystallography, X-Ray; Glutamic Acid; Ligands; Models, Molecular; Protein Binding; Protein Stability; Protein Structure, Tertiary; Rats; Receptors, AMPA; Recombinant Proteins | 2014 |
Reproducibility and reliability of short-TE whole-brain MR spectroscopic imaging of human brain at 3T.
Topics: Adult; Algorithms; Aspartic Acid; Brain; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Male; Models, Biological; Molecular Imaging; Proton Magnetic Resonance Spectroscopy; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution | 2015 |
Prefrontal grey and white matter neurometabolite changes after atomoxetine and methylphenidate in children with attention deficit/hyperactivity disorder: a (1)H magnetic resonance spectroscopy study.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Aspartic Acid; Atomoxetine Hydrochloride; Attention; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Methylphenidate; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Prefrontal Cortex; Propylamines; Treatment Outcome | 2014 |
Accuracy of 2-hydroxyglutarate quantification by short-echo proton-MRS at 3 T: a phantom study.
Topics: Aspartic Acid; Brain; Glioma; Glutamic Acid; Glutarates; Humans; Isocitrate Dehydrogenase; Mutation; Phantoms, Imaging; Proton Magnetic Resonance Spectroscopy | 2014 |
Cysteine mutagenesis reveals alternate proximity between transmembrane domain 2 and hairpin loop 1 of the glutamate transporter EAAT1.
Topics: Amino Acid Sequence; Aspartic Acid; Cadmium Chloride; Cross-Linking Reagents; Cysteine; Dithiothreitol; Excitatory Amino Acid Transporter 1; Glutamic Acid; HeLa Cells; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenanthrolines; Protein Structure, Tertiary; Structure-Activity Relationship | 2014 |
Reduction in glutamine/glutamate levels in the cerebral cortex after adrenocorticotropic hormone therapy in patients with west syndrome.
Topics: Adrenocorticotropic Hormone; Aspartic Acid; Choline; Cosyntropin; Electroencephalography; Female; Glutamic Acid; Glutamine; Humans; Infant; Inositol; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Spasms, Infantile | 2014 |
Cellular senescence induced by prolonged subculture adversely affects glutamate uptake in C6 lineage.
Topics: Animals; Aspartic Acid; Cellular Senescence; Glioma; Glutamic Acid; Rats, Wistar; Tritium; Tumor Cells, Cultured | 2014 |
Multidrug transport protein norM from vibrio cholerae simultaneously couples to sodium- and proton-motive force.
Topics: Antiporters; Aspartic Acid; Bacterial Proteins; Binding Sites; Biological Transport; Blotting, Western; Cell Membrane; DNA; Ethidium; Glutamic Acid; Lactococcus lactis; Models, Molecular; Mutation; Protein Binding; Protein Structure, Tertiary; Proteolipids; Proton-Motive Force; Protons; Sodium; Vibrio cholerae | 2014 |
Differential effects of prenatal chronic high-decibel noise and music exposure on the excitatory and inhibitory synaptic components of the auditory cortex analog in developing chicks (Gallus gallus domesticus).
Topics: Acoustic Stimulation; Animals; Aspartic Acid; Auditory Cortex; Avian Proteins; Carrier Proteins; Chick Embryo; Chickens; gamma-Aminobutyric Acid; Glutamic Acid; Membrane Proteins; Music; Neurons; Noise; Periodicity; Pressure; Prosencephalon; Synapses; Synaptophysin | 2014 |
Synaptic glutamate spillover due to impaired glutamate uptake mediates heroin relapse.
Topics: Animals; Aspartic Acid; Ceftriaxone; Conditioning, Operant; Disease Models, Animal; Down-Regulation; Drug-Seeking Behavior; Excitatory Postsynaptic Potentials; Glutamic Acid; Heroin; Heroin Dependence; In Vitro Techniques; Male; Morpholinos; Neurons; Nucleus Accumbens; Potassium; Rats; Rats, Sprague-Dawley; Secondary Prevention; Synapses | 2014 |
Effect of side chain length on intrahelical interactions between carboxylate- and guanidinium-containing amino acids.
Topics: 2-Aminoadipic Acid; Alanine; Amino Acid Sequence; Amino Acids; Arginine; Aspartic Acid; Carboxylic Acids; Circular Dichroism; Glutamic Acid; Guanidine; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Conformation; Peptides; Protein Structure, Secondary; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Static Electricity; Thermodynamics | 2014 |
Feeling safe in the plane: neural mechanisms underlying superior action control in airplane pilot trainees--a combined EEG/MRS study.
Topics: Acoustic Stimulation; Adult; Aircraft; Aspartic Acid; Brain; Brain Mapping; Brain Waves; Electroencephalography; Emotions; Evoked Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Photic Stimulation; Safety; Teaching; User-Computer Interface; Young Adult | 2014 |
Neurobehaviour between birth and 40 weeks' gestation in infants born <30 weeks' gestation and parental psychological wellbeing: predictors of brain development and child outcomes.
Topics: Aspartic Acid; Biomarkers; Brain; Case-Control Studies; Child Development; Choline; Gestational Age; Glutamic Acid; Glutamine; Humans; Infant, Newborn; Infant, Premature; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mental Health; Neurologic Examination; Neuropsychological Tests; Parent-Child Relations; Parenting; Parents; Premature Birth; Prospective Studies; Term Birth | 2014 |
[1H NMR based metabonomics study on the antidepressant effect of genipin in rat hippocampus].
Topics: Alanine; Animals; Antidepressive Agents; Aspartic Acid; Behavior, Animal; Chronic Disease; Depression; Gardenia; Glutamic Acid; Glycine; Hippocampus; Inositol; Iridoids; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Metabolomics; Plants, Medicinal; Rats; Rats, Sprague-Dawley | 2014 |
Decreased plasma neuroactive amino acids and increased nitric oxide levels in melancholic major depressive disorder.
Topics: Adult; Aged; Amino Acids; Antidepressive Agents; Aspartic Acid; Biomarkers; Depressive Disorder, Major; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Male; Middle Aged; Nitric Oxide; Young Adult | 2014 |
New force field parameters for metalloproteins I: Divalent copper ion centers including three histidine residues and an oxygen-ligated amino acid residue.
Topics: Aspartic Acid; Copper; Glutamic Acid; Histidine; Metalloproteins; Models, Molecular; Molecular Dynamics Simulation; Thermodynamics; Tyrosine | 2014 |
Low resolution X-ray structure of γ-glutamyltranspeptidase from Bacillus licheniformis: opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion.
Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Bacillus; Bacillus subtilis; Bacterial Proteins; Catalytic Domain; Cations, Divalent; Crystallography, X-Ray; Escherichia coli; gamma-Glutamyltransferase; Glutamic Acid; Humans; Kinetics; Magnesium; Mutagenesis, Site-Directed; Protein Stability; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Recombinant Proteins | 2014 |
[NMR-based analysis of water soluble extracts of different Astragali Radix].
Topics: Arginine; Aspartic Acid; Astragalus propinquus; Choline; Citric Acid; Drugs, Chinese Herbal; Fumarates; Glutamic Acid; Magnetic Resonance Spectroscopy; Multivariate Analysis; Phylogeography; Plant Roots; Plants, Medicinal; Succinic Acid; Sucrose; Taurine | 2014 |
Effect of Gua Lou Gui Zhi decoction on focal cerebral ischemia-reperfusion injury through regulating the expression of excitatory amino acids and their receptors.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Excitatory Amino Acids; Glutamic Acid; Glycine; Immunohistochemistry; Male; Motor Activity; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2014 |
Competitive formation of b(2) and c(2)-H2O ions from b(3) ions containing Asp residue during tandem mass spectrometry: the influence of neighboring Arg.
Topics: Arginine; Aspartic Acid; Glutamic Acid; Guanidine; Ions; Phenylalanine; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Water | 2014 |
Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality.
Topics: Arousal; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Humans; Male; Proton Magnetic Resonance Spectroscopy; Self Report; Sleep; Sleep Initiation and Maintenance Disorders; Stress Disorders, Post-Traumatic; United States | 2014 |
Motor axon synapses on renshaw cells contain higher levels of aspartate than glutamate.
Topics: Analysis of Variance; Animals; Aspartic Acid; Axons; Calbindins; Glutamic Acid; Image Processing, Computer-Assisted; Immunohistochemistry; Mice; Mice, Inbred C57BL; Microscopy, Immunoelectron; Motor Neurons; Renshaw Cells; Synapses; Vesicular Acetylcholine Transport Proteins | 2014 |
Effect of diet on brain metabolites and behavior in spontaneously hypertensive rats.
Topics: Animals; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Brain; Creatine; Dietary Fats; Disease Models, Animal; Energy Metabolism; Fish Oils; Frontal Lobe; Glutamic Acid; Locomotion; Male; Maze Learning; Motor Activity; Proton Magnetic Resonance Spectroscopy; Psychomotor Performance; Rats; Rats, Inbred SHR; Risk-Taking | 2014 |
Retinal chromophore structure and Schiff base interactions in red-shifted channelrhodopsin-1 from Chlamydomonas augustae.
Topics: Anions; Aspartic Acid; Chlamydomonas; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Rhodopsin; Rhodopsins, Microbial; Schiff Bases; Sensory Rhodopsins; Spectrum Analysis, Raman | 2014 |
In silico concurrent multisite pH titration in proteins.
Topics: Animals; Aspartic Acid; Cattle; Glutamic Acid; Hydrogen-Ion Concentration; Models, Molecular; Molecular Dynamics Simulation; Pancreas; Protein Conformation; Protons; Thermodynamics; Trypsin Inhibitor, Kazal Pancreatic | 2014 |
Role of Na,K-ATPase α1 and α2 isoforms in the support of astrocyte glutamate uptake.
Topics: Animals; Aspartic Acid; Astrocytes; Biological Transport; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Gene Expression; Glutamic Acid; Intracellular Space; Isoenzymes; Protein Binding; Rats; Sodium; Sodium-Potassium-Exchanging ATPase | 2014 |
Prefrontal glutamate levels differentiate early phase schizophrenia and methamphetamine addiction: a (1)H MRS study at 3Tesla.
Topics: Adolescent; Adult; Amphetamine-Related Disorders; Aspartic Acid; Glutamic Acid; Humans; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Young Adult | 2014 |
Control of catalytic efficiency by a coevolving network of catalytic and noncatalytic residues.
Topics: Aspartic Acid; Binding Sites; Biocatalysis; Catalytic Domain; Endonucleases; Evolution, Molecular; Glutamic Acid; Models, Genetic; Models, Molecular; Mutation; Phylogeny; Protein Structure, Tertiary | 2014 |
Magnetic resonance spectroscopy and tissue protein concentrations together suggest lower glutamate signaling in dentate gyrus in schizophrenia.
Topics: Adolescent; Adult; Animals; Aspartic Acid; Dentate Gyrus; Disease Models, Animal; Gene Expression Regulation; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Knockout; Middle Aged; Nerve Tissue Proteins; Postmortem Changes; Protons; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction; Young Adult | 2015 |
Specialized postsynaptic morphology enhances neurotransmitter dilution and high-frequency signaling at an auditory synapse.
Topics: Algorithms; Animals; Aspartic Acid; Benzothiadiazines; Calcium; Computer Simulation; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hair Cells, Auditory; Male; Microscopy, Electron; Models, Neurological; Neurotransmitter Agents; Patch-Clamp Techniques; Rana catesbeiana; Signal Transduction; Synaptic Transmission | 2014 |
Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147.
Topics: Adult; Aged; Aspartic Acid; Clinical Trials, Phase III as Topic; Colonic Neoplasms; DNA Mismatch Repair; Female; Glutamic Acid; Glycine; Humans; Logistic Models; Male; Middle Aged; Molecular Epidemiology; Mutation; Neoplasm Grading; Prospective Studies; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); ras Proteins; Surveys and Questionnaires; Valine | 2014 |
Fish oil omega-3 fatty acids reduce the severity of radiation-induced oxidative stress in the rat brain.
Topics: Animals; Aspartic Acid; Brain; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Gamma Rays; Glutamic Acid; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Serotonin | 2014 |
The C-glycosyltransferase IroB from pathogenic Escherichia coli: identification of residues required for efficient catalysis.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Biocatalysis; Catalytic Domain; Enterobactin; Escherichia coli Proteins; Glucosyltransferases; Glutamic Acid; Glycosylation; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Sequence Alignment; Siderophores; Structural Homology, Protein; Tryptophan; Uridine Diphosphate Glucose; Uropathogenic Escherichia coli | 2014 |
GABA, resting-state connectivity and the developing brain.
Topics: Age Factors; Aspartic Acid; Brain; Case-Control Studies; Child Development; Choline; Female; gamma-Aminobutyric Acid; Gestational Age; Glutamic Acid; Humans; Infant; Infant, Premature; Interneurons; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neural Pathways; Pilot Projects; Signal Transduction | 2014 |
Examining the amine functionalization in dicarboxylates: photoelectron spectroscopy and theoretical studies of aspartate and glutamate.
Topics: Aspartic Acid; Computer Simulation; Dicarboxylic Acids; Electrons; Glutamic Acid; Hydrogen Bonding; Models, Chemical; Photoelectron Spectroscopy; Propionates; Succinic Acid | 2014 |
Higher glutamate+glutamine and reduction of N-acetylaspartate in posterior cingulate according to age range in patients with cognitive impairment and/or pain.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aspartic Acid; Case-Control Studies; Cognition Disorders; Creatine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pain; Prospective Studies | 2014 |
Preliminary X-ray crystallographic analysis of an engineered glutamyl-tRNA synthetase from Escherichia coli.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Crystallography, X-Ray; Escherichia coli; Gene Expression; Glutamate-tRNA Ligase; Glutamic Acid; Kinetics; Lysine; Models, Molecular; Molecular Sequence Data; Mutation; Protein Engineering; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Sequence Alignment; Structural Homology, Protein; Substrate Specificity | 2014 |
Transmitter self-regulation by extracellular glutamate in fresh human cortical slices.
Topics: Adult; Aged; Aspartic Acid; Cerebral Cortex; Chromatography, High Pressure Liquid; Extracellular Fluid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; In Vitro Techniques; Male; Methionine; Middle Aged; Neurons; Tetrodotoxin; Time Factors; Veratridine | 2014 |
In vivo evidence of glutamate toxicity in multiple sclerosis.
Topics: Adult; Aspartic Acid; Brain; Female; Follow-Up Studies; Glutamic Acid; History, Ancient; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Multiple Sclerosis | 2014 |
Brain infection with Staphylococcus aureus leads to high extracellular levels of glutamate, aspartate, γ-aminobutyric acid, and zinc.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain Abscess; Caspase 3; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Extracellular Fluid; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamic Acid; Male; Microdialysis; Phosphopyruvate Hydratase; Rats; Rats, Wistar; Staphylococcal Infections; Staphylococcus aureus; Synaptophysin; Zinc | 2014 |
Sensitivity encoding for fast (1) H MR spectroscopic imaging water reference acquisition.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Brain Mapping; Choline; Creatine; Glutamic Acid; Healthy Volunteers; Humans; Image Enhancement; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Phantoms, Imaging; Reproducibility of Results; Water | 2015 |
Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance hypothesis.
Topics: Adult; Aspartic Acid; Brain Mapping; Cerebellum; Child Development Disorders, Pervasive; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Psychometrics | 2014 |
Exposure to high glutamate concentration activates aerobic glycolysis but inhibits ATP-linked respiration in cultured cortical astrocytes.
Topics: Adenosine Triphosphate; Aerobiosis; Animals; Aspartic Acid; Astrocytes; Cell Respiration; Cerebral Cortex; Energy Metabolism; Glutamic Acid; Glycolysis; Mitochondria; Oxygen Consumption; Primary Cell Culture; Rats, Sprague-Dawley; Vitamin E | 2014 |
The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids.
Topics: Actin Cytoskeleton; Amino Acid Sequence; Animals; Aspartic Acid; Carboxypeptidases; Catalytic Domain; Cell Line; Cilia; Glutamic Acid; Granzymes; HEK293 Cells; Humans; Mice; Mice, Knockout; Microtubules; Protein Processing, Post-Translational; Substrate Specificity | 2014 |
Polyelectrolyte multilayer-calcium phosphate composite coatings for metal implants.
Topics: Aspartic Acid; Calcium Phosphates; Coated Materials, Biocompatible; Crystallization; Glutamic Acid; Hydrogen-Ion Concentration; Lysine; Metals; Osmolar Concentration; Polymers; Prostheses and Implants; Surface Properties; Titanium | 2014 |
Ceftriaxone Protects Astrocytes from MPP(+) via Suppression of NF-κB/JNK/c-Jun Signaling.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Aspartic Acid; Astrocytes; Ceftriaxone; Cell Death; Cell Survival; Cells, Cultured; Glutamic Acid; Kinetics; MAP Kinase Signaling System; Neuroprotection; Neuroprotective Agents; NF-kappa B; Proto-Oncogene Proteins c-jun; Rats, Sprague-Dawley; Up-Regulation | 2015 |
Nitrogen limitation and high density responses in rice suggest a role for ethylene under high density stress.
Topics: Aspartic Acid; Ethylenes; Gene Expression Profiling; Genes, Plant; Glutamic Acid; Metabolomics; Nitrogen; Oryza; Stress, Physiological | 2014 |
Restless legs syndrome and central nervous system gamma-aminobutyric acid: preliminary associations with periodic limb movements in sleep and restless leg syndrome symptom severity.
Topics: Actigraphy; Adult; Aspartic Acid; Brain Chemistry; Case-Control Studies; Cerebellum; Female; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Humans; Male; Polysomnography; Proton Magnetic Resonance Spectroscopy; Restless Legs Syndrome; Severity of Illness Index; Thalamus | 2014 |
The aromatic and charge pairs of the thin extracellular gate of the γ-aminobutyric acid transporter GAT-1 are differently impacted by mutation.
Topics: Animals; Aspartic Acid; Biological Transport; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression; Glutamic Acid; HeLa Cells; Humans; Kinetics; Membrane Potentials; Models, Molecular; Mutation; Oocytes; Patch-Clamp Techniques; Phenylalanine; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Sodium; Structure-Activity Relationship; Xenopus laevis | 2014 |
Characterization of sulfonylurea-resistant Schoenoplectus juncoides having a target-site Asp(376)Glu mutation in the acetolactate synthase.
Topics: Acetolactate Synthase; Aspartic Acid; Benzoates; Cyperaceae; Glutamic Acid; Herbicide Resistance; Herbicides; Imidazoles; Mutation; Plant Proteins; Plant Weeds; Pyrimidines; Quinolines; Sulfur Compounds | 2013 |
Effect of ligustrazine on levels of amino acid neurotransmitters in rat striatum after cerebral ischemia-reperfusion injury.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Corpus Striatum; gamma-Aminobutyric Acid; Glutamic Acid; Infarction, Middle Cerebral Artery; Male; Microdialysis; Molecular Structure; Neurotransmitter Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Taurine; Time Factors | 2014 |
LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Glutamic Acid; Membrane Proteins; Osmotic Pressure; Rats; Rats, Sprague-Dawley; Taurine | 2014 |
Distribution of free amino acids, polyphenols and sugars of Ziziphus jujuba pulps harvested from plants grown in Tunisia.
Topics: Amino Acids; Aspartic Acid; Carbohydrates; Chromatography, Gas; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Galactose; Glucose; Glutamic Acid; Polyphenols; Proline; Sucrose; Tunisia; Ziziphus | 2015 |
Antifouling gold surfaces grafted with aspartic acid and glutamic acid based zwitterionic polymer brushes.
Topics: Acrylic Resins; Animals; Aspartic Acid; Cattle; Cell Adhesion; Cells, Cultured; Coated Materials, Biocompatible; Endothelial Cells; Glutamic Acid; Gold; Humans; Ultraviolet Rays | 2014 |
Investigating substrate-induced motion between the scaffold and transport domains in the glutamate transporter EAAT1.
Topics: Aspartic Acid; Cadmium; Cross-Linking Reagents; Excitatory Amino Acid Transporter 1; Glutamic Acid; HeLa Cells; Humans; Protein Structure, Tertiary | 2014 |
Substrate specificity of human protein arginine methyltransferase 7 (PRMT7): the importance of acidic residues in the double E loop.
Topics: Amino Acid Motifs; Amino Acid Sequence; Aspartic Acid; Biocatalysis; Catalytic Domain; Cations; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Glutamic Acid; Glutathione Transferase; Histones; Humans; Kinetics; Methylation; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein-Arginine N-Methyltransferases; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Substrate Specificity; Temperature | 2014 |
Evaluation of impact-induced traumatic brain injury in the Göttingen Minipig using two input modes.
Topics: Animals; Aspartic Acid; Brain Injuries; Dipeptides; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Swine; Swine, Miniature | 2014 |
Age related changes in metabolite concentrations in the normal spinal cord.
Topics: Adult; Age Factors; Aged; Aging; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Healthy Volunteers; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Reference Values; Spinal Cord; Young Adult | 2014 |
Effect of the replacement of aspartic acid/glutamic acid residues with asparagine/glutamine residues in RNase He1 from Hericium erinaceus on inhibition of human leukemia cell line proliferation.
Topics: Amino Acid Sequence; Amino Acid Substitution; Antineoplastic Agents; Asparagine; Aspartic Acid; Basidiomycota; Cell Proliferation; Glutamic Acid; Glutamine; HL-60 Cells; Humans; Hydrogen-Ion Concentration; Leukemia; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Ribonucleases; Structure-Activity Relationship | 2015 |
Phosphorylation of HPV-16 E2 at serine 243 enables binding to Brd4 and mitotic chromosomes.
Topics: Anaphase; Animals; Aspartic Acid; Cell Cycle Proteins; Chlorocebus aethiops; COS Cells; DNA-Binding Proteins; Genome, Viral; Glutamic Acid; Glutamine; HEK293 Cells; Human papillomavirus 16; Humans; Metaphase; Mutation; Nuclear Proteins; Oncogene Proteins, Viral; Phenotype; Phosphorylation; Protein Binding; Serine; Transcription Factors | 2014 |
Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity.
Topics: Animals; Aspartic Acid; Binding Sites; Calcium; Cations, Divalent; Cobalt; Glutamic Acid; HEK293 Cells; Humans; Male; Membrane Potentials; Mutation; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Rats, Inbred BN; Transfection; TRPM Cation Channels | 2014 |
GABA and glutamate in schizophrenia: a 7 T ¹H-MRS study.
Topics: Adult; Aspartic Acid; Brain Chemistry; Choline; Creatine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Intelligence; Male; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Schizophrenia; Young Adult | 2014 |
Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers.
Topics: Aspartic Acid; Calcium; Crystallography, X-Ray; Glutamic Acid; Humans; Mitochondria; Mitochondrial Membrane Transport Proteins; Protein Conformation; Protein Structure, Tertiary | 2014 |
A preliminary examination of cortical neurotransmitter levels associated with heavy drinking in posttraumatic stress disorder.
Topics: Adult; Aged; Alcoholism; Aspartic Acid; Cerebral Cortex; Choline; Comorbidity; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Male; Middle Aged; Pilot Projects; Proton Magnetic Resonance Spectroscopy; Stress Disorders, Post-Traumatic | 2014 |
Blockade of spinal glutamate recycling produces paradoxical antinociception in rats with orofacial inflammatory pain.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Botulinum Toxins, Type A; Facial Pain; Freund's Adjuvant; Glutamate-Ammonia Ligase; Glutamic Acid; Hyperalgesia; Injections, Intraventricular; Interleukin-1beta; Male; Methionine Sulfoximine; Nociception; Rats; Spinal Cord Dorsal Horn | 2015 |
Delayed circadian phase is linked to glutamatergic functions in young people with affective disorders: a proton magnetic resonance spectroscopy study.
Topics: Adolescent; Adult; Aspartic Acid; Female; Glutamic Acid; Glutathione; Gyrus Cinguli; Humans; Male; Mood Disorders; Proton Magnetic Resonance Spectroscopy; Sleep Disorders, Circadian Rhythm; Young Adult | 2014 |
1H-MRS of the anterior cingulate cortex in childhood and adolescent obsessive-compulsive disorder: a case-control study.
Topics: Adolescent; Aspartic Acid; Case-Control Studies; Child; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Male; Obsessive-Compulsive Disorder; Proton Magnetic Resonance Spectroscopy; Psychiatric Status Rating Scales | 2015 |
Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus.
Topics: Acute Disease; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Chronic Disease; Dibenzazepines; Disease Models, Animal; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Male; Mice; Seizures; Taurine; Thiazolidines | 2014 |
Amyloid-β1-42 Disrupts Synaptic Plasticity by Altering Glutamate Recycling at the Synapse.
Topics: Alanine Transaminase; Amyloid beta-Peptides; Analysis of Variance; Animals; Aspartic Acid; Biophysics; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred BALB C; Nerve Net; Neuronal Plasticity; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Pyruvic Acid; Synapses | 2015 |
A complex relative motion between hairpin loop 2 and transmembrane domain 5 in the glutamate transporter GLT-1.
Topics: Aspartic Acid; Dithiothreitol; Excitatory Amino Acid Transporter 2; Glutamic Acid; HeLa Cells; Humans; Kinetics; Mesylates; Protein Structure, Secondary; Protein Structure, Tertiary; Sodium Chloride; Sulfhydryl Compounds | 2015 |
Effects of a high-caloric diet and physical exercise on brain metabolite levels: a combined proton MRS and histologic study.
Topics: Animals; Aspartic Acid; Brain; Carbohydrate Metabolism; Diet; Dipeptides; Energy Intake; Fatty Acids; Glucose; Glutamic Acid; Hyperglycemia; Insulin; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Obesity; Physical Conditioning, Animal; Protons; Running | 2015 |
Carboxyl-peptide plane stacking is important for stabilization of buried E305 of Trichoderma reesei Cel5A.
Topics: Aspartic Acid; Cellulase; Glutamic Acid; Molecular Dynamics Simulation; Mutation; Protein Folding; Protein Stability; Quantum Theory; Trichoderma | 2015 |
Correlations of ADHD symptoms with neurometabolites measured by 1H magnetic resonance spectroscopy.
Topics: Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Child; Choline; Creatine; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Prefrontal Cortex; Radiography; White Matter | 2014 |
PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Astrocytes; Calcium; Citrates; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Male; Miniature Postsynaptic Potentials; Neurons, Afferent; Peptide Fragments; Rats; Rats, Long-Evans; Receptor, PAR-1; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Synapses; Vagus Nerve | 2015 |
Chronic social isolation decreases glutamate and glutamine levels and induces oxidative stress in the rat hippocampus.
Topics: Animals; Aspartic Acid; Catalase; Cerebral Cortex; Energy Metabolism; Female; Glutamic Acid; Glutamine; Glutathione Peroxidase; Hippocampus; Hydrogen Peroxide; Magnetic Resonance Spectroscopy; Male; Oxidative Stress; Phosphocreatine; Prefrontal Cortex; Pregnancy; Rats; Rats, Sprague-Dawley; Social Isolation; Superoxide Dismutase | 2015 |
Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-naïve and "depressed" mice exposed to chronic mild stress.
Topics: Animals; Antidepressive Agents; Aspartic Acid; Chronic Disease; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Glutamic Acid; Hippocampus; Ketamine; Male; Mice, Inbred C57BL; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Serotonin; Sex Characteristics; Stress, Psychological; Swimming; Time Factors | 2015 |
Glutamatergic and neurometabolic alterations in chronic cocaine users measured with (1) H-magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Cocaine-Related Disorders; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Imaging; Male; Middle Aged; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy | 2016 |
A tonoplast Glu/Asp/GABA exchanger that affects tomato fruit amino acid composition.
Topics: Amino Acids; Aspartic Acid; Biological Transport; Dipeptides; Fruit; gamma-Aminobutyric Acid; Genes, Reporter; Glutamic Acid; Intracellular Membranes; Nicotiana; Plant Proteins; Plants, Genetically Modified; Proteome; Solanum lycopersicum; Vacuoles | 2015 |
A comprehensive molecular dynamics approach to protein retention modeling in ion exchange chromatography.
Topics: Adsorption; Arginine; Aspartic Acid; Chromatography, Ion Exchange; Glutamic Acid; Lactalbumin; Light; Molecular Dynamics Simulation; Monte Carlo Method; Phospholipases A2; Proteins; Ribonuclease, Pancreatic; Scattering, Radiation; Sepharose | 2015 |
Amyloid-like hierarchical helical fibrils and conformational reversibility in functional polyesters based on L-amino acids.
Topics: Amyloid; Aspartic Acid; Glutamic Acid; Polyesters | 2015 |
Effect of charged amino acid side chain length on lateral cross-strand interactions between carboxylate- and guanidinium-containing residues in a β-hairpin.
Topics: 2-Aminoadipic Acid; Alanine; Arginine; Aspartic Acid; Databases, Protein; Glutamic Acid; Guanidines; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Lysine; Models, Molecular; Protein Folding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Protein Structure, Tertiary; Static Electricity; Thermodynamics | 2015 |
Cerebellar fastigial nuclear glutamatergic neurons regulate immune function via hypothalamic and sympathetic pathways.
Topics: Animals; Aspartic Acid; Axons; Cerebellar Nuclei; Diazooxonorleucine; Enzyme Inhibitors; Female; Glutamic Acid; Glutaminase; Hypothalamic Area, Lateral; Hypothalamus; Immunity; Injections; Killer Cells, Natural; Male; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; T-Lymphocytes; Thalamus | 2015 |
A high-throughput screen for ligand binding reveals the specificities of three amino acid chemoreceptors from Pseudomonas syringae pv. actinidiae.
Topics: Actinidia; Amino Acids; Aspartic Acid; Bacterial Proteins; Chemotaxis; Glutamic Acid; High-Throughput Screening Assays; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Pseudomonas aeruginosa; Pseudomonas syringae | 2015 |
Optimal excitation and emission wavelengths to analyze amino acids and optimize neurotransmitters quantification using precolumn OPA-derivatization by HPLC.
Topics: Animals; Aspartic Acid; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Male; Neurotransmitter Agents; o-Phthalaldehyde; Rats; Rats, Sprague-Dawley; Taurine | 2015 |
Rescue of Na+ affinity in aspartate 928 mutants of Na+,K+-ATPase by secondary mutation of glutamate 314.
Topics: Adenosine Triphosphate; Algorithms; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Biological Transport; Chlorocebus aethiops; COS Cells; Glutamic Acid; Humans; Isoenzymes; Kinetics; Models, Molecular; Mutation; Phosphorylation; Potassium; Protein Structure, Tertiary; Sodium; Sodium-Potassium-Exchanging ATPase; Suppression, Genetic | 2015 |
Decoupling of N-acetyl-aspartate and glutamate within the dorsolateral prefrontal cortex in schizophrenia.
Topics: Adult; Aspartic Acid; Case-Control Studies; Creatine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Male; Neuropsychological Tests; Oxidative Stress; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Schizophrenia | 2015 |
¹H- and ¹³C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain; Carbon-13 Magnetic Resonance Spectroscopy; Creatine; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Inositol; Male; Mice, Transgenic; Mutation; Peptide Fragments; Phosphorylcholine; Proton Magnetic Resonance Spectroscopy | 2015 |
Characterization of Avt1p as a vacuolar proton/amino acid antiporter in Saccharomyces cerevisiae.
Topics: Amino Acid Transport Systems; Amino Acids, Neutral; Antiporters; Aspartic Acid; Biological Transport; gamma-Aminobutyric Acid; Glutamic Acid; Histidine; Intracellular Membranes; Isoleucine; Protons; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Vacuoles | 2015 |
In vivo neurometabolic profiling in patients with spinocerebellar ataxia types 1, 2, 3, and 7.
Topics: Adult; Aspartic Acid; Ataxins; Cohort Studies; Female; Glutamic Acid; Humans; Machado-Joseph Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Principal Component Analysis; Protons; Spinocerebellar Ataxias; Statistics as Topic | 2015 |
Effect of lysine to arginine mutagenesis in the V3 loop of HIV-1 gp120 on viral entry efficiency and neutralization.
Topics: Amino Acid Sequence; Arginine; Aspartic Acid; Cell Line, Transformed; Chemokine CCL5; Chemokine CXCL12; Gene Expression Regulation, Viral; Glutamic Acid; HeLa Cells; HIV Envelope Protein gp120; HIV-1; Host-Pathogen Interactions; Humans; Lysine; Molecular Sequence Data; Mutagenesis; Protein Binding; Protein Structure, Secondary; Receptors, CCR4; Receptors, CCR5; Signal Transduction; Static Electricity; Virus Internalization | 2015 |
Cluster analysis reveals abnormal hippocampal neurometabolic profiles in young people with mood disorders.
Topics: Adolescent; Adult; Aspartic Acid; Cluster Analysis; Creatine; Female; Glutamic Acid; Hippocampus; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mood Disorders; Protons; Psychiatric Status Rating Scales; Young Adult | 2015 |
Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions.
Topics: Analysis of Variance; Animals; Aspartic Acid; Blood Gas Analysis; Blood Pressure; Brain Injuries; Cerebral Cortex; Cortical Spreading Depression; Disease Models, Animal; Electrophysiology; Excitatory Amino Acid Agents; Female; Glutamic Acid; Humans; Infarction, Middle Cerebral Artery; Male; Microelectrodes; Rats; Rats, Sprague-Dawley | 2015 |
The neuroprotective agent CNTF decreases neuronal metabolites in the rat striatum: an in vivo multimodal magnetic resonance imaging study.
Topics: Animals; Aspartic Acid; Astrocytes; Ciliary Neurotrophic Factor; Corpus Striatum; Glutamic Acid; Humans; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Rats, Sprague-Dawley | 2015 |
Monitoring glutamate levels in the posterior cingulate cortex of thyroid dysfunction patients with TE-averaged PRESS at 3T.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Gyrus Cinguli; Humans; Male; Proton Magnetic Resonance Spectroscopy; Thyroid Diseases; Thyroid Gland | 2015 |
Evidence for early neurodegeneration in the cervical cord of patients with primary progressive multiple sclerosis.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Atrophy; Brain; Case-Control Studies; Cervical Cord; Disability Evaluation; Early Diagnosis; Female; Glutamic Acid; Glutamine; Gray Matter; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis, Chronic Progressive; Nerve Degeneration; Proton Magnetic Resonance Spectroscopy; Spinal Cord; White Matter; Young Adult | 2015 |
Alterations in frontal white matter neurochemistry and microstructure in schizophrenia: implications for neuroinflammation.
Topics: Adult; Age Factors; Anisotropy; Aspartic Acid; Case-Control Studies; Choline; Creatine; Diffusion Tensor Imaging; Female; Frontal Lobe; Glutamic Acid; Humans; Inflammation; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuroglia; Schizophrenia; White Matter; Young Adult | 2015 |
Effects of dietary supplementation with glutamate and aspartate on diquat-induced oxidative stress in piglets.
Topics: Amino Acids; Animals; Animals, Newborn; Antioxidants; Aspartic Acid; Body Weight; Cationic Amino Acid Transporter 1; Dietary Supplements; Diquat; Excitatory Amino Acid Transporter 3; Gene Expression; Glutamic Acid; Herbicides; Intestinal Mucosa; Intestines; Malondialdehyde; Nitric Oxide; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase; Swine; Weaning | 2015 |
Reduced levels of NADH-dependent glutamate dehydrogenase decrease the glutamate content of ripe tomato fruit but have no effect on green fruit or leaves.
Topics: Aspartic Acid; Fructose; Fruit; Gene Expression Regulation, Plant; Gene Silencing; Glucose; Glutamate Dehydrogenase (NADP+); Glutamic Acid; Ketoglutaric Acids; MicroRNAs; Mitochondria; NADP; Organ Specificity; Plant Leaves; Plant Proteins; Plants, Genetically Modified; Solanum lycopersicum; Species Specificity | 2015 |
Brain metabolite differences in one-year-old infants born small at term and association with neurodevelopmental outcome.
Topics: Adaptation, Psychological; Aspartic Acid; Brain; Child Development; Child, Preschool; Cognition; Creatine; Female; Fetal Growth Retardation; Glutamic Acid; Glutathione; Humans; Infant; Infant, Small for Gestational Age; Inositol; Language Development; Longitudinal Studies; Magnetic Resonance Spectroscopy; Male; Motor Skills; Social Skills; Term Birth | 2015 |
[Information processing and brain metabolic characteristics in patients at ultra-high risk for endogenous psychosis].
Topics: Adolescent; Adult; Aspartic Acid; Brain; Choline; Evoked Potentials; Female; Glutamic Acid; Glutamine; Humans; Male; Mental Processes; Neuroimaging; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Risk; Thalamus; Young Adult | 2015 |
Chronic Cigarette Smoking in Healthy Middle-Aged Individuals Is Associated With Decreased Regional Brain N-acetylaspartate and Glutamate Levels.
Topics: Adult; Aspartic Acid; Cognition; Decision Making; Female; Glutamic Acid; Gyrus Cinguli; Healthy Volunteers; Humans; Impulsive Behavior; Inositol; Linear Models; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Risk-Taking; Smoking | 2016 |
Spectroscopic markers of memory impairment, symptom severity and age of onset in older people with lifetime depression: Discrete roles of N-acetyl aspartate and glutamate.
Topics: Aged; Aspartic Acid; Case-Control Studies; Cross-Sectional Studies; Depression; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Prefrontal Cortex | 2015 |
Adsorption characteristics of amino acids on to calcium oxalate.
Topics: Adsorption; Aspartic Acid; Calcium Oxalate; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Regression Analysis; Solutions; Urinary Calculi | 2015 |
In Vitro Study of L-Glutamate and L-Glutamine Transport in Retinal Pericytes: Involvement of Excitatory Amino Acid Transporter 1 and Alanine-Serine-Cysteine Transporter 2.
Topics: Alanine; Amino Acid Transport System ASC; Animals; Aspartic Acid; Cysteine; Excitatory Amino Acid Transporter 1; Glutamic Acid; Glutamine; Ion Transport; Male; Minor Histocompatibility Antigens; Pericytes; Rats, Wistar; Retina; Serine | 2015 |
GLU298ASP and 4G/5G Polymorphisms and the Risk of Ischemic Stroke in Young Individuals.
Topics: Adult; Aspartic Acid; Brain Ischemia; Case-Control Studies; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Humans; Male; Mexico; Nitric Oxide Synthase Type III; Plasminogen Activator Inhibitor 1; Polymorphism, Genetic; Stroke | 2015 |
Region-specific cerebral metabolic alterations in streptozotocin-induced type 1 diabetic rats: an in vivo proton magnetic resonance spectroscopy study.
Topics: Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Corpus Striatum; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glutamic Acid; Hippocampus; Hypoglycemic Agents; Inositol; Insulin; Magnetic Resonance Spectroscopy; Neurons; Proton Magnetic Resonance Spectroscopy; Rats; Taurine; Visual Cortex | 2015 |
Cerebellar neurochemical alterations in spinocerebellar ataxia type 14 appear to include glutathione deficiency.
Topics: Adult; Aged; Aspartic Acid; Cerebellum; Cerebral Cortex; Creatine; Female; Glutamic Acid; Glutathione; Humans; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Spinocerebellar Ataxias | 2015 |
Subcortical glutamate mediates the reduction of short-range functional connectivity with age in a developmental cohort.
Topics: Adolescent; Adult; Aspartic Acid; Basal Ganglia; Brain Mapping; Child; Cohort Studies; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memory, Short-Term; Middle Aged; Oxygen; Statistics, Nonparametric; Young Adult | 2015 |
Antibody/receptor protein immunocomplex in human and mouse cortical nerve endings amplifies complement-induced glutamate release.
Topics: Adult; Aged; Animals; Antibodies; Aspartic Acid; Cerebral Cortex; Chemokine CCL5; Complement C1q; Complement Pathway, Classical; Female; Glutamic Acid; Humans; Male; Mice, Inbred C57BL; Middle Aged; Nerve Endings; Receptors, CCR5; Species Specificity; Synaptosomes | 2015 |
Alterations of cerebral glutamate in the euthymic state of patients with bipolar disorder.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Choline; Female; Glutamic Acid; Gyrus Cinguli; Hippocampus; Humans; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy | 2015 |
The positive effect on ketamine as a priming adjuvant in antidepressant treatment.
Topics: Animals; Antidepressive Agents; Anxiety; Aspartic Acid; Behavior, Animal; Brain; Depression; Depressive Disorder, Major; Disease Models, Animal; Drug Therapy, Combination; Fluoxetine; Glutamic Acid; Imipramine; Ketamine; Male; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Wistar; Stress, Psychological | 2015 |
A quantitative analysis of (1)H-MR spectroscopy at 3.0 T of three brain regions from childhood to middle age.
Topics: Adolescent; Adult; Aging; Analysis of Variance; Aspartic Acid; Brain; Child; Creatinine; Female; Glutamic Acid; Glutamine; Healthy Volunteers; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Matrix Metalloproteinase 9; Middle Aged; Young Adult | 2015 |
Associations of hippocampal metabolism and regional brain grey matter in neuroleptic-naïve ultra-high-risk subjects and first-episode schizophrenia.
Topics: Adolescent; Adult; Aspartic Acid; Brain Mapping; Female; Frontal Lobe; Glutamic Acid; Gray Matter; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Prodromal Symptoms; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Risk; Schizophrenia; Young Adult | 2015 |
(1)H NMR-Based Metabolomics and Neurotoxicity Study of Cerebrum and Cerebellum in Rats Treated with Cinnabar, a Traditional Chinese Medicine.
Topics: Animals; Aspartic Acid; Cell Death; Cerebellum; Cerebrum; Choline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Inositol; Male; Medicine, Chinese Traditional; Membrane Fluidity; Mercury Compounds; Metabolomics; Neurons; Organ Specificity; Rats; Rats, Wistar; Taurine | 2015 |
SPAK and OSR1 Sensitivity of Excitatory Amino Acid Transporter EAAT3.
Topics: Animals; Aspartic Acid; Excitatory Amino Acid Transporter 3; Glutamic Acid; Humans; Mice; Oocytes; Patch-Clamp Techniques; Protein Serine-Threonine Kinases; RNA, Complementary; Water; Xenopus laevis | 2015 |
Mutagenesis study to disrupt electrostatic interactions on the twofold symmetry interface of Escherichia coli bacterioferritin.
Topics: Amino Acid Substitution; Arginine; Aspartic Acid; Escherichia coli Proteins; Glutamic Acid; Metalloproteins; Microscopy, Electron, Transmission; Multiprotein Complexes; Mutagenesis, Site-Directed; Protein Folding; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Secondary; Static Electricity; Temperature | 2015 |
Residues in the acetyl CoA binding site of pyruvate carboxylase involved in allosteric regulation.
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Allosteric Regulation; Allosteric Site; Amino Acid Substitution; Arginine; Aspartic Acid; Bacterial Proteins; Bicarbonates; Biocatalysis; Glutamic Acid; Kinetics; Magnesium; Models, Molecular; Molecular Conformation; Mutagenesis, Site-Directed; Mutant Proteins; Protein Stability; Pyruvate Carboxylase; Pyruvic Acid; Recombinant Proteins; Rhizobium etli | 2015 |
Insight into Trypsin Miscleavage: Comparison of Kinetic Constants of Problematic Peptide Sequences.
Topics: Amino Acid Motifs; Amino Acid Sequence; Aspartic Acid; Glutamic Acid; Kinetics; Sequence Analysis, Protein; Substrate Specificity; Trypsin | 2015 |
Effects of phosphoenolpyruvate carboxylase desensitization on glutamic acid production in Corynebacterium glutamicum ATCC 13032.
Topics: Aspartic Acid; Bioreactors; Biotin; Citric Acid Cycle; Corynebacterium glutamicum; Feedback, Physiological; Glucose; Glutamic Acid; Ketoglutaric Acids; Phosphoenolpyruvate Carboxylase; Pyruvate Kinase | 2016 |
Viability assessment of magnetic resonance spectroscopy for the detection of minimal hepatic encephalopathy severity.
Topics: Adult; Aspartic Acid; Basal Ganglia; Brain; Cognition; Creatine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Hepatic Encephalopathy; Hepatitis; Humans; Inositol; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests | 2015 |
Is Aspartate an Excitatory Neurotransmitter?
Topics: Action Potentials; Animals; Aspartic Acid; CA1 Region, Hippocampal; Electric Stimulation; Evoked Potentials; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Mice; Mice, Knockout; Neurons; RNA, Messenger; Statistics, Nonparametric; Vesicular Glutamate Transport Protein 1 | 2015 |
Analysis of Conserved Glutamate and Aspartate Residues in Drosophila Rhodopsin 1 and Their Influence on Spectral Tuning.
Topics: Animals; Aspartic Acid; Blotting, Western; Conserved Sequence; Drosophila melanogaster; Drosophila Proteins; Glutamic Acid; Microspectrophotometry; Mutation; Opsins; Phylogeny; Protein Structure, Secondary; Retinal Degeneration; Rhodopsin | 2015 |
Acidic Residues in the Hfq Chaperone Increase the Selectivity of sRNA Binding and Annealing.
Topics: Arginine; Aspartic Acid; Base Pairing; Base Sequence; DNA Footprinting; Electrophoretic Mobility Shift Assay; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Glutamic Acid; Host Factor 1 Protein; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; RNA, Bacterial; RNA, Messenger; RNA, Small Untranslated | 2015 |
In Vivo Longitudinal (1)H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1 T.
Topics: Animals; Aspartic Acid; Brain Chemistry; Cerebellum; Glutamic Acid; Hippocampus; Inositol; Lactic Acid; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Transgenic; Prion Diseases; Prion Proteins; Prions | 2015 |
Electrostatics of the photosynthetic bacterial reaction center. Protonation of Glu L 212 and Asp L 213 - A new method of calculation.
Topics: Aspartic Acid; Glutamic Acid; Hydrogen Bonding; Photosynthetic Reaction Center Complex Proteins; Protons; Static Electricity | 2015 |
Dysfunctional TCA-Cycle Metabolism in Glutamate Dehydrogenase Deficient Astrocytes.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Astrocytes; Carbon Dioxide; Cells, Cultured; Cerebral Cortex; Citric Acid Cycle; Gene Knockdown Techniques; Glucose; Glutamate Dehydrogenase; Glutamic Acid; Isoleucine; Lactic Acid; Mice; RNA, Small Interfering; Tricarboxylic Acids | 2015 |
Intracellular levels of glutamate in swollen astrocytes are preserved via neurotransmitter reuptake and de novo synthesis: implications for hyponatremia.
Topics: Animals; Aspartic Acid; Astrocytes; Biological Transport; Cell Shape; Cells, Cultured; Cytoplasm; Glutamic Acid; Hyponatremia; Neurotransmitter Agents; Rats, Sprague-Dawley; Synaptic Transmission | 2015 |
Dietary supplementation with L-glutamate and L-aspartate alleviates oxidative stress in weaned piglets challenged with hydrogen peroxide.
Topics: Animal Feed; Animals; Aspartic Acid; Dietary Supplements; Female; Glutamic Acid; Hydrogen Peroxide; Male; Oxidative Stress; Swine; Weaning | 2016 |
Glutamatergic dysfunction linked to energy and membrane lipid metabolism in frontal and anterior cingulate cortices of never treated first-episode schizophrenia patients.
Topics: Adult; Analysis of Variance; Aspartic Acid; Creatine; Female; Glutamic Acid; Gyrus Cinguli; Humans; Lipid Metabolism; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Membrane Lipids; Phospholipids; Phosphorus Isotopes; Protons; Psychiatric Status Rating Scales; Schizophrenia; Young Adult | 2015 |
The two interfaces of the STAT1 N-terminus exhibit opposite functions in IFNγ-regulated gene expression.
Topics: Aspartic Acid; Cell Nucleus; DNA; Gene Expression Regulation; Glutamic Acid; HeLa Cells; Humans; Interferon-gamma; Models, Molecular; Mutant Proteins; Mutation; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Multimerization; Protein Stability; Protein Structure, Tertiary; STAT1 Transcription Factor; Transcription, Genetic | 2015 |
Single-voxel (1)H spectroscopy in the human hippocampus at 3 T using the LASER sequence: characterization of neurochemical profile and reproducibility.
Topics: Adult; Aspartic Acid; Choline; Creatine; Feasibility Studies; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Lactates; Magnetic Resonance Spectroscopy; Male; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Young Adult | 2015 |
Transient CNS responses to repeated binge ethanol treatment.
Topics: Animals; Aspartic Acid; Binge Drinking; Brain; Choline; Creatine; Ethanol; Glutamic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Wistar | 2016 |
Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis.
Topics: Adult; Aspartic Acid; Brain; Disability Evaluation; Disabled Persons; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Neuropsychological Tests; Severity of Illness Index | 2015 |
Elevated Myo-Inositol, Choline, and Glutamate Levels in the Associative Striatum of Antipsychotic-Naive Patients With First-Episode Psychosis: A Proton Magnetic Resonance Spectroscopy Study With Implications for Glial Dysfunction.
Topics: Adult; Aspartic Acid; Choline; Corpus Striatum; Glutamic Acid; Glutamine; Humans; Inositol; Neuroglia; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Schizophrenia | 2016 |
Metabolic mapping reveals sex-dependent involvement of default mode and salience network in alexithymia.
Topics: Adult; Affective Symptoms; Aspartic Acid; Brain Mapping; Emotions; Female; Glutamic Acid; Gyrus Cinguli; Humans; Male; Middle Aged; Nerve Net; Sex Characteristics | 2016 |
Respiration and substrate transport rates as well as reactive oxygen species production distinguish mitochondria from brain and liver.
Topics: Animals; Aspartic Acid; Biological Transport; Brain; Cell Respiration; Dicarboxylic Acid Transporters; Electron Transport Chain Complex Proteins; Enzyme Inhibitors; Gene Expression Regulation; Glutamic Acid; Kinetics; Liver; Malates; Membrane Potential, Mitochondrial; Mice; Mitochondria, Liver; NAD; Organ Specificity; Reactive Oxygen Species; Succinic Acid | 2015 |
Mechanisms regulating spill-over of synaptic glutamate to extrasynaptic NMDA receptors in mouse substantia nigra dopaminergic neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Dizocilpine Maleate; Dopaminergic Neurons; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Synapses; Xanthenes | 2015 |
Saccharomyces cerevisiae lysophospholipid acyltransferase, Lpt1, requires Asp146 and Glu297 for catalysis.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Acyl Coenzyme A; Amino Acid Sequence; Aspartic Acid; Biocatalysis; Conserved Sequence; Glutamic Acid; Kinetics; Lysophospholipids; Molecular Sequence Data; Mutagenesis, Site-Directed; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2015 |
Methylphenidate Increases Glutamate Uptake in Bergmann Glial Cells.
Topics: Animals; Aspartic Acid; Cell Line; Cell Membrane; Chick Embryo; Dopamine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Transporter 1; Glutamic Acid; Methylphenidate; Neuroglia; RNA; Up-Regulation | 2015 |
Reduced cortical thickness in patients with acute-on-chronic liver failure due to non-alcoholic etiology.
Topics: Acute-On-Chronic Liver Failure; Adult; Aspartic Acid; Brain; Case-Control Studies; Cognition; Cognition Disorders; Female; Follow-Up Studies; Glutamic Acid; Glutamine; Humans; Inositol; Liver; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Software; Treatment Outcome | 2015 |
A novel method for simultaneous glutamate and extracellular activity measurement in brain slices with high temporal resolution.
Topics: 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Brain; Electrophysiology; Extracellular Space; Fluorescent Dyes; Glutamic Acid; Hippocampus; Male; Rats; Rats, Wistar | 2015 |
Structural basis for the relaxed substrate selectivity of Leishmania mexicana broad specificity aminotransferase.
Topics: Arginine; Aspartic Acid; Crystallization; Crystallography, X-Ray; Dimerization; Glutamic Acid; Leishmania mexicana; Leishmaniasis, Cutaneous; Protein Structure, Tertiary; Protozoan Proteins; Pyridoxal Phosphate; Substrate Specificity; Transaminases | 2015 |
Longitudinal in vivo maturational changes of metabolites in the prefrontal cortex of rats exposed to polyinosinic-polycytidylic acid in utero.
Topics: Age Factors; Animals; Aspartic Acid; Female; Gestational Age; Glutamic Acid; Glutathione; Interferon Inducers; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Poly I-C; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Protons; Rats; Rats, Sprague-Dawley; Recognition, Psychology; Taurine | 2015 |
Molecular Determinants of Substrate Specificity in Sodium-coupled Glutamate Transporters.
Topics: Amino Acid Substitution; Aspartic Acid; Brain; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Ion Transport; Mutation, Missense; Nerve Tissue Proteins; Protein Structure, Secondary; Substrate Specificity | 2015 |
Synthesis of stable C-linked ferrocenyl amino acids and their use in solution-phase peptide synthesis.
Topics: Amino Acids; Aspartic Acid; Ferrous Compounds; Glutamic Acid; Molecular Structure; Organometallic Compounds; Peptides | 2015 |
Concentration of Umami Compounds in Pork Meat and Cooking Juice with Different Cooking Times and Temperatures.
Topics: Adenosine Monophosphate; Amino Acids; Animals; Aspartic Acid; Cooking; Glutamic Acid; Hot Temperature; Humans; Inosine Monophosphate; Nucleosides; Nucleotides; Proteolysis; Red Meat; Swine; Taste; Temperature; Water | 2015 |
Modulation of Self-Assembly Process of Fibroin: An Insight for Regulating the Conformation of Silk Biomaterials.
Topics: Animals; Aspartic Acid; Bombyx; Calcium; Cations, Divalent; Circular Dichroism; Fibroins; Glutamic Acid; Molecular Dynamics Simulation; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Static Electricity | 2015 |
Establishing the catalytic mechanism of human pancreatic α-amylase with QM/MM methods.
Topics: Aspartic Acid; Biocatalysis; Glutamic Acid; Humans; Molecular Dynamics Simulation; Molecular Structure; Pancreatic alpha-Amylases; Quantum Theory | 2015 |
Enhancing constant-pH simulation in explicit solvent with a two-dimensional replica exchange method.
Topics: Animals; Aspartic Acid; Cardiotoxins; Glutamic Acid; Hydrogen-Ion Concentration; Lysine; Molecular Dynamics Simulation; Peptides; Snakes; Solvents; Thermodynamics | 2015 |
Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate.
Topics: Animals; Aspartic Acid; Brain; Brain Chemistry; Enzyme-Linked Immunosorbent Assay; gamma-Aminobutyric Acid; Gastrointestinal Microbiome; Glutamic Acid; Lacticaseibacillus rhamnosus; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred BALB C; Probiotics | 2016 |
Stable isotope studies reveal pathways for the incorporation of non-essential amino acids in Acyrthosiphon pisum (pea aphids).
Topics: Amino Acids; Animals; Aphids; Asparagine; Aspartic Acid; Buchnera; Carbon Isotopes; Glutamic Acid; Glutamine; Nitrogen; Nitrogen Isotopes; Symbiosis | 2015 |
Investigation of NAA and NAAG dynamics underlying visual stimulation using MEGA-PRESS in a functional MRS experiment.
Topics: Adult; Aspartic Acid; Brain; Dipeptides; Female; Glutamic Acid; Healthy Volunteers; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurons; Neuropeptides; Vision, Ocular; Young Adult | 2016 |
Transport and channel functions in EAATs: the missing link.
Topics: Amino Acid Substitution; Arginine; Aspartic Acid; Biological Transport; Excitatory Amino Acid Transporter 1; Gene Expression Regulation; Glutamic Acid; Humans; Ion Channel Gating; Molecular Dynamics Simulation; Neuroglia; Neurons; Point Mutation; Protein Conformation; Sodium | 2016 |
Roles of Asp179 and Glu270 in ADP-Ribosylation of Actin by Clostridium perfringens Iota Toxin.
Topics: Actins; Adenosine Diphosphate Ribose; ADP Ribose Transferases; Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Bacterial Toxins; Glutamic Acid; Humans; Models, Molecular; Molecular Sequence Data; Protein Conformation; Saccharomyces cerevisiae | 2015 |
A combined diffusion tensor imaging and magnetic resonance spectroscopy study of patients with schizophrenia.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Creatine; Diffusion Tensor Imaging; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Multimodal Imaging; Myelin Sheath; Psychotic Disorders; Schizophrenia; White Matter | 2016 |
The ratio of N-acetyl aspartate to glutamate correlates with disease duration of amyotrophic lateral sclerosis.
Topics: Aged; Aging; Amyotrophic Lateral Sclerosis; Aspartic Acid; Biomarkers; Cell Death; Cross-Sectional Studies; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Neurons | 2016 |
Effects of paternal and peripubertal stress on aggression, anxiety, and metabolic alterations in the lateral septum.
Topics: Age Factors; Aggression; Animals; Animals, Newborn; Anxiety Disorders; Aspartic Acid; Creatine; Disease Models, Animal; Female; Glutamate Decarboxylase; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Maze Learning; Phosphorylcholine; Rats; Rats, Wistar; Septal Nuclei; Stress, Psychological; Tritium | 2016 |
Hippocampal neurochemical markers in bipolar disorder patients following the first-manic episode: A prospective 12-month proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Male; Prospective Studies; Proton Magnetic Resonance Spectroscopy; Young Adult | 2017 |
Resolution of High-Frequency Mesoscale Intracortical Maps Using the Genetically Encoded Glutamate Sensor iGluSnFR.
Topics: Animals; Aspartic Acid; Brain; Brain Mapping; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Escherichia coli Proteins; Glutamic Acid; Green Fluorescent Proteins; Homeodomain Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Physical Stimulation; Recombinant Fusion Proteins; Transcription Factors; Voltage-Sensitive Dye Imaging | 2016 |
Associations Between Recent Heavy Drinking and Dorsal Anterior Cingulate N-Acetylaspartate and Glutamate Concentrations in Non-Treatment-Seeking Individuals with Alcohol Dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Aspartic Acid; Biomarkers; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Young Adult | 2016 |
Structural Insight into Substrate Selectivity of Erwinia chrysanthemi L-asparaginase.
Topics: Asparaginase; Aspartic Acid; Crystallography, X-Ray; Dickeya chrysanthemi; Glutamic Acid; Humans; Models, Molecular; Protein Conformation; Substrate Specificity | 2016 |
A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase.
Topics: Aspartic Acid; Crystallography, X-Ray; Glutamic Acid; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Tertiary; Protein-Arginine N-Methyltransferases; Protozoan Proteins; S-Adenosylhomocysteine; Substrate Specificity; Trypanosoma brucei brucei | 2016 |
Failure and rescue of preconditioning-induced neuroprotection in severe stroke-like insults.
Topics: 4-Aminopyridine; Animals; Aspartic Acid; Bicuculline; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Dizocilpine Maleate; Glucose; Glutamic Acid; Ischemic Preconditioning; Neurons; Neuroprotective Agents; Ouabain; Rats; Stroke; Time Factors | 2016 |
Prefrontal NAA and Glx Levels in Different Stages of Psychotic Disorders: a 3T 1H-MRS Study.
Topics: Adolescent; Adult; Age Factors; Antipsychotic Agents; Aspartic Acid; Case-Control Studies; Disease Progression; Female; Glutamic Acid; Glutamine; Humans; Male; Middle Aged; Neurotransmitter Agents; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Regression Analysis; Risk; Severity of Illness Index; Time Factors | 2016 |
Aspartate Rescues S-phase Arrest Caused by Suppression of Glutamine Utilization in KRas-driven Cancer Cells.
Topics: Aspartic Acid; Ataxia Telangiectasia Mutated Proteins; Citric Acid Cycle; G1 Phase Cell Cycle Checkpoints; Glutamic Acid; Humans; MCF-7 Cells; Proto-Oncogene Proteins p21(ras); Purine Nucleotides; Pyrimidine Nucleotides; S Phase Cell Cycle Checkpoints | 2016 |
Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.
Topics: Adult; Aging; Antipsychotic Agents; Aspartic Acid; Choline; Creatine; Dipeptides; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Gyrus Cinguli; Humans; Inositol; Male; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Schizophrenia | 2016 |
In vivo proton magnetic resonance spectroscopy (1H-MRS) evaluation of the metabolite concentration of optic radiation in primary open angle glaucoma.
Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Biomarkers; Choline; Creatine; Cross-Sectional Studies; Female; Glaucoma, Open-Angle; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nerve Fibers; Optic Nerve; Proton Magnetic Resonance Spectroscopy; Radiation Dosage; Young Adult | 2016 |
L-DOPA Reverses the Increased Free Amino Acids Tissue Levels Induced by Dopamine Depletion and Rises GABA and Tyrosine in the Striatum.
Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; Forelimb; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Levodopa; Mice; Oxidopamine; Rotarod Performance Test; Taurine; Tyrosine | 2016 |
Imaging increased glutamate in children with Sturge-Weber syndrome: Association with epilepsy severity.
Topics: Aspartic Acid; Brain; Child; Child, Preschool; Creatine; Epilepsy; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Glutamic Acid; Humans; Infant; Magnetic Resonance Imaging; Male; Multivariate Analysis; Positron-Emission Tomography; Proton Magnetic Resonance Spectroscopy; Radiopharmaceuticals; Regression Analysis; Severity of Illness Index; Sturge-Weber Syndrome | 2016 |
Nutrient assessment of olive leaf residues processed by solid-state fermentation as an innovative feedstuff additive.
Topics: Animal Feed; Animals; Aspartic Acid; Aspergillus niger; Aspergillus oryzae; Chickens; Dietary Supplements; Fermentation; Glutamic Acid; Olea; Plant Leaves; Trichoderma | 2016 |
Detection of four different amino acid neurotransmitters in cultured rat neurons and the culture medium by precolumn derivatization high-performance liquid chromatography.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media, Conditioned; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Neurons; Rats; Rats, Wistar | 2016 |
Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children.
Topics: Adolescent; AIDS Dementia Complex; Aspartic Acid; Brain; CD4 Lymphocyte Count; Child; Choline; Cognition Disorders; Cohort Studies; Creatine; Cross-Sectional Studies; Female; Glutamic Acid; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Inositol; Magnetic Resonance Spectroscopy; Male; Neurofilament Proteins; Neuropsychological Tests; Reference Values; tau Proteins | 2016 |
Glutamate Receptor Stimulation Up-Regulates Glutamate Uptake in Human Müller Glia Cells.
Topics: Aspartic Acid; Cells, Cultured; Ependymoglial Cells; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Neuroglia; Receptors, Glutamate; Up-Regulation | 2016 |
Brain metabolite levels in recently sober individuals with alcohol use disorder: Relation to drinking variables and relapse.
Topics: Adult; Alcohol Abstinence; Alcohol Drinking; Alcoholism; Aspartic Acid; Brain; Choline; Chronic Disease; Creatine; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Recurrence | 2016 |
Analysis of Potential Amino Acid Biomarkers in Brain Tissue and the Effect of Galangin on Cerebral Ischemia.
Topics: Alanine; Amino Acid Transport Systems, Neutral; Animals; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Excitatory Amino Acid Transporter 3; Flavonoids; Free Radical Scavengers; Glutamate Dehydrogenase; Glutamic Acid; Humans; Protein Interaction Maps; Rats; Transferases (Other Substituted Phosphate Groups) | 2016 |
Oxygen-glucose deprivation enhancement of cell death/apoptosis in PC12 cells and hippocampal neurons correlates with changes in neuronal excitatory amino acid neurotransmitter signaling and potassium currents.
Topics: Animals; Apoptosis; Aspartic Acid; Cell Death; Glutamic Acid; Hippocampus; Neurons; PC12 Cells; Potassium Channels, Voltage-Gated; Rats; Rats, Wistar; Receptors, AMPA; Signal Transduction | 2016 |
Combination of aspartic acid and glutamic acid inhibits tumor cell proliferation.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glutamic Acid; Humans; Liver Neoplasms; Placenta; Pregnancy; Proto-Oncogene Proteins c-akt; Rabbits; Signal Transduction; Xenograft Model Antitumor Assays | 2016 |
Microfluidic Platform with In-Chip Electrophoresis Coupled to Mass Spectrometry for Monitoring Neurochemical Release from Nerve Cells.
Topics: Animals; Aspartic Acid; Dopamine; Electrophoresis; Glutamic Acid; Lab-On-A-Chip Devices; Microfluidics; Nanostructures; Neurons; Neurotransmitter Agents; PC12 Cells; Potassium Chloride; Rats; Serotonin; Spectrometry, Mass, Electrospray Ionization | 2016 |
A 'complex' of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients.
Topics: Adolescent; Adult; Analysis of Variance; Aspartic Acid; Cohort Studies; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Migraine Disorders; Proton Magnetic Resonance Spectroscopy; Young Adult | 2016 |
Coupling of glutamate and glucose uptake in cultured Bergmann glial cells.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Carrier Proteins; Cells, Cultured; Chick Embryo; Energy Metabolism; Excitatory Amino Acids; Glucose; Glutamic Acid; Neuroglia; Neurotransmitter Agents; Protein Kinase C; Signal Transduction; Sodium-Potassium-Exchanging ATPase | 2016 |
Exercise increases mitochondrial glutamate oxidation in the mouse cerebral cortex.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Cerebral Cortex; Glutamate Dehydrogenase; Glutamic Acid; Ketoglutaric Acids; Malates; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxygen Consumption; Physical Conditioning, Animal | 2016 |
A novel multi-biofunctional protein from brown rice hydrolysed by endo/endo-exoproteases.
Topics: Adult; Aspartic Acid; Chemical Phenomena; Endopeptidases; Exopeptidases; Female; Glutamic Acid; Glycine; Guanosine Monophosphate; Humans; Hydrolysis; Hydrophobic and Hydrophilic Interactions; Inosine Monophosphate; Leucine; Male; Molecular Weight; Oryza; Plant Proteins; Sodium Glutamate; Taste; Valine; Volatile Organic Compounds | 2016 |
Neuronal activity mediated regulation of glutamate transporter GLT-1 surface diffusion in rat astrocytes in dissociated and slice cultures.
Topics: 4-Aminopyridine; Anesthetics, Local; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Embryo, Mammalian; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Neurons; Organ Culture Techniques; Potassium Channel Blockers; Rats; Rats, Transgenic; Tetrodotoxin | 2016 |
Molecular Investigation of the Mechanism of Non-Enzymatic Hydrolysis of Proteins and the Predictive Algorithm for Susceptibility.
Topics: Algorithms; Aspartic Acid; Glutamic Acid; Humans; Hydrogen Bonding; Hydrolysis; Models, Molecular; Molecular Dynamics Simulation; Protein Conformation; Proteins; Thermodynamics | 2016 |
Single exposure to cocaine impairs aspartate uptake in the pre-frontal cortex via dopamine D1-receptor dependent mechanisms.
Topics: Adenylyl Cyclases; Animals; Aspartic Acid; Cocaine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Extracellular Space; Gene Expression; Glutamic Acid; Mice; Phosphorylation; Prefrontal Cortex; Receptors, Dopamine D1; Serine; Signal Transduction; Time Factors | 2016 |
Sea cucumber peptides exert anti-inflammatory activity through suppressing NF-κB and MAPK and inducing HO-1 in RAW264.7 macrophages.
Topics: Animals; Anti-Inflammatory Agents; Aspartic Acid; Cell Survival; Cytokines; Glutamic Acid; Glycine; Heme Oxygenase-1; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Mitogen-Activated Protein Kinases; Molecular Weight; NF-kappa B; Nitric Oxide Synthase Type II; Peptides; Phosphorylation; RAW 264.7 Cells; Sea Cucumbers | 2016 |
[Measurement of the metabolites in the cortical masticatory area of patients with sleep bruxism: a magnetic resonance spectroscopy study].
Topics: Analysis of Variance; Aspartic Acid; Case-Control Studies; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Masticatory Muscles; Motor Neurons; Sleep Bruxism | 2016 |
Cortical thickness and metabolite concentration in chronic stroke and the relationship with motor function.
Topics: Aged; Aged, 80 and over; Aspartic Acid; Cerebral Cortex; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Motor Activity; Proton Magnetic Resonance Spectroscopy; Stroke; Upper Extremity | 2016 |
Silver-Lactoferrin Nanocomplexes as a Potent Antimicrobial Agent.
Topics: Animals; Anti-Infective Agents; Aspartic Acid; Bacteria; Binding Sites; Cattle; Drug Design; Glutamic Acid; Ions; Lactoferrin; Metal Nanoparticles; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Nanotechnology; Protein Binding; Pseudomonas aeruginosa; Quantum Theory; Silver; Software; Surface Properties | 2016 |
Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae.
Topics: Arabidopsis; Arabidopsis Proteins; Aspartic Acid; Catalytic Domain; Glutamic Acid; Mutagenesis; Oxidoreductases, N-Demethylating; Protein Structure, Secondary; Salt Tolerance; Species Specificity | 2016 |
Influence of Glu/Arg, Asp/Arg, and Glu/Lys Salt Bridges on α-Helical Stability and Folding Kinetics.
Topics: Amino Acid Sequence; Arginine; Aspartic Acid; Circular Dichroism; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Least-Squares Analysis; Lysine; Molecular Dynamics Simulation; Peptides; Protein Folding; Protein Stability; Protein Structure, Secondary; Spectrum Analysis; Static Electricity; Thermodynamics | 2016 |
The recovery trajectory of adolescent social defeat stress-induced behavioral, (1)H-MRS metabolites and myelin changes in Balb/c mice.
Topics: Animals; Aspartic Acid; Creatinine; Down-Regulation; Glutamic Acid; Glutamine; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Myelin Basic Protein; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Social Behavior; Stress, Psychological; Up-Regulation | 2016 |
Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity.
Topics: Amino Acid Transport System X-AG; Animals; Antineoplastic Agents; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Cytokines; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Glutamic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Oncostatin M; Oncostatin M Receptor beta Subunit; Retroviridae Proteins, Oncogenic; Signal Transduction | 2016 |
Neurochemical correlates of internet game play in adolescents with attention deficit hyperactivity disorder: A proton magnetic resonance spectroscopy (MRS) study.
Topics: Adolescent; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Brain; Glutamic Acid; Glutamine; Humans; Internet; Male; Proton Magnetic Resonance Spectroscopy; Video Games | 2016 |
Advanced MRI increases the diagnostic accuracy of recurrent glioblastoma: Single institution thresholds and validation of MR spectroscopy and diffusion weighted MR imaging.
Topics: Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Cohort Studies; Diffusion Magnetic Resonance Imaging; Female; Glioblastoma; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Middle Aged; ROC Curve; Statistics, Nonparametric | 2016 |
(1)H-MRS metabolites in adults with Down syndrome: Effects of dementia.
Topics: Activities of Daily Living; Adult; Analysis of Variance; Aspartic Acid; Dementia; Down Syndrome; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Male; Middle Aged; Neuropsychological Tests; Proton Magnetic Resonance Spectroscopy; Psychiatric Status Rating Scales; Surveys and Questionnaires | 2016 |
Prefrontal inositol levels and implicit decision-making in healthy individuals and depressed patients.
Topics: Adult; Aspartic Acid; Decision Making; Delay Discounting; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Learning; Magnetic Resonance Imaging; Male; Middle Aged; Nervous System Physiological Phenomena; Neuroimaging; Neurons; Neuropsychological Tests; Prefrontal Cortex; Reproducibility of Results; Task Performance and Analysis | 2016 |
Repeated ketamine treatment induces sex-specific behavioral and neurochemical effects in mice.
Topics: Animals; Antidepressive Agents; Anxiety; Aspartic Acid; Depression; Female; Glutamic Acid; Hippocampus; Hydroxyindoleacetic Acid; Ketamine; Male; Mice; Mice, Inbred C57BL; Serotonin; Sex Characteristics; SNARE Proteins; Synapsins; Syntaxin 1 | 2016 |
Integrative Network-based Analysis of Magnetic Resonance Spectroscopy and Genome Wide Expression in Glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Computational Biology; Creatine; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; Glioblastoma; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasm Proteins; Neurons; Oligodendroglia; Prognosis; Prospective Studies; Survival Analysis | 2016 |
Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.
Topics: Amino Acid Sequence; Animals; Apoptosis; Aspartic Acid; Caspases; Conserved Sequence; Crystallography, X-Ray; Glutamic Acid; HEK293 Cells; Humans; Kinetics; Mice; Peptides; Phosphorylation; Phosphoserine; Proteolysis; Substrate Specificity | 2016 |
Nicotinic receptor activation contrasts pathophysiological bursting and neurodegeneration evoked by glutamate uptake block on rat hypoglossal motoneurons.
Topics: Action Potentials; Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Brain Stem; Endoplasmic Reticulum Stress; Glucosyltransferases; Glutamic Acid; Hypoglossal Nerve; Motor Neurons; Neurodegenerative Diseases; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Nicotinic | 2016 |
Investigation of the Roles of Allosteric Domain Arginine, Aspartate, and Glutamate Residues of Rhizobium etli Pyruvate Carboxylase in Relation to Its Activation by Acetyl CoA.
Topics: Acetyl Coenzyme A; Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Arginine; Aspartic Acid; Bacterial Proteins; Enzyme Activation; Glutamic Acid; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Pyruvate Carboxylase; Recombinant Proteins; Rhizobium etli | 2016 |
Using Surface Scans for the Evaluation of Halogen Bonds toward the Side Chains of Aspartate, Asparagine, Glutamate, and Glutamine.
Topics: Amides; Amino Acids; Asparagine; Aspartic Acid; Carboxylic Acids; Crystallography, X-Ray; Drug Design; Glutamic Acid; Glutamine; Halogens; Models, Molecular; Molecular Conformation; Solvents | 2016 |
Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid β- and TNFα- Mediated Synaptic Plasticity Disruption in the Rat Hippocampus.
Topics: Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartate Aminotransferase, Cytoplasmic; Aspartic Acid; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hippocampus; Homeostasis; Humans; Injections, Intraperitoneal; Male; Oxaloacetic Acid; Peptide Fragments; Rats; Rats, Wistar; Synapses; Time Factors; Tumor Necrosis Factor-alpha | 2017 |
Case control study: magnetic resonance spectroscopy of brain in HIV infected patients.
Topics: Adult; Aspartic Acid; Basal Ganglia; Case-Control Studies; Choline; Creatine; Dipeptides; Female; Frontal Lobe; Glutamic Acid; Glutamine; HIV Infections; Humans; Inositol; Lipid Metabolism; Macromolecular Substances; Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging; Proton Magnetic Resonance Spectroscopy; White Matter | 2016 |
A single mutation converts bacterial Na(+) -transporting rhodopsin into an H(+) transporter.
Topics: Aspartic Acid; Escherichia coli; Flavobacteriaceae; Glutamic Acid; Hydrogen; Ion Transport; Ions; Membrane Transport Proteins; Mutation; Rhodopsins, Microbial; Sodium | 2016 |
Adverse childhood experiences associate to reduced glutamate levels in the hippocampus of patients affected by mood disorders.
Topics: Adolescent; Adult; Adult Survivors of Child Abuse; Aspartic Acid; Creatine; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Linear Models; Male; Middle Aged; Mood Disorders; Proton Magnetic Resonance Spectroscopy; Young Adult | 2016 |
Analysis of proton wires in the enzyme active site suggests a mechanism of c-di-GMP hydrolysis by the EAL domain phosphodiesterases.
Topics: Amino Acid Substitution; Aspartic Acid; Catalytic Domain; Cyclic GMP; Escherichia coli; Escherichia coli Proteins; Gene Expression; Glutamic Acid; Hydrogen Bonding; Hydrolysis; Kinetics; Molecular Dynamics Simulation; Phosphoric Diester Hydrolases; Phosphorus; Protein Structure, Secondary; Protons; Quantum Theory; Structure-Activity Relationship; Thermodynamics; Water | 2016 |
Exploring the mechanism of DNA polymerases by analyzing the effect of mutations of active site acidic groups in Polymerase β.
Topics: Alanine; Amino Acid Motifs; Amino Acid Substitution; Aspartic Acid; DNA Polymerase beta; Gene Expression; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Molecular Dynamics Simulation; Mutation; Protein Domains; Protein Structure, Secondary; Protons; Quantum Theory; Structure-Activity Relationship; Thermodynamics | 2016 |
Structural model of amyloid fibrils for amyloidogenic peptide from Bgl2p-glucantransferase of S. cerevisiae cell wall and its modifying analog. New morphology of amyloid fibrils.
Topics: Amino Acid Sequence; Amino Acid Substitution; Ammonia; Amyloid; Amyloidogenic Proteins; Aspartic Acid; Cell Wall; Crystallography, X-Ray; Glucan Endo-1,3-beta-D-Glucosidase; Glutamic Acid; Hydrogen-Ion Concentration; Models, Molecular; Molecular Structure; Peptide Fragments; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Solid-Phase Synthesis Techniques | 2016 |
Glutamatergic and Neuronal Dysfunction in Gray and White Matter: A Spectroscopic Imaging Study in a Large Schizophrenia Sample.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Gray Matter; Humans; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Schizophrenia; White Matter; Young Adult | 2017 |
Dynamic transition of neuronal firing induced by abnormal astrocytic glutamate oscillation.
Topics: Aspartic Acid; Astrocytes; Glutamic Acid; Hippocampus; Humans; Neuroglia; Neurons; Receptors, N-Methyl-D-Aspartate; Seizures; Synapses | 2016 |
Whole-brain patterns of (1)H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Lewy Body Disease; Magnetic Resonance Imaging; Male; Proton Magnetic Resonance Spectroscopy | 2016 |
Pre-formulation and systematic evaluation of amino acid assisted permeability of insulin across in vitro buccal cell layers.
Topics: Aspartic Acid; Cell Line, Tumor; Cell Membrane; Cell Membrane Permeability; Cell Survival; Deoxycholic Acid; Electric Impedance; Glutamic Acid; Histidine; Humans; Hydrogen-Ion Concentration; Insulin; Kinetics; Lysine; Mouth Mucosa | 2016 |
Mechanistic study of competitive releases of H
Topics: Ammonia; Anions; Aspartic Acid; Carbon Dioxide; Glutamic Acid; Models, Molecular; Molecular Conformation; Protons; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Water | 2017 |
1.65 Å resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae.
Topics: Amino Acid Motifs; Aspartic Acid; Bacterial Proteins; Binding Sites; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Gene Expression; Glutamic Acid; Models, Molecular; Plasmids; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Recombinant Fusion Proteins; Transcription Factors; Vibrio cholerae | 2016 |
Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate.
Topics: Animals; Aspartic Acid; Brain; Choline; Creatine; Echoencephalography; Female; Fetus; Glutamic Acid; Glutamine; Inositol; Macaca nemestrina; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Pregnancy; Pregnancy Complications, Infectious; RNA, Viral; Ultrasonography, Prenatal; Zika Virus; Zika Virus Infection | 2016 |
Pilot Assessment of Brain Metabolism in Perinatally HIV-Infected Youths Using Accelerated 5D Echo Planar J-Resolved Spectroscopic Imaging.
Topics: Adolescent; AIDS Dementia Complex; Algorithms; Anti-HIV Agents; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Echo-Planar Imaging; Energy Metabolism; Female; Functional Neuroimaging; Glutamic Acid; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Male; Pilot Projects; Young Adult | 2016 |
Similar Progression of Morphological and Metabolic Phenotype in R6/2 Mice with Different CAG Repeats Revealed by In Vivo Magnetic Resonance Imaging and Spectroscopy.
Topics: Animals; Aspartic Acid; Brain; Disease Models, Animal; Disease Progression; Glutamic Acid; Humans; Huntingtin Protein; Huntington Disease; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Trinucleotide Repeats | 2016 |
Caffeine alters glutamate-aspartate transporter function and expression in rat retina.
Topics: Animals; Aspartic Acid; Biological Transport; Caffeine; Central Nervous System; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Neuroglia; Neurons; Rats; Retina; Sodium | 2016 |
A pilot study of hippocampal N-acetyl-aspartate in youth with treatment resistant major depression.
Topics: Adolescent; Aspartic Acid; Brain; Case-Control Studies; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Female; Glutamic Acid; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Pilot Projects; Proton Magnetic Resonance Spectroscopy; Young Adult | 2017 |
Metabolic abnormality in the right dorsolateral prefrontal cortex in patients with obsessive-compulsive disorder: proton magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Brain; Choline; Female; Glutamic Acid; Glutamine; Humans; Inositol; Lactic Acid; Male; Neuroimaging; Obsessive-Compulsive Disorder; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Young Adult | 2017 |
PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.
Topics: Acetylation; Amino Acid Sequence; Antigens, Neoplasm; Aspartic Acid; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Glutamic Acid; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Models, Biological; Models, Molecular; Mutation; Protein Binding; Protein Domains; Transcription Factors; Tumor Suppressor Protein p53 | 2016 |
Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.
Topics: Anhedonia; Animals; Aspartic Acid; Brain Injuries; Central Nervous System Stimulants; Cerebral Cortex; Disease Models, Animal; Exploratory Behavior; Food Preferences; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 3; Glutamic Acid; Grooming; Male; Maze Learning; Methamphetamine; Mice; Mice, Inbred C57BL; Motor Activity | 2017 |
A Metabolomic Approach (
Topics: Alanine; Animals; Aspartic Acid; Glucose; Glutamic Acid; Glutathione; Granulocytes; Immunohistochemistry; Islets of Langerhans Transplantation; Liver; Macrophages; Magnetic Resonance Spectroscopy; Male; Rats | 2016 |
Effects of Glutamate and Aspartate on Serum Antioxidative Enzyme, Sex Hormones, and Genital Inflammation in Boars Challenged with Hydrogen Peroxide.
Topics: Animals; Aspartic Acid; Epididymis; Genitalia, Male; Glutamic Acid; Hydrogen Peroxide; Interleukin-10; Luteinizing Hormone; Male; Malondialdehyde; RNA, Messenger; Testis; Transforming Growth Factor beta1 | 2016 |
Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeet.
Topics: Adenosine Triphosphate; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Connexin 30; Connexin 43; D-Aspartic Acid; Female; Gap Junctions; Glutamic Acid; Hippocampus; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; Mice, Knockout; Signal Transduction; Sodium; Sodium Channel Blockers; Tetrodotoxin | 2017 |
Insight into the mechanism of galactokinase: Role of a critical glutamate residue and helix/coil transitions.
Topics: Adenosine Triphosphate; Aspartic Acid; Catalysis; Catalytic Domain; Galactokinase; Galactose; Galactosemias; Glutamic Acid; Humans; Methionine; Molecular Dynamics Simulation; Protein Conformation; Substrate Specificity | 2017 |
The Outer Pore and Selectivity Filter of TRPA1.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Calcium Channels; CHO Cells; Cricetulus; Glutamic Acid; Humans; Ion Channel Gating; Nerve Tissue Proteins; Permeability; Point Mutation; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2016 |
The role of inversely operating glutamate transporter in the paradoxical analgesia produced by glutamate transporter inhibitors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Amino Acid Transport System X-AG; Analgesics; Animals; Aspartic Acid; Dicarboxylic Acids; Extracellular Space; Formaldehyde; Glutamic Acid; Male; Nociception; Pyrrolidines; Rats; Rats, Sprague-Dawley | 2016 |
Spectroscopic biomarkers of motor cortex developmental plasticity in hemiparetic children after perinatal stroke.
Topics: Adolescent; Analysis of Variance; Aspartic Acid; Cerebral Palsy; Child; Choline; Female; Glutamic Acid; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Motor Activity; Motor Cortex; Oxygen; Proton Magnetic Resonance Spectroscopy; Stroke; Young Adult | 2017 |
Microscopic mechanisms that govern the titration response and pK
Topics: Aspartic Acid; Glutamic Acid; Isoelectric Point; Kinetics; Lysine; Micrococcal Nuclease; Molecular Dynamics Simulation; Mutation; Protein Domains; Protein Folding; Protein Structure, Secondary; Staphylococcus; Structure-Activity Relationship; Thermodynamics | 2017 |
Constitutive regulation of the glutamate/aspartate transporter EAAT1 by Calcium-Calmodulin-Dependent Protein Kinase II.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Excitatory Amino Acid Transporter 1; Female; Glutamic Acid; HEK293 Cells; Humans; Male; Rats; Rats, Sprague-Dawley; Sulfonamides | 2017 |
The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23.
Topics: Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Citric Acid Cycle; Glucose; Glutamic Acid; Glycolysis; Protein Kinase Inhibitors; Rats, Wistar; Tyrphostins | 2017 |
Brain glutamate in anorexia nervosa: a magnetic resonance spectroscopy case control study at 7 Tesla.
Topics: Adolescent; Adult; Anorexia Nervosa; Aspartic Acid; Brain; Case-Control Studies; Creatine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Occipital Lobe; Young Adult | 2017 |
Metabolic differences between cold stored and machine perfused porcine kidneys: A
Topics: Acetic Acid; Animals; Aspartic Acid; Cryopreservation; Energy Metabolism; Fumarates; Glutamic Acid; Hypothermia, Induced; Kidney; Lactic Acid; Magnetic Resonance Imaging; Male; Models, Animal; Organ Preservation; Perfusion; Renal Dialysis; Swine | 2017 |
Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC.
Topics: A549 Cells; Adenosine Triphosphate; Animals; Aspartic Acid; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Death; Cell Proliferation; Cell Survival; Cytosol; Drug Synergism; Fluorouracil; Gene Knockdown Techniques; Glutamic Acid; Glutaminase; Glutamine; Lung Neoplasms; Malates; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; NAD; Oxidation-Reduction; Sulfides; Thiadiazoles; Thymidylate Synthase; Xenograft Model Antitumor Assays | 2016 |
Strong Impact of an Axial Ligand on the Absorption by Chlorophyll a and b Pigments Determined by Gas-Phase Ion Spectroscopy Experiments.
Topics: Acetylcholine; Aspartic Acid; Chlorophyll; Chlorophyll A; Energy Transfer; Formates; Glutamic Acid; Histidine; Kinetics; Ligands; Magnesium; Models, Molecular; Photosystem II Protein Complex; Pisum sativum; Protein Structure, Secondary; Spectrum Analysis; Static Electricity; Thermodynamics | 2016 |
On the appearance of carboxylates in electrostatic potential maps.
Topics: Aspartic Acid; Glutamic Acid; Models, Molecular; Static Electricity | 2017 |
Kinetics of browning and correlations between browning degree and pyrazine compounds in l-ascorbic acid/acidic amino acid model systems.
Topics: Amino Acids; Ascorbic Acid; Aspartic Acid; Glutamic Acid; Kinetics; Maillard Reaction; Models, Biological; Pyrazines | 2017 |
Structure of bovine lactoperoxidase with a partially linked heme moiety at 1.98Å resolution.
Topics: Animals; Aspartic Acid; Binding Sites; Cattle; Crystallography, X-Ray; Glutamic Acid; Heme; Lactoperoxidase; Mammals; Models, Molecular; Peroxidase; Protein Conformation | 2017 |
Influence of Volatile Anesthesia on the Release of Glutamate and other Amino Acids in the Nucleus Accumbens in a Rat Model of Alcohol Withdrawal: A Pilot Study.
Topics: Amino Acids; Anesthesia, Inhalation; Animals; Arginine; Aspartic Acid; Desflurane; Disease Models, Animal; Feeding Behavior; gamma-Aminobutyric Acid; Glutamic Acid; Isoflurane; Male; Microdialysis; Nucleus Accumbens; Pilot Projects; Rats, Wistar; Substance Withdrawal Syndrome; Time Factors; Volatilization | 2017 |
Observation of the side chain O-methylation of glutamic acid or aspartic acid containing model peptides by electrospray ionization-mass spectrometry.
Topics: Amino Acid Sequence; Aspartic Acid; Chromatography, High Pressure Liquid; Esterification; Glutamic Acid; Methylation; Peptides; Spectrometry, Mass, Electrospray Ionization | 2017 |
Changes in cerebral metabolism during ketogenic diet in patients with primary brain tumors:
Topics: Adult; Aged; Antineoplastic Agents, Immunological; Aspartic Acid; Bevacizumab; Brain Neoplasms; Cerebral Cortex; Diet, Ketogenic; Female; Glucose; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nutrition Assessment; Protons; Severity of Illness Index | 2017 |
Negative Association Between MR-Spectroscopic Glutamate Markers and Gray Matter Volume After Alcohol Withdrawal in the Hippocampus: A Translational Study in Humans and Rats.
Topics: Adult; Alcohol Abstinence; Alcoholism; Animals; Aspartic Acid; Biomarkers; Female; Glutamic Acid; Gray Matter; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Rats; Rats, Wistar; Species Specificity; Substance Withdrawal Syndrome; Translational Research, Biomedical | 2017 |
Improvement of the ammonia assimilation for enhancing L-arginine production of Corynebacterium crenatum.
Topics: Ammonia; Arginine; Aspartic Acid; Batch Cell Culture Techniques; Corynebacterium; Culture Media; Escherichia coli; Escherichia coli Proteins; Fermentation; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Industrial Microbiology; Metabolic Engineering | 2017 |
Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Biological Transport; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Coculture Techniques; Endothelial Cells; Excitatory Amino Acid Transporter 1; Glutamic Acid; Kinetics; Lactic Acid; Rats | 2017 |
How the extra methylene group affects the ligation properties of Glu vs. Asp and Gln vs. Asn amino acids: a DFT/PCM study.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Computer Simulation; Glutamic Acid; Glutamine; Ligands; Methane; Models, Chemical; Protein Binding; Proteins; Thermodynamics | 2017 |
Multimodal MRI Imaging of Apoptosis-Triggered Microstructural Alterations in the Postnatal Cerebral Cortex.
Topics: Animals; Animals, Newborn; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Apoptosis; Aspartic Acid; Calcium-Binding Proteins; Cell Death; Cerebral Cortex; Dendrites; Diphtheria Toxin; Embryo, Mammalian; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Luminescent Proteins; Microfilament Proteins; Neurons; Phosphopyruvate Hydratase; Rats; Rats, Wistar | 2018 |
β-N-Methylamino-L-alanine (BMAA) perturbs alanine, aspartate and glutamate metabolism pathways in human neuroblastoma cells as determined by metabolic profiling.
Topics: Alanine; Amino Acids, Diamino; Aspartic Acid; Cell Differentiation; Cell Line, Tumor; Cyanobacteria Toxins; Cytotoxins; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Metabolic Networks and Pathways; Metabolome; Neurons; Principal Component Analysis; Taurine; Tretinoin | 2017 |
Simultaneous determination of metabolite concentrations, T
Topics: Adult; Algorithms; Aspartic Acid; Brain; Choline; Creatine; Female; Frontal Lobe; Glutamic Acid; Gray Matter; Healthy Volunteers; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Male; Monte Carlo Method; Phantoms, Imaging; White Matter; Young Adult | 2017 |
Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: a longitudinal neuroimaging study.
Topics: Aged; Aspartic Acid; Brain; Case-Control Studies; Depressive Disorder, Treatment-Resistant; Electroconvulsive Therapy; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Hippocampus; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Middle Aged; Organ Size; Proton Magnetic Resonance Spectroscopy; Temporal Lobe | 2017 |
Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue.
Topics: Adult; Aging; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Depression; Disability Evaluation; Fatigue; Female; Glutamic Acid; Humans; Hypothalamus; Inositol; Male; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Proton Magnetic Resonance Spectroscopy; Psychiatric Status Rating Scales; Severity of Illness Index | 2017 |
MR Spectroscopy Findings in Retired Professional Rugby League Players.
Topics: Adult; Aspartic Acid; Athletes; Brain; Brain Chemistry; Brain Concussion; Case-Control Studies; Choline; Football; Glutamic Acid; Glutathione; Humans; Inositol; Magnetic Resonance Spectroscopy; Neuropsychological Tests; Retirement | 2017 |
Hippocampus Glutamate and N-Acetyl Aspartate Markers of Excitotoxic Neuronal Compromise in Posttraumatic Stress Disorder.
Topics: Adult; Aspartic Acid; Biomarkers; Case-Control Studies; Female; Glutamic Acid; Hippocampus; Humans; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Stress Disorders, Post-Traumatic; Wounds and Injuries; Young Adult | 2017 |
Predicting Electrophoretic Mobility of Tryptic Peptides for High-Throughput CZE-MS Analysis.
Topics: Aspartic Acid; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Electrophoresis, Capillary; Electrophoretic Mobility Shift Assay; Glutamic Acid; HeLa Cells; High-Throughput Screening Assays; Humans; Mass Spectrometry; Models, Chemical; Peptides; Trypsin | 2017 |
Arctic ground squirrel hippocampus tolerates oxygen glucose deprivation independent of hibernation season even when not hibernating and after ATP depletion, acidosis, and glutamate efflux.
Topics: Acidosis; Adenosine Triphosphate; Animals; Aspartic Acid; Cell Death; Glucose; Glutamic Acid; Hibernation; Hippocampus; Hypoxia, Brain; In Vitro Techniques; L-Lactate Dehydrogenase; Rats; Rats, Sprague-Dawley; Sciuridae; Seasons; Temperature | 2017 |
Ceftriaxone-mediated upregulation of the glutamate transporter GLT-1 contrasts neurotoxicity evoked by kainate in rat organotypic spinal cord cultures.
Topics: Animals; Anti-Bacterial Agents; Aspartic Acid; Astrocytes; Ceftriaxone; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Kainic Acid; Motor Neurons; Neurons; Neuroprotective Agents; Organ Culture Techniques; Rats, Wistar; Spinal Cord; Up-Regulation | 2017 |
Proton Magnetic Resonance Spectroscopy Indicates Preserved Cerebral Biochemical Composition in Duchenne Muscular Dystrophy Patients.
Topics: Adolescent; Aquaporin 4; Aspartic Acid; Brain; Case-Control Studies; Cerebellum; Child; Choline; Creatine; Frontal Lobe; Glutamic Acid; Glutamine; Hippocampus; Humans; Inositol; Male; Muscular Dystrophy, Duchenne; Proton Magnetic Resonance Spectroscopy; Receptors, GABA-A | 2017 |
Neurochemical responses to chromatic and achromatic stimuli in the human visual cortex.
Topics: Aspartic Acid; Brain Chemistry; Color; Electron Transport Complex IV; Energy Metabolism; Evoked Potentials, Visual; Glucose; Glutamic Acid; Healthy Volunteers; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neurons; Oxidation-Reduction; Photic Stimulation; Visual Cortex | 2018 |
Extracellular Glutamate in the Nucleus Accumbens Is Nanomolar in Both Synaptic and Non-synaptic Compartments.
Topics: Animals; Aspartic Acid; Calcium Signaling; Cell Compartmentation; Extracellular Space; Female; Glutamic Acid; Male; N-Methylaspartate; Neurons; Nucleus Accumbens; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses | 2017 |
Methanol extract of Nigella sativa seed induces changes in the levels of neurotransmitter amino acids in male rat brain regions.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Methanol; Neurotransmitter Agents; Nigella sativa; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Wistar; Seeds; Solvents | 2017 |
Control of Glutamate Transport by Extracellular Potassium: Basis for a Negative Feedback on Synaptic Transmission.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Cerebral Cortex; Excitatory Amino Acid Antagonists; Extracellular Fluid; GABA-A Receptor Antagonists; Glutamic Acid; HEK293 Cells; Humans; Membrane Potentials; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Potassium; Synaptic Transmission; Xanthenes | 2017 |
Retrospective correction of frequency drift in spectral editing: The GABA editing example.
Topics: Aspartic Acid; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Metabolome; Retrospective Studies; White Matter | 2017 |
Maturational decrease of glutamate in the human cerebral cortex from childhood to young adulthood: a
Topics: Adolescent; Adolescent Development; Adult; Age Factors; Aspartic Acid; Biomarkers; Cerebral Cortex; Child; Child Development; Child, Preschool; Creatine; Down-Regulation; Female; Glutamic Acid; Healthy Volunteers; Humans; Male; Proton Magnetic Resonance Spectroscopy; Young Adult | 2017 |
Chiral acidic amino acids induce chiral hierarchical structure in calcium carbonate.
Topics: Amino Acids, Acidic; Aspartic Acid; Calcium Carbonate; Glutamic Acid; Microscopy, Electron; Nanostructures; Stereoisomerism; X-Ray Diffraction | 2017 |
High-Affinity Copolymers Inhibit Digestive Enzymes by Surface Recognition.
Topics: Alanine; Aspartic Acid; Benzamidines; Catalytic Domain; Diphosphonates; Enzyme Assays; Enzyme Inhibitors; Glutamic Acid; Humans; Kinetics; Pancreatic Elastase; Polymerization; Polymers; Protein Binding; Serine Proteases | 2017 |
Transport of BMAA into Neurons and Astrocytes by System x
Topics: Amino Acid Transport Systems; Amino Acids, Diamino; Animals; Aspartic Acid; Astrocytes; Carbon Isotopes; Cells, Cultured; Cerebral Cortex; Cyanobacteria Toxins; Cysteine; Embryo, Mammalian; Female; Glutamic Acid; Glutathione; Mice; Neurons; Neurotransmitter Uptake Inhibitors; Pregnancy; Sulfasalazine; Time Factors | 2018 |
Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using
Topics: Aged; Aged, 80 and over; Aging; Ascorbic Acid; Aspartic Acid; Brain Chemistry; Creatine; Dipeptides; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Phosphocreatine; Tritium; Young Adult | 2017 |
Effects of experimental traumatic brain injury and impaired glutamate transport on cortical spreading depression.
Topics: Animals; Aspartic Acid; Astrocytes; Biological Transport; Brain Injuries, Traumatic; Cortical Spreading Depression; Electrophysiological Phenomena; Glucose Transporter Type 1; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; Rats; Rats, Sprague-Dawley; Sodium Channels; Voltage-Sensitive Dye Imaging | 2017 |
Glutamatergic and neural dysfunction in postpartum depression using magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Depression, Postpartum; Dipeptides; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy | 2017 |
Inhibition of glutamate release by cilnidipine in rat cerebrocortical nerve terminals (synaptosomes).
Topics: 4-Aminopyridine; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Cell Membrane; Cerebral Cortex; Dihydropyridines; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Isoquinolines; Macrolides; Male; Potassium Channel Blockers; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Sulfonamides; Synaptosomes | 2017 |
Ultra high-field (7tesla) magnetic resonance spectroscopy in Amyotrophic Lateral Sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Motor Neurons | 2017 |
Amino acid and acetylcholine chemistry in the central auditory system of young, middle-aged and old rats.
Topics: Acetylcholine; Age Factors; Aging; Amino Acids; Animals; Aspartic Acid; Auditory Pathways; Brain; Choline O-Acetyltransferase; Crosses, Genetic; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hearing; Male; Presbycusis; Rats, Inbred BN; Rats, Inbred F344 | 2017 |
pH-Dependent absorption spectrum of a protein: a minimal electrostatic model of Anabaena sensory rhodopsin.
Topics: Anabaena; Aspartic Acid; Bacterial Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Models, Chemical; Sensory Rhodopsins; Spectrophotometry | 2017 |
Assessing the Psychedelic "After-Glow" in Ayahuasca Users: Post-Acute Neurometabolic and Functional Connectivity Changes Are Associated with Enhanced Mindfulness Capacities.
Topics: Adult; Aspartic Acid; Banisteriopsis; Brain Mapping; Cerebral Cortex; Female; Follow-Up Studies; Glutamic Acid; Hallucinogens; Healthy Volunteers; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mindfulness; Surveys and Questionnaires; Time Factors | 2017 |
Active-Site pKa Determination for Photoactive Yellow Protein Rationalizes Slow Ground-State Recovery.
Topics: Aspartic Acid; Bacterial Proteins; Glutamic Acid; Halorhodospira halophila; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Photoreceptors, Microbial; Protons | 2017 |
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.
Topics: Amino Acids; Animals; Aspartic Acid; Bacterial Proteins; Glutamic Acid; Homeostasis; Macrophages; Metabolomics; Mice; Mycobacterium tuberculosis; Phosphorylation; Protein Serine-Threonine Kinases; Tuberculosis; Virulence | 2017 |
Effect of aspartic acid and glutamate on metabolism and acid stress resistance of Acetobacter pasteurianus.
Topics: Acetic Acid; Acetobacter; Aspartic Acid; Fatty Acids; Fermentation; Glutamic Acid; Glutathione; NADP; Oxidation-Reduction; Pentose Phosphate Pathway; Proteomics; Stress, Physiological | 2017 |
Analysis of a dual domain phosphoglycosyl transferase reveals a ping-pong mechanism with a covalent enzyme intermediate.
Topics: Anti-Bacterial Agents; Aspartic Acid; Bacterial Proteins; Campylobacter; Catalytic Domain; Glutamic Acid; Kinetics; Luminescence; Models, Chemical; Peptidoglycan; Substrate Specificity; Sugars; Transferases | 2017 |
Topics: Acetylcholine; Alkynes; Allosteric Regulation; Amino Acid Substitution; Anti-HIV Agents; Aspartic Acid; Benzoxazines; Binding Sites; Biocatalysis; Cholesterol 24-Hydroxylase; Cyclopropanes; Deuterium Exchange Measurement; Enzyme Activation; gamma-Aminobutyric Acid; Glutamic Acid; Ligands; Models, Molecular; Molecular Docking Simulation; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Peptide Fragments; Protein Conformation; Recombinant Fusion Proteins | 2017 |
Longitudinal increases of brain metabolite levels in 5-10 year old children.
Topics: Aspartic Acid; Brain; Child; Child, Preschool; Creatine; Female; Glutamic Acid; HIV Infections; Humans; Magnetic Resonance Spectroscopy; Male | 2017 |
Molecular determinants of acidic pH-dependent transport of human equilibrative nucleoside transporter 3.
Topics: Aspartic Acid; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Mutation; Nucleoside Transport Proteins | 2017 |
Pre-therapy Neural State of Bilateral Motor and Premotor Cortices Predicts Therapy Gain After Subcortical Stroke: A Pilot Study.
Topics: Aspartic Acid; Biomarkers; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Movement Disorders; Outcome Assessment, Health Care; Pilot Projects; Stroke Rehabilitation | 2018 |
Copper II - polar amino acid complexes: toxicity to bacteria and larvae of Aedes aegypti.
Topics: Aedes; Animals; Aspartic Acid; Copper; Escherichia coli; Glutamic Acid; Larva; Lethal Dose 50; Staphylococcus aureus; Toxicity Tests | 2017 |
Aripiprazole and Riluzole treatment alters behavior and neurometabolites in young ADHD rats: a longitudinal
Topics: Animals; Antipsychotic Agents; Aripiprazole; Aspartic Acid; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Brain; Disease Models, Animal; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Motor Activity; Neuroprotective Agents; Rats; Rats, Inbred WKY; Riluzole | 2017 |
A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus.
Topics: Asparagine; Aspartate Aminotransferases; Aspartic Acid; Cell Proliferation; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Herpesvirus 8, Human; Humans; Metabolic Networks and Pathways; Neoplasms; Nitrogen; Nucleotides | 2017 |
Quantifying absolute glutamate concentrations in nucleus accumbens of prescription opioid addicts by using
Topics: Adult; Analgesics, Opioid; Aspartic Acid; Behavioral Symptoms; Creatine; Female; Glutamic Acid; Humans; Male; Middle Aged; Nucleus Accumbens; Opioid-Related Disorders; Proton Magnetic Resonance Spectroscopy; Reproducibility of Results | 2017 |
NSCs promote hippocampal neurogenesis, metabolic changes and synaptogenesis in APP/PS1 transgenic mice.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Cognition Disorders; Creatine; Disease Models, Animal; Glutamic Acid; Hippocampus; Male; Mice, Inbred C57BL; Mice, Transgenic; Neural Stem Cells; Neurogenesis; Synapses | 2017 |
Quantitative MR spectroscopic imaging in metachromatic leukodystrophy: value for prognosis and treatment.
Topics: Adolescent; Adult; Aspartic Acid; Child; Child, Preschool; Creatine; Female; Glutamic Acid; Humans; Leukodystrophy, Metachromatic; Magnetic Resonance Spectroscopy; Male; Prognosis; Retrospective Studies; White Matter | 2018 |
Cortical functional hyperconnectivity in a mouse model of depression and selective network effects of ketamine.
Topics: Animals; Antidepressive Agents; Aspartic Acid; Behavior, Animal; Cerebral Cortex; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Ketamine; Male; Mice; Mice, Transgenic; Neural Pathways; Neurons; Social Behavior; Vesicular Glutamate Transport Proteins; Voltage-Sensitive Dye Imaging | 2017 |
Hippocampal metabolism and prefrontal brain structure: A combined 1H-MR spectroscopy, neuropsychological, and voxel-based morphometry (VBM) study.
Topics: Adult; Aspartic Acid; Complex Mixtures; Female; Functional Laterality; Glutamic Acid; Gray Matter; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Mental Processes; Middle Aged; Neuropsychological Tests; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Young Adult | 2017 |
Astrocyte-Mediated Neuronal Synchronization Properties Revealed by False Gliotransmitter Release.
Topics: Animals; Aspartic Acid; Astrocytes; Brain Chemistry; CA1 Region, Hippocampal; Female; Glutamic Acid; In Vitro Techniques; Male; Neuroglia; Neurons; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Thalamus | 2017 |
An Objective Short Sleep Insomnia Disorder Subtype Is Associated With Reduced Brain Metabolite Concentrations In Vivo: A Preliminary Magnetic Resonance Spectroscopy Assessment.
Topics: Adult; Aspartic Acid; Brain; Case-Control Studies; Creatine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Polysomnography; Prefrontal Cortex; Sleep; Sleep Initiation and Maintenance Disorders; Time Factors; Young Adult | 2017 |
The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization.
Topics: Animals; Aspartic Acid; Astrocytes; Brain Diseases; Cell Size; Computational Biology; Electrophysiological Phenomena; Glutamic Acid; Homeostasis; In Vitro Techniques; Ion Channels; Male; Membrane Potentials; Models, Neurological; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Visual Cortex | 2017 |
Effects of three major amino acids found in Japanese broth on glucose metabolism and gastric emptying.
Topics: Adult; Amino Acids; Animals; Aspartic Acid; Blood Glucose; C-Peptide; Cross-Over Studies; Diet; Female; Fishes; Food, Preserved; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glutamic Acid; Histidine; Humans; Insulin; Japan; Kelp; Male; Oryza | 2018 |
Interaction of Excitatory Amino Acid Transporters 1 - 3 (EAAT1, EAAT2, EAAT3) with N-Carbamoylglutamate and N-Acetylglutamate.
Topics: Administration, Oral; Animals; Aspartic Acid; Dicarboxylic Acid Transporters; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamates; Glutamic Acid; Humans; Organic Anion Transporters, Sodium-Dependent; Symporters; Xenopus laevis | 2017 |
Endogenous glutamate within the prelimbic and infralimbic cortices regulates the incubation of cocaine-seeking in rats.
Topics: Amino Acids; Anesthetics, Local; Animals; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Drug-Seeking Behavior; Excitatory Amino Acid Agents; Glutamic Acid; Male; Microdialysis; Microinjections; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration | 2018 |
Chiral Measurement of Aspartate and Glutamate in Single Neurons by Large-Volume Sample Stacking Capillary Electrophoresis.
Topics: Animals; Aplysia; Aspartic Acid; Central Nervous System; Electrophoresis, Capillary; Glutamic Acid | 2017 |
[Effect of Acupuncture at "Taichong"(LR 3) and "Neiguan"(PC 6) on Blood Pressure and Contents of Aspartic Acid and Glutamic Acid in the Rostral Ventrolateral Medulla in Spontaneous Hypertension Rats].
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Aspartic Acid; Blood Pressure; Disease Models, Animal; Glutamic Acid; Humans; Hypertension; Male; Medulla Oblongata; Rats; Rats, Inbred SHR; Rats, Wistar | 2017 |
Improved resolution of glutamate, glutamine and γ-aminobutyric acid with optimized point-resolved spectroscopy sequence timings for their simultaneous quantification at 9.4 T.
Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Magnetic Resonance Spectroscopy; Phantoms, Imaging; Rats | 2018 |
Effect of amino acid mutations on intra-dimer tubulin-tubulin binding strength of microtubules.
Topics: Arginine; Aspartic Acid; Binding Sites; Computer Simulation; Dimerization; Glutamic Acid; Humans; Lysine; Microtubules; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Static Electricity; Stress, Mechanical; Tensile Strength; Tubulin | 2017 |
Prefrontal and Striatal Gamma-Aminobutyric Acid Levels and the Effect of Antipsychotic Treatment in First-Episode Psychosis Patients.
Topics: Adolescent; Adult; Antipsychotic Agents; Aspartic Acid; Corpus Striatum; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Imaging; Male; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Psychiatric Status Rating Scales; Psychotic Disorders; Risperidone; Young Adult | 2018 |
Recognition dynamics of trinuclear copper cluster and associated histidine residues through conserved or semi-conserved water molecules in human Ceruloplasmin: The involvement of aspartic and glutamic acid gates.
Topics: Aspartic Acid; Ceruloplasmin; Copper; Glutamic Acid; Histidine; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Conformation; Oxidoreductases; Structure-Activity Relationship; Water | 2018 |
The administration of hydrogen sulphide prior to ischemic reperfusion has neuroprotective effects in an acute stroke model.
Topics: Animals; Apoptosis; Aspartic Acid; Brain Ischemia; Disease Models, Animal; Glutamic Acid; Humans; Hydrogen Sulfide; Neuroprotective Agents; Rats; Reperfusion Injury; Stroke; Taurine | 2017 |
Striatal structure and its association with N-Acetylaspartate and glutamate in autism spectrum disorder and obsessive compulsive disorder.
Topics: Adolescent; Aspartic Acid; Autism Spectrum Disorder; Child; Corpus Striatum; Female; Functional Laterality; Glutamic Acid; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Obsessive-Compulsive Disorder; Organ Size; Proton Magnetic Resonance Spectroscopy | 2018 |
Associations of neurofunctional, morphometric and metabolic abnormalities with clinical symptom severity and recognition deficit in obsessive-compulsive disorder.
Topics: Adult; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Creatine; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Male; Memory, Short-Term; Obsessive-Compulsive Disorder; Proton Magnetic Resonance Spectroscopy | 2018 |
Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and Glutamate + Glutamine Levels.
Topics: Adolescent; Aspartic Acid; Autism Spectrum Disorder; Biomarkers; Child; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Prefrontal Cortex | 2018 |
Neurochemical changes in the medial wall of the brain in chronic migraine.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Brain Mapping; Chronic Disease; Correlation of Data; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Male; Migraine Disorders; Severity of Illness Index; Statistics, Nonparametric; Taiwan; Young Adult | 2018 |
Copper chloride dose-dependently alters spatial learning and memory, and glutamate levels, in the hippocampus of rats.
Topics: Animals; Aspartic Acid; Brain Chemistry; Copper; Dipeptides; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Maze Learning; Memory; Phosphocreatine; Proton Magnetic Resonance Spectroscopy; Rats; Rats, Sprague-Dawley | 2018 |
Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus.
Topics: Adenylyl Cyclases; Animals; Aspartic Acid; Cerebral Cortex; Cyclic AMP; Dideoxyadenosine; Evoked Potentials; Exenatide; gamma-Aminobutyric Acid; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Peptides; Presynaptic Terminals; Receptors, Presynaptic; Synaptosomes; Venoms | 2018 |
A molecular mechanics study on GA codon box translation.
Topics: Anticodon; Aspartic Acid; Base Pairing; Base Sequence; Codon; Genetic Code; Glutamic Acid; Hydrogen Bonding; Models, Genetic; Models, Molecular; Nucleic Acid Conformation | 2018 |
7T Proton Magnetic Resonance Spectroscopy of the Anterior Cingulate Cortex in First-Episode Schizophrenia.
Topics: Adult; Aspartic Acid; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Humans; Male; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Schizophrenia; Young Adult | 2019 |
Maternal overnutrition leads to cognitive and neurochemical abnormalities in C57BL/6 mice.
Topics: Animals; Aspartic Acid; Avoidance Learning; Brain Chemistry; Cognitive Dysfunction; Diet, High-Fat; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Maternal Nutritional Physiological Phenomena; Memory, Short-Term; Mice, Inbred C57BL; Overnutrition; Prepulse Inhibition; Taurine | 2019 |
Striatal neurometabolite levels in patients with schizophrenia undergoing long-term antipsychotic treatment: A proton magnetic resonance spectroscopy and reliability study.
Topics: Adult; Antipsychotic Agents; Aspartic Acid; Case-Control Studies; Choline; Corpus Striatum; Creatine; Female; Glutamic Acid; Glutamine; Humans; Inositol; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Reproducibility of Results; Schizophrenia | 2018 |
In vivo characterization of brain metabolism by
Topics: Adaptor Proteins, Signal Transducing; Animals; Aspartic Acid; Brain; Brain Neoplasms; Cell Line, Tumor; Fluorodeoxyglucose F18; gamma-Aminobutyric Acid; Glioma; Glucose; Glutamic Acid; Humans; Male; Mice; Neoplasm Transplantation; Oxidation-Reduction; Positron-Emission Tomography; Proton Magnetic Resonance Spectroscopy; Repressor Proteins | 2018 |
Distinction of the GABA 2.29 ppm resonance using triple refocusing at 3 T in vivo.
Topics: Adult; Aspartic Acid; Brain; Brain Chemistry; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Phantoms, Imaging; Young Adult | 2018 |
The impact of acute and short-term methamphetamine abstinence on brain metabolites: A proton magnetic resonance spectroscopy chemical shift imaging study.
Topics: Adolescent; Adult; Amphetamine-Related Disorders; Aspartic Acid; Brain; Choline; Creatine; Dipeptides; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Male; Methamphetamine; Neurons; Proton Magnetic Resonance Spectroscopy; Young Adult | 2018 |
[Protective effects of Ginkgo Terpene Lactones Meglumine Injection on focal cerebral ischemia in rats].
Topics: Animals; Aspartic Acid; Brain Ischemia; Calcium; Creatine Kinase, BB Form; Ginkgo biloba; Glutamic Acid; Glutathione; L-Lactate Dehydrogenase; Lactic Acid; Lactones; Male; Malondialdehyde; Meglumine; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Terpenes | 2017 |
Photocycle of Sensory Rhodopsin II from Halobacterium salinarum (HsSRII): Mutation of D103 Accelerates M Decay and Changes the Decay Pathway of a 13-cis O-like Species.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Cold Temperature; Glutamic Acid; Halobacterium salinarum; Halorhodopsins; Hydrogen Bonding; Light; Mutation; Photochemical Processes; Photolysis; Sensory Rhodopsins; Spectroscopy, Fourier Transform Infrared | 2018 |
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Creatine; Energy Metabolism; Female; Flame Retardants; Glutamic Acid; Hippocampus; Magnetic Resonance Spectroscopy; Metabolomics; Organophosphates; Rats; Rats, Sprague-Dawley | 2018 |
Optical measurement of glutamate in slice preparations of the mouse retina.
Topics: Animals; Aspartic Acid; Cadmium Compounds; Calcium Channel Blockers; Enzyme-Linked Immunosorbent Assay; GABA Antagonists; Glutamic Acid; Mice; Mice, Inbred C57BL; Picrotoxin; Potassium; Retina; Retinal Ganglion Cells; Spectrometry, Fluorescence; Strychnine; Synapses; Vesicular Glutamate Transport Proteins | 2018 |
XPlex: An Effective, Multiplex Cross-Linking Chemistry for Acidic Residues.
Topics: Algorithms; Aspartic Acid; Computational Biology; Cross-Linking Reagents; Esters; Glutamic Acid; Lysine; Mass Spectrometry; Proteins; Serine; Succinimides; Temperature | 2018 |
Neurochemical abnormalities in premanifest and early spinocerebellar ataxias.
Topics: Activities of Daily Living; Adult; Aged; Aspartic Acid; Ataxins; Brain; Brain Diseases, Metabolic; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Disease Progression; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Spinocerebellar Ataxias; Young Adult | 2018 |
Cysteine Scanning Mutagenesis of TM4b-4c Loop of Glutamate Transporter EAAT1 Reveals Three Conformationally Sensitive Residues.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Cysteine; Excitatory Amino Acid Transporter 1; Glutamic Acid; HeLa Cells; Humans; Mutagenesis; Potassium; Protein Structure, Secondary; Rats; Structure-Activity Relationship; Tetraspanins | 2018 |
Effects of nitrogen combined with zinc application on glutamate, glutamine, aspartate and asparagine accumulation in two winter wheat cultivars.
Topics: Asparagine; Aspartic Acid; Glutamic Acid; Glutamine; Nitrogen; Triticum; Zinc | 2018 |
J-difference-edited MRS measures of γ-aminobutyric acid before and after acute caffeine administration.
Topics: Adult; Algorithms; Aspartic Acid; Brain Mapping; Caffeine; Central Nervous System Stimulants; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Healthy Volunteers; Humans; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Spectroscopy; Male; Neurotransmitter Agents; Normal Distribution; Young Adult | 2018 |
Characterisation of a putative glutamate 5-kinase from Leishmania donovani.
Topics: Amino Acid Sequence; Aspartic Acid; Biocatalysis; Cloning, Molecular; Escherichia coli; Gene Expression; Genetic Complementation Test; Genetic Vectors; Glutamic Acid; Humans; Kinetics; Leishmania donovani; Phosphotransferases (Carboxyl Group Acceptor); Phylogeny; Proline; Protein Binding; Protein Interaction Domains and Motifs; Protein Multimerization; Protozoan Proteins; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Thermodynamics | 2018 |
Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain.
Topics: Aspartic Acid; Glutamic Acid; Heat-Shock Proteins; Models, Molecular; Mutation, Missense; Phosphorylation; Protein Folding; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2018 |
N-Acetyl and Glutamatergic Neurometabolites in Perisylvian Brain Regions of Methamphetamine Users.
Topics: Adolescent; Adult; Amphetamine-Related Disorders; Anxiety; Aspartic Acid; Central Nervous System Stimulants; Cerebral Cortex; Cross-Sectional Studies; Depression; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methamphetamine; Middle Aged; Young Adult | 2019 |
Quantification of Glutamate and Aspartate by Ultra-High Performance Liquid Chromatography.
Topics: Aspartic Acid; Chromatography, High Pressure Liquid; Glutamic Acid; Indicators and Reagents; Reproducibility of Results; Solanum lycopersicum; Spectrophotometry, Ultraviolet | 2018 |
Changes in Brain Metabolite Concentrations after Neonatal Hypoxic-ischemic Encephalopathy.
Topics: Aspartic Acid; Creatine; Female; Glutamic Acid; Glutamine; Gray Matter; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Patient Outcome Assessment; Predictive Value of Tests; Retrospective Studies | 2018 |
The neurotoxin diethyl dithiophosphate impairs glutamate transport in cultured Bergmann glia cells.
Topics: Animals; Aspartic Acid; Astrocytes; Chickens; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Neuroglia; Neurons; Neurotoxins; Neurotransmitter Agents; Receptors, Glutamate; Synapses | 2019 |
Pre- and Postsynaptic Effects of Glutamate in the Frog Labyrinth.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Anura; Aspartic Acid; Ear, Inner; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hair Cells, Auditory; Patch-Clamp Techniques; Receptors, Ionotropic Glutamate; Receptors, Metabotropic Glutamate; Synapses; Xanthenes | 2018 |
Glutathione and glutamate in schizophrenia: a 7T MRS study.
Topics: Adult; Aspartic Acid; Brain; Cerebral Cortex; Female; Glutamic Acid; Glutamine; Glutathione; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Proton Magnetic Resonance Spectroscopy; Schizophrenia | 2020 |
Swift Acid Rain Sensing by Synergistic Rhizospheric Bioelectrochemical Responses.
Topics: Acid Rain; Alanine; Aspartic Acid; Electrochemical Techniques; Environmental Monitoring; Galactose; Glucose; Glutamic Acid; Oryza; Photosynthesis; Plant Leaves; Plant Roots; Rhizosphere | 2018 |
Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice.
Topics: Animals; Aspartic Acid; Blotting, Western; Brain-Derived Neurotrophic Factor; Electroacupuncture; Exercise Test; Glutamic Acid; Hippocampus; Inositol; Learning; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Maze Learning; Membrane Glycoproteins; Memory; Mice; Mice, Transgenic; Models, Animal; Protein-Tyrosine Kinases; Random Allocation | 2018 |
Aspartate deficiency limits peptidoglycan synthesis and sensitizes cells to antibiotics targeting cell wall synthesis in Bacillus subtilis.
Topics: Anti-Bacterial Agents; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Bacillus subtilis; Cell Wall; Diaminopimelic Acid; Glutamic Acid; Peptidoglycan | 2018 |
Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross-linking between diethoxyphospho-Lys and Glu or Asp: Implications for neurotoxicity.
Topics: Acetylcholinesterase; Amino Acid Sequence; Animals; Aspartic Acid; Chlorpyrifos; Cholinesterase Inhibitors; Cross-Linking Reagents; Crystallography, X-Ray; Glutamic Acid; Lysine; Models, Molecular; Neurotoxicity Syndromes; Peptides; Phosphorylation; Protein Aggregates; Swine; Tubulin; Tyrosine | 2018 |
Hippocampal metabolites in asthma and their implications for cognitive function.
Topics: Adolescent; Adult; Aspartic Acid; Asthma; Cognition; Cognitive Dysfunction; Creatine; Female; Glutamic Acid; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Young Adult | 2018 |
Members of the GH3 Family of Proteins Conjugate 2,4-D and Dicamba with Aspartate and Glutamate.
Topics: 2,4-Dichlorophenoxyacetic Acid; Arabidopsis; Arabidopsis Proteins; Aspartic Acid; Benzoates; Cyclopentanes; Dicamba; Glutamic Acid; Glycine max; Indoleacetic Acids; Oxylipins; Phylogeny; Plant Growth Regulators; Plant Proteins; Substrate Specificity | 2018 |
Metabolic profiles of cysteine, methionine, glutamate, glutamine, arginine, aspartate, asparagine, alanine and glutathione in Streptococcus thermophilus during pH-controlled batch fermentations.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Culture Media; Cysteine; Fermentation; Glutamic Acid; Glutamine; Glutathione; Hydrogen-Ion Concentration; Metabolic Networks and Pathways; Metabolome; Methionine; Nitrogen; Streptococcus thermophilus | 2018 |
Increased glutamate and deep brain atrophy can predict the severity of multiple sclerosis.
Topics: Adult; Aspartic Acid; Atrophy; Disease Progression; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Multiple Sclerosis; Predictive Value of Tests; Severity of Illness Index; Thalamus; Young Adult | 2019 |
Discovery, Structural and Biochemical Studies of a rare Glu/Asp Specific M1 Class Aminopeptidase from Legionella pneumophila.
Topics: Amino Acid Sequence; Aspartic Acid; Catalysis; Catalytic Domain; CD13 Antigens; Glutamic Acid; Humans; Hydrolysis; Legionella pneumophila; Protein Conformation; Substrate Specificity | 2018 |
A post-ingestive amino acid sensor promotes food consumption in Drosophila.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Calcium; Drosophila; Drosophila Proteins; Eating; Feeding Behavior; Female; Glutamic Acid; Insect Hormones; Male; Neurons; Nutritional Status; RNA Interference; RNA, Small Interfering; Transcriptome | 2018 |
Metabolic Alterations Within the Primary Visual Cortex in Early Open-angle Glaucoma Patients: A Proton Magnetic Resonance Spectroscopy Study.
Topics: Adult; Aged; Aspartic Acid; Choline; Creatine; Female; Glaucoma, Open-Angle; Glutamic Acid; Glutamine; Humans; Inositol; Intraocular Pressure; Magnetic Resonance Imaging; Male; Middle Aged; Neuronal Plasticity; Proton Magnetic Resonance Spectroscopy; Visual Cortex | 2018 |
One Step up the Ladder of Prebiotic Complexity: Formation of Nonrandom Linear Polypeptides from Binary Systems of Amino Acids on Silica.
Topics: Amino Acids; Aspartic Acid; Glutamic Acid; Leucine; Peptides; Polymerization; Prebiotics; Silicon Dioxide; Spectrometry, Mass, Electrospray Ionization; Thermogravimetry; Valine | 2019 |
Neurometabolic abnormalities in the associative striatum in antipsychotic-naïve first episode psychosis patients.
Topics: Adolescent; Adult; Aspartic Acid; Biomarkers; Case-Control Studies; Choline; Corpus Striatum; Disease Progression; Dopamine; Female; Glutamic Acid; Humans; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Schizophrenia; Young Adult | 2018 |
Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy.
Topics: Adaptor Proteins, Signal Transducing; Animals; Aspartic Acid; Breast Neoplasms; Cancer-Associated Fibroblasts; Carcinoma; Cell Line; Extracellular Matrix; Female; Glutamic Acid; Head and Neck Neoplasms; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Trans-Activators; Transcription Factors; Transcriptional Coactivator with PDZ-Binding Motif Proteins; YAP-Signaling Proteins | 2019 |
Histone Tail Sequences Balance Their Role in Genetic Regulation and the Need To Protect DNA against Destruction in Nucleosome Core Particles Containing Abasic Sites.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; DNA; DNA Cleavage; Glutamic Acid; Histidine; Histones; Humans; Lysine; Mice; Mutation; Nucleosomes; Saccharomyces cerevisiae; Xenopus laevis | 2019 |
Epigenetic upregulation and functional role of the mitochondrial aspartate/glutamate carrier isoform 1 in hepatocellular carcinoma.
Topics: Amino Acid Transport Systems, Acidic; Antiporters; Aspartic Acid; Brain; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Glutamic Acid; Heart; Hep G2 Cells; Humans; Liver Neoplasms; Mitochondrial Membrane Transport Proteins; Muscle, Skeletal; Protein Isoforms; Up-Regulation | 2019 |
A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice.
Topics: Amino Acid Transport System X-AG; Animals; Anti-Anxiety Agents; Anxiety; Aspartic Acid; Drug Interactions; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Microinjections; Morphinans; Naltrexone; Prefrontal Cortex; Receptors, Opioid, delta | 2018 |
Targeting ulcerative colitis by suppressing glucose uptake with ritonavir.
Topics: Adult; Aged, 80 and over; Animals; Aspartic Acid; Biomarkers; CD4-Positive T-Lymphocytes; Colitis, Ulcerative; Disease Models, Animal; Female; Glucose; Glutamic Acid; Humans; Inflammation; Leukocytes; Male; Middle Aged; Phenotype; Principal Component Analysis; Ritonavir | 2018 |
Origanum vulgare essential oils inhibit glutamate and aspartate metabolism altering the photorespiratory pathway in Arabidopsis thaliana seedlings.
Topics: Arabidopsis; Aspartic Acid; Chlorophyll A; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Metabolic Networks and Pathways; Oils, Volatile; Origanum; Photosynthesis; Plant Oils; Plant Stomata; Seedlings | 2018 |
Altered function of the glutamate-aspartate transporter GLAST, a potential therapeutic target in glioblastoma.
Topics: Amino Acid Transport System X-AG; Animals; Apoptosis; Aspartic Acid; Astrocytes; Benzopyrans; Cell Line, Tumor; Cell Membrane; Excitatory Amino Acid Transporter 1; Female; Glioblastoma; Glioma; Glutamic Acid; Humans; Mice; Mice, Inbred C57BL; Protein Transport; Sodium-Potassium-Exchanging ATPase | 2019 |
Product Selectivity of Esterification of L-Aspartic Acid and L-Glutamic Acid Using Chlorotrimethylsilane.
Topics: Aspartic Acid; Catalysis; Esterification; Glutamic Acid; Trimethylsilyl Compounds | 2017 |
Metabolite differences between glutamate carboxypeptidase II gene knockout mice and their wild-type littermates after traumatic brain injury: a 7-tesla
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries, Traumatic; Disease Models, Animal; Glutamate Carboxypeptidase II; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Mice, Knockout; Proton Magnetic Resonance Spectroscopy | 2018 |
Neurochemical correlates of functional decline in amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Case-Control Studies; Disease Progression; Female; Glutamic Acid; Humans; Longitudinal Studies; Male; Middle Aged; Motor Cortex; Motor Neurons; Pons; Prognosis; Proton Magnetic Resonance Spectroscopy; Upper Extremity | 2019 |
Effect of acid deamidation-alcalase hydrolysis induced modification on functional and bitter-masking properties of wheat gluten hydrolysates.
Topics: Acetic Acid; Aspartic Acid; Bacterial Proteins; Glutamic Acid; Glutens; Hydrolysis; Least-Squares Analysis; Solubility; Subtilisins; Tartrates; Taste; Triticum | 2019 |
Molecular basis for increased lactate formation in the Müller glial cells of retina.
Topics: Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Cells, Cultured; Ependymoglial Cells; Glucose; Glutamic Acid; Glycolysis; Lactic Acid; Male; Mitochondria; Neuroglia; Neurons; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Retina | 2019 |
Aspartic and Glutamic Acid Templated Peptides Conjugation on Plasma Modified Nanofibers for Osteogenic Differentiation of Human Mesenchymal Stem Cells: A Comparative Study.
Topics: Aspartic Acid; Cell Differentiation; Cells, Cultured; Glutamic Acid; Humans; Mesenchymal Stem Cells; Microscopy, Electron, Scanning; Nanofibers; Osteogenesis; Peptides; Plasma Gases; Spectroscopy, Fourier Transform Infrared; Surface Tension | 2018 |
Different roles for aspartates and glutamates for cation permeation in bacterial sodium channels.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Bacterial Proteins; Calcium; Cations; Cell Membrane Permeability; CHO Cells; Cricetinae; Cricetulus; Glutamic Acid; Mutant Proteins; Sodium; Sodium Channels; Structure-Activity Relationship; Time Factors; Water | 2019 |
Brain Glutamate, GABA, and Glutamine Levels and Associations with Recent Drinking in Treatment-Naïve Individuals with Alcohol Use Disorder Versus Light Drinkers.
Topics: Adult; Alcohol Drinking; Alcoholism; Aspartic Acid; Case-Control Studies; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Male; Proton Magnetic Resonance Spectroscopy; Young Adult | 2019 |
Nucleus accumbens neurochemistry in human anxiety: A 7 T
Topics: Adult; Anxiety; Aspartic Acid; Correlation of Data; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Hydrocortisone; Male; Neurochemistry; Nucleus Accumbens; Personality; Proton Magnetic Resonance Spectroscopy; Psychiatric Status Rating Scales; Psychometrics; Saliva; Taurine; Tritium; Young Adult | 2019 |
Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in
Topics: Acetylation; Adenosine Triphosphate; Animals; Aspartic Acid; Caenorhabditis elegans; Citrate (si)-Synthase; Citric Acid; Citric Acid Cycle; Embryonic Development; Glutamic Acid; Intracellular Space; Mitochondrial Proteins; Time Factors | 2019 |
Assessing Brain Metabolism With 7-T Proton Magnetic Resonance Spectroscopy in Patients With First-Episode Psychosis.
Topics: Aspartic Acid; Brain; Case-Control Studies; Cross-Sectional Studies; Dipeptides; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Male; Neuropsychological Tests; Proton Magnetic Resonance Spectroscopy; Psychotic Disorders; Young Adult | 2019 |
Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice.
Topics: Administration, Intranasal; Aging; Animals; Antibodies; Aspartic Acid; Avoidance Learning; Conditioning, Psychological; Dopamine; Excitatory Amino Acid Antagonists; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Haptens; Hippocampus; Hydroxyindoleacetic Acid; Immunoconjugates; Locomotion; Male; Memory; Mice; Mice, Inbred C57BL; Rabbits; Serotonin; Serum Albumin, Bovine | 2019 |
Association between serum haptoglobin and carotid arterial functions: usefulness of a targeted metabolomics approach.
Topics: Adult; Aged; Aspartic Acid; Biomarkers; Carotid Artery Diseases; Carotid Intima-Media Thickness; Case-Control Studies; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Female; Glutamic Acid; Haptoglobins; Humans; Male; Metabolomics; Middle Aged; Phosphatidylcholines | 2019 |
Crucial residues in falcipains that mediate hemoglobin hydrolysis.
Topics: Aspartic Acid; Cloning, Molecular; Cysteine Endopeptidases; Glutamic Acid; Hemoglobins; Hydrolysis; Molecular Structure; Mutagenesis; Plasmodium falciparum | 2019 |
Validation of in vivo MRS measures of metabolite concentrations in the human brain.
Topics: Aspartic Acid; Brain; Dipeptides; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Humans; Magnetic Resonance Spectroscopy; Male; Metabolome; Young Adult | 2019 |
Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and subsequent epileptogenesis in two rat models of temporal lobe epilepsy.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Female; Glutamic Acid; Hippocampus; Lysine; Microdialysis; Neurotransmitter Agents; Pilocarpine; Rats; Scopolamine; Seizures; Status Epilepticus; Temporal Lobe | 2019 |
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men.
Topics: Aged; Alanine; Amino Acids; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Finland; Follow-Up Studies; Glutamic Acid; Humans; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Metabolomics; Middle Aged; Phenylalanine; Risk Factors; Tryptophan; Tyrosine; Valine | 2019 |
Dyslexia and age related effects in the neurometabolites concentration in the visual and temporo-parietal cortex.
Topics: Adult; Analysis of Variance; Aspartic Acid; Choline; Creatine; Dyslexia; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Male; Neurotransmitter Agents; Occipital Lobe | 2019 |
Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Excitatory Amino Acid Transporter 2; Glutamic Acid; Homeostasis; Mice; Mice, Knockout; Mitochondria; Neurons; Oxygen Consumption; Presynaptic Terminals; Synapses; Synaptosomes | 2019 |
White matter and hypoxic hypobaria in humans.
Topics: Adolescent; Adult; Air Pressure; Altitude Sickness; Aspartic Acid; Brain; Cerebrovascular Circulation; Diffusion Tensor Imaging; Glutamic Acid; Glutathione; Humans; Magnetic Resonance Spectroscopy; Male; Military Personnel; White Matter; Young Adult | 2019 |
Effect of glutamate and aspartate on ischemic heart disease, blood pressure, and diabetes: a Mendelian randomization study.
Topics: Aspartic Acid; Blood Pressure; Diabetes Mellitus; Dietary Supplements; Female; Genome-Wide Association Study; Glutamic Acid; Humans; Male; Mendelian Randomization Analysis; Myocardial Ischemia; Polymorphism, Single Nucleotide | 2019 |
Examining the molecular characteristics of glycoside hydrolase family 20 β-N-acetylglucosaminidases with high activity.
Topics: Acetylglucosaminidase; Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Biocatalysis; Glutamic Acid; Hydrolysis; Kinetics; Micrococcaceae; Paenibacillus; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Rhizobiaceae; Sequence Alignment; Sequence Homology, Amino Acid; Serratia marcescens; Streptomyces; Structure-Activity Relationship; Substrate Specificity | 2019 |
The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Embryo, Mammalian; Female; Glutamic Acid; GTP Phosphohydrolases; Humans; Metabolomics; Neurons; Optic Atrophy, Autosomal Dominant; Phospholipids; Primary Cell Culture; Rats; RNA, Small Interfering | 2019 |
Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression.
Topics: Aged; Aging; Antipsychotic Agents; Aspartic Acid; Biomarkers; Bipolar Disorder; Cerebral Cortex; Creatine; Depression; Energy Metabolism; Female; Follow-Up Studies; Glutamic Acid; Glutamine; Humans; Lamotrigine; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Severity of Illness Index; Treatment Outcome | 2019 |
Dynamics of in Vivo Metabolites Concentrations in Posttraumatic Period of Human Brain.
Topics: Adolescent; Aspartic Acid; Brain; Brain Injuries, Traumatic; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Male; Time Factors | 2019 |
Computational Studies on Water-Catalyzed Mechanisms for Stereoinversion of Glutarimide Intermediates Formed from Glutamic Acid Residues in Aqueous Phase.
Topics: Aspartic Acid; Catalysis; Drug Resistance; Glutamic Acid; Molecular Structure; Peptides; Piperidones; Proteins; Stereoisomerism; Succinimides; Water | 2019 |
Glutamate and aspartate alleviate testicular/epididymal oxidative stress by supporting antioxidant enzymes and immune defense systems in boars.
Topics: Animal Feed; Animals; Antioxidants; Aspartic Acid; Body Weight; Cytokines; Diet; Epididymis; Gene Expression Regulation; Glutamic Acid; Hydrogen Peroxide; Immune System; Male; Oxidative Stress; RNA, Messenger; Swine; Testis | 2020 |
Design of a Human Rhinovirus-14 3C Protease-Inducible Caspase-3.
Topics: 3C Viral Proteases; Aspartic Acid; Caspase 3; Catalytic Domain; Cysteine Endopeptidases; Glutamic Acid; Humans; Mutation; Protein Engineering; Rhinovirus; Viral Proteins | 2019 |
Metabolic characterization of diabetic retinopathy: An
Topics: Aged; Alanine; Antioxidants; Aqueous Humor; Area Under Curve; Aspartic Acid; Cataract; Diabetic Retinopathy; Female; Glutamic Acid; Humans; Male; Metabolomics; Middle Aged; Prospective Studies; Proton Magnetic Resonance Spectroscopy | 2019 |
Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer.
Topics: Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Aspartic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Excitatory Amino Acid Transporter 2; Female; Gas Chromatography-Mass Spectrometry; GATA2 Transcription Factor; Gene Expression Regulation, Neoplastic; Glutamic Acid; Humans; Mice; Mice, Inbred BALB C; MicroRNAs; Neoplasm Metastasis; Prognosis; Transcriptome; Transplantation, Heterologous | 2019 |
Longer Repetition Time Proton MR Spectroscopy Shows Increasing Hippocampal and Parahippocampal Metabolite Concentrations with Aging.
Topics: Adolescent; Adult; Aging; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Inositol; Male; Middle Aged; Parahippocampal Gyrus; Proton Magnetic Resonance Spectroscopy; Protons; Young Adult | 2019 |
Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex.
Topics: Aged; Aged, 80 and over; Aging; Aspartic Acid; Creatine; Diabetes Mellitus, Type 2; Female; Glucose; Glucose Intolerance; Glutamic Acid; Glutamine; Glutathione; Glycerylphosphorylcholine; Humans; Inositol; Insulin Resistance; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Neuronal Plasticity; Phosphocreatine; Phosphorylcholine; Prediabetic State; Theta Rhythm; Transcranial Magnetic Stimulation | 2019 |
Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose 4,6-dehydratase.
Topics: Adenosine Diphosphate Ribose; Amino Acid Motifs; Amino Acid Sequence; Ankyrin Repeat; Aspartic Acid; Binding Sites; Glutamic Acid; Humans; Hydro-Lyases; Multiprotein Complexes; Poly(ADP-ribose) Polymerases; Protein Binding; Protein Structure, Quaternary; Sequence Homology, Amino Acid; Shelterin Complex; Structure-Activity Relationship; Tankyrases; Telomere Homeostasis; Telomere-Binding Proteins; Wnt Signaling Pathway | 2019 |
Regional Metabolic Patterns of Abnormal Postoperative Behavioral Performance in Aged Mice Assessed by
Topics: Aging; Anesthesia; Animals; Anxiety; Aspartic Acid; Brain; Cerebral Cortex; Cognitive Dysfunction; Female; Glutamic Acid; Hippocampus; Isoflurane; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Motor Activity; Proton Magnetic Resonance Spectroscopy | 2020 |
A novel thermostable D-amino acid oxidase of the thermophilic fungus Rasamsonia emersonii strain YA.
Topics: Amino Acid Sequence; Ascomycota; Aspartic Acid; Catalytic Domain; Cephalosporins; Cloning, Molecular; D-Amino-Acid Oxidase; Enzyme Assays; Enzyme Stability; Escherichia coli; Fungal Proteins; Gene Expression; Genetic Vectors; Glutamic Acid; Hydrophobic and Hydrophilic Interactions; Kinetics; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity | 2019 |
Adolescent-onset heavy cannabis use associated with significantly reduced glial but not neuronal markers and glutamate levels in the hippocampus.
Topics: Adult; Alcohol Oxidoreductases; Aspartic Acid; Biomarkers; Cannabis; Female; Glutamic Acid; Hippocampus; Humans; Inositol; Male; Marijuana Abuse; Neuroglia; Neurons; Young Adult | 2020 |
Cingulate glutamate levels associate with pain in chronic pancreatitis patients.
Topics: Abdominal Pain; Aged; Aspartic Acid; Cerebral Cortex; Creatine; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pancreatitis, Chronic | 2019 |
Bioanalytical methodology for determination of glutamate and aspartate for use in pharmacological sciences with application of Integrated Calibration Method.
Topics: Animals; Aspartic Acid; Calibration; Chromatography, High Pressure Liquid; Electrochemical Techniques; Glutamic Acid; Male; Mice, Inbred C57BL; Microdialysis; Neurotransmitter Agents; Rats, Wistar | 2020 |
Chemoperception of Specific Amino Acids Controls Phytopathogenicity in Pseudomonas syringae pv. tomato.
Topics: Aspartic Acid; Biofilms; Chemotaxis; Genes, Plant; Glutamic Acid; Guanosine Monophosphate; Ligands; Plant Diseases; Pseudomonas syringae; Solanum lycopersicum; Virulence | 2019 |
A Mutation in the Mitochondrial Aspartate/Glutamate Carrier Leads to a More Oxidizing Intramitochondrial Environment and an Inflammatory Myopathy in Dutch Shepherd Dogs.
Topics: Amino Acid Transport Systems, Acidic; Animals; Antiporters; Aspartic Acid; Dermatomyositis; Dog Diseases; Dogs; Glutamic Acid; Humans; Mitochondria; Mutation; Myositis; Oxidation-Reduction; Polymyositis | 2019 |
Site-specific analysis of the Asp- and Glu-ADP-ribosylated proteome by quantitative mass spectrometry.
Topics: ADP-Ribosylation; Aspartic Acid; Cell Culture Techniques; Glutamic Acid; HEK293 Cells; Humans; Mass Spectrometry; Proteome; Proteomics; Tandem Mass Spectrometry | 2019 |
Altered hypothalamic metabolism in early multiple sclerosis - MR spectroscopy study.
Topics: Adult; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Hypothalamus; Inositol; Magnetic Resonance Spectroscopy; Male; Multiple Sclerosis; Young Adult | 2019 |
The impact of endurance training and table soccer on brain metabolites in schizophrenia.
Topics: Adult; Aspartic Acid; Brain; Cognition; Creatine; Endurance Training; Female; Glutamic Acid; Glutamine; Hippocampus; Humans; Inpatients; Magnetic Resonance Spectroscopy; Male; Neurons; Prefrontal Cortex; Schizophrenia; Thalamus | 2020 |
Short echo-time Magnetic Resonance Spectroscopy in ALS, simultaneous quantification of glutamate and GABA at 3 T.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Atrophy; Choline; Creatine; Disease Progression; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Gray Matter; Hand Strength; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Cortex; Occipital Lobe; Pilot Projects; Severity of Illness Index; Single-Blind Method | 2019 |
Biosynthesis of the N-N-Bond-Containing Compound l-Alanosine.
Topics: Alanine; Aspartic Acid; Glutamic Acid; Molecular Structure; Multigene Family; Streptomyces | 2020 |
Magnetic resonance spectroscopy across chronic pain disorders: a systematic review protocol synthesising anatomical and metabolite findings in chronic pain patients.
Topics: Aspartic Acid; Brain; Chronic Pain; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Image Processing, Computer-Assisted; Proton Magnetic Resonance Spectroscopy; Systematic Reviews as Topic | 2019 |
A Magnetic Resonance Spectroscopy Study of Superior Visual Search Abilities in Children with Autism Spectrum Disorder.
Topics: Adolescent; Aspartic Acid; Attention; Autism Spectrum Disorder; Brain; Child; Creatine; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Visual Perception | 2020 |
pH-Dependent Protonation of Surface Carboxylate Groups in PsbO Enables Local Buffering and Triggers Structural Changes.
Topics: Aspartic Acid; Bacterial Proteins; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Gene Expression; Genetic Vectors; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Models, Molecular; Oxygen; Photosynthesis; Photosystem II Protein Complex; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Protein Subunits; Protons; Recombinant Proteins; Thermodynamics; Thermosynechococcus; Water | 2020 |
Dogs are resistant to prion infection, due to the presence of aspartic or glutamic acid at position 163 of their prion protein.
Topics: Animals; Aspartic Acid; Biological Assay; Brain; Dogs; Glutamic Acid; Mice; Plasma Membrane Calcium-Transporting ATPases; Prions | 2020 |
Modeling amino-acid side chain infrared spectra: the case of carboxylic residues.
Topics: Amino Acids; Aspartic Acid; Glutamic Acid; Molecular Dynamics Simulation; Proteins; Quantum Theory; Spectrophotometry, Infrared | 2020 |
Reduced Hippocampal Glutamate and Posterior Cingulate N-Acetyl Aspartate in Mild Cognitive Impairment and Alzheimer's Disease Is Associated with Episodic Memory Performance and White Matter Integrity in the Cingulum: A Pilot Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Cognitive Dysfunction; Diffusion Tensor Imaging; Female; Glutamic Acid; Gyrus Cinguli; Hippocampus; Humans; Limbic System; Magnetic Resonance Spectroscopy; Male; Memory, Episodic; Mental Status and Dementia Tests; Middle Aged; Neuropsychological Tests; Pilot Projects; White Matter | 2020 |
Astrocytic glutamate transporters reduce the neuronal and physiological influence of metabotropic glutamate receptors in nucleus tractus solitarii.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Neurons; Receptors, Metabotropic Glutamate; Solitary Nucleus; Synaptic Transmission | 2020 |
Structure and dynamics at N- and C-terminal regions of intrinsically disordered human c-Myc PEST degron reveal a pH-induced transition.
Topics: Amino Acid Sequence; Aspartic Acid; Cloning, Molecular; Cysteine; Escherichia coli; Gene Expression; Genetic Vectors; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Indoles; Intrinsically Disordered Proteins; Molecular Dynamics Simulation; Neoplasm Proteins; Phosphatidylcholines; Protein Folding; Protein Structure, Secondary; Proto-Oncogene Proteins c-myc; Recombinant Proteins; Spectrometry, Fluorescence; Staining and Labeling; Tryptophan | 2020 |
Amyloid Fibril-Induced Astrocytic Glutamate Transporter Disruption Contributes to Complement C1q-Mediated Microglial Pruning of Glutamatergic Synapses.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Astrocytes; CA1 Region, Hippocampal; Ceftriaxone; Cognition Disorders; Complement C1q; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Male; Microglia; Morris Water Maze Test; Neurons; Patch-Clamp Techniques; Peptide Fragments; Phagocytosis; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses; Up-Regulation | 2020 |
A Dietary Ketone Ester Normalizes Abnormal Behavior in a Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Brain; Citric Acid Cycle; Diet; Disease Models, Animal; Esters; Glucose; Glutamic Acid; Hippocampus; Ketone Bodies; Ketones; Ketosis; Male; Mice | 2020 |
N-Acetylaspartate Is an Important Brain Osmolyte.
Topics: Aspartic Acid; Biomarkers; Brain Chemistry; Choline; Creatine; Glutamic Acid; Glutamine; Humans; Hydrogen-Ion Concentration; Inositol; Muramidase; Neurons; Osmosis; Protein Unfolding; Temperature; Thermodynamics | 2020 |
Binding of the periplakin linker requires vimentin acidic residues D176 and E187.
Topics: Amino Acid Sequence; Amino Acids, Acidic; Aspartic Acid; Glutamic Acid; HeLa Cells; Humans; Intermediate Filaments; Models, Molecular; Mutation, Missense; Plakins; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Quaternary; Vimentin | 2020 |
Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply.
Topics: Animals; Aspartic Acid; Brain; Calcium; Calcium Channels; Cytosol; Glutamic Acid; Heart; Malates; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Myocardium; Oxidative Phosphorylation; Pyruvic Acid; Rats; Substrate Specificity; Synaptosomes | 2020 |
Pre-mounted dry TAVI valve with improved endothelialization potential using REDV-loaded PEGMA hydrogel hybrid pericardium.
Topics: Animals; Arginine; Aspartic Acid; Cells, Cultured; Glutamic Acid; Humans; Hydrogels; Male; Materials Testing; Methacrylates; Molecular Structure; Particle Size; Pericardium; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Surface Properties; Transcatheter Aortic Valve Replacement; Valine | 2020 |
Altered neurometabolism in major depressive disorder: A whole brain
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; Energy Metabolism; Female; Glutamic Acid; Glutamine; Humans; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Young Adult | 2020 |
MRS Shows Regionally Increased Glutamate Levels among Patients with Exhaustion Syndrome Due to Occupational Stress.
Topics: Adjustment Disorders; Adult; Amygdala; Aspartic Acid; Brain; Brain Cortical Thickness; Burnout, Professional; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Insular Cortex; Male; Middle Aged; Occupational Stress; Parietal Lobe; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Sex Factors | 2020 |
Glutamatergic hypo-function in the left superior and middle temporal gyri in early schizophrenia: a data-driven three-dimensional proton spectroscopic imaging study.
Topics: Aspartic Acid; Creatine; Glutamic Acid; Glutamine; Humans; Proton Magnetic Resonance Spectroscopy; Protons; Schizophrenia | 2020 |
Brain proton magnetic resonance spectroscopy findings in a Beagle dog with genetically confirmed Lafora disease.
Topics: Animals; Aspartic Acid; Brain; Choline; Dog Diseases; Dogs; Ethanolamines; Female; Glutamic Acid; Glutamine; Lafora Disease; Magnetic Resonance Imaging; Proton Magnetic Resonance Spectroscopy | 2020 |
Insights on the participation of Glu256 and Asp204 in the oligomeric structure and cooperative effects of human arginase type I.
Topics: Arginase; Arginine; Aspartic Acid; Glutamic Acid; Humans; Kinetics; Macromolecular Substances; Models, Molecular; Mutation; Protein Conformation; Protein Multimerization | 2020 |
An acidic residue reactive and disulfide bond-containing cleavable cross-linker for probing protein 3D structures based on electrochemical mass spectrometry.
Topics: Aspartic Acid; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Disulfides; Electrochemical Techniques; Glutamic Acid; Imaging, Three-Dimensional; Mass Spectrometry; Proteins | 2020 |
Polarized light through polycrystalline vaterite helicoids.
Topics: Anisotropy; Aspartic Acid; Calcium Carbonate; Crystallization; Glutamic Acid; Humans; Microscopy, Polarization; Models, Theoretical; Molecular Conformation; Nanostructures; Structure-Activity Relationship; Surface Properties | 2020 |
Evaluation of anti-biofilm activity of acidic amino acids and synergy with ciprofloxacin on Staphylococcus aureus biofilms.
Topics: Anti-Bacterial Agents; Aspartic Acid; Bacterial Adhesion; Biofilms; Ciprofloxacin; Colony Count, Microbial; Dose-Response Relationship, Drug; Drug Synergism; Glutamic Acid; Microbial Sensitivity Tests; Staphylococcus aureus | 2020 |
Determination of Brain Metabolite T
Topics: Adult; Aspartic Acid; Brain; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Prospective Studies; Young Adult | 2020 |
Substitution of high-dose sucrose with fructose in high-fat diets resulted in higher plasma concentrations of aspartic acid, cystine, glutamic acid, ornithine and phenylalanine, and higher urine concentrations of arginine and citrulline.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Blood Glucose; Citrulline; Cystine; Diet, High-Fat; Dietary Sucrose; Dietary Sugars; Fructose; Glutamic Acid; Lipids; Male; Ornithine; Phenylalanine; Rats; Rats, Wistar | 2020 |
Oxidation of energy substrates in tissues of largemouth bass (Micropterus salmoides).
Topics: Adenosine Triphosphate; Amino Acids; Animals; Aspartic Acid; Bass; Glucose; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Leucine; Liver; Muscle, Skeletal; Oxidation-Reduction; Palmitates; Transaminases; Tromethamine | 2020 |
Neurochemistry of hyponatremic encephalopathy evaluated by MR spectroscopy.
Topics: Aspartic Acid; Child; Creatine; Glutamic Acid; Glutamine; Hepatic Encephalopathy; Humans; Hyponatremia; Inositol; Magnetic Resonance Spectroscopy; Male; Neurochemistry; Phosphocreatine; Sodium | 2020 |
Changes in the intracellular microenvironment in the aging human brain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aspartic Acid; Brain; Brain Chemistry; Cellular Microenvironment; Choline; Creatine; Female; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Young Adult | 2020 |
Metabolomics approach revealed robust changes in amino acid and biogenic amine signatures in patients with schizophrenia in the early course of the disease.
Topics: Adult; Amino Acids; Antipsychotic Agents; Asparagine; Aspartic Acid; Biogenic Amines; Chromatography, Liquid; Early Diagnosis; Female; Glutamic Acid; Glutamine; Humans; Male; Metabolome; Metabolomics; Proline; Schizophrenia; Tandem Mass Spectrometry; Taurine; Young Adult | 2020 |
Altered thalamic neurotransmitters metabolism and functional connectivity during the development of chronic constriction injury induced neuropathic pain.
Topics: Animals; Aspartic Acid; Constriction; Glutamic Acid; Hyperalgesia; Neuralgia; Neurotransmitter Agents; Rats; Thalamus; Wounds and Injuries | 2020 |
The Relationship between the Level of Anterior Cingulate Cortex Metabolites, Brain-Periphery Redox Imbalance, and the Clinical State of Patients with Schizophrenia and Personality Disorders.
Topics: Adult; Antioxidants; Aspartic Acid; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Male; Malondialdehyde; Oxidants; Oxidation-Reduction; Oxidative Stress; Personality Disorders; Prognosis; Psychotic Disorders; Schizophrenia; Young Adult | 2020 |
Investigating the calcium binding characteristics of black bean protein hydrolysate.
Topics: Aspartic Acid; Bromelains; Calcium; Calcium-Binding Proteins; Dietary Supplements; Ficain; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Hydrolysis; Phaseolus; Protein Hydrolysates; Spectrum Analysis; Subtilisins; Trypsin | 2020 |
Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Choline; Depressive Disorder; Dietary Supplements; Disease Progression; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glutathione; Lacticaseibacillus rhamnosus; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Wistar; Stress, Psychological | 2020 |
L-Aspartate as a high-quality nitrogen source in Escherichia coli: Regulation of L-aspartase by the nitrogen regulatory system and interaction of L-aspartase with GlnB.
Topics: Ammonia; Aspartate Ammonia-Lyase; Aspartic Acid; Bacterial Proteins; Dicarboxylic Acid Transporters; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Glutamic Acid; Glutamine; Ketoglutaric Acids; Metabolic Networks and Pathways; Mutation; Nitrogen; PII Nitrogen Regulatory Proteins; Protein Interaction Domains and Motifs | 2021 |
Disrupted Coupling Between NAA and Functional Connectivity in Ventromedial Prefrontal Cortex of Drug-Naïve First-Episode Psychosis.
Topics: Aspartic Acid; Glutamic Acid; Humans; Prefrontal Cortex; Psychoses, Substance-Induced | 2020 |
Saturation transfer difference NMR on the integral trimeric membrane transport protein GltPh determines cooperative substrate binding.
Topics: Amino Acid Transport Systems; Animals; Aspartic Acid; Biological Transport; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Mammals; Membrane Proteins; Membrane Transport Proteins; Proteolipids; Pyrococcus horikoshii; Substrate Specificity | 2020 |
N,N'-Diphenylthiourea electrochemical sensor for the detection of l-glutamate and Aspartate in beef.
Topics: Animals; Aspartic Acid; Cattle; Electrochemical Techniques; Glutamic Acid; Red Meat; Reproducibility of Results; Thiourea | 2020 |
Neurotransmitters and Neurometabolites in Late-Life Depression: A Preliminary Magnetic Resonance Spectroscopy Study at 7T.
Topics: Aspartic Acid; Creatine; Depression; Depressive Disorder, Major; Glutamic Acid; Gyrus Cinguli; Humans; Infant; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neurotransmitter Agents; Proton Magnetic Resonance Spectroscopy | 2021 |
The neurobiology of wellness:
Topics: Adaptation, Psychological; Adult; Affect; Aspartic Acid; Choline; Cognitive Reserve; Creatine; Emotions; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Healthy Volunteers; Humans; Inositol; Male; Mental Health; Personality Inventory; Principal Component Analysis; Proton Magnetic Resonance Spectroscopy; Young Adult | 2021 |
Glutamate metabolism in a human intestinal epithelial cell layer model.
Topics: Alanine; Amino Acids; Aspartic Acid; Caco-2 Cells; Diet; Epithelial Cells; Glutamic Acid; Glutamine; Humans; Intestinal Mucosa; Permeability | 2020 |
Daily and intermittent smoking are associated with low prefrontal volume and low concentrations of prefrontal glutamate, creatine, myo-inositol, and N-acetylaspartate.
Topics: Adult; Aspartic Acid; Choline; Cigarette Smoking; Creatine; Female; Glutamic Acid; Gray Matter; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Prefrontal Cortex; Young Adult | 2021 |
Effects of conserved Arg20, Glu74 and Asp77 on the structure and function of a tau class glutathione S-transferase in rice.
Topics: Amino Acid Sequence; Amino Acids; Arginine; Aspartic Acid; Catalytic Domain; Enzyme Stability; Glutamic Acid; Glutathione; Glutathione Transferase; Models, Molecular; Mutation; Oryza; Plant Proteins; Protein Domains; Sequence Homology, Amino Acid; Substrate Specificity | 2021 |
Autophagy sustains glutamate and aspartate synthesis in Saccharomyces cerevisiae during nitrogen starvation.
Topics: Ammonium Compounds; Aspartic Acid; Autophagy; Glutamate Synthase (NADH); Glutamic Acid; Macromolecular Substances; Models, Biological; Mutation; Nitrogen; Nucleic Acids; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus | 2021 |
Rapid access to Asp/Glu sidechain hydrazides as thioester precursors for peptide cyclization and glycosylation.
Topics: Aspartic Acid; Cyclization; Glutamic Acid; Glycosylation; Macrocyclic Compounds; Peptides, Cyclic; Protein Conformation | 2021 |
Topics: Adult; Aspartic Acid; Astrocytes; Autism Spectrum Disorder; Biomarkers; Cerebral Cortex; Dipeptides; Female; Glutamic Acid; Humans; Male; Neurons; Oligodendroglia; Proton Magnetic Resonance Spectroscopy; Young Adult | 2021 |
Effects of brainstem lesions on amino acid levels in the rat cochlear nucleus.
Topics: Amino Acids; Animals; Aspartic Acid; Cochlear Nucleus; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Olivary Nucleus; Rats | 2021 |
An investigation of glutamate quantification with PRESS and MEGA-PRESS.
Topics: Aspartic Acid; Computer Simulation; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Inositol; Nuclear Magnetic Resonance, Biomolecular; Phantoms, Imaging; Phosphocreatine; Taurine | 2021 |
MCH-R1 Antagonist GPS18169, a Pseudopeptide, Is a Peripheral Anti-Obesity Agent in Mice.
Topics: Adipose Tissue; Alkynes; Aminobutyrates; Animals; Anti-Obesity Agents; Appetite; Aspartic Acid; Disease Models, Animal; Drug Discovery; Glutamic Acid; Glycine; HEK293 Cells; Hepatocytes; Homeostasis; Humans; Insulin; Lactams; Male; Mice; Mice, Inbred C57BL; Obesity; Rats; Receptors, Pituitary Hormone; Structure-Activity Relationship; Tissue Distribution; Triazoles | 2021 |
Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) Imaging in Obsessive-Compulsive Disorder.
Topics: Aspartic Acid; Creatine; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Obsessive-Compulsive Disorder; Positron-Emission Tomography | 2021 |
Optimal pH shift of the NADH oxidase from Lactobacillus rhamnosus with a single mutation.
Topics: Amino Acid Substitution; Arginine; Aspartic Acid; Bacterial Proteins; Binding Sites; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Lacticaseibacillus rhamnosus; Models, Molecular; Molecular Docking Simulation; Multienzyme Complexes; Mutagenesis, Site-Directed; NAD; NADH, NADPH Oxidoreductases; Protein Conformation; Protein Engineering; Substrate Specificity | 2021 |
Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytes; Brain Neoplasms; Female; Glioma; Glutamic Acid; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Spectroscopy; Male; Metabolome; Middle Aged; Multivariate Analysis; Mutation; Oligodendroglia; Seizures; Survival Analysis; Young Adult | 2021 |
Alteration of cofactor specificity of the acrylyl-CoA reductase from Escherichia coli.
Topics: Amino Acid Substitution; Arginine; Aspartic Acid; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Mutagenesis, Site-Directed; NAD; NADP; Protein Engineering; Quinone Reductases; Serine; Substrate Specificity | 2021 |
COVID-19-related cognitive dysfunction may be associated with transient disruption in the DLPFC glutamatergic pathway.
Topics: Adult; Aspartic Acid; Cognitive Dysfunction; COVID-19; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Prefrontal Cortex; Signal Transduction | 2021 |
Observing spontaneous, accelerated substrate binding in molecular dynamics simulations of glutamate transporters.
Topics: Amino Acid Transport System X-AG; Aspartic Acid; Binding Sites; Excitatory Amino Acid Transporter 1; Glutamic Acid; Humans; Molecular Dynamics Simulation; Protein Binding; Substrate Specificity | 2021 |
How adding a single methylene to dihydrofolate reductase can change its conformational dynamics.
Topics: Aspartic Acid; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Hydrogen Bonding; Molecular Dynamics Simulation; Mutation; Pressure; Protein Conformation; Tetrahydrofolate Dehydrogenase | 2021 |
Effects of Bisphenol A and Bisphenol S Exposure at Low Doses on the Metabolome of Adolescent Male Sprague-Dawley Rats.
Topics: Alanine; Animals; Aspartic Acid; Benzhydryl Compounds; Butyrates; Citric Acid Cycle; Dose-Response Relationship, Drug; Glutamic Acid; Glycerophospholipids; Male; Phenols; Rats; Rats, Sprague-Dawley; Sulfones | 2021 |
Delayed Behavioral and Neurochemical Effects of Anti-Glutamate Antibodies in Aging C57BL/6 Mice.
Topics: Aging; Animals; Aspartic Acid; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL | 2021 |
Substrate usage determines carbon flux via the citrate cycle in Helicobacter pylori.
Topics: Acetyl Coenzyme A; Amino Acids; Aspartic Acid; Carbohydrate Metabolism; Carbon; Carbon Cycle; Citric Acid; Citric Acid Cycle; Glucose; Glutamic Acid; Glyceraldehyde; Glyoxylates; Helicobacter Infections; Helicobacter pylori; Humans; Malates; Metabolic Networks and Pathways; Succinic Acid | 2021 |
Metabolic abnormality in acute stroke-like lesion and its relationship with focal cerebral blood flow in patients with MELAS: Evidence from proton MR spectroscopy and arterial spin labeling.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Case-Control Studies; Choline; Creatine; Female; Glutamic Acid; Glutamine; Humans; Lactic Acid; Male; MELAS Syndrome; Metabolomics; Middle Aged; Prospective Studies; Proton Magnetic Resonance Spectroscopy; Spin Labels; Young Adult | 2021 |
Gut bacterial gene changes following pegaspargase treatment in pediatric patients with acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Genes, Bacterial; Glutamic Acid; Glutamine; Humans; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
The Role of Acidic Residues in the C Terminal Tail of the LHCSR3 Protein of
Topics: Algal Proteins; Aspartic Acid; Carotenoids; Chlamydomonas reinhardtii; Chlorophyll; Energy Transfer; Glutamic Acid; Light; Light-Harvesting Protein Complexes; Mutation | 2021 |
Evaluation of Cocaine Effect on Endogenous Metabolites of HepG2 Cells Using Targeted Metabolomics.
Topics: Alanine; Aspartic Acid; Biomarkers; Chromatography, Liquid; Cocaine; Glutamic Acid; Hep G2 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Metabolic Networks and Pathways; Metabolome; Metabolomics; Multivariate Analysis; Tandem Mass Spectrometry; Taurine | 2021 |
Comprehensive metabolomics profiling reveals common metabolic alterations underlying the four major non-communicable diseases in treated HIV infection.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Atherosclerosis; Cognitive Dysfunction; Female; Glutamic Acid; Glutamine; Glycerophospholipids; HIV Infections; Humans; Liver Cirrhosis; Male; Metabolome; Middle Aged; Plasmalogens; Renal Insufficiency | 2021 |
Three Reasons Why Aspartic Acid and Glutamic Acid Sequences Have a Surprisingly Different Influence on Mineralization.
Topics: Aspartic Acid; Calcium; Glutamic Acid; Ions; Peptides | 2021 |
The effects of low pH on the taste and amino acid composition of tiger shrimp.
Topics: Animals; Aspartic Acid; Climate Change; Crassostrea; Glutamic Acid; Hydrogen-Ion Concentration; Seafood; Seawater | 2021 |
Regional Differences in Gamma-Aminobutyric Acid and Glutamate Concentrations in the Healthy Newborn Brain.
Topics: Aspartic Acid; Brain; Cross-Sectional Studies; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Infant; Infant, Newborn; Magnetic Resonance Spectroscopy | 2022 |
The ability of carbon nanoparticles to increase transmembrane current of cations coincides with impaired synaptic neurotransmission.
Topics: Alanine; Animals; Aspartic Acid; Carbon; Carbon Radioisotopes; Cations; Cerebral Cortex; Cholesterol; gamma-Aminobutyric Acid; Glutamic Acid; Lipid Bilayers; Nanodiamonds; Nanoparticles; Neurotransmitter Agents; Rats; Synapses; Synaptic Transmission; Synaptic Vesicles | 2022 |
The main oxidative inactivation pathway of the plant hormone auxin.
Topics: Amidohydrolases; Amino Acids; Arabidopsis; Arabidopsis Proteins; Aspartic Acid; Dioxygenases; Gene Expression Regulation, Plant; Glutamic Acid; Homeostasis; Hydrolysis; Indoleacetic Acids; Oxidation-Reduction; Oxidative Stress; Oxindoles; Plant Development; Plant Growth Regulators; Signal Transduction | 2021 |
Inverse Association Between Hypothalamic N-Acetyl Aspartate/Creatine Ratio and Indices of Body Mass in Adolescents with Obesity.
Topics: Adolescent; Aspartic Acid; Case-Control Studies; Child; Choline; Creatine; Cytokines; Glutamic Acid; Hormones; Humans; Pediatric Obesity | 2022 |
African Swine Fever Virus Regulates Host Energy and Amino Acid Metabolism To Promote Viral Replication.
Topics: African Swine Fever; African Swine Fever Virus; Amino Acids; Animals; Aspartic Acid; Citric Acid Cycle; Energy Metabolism; Glutamic Acid; Host-Pathogen Interactions; Lactic Acid; Macrophages, Alveolar; Metabolomics; Swine; Virus Replication | 2022 |
Abnormal neurobiochemical metabolites in the first
Topics: Aspartic Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Proton Magnetic Resonance Spectroscopy; Schizophrenia | 2021 |
Magnetic resonance spectroscopic evidence of increased choline in the dorsolateral prefrontal and visual cortices in recent onset schizophrenia.
Topics: Adolescent; Adult; Aspartic Acid; Choline; Creatine; Female; Glutamic Acid; Humans; Magnetic Resonance Imaging; Male; Prefrontal Cortex; Schizophrenia; Visual Cortex | 2022 |
The glutamate/N-methyl-d-aspartate receptor (NMDAR) model of schizophrenia at 35: On the path from syndrome to disease.
Topics: Aspartic Acid; Glutamic Acid; Humans; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2022 |
Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Glutamic Acid; Male; Migraine Disorders; N-Methylaspartate; Nociception; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Trigeminal Ganglion | 2022 |
Oxidation of amino acids, glucose, and fatty acids as metabolic fuels in enterocytes of post-hatching developing chickens.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Butyrates; Chickens; Enterocytes; Fatty Acids; Glucose; Glutamic Acid; Glutamine; Palmitates; Propionates | 2022 |
Pathway-based metabolomics study of sarcopenia-related traits in two US cohorts.
Topics: Aspartic Acid; Female; Glutamic Acid; Humans; Male; Metabolomics; Muscle Strength; Sarcopenia | 2022 |
Oxidation of amino acids, glucose, and fatty acids as metabolic fuels in enterocytes of developing pigs.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Butyrates; Enterocytes; Fatty Acids; Glucose; Glutamic Acid; Glutamine; Palmitates; Propionates; Swine | 2022 |
Effects of glutamate and aspartate on prostate cancer and breast cancer: a Mendelian randomization study.
Topics: Adult; Aspartic Acid; Breast Neoplasms; Glutamic Acid; Humans; Male; Mendelian Randomization Analysis; Prostatic Neoplasms | 2022 |
Carbon uptake bioenergetics of PAOs and GAOs in full-scale enhanced biological phosphorus removal systems.
Topics: Acetates; Actinomycetales; Adenosine Triphosphatases; Aspartic Acid; Betaproteobacteria; Bioreactors; Carbon; Energy Metabolism; Glutamic Acid; Glycogen; Phosphorus; Polyphosphates; Propionates; Propionibacteriaceae; RNA, Ribosomal, 16S; Succinate Dehydrogenase | 2022 |
POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function.
Topics: Adaptor Proteins, Signal Transducing; Animals; Aspartic Acid; Cytoskeletal Proteins; Disks Large Homolog 4 Protein; Glutamic Acid; Mice; Nerve Tissue Proteins; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2022 |
Fish proteins as potential precursors of taste-active compounds: an in silico study.
Topics: Amino Acids; Animals; Aspartic Acid; Fish Proteins; Food Ingredients; Glutamic Acid; Papain; Parvalbumins; Peptides; Protein Hydrolysates; Taste | 2022 |
Measurement of glucose metabolism in the occipital lobe and frontal cortex after oral administration of [1-13C]glucose at 9.4 T.
Topics: Administration, Oral; Amino Acids; Aspartic Acid; Brain; Carbon Isotopes; Frontal Lobe; Glucose; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Occipital Lobe | 2022 |
Asp50Glu mutation in MurA results in fosfomycin resistance in Enterococcus faecium.
Topics: Alkyl and Aryl Transferases; Amino Acid Substitution; Anti-Bacterial Agents; Aspartic Acid; Bacterial Proteins; Drug Resistance, Bacterial; Enterococcus faecium; Fosfomycin; Glutamic Acid; Mutation | 2022 |
Structural Aspects of
Topics: Asparaginase; Aspartic Acid; Dickeya chrysanthemi; Escherichia coli; Glutamic Acid; Glutamine | 2022 |
Characterization of Animal Protein-Based Binders in Ancient Chinese Wall Paintings Using Atomic Force Microscopy and Fourier Transform Infrared Spectroscopy.
Topics: Animals; Aspartic Acid; Bone Cements; Cattle; China; Female; Glutamic Acid; Microscopy, Atomic Force; Paintings; Proteins; Serine; Sheep; Spectroscopy, Fourier Transform Infrared | 2022 |
Bioconjugation Strategies for Tobacco Mild Green Mosaic Virus.
Topics: Aspartic Acid; Glutamic Acid; Nicotiana; Protein Subunits; RNA, Viral; Solvents; Tobacco Mosaic Virus; Tyrosine | 2022 |
Evidence of persistent glial cell dysfunction in the anterior cingulate cortex of juvenile idiopathic arthritis children: a proton MRS study.
Topics: Arthritis, Juvenile; Aspartic Acid; Child; Choline; Creatine; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Neuroglia; Protons | 2022 |
1α,25-dihydroxyvitamin D reduction of MCF10A-ras cell viability in extracellular matrix detached conditions is dependent on regulation of pyruvate carboxylase.
Topics: Aspartic Acid; Cell Survival; Doxycycline; Extracellular Matrix; Glucose; Glutamic Acid; Glutamine; Malates; Pyruvate Carboxylase; RNA, Messenger; RNA, Small Interfering; Vitamin D | 2022 |
Temperature effect on calcium binding to aspartate and glutamate.
Topics: Aspartic Acid; Calcium; Calcium, Dietary; Glutamic Acid; Temperature; Thermodynamics | 2022 |
Peripheral N-methyl-D-aspartate receptor activation contributes to monosodium glutamate-induced headache but not nausea behaviours in rats.
Topics: Amino Acids; Animals; Aspartic Acid; Female; Glutamic Acid; Headache; Kynurenic Acid; Male; Metoclopramide; Nausea; Ondansetron; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Glutamate | 2022 |
Multiomics assessment of dietary protein titration reveals altered hepatic glucose utilization.
Topics: Animals; Aspartic Acid; Dietary Proteins; Gluconeogenesis; Glucose; Glutamic Acid; Glycerol; Liver; Mice; Serine | 2022 |
Neurometabolic changes in neonates with congenital heart defects and their relation to neurodevelopmental outcome.
Topics: Aspartic Acid; Brain; Cerebral Cortex; Choline; Creatine; Glutamic Acid; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Magnetic Resonance Spectroscopy | 2023 |
Rapid, sensitive analysis method for determining the nitrogen stable isotope ratio of total free amino acids in soil.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cysteine; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Histidine; Leucine; Lysine; Nitrogen; Nitrogen Isotopes; Phenylalanine; Serine; Soil; Tryptophan | 2022 |
Topics: Aged; Alzheimer Disease; Aspartic Acid; Cognition; Cognitive Dysfunction; Creatine; Glutamic Acid; Humans; Inositol; Proton Magnetic Resonance Spectroscopy | 2022 |
Phenotype microarray analysis reveals the biotransformation of Fusarium oxysporum f.sp. lycopersici influenced by Bacillus subtilis PBE-8 metabolites.
Topics: Alanine; Ammonia; Antifungal Agents; Arginine; Aspartic Acid; Bacillus subtilis; Biotransformation; Carbon; Fusarium; Glutamic Acid; Glutamine; Glycine; Isoleucine; Leucine; Linoleic Acids; Linolenic Acids; Microarray Analysis; Nitrogen; Phenotype; Plant Diseases; Proline; RNA, Transfer; Solanum lycopersicum; Valine | 2022 |
Reversible Glutamate Coordination to High-Valent Nickel Protects the Active Site of a [NiFe] Hydrogenase from Oxygen.
Topics: Alanine; Aspartic Acid; Catalytic Domain; Glutamic Acid; Glutamine; Hydrogenase; Hydrogenophilaceae; Iron; Ligands; NAD; Nickel; Oxidation-Reduction; Oxygen | 2022 |
Regional metabolic heterogeneity in anterior cingulate cortex in major depressive disorder: A multi-voxel
Topics: Aspartic Acid; Depressive Disorder, Major; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Magnetic Resonance Spectroscopy; Proton Magnetic Resonance Spectroscopy; Young Adult | 2022 |
Quantitative measurement of peritumoral concentrations of glutamate, N-acetyl aspartate, and lactate on magnetic resonance spectroscopy predicts glioblastoma-related refractory epilepsy.
Topics: Aspartic Acid; Creatine; Drug Resistant Epilepsy; Epilepsy, Temporal Lobe; Glioblastoma; Glutamic Acid; Humans; Lactic Acid; Magnetic Resonance Spectroscopy | 2022 |
Toxicity effects of chlorantraniliprole in zebrafish (Danio rerio) involving in liver function and metabolic phenotype.
Topics: Alanine; Animals; Aspartic Acid; Glutamic Acid; Glutamine; Insecticides; Isoleucine; Leucine; Liver; Malondialdehyde; ortho-Aminobenzoates; Phenotype; Valine; Water Pollutants, Chemical; Zebrafish | 2022 |
NMR-Based Metabolomic Analysis of Cardiac Tissues Clarifies Molecular Mechanisms of CVB3-Induced Viral Myocarditis and Dilated Cardiomyopathy.
Topics: Alanine; Animals; Aspartic Acid; Biomarkers; Cardiomyopathy, Dilated; Coxsackievirus Infections; Enterovirus B, Human; Glutamic Acid; Glutamine; Glycine; Mice; Mice, Inbred BALB C; Myocarditis; Niacin; Niacinamide; Serine; Taurine; Threonine | 2022 |
[Mechanism of Cordyceps militaris against non-small cell lung cancer: based on serum metabolomics].
Topics: Alanine; Animals; Arginine; Aspartic Acid; Carcinoma, Non-Small-Cell Lung; Cisplatin; Cordyceps; Glutamic Acid; Glutamine; Glyoxylates; Humans; Lung Neoplasms; Metabolomics; Mice; Mice, Nude; Nitrogen; Phenylalanine; RNA, Transfer; Tryptophan; Tyrosine | 2022 |
Aberrant amino acid metabolism promotes neurovascular reactivity in rosacea.
Topics: Animals; Aspartic Acid; Doxycycline; Endothelial Cells; Glutamic Acid; Mice; Rosacea | 2022 |
Comparison of amino acid digestibility and its additivity determined with slaughter or cecectomy method for yellow-feather chicken.
Topics: Amino Acids; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Arginine; Aspartic Acid; Chickens; Diet; Digestion; Feathers; Glutamic Acid; Glycine; Glycine max; Histidine; Ileum; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Valine; Zea mays | 2022 |
A lysine residue from an extracellular turret switches the ion preference in a Cav3 T-Type channel from calcium to sodium ions.
Topics: Animals; Aspartic Acid; Calcium; Calcium Channels, T-Type; Glutamic Acid; Ions; Lymnaea; Lysine; Sodium | 2022 |
Deciphering the Alphabet of Disorder-Glu and Asp Act Differently on Local but Not Global Properties.
Topics: Aspartic Acid; Glutamic Acid; Intrinsically Disordered Proteins; Molecular Dynamics Simulation; Protein Conformation | 2022 |
Electrophoretic mobilization in capillary isoelectric focusing by a weak acid or an acidic ampholyte as catholyte assessed by computer simulation.
Topics: Acetates; Ampholyte Mixtures; Aspartic Acid; Capillary Isoelectric Focusing; Computer Simulation; Glutamic Acid; Hydrogen-Ion Concentration; Isoelectric Focusing | 2023 |
Topics: Aspartic Acid; Glutamic Acid; Humans; Isotopes; Melanoma; Zinc; Zinc Isotopes | 2022 |
Altered neurometabolite levels in the brains of patients with depression: A systematic analysis of magnetic resonance spectroscopy studies.
Topics: Aspartic Acid; Brain; Choline; Depression; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Proton Magnetic Resonance Spectroscopy; Reproducibility of Results | 2023 |
Subchronic tolerance trials of graded oral supplementation with ornithine hydrochloride or citrulline in healthy adults.
Topics: Adult; Arginine; Aspartic Acid; Citrulline; Dietary Supplements; Glutamic Acid; Humans; Male; Ornithine | 2023 |
Wild soybean salt tolerance metabolic model: Assessment of storage protein mobilization in cotyledons and C/N balance in the hypocotyl/root axis.
Topics: Asparagine; Aspartic Acid; Carbon; Cotyledon; Fabaceae; Gene Expression Regulation, Plant; Glutamic Acid; Glycine max; Hypocotyl; Nitrogen; Plant Proteins; Salt Tolerance | 2023 |
Longitudinal changes in brain metabolites in healthy controls and patients with first episode psychosis: a 7-Tesla MRS study.
Topics: Adult; Aspartic Acid; Brain; Glutamic Acid; Glutamine; Glutathione; Gyrus Cinguli; Humans; Psychotic Disorders; Young Adult | 2023 |
Progressive tremor and motor impairment in seizure-prone mutant tremor mice are associated with neurotransmitter dysfunction.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Mice; Motor Disorders; Neurotransmitter Agents; Norepinephrine; Seizures; Serotonin; Tremor | 2023 |
Bulk Biopolyelectrolyte Complexes from Homopolypeptides: Solid "Salt Bridges".
Topics: Amino Acids; Aspartic Acid; Glutamic Acid; Lysine; Peptides | 2023 |
Consistency of frontal cortex metabolites quantified by magnetic resonance spectroscopy within overlapping small and large voxels.
Topics: Aspartic Acid; Choline; Creatine; Frontal Lobe; Glutamic Acid; Glutamine; Inositol; Magnetic Resonance Spectroscopy; Proton Magnetic Resonance Spectroscopy | 2023 |
Brain metabolites measured with magnetic resonance spectroscopy in pediatric concussion and orthopedic injury: An Advancing Concussion Assessment in Pediatrics (A-CAP) study.
Topics: Adolescent; Aspartic Acid; Brain; Brain Concussion; Child; Choline; Creatine; Glutamic Acid; Humans; Inositol; Magnetic Resonance Spectroscopy | 2023 |
The Utility of Amino Acid Metabolites in the Diagnosis of Major Depressive Disorder and Correlations with Depression Severity.
Topics: Amino Acids; Aspartic Acid; Biomarkers; Depression; Depressive Disorder, Major; Glutamic Acid; Glycine; Humans; Phenylalanine | 2023 |
Ferrous sulfate reverses cerebral metabolic abnormality induced by minimal hepatic encephalopathy.
Topics: Animals; Arginine; Aspartic Acid; Brain; Glutamic Acid; Glycine; Hepatic Encephalopathy; Iron; Lactic Acid; Proline; Rats | 2023 |
Changes in brain metabolite levels across childhood.
Topics: Aspartic Acid; Brain; Child; Choline; Creatine; Cross-Sectional Studies; Glutamic Acid; Glutamine; Humans; Inositol; Receptors, Antigen, T-Cell | 2023 |
Efficient detection of L-aspartic acid and L-glutamic acid by self-assembled fluorescent microparticles with AIE and FRET activities.
Topics: Amino Acids; Animals; Aspartic Acid; Coloring Agents; Fluorescence Resonance Energy Transfer; Glutamic Acid; Peptides | 2023 |
Cytoplasmic amino acid profiles of clinical and ATCC 29213 strains of Staphylococcus aureus harvested at different growth phases.
Topics: Amino Acids; Aspartic Acid; Cytoplasm; Glutamic Acid; Humans; Staphylococcal Infections; Staphylococcus aureus | 2023 |
Chemoenzymatic and Synthetic Approaches To Investigate Aspartate- and Glutamate-ADP-Ribosylation.
Topics: Adenosine Diphosphate Ribose; ADP-Ribosylation; Aspartic Acid; Glutamic Acid; Histones; Peptides | 2023 |
Cerebrospinal fluid, brain, and spinal cord levels of L-aspartate signal excitatory neurotransmission abnormalities in multiple sclerosis patients and experimental autoimmune encephalomyelitis mouse model.
Topics: Animals; Aspartic Acid; Brain; Cytokines; D-Aspartic Acid; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino Acids; Glutamic Acid; Mice; Multiple Sclerosis; Spinal Cord; Synaptic Transmission | 2023 |
Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples.
Topics: Aspartic Acid; Carbon Isotopes; Citric Acid Cycle; Glutamic Acid; Humans; Mass Spectrometry | 2023 |
Stabilization of Synthetic Collagen Triple Helices: Charge Pairs and Covalent Capture.
Topics: Aspartic Acid; Collagen; Glutamic Acid; Lysine; Models, Molecular | 2023 |