aspartic acid has been researched along with deuterium in 86 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (43.02) | 18.7374 |
| 1990's | 19 (22.09) | 18.2507 |
| 2000's | 22 (25.58) | 29.6817 |
| 2010's | 8 (9.30) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cronholm, T | 1 |
| Beguin, CG; Chesne, S; Gout, E; Pelmont, J | 1 |
| Chang, M; Lanyi, JK; Maeda, A; Needleman, R; Ni, B; Sasaki, J; Shichida, Y; Yoshizawa, T | 1 |
| Rupitz, K; Trimbur, D; Warren, RA; Withers, SG | 1 |
| Kagamiyama, H; Kuramitsu, S; Morino, Y; Tanase, S; Yano, T | 1 |
| Cleland, WW; Lee, S; O'Leary, MH; Parmentier, LE; Schachman, HK; Turnbull, JL; Waldrop, GL | 1 |
| Arakawa, T; Prestrelski, SJ | 1 |
| Cuénod, M; Perschak, H | 1 |
| Northrop, DB; Rebholz, KL | 1 |
| Chang, LH; Cohen, Y; James, TL; Litt, L; Nishimura, MC; Pitts, LH; Sanada, T; Weinstein, PR | 1 |
| Julin, DA; Kirsch, JF | 1 |
| Morrison, JF; Stone, SR | 1 |
| Akhtar, M; Botting, NP; Cohen, MA; Gani, D | 1 |
| Howell, EE; Kraut, J; Oatley, SJ; Villafranca, JE; Warren, MS | 1 |
| Blattmann, P; Rétey, J | 1 |
| Castillo, CL; Mayer, A; Ogawa, S; Shulman, RG | 1 |
| Evans, DR; McMurray, CH; Sykes, BD | 1 |
| Mackall, JC; Neet, KE | 1 |
| Dunstan, D; Hough, L | 1 |
| Keys, WE; Legg, JI | 1 |
| Kirby, GW; Michael, J | 1 |
| Bystrov, VF; Chervin, II; Dudkin, SM; Karpeisky, MY; Sacharovsky, VG; Shliapnikov, SV; Yakovlev, GI | 1 |
| Robillard, G; Shulman, RG | 1 |
| Chroboczek Kelker, H | 1 |
| Stark, GR | 1 |
| Barker, HA; Eagar, RG; Herbst, MM; Richards, JH | 1 |
| Dougherty, TB; Williams, VR; Younathan, ES | 1 |
| Dubin, P; Karasz, FE | 1 |
| Scheraga, HA; Silverman, DN; Taylor, GT | 1 |
| Blomquist, AT; Cedergren, RJ; Harpp, DN; Hiscock, BF; Tripp, SL | 1 |
| Kobayashi, Y; Makino, K | 1 |
| Cohen, JS; Putter, I | 1 |
| Rose, PI | 1 |
| Kirschner, MW; Schachman, HK | 1 |
| Scheraga, HA; Silverman, DN | 1 |
| Jardetzky, O; Markley, JL; Putter, I | 1 |
| Bradbury, EM; Carpenter, BG; Crane-Robinson, C; Rattle, HW | 1 |
| Rüterjans, H; Witzel, H | 1 |
| Blake, MI; Fang, SM; Rhodes, HJ | 1 |
| Sprecher, M; Sprinson, DB; Switzer, RL | 1 |
| Blomquist, AT; Harpp, DN; Hiscock, BF | 1 |
| Cerdán, S; Erhard, P; Moldes, M; Seelig, J | 1 |
| Deutsch, JC; Hassell, KL; Kolhouse, JC; Kolhouse, JF; Santhosh-Kumar, CR | 1 |
| Bommer, JC; Spikes, JD | 1 |
| Ostanin, K; Van Etten, RL | 1 |
| Goldberg, JM; Kirsch, JF | 1 |
| Daikhin, Y; Miller, SL; Yudkoff, M | 1 |
| Ferreira, GC; Gong, J; Hunter, GA | 1 |
| Overman, SA; Thomas, GJ | 1 |
| Green, EL; Klinman, JP; Plastino, J; Sanders-Loehr, J | 1 |
| Arata, Y; Ito, S; Kawaminami, S; Shimada, I; Takahashi, H | 1 |
| Christen, P; Graber, R; Mahon, MM; Malthouse, JP | 1 |
| Lee, JP; Zhang, S | 1 |
| Ferry, JG; Tripp, BC | 1 |
| Digits, JA; Hedstrom, L; Kerr, KM; Kuperwasser, N | 1 |
| Crowder, MW; Taylor, RA; Yanchak, MP | 1 |
| Daubner, SC; Fitzpatrick, PF; Sobrado, P | 1 |
| Guengerich, FP; Miller, GP; Yun, CH | 1 |
| Bagwell, C; Banik, U; Dunn, MF; Hur, O; Miles, EW; Weber-Ban, E; Yang, LH | 1 |
| Basran, J; Scrutton, NS; Sutcliffe, MJ | 1 |
| Buijs, J; Hagman, C; Håkansson, K; Håkansson, P; Oscarsson, S; Richter, JH | 1 |
| Glavas, S; Tanner, ME | 1 |
| Dunn, MF; Ferrari, D; Miles, EW; Yang, LH | 1 |
| Cook, PF; Hwang, CC; Liu, D | 1 |
| Cook, PF; Daum, S; Tai, CH | 1 |
| OSHIMA, T; TAMIYA, N | 1 |
| SPRECHER, M; SPRINSON, DB | 1 |
| BRIGHT, H | 1 |
| BRIGHT, HJ; INGRAHAM, LL; LUNDIN, RE | 1 |
| Fitzpatrick, PF; Valley, MP | 1 |
| Herrmann, KA; Vorpagel, ER; Wysocki, VH | 1 |
| Oikawa, H; Tokiwano, T; Watanabe, H | 1 |
| Hanson, BL; Langan, P; Liu, X; Viola, RE | 1 |
| Andersson, J; Barth, A; Hauser, K; Karjalainen, EL | 1 |
| Janke, EM; Weisz, K | 1 |
| Cook, PF; Guan, R; Huang, B; Roderick, SL | 1 |
| Gennis, RB; Lugtenburg, J; Maeda, A; Morgan, JE; Vakkasoglu, AS | 1 |
| Hansen, PE; Tomlinson, JH; Ullah, S; Williamson, MP | 1 |
| Chen, C; Corpeleijn, WE; Huang, Y; Riedijk, MA; Schierbeek, H; van Goudoever, JB; Zhou, Y | 1 |
| Håkansson, K; Marsh, EN; Song, H; Yoon, M | 1 |
| Kay, LE; Ruschak, AM; Velyvis, A | 1 |
| Barbie, P; Huo, L; Kazmaier, U; Müller, R | 1 |
| Casseb, RF; Castellano, G; Cendes, F; D'Abreu, A; Lopes-Cendes, I; Ruocco, HH | 1 |
| Chen, G; Das, TK; Fu, Y; Jusuf, S; Krystek, SR; Ludwig, R; Tao, L; Wei, H; Yan, Y; Zeng, M | 1 |
| Danmaliki, GI; Hwang, PM; Liu, PB | 1 |
| Gellman, AJ; Karagoz, B; Reinicker, A | 1 |
86 other study(ies) available for aspartic acid and deuterium
| Article | Year |
|---|---|
Incorporation of the hydrogen atoms of ethanol into amino acids in rat liver in vivo.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Chemical Phenomena; Chemistry; Deuterium; Ethanol; Female; Glutamates; Hydrogen; Liver; NAD; Proline; Rats | 1979 |
Kinetic studies with the use of proton-magnetic-resonance spectroscopy of the specific alpha-deuteration of amino acids by Escherichia coli aspartate aminotransferase.
Topics: Aspartate Aminotransferases; Aspartic Acid; Deuterium; Escherichia coli; Kinetics; Magnetic Resonance Spectroscopy; Phenylalanine | 1978 |
Structures of aspartic acid-96 in the L and N intermediates of bacteriorhodopsin: analysis by Fourier transform infrared spectroscopy.
Topics: Acetates; Acetic Acid; Amino Acid Sequence; Aspartic Acid; Bacteriorhodopsins; Carbon Isotopes; Deuterium; Fourier Analysis; Hydrogen Bonding; Mutation; Protons; Schiff Bases; Spectrophotometry, Infrared; Structure-Activity Relationship | 1992 |
Mechanistic consequences of mutation of the active site nucleophile Glu 358 in Agrobacterium beta-glucosidase.
Topics: Asparagine; Aspartic Acid; beta-Glucosidase; Binding Sites; Deuterium; Drug Stability; Glucosides; Glutamates; Glutamic Acid; Glutamine; Glycosylation; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Protein Conformation; Rhizobium; Structure-Activity Relationship | 1992 |
Role of Asp222 in the catalytic mechanism of Escherichia coli aspartate aminotransferase: the amino acid residue which enhances the function of the enzyme-bound coenzyme pyridoxal 5'-phosphate.
Topics: Aspartate Aminotransferases; Aspartic Acid; Base Sequence; Catalysis; Circular Dichroism; Deuterium; Escherichia coli; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyridoxal Phosphate; Spectrophotometry; Structure-Activity Relationship | 1992 |
The contribution of threonine 55 to catalysis in aspartate transcarbamoylase.
Topics: Aspartate Carbamoyltransferase; Aspartic Acid; Base Sequence; Carbamyl Phosphate; Carbon Isotopes; Catalysis; Deuterium; Hydrogen-Ion Concentration; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitrogen Isotopes; Oligonucleotides; Phosphonoacetic Acid; Structure-Activity Relationship; Succinates; Threonine | 1992 |
The solution structure and conformational dynamics of tumor necrosis factor-alpha and a (Cys69----Asp; Cys101----Arg) analog as examined by IR spectroscopy and hydrogen exchange.
Topics: Animals; Arginine; Aspartic Acid; Cysteine; Deuterium; Hydrogen; Mutagenesis, Site-Directed; Protein Conformation; Spectrophotometry, Infrared; Tumor Necrosis Factor-alpha | 1991 |
In vivo release of endogenous glutamate and aspartate in the rat striatum during stimulation of the cortex.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Deuterium; Electric Stimulation; Glutamates; Glutamic Acid; Kinetics; Leucine; Male; Rats; Rats, Inbred Strains | 1990 |
Slow step after bond-breaking by porcine pepsin identified using solvent deuterium isotope effects.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Deuterium; Kinetics; Molecular Sequence Data; Oligopeptides; Pepsin A; Solvents; Swine | 1991 |
Surface coil spectroscopic imaging: time and spatial evolution of lactate production following fluid percussion brain injury.
Topics: Animals; Aspartic Acid; Brain Concussion; Brain Edema; Brain Injuries; Deuterium; Fourier Analysis; Lactates; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Kinetic isotope effect studies on aspartate aminotransferase: evidence for a concerted 1,3 prototropic shift mechanism for the cytoplasmic isozyme and L-aspartate and dichotomy in mechanism.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Cytosol; Deuterium; Deuterium Oxide; Isoenzymes; Kinetics; Mathematics; Models, Theoretical; Myocardium; Solvents; Swine; Water | 1989 |
Mechanism of the reaction catalyzed by dihydrofolate reductase from Escherichia coli: pH and deuterium isotope effects with NADPH as the variable substrate.
Topics: Aspartic Acid; Deuterium; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Kinetics; NADP; Solvents; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1988 |
Primary deuterium isotope effects for the 3-methylaspartase-catalyzed deamination of (2S)-aspartic acid, (2S,3S)-3-methylaspartic acid, and (2S,3S)-3-ethylaspartic acid.
Topics: Ammonia-Lyases; Aspartic Acid; Binding Sites; Clostridium; Deuterium; Isotope Labeling; Kinetics; Substrate Specificity | 1988 |
Functional role of aspartic acid-27 in dihydrofolate reductase revealed by mutagenesis.
Topics: Aspartic Acid; Crystallography; Deuterium; Escherichia coli; Kinetics; Methotrexate; Mutation; Protein Binding; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1986 |
Stereospecificity of the dihydroorotate-dehydrogenase reaction.
Topics: Asparagine; Aspartic Acid; Bacteria; Benzyl Compounds; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Thin Layer; Deuterium; Esters; Ethanol; Hydrogen; Kinetics; Magnetic Resonance Spectroscopy; NAD; Orotic Acid; Oxidation-Reduction; Oxidoreductases; Structure-Activity Relationship | 1972 |
High-resolution proton NMR studies of low affinity hemoglobins.
Topics: Asparagine; Aspartic Acid; Binding Sites; Carbon Isotopes; Deuterium; Hemoglobins, Abnormal; Histidine; Humans; Hydrogen-Ion Concentration; Iron; Japan; Kansas; Magnetic Resonance Spectroscopy; Methylation; Mutation; Oxyhemoglobins; Protein Binding; Protein Conformation; Threonine; Tyrosine | 1973 |
A nuclear magnetic resonance study of the binding of substrate analogues to a modified aspartate transcarbamylase.
Topics: Acetates; Aspartic Acid; Binding Sites; Carbamates; Deuterium; Escherichia coli; Magnetic Resonance Spectroscopy; Mathematics; Mercury; Nitrophenols; Organometallic Compounds; Phosphoric Acids; Protein Binding; Succinates; Sulfhydryl Reagents; Transferases | 1972 |
Variation of the size of the reacting form of Escherichia coli K12 threonine-sensitive aspartokinase--homoserine dehydrogenase with pH and effectors.
Topics: Alcohol Oxidoreductases; Allosteric Regulation; Aspartic Acid; Deuterium; Drug Stability; Escherichia coli; Homoserine; Hydrogen-Ion Concentration; Macromolecular Substances; Phosphotransferases; Potassium; Protein Conformation; Structure-Activity Relationship; Threonine; Ultracentrifugation; Viscosity | 1973 |
The synthesis of 2-acetamido-1-N-(4-L-aspartyl)-2-deoxy-beta-D-galactopyranosylamine.
Topics: Amidohydrolases; Aspartic Acid; Azides; Chromatography; Circular Dichroism; Deuterium; Galactosamine; Glucosamine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Optical Rotation; Spectrophotometry, Ultraviolet | 1972 |
Asymmetric deuteration at the carbon of L-aspartic acid via the template action of a dissymmetric cobalt(3) complex.
Topics: Aspartic Acid; Cobalt; Deuterium; Isotope Labeling; Stereoisomerism | 1973 |
Stereoselective -labelling of aromatic amino-acids with deuterium and tritium.
Topics: Amines; Aspartic Acid; Carbon Isotopes; Chemical Phenomena; Chemistry; Cinnamates; Deuterium; Hydroxylation; Isotope Labeling; Methods; Phenylalanine; Tritium; Tyrosine | 1973 |
Proton magnetic resonance studies of des-(121-124)-ribonuclease A.
Topics: Animals; Aspartic Acid; Binding Sites; Carboxypeptidases; Cattle; Cytosine Nucleotides; Deuterium; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Pancreas; Protein Binding; Protein Conformation; Ribonucleases; Spectrophotometry, Ultraviolet | 1973 |
High resolution nuclear magnetic resonance studies of the active site of chymotrypsin. I. The hydrogen bonded protons of the "charge relay" system.
Topics: Aspartic Acid; Binding Sites; Chymotrypsin; Chymotrypsinogen; Deuterium; Histidine; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Serine | 1974 |
Activation of aspartate transcarbamoylase by purine nucleotides.
Topics: Acetates; Adenosine Triphosphate; Amino Acids; Aspartic Acid; Centrifugation, Density Gradient; Crystallization; Cytosine Nucleotides; Deuterium; Enzyme Activation; Escherichia coli; Guanine Nucleotides; Kinetics; Magnesium; Pyruvates; Transferases; Tritium | 1970 |
Aspartate transcarbamylase. The use of primary kinetic and solvent deuterium isotope effects to delineate some aspects of the mechanism.
Topics: Anhydrides; Aspartic Acid; Carbamates; Carbon Isotopes; Chemical Phenomena; Chemistry; Deuterium; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Mathematics; Oxygen Isotopes; Transferases | 1971 |
Mechanism of action of coenzyme B 12 . Hydrogen transfer in the isomerization of -methylaspartate to glutamate.
Topics: Aspartic Acid; Chemical Phenomena; Chemistry; Coenzymes; Deuterium; Glutamates; Hydrogen; Isomerases; Kinetics; Mass Spectrometry; Mathematics; Models, Chemical; Vitamin B 12 | 1972 |
Mechanism of action of aspartase. A kinetic study and isotope rate effects with 2 H.
Topics: Ammonium Sulfate; Aspartic Acid; Catalysis; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Deuterium; Enterobacteriaceae; Fumarates; Hydrogen-Ion Concentration; Isotope Labeling; Kinetics; Lyases; Mathematics; Models, Chemical; Quaternary Ammonium Compounds | 1972 |
The absence of an isotope effect on the stability of the poly- -benzyl-L-aspartate -helix in aprotic solvents.
Topics: Aspartic Acid; Benzyl Compounds; Chemical Phenomena; Chemistry; Deuterium; Hot Temperature; Optical Rotatory Dispersion; Peptides; Protein Conformation; Solvents; Thermodynamics | 1972 |
Nuclear magnetic resonance study of the side-chain conformation of -helical poly- -benzyl-L-aspartate.
Topics: Aspartic Acid; Benzyl Compounds; Chloroform; Deuterium; Esters; Magnetic Resonance Spectroscopy; Methylation; Optical Rotatory Dispersion; Peptides; Solutions | 1971 |
Synthesis of highly deuterated amino acids.
Topics: Amino Acids; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Deuterium; Eukaryota; Glutamates; Oxytocin; Phenylalanine; Pigments, Biological; Vasopressins | 1966 |
Nuclear magnetic resonance studies of exchange reaction of alpha-hydrogen of glutamic acid catalyzed by aspartate aminotransferase.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Deuterium; Glutamates; Hydrogen; Magnetic Resonance Spectroscopy; Methods; Myocardium; Oxides; Swine; Ultracentrifugation | 1969 |
The isolation of deuterated amino acids.
Topics: Amino Acids; Aspartic Acid; Autoanalysis; Chromatography, Ion Exchange; Deuterium; Glutamates; Magnetic Resonance Spectroscopy; Methods; Protein Hydrolysates; Tyrosine | 1970 |
Protein-metal ion binding site: determination with proton magnetic resonance spectroscopy.
Topics: Aspartic Acid; Cobalt; Deuterium; Gelatin; Glutamates; Magnetic Resonance Spectroscopy; Protein Binding; Solutions | 1971 |
Conformational changes in proteins as measured by difference sedimentation studies. I. A technique for measuring small changes in sedimentation coefficient.
Topics: Aspartic Acid; Carbamates; Carboxypeptidases; Catalysis; Densitometry; Deuterium; Glyceraldehyde-3-Phosphate Dehydrogenases; Immunoglobulin G; Light; Macromolecular Substances; Mathematics; Methods; Molecular Biology; Molecular Weight; Photography; Plant Viruses; Proteins; Rotation; Spectrum Analysis; Transferases; Ultracentrifugation; Viscosity | 1971 |
Nuclear magnetic resonance studies of side-chain interactions in polyamino acids with aromatic groups. Comparison to conformational energy calculations.
Topics: Amino Acids; Aspartic Acid; Benzyl Compounds; Chemical Phenomena; Chemistry; Deuterium; Fluoroacetates; Glutamates; Magnetic Resonance Spectroscopy; Models, Structural; Phenylalanine; Polymers | 1971 |
High-resolution nuclear magnetic resonance spectra of selectively deuterated staphylococcal nuclease.
Topics: Amino Acids; Asparagine; Aspartic Acid; Calcium; Deoxyribonucleases; Deuterium; Glutamates; Glutamine; Histidine; Magnetic Resonance Spectroscopy; Methionine; Nucleotides; Ribonucleases; Staphylococcus; Tryptophan; Tyrosine | 1968 |
Application of high resolution nuclear magnetic resonance to conformational analyses of polypeptides in solution.
Topics: Aspartic Acid; Chloroform; Deuterium; Fluoroacetates; Glutamates; Magnetic Resonance Spectroscopy; Peptides; Solutions | 1968 |
NMR-studies on the structure of the active site of pancreatic ribonuclease A.
Topics: Amino Acids; Animals; Aspartic Acid; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Deuterium; Histidine; Hydrogen-Ion Concentration; Imidazoles; Magnetic Resonance Spectroscopy; Pancreas; Protein Binding; Protons; Ribonucleases | 1969 |
Synthesis of 2,6-dioxo-3-phthalimidopiperidine-3,4,4,5,5-d, and 2,5-dioxo-3-phthalimidopyrrolidine-3,4,4-d, from L-deuterio-glutamic acid and L-deuterio-aspartic acid.
Topics: Aspartic Acid; Carbon; Chemistry, Pharmaceutical; Deuterium; Eukaryota; Glutamates; Hydrogen; Nitrogen; Piperidines; Thalidomide | 1965 |
Stereochemistry of the glutamate mutase reaction.
Topics: Aspartic Acid; Chemical Phenomena; Chemistry, Physical; Clostridium; Deuterium; Fumarates; Glutamates; In Vitro Techniques; Isomerases; Magnetic Resonance Spectroscopy; Succinates | 1966 |
Deuterated amino acids. 3. Synthesis of DL-Aspartic-2,3,3-d-3 acid, L-glutamic-2,3,3,4,4-d-5 acid, L-asparagine-2,3,3-d-3, and L-Glutamine-2,3,3,4,4-d-5 1,2a.
Topics: Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Chemistry, Organic; Deuterium; Glutamates; Glutamine; Organic Chemistry Phenomena | 1966 |
1H-2H exchange in the perfused rat liver metabolizing [3-13C]alanine and 2H2O as detected by multinuclear NMR spectroscopy.
Topics: Alanine; Animals; Aspartic Acid; Carbon Isotopes; Deuterium; Deuterium Oxide; Glutamic Acid; Hydrogen; Liver; Magnetic Resonance Spectroscopy; Male; Perfusion; Rats; Rats, Sprague-Dawley | 1994 |
Measurement of excitatory sulfur amino acids, cysteine sulfinic acid, cysteic acid, homocysteine sulfinic acid, and homocysteic acid in serum by stable isotope dilution gas chromatography-mass spectrometry and selected ion monitoring.
Topics: Aspartic Acid; Cysteic Acid; Cysteine; Deuterium; Gas Chromatography-Mass Spectrometry; Homocysteine; Humans; Isotope Labeling; Neurotransmitter Agents; Reference Values | 1994 |
Photobleaching of mono-L-aspartyl chlorin e6 (NPe6): a candidate sensitizer for the photodynamic therapy of tumors.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Azides; Deuterium; Humans; Mannitol; Metronidazole; Molecular Structure; Neoplasms; Paraquat; Photochemistry; Photochemotherapy; Photosensitizing Agents; Porphyrins; Solvents | 1993 |
Asp304 of Escherichia coli acid phosphatase is involved in leaving group protonation.
Topics: Acid Phosphatase; Aspartic Acid; Base Sequence; Deuterium; DNA, Single-Stranded; Escherichia coli; Hydrogen-Ion Concentration; Isotopes; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphates; Protons; Substrate Specificity | 1993 |
The reaction catalyzed by Escherichia coli aspartate aminotransferase has multiple partially rate-determining steps, while that catalyzed by the Y225F mutant is dominated by ketimine hydrolysis.
Topics: Aspartate Aminotransferases; Aspartic Acid; Biological Evolution; Catalysis; Computer Simulation; Deuterium; Diffusion; Escherichia coli; Hydrolysis; Imines; Kinetics; Models, Chemical; Mutation; Oxaloacetates; Solvents; Spectrophotometry; Thermodynamics; Transaminases; Viscosity | 1996 |
Metabolism of N-acetyl-L-aspartate in rat brain.
Topics: Animals; Aspartic Acid; Biotransformation; Brain; Deuterium; Female; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Kinetics; Nitrogen Isotopes; Rats; Rats, Inbred F344; Time Factors | 1996 |
Aspartate-279 in aminolevulinate synthase affects enzyme catalysis through enhancing the function of the pyridoxal 5'-phosphate cofactor.
Topics: 5-Aminolevulinate Synthetase; Amino Acid Sequence; Animals; Aspartic Acid; Base Sequence; Binding Sites; Catalysis; Conserved Sequence; Deuterium; DNA Primers; In Vitro Techniques; Kinetics; Mice; Mutagenesis, Site-Directed; Point Mutation; Pyridoxal Phosphate; Recombinant Proteins | 1998 |
Raman markers of nonaromatic side chains in an alpha-helix assembly: Ala, Asp, Glu, Gly, Ile, Leu, Lys, Ser, and Val residues of phage fd subunits.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Deuterium; DNA, Single-Stranded; Glutamic Acid; Glycine; Inovirus; Isoleucine; Lysine; Molecular Sequence Data; Protein Structure, Secondary; Serine; Spectrum Analysis, Raman; Valine; Viral Proteins; Virus Assembly | 1999 |
An unexpected role for the active site base in cofactor orientation and flexibility in the copper amine oxidase from Hansenula polymorpha.
Topics: Amine Oxidase (Copper-Containing); Ammonia; Asparagine; Aspartic Acid; Binding Sites; Carbon; Deuterium; Enzyme Activation; Glutamic Acid; Hydrogen; Methylamines; Mutagenesis, Site-Directed; Oxygen; Pichia; Schiff Bases; Solvents; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Substrate Specificity; Viscosity | 1999 |
A multinuclear NMR study of the active site of an endoglucanase from a strain of Bacillus. Use of Trp residues as structural probes.
Topics: Amino Acid Sequence; Aspartic Acid; Bacillus; Binding Sites; Cellulase; Clostridium; Deuterium; Glutamic Acid; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Sequence Alignment; Tryptophan | 1999 |
The aspartate aminotransferase-catalysed exchange of the alpha-protons of aspartate and glutamate: the effects of the R386A and R292V mutations on this exchange reaction.
Topics: Aspartate Aminotransferases; Aspartic Acid; Deuterium; Glutamic Acid; Glycine Hydroxymethyltransferase; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Mutation; Protons; Stereoisomerism; Tryptophan Synthase | 1999 |
Selectively 2H-labeled Glu/Asp: application to pKa measurements in Abeta amyloid peptides.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Deuterium; Glutamic Acid; Histidine; Isotope Labeling; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptide Fragments; Protein Conformation | 2000 |
A structure-function study of a proton transport pathway in the gamma-class carbonic anhydrase from Methanosarcina thermophila.
Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Biological Transport; Carbonic Anhydrases; Cysteine; Deuterium; Escherichia coli; Genetic Variation; Glutamic Acid; Glutamine; Histidine; Hydrogen-Ion Concentration; Kinetics; Lysine; Methanosarcina; Mutagenesis, Site-Directed; Protons; Serine; Solvents; Structure-Activity Relationship; Threonine; Tryptophan | 2000 |
Asp338 controls hydride transfer in Escherichia coli IMP dehydrogenase.
Topics: Alkylation; Aspartic Acid; Catalysis; Catalytic Domain; Deuterium; Escherichia coli; Hydrogen; IMP Dehydrogenase; Inosine Monophosphate; Kinetics; Models, Chemical; Mutation | 2000 |
Mutational analysis of metallo-beta-lactamase CcrA from Bacteroides fragilis.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Bacterial Proteins; Bacteroides fragilis; beta-Lactamases; Cysteine; Deuterium; DNA Mutational Analysis; DNA, Bacterial; Gene Expression Regulation, Bacterial; Hydrogen-Ion Concentration; Kinetics; Metalloproteins; Mutagenesis, Site-Directed; Protons; Recombinant Proteins; Serine; Solvents; Zinc | 2000 |
Probing the relative timing of hydrogen abstraction steps in the flavocytochrome b2 reaction with primary and solvent deuterium isotope effects and mutant enzymes.
Topics: Asparagine; Aspartic Acid; Binding Sites; Deuterium; Electron Transport; Flavins; Hydrogen Bonding; Kinetics; L-Lactate Dehydrogenase; L-Lactate Dehydrogenase (Cytochrome); Mutagenesis, Site-Directed; Protein Structure, Tertiary; Protons; Saccharomyces cerevisiae; Solvents | 2001 |
Oxidations of p-alkoxyacylanilides catalyzed by human cytochrome P450 1A2: structure-activity relationships and simulation of rate constants of individual steps in catalysis.
Topics: Alanine; Alkylation; Amino Acid Substitution; Aspartic Acid; Catalysis; Cytochrome P-450 CYP1A2; Deuterium; Enzyme Activation; Humans; Kinetics; Models, Chemical; Mutagenesis, Site-Directed; Oxidation-Reduction; Phenacetin; Protein Binding; Structure-Activity Relationship; Substrate Specificity | 2001 |
Investigation of allosteric linkages in the regulation of tryptophan synthase: the roles of salt bridges and monovalent cations probed by site-directed mutation, optical spectroscopy, and kinetics.
Topics: Alanine; Allosteric Regulation; Asparagine; Aspartic Acid; Cations, Monovalent; Deuterium; Dimerization; Enzyme Activation; Kinetics; Lysine; Multienzyme Complexes; Mutagenesis, Site-Directed; Potassium; Quaternary Ammonium Compounds; Salmonella typhimurium; Salts; Sodium; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Threonine; Titrimetry; Tryptophan Synthase | 2001 |
Deuterium isotope effects during carbon-hydrogen bond cleavage by trimethylamine dehydrogenase. Implications for mechanism and vibrationally assisted hydrogen tunneling in wild-type and mutant enzymes.
Topics: Aspartic Acid; Carbon; Deuterium; Flavins; Histidine; Hot Temperature; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Methylamines; Models, Chemical; Oxidoreductases, N-Demethylating; Tyrosine | 2001 |
Inter- and intra-molecular migration of peptide amide hydrogens during electrospray ionization.
Topics: Algorithms; Amides; Aspartic Acid; Deuterium; Fourier Analysis; Hydrogen; Oligopeptides; Phenylalanine; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2001 |
Active site residues of glutamate racemase.
Topics: Amino Acid Isomerases; Amino Acid Sequence; Asparagine; Aspartic Acid; Bacterial Proteins; Binding Sites; Deuterium; Glutamic Acid; Glutamine; Histidine; Isoenzymes; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; Sequence Alignment | 2001 |
Beta D305A mutant of tryptophan synthase shows strongly perturbed allosteric regulation and substrate specificity.
Topics: Alanine; Allosteric Regulation; Aniline Compounds; Aspartic Acid; Benzimidazoles; beta-Alanine; Catalysis; Deuterium; Enzyme Activation; Hydroxylamines; Indoles; Kinetics; Multienzyme Complexes; Mutagenesis, Site-Directed; Pyruvic Acid; Salmonella typhimurium; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Substrate Specificity; Titrimetry; Tryptophan Synthase | 2001 |
Alternative substrates for malic enzyme: oxidative decarboxylation of L-aspartate.
Topics: Animals; Aspartic Acid; Decarboxylation; Deuterium; Hydrogen-Ion Concentration; Kinetics; Malate Dehydrogenase; Substrate Specificity; Swine; Tartrates | 2002 |
Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction.
Topics: Alanine; Aspartic Acid; Binding Sites; Catalysis; Circular Dichroism; Cysteine Synthase; Deuterium; Hydrogen Bonding; Kinetics; Mutagenesis, Site-Directed; Pyridines; Pyridoxal Phosphate; Serine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Substrate Specificity | 2003 |
Synthesis of deuterium derivatives of L-aspartic acid.
Topics: Aspartic Acid; Deuterium; Enzymes | 1962 |
THE STEREOCHEMISTRY OF THE GLUTAMATE MUTASE REACTION.
Topics: Aspartic Acid; Bromine; Chemical Phenomena; Chemistry; Chloramines; Clostridium; Deuterium; Glutamates; Hydrogen; Intramolecular Transferases; Isomerases; Metabolism; Proteus; Research; Succinates | 1964 |
THE MECHANISM OF THE BETA-METHYLASPARTASE REACTION.
Topics: Ammonia-Lyases; Aspartic Acid; Calcium; Chemical Phenomena; Chemistry; Deuterium; Enzyme Inhibitors; Hydrogen; Hydrogen-Ion Concentration; Ions; Lyases; Magnesium; Research; Silver; Sulfhydryl Compounds | 1964 |
A PROTON MAGNETIC RESONANCE STUDY OF THE STEREOCHEMISTRY OF THE METHYLASPARTATE AMMONIA-LYASE REACTION.
Topics: Ammonia; Ammonia-Lyases; Aspartic Acid; Chemistry Techniques, Analytical; Deuterium; Fumarates; Hydrolases; Lyases; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malates; Protons; Research | 1964 |
Comparison of enzymatic and non-enzymatic nitroethane anion formation: thermodynamics and contribution of tunneling.
Topics: Acetates; Anions; Aspartic Acid; Catalysis; Deuterium; Dioxygenases; Enzymes; Ethane; Indicators and Reagents; Kinetics; Nitroparaffins; Oxygenases; Phosphates; Temperature; Thermodynamics | 2004 |
Computational investigation and hydrogen/deuterium exchange of the fixed charge derivative tris(2,4,6-trimethoxyphenyl) phosphonium: implications for the aspartic acid cleavage mechanism.
Topics: Amino Acid Sequence; Aspartic Acid; Computational Biology; Cyclotrons; Deuterium; Hydrogen; Molecular Sequence Data; Organophosphorus Compounds; Peptides; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared | 2005 |
Biosynthetic study of FR-900848: origin of the aminodeoxynucleoside part.
Topics: Antifungal Agents; Aspartic Acid; Carbon Isotopes; Cyclopropanes; Deuterium; Magnetic Resonance Spectroscopy; Molecular Structure; Nucleosides; Ribose; Streptomycetaceae | 2006 |
The effect of deuteration on protein structure: a high-resolution comparison of hydrogenous and perdeuterated haloalkane dehalogenase.
Topics: Aspartic Acid; Binding Sites; Catalysis; Crystallization; Crystallography, X-Ray; Deuterium; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrolases; Protein Conformation; X-Ray Diffraction; Xanthobacter | 2007 |
Protonation and hydrogen bonding of Ca2+ site residues in the E2P phosphoenzyme intermediate of sarcoplasmic reticulum Ca2+-ATPase studied by a combination of infrared spectroscopy and electrostatic calculations.
Topics: Animals; Aspartic Acid; Calcium; Deuterium; Glutamic Acid; Hydrogen Bonding; Hydrogen-Ion Concentration; Ligands; Protein Conformation; Protons; Rabbits; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Spectrophotometry, Infrared; Static Electricity; Water | 2008 |
Switching binding sites: low-temperature NMR studies on adenosine-aspartic acid interactions.
Topics: Adenosine; Aspartic Acid; Binding Sites; Chlorofluorocarbons, Methane; Deuterium; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Structure; Temperature | 2007 |
Roles of histidines 154 and 189 and aspartate 139 in the active site of serine acetyltransferase from Haemophilus influenzae.
Topics: Amino Acid Substitution; Aspartic Acid; Binding Sites; Catalysis; Crystallography, X-Ray; Deuterium; Haemophilus influenzae; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Serine O-Acetyltransferase; Solvents | 2008 |
Structural changes due to the deprotonation of the proton release group in the M-photointermediate of bacteriorhodopsin as revealed by time-resolved FTIR spectroscopy.
Topics: Aspartic Acid; Bacteriorhodopsins; Carbon Radioisotopes; Deuterium; Halobacterium salinarum; Hydrogen-Ion Concentration; Models, Molecular; Photochemistry; Protein Structure, Secondary; Protons; Schiff Bases; Spectroscopy, Fourier Transform Infrared; Tyrosine | 2008 |
Characterization of salt bridges to lysines in the protein G B1 domain.
Topics: Aspartic Acid; Bacterial Proteins; Deuterium; Escherichia coli; Glutamic Acid; Hydrogen-Ion Concentration; Lysine; Nerve Tissue Proteins; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Tertiary; Quantum Theory; Salts; Streptococcus | 2009 |
Almost all enteral aspartate is taken up in first-pass metabolism in enterally fed preterm infants.
Topics: Aspartic Acid; Breath Tests; Carbon Dioxide; Carbon Isotopes; Deuterium; Energy Metabolism; Enteral Nutrition; Humans; Indicator Dilution Techniques; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Infusions, Intravenous; Intestinal Absorption; Kinetics; Sodium Bicarbonate; Splanchnic Circulation | 2010 |
Hydrogen tunneling in adenosylcobalamin-dependent glutamate mutase: evidence from intrinsic kinetic isotope effects measured by intramolecular competition.
Topics: Aspartic Acid; Cobamides; Deoxyadenosines; Deuterium; Hydrogen; Intramolecular Transferases; Kinetics; Models, Molecular; Temperature; Thermodynamics | 2010 |
An economical method for production of (2)H, (13)CH3-threonine for solution NMR studies of large protein complexes: application to the 670 kDa proteasome.
Topics: Aspartic Acid; Biochemistry; Carbon Isotopes; Cost-Benefit Analysis; Deuterium; Isotope Labeling; Magnetic Resonance Spectroscopy; Molecular Weight; Multiprotein Complexes; Proteasome Endopeptidase Complex; Solutions; Thermoplasma; Threonine | 2012 |
Stereoselective synthesis of deuterium-labeled (2S)-cyclohexenyl alanines, biosynthetic intermediates of cinnabaramide.
Topics: Alanine; Alkynes; Aspartic Acid; Cyclohexenes; Deuterium; Lactones; Molecular Structure; Stereoisomerism | 2012 |
Thalamic metabolic abnormalities in patients with Huntington's disease measured by magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Case-Control Studies; Creatine; Deuterium; Dipeptides; Female; Glycerylphosphorylcholine; Humans; Huntington Disease; Magnetic Resonance Spectroscopy; Male; Middle Aged; Motor Activity; Phosphocreatine; Phosphorylcholine; Thalamic Diseases; Thalamus; Trinucleotide Repeats; Young Adult | 2013 |
Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification-Structure-Function Correlations by Hydrogen-Deuterium Exchange Mass Spectrometry.
Topics: Animals; Antibodies, Monoclonal; Antibody Affinity; Antigen-Antibody Reactions; Aspartic Acid; CHO Cells; Complementarity Determining Regions; Cricetinae; Cricetulus; Deuterium; Deuterium Exchange Measurement; Enzyme-Linked Immunosorbent Assay; Hydrogen; Isomerism; Kinetics; Mass Spectrometry; Methionine; Oxidation-Reduction; Protein Structure, Tertiary; Recombinant Proteins | 2016 |
Stereoselective Deuteration in Aspartate, Asparagine, Lysine, and Methionine Amino Acid Residues Using Fumarate as a Carbon Source for Escherichia coli in D
Topics: Amino Acids; Asparagine; Aspartic Acid; Carbon; Culture Media; Deuterium; Escherichia coli; Fumarates; Humans; Lysine; Methionine; Models, Molecular; Mutant Proteins; NIMA-Interacting Peptidylprolyl Isomerase; Stereoisomerism | 2017 |
Kinetics and Mechanism of Aspartic Acid Adsorption and Its Explosive Decomposition on Cu(100).
Topics: Acetonitriles; Adsorption; Aspartic Acid; Copper; Deuterium; Kinetics; Stereoisomerism | 2019 |