aspartic acid has been researched along with dizocilpine maleate in 180 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 71 (39.44) | 18.7374 |
| 1990's | 68 (37.78) | 18.2507 |
| 2000's | 36 (20.00) | 29.6817 |
| 2010's | 5 (2.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Kurtz, HJ; Larson, AA; Skilling, SR; Sun, X | 1 |
| Dennis, JA; Dodd, PR; Gundlach, AL; Harper, PA; Healy, PJ; Johnston, GA; Williams, SH | 1 |
| Abarca, J; Bradberry, CW; Bustos, G; Forray, MI; Gysling, K; Roth, RH | 1 |
| Matsumoto, M; Scheller, MS; Strnat, MA; Zornow, MH | 1 |
| Coyle, JT; Tasker, RC; Vornov, JJ | 1 |
| Chizhmakov, IV; Jackson, H; Kiskin, NI; Krishtal, OA; Mueller, AL | 1 |
| Kuramoto, K; Nishimura, S; Sorimachi, M | 1 |
| Carter, AJ; Müller, RE | 1 |
| Albuquerque, EX; Alkondon, M; Aronstam, RS; Costa, AC; Radhakrishnan, V | 1 |
| Carlsson, A; Carlsson, M | 1 |
| Bartlett, MC; MacDonald, JF; Mody, I; Pahapill, P; Pennefather, PS; Reynolds, JN; Salter, MW; Schneiderman, JH | 1 |
| Nicklas, WJ; Zeevalk, GD | 2 |
| Bommarito, M; Johnston, MV; McDonald, JW; Silverstein, FS | 1 |
| Anderson, EG; Grigg, JJ | 1 |
| Akaike, N; Murase, K; Nakagawa, T; Shirasaki, T; Tateishi, N | 1 |
| Miyamoto, T; Okada, Y; Sakurai, T | 1 |
| Hestrin, S; Nicoll, RA; Sah, P | 1 |
| Fink, K; Göthert, M; Schlicker, E | 1 |
| Bockaert, J; Didier, M; Heaulme, M; Pin, JP; Soubrié, P | 1 |
| Carboni, S; Hadjiconstantinou, M; Melis, F; Pani, L; Rossetti, ZL | 1 |
| Keith, R; Patel, J; Salama, A; Thompson, C; Zinkand, WC | 1 |
| Mehta, AK; Ticku, MK | 1 |
| Girault, JA; Greengard, P; Halpain, S | 1 |
| Costa, E; Eimerl, S; Schramm, M | 1 |
| Britcher, SF; Denny, GH; Kemp, JA; Knight, AR; Lyle, TA; Magill, CA; Marshall, GR; Middlemiss, DN; Murphy, JS; Thompson, WJ | 1 |
| Keana, JF; Parker, JD; Quarum, ML; Weber, E | 1 |
| Kozikowski, AP; Pang, YP | 1 |
| Meldrum, BS; Swan, JH | 1 |
| Cline, HT; Constantine-Paton, M | 2 |
| Kesingland, AC; Singh, L; Tricklebank, MD; Wong, EH | 1 |
| Carlsson, M; Svensson, A | 1 |
| Di Chiara, G; Morelli, M | 1 |
| Bourguignon, JP; Franchimont, P; Gerard, A; Mathieu, A; Mathieu, J | 1 |
| Courtney, MJ; Lambert, JJ; Nicholls, DG | 1 |
| Akita, K; Ino, H; Kudo, Y; Mikoshiba, K; Miyawaki, A; Ogura, A; Yuzaki, M | 1 |
| Faden, AI; Yum, SW | 1 |
| Labruyere, J; Olney, JW; Price, MT; Zorumski, C | 1 |
| Abraham, WC; Mason, SE; Ward, L | 1 |
| Daniell, LC | 1 |
| Ogita, K; Suzuki, T; Yoneda, Y | 1 |
| Gilbert, ME; Mack, CM | 1 |
| Hansen, AJ; Lauritzen, M; Wieloch, T; Zhang, ET | 1 |
| Buchan, A; Pulsinelli, WA | 1 |
| Kulkarni, SK; Mehta, AK; Ticku, MK | 1 |
| Bean, BP; Huettner, JE | 1 |
| Rothman, S | 1 |
| DeLander, GE; Wahl, JJ | 1 |
| Ahier, RG; Middlemiss, DN; Price, GW; Singh, L; Tricklebank, MD; Wong, EH | 1 |
| Abraham, WC; Kirk, RC; McNaughton, N; Tan, S | 1 |
| Harris, KM; Miller, RJ; Reynolds, IJ | 1 |
| Deschenes, NL; Ransom, RW | 1 |
| Balster, RL; Willetts, J | 2 |
| Buerki, H; Fagg, GE; Mondadori, C; Petschke, F; Weiskrantz, L | 1 |
| Rogers, BC; Tilson, HA | 1 |
| Bourguignon, JP; Franchimont, P; Gerard, A; Mathieu, J; Simons, J | 1 |
| Cler, J; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Wood, PL | 1 |
| Ciliax, BJ; Gildersleeve, D; Pirat, JL; Van Dort, ME; Wieland, DM; Yang, DJ; Young, AB | 1 |
| Balázs, R; Cotman, CW; Hack, N; Jørgensen, OS | 1 |
| Iversen, SD; Oles, RJ; Preston, C; Singh, L; Tricklebank, MD | 1 |
| Herberg, LJ; Rose, IC | 1 |
| Hillman, CC; Ornstein, PL; Salhoff, CR; Schoepp, DD | 1 |
| Jope, RS; Ormandy, GC; Snead, OC | 1 |
| Janssen, PA; Leysen, JE; Pauwels, PJ; Van Assouw, HP | 1 |
| Molinoff, PB; Romano, C; Williams, K | 1 |
| Miller, RJ; Reynolds, IJ | 1 |
| Chambers, G; Cottrell, JE; Kass, IS | 1 |
| Brewer, GJ; Cotman, CW | 1 |
| Anderson, WW; Clark, S; Stasheff, SF; Wilson, WA | 1 |
| Davidoff, RA; Hackman, JC; Zhang, DX | 1 |
| Porter, RJ | 1 |
| Keith, RA; Klika, AB; Mangano, TJ; Meiners, BA; Patel, J; Salama, AI; Stumpo, RJ | 1 |
| Sawyer, BD; Shannon, HE | 1 |
| Halliwell, RF; Lambert, JJ; Peters, JA | 1 |
| Jackson, A; Sanger, DJ | 1 |
| France, CP; Ornstein, P; Woods, JH | 1 |
| Aryanpur, JJ; Cole, AE; Eccles, CU; Fisher, RS | 1 |
| Cotman, CW; Neal, JH; Peterson, C | 1 |
| McCulloch, J; Nehls, DG; Park, CK; Teasdale, GM | 1 |
| Desban, M; Gauchy, C; Glowinski, J; Kemel, ML; Krebs, MO | 1 |
| Johnston, MV; McDonald, JW; Roeser, NF; Silverstein, FS | 1 |
| Boyce, S; Crossman, AR; Luquin, MR; Peggs, D; Sambrook, MA | 1 |
| Igarashi, H; Kamei, J; Kasuya, Y; Tanihara, H | 1 |
| Butelman, ER | 1 |
| Darlington, CL; Smith, PF | 2 |
| Aram, JA; Church, J; Davies, SN; Lodge, D; Martin, D; Millar, JD | 1 |
| Champagnat, J; Denavit-Saubié, M; Foutz, AS | 2 |
| Choi, DW; Goldberg, MP; Viseskul, V | 1 |
| Koek, W; Winger, GD; Woods, JH | 1 |
| Faden, AI; Simon, RP | 1 |
| Aizenman, E; Karschin, A; Lipton, SA | 1 |
| Lalies, M; Middlemiss, DN; Ransom, R | 1 |
| Schmidt, CJ; Taylor, VL | 1 |
| Ciliax, BJ; Gildersleeve, DL; Kilbourn, MR; Laborde, E; Pirat, JL; Van Dort, ME; Wieland, DM; Yang, DJ; Young, AB | 1 |
| De Prins, E; Marrannes, R; Wauquier, A; Willems, R | 1 |
| Foster, AC; Wong, EH | 1 |
| Childs, AM; Evans, RH; Watkins, JC | 1 |
| Connick, JH; Stone, TW | 1 |
| Aizenman, E; Hahn, JS; Lipton, SA | 1 |
| Graham, DI; McCulloch, J; Nehls, DG; Park, CK; Teasdale, GM | 1 |
| Foster, AC; Gill, R; Woodruff, GN | 1 |
| Ho, PM; Tang, AH | 1 |
| Borosky, SA; Clissold, DB; Ferkany, JW; Pontecorvo, MJ | 1 |
| Faden, AI; Lemke, M; Noble, LJ; Simon, RP | 1 |
| Johnson, KM; Snell, LD; Yi, SJ | 1 |
| Ransom, RW; Stec, NL | 1 |
| Bowery, NG; Hudson, AL; Wong, EH | 1 |
| Prasad, SK; Salt, TE; Wilson, DG | 1 |
| Foster, AC; Gill, R; Kemp, JA; Woodruff, GN | 1 |
| Frierdich, G; Labruyere, J; Olney, J; Price, M; Salles, KS | 1 |
| Iversen, LL; Kemp, JA; Knight, AR; Priestley, T; Wong, EH; Woodruff, GN | 1 |
| Mikuni, M; Saitoh, K; Shinno, H; Takahashi, K; Tomita, U; Yamawaki, S | 1 |
| Boulu, RG; Callebert, J; Ghribi, O; Plotkine, M; Verrecchia, C | 1 |
| Agostinho, P; Carvalho, AP; Duarte, CB; Oliveira, CR | 1 |
| Beal, MF; Brouillet, E; Henshaw, DR; Schulz, JB | 1 |
| López-Colomé, AM; Ortega, A; Romo-de-Vivar, M | 1 |
| Ciani, E; Contestabile, A; Dall'Olio, R; Facchinetti, F; Sparapani, M; Virgili, M | 1 |
| Beloeil, JC; Borredon, J; Correze, JL; Gillet, B; Jacques, S; Lhoste, JM; Loubinoux, I; Meric, P; Mispelter, J; Tiffon, B | 1 |
| Fedele, E; Foster, AC | 1 |
| LaPlaca, MC; Lenkinski, RE; Rubin, Y; Smith, DH; Thibault, LE | 1 |
| Gyte, A; Lock, EA; Simpson, MG; Widdowson, PS; Wyatt, I | 1 |
| Davies, JA; Richens, A; Srinivasan, J | 1 |
| Carter, C; Fage, D; Klarica, M | 1 |
| Fonnum, F; Mathisen, GA; Paulsen, RE | 1 |
| Araki, T; Fujiwara, T; Itoyama, Y; Kato, H; Nagaki, S; Shuto, K | 1 |
| Araki, T; Chen, T; Hiranuma, T; Itoyama, Y; Kato, H; Kogure, K; Liu, XH; Murase, K | 1 |
| Dorandeu, F; Fosbraey, P; Lallement, G; Pernot-Marino, I; Tattersall, JE; Wetherell, J | 1 |
| Bigelow, LB; Herman, MM; Hyde, TM; Kleinman, JE; Noga, JT; Spurney, CF; Weinberger, DR | 1 |
| Ciani, E; Contestabile, A; Dall'Olio, R; Gandolfi, O; Sparapani, M | 1 |
| Nicholls, DG; Pocock, JM | 1 |
| de Mello, FG; de Mello, MC; Kubrusly, RC | 1 |
| Besselsen, E; Breukel, AI; Ghijsen, WE; Lopes da Silva, FH | 1 |
| Juhász, G; Kardos, J; Kékesi, KA; Kovács, I; Nyitrai, G; Szárics, E | 1 |
| Abarca, J; Bustos, G | 1 |
| Baca, SM; Hyde, TM; Jaskiw, GE; Kleinman, JE; Murray, AM; Spurney, CF | 1 |
| Chang, C; Lee, WT; Shen, YZ | 1 |
| Kardos, J; Kovács, I; Skuban, N; Szárics, E | 1 |
| Tobinaga, S | 1 |
| Aguilar-Veiga, E; Galán-Valiente, J; Sierra-Marcuño, G; Sierra-Paredes, G; Vazquez-Illanes, MD | 1 |
| Abarca, C; Contreras, E; Oliva, P; Sepúlveda, MJ; Silva, E | 1 |
| Abrahám, I; Harkany, T; Kónya, C; Korf, J; Laskay, G; Luiten, PG; Nyakas, C; Penke, B; Sasvári, M; Sebens, JB; Soós, K; Timmerman, W; Tóth, B; Zarándi, M | 1 |
| Cho, Y; Inoue, Y; Kawada, S; Mori, A; Nakamichi, T; Shimizu, H; Ueda, T | 1 |
| Bachelard, HS; Lock, EA; Williams, RE | 1 |
| Chen, JC; Chiang, YC; Huang, YK; Liang, CS; Liang, KW | 1 |
| Ichord, RN; Johnston, MV; Traystman, RJ | 1 |
| Andersson, K; Chen, Y; Dell'Anna, E; Engidawork, E; Goiny, M; Gross, J; Herrera-Marschitz, M; Kohlhauser, C; Loidl, F; Lubec, B; Lubec, G; Stoeckler, S | 1 |
| Dohovics, R; Hermann, A; Janáky, R; Oja, SS; Saransaari, P | 1 |
| Arnth-Jensen, N; Jabaudon, D; Scanziani, M | 1 |
| Bachelard, HS; Badar-Goffer, RS; Ben-Yoseph, O; McLean, MA; Morris, PG; Prior, MJ; Taylor, A; Thatcher, NM | 1 |
| Bashkatova, V; Kraus, MM; Philippu, A; Prast, H; Vanin, A | 1 |
| Himi, T; Ikeda, M; Murota, SI; Yasuhara, T | 1 |
| Griffith, LC; Nelson, SB; Pratt, KG; Turrigiano, GG; Watt, AJ | 1 |
| Ahmed, Z; Baker, D; Croxford, JL; Cuzner, ML; Giovannoni, G; Hankey, DJ; Jackson, SJ; Ledent, C; Petzold, A; Pocock, JM; Pryce, G; Thompson, AJ | 1 |
| Cho, Y; Mori, A; Shimizu, H; Ueda, T; Yozu, R | 1 |
| Chang, YC; Cherng, CH; Tao, PL; Wang, JJ; Wen, ZH; Wong, CS | 1 |
| Argiolas, A; Cortis, L; Mascia, MS; Melis, MR; Succu, S | 1 |
| Grebenyuk, S; Kirichok, Y; Krishtal, O; Lozovaya, N; Melnik, S; Tsintsadze, T | 1 |
| Auberson, YP; Bashir, ZI; Brown, MW; Collingridge, GL; Johnson, BE; Massey, PV; Molnar, E; Moult, PR | 1 |
| Babot, Z; Cristòfol, R; Suñol, C | 1 |
| Boeck, CR; Bronzatto, MJ; Jardim, FM; Kroth, EH; Souza, DO; Vendite, D | 1 |
| Dunlop, J; Foster, AC; Mackay, KB; Moyer, J; Naeve, GS; Nottebaum, LM; Petroski, RE; Pomeroy, JE; Selkirk, JV; Stiefel, TH; Vana, AM; Verge, GM | 1 |
| Brenner, E; Håberg, A; Kondziella, D; Sonnewald, U | 1 |
| Bersier, MG; Miksztowicz, V; Peña, C; Rodríguez de Lores Arnaiz, G | 1 |
| Bonde, C; Noer, H; Noraberg, J; Zimmer, J | 1 |
| Fonnum, F; Mariussen, E; Reistad, T; Ring, A | 1 |
| Kettenmann, H; Kirischuk, S; Verkhratsky, A | 1 |
| Beani, L; Marani, L; Marino, S; Nazzaro, C; Siniscalchi, A | 1 |
| Bai, JZ; Donnelly, D; Li, D; Lipski, J; Pi, R; Wan, CK | 1 |
| Anwyl, R; Harney, SC; Jane, DE | 1 |
| Abarca, J; Bustos, G; Bustos, V; Campusano, J; Moya, C; Noriega, V; Riquelme, E | 1 |
| Blau, C; Fagan, AJ; Harte, M; Harvey, RP; Kerskens, C; Lai, D; O'Leary, C; O'Sullivan, GJ; O'Tuathaigh, CM; Reynolds, GP; Tighe, O; Waddington, JL | 1 |
| Briz, V; Suñol, C | 1 |
| Chowdhury, VS; Erwan, E; Furuse, M; Goda, R; Nagasawa, M; Otsuka, T; Yasuo, S | 1 |
| Bollands, M; Jones, S; Morris, PG; Wild, AR | 1 |
| Aylsworth, A; Blondeau, N; Brunette, E; Hewitt, M; Tauskela, JS | 1 |
1 review(s) available for aspartic acid and dizocilpine maleate
| Article | Year |
|---|---|
Interactions between glutamatergic and monoaminergic systems within the basal ganglia--implications for schizophrenia and Parkinson's disease.
Topics: Animals; Anticonvulsants; Aspartic Acid; Basal Ganglia; Biogenic Amines; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Humans; N-Methylaspartate; Parkinson Disease; Schizophrenia | 1990 |
179 other study(ies) available for aspartic acid and dizocilpine maleate
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Selective potentiation of NMDA-induced activity and release of excitatory amino acids by dynorphin: possible roles in paralysis and neurotoxicity.
Topics: Animals; Aspartic Acid; Behavior, Animal; Cell Death; Dizocilpine Maleate; Dynorphins; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurons; Paralysis; Rats; Rats, Inbred Strains; Spinal Cord | 1992 |
Glutamate and gamma-aminobutyric acid neurotransmitter systems in the acute phase of maple syrup urine disease and citrullinemia encephalopathies in newborn calves.
Topics: Acute-Phase Reaction; Animals; Animals, Newborn; Aspartic Acid; Brain Diseases; Cattle; Cattle Diseases; Cerebral Cortex; Citrulline; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Glutamates; Male; Maple Syrup Urine Disease; Neurotransmitter Agents; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1992 |
Regulation of excitatory amino acid release by N-methyl-D-aspartate receptors in rat striatum: in vivo microdialysis studies.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Extracellular Space; Fluorometry; Glutamates; Glutamic Acid; Kynurenic Acid; Male; N-Methylaspartate; Perfusion; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serine | 1992 |
AMPA and NMDA receptor antagonists do not decrease hippocampal glutamate concentrations during transient global ischemia.
Topics: Animals; Aspartic Acid; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Ischemic Attack, Transient; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reperfusion | 1992 |
The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801.
Topics: Animals; Aspartic Acid; Culture Techniques; Deoxyglucose; Dizocilpine Maleate; Glucose; Glutamates; Glutamic Acid; Hippocampus; Histological Techniques; Hypoglycemia; N-Methylaspartate; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Time Factors | 1992 |
A highly potent and selective N-methyl-D-aspartate receptor antagonist from the venom of the Agelenopsis aperta spider.
Topics: Agatoxins; Animals; Aspartic Acid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Neurotoxins; Polyamines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spiders | 1992 |
Receptor types mediating the rise in the cytosolic free calcium concentration by L-aspartate and L-glutamate in immature cerebellar neurons with N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Calcium; Cerebellum; Cytosol; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kinetics; Magnesium; Neurons; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Activation of excitatory amino acid receptors cannot alone account for anoxia-induced impairment of protein synthesis in rat hippocampal slices.
Topics: Animals; Aspartic Acid; Carbon Radioisotopes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; Hypoxia; Kainic Acid; Lysine; Male; N-Methylaspartate; Nerve Tissue Proteins; Phenazocine; Phencyclidine; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1991 |
Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead.
Topics: Animals; Aspartic Acid; Calcium; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Conductivity; Glycine; Hippocampus; Ion Channels; Kainic Acid; Lead; Learning Disabilities; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Actions of ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampal neurones.
Topics: Animals; Aspartic Acid; Culture Techniques; Dizocilpine Maleate; Hippocampus; Ion Channel Gating; Ketamine; Mice; Mice, Inbred Strains; Neurons; Phencyclidine; Receptors, N-Methyl-D-Aspartate | 1991 |
Mechanisms underlying initiation of excitotoxicity associated with metabolic inhibition.
Topics: Animals; Aspartic Acid; Chick Embryo; Dizocilpine Maleate; Extracellular Space; gamma-Aminobutyric Acid; Glutamates; Glycolysis; Iodoacetates; Iodoacetic Acid; Membrane Potentials; Potassium; Potassium Cyanide; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1991 |
Effects of hypoxia-ischemia and MK-801 treatment on the binding of a phencyclidine analogue in the developing rat brain.
Topics: Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hypoxia; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Tritium | 1990 |
Competitive and noncompetitive N-methyl-D-aspartate antagonists modify hypoxia-induced membrane potential changes and protect rat hippocampal slices from functional failure: a quantitative comparison.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Cell Hypoxia; Cell Survival; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1990 |
Effects of antagonists on N-methyl-D-aspartate response in acutely isolated nucleus tractus solitarii neurons of the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Medulla Oblongata; N-Methylaspartate; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Masking effect of NMDA receptor antagonists on the formation of long-term potentiation (LTP) in superior colliculus slices from the guinea pig.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Denervation; Dibenzocycloheptenes; Dipeptides; Dizocilpine Maleate; Evoked Potentials; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; Magnesium; Mice; Nerve Degeneration; Optic Nerve; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Superior Colliculi; Visual Cortex | 1990 |
Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Ketamine; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Temperature; Time Factors | 1990 |
Veratridine and other depolarizing agents counteract the inhibitory effect of Mg2+ ions on N-methyl-D-aspartate (NMDA)-induced noradrenaline release in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Amifampridine; Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Stimulation; Hydrogen; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Veratridine; Veratrine | 1990 |
Rapid, sensitive, and simple method for quantification of both neurotoxic and neurotrophic effects of NMDA on cultured cerebellar granule cells.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; Culture Media; Dizocilpine Maleate; Glutamates; Glutamic Acid; Mice; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Potassium | 1990 |
The non-competitive NMDA-receptor antagonist MK-801 prevents the massive release of glutamate and aspartate from rat striatum induced by 1-methyl-4-phenylpyridinium (MPP+).
Topics: 1-Methyl-4-phenylpyridinium; Animals; Aspartic Acid; Corpus Striatum; Dizocilpine Maleate; Dopamine; Glutamates; Glutamic Acid; Kinetics; Male; Rats; Rats, Inbred Strains | 1990 |
Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Serine | 1990 |
Role of N-methyl-D-aspartate (NMDA) receptors in experimental catalepsy in rats.
Topics: Animals; Aspartic Acid; Baclofen; Bromocriptine; Catalepsy; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Interactions; Haloperidol; Male; N-Methylaspartate; Nimodipine; Nitrendipine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Scopolamine | 1990 |
Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices.
Topics: Animals; Aspartic Acid; Calcineurin; Calmodulin-Binding Proteins; Colforsin; Corpus Striatum; Cyclic AMP; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Activation; N-Methylaspartate; Nerve Tissue Proteins; Phosphates; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphothreonine; Protein Kinases; Protein Phosphatase 1; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1990 |
Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: role of the glutamate receptor responsive to N-methyl-D-aspartate.
Topics: Animals; Anticonvulsants; Aspartic Acid; Blood; Cell Survival; Cells, Cultured; Cerebellum; Culture Media; Cytoplasmic Granules; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Piperazines; Potassium Chloride; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Veratridine | 1990 |
Structure and activity of hydrogenated derivatives of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801).
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Molecular Conformation; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1990 |
(+)-[3H]MK-801 binding sites in postmortem human brain.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Female; Humans; Male; Middle Aged; N-Methylaspartate; Postmortem Changes; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereoisomerism; Tissue Distribution; Tritium | 1990 |
Structural determinants of affinity for the phencyclidine binding site of the N-methyl-D-aspartate receptor complex: discovery of a rigid phencyclidine analogue of high binding affinity.
Topics: Animals; Aspartic Acid; Computer Graphics; Crystallography; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Models, Molecular; Molecular Conformation; Molecular Structure; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; X-Ray Diffraction | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
NMDA receptor agonist and antagonists alter retinal ganglion cell arbor structure in the developing frog retinotectal projection.
Topics: Animals; Aspartic Acid; Dendrites; Dibenzocycloheptenes; Dizocilpine Maleate; Larva; N-Methylaspartate; Rana pipiens; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells; Superior Colliculi; Synaptic Transmission | 1990 |
Evidence against an involvement of the haloperidol-sensitive sigma recognition site in the discriminative stimulus properties of (+)-N-allylnormetazocine ((+)-SKF 10,047).
Topics: Animals; Aspartic Acid; Binding, Competitive; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Guanidines; Haloperidol; Male; Mice; N-Methylaspartate; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Seizures | 1990 |
Interfering with glutamatergic neurotransmission by means of NMDA antagonist administration discloses the locomotor stimulatory potential of other transmitter systems.
Topics: Animals; Aspartic Acid; Atropine; Biogenic Monoamines; Clonidine; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Glutamates; Ketamine; Male; Mice; Motor Activity; N-Methylaspartate; Rats; Rats, Inbred Strains; Synaptic Transmission | 1990 |
Stereospecific blockade of N-methyl-D-aspartate transmission by MK 801 prevents priming of SKF 38393-induced turning.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hydroxydopamines; Male; N-Methylaspartate; Oxidopamine; Rats; Rats, Inbred Strains; Stereoisomerism; Stereotyped Behavior; Sympathectomy, Chemical; Synaptic Transmission | 1990 |
Maturation of the hypothalamic control of pulsatile gonadotropin-releasing hormone secretion at onset of puberty. I. Increased activation of N-methyl-D-aspartate receptors.
Topics: Aging; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Gonadotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Hypothalamus; Kinetics; Magnesium; Male; N-Methylaspartate; Organ Culture Techniques; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sexual Maturation; Spermatids; Testis | 1990 |
Glutamate-receptor-mediated regulation of the cytoplasmic free calcium level in cultured cerebellar granule cells.
Topics: Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Cytoplasm; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamates; Glycine; Kainic Acid; Magnesium; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Mode of blockade by MK-801 of N-methyl-D-aspartate-induced increase in intracellular Ca2+ in cultured mouse hippocampal neurons.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; Mice; Mice, Inbred ICR; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Temperature | 1990 |
Comparison of the neuroprotective effects of the N-methyl-D-aspartate antagonist MK-801 and the opiate-receptor antagonist nalmefene in experimental spinal cord ischemia.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Humans; Ischemia; Male; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Rabbits; Spinal Cord; Time Factors | 1990 |
L-cysteine, a bicarbonate-sensitive endogenous excitotoxin.
Topics: Animals; Animals, Newborn; Anticonvulsants; Aspartic Acid; Bicarbonates; Caudate Nucleus; Chick Embryo; Cysteine; Dibenzocycloheptenes; Dizocilpine Maleate; N-Methylaspartate; Necrosis; Neurons; Neurotoxins; Rats; Rats, Inbred Strains; Retina; Retinal Ganglion Cells; Zinc | 1990 |
Effects of the NMDA antagonists CPP and MK-801 on radial arm maze performance in rats.
Topics: Animals; Aspartic Acid; Behavior, Animal; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Memory; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Single-Blind Method | 1990 |
The noncompetitive N-methyl-D-aspartate antagonists, MK-801, phencyclidine and ketamine, increase the potency of general anesthetics.
Topics: Anesthesia, General; Anesthetics; Animals; Aspartic Acid; Behavior, Animal; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Ketamine; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Phencyclidine | 1990 |
Interaction of strychnine-insensitive glycine binding with MK-801 binding in brain synaptic membranes.
Topics: Animals; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Interactions; Glycine; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Spinal Cord; Stereoisomerism; Strychnine; Synaptic Membranes | 1990 |
The NMDA antagonist, MK-801, suppresses long-term potentiation, kindling, and kindling-induced potentiation in the perforant path of the unanesthetized rat.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Stimulation; Evoked Potentials; Kindling, Neurologic; Male; N-Methylaspartate; Rats; Reference Values; Synapses | 1990 |
Influence of MK-801 on brain extracellular calcium and potassium activities in severe hypoglycemia.
Topics: Animals; Aspartic Acid; Blood Glucose; Blood Pressure; Brain; Calcium; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Electrophysiology; Extracellular Space; Hypoglycemia; Male; N-Methylaspartate; Potassium; Rats; Rats, Inbred Strains | 1990 |
Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia.
Topics: Animals; Aspartic Acid; Body Temperature; Dibenzocycloheptenes; Dizocilpine Maleate; Female; Gerbillinae; Hypothermia, Induced; Ischemic Attack, Transient; N-Methylaspartate; Neurons | 1990 |
Comparison of anticonvulsant effect of ethanol against NMDA-, kainic acid- and picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Ethanol; Kainic Acid; Male; N-Methylaspartate; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1990 |
Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.
Topics: Action Potentials; Animals; Anticonvulsants; Aspartic Acid; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Ion Channels; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Visual Cortex | 1988 |
Noncompetitive N-methyl-D-aspartate antagonists affect multiple ionic currents.
Topics: Action Potentials; Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; Ion Channels; Ketamine; N-Methylaspartate; Phencyclidine; Potassium; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1988 |
In vivo characterization of phencyclidine/sigma agonist-mediated inhibition of nociception.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Binding, Competitive; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Mice; N-Methylaspartate; Nociceptors; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, Opioid, delta; Substance P | 1989 |
In vivo labelling of the NMDA receptor channel complex by [3H]MK-801.
Topics: Affinity Labels; Animals; Anticonvulsants; Aspartic Acid; Binding Sites; Binding, Competitive; Dibenzocycloheptenes; Dioxolanes; Dizocilpine Maleate; Ion Channels; Male; Mice; N-Methylaspartate; Phenazocine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1988 |
Effects of the NMDA antagonists CPP and MK-801 on delayed conditional discrimination.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1989 |
NMDA receptor antagonists that bind to the strychnine-insensitive glycine site and inhibit NMDA-induced Ca2+ fluxes and [3H]GABA release.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Calcium; Desipramine; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Ketamine; Kynurenine; Membranes; N-Methylaspartate; Piperazines; Pyrrolidinones; Radioligand Assay; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
Glycine modulation of NMDA-evoked release of [3H]acetylcholine and [3H]dopamine from rat striatal slices.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Glycine; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1989 |
Pentobarbital-like discriminative stimulus effects of N-methyl-D-aspartate antagonists.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flumazenil; Generalization, Psychological; Male; N-Methylaspartate; Pentobarbital; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
NMDA receptor antagonists can enhance or impair learning performance in animals.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Gerbillinae; Male; Memory; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
MK-801 prevents cognitive and behavioral deficits produced by NMDA receptor overstimulation in the rat hippocampus.
Topics: Animals; Aspartic Acid; Behavior, Animal; Cognition Disorders; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; Male; N-Methylaspartate; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Pulsatile release of gonadotropin-releasing hormone from hypothalamic explants is restrained by blockade of N-methyl-D,L-aspartate receptors.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hypothalamus; Kainic Acid; Magnesium; Male; N-Methylaspartate; Pituitary Hormone-Releasing Hormones; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
In vivo modulation of the N-methyl-D-aspartate receptor complex by D-serine: potentiation of ongoing neuronal activity as evidenced by increased cerebellar cyclic GMP.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Cycloserine; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Mice; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1989 |
Synthesis and receptor binding studies of (+/-)1-iodo-MK-801.
Topics: Animals; Anticonvulsants; Aspartic Acid; Autoradiography; Brain Chemistry; Dibenzocycloheptenes; Dizocilpine Maleate; Iodine Radioisotopes; Isotope Labeling; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebellum; Dextromethorphan; Dibenzocycloheptenes; Dizocilpine Maleate; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Binding, Competitive; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ketamine; Male; Motor Activity; N-Methylaspartate; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1989 |
The effect of MK-801 and other antagonists of NMDA-type glutamate receptors on brain-stimulation reward.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ketamine; Kynurenic Acid; Male; N-Methylaspartate; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Self Stimulation | 1989 |
CGS-19755 and MK-801 selectively prevent rat striatal cholinergic and gabaergic neuronal degeneration induced by N-methyl-D-aspartate and ibotenate in vivo.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Cholinergic Fibers; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Ibotenic Acid; Male; N-Methylaspartate; Nerve Degeneration; Oxazoles; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Hippocampus; Lithium; Male; N-Methylaspartate; Pilocarpine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Status Epilepticus | 1989 |
Effects of competitive and noncompetitive N-methyl-D-aspartate (NMDA) antagonists in rats trained to discriminate NMDA from saline.
Topics: Amino Acids; Animals; Aspartic Acid; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; N-Methylaspartate; Phenazocine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Ca2+-mediated neuronal death in rat brain neuronal cultures by veratridine: protection by flunarizine.
Topics: Animals; Aspartic Acid; Calcium; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flunarizine; Glutamates; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Rats; Sodium Channels; Tetrodotoxin; Veratridine; Veratrine | 1989 |
Effects of polyamines on the binding of [3H]MK-801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site.
Topics: Animals; Aspartic Acid; Binding Sites; Brain; Cattle; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; In Vitro Techniques; N-Methylaspartate; Polyamines; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1989 |
Acute excitotoxicity in chick retina caused by the unusual amino acids BOAA and BMAA: effects of MK-801 and kynurenate.
Topics: Amino Acids, Diamino; Animals; Aspartic Acid; beta-Alanine; Chick Embryo; Cyanobacteria Toxins; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamates; Histocytochemistry; Kynurenic Acid; N-Methylaspartate; Neurons; Neurotoxins; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina | 1989 |
Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines.
Topics: Acetamides; Animals; Aspartic Acid; Brain; Calcium; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glycine; In Vitro Techniques; Ketamine; Kinetics; N-Methylaspartate; Phencyclidine; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Evoked Potentials; Hippocampus; Hypoxia; In Vitro Techniques; Male; N-Methylaspartate; Neurotoxins; Pyramidal Tracts; Rats; Rats, Inbred Strains; Valine | 1989 |
NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons.
Topics: Animals; Animals, Newborn; Anticonvulsants; Aspartic Acid; Cells, Cultured; Culture Media; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Valine | 1989 |
NMDA antagonists and potentiation of NMDA-induced motoneuron depolarizations in the isolated frog spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Evoked Potentials; Ketamine; Kynurenic Acid; Magnesium; Motor Neurons; N-Methylaspartate; Potassium; Rana pipiens; Spinal Cord; Valine | 1989 |
Mechanisms of action of new antiepileptic drugs.
Topics: Acetamides; Acetates; Amines; Aminocaproates; Aminopyridines; Anti-Anxiety Agents; Anticonvulsants; Aspartic Acid; Benzodiazepines; Benzodiazepinones; Clobazam; Cyclohexanecarboxylic Acids; Dibenzocycloheptenes; Dizocilpine Maleate; Epilepsy; Felbamate; Flumazenil; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Imidazoles; Lamotrigine; Phenylcarbamates; Propylene Glycols; Receptors, GABA-A; Triazines; Vigabatrin | 1989 |
HA-966 acts at a modulatory glycine site to inhibit N-methyl-D-aspartate-evoked neurotransmitter release.
Topics: Animals; Aspartic Acid; Binding Sites; Dibenzocycloheptenes; Dizocilpine Maleate; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Piperazines; Pyrrolidinones; Rats; Strychnine | 1989 |
Glutamate receptors of the N-methyl-D-aspartate subtype in the myenteric plexus of the guinea pig ileum.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Guinea Pigs; Ileum; Magnesium; Male; Muscle Contraction; Myenteric Plexus; N-Methylaspartate; Piperazines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
NMDA receptor antagonists disrupt the retinotectal topographic map.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anura; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells; Superior Colliculi | 1989 |
The mechanism of action and pharmacological specificity of the anticonvulsant NMDA antagonist MK-801: a voltage clamp study on neuronal cells in culture.
Topics: Acetylcholine; Animals; Anticonvulsants; Aspartic Acid; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Stimulation; Evoked Potentials; Hippocampus; Ketamine; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1989 |
Effects of phencyclidine and other N-methyl-D-aspartate antagonists on the schedule-controlled behavior of rats.
Topics: Animals; Aspartic Acid; Conditioning, Psychological; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Piperazines; Piperidines; Punishment; Rats; Rats, Inbred Strains; Reinforcement Schedule; Stereoisomerism | 1989 |
The competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 attenuates the rate-decreasing effects of NMDA in rhesus monkeys without producing ketamine-like discriminative stimulus effects.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Ketamine; Macaca mulatta; Male; N-Methylaspartate; Pipecolic Acids; Piperidines | 1989 |
Selective depression of N-methyl-D-aspartate-mediated responses by dextrorphan in the hippocampal slice in rat.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dextrorphan; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Evoked Potentials; Hippocampus; In Vitro Techniques; Magnesium; Male; Morphinans; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains | 1989 |
Development of N-methyl-D-aspartate excitotoxicity in cultured hippocampal neurons.
Topics: Age Factors; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Embryo, Mammalian; Hippocampus; N-Methylaspartate; Neurotoxins; Rats; Rats, Inbred Strains | 1989 |
Effect of the NMDA antagonist MK-801 on local cerebral blood flow in focal cerebral ischaemia in the rat.
Topics: Animals; Aspartic Acid; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Rats; Rats, Inbred Strains | 1989 |
Glycine potentiates the NMDA-induced release of dopamine through a strychnine-insensitive site in the rat striatum.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Drug Synergism; Glycine; In Vitro Techniques; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Strychnine | 1989 |
Quantitative assessment of neuroprotection against NMDA-induced brain injury.
Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Choline O-Acetyltransferase; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Ketamine; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Regression Analysis | 1989 |
Effect of the NMDA antagonist MK-801 on MPTP-induced parkinsonism in the monkey.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Injections, Intramuscular; Levodopa; Macaca fascicularis; Male; MPTP Poisoning; N-Methylaspartate; Parkinson Disease, Secondary | 1989 |
Effects of N-methyl-D-aspartate antagonists on the cough reflex.
Topics: Animals; Anticonvulsants; Aspartic Acid; Capsaicin; Cough; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Reflex | 1989 |
A novel NMDA antagonist, MK-801, impairs performance in a hippocampal-dependent spatial learning task.
Topics: Animals; Aspartic Acid; Behavior, Animal; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraperitoneal; Learning; Male; Memory; Motor Activity; N-Methylaspartate; Rats | 1989 |
The effects of N-methyl-D-aspartate antagonists on the development of vestibular compensation in the guinea pig.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Ear, Inner; Guinea Pigs; In Vitro Techniques; N-Methylaspartate; Nystagmus, Physiologic; Piperazines; Vestibule, Labyrinth | 1989 |
Differences in results from in vivo and in vitro studies on the use-dependency of N-methylaspartate antagonism by MK-801 and other phencyclidine receptor ligands.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Ketamine; N-Methylaspartate; Phencyclidine; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine; Spinal Cord; Substance-Related Disorders | 1988 |
N-methyl-D-aspartate (NMDA) receptors control respiratory off-switch in cat.
Topics: Action Potentials; Animals; Aspartic Acid; Cats; Dibenzocycloheptenes; Dizocilpine Maleate; Iontophoresis; Ketamine; N-Methylaspartate; Oxadiazoles; Phencyclidine; Phrenic Nerve; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Respiration; Respiratory Center | 1988 |
Phencyclidine receptor ligands attenuate cortical neuronal injury after N-methyl-D-aspartate exposure or hypoxia.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; L-Lactate Dehydrogenase; Ligands; Mice; N-Methylaspartate; Neurons; Oxygen; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1988 |
MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.
Topics: Anesthesia; Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Catalepsy; Columbidae; Dibenzocycloheptenes; Discrimination Learning; Dizocilpine Maleate; Ketamine; Macaca mulatta; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Self Administration; Synaptic Transmission | 1988 |
A potential role for excitotoxins in the pathophysiology of spinal cord injury.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord Injuries; Stereoisomerism; Toxins, Biological | 1988 |
The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro.
Topics: Animals; Aspartic Acid; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Interactions; Electrophysiology; Kainic Acid; N-Methylaspartate; Osmolar Concentration; Phencyclidine; Receptors, Amino Acid; Receptors, Cell Surface | 1988 |
Stereoselective antagonism of NMDA-stimulated noradrenaline release from rat hippocampal slices by MK-801.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; Isomerism; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Release of [3H]norepinephrine from rat hippocampal slices by N-methyl-D-aspartate: comparison of the inhibitory effects of Mg2+ and MK-801.
Topics: Amino Acids; Animals; Aspartic Acid; Convulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1988 |
NMDA receptor channels: labeling of MK-801 with iodine-125 and fluorine-18.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Chemical Phenomena; Chemistry; Dibenzocycloheptenes; Dizocilpine Maleate; Fluorine Radioisotopes; Iodine Radioisotopes; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cortical Spreading Depression; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Ketamine; Male; N-Methylaspartate; Phencyclidine; Phenytoin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes; Valine | 1987 |
The pharmacological selectivity of three NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hexamethonium Compounds; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Norepinephrine; Piperazines; Rats; Serotonin; Synaptic Transmission; Valine | 1988 |
Excitatory amino acid antagonists and endogenous aspartate and glutamate release from rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Tetrodotoxin; Valine | 1988 |
Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801.
Topics: Animals; Anticonvulsants; Aspartic Acid; Calcium; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; N-Methylaspartate; Rats; Retina; Retinal Ganglion Cells | 1988 |
Focal cerebral ischaemia in the cat: treatment with the glutamate antagonist MK-801 after induction of ischaemia.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain Ischemia; Cats; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate | 1988 |
Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Ibotenic Acid; Isoflurane; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Piperazines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Time Factors | 1988 |
Both competitive and non-competitive antagonists of N-methyl-D-aspartic acid disrupt brightness discrimination in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Light; Male; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred F344 | 1988 |
Dextromethorphan inhibits NMDA-induced convulsions.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dextromethorphan; Dibenzocycloheptenes; Dizocilpine Maleate; Levorphanol; Male; Mice; N-Methylaspartate; Psychomotor Performance; Seizures | 1988 |
N-methyl-D-aspartate antagonist MK801 improves outcome following traumatic spinal cord injury in rats: behavioral, anatomic, and neurochemical studies.
Topics: Animals; Aspartic Acid; Blood Pressure; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Intravenous; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord Injuries; Time Factors | 1988 |
The NMDA antagonists MK801 and CPP disrupt compensation for unilateral labyrinthectomy in the guinea pig.
Topics: Adaptation, Physiological; Afferent Pathways; Animals; Aspartic Acid; Denervation; Dibenzocycloheptenes; Dizocilpine Maleate; Ear, Inner; Guinea Pigs; N-Methylaspartate; Neuronal Plasticity; Nystagmus, Pathologic; Piperazines; Vestibule, Labyrinth | 1988 |
Respiratory effects of the N-methyl-D-aspartate (NMDA) antagonist, MK-801, in intact and vagotomized chronic cats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Behavior, Animal; Cats; Dibenzocycloheptenes; Dizocilpine Maleate; Electroencephalography; N-Methylaspartate; Pentobarbital; Plethysmography; Respiration; Vagotomy | 1988 |
Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release.
Topics: Animals; Aspartic Acid; Catecholamines; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats | 1988 |
Inhibition of N-methyl-D-aspartate evoked sodium flux by MK-801.
Topics: Animals; Anticonvulsants; Aspartic Acid; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; Kinetics; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Sodium | 1988 |
Quantitative autoradiography of [3H]-MK-801 binding sites in mammalian brain.
Topics: Animals; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Ischemia; Densitometry; Dibenzocycloheptenes; Dizocilpine Maleate; Gerbillinae; Glutamates; In Vitro Techniques; Muscle, Smooth, Vascular; N-Methylaspartate; Rats; Rats, Inbred Strains; Synaptic Membranes | 1988 |
Antagonism of N-methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK-801.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Female; Ketamine; Male; N-Methylaspartate; Rats; Synapses; Thalamus | 1988 |
Systemic administration of MK-801 prevents N-methyl-D-aspartate-induced neuronal degeneration in rat brain.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Rats; Rats, Inbred Strains | 1987 |
MK-801 powerfully protects against N-methyl aspartate neurotoxicity.
Topics: Animals; Anticonvulsants; Aspartic Acid; Autoradiography; Binding, Competitive; Chick Embryo; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Kainic Acid; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains | 1987 |
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
Topics: Animals; Anticonvulsants; Aspartic Acid; Binding Sites; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Ketamine; Male; N-Methylaspartate; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains | 1986 |
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine Maleate; Glioma; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Ion Channels; Kainic Acid; Kinetics; Magnesium Chloride; N-Methylaspartate; Neurotoxins; Pyrrolidinones; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Signal Transduction; Tumor Cells, Cultured | 1994 |
Blockers of NMDA-operated channels decrease glutamate and aspartate extracellular accumulation in striatum during forebrain ischaemia in rats.
Topics: Animals; Aspartic Acid; Brain Ischemia; Calcium; Corpus Striatum; Dizocilpine Maleate; Glutamic Acid; Magnesium; Male; Microdialysis; Prosencephalon; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1995 |
Effect of oxidative stress on the release of [3H]GABA in cultured chick retina cells.
Topics: Animals; Ascorbic Acid; Aspartic Acid; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Iron; Lipid Peroxidation; Nicotinic Acids; Nipecotic Acids; Oxidative Stress; Oximes; Potassium; Receptors, Glutamate; Retina | 1994 |
Aminooxyacetic acid striatal lesions attenuated by 1,3-butanediol and coenzyme Q10.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Butylene Glycols; Coenzymes; Corpus Striatum; Dizocilpine Maleate; Ketone Bodies; Malates; Male; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Neurotransmitter Agents; Oxidative Phosphorylation; Rats; Rats, Sprague-Dawley; Rotenone; Ubiquinone | 1994 |
Excitatory amino acid-induced phosphoinositide hydrolysis in Müller glia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Chickens; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; Kainic Acid; N-Methylaspartate; Neuroglia; Quinoxalines; Quisqualic Acid; Receptors, Amino Acid; Retina; Tritium | 1993 |
Long-lasting effects of chronic neonatal blockade of N-methyl-D-aspartate receptor through the competitive antagonist CGP 39551 in rats.
Topics: 2-Amino-5-phosphonovalerate; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Aging; Animals; Animals, Newborn; Aspartic Acid; Benzamides; Benzazepines; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Glutamate Decarboxylase; Glutamate-Ammonia Ligase; Motor Activity; Nutrition Disorders; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate | 1994 |
Cerebral metabolic changes induced by MK-801: a 1D (phosphorus and proton) and 2D (proton) in vivo NMR spectroscopy study.
Topics: Animals; Aspartic Acid; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroencephalography; Energy Metabolism; Glucose; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Male; Phosphates; Phosphocreatine; Phosphorus; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 1994 |
An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Male; Microinjections; Nerve Degeneration; Niacin; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Serine; Threonine | 1993 |
The effect of N-acetylaspartate on the intracellular free calcium concentration in NTera2-neurons.
Topics: Analysis of Variance; Animals; Aspartic Acid; Calcium; Dizocilpine Maleate; Dose-Response Relationship, Drug; Neurons; Receptors, N-Methyl-D-Aspartate; Time Factors | 1995 |
L-2-chloropropionic acid-induced neurotoxicity is prevented by MK-801: possible role of NMDA receptors in the neuropathology.
Topics: Administration, Oral; Animals; Aspartic Acid; Autoradiography; Brain Edema; Cerebellum; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamic Acid; Golgi Apparatus; Hydrocarbons, Chlorinated; Injections, Intraperitoneal; Male; Motor Activity; Neuroprotective Agents; Neurotoxins; Propionates; Purkinje Fibers; Rats; Receptors, N-Methyl-D-Aspartate; Sodium; Stereoisomerism; Synaptic Transmission; Taurine | 1996 |
The effect of the desglycinyl metabolite of remacemide hydrochloride (FPL 12495AA) and dizocilpine (MK-801) on endogenous amino acid release from mouse cortex.
Topics: Acetamides; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Phenethylamines; Potassium; Veratridine | 1995 |
Pharmacology of N-methyl-D-aspartate-evoked [3H]noradrenaline release in adult rat spinal cord.
Topics: Animals; Aspartic Acid; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tritium | 1996 |
Contributing mechanisms for cysteine excitotoxicity in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Bicarbonates; Biological Transport; Cell Death; Cells, Cultured; Cerebellum; Culture Media; Cysteine; Dithiothreitol; Dizocilpine Maleate; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Neurons; Neurotoxins; Rats; Rats, Wistar | 1996 |
Effects of vinconate on age-related alterations in [3H]MK-801, [3H]glycine, sodium-dependent D-[3H]aspartate, [3H]FK-506 and [3H]PN200-110 binding in rats.
Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Calcium Channels; Carrier Proteins; Dizocilpine Maleate; DNA-Binding Proteins; Excitatory Amino Acid Antagonists; Glycine; Heat-Shock Proteins; Isradipine; Male; Rats; Rats, Inbred F344; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Sodium; Tacrolimus; Tacrolimus Binding Proteins; Tissue Distribution; Vinca Alkaloids | 1997 |
Effects of chronic treatment with a cyclic AMP-selective phosphodiesterase inhibitor, rolipram, on excitatory amino acid neurotransmission systems in young and aged rat brains.
Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Brain Chemistry; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; GABA Agonists; Glycine; Male; Muscimol; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Synaptic Transmission | 1997 |
Effects of excitatory amino acid antagonists on dendrotoxin-induced increases in neurotransmitter release and epileptiform bursting in rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; Animals; Aspartic Acid; Dizocilpine Maleate; Elapid Venoms; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Neurotoxins; Neurotransmitter Agents; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1997 |
Glutamate receptors in the postmortem striatum of schizophrenic, suicide, and control brains.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Antipsychotic Agents; Aspartic Acid; Autoradiography; Basal Ganglia; Brain Chemistry; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Humans; Kainic Acid; Male; Middle Aged; Neostriatum; Receptors, AMPA; Receptors, Glutamate; Schizophrenia; Suicide | 1997 |
Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Aspartic Acid; Butylated Hydroxytoluene; Cells, Cultured; Cerebellar Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Free Radical Scavengers; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Piperidines; Putrescine; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Vitamin E | 1997 |
Exocytotic and nonexocytotic modes of glutamate release from cultured cerebellar granule cells during chemical ischaemia.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Aspartic Acid; Brain Ischemia; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Cytoplasm; Deoxyglucose; Dizocilpine Maleate; Exocytosis; Fluorescent Dyes; Glutamic Acid; Macrolides; Neurons; omega-Conotoxins; Peptides; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Cyanide; Tetanus Toxin; Time Factors | 1998 |
Aspartate as a selective NMDA receptor agonist in cultured cells from the avian retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Retina | 1998 |
A presynaptic N-methyl-D-aspartate autoreceptor in rat hippocampus modulating amino acid release from a cytoplasmic pool.
Topics: Animals; Aspartic Acid; Autoreceptors; Calcium; Cytoplasm; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Ion Channel Gating; Magnesium; Male; Microscopy, Electron; Neurotransmitter Agents; Potassium Chloride; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1998 |
Effect of CGP 36742 on the extracellular level of neurotransmitter amino acids in the thalamus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extracellular Space; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kinetics; Male; Microdialysis; Neurotransmitter Agents; Organophosphorus Compounds; Rats; Rats, Wistar; Receptors, GABA-B; tau Proteins; Thalamus | 1999 |
Differential regulation of glutamate, aspartate and gamma-amino-butyrate release by N-methyl-D-aspartate receptors in rat striatum after partial and extensive lesions to the nigro-striatal dopamine pathway.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Homeostasis; Kinetics; Male; Microdialysis; Oxidopamine; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substantia Nigra | 1999 |
Differential effects of haloperidol and clozapine on ionotropic glutamate receptors in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Aspartic Acid; Binding Sites; Brain; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1999 |
Neuroprotective effect of lamotrigine and MK-801 on rat brain lesions induced by 3-nitropropionic acid: evaluation by magnetic resonance imaging and in vivo proton magnetic resonance spectroscopy.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Choline; Corpus Striatum; Creatine; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; Lamotrigine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neuroprotective Agents; Nitro Compounds; Propionates; Rats; Rats, Sprague-Dawley; Triazines | 2000 |
Deramciclane inhibits N-methyl-D-aspartate receptor function.
Topics: 4-Aminopyridine; Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Calcium; Camphanes; Cerebral Cortex; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Magnesium; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2000 |
Spinal cord protection: effect of N-methyl-D-aspartate receptor antagonist MK-801 for spinal cord ischemia in a rabbit model.
Topics: Animals; Aspartic Acid; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Ischemia; Rabbits; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2000 |
Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats.
Topics: Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Picrotoxin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures | 2000 |
Neurochemical changes after morphine, dizocilpine or riluzole in the ventral posterolateral thalamic nuclei of rats with hyperalgesia.
Topics: Analysis of Variance; Animals; Arginine; Aspartic Acid; Carrageenan; Citrulline; Dialysis Solutions; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamic Acid; Hindlimb; Hyperalgesia; Male; Microdialysis; Morphine; Neuroprotective Agents; Rats; Rats, Wistar; Riluzole; Thalamic Nuclei | 2000 |
beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Astrocytes; Basal Nucleus of Meynert; Calcium; Calcium Radioisotopes; Cells, Cultured; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Microdialysis; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate; Taurine | 2000 |
Exogenous aspartate neurotoxicity in the spinal cord under metabolic stress in vivo.
Topics: Animals; Aspartic Acid; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Models, Animal; Neurons; Paraplegia; Rabbits; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stress, Physiological | 2000 |
Neuroprotective effects of MK-801 on L-2-chloropropionic acid-induced neurotoxicity.
Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; Body Weight; Carbon Isotopes; Cerebellum; Creatine; Dizocilpine Maleate; Drug Administration Schedule; Energy Metabolism; Gas Chromatography-Mass Spectrometry; Glucose; Hand Strength; Hydrocarbons, Chlorinated; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Neuroprotective Agents; Propionates; Prosencephalon; Rats | 2001 |
Significance of glutamate and dopamine neurons in the ventral pallidum in the expression of behavioral sensitization to amphetamine.
Topics: Amphetamine; Animals; Aspartic Acid; Behavior, Animal; Central Nervous System Stimulants; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Globus Pallidus; Glutamic Acid; Male; Motor Activity; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2001 |
MK801 decreases glutamate release and oxidative metabolism during hypoglycemic coma in piglets.
Topics: Animals; Aspartic Acid; Brain Chemistry; Cerebrovascular Circulation; Coma; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hypoglycemia; Microdialysis; Neurotoxins; Oxygen; Oxygen Consumption; Receptors, N-Methyl-D-Aspartate; Swine | 2001 |
Comparison between hypothermia and glutamate antagonism treatments on the immediate outcome of perinatal asphyxia.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Aspartic Acid; Asphyxia Neonatorum; Behavior, Animal; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Kidney; Lactic Acid; Maternal Behavior; Microdialysis; Pyruvic Acid; Quinoxalines; Rats; Receptors, Glutamate; Survival Rate; Treatment Outcome | 2001 |
Effects of metabotropic glutamate receptor agonists and antagonists on D-aspartate release from mouse cerebral cortical and striatal slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; N-Methylaspartate; Receptors, Metabotropic Glutamate; Tritium | 2001 |
Cooperation between independent hippocampal synapses is controlled by glutamate uptake.
Topics: Animals; Aspartic Acid; Biological Transport; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Patch-Clamp Techniques; Piperazines; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses | 2002 |
A comparison of some metabolic effects of N-methylaspartate stereoisomers, glutamate and depolarization: a multinuclear MRS study.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Dizocilpine Maleate; Electrophysiology; Energy Metabolism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Lactic Acid; Magnetic Resonance Spectroscopy; N-Methylaspartate; Osmolar Concentration; Phosphocreatine; Stereoisomerism | 2002 |
Dizocilpine inhibits amphetamine-induced formation of nitric oxide and amphetamine-induced release of amino acids and acetylcholine in the rat brain.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Brain; Cerebral Cortex; Corpus Striatum; Dextroamphetamine; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamic Acid; Lipid Peroxidation; Male; Neuroprotective Agents; Nitric Oxide; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 2002 |
Oxidative neuronal death caused by glutamate uptake inhibition in cultured hippocampal neurons.
Topics: Acetylcysteine; Amino Acid Transport System X-AG; Animals; Antioxidants; Aspartic Acid; Cell Death; Cells, Cultured; Dicarboxylic Acids; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glutamic Acid; Glutathione; Hippocampus; Neurons; Neurotransmitter Uptake Inhibitors; Oxidative Stress; Pyrrolidines; Rats; Rats, Wistar; Reactive Oxygen Species | 2003 |
Activity-dependent remodeling of presynaptic inputs by postsynaptic expression of activated CaMKII.
Topics: Alanine; Anesthetics, Local; Animals; Animals, Newborn; Aspartic Acid; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Count; Cell Surface Extensions; Cerebral Cortex; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorescent Dyes; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Immunohistochemistry; Luminescent Proteins; Lysine; Mutation; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Organ Culture Techniques; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Rats, Long-Evans; Synapses; Synapsins; Synaptic Transmission; Tetrodotoxin; Threonine; Transfection; Valine | 2003 |
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis.
Topics: Animals; Aspartic Acid; Axons; Benzoxazines; Cannabinoids; Cyclohexanols; Dizocilpine Maleate; Encephalomyelitis, Autoimmune, Experimental; Excitatory Amino Acid Agonists; Gene Deletion; Humans; Mice; Mice, Transgenic; Monomeric GTP-Binding Proteins; Morpholines; Multiple Sclerosis; N-Methylaspartate; Naphthalenes; Nerve Degeneration; Nuclear Proteins; Receptors, Cannabinoid; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Retina; Saccharomyces cerevisiae Proteins; Spinal Cord; Uveitis | 2003 |
Neuroprotective effects of N-methyl-D-aspartate receptor antagonist on aspartate induced neurotoxicity in the spinal cord in vivo.
Topics: Animals; Aspartic Acid; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Neurons; Neuroprotective Agents; Paraplegia; Pipecolic Acids; Rabbits; Spinal Cord | 2003 |
Increasing of intrathecal CSF excitatory amino acids concentration following morphine challenge in morphine-tolerant rats.
Topics: Analgesics, Opioid; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Injections, Spinal; Male; Microdialysis; Morphine; Pain; Pain Measurement; Rats; Rats, Wistar; Time Factors | 2004 |
Extracellular excitatory amino acids increase in the paraventricular nucleus of male rats during sexual activity: main role of N-methyl-d-aspartic acid receptors in erectile function.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Analysis of Variance; Animals; Aspartic Acid; Behavior, Animal; Copulation; Dialysis; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Penile Erection; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Sexual Behavior, Animal | 2004 |
Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density.
Topics: 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Dizocilpine Maleate; Drug Interactions; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Models, Neurological; N-Methylaspartate; Neural Inhibition; Neurons; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Synapses | 2004 |
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
Excitotoxic death induced by released glutamate in depolarized primary cultures of mouse cerebellar granule cells is dependent on GABAA receptors and niflumic acid-sensitive chloride channels.
Topics: Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Chloride Channels; Chlorides; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Immunohistochemistry; Mice; Naphthalenes; Neurons; Neurotoxins; Niflumic Acid; Oxepins; Potassium Chloride; Propidium; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Riluzole; Tritium | 2005 |
Effects of glutamate transporter and receptor ligands on neuronal glutamate uptake.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ligands; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Oxepins; Rats; Rats, Wistar; Receptors, Glutamate; Tritium; Valine | 2005 |
Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Blotting, Western; Cell Death; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Gene Expression Regulation, Developmental; Glutamic Acid; Heptanes; Heterocyclic Compounds, 3-Ring; Hippocampus; Homeostasis; Humans; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Time Factors; Tritium | 2005 |
Impaired glutamine metabolism in NMDA receptor hypofunction induced by MK801.
Topics: Animals; Aspartic Acid; Brain; Cell Communication; Dizocilpine Maleate; Down-Regulation; Energy Metabolism; Excitatory Amino Acid Antagonists; Frontal Lobe; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Glutathione; Inositol; Male; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Succinic Acid; Temporal Lobe; Up-Regulation | 2005 |
Modulation of aspartate release by ascorbic acid and endobain E, an endogenous Na+, K+ -ATPase inhibitor.
Topics: Animals; Ascorbic Acid; Aspartic Acid; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Nerve Tissue Proteins; Neurotransmitter Agents; Ouabain; Pyridines; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Spectrophotometry, Ultraviolet; Synaptosomes | 2005 |
Ionotropic glutamate receptors and glutamate transporters are involved in necrotic neuronal cell death induced by oxygen-glucose deprivation of hippocampal slice cultures.
Topics: Amino Acid Transport System X-AG; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Cell Death; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glial Fibrillary Acidic Protein; Glucose; Hippocampus; Histocytochemistry; Hypoxia; Immunohistochemistry; In Vitro Techniques; Microtubule-Associated Proteins; Necrosis; Neurofilament Proteins; Neurons; Neuroprotective Agents; Propidium; Quinoxalines; Rats; Receptors, Glutamate; Time Factors | 2005 |
In vitro toxicity of tetrabromobisphenol-A on cerebellar granule cells: cell death, free radical formation, calcium influx and extracellular glutamate.
Topics: Animals; Aspartic Acid; Calcium; Caspase Inhibitors; Caspases; Cell Death; Cell Nucleus; Cell Survival; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Dizocilpine Maleate; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Space; Glutamates; Hazardous Substances; Intracellular Fluid; Mitogen-Activated Protein Kinase 3; Nucleosomes; Okadaic Acid; Polybrominated Biphenyls; Protein-Tyrosine Kinases; Rats; Reactive Oxygen Species; Vitamin E | 2007 |
Membrane currents and cytoplasmic sodium transients generated by glutamate transport in Bergmann glial cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Calcium; Cerebellum; Cytoplasm; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagonists; Glucosamine; Glutamic Acid; Kainic Acid; Lithium; Membrane Potentials; Mice; Mice, Inbred Strains; Models, Biological; Nerve Fibers; Neuroglia; Sodium; Sodium-Calcium Exchanger | 2007 |
Mechanisms of sodium azide-induced changes in intracellular calcium concentration in rat primary cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Algorithms; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Cerebral Cortex; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Extracellular Space; Neurons; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Azide | 2007 |
Neuroprotective potential of ceftriaxone in in vitro models of stroke.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anti-Bacterial Agents; Aspartic Acid; Ceftriaxone; Cell Death; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Hippocampus; Hypoxia; Membrane Potentials; Neurons; Neuroprotective Agents; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Stroke; Time Factors | 2007 |
Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs.
Topics: Animals; Aspartic Acid; Diazonium Compounds; Dizocilpine Maleate; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Patch-Clamp Techniques; Pyridines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 2008 |
NMDA receptors mediate an early up-regulation of brain-derived neurotrophic factor expression in substantia nigra in a rat model of presymptomatic Parkinson's disease.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain-Derived Neurotrophic Factor; Cell Count; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Functional Laterality; Glutamic Acid; Male; Microdialysis; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase; Up-Regulation | 2009 |
Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuregulin-1; Phencyclidine; Phenotype; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Sex Factors; Social Behavior | 2010 |
Homeostatic regulation of glutamate neurotransmission in primary neuronal cultures.
Topics: Amino Acid Transport System X-AG; Aniline Compounds; Animals; Aspartic Acid; Biological Transport, Active; Brain; Calcium Signaling; Dizocilpine Maleate; Embryo, Mammalian; Female; Fluorescent Dyes; Glutamic Acid; Homeostasis; Mice; Neurons; Neurotransmitter Agents; Pregnancy; Primary Cell Culture; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Xanthenes | 2011 |
Central injection of L- and D-aspartate attenuates isolation-induced stress behavior in chicks possibly through different mechanisms.
Topics: Animals; Animals, Newborn; Aspartic Acid; Behavior, Animal; Chickens; Dizocilpine Maleate; Hypnotics and Sedatives; Injections, Intraventricular; Receptors, N-Methyl-D-Aspartate; Social Isolation; Stress, Psychological | 2014 |
Mechanisms regulating spill-over of synaptic glutamate to extrasynaptic NMDA receptors in mouse substantia nigra dopaminergic neurons.
Topics: Amino Acids; Animals; Aspartic Acid; Dizocilpine Maleate; Dopaminergic Neurons; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Synapses; Xanthenes | 2015 |
Failure and rescue of preconditioning-induced neuroprotection in severe stroke-like insults.
Topics: 4-Aminopyridine; Animals; Aspartic Acid; Bicuculline; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Dizocilpine Maleate; Glucose; Glutamic Acid; Ischemic Preconditioning; Neurons; Neuroprotective Agents; Ouabain; Rats; Stroke; Time Factors | 2016 |