aspartic acid has been researched along with asparagine in 1188 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 434 (36.53) | 18.7374 |
| 1990's | 277 (23.32) | 18.2507 |
| 2000's | 296 (24.92) | 29.6817 |
| 2010's | 150 (12.63) | 24.3611 |
| 2020's | 31 (2.61) | 2.80 |
| Authors | Studies |
|---|---|
| Akamatsu, M; Asao, M; Fujita, T; Iwamura, H | 1 |
| Abeles, RH; Foxman, BM; Stern, AM; Tashjian, AH | 1 |
| Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H | 1 |
| Halsall, DM | 1 |
| Hara, TJ | 2 |
| Cooney, DA; Homan, ER; Jayaram, HN; Milman, HA; Rosenbluth, RJ | 1 |
| Bonaventura, C; Bonaventura, J; Ferruzzi, G; Fox, J; McCurdy, PR; Moo-Penn, WF; Sullivan, B | 1 |
| Johnson, MH; Jue, DL; Moo-Penn, WF; Schmidt, RM; Therrell, B; Wilson, SM | 1 |
| Kuromizu, K; Maeda, H | 1 |
| Charache, S; Fox, J; Hathaway, P; Jessop, M; Kazazian, H; McCurdy, P; van Beneden, R; Winslow, R | 1 |
| Desai, JD; Pazoutová, S; Rehácek, Z; Sajdl, P | 1 |
| Dineen, RW; Gray, DO | 1 |
| Applebee, S; Cooney, DA; Milman, HA | 1 |
| Galaev, IuV; Kulikova, AI | 1 |
| Katze, JR | 2 |
| Bagaglio, JF; Mokotoff, M; Parikh, BS | 1 |
| Bachrach, HL; Matheka, HD | 1 |
| Kafkewitz, D | 1 |
| Cohen-Solal, M; Manesse, B; Rosa, J; Thillet, J | 1 |
| Denham, DA; Hebert, CN; Lesslie, IW | 1 |
| Dunlop, PC; Roon, RJ | 1 |
| Korus, RA; O'Driscoll, KF; Ohnuma, T; Walczack, IM | 1 |
| Glass, J; Pelzig, M | 1 |
| Netrval, J | 1 |
| Cooney, DA; Jayaram, HN | 1 |
| McKerrow, JH | 1 |
| Lamm, ME; Purkayastha, S; Rao, CV | 1 |
| Johnson, MH; Jue, DL; Moo-Penn, WF; Patchen, LC | 1 |
| Hageman, JJ; Koomen, GJ; Pandit, UK; Wanner, MJ | 2 |
| Rimpler, M; Robinson, DV | 1 |
| Johnson, MH; Moo-Penn, WF; Therrell, BL | 1 |
| Ala, F; Mostafavi, I; Rahbar, S | 1 |
| Hossmann, KA; Kawakami, S; Kleihues, P; Kobayashi, K | 1 |
| Brubaker, RR; Dreyfus, LA | 1 |
| Holdeman, LV; Smibert, RM | 1 |
| Bernath, FR; Joyeuse, R; Olanoff, LS; Venkatasubramanian, K | 1 |
| Fukuba, Y; Matsuoka, M; Miyaji, T; Ohba, Y; Takeda, I | 1 |
| Gravely, M; Harris, H; Huisman, TH; Lam, H; Wilson, JB | 1 |
| Mantle, PG; Nisbet, LJ | 1 |
| Spaeth, AE; Windmueller, HG | 1 |
| Moule, ML; Yip, CC | 1 |
| Barbeau, A; Beroniade, V; Breton, G; Geoffroy, G; Lemieux, B; Melançon, S; Shapcott, D | 1 |
| Bechtel, KC; Johnson, MH; Jue, DL; Moo-Penn, WF; Schmidt, RM | 1 |
| von Jagow, G | 1 |
| Aledort, L; Patel, I; Puszkin, EG | 1 |
| Airoldi, LP; Doonan, S | 1 |
| Dolowy, WC; Holcenberg, JS; Tang, E | 1 |
| Crain, PF; Harada, F; Kasai, H; Liehr, JG; McCloskey, JA; Nishimura, S; Oashi, Z; Oppenheimer, NJ; von Minden, DL | 1 |
| Trayhurn, P | 1 |
| Ager, JA; Darbre, PD; Huntsman, RG; Lehmann, H; Lorkin, PA; Vella, F | 1 |
| Fillios, LC; Frankel, DL; Newburg, DS | 1 |
| DeFrancesco, L; Scheffler, IE; Werntz, D | 1 |
| Mahdavi, N; Mostafavi, I; Nowzari, G; Rahbar, S | 1 |
| Chellemi, F | 1 |
| Aseeva, KB; Evstigneeva, ZG; Kretovich, VL; Martynova, EM | 1 |
| Folbergrová, J; Norberg, K; Quistorff, B; Siesjö, BK | 1 |
| Atkins, RJ; Casey, R; Hosty, TS; Lehmann, H; Lorkin, PA; Nagai, K; Schneider, RG; Tomlin, G | 1 |
| Ali, M; Capindale, JB | 1 |
| Fox, SW; Harada, K | 1 |
| Ferroni, R; Guggi, A; Rocchi, R; Tomatis, R | 1 |
| Elbaum, D; Harrington, J; Nagel, RL; Roth, EF | 1 |
| Dudásová, S; Grancicová, E | 1 |
| Bengström, M; Hongell, V; Kiuru, S; Mustonen, E; Palo, J; Paunio, T; Peltonen, L; Syvänen, AC | 1 |
| Erman, JE; Kraut, J; Mauro, JM; Miller, MA; Vitello, LB | 1 |
| Crespeau, H; Ferri, G; Galliano, M; Minchiotti, L; Porta, F; Rochu, D; Stoppini, M | 1 |
| Dauth, J; Nkhumeleni, FS; Pitout, MJ; Raubenheimer, EJ; Smith, PD; van Heerden, WF | 1 |
| Akbarali, H; Horstman, DA; Limbird, LE; Surprenant, A | 1 |
| Rupitz, K; Trimbur, D; Warren, RA; Withers, SG | 1 |
| Addo-Yobo, F; Aracil, J; Casillas, JL; Kenney, CN; Martínez, M | 1 |
| Lanyi, JK; Maeda, A; Sasaki, J; Shichida, Y | 1 |
| Carlson, H; Hillered, L; Ronne-Engström, E; Ungerstedt, U | 1 |
| Hardy, LW; Nalivaika, E | 1 |
| Bongers, J; Campbell, RM; Felix, AM; Heimer, EP; Lambros, T; Pan, YC | 1 |
| Benkovic, SJ; Gibbs, RA; Taylor, S | 1 |
| de Pater, BS; Díaz, CL; Hoedemaeker, FJ; Kijne, JW; Lugtenberg, BJ; van Eijsden, RR | 1 |
| Heyn, MP; Khorana, HG; Marti, T; Otto, H; Rösselet, SJ | 1 |
| Long, GL; Nelson, RM | 1 |
| Benz, EJ; Gupta, KC; Inaba, M; Kuwabara, M; Maede, Y; Takahashi, T | 1 |
| Liu, L; Santi, DV | 1 |
| Gutteridge, S; Schneider, G; Söderlind, E | 1 |
| el-Fakahany, EE; Hu, J; Lee, NH | 1 |
| Chang, M; Fornés, J; Lanyi, JK; Needleman, R; Ni, B; Váró, G; White, SH | 1 |
| Wright, HT | 1 |
| Flott, B; Seifert, W | 1 |
| deMel, VS; Doscher, MS; Edwards, BF; Martin, PD | 1 |
| Asselin, BL; Blakley, RL; Cohen, HJ; Coppola, DJ; Kende, AS; Lorenson, MY; Whitin, JC | 1 |
| Jenster, G; Kaufman, M; Kuiper, GG; Liao, S; Ris-Stalpers, C; Romalo, G; Rosenfield, RL; Sai, T; Trifiro, MA; van Rooij, HC | 1 |
| Emmons, T; Takemoto, L | 1 |
| Clarke, S; Lowenson, JD | 1 |
| Friedman, PA; Long, GL; Nelson, RM; VanDusen, WJ | 1 |
| de Lamotte-Guery, F; Decottignies, P; Jacquot, JP; Miginiac-Maslow, M; Minard, P; Stein, M | 1 |
| Betlach, MC; Kliger, DS; Miercke, LJ; Milder, SJ; Shand, RF; Stroud, RM; Thorgeirsson, TE | 1 |
| Cederholm, MT; Doscher, MS; Lee, L; Stuckey, JA | 1 |
| McAlister-Henn, L; Steffan, JS | 1 |
| Iyer, RK; Lim, HM; Pène, JJ | 1 |
| Anderson, DE; Dao-pin, S; Matthews, BW; Nicholson, H | 1 |
| Stenflo, J | 1 |
| Goetsch, L; Grange, J; Hamedi-Sangsari, F; Malley, S; Navarro, C; Thomasset, N; Tournaire, R; Vila, J | 1 |
| Kyriakidis, DA; Triantafillou, DJ; Tsavdaridis, IK | 1 |
| Fukui, K; Gottschal, JC; Kato, K; Ohta, H | 1 |
| Nathans, J | 1 |
| Asano, T; Ishihara, H; Katagiri, H; Lin, JL; Oka, Y; Shibasaki, Y; Tsukuda, K; Yazaki, Y | 1 |
| Takemoto, Y | 1 |
| Pullman, TN; Refetoff, S; Sobieszczyk, P; Takeda, K; Waltz, MR | 1 |
| Ishii, S | 1 |
| Dusart, J; Frère, JM; Jacob, F; Joris, B; Lepage, S | 1 |
| Erman, JE; Kraut, J; Mauro, JM; Satterlee, JD | 1 |
| Horn, V; Shirvanee, L; Yanofsky, C | 1 |
| Gibbs, MR; Leslie, AG; Moody, PC | 1 |
| Emmons, T; Granstrom, D; Takemoto, L | 1 |
| Bardet, J; de Blois, MC; Kamoun, P; Lejeune, J; Parvy, P; Peeters, M; Rabier, D; Rethoré, MO | 1 |
| Chen, SS; Huisman, TH; Webber, BB; Wilson, JB | 1 |
| Shapira, G; Shapira, R; Wilkinson, KD | 1 |
| Harper, JW; Vallee, BL | 1 |
| Gleed, JH; Hendy, GN; Kimura, T; O'Riordan, JL; Sakakibara, S | 1 |
| Clissold, PM; Lachmann, PJ; Poznansky, MC | 2 |
| Clarke, S; Ota, IM | 1 |
| Khorana, HG; Marinetti, T; Marti, T; Mogi, T; Subramaniam, S | 1 |
| Gerwert, K; Hess, B; Oesterhelt, D; Soppa, J | 1 |
| Bamberg, E; Butt, HJ; Oesterhelt, D; Soell, C; Tittor, J | 1 |
| Boxer, SG; Gray, HB; Varadarajan, R; Zewert, TE | 1 |
| Daly, MP; Demediuk, P; Faden, AI | 1 |
| Bell, EF; Filer, LJ; Stegink, LD; Tephly, TR; Ziegler, EE | 1 |
| Clarke, DM; Inesi, G; Leberer, E; Loo, TW; MacLennan, DH; Maruyama, K | 1 |
| Meessen, S; Oesterhelt, D; Otomo, J; Soppa, J; Straub, J; Tittor, J | 1 |
| Ahl, PL; Berkowitz, S; Duñach, M; Khorana, HG; Marti, T; Mogi, T; Rothschild, KJ; Stern, LJ | 1 |
| Leanderson, T; Nose, M | 1 |
| Harris, GW; Howlin, B; Moss, DS | 1 |
| Drachev, LA; Heyn, MP; Holz, M; Kaulen, AD; Khorana, HG; Mogi, T; Otto, H; Skulachev, VP | 1 |
| Clarke, S; Stephenson, RC | 1 |
| Aswad, DW; Basa, LJ; Hancock, WS; Johnson, BA; Shirokawa, JM; Spellman, MW | 1 |
| Callaghan, LP; Chambers, PL | 1 |
| Andrews, J; Arnold, JR; Birdsall, B; Feeney, J; Jimenez, MA; Roberts, GC; Thomas, JA | 1 |
| Bennett, CD; Friedman, PA; Musson, DG; Przysiecki, CT; Ramjit, HG; Staggers, JE; Stern, AM | 1 |
| Ohlin, AK; Owen, WG; Schneider, WJ; Stenflo, J | 1 |
| Chung, FZ; Fraser, CM; Venter, JC; Wang, CD | 1 |
| Takizawa, T; Yoshida, A | 1 |
| Joy, K; Ta, TC | 1 |
| Bell, EF; Brummel, MC; Filer, LJ; Krause, WL; Stegink, LD; Wolf-Novak, LC; Ziegler, EE | 1 |
| Bowen, DM; Esiri, MM; Francis, PT; Hunt, A; Lowe, SL; Najlerahim, A; Palmer, AM; Patel, AJ; Procter, AW; Stratmann, GC | 1 |
| Candelore, MR; Dixon, RA; Hill, WS; Rands, E; Sigal, IS; Strader, CD | 1 |
| Nishimura, K; Noda, S; Ohta, M; Oyama, N; Shiota, M; Sogabe, N; Sugano, T | 1 |
| Chance, WT; Enrione, EB; Popp, MB; Wagner, SC | 1 |
| Clarke, S; Lowenson, J | 1 |
| Cullis, PM; Kleanthous, C; Lewendon, A; Murray, IA; Shaw, WV | 1 |
| Craik, CS; Finer-Moore, J; Fletterick, RJ; Hamlin, R; Rutter, WJ; Sprang, S; Standing, T; Stroud, RM; Xuong, NH | 1 |
| Crechet, JB; De Vendittis, E; Fasano, O; Feger, G; Parmeggiani, A; Vitelli, A; Zahn, R | 1 |
| Kantrowitz, ER; Middleton, SA | 1 |
| Appleman, JR; Blakley, RL; Howell, EE; Kraut, J; Kühl, M | 1 |
| Craik, CS; Largman, C; Roczniak, S; Rutter, WJ | 1 |
| Hwang, YW; Miller, DL | 1 |
| LeMaster, DM | 1 |
| Hodges, RS; Marsden, BJ; Sykes, BD | 1 |
| Clarke, S | 2 |
| Aberth, W; Brown, CF; DiAugustine, RP; Ferrua, CM; Gibson, BW; Kelly, M; Tomooka, Y; Walker, M | 1 |
| Clark, DP; Winkelman, JW | 1 |
| Blakley, RL; Howell, EE; Kraut, J; London, RE; Warren, MS | 1 |
| Clarke, S; Ding, L; Ota, IM | 1 |
| Graves, DJ; Liao, CX; Luo, SQ; McClelland, JF | 1 |
| Anchustegui, M; Arends, T; Castillo, O; Garlín, G; Maleh, Y; Salazar, R | 1 |
| Brkljac, O; Kovacević, Z; Lelas, S; Popović, J | 1 |
| Brunauer, LS; Clarke, S | 2 |
| Imoto, T; Kuroki, R; Moriyama, T; Yamada, H | 1 |
| Miyamae, Y; Ohta, T; Sugano, T; Tarui, A | 1 |
| Glazer, AN; Klotz, AV; Leary, JA | 1 |
| Clarke, S; Geiger, T | 1 |
| Ami, M; Arai, Y; Igarashi, M; Miyaji, T; Nakashima, M; Ohba, Y; Sanada, C; Tsukahara, M | 1 |
| Arous, N; Bardakjian, J; Blouquit, Y; Bohn, B; Galacteros, F; Leclerc, L; Oules, O; Poyart, C; Rafaillat, D; Rosa, J | 1 |
| Chino, N; Kimura, T; Kumagaye, KY; Sakakibara, S; Takai, M | 1 |
| Abuchowski, A; Davis, FF; Hansen, S; Perry, TL; Wright, JM | 1 |
| Chen, SS; Huisman, TH; Kutlar, A; Webber, BB; Wilson, JB | 1 |
| Mircevová, L; Mokrý, Z; Simonová, A | 1 |
| Gerstenbrand, F; Gründig, E; Schedl, R; Simanyi, M; Weiss, H | 1 |
| Folbergrová, J; Ljunggren, B; Norberg, K; Siesjö, BK | 1 |
| Bergenstal, R; Burg, A; Cooney, DA; Fleischman, R; Morrison, R; Yavelow, J; Zlotoff, R | 1 |
| Jaton, JC | 1 |
| Pliskowá, M | 1 |
| Jenner, FA; Merskey, H; Pollitt, RJ | 1 |
| Melchers, F | 1 |
| Baikie, AG; Dartnall, JA | 1 |
| Tener, GM; White, BN | 1 |
| Costas-Martinez, C; Hall, WH; Lyon, RH | 1 |
| Benuck, M; Lajtha, A; Stern, F | 2 |
| Miyazawa, Y; Sekine, T; Yamaguchi, M | 1 |
| Cohen, L; Eagle, H; Levy, M; Washington, CL | 1 |
| Biron, P | 1 |
| Orr, GR; Patterson, MK | 2 |
| Barbarino, F; Cotutiu, C; Nicoara, A; Tapalaga, D | 1 |
| Barrett, JD; Sambhi, MP | 1 |
| Chen, YT; Norton, SJ | 1 |
| Fontenelle, LJ; Henderson, JF | 1 |
| Kojima, Y; Wacker, WE | 1 |
| Gregerman, RI; Kowatch, MA; Weaver, T | 1 |
| Oda, KI; Sekiya, T | 1 |
| Chou, TC; Handschumacher, RE | 1 |
| McConnell, HM; Ogata, RT | 2 |
| Bohnert, JL; Taniuchi, H | 1 |
| Blattmann, P; Rétey, J | 1 |
| Laycock, MV | 1 |
| Baldassare, JJ; Bunn, HF; Ho, C; Lindstrom, TR | 1 |
| Buchanan, JM | 1 |
| Holmquist, R; Jukes, TH | 1 |
| Crippa, PR; Tedeschi, RA; Vecli, A | 1 |
| Yoshida, A | 1 |
| Litwack, G; Miller, JE | 1 |
| Langer, BW; Smith, WJ; Theodorides, VJ | 1 |
| Martin, DW; Murphy, B | 1 |
| Anderson, R; Berry, E; Carrell, RW; Owen, MC | 1 |
| Pollitt, RJ; Pretty, KM | 2 |
| Borgström, B; Erlanson, C; Sternby, B | 1 |
| el-Din, SM; Foda, MS; Khafagy, EZ | 1 |
| Mehler, AH; Midelfort, CF | 1 |
| Castillo, CL; Mayer, A; Ogawa, S; Shulman, RG | 1 |
| Harada, F; Nishimura, S | 1 |
| Citri, N; Kitron, N; Zyk, N | 1 |
| Holland, JF; Meyer, P; Ohnuma, T | 1 |
| Jaenicke, L; Menge, U | 1 |
| Homer, RB | 1 |
| Hegeman, GD; Holden, JT; Kenyon, CN; Utech, NM | 1 |
| Lewis, SD; Shafer, JA | 1 |
| Anthony, C; Drabble, WT; Robinson, JH | 2 |
| Murthy, MR; Roux, H; Thenot, JP | 1 |
| Willis, RC; Woolfolk, CA | 1 |
| Parrott, CL; Shifrin, S | 1 |
| Halpern, YS | 1 |
| Pittsyn, OB | 1 |
| Eĭdus, IA; Melle, GI; Orovere, MI; Shprunka, IK; Zhagat, RA | 1 |
| Schindler, PW; Zähner, H | 1 |
| Deutsch, HF; Lin, KD | 1 |
| Boyer, ML; Boyer, SH; Marr, K; Noyes, AN | 1 |
| Peters, JH; Smith, CC | 1 |
| Anderson, PJ; Gibson, D | 1 |
| Daill, M; Fink, E; Kronberger, L; Schindler, R | 1 |
| Berezov, TT; Hisamov, GZ; Zanin, VA | 1 |
| Ali, A; Faesel, JH; Sarantakis, D; Stevenson, D; Weinstein, B | 1 |
| Bondarenko, TI; Krichevskaia, AA | 1 |
| Cooney, DA; Milman, HA | 1 |
| Harper, AE; Maruyama, K; Sunde, ML | 1 |
| Büchner, M; Hofmann, F; Scheid, P | 1 |
| Bodor, A; Ivanof, A; Serban, D | 1 |
| Betz, AL; Gilboe, DD | 1 |
| Handschumacher, RE; Woods, JS | 2 |
| Boucher, Y; Lachance, RA; Paquin, R; Willemot, C | 1 |
| Kihara, T; Kurimoto, K; Shimada, M; Watanabe, M | 1 |
| Kono, M; Yamashina, I | 1 |
| Adibi, SA; Amin, PM; Modesto, TA; Morse, EL | 1 |
| Kopple, JD; Shinaberger, JH; Swendseid, ME; Umezawa, CY | 1 |
| Minton, AP | 1 |
| Streeter, JG | 1 |
| Cameron, T; Cooney, DA; Homan, E; Schaeppi, U | 1 |
| Cline, TR; Crosby, LO | 1 |
| Blackwell, RQ; Jim, RT; Liu, CS; Tan, TG; Wang, CL; Weng, MI | 1 |
| Gurd, FR; Keim, P; Marshall, RC; Morrow, JS; Vigna, RA | 1 |
| Chibata, I; Ito, H; Kishi, T | 1 |
| Nair, PM; Shirsat, SG | 1 |
| Berezov, TT; Evseev, LP; Khisamov, GZ; Zanin, VA | 1 |
| Colofiore, J; Morrow, J; Patterson, MK | 1 |
| Dolowy, WC; Fitzmaurice, MA; Holcenberg, JS; Riley, V; Roberts, J; Spackman, D | 1 |
| Murthy, MR; Roux, H | 1 |
| Wilde, KM | 1 |
| Goodman, D; Kafkewitz, D | 1 |
| Allam, ME; Yusef, HM | 1 |
| Broome, JD | 2 |
| Holcenberg, JS; Pease, J | 1 |
| Berger, H; Yanofsky, C | 1 |
| Cedar, H; Schwartz, JH | 2 |
| Kirschbaum, J; Ratych, OT; Wriston, JC | 1 |
| Berk, B; Robison, RS | 1 |
| Laboureur, P | 1 |
| Freeman, A; Holland, JF; Ohnuma, T; Sinks, LF | 1 |
| Milner, L; Prusiner, S | 1 |
| Dworak, JE; Ryan, WL | 1 |
| Canellos, GP; Haskell, CM | 3 |
| Berger, H; Brammar, WJ; Yanofsky, C | 1 |
| Bauer, S; Kirchner, H | 1 |
| Kessel, D | 1 |
| Hydén, H | 1 |
| Balis, ME | 1 |
| Jenkins, WT; Martinez-Carrion, M | 1 |
| Kinoshita, Y; Nemoto, G; Ujiie, A | 1 |
| Kilburn, JO; Kubica, GP; Stottmeier, KD | 1 |
| Castric, PA; Strobel, GA | 1 |
| Buu-Hoï, NP; Hauspie, R; Lambelin, G; Nicolle, J | 1 |
| Berridge, BJ; Chao, WR; Cummings, JG; Lin, SC; Peters, JH | 1 |
| Holden, JT; Reid, KG; Utech, NM | 1 |
| Hong, B; Solie, TN; Tu, AT | 1 |
| Cylwik, B; Nowak, HF | 1 |
| Carpenter, FH; Howard, JB | 1 |
| Allison, JP; Davidson, L; Gutierrez-Hartman, A; Kitto, GB | 1 |
| Carmo, RJ; Leao, AA | 1 |
| Hafez, ES; Jaszczak, S; Kurrie, DA; Moghissi, KS | 1 |
| Davies, MR; Marshall, RD | 1 |
| Husain, I; Norris, RF; Poupard, JA | 1 |
| Mokotoff, M; Parikh, BS | 1 |
| Fujita, S | 1 |
| Niederman, RA; Wolin, MJ | 1 |
| Fothergill, JE; Fothergill, LA; Wiseman, RL | 1 |
| Horowitz, B; Meister, A | 1 |
| Fidler, IJ; Montgomery, PC | 1 |
| Casola, L; Di Matteo, G | 1 |
| Blackwell, RQ; Boon, WH; Liu, CS; Weng, MI | 1 |
| Olson, MS; Schuster, SM | 1 |
| Etheredge, EE; Najarian, JS; Shons, AR | 1 |
| Kinderlerer, JL; Konotey-Ahulu, FI; Lehmann, H; Ringelhann, B | 1 |
| Holt, LA; Milligan, B; Roxburgh, CM | 1 |
| Grossowicz, N; Lichtenstein, N; Schlesinger, M | 1 |
| Gross, W; Ring, K | 1 |
| Parekh, LJ; Ramakrishnan, CV; Sakariah, KK | 1 |
| Maigret, B; Perahia, D; Pullman, B | 1 |
| Cowley, DE; Hough, L; Khan, MY | 1 |
| Blomquist, AT; Cedergren, RJ; Harpp, DN; Hiscock, BF; Tripp, SL | 1 |
| Kotelchuck, D; Scheraga, HA | 1 |
| Faulcon, FM; Lee, WH; Regan, JD; Takeda, S; Vodopick, N | 1 |
| Krzemiński, Z | 1 |
| Brodsky, I; Dimitrov, NV | 1 |
| Chaudhuri, TK; Winchell, HS | 1 |
| Fujita, S; Hanada, M; Imamura, T; Ohta, Y; Yanase, T | 1 |
| Campbell, WF; Levine, AS | 1 |
| Fink, E; Kronberger, L | 1 |
| Benzonana, G; Desnuelle, P; Sémériva, M | 1 |
| Iwainsky, H; Sehrt, I | 1 |
| Bornstein, P | 1 |
| Ajazzi Mancini, M | 1 |
| Aledort, L; Puszkin, E; Puszkin, S | 2 |
| Chen, DM; Harper, AE; Rogers, QR | 1 |
| Fairclough, GF; Metrione, RM; Okuda, Y | 1 |
| Eyl, A; Inagami, T | 1 |
| Tarnok, I | 1 |
| Imada, M; Inouye, M; Tsugita, A | 1 |
| Chen, C; Horecker, BL; Lai, CY | 1 |
| Elliott, KA; Yoshino, Y | 1 |
| Garg, GK; Virupaksha, TK | 1 |
| Cunningham, BA; Edelman, GM; Gottlieb, PD; Rutishauser, U | 1 |
| Baranova, IP; Egorov, NS | 1 |
| Blakeney, AB; Lees, EM | 1 |
| Brunfeldt, K; Halstrom, J; Kovács, K; Schou, O | 1 |
| Austen, BM; Marshall, RD | 1 |
| Dus, K; Erbes, DL; Gunsalus, IC; Katagiri, M; Yu, CA | 1 |
| Astaldi, A; Astaldi, G; Burgio, GR; Krc, I; Micu, D | 1 |
| Dixon, RL; Lee, IP; Woods, JS | 1 |
| Capizzi, RL; Cooney, DA; Handschumacher, RE | 1 |
| Cedar, H; Ehrman, M; Schwartz, JH | 1 |
| Bladen, HA; Cuatrecasas, P; Eanes, ED; Glenner, GG; Harada, M; Isersky, C; Keiser, HR; Page, D | 1 |
| Derr, I; Prager, MD | 1 |
| Hong, BS; Tu, AT | 1 |
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| D'Aquino, S; Di Francesco, A; Mari, M; Pagnotta, E; Ugolini, L | 1 |
| Adams, M; Alves, J; Goueli, S; Hsiao, K; Nashine, V; Patel, R | 1 |
| Barbiroli, A; Bellotti, V; Bolognesi, M; de Rosa, M; Halabelian, L; Ricagno, S | 1 |
| Anstrom, K; Bain, JR; Felker, GM; Hernandez, A; Ilkayeva, O; Kraus, WE; McNulty, S; Muehlbauer, MJ; Newgard, CB; Redfield, M; Shah, SH; Wang, H | 1 |
| Eoh, H; Gao, SJ; Jung, JU; Lee, JJ; Li, T; Lu, C; Ramos da Silva, S; Zhu, Y | 1 |
| Marian, AJ | 1 |
| Danmaliki, GI; Hwang, PM; Liu, PB | 1 |
| Li, G; Lu, CD | 1 |
| Dai, G; Demura, M; Geng, X; Iwasa, T; Kamo, N; Kikukawa, T; Tamogami, J | 1 |
| Carl, A; Goldgur, Y; Shuman, S; Uson, ML | 1 |
| Gao, W; Liu, H; Nie, Z; Rengel, Z; Wang, J; Zhao, P | 1 |
| Liu, H; Nowak, C; Tiwari, A | 1 |
| Helmann, JD; Roistacher, DM; Zhao, H | 1 |
| Chen, H; Feng, Z; Leng, C; Liu, G; Lv, X; Qiao, Y; Sun, J; Zhang, Y | 1 |
| Barber, PS; Cilli, EM; Lopes, AM; Magri, A; Pereira, JFB; Pessoa, A; Soler, MF | 1 |
| Friedrich, MG; Schey, KL; Truscott, RJW; Wang, Z | 1 |
| Brewer, SH; Lee, BU; Maurici, N; Phillips-Piro, CM; Savidge, N | 1 |
| Busch, M; Culp-Hill, R; D'Alessandro, A; Dumont, LJ; Dunham, A; Dzieciatkowska, M; Eisenmesser, EZ; Hansen, KC; Hill, RC; Kanias, T; Nemkov, T; Reisz, JA; Stefanoni, D; Yoshida, T; Zimring, JC | 1 |
| Hay, N; Terry, AR | 1 |
| Darvishi, F; Faraji, N; Shamsi, F | 1 |
| Adam, ML; Cantalice, JCLL; da Silva Lacerda, GR; da Silva, IDG; de Albuquerque, LEF; de Melo, MEB; de Souza Lima, GM; do Nascimento, SC | 1 |
| Gomez, GVB; Lima, CSP; Lourenço, GJ; Moraes, AM; Oliveira, C; Rinck-Junior, JA; Torricelli, C | 1 |
| Kagra, D; Preethi, SP; Sharma, P | 1 |
| Dagogo-Jack, S; Owei, I; Stentz, F; Umekwe, N; Wan, J | 1 |
| Cohen, A; Kupiec, M; Reidman, S; Weisman, R | 1 |
| Fujii, N; Ha, S; Koide, T; Takata, T | 1 |
| Enyedi, KN; Jákli, I; Láng, A; Menyhárd, DK; Mező, G; Perczel, A | 1 |
| Afzal, M; Azeem, F; Muneer, F; Muzammil, S; Nadeem, H; Rasul, I; Siddique, MH; Zubair, M | 1 |
| Deng, L; Ji, F; Jiang, P; Lan, X; Li, L; Xu, C; Yao, P; Zhao, S | 1 |
| Haring, L; Kangro, R; Koch, K; Leppik, L; Parksepp, M; Uppin, K; Vasar, E; Zilmer, M | 1 |
| Fang, ZZ; Feng, XF; Hou, RQ; Luo, HH; Yang, XL | 1 |
| Cabrele, C; Hinterholzer, A; Huber, CG; Regl, C; Schubert, M; Stanojlovic, V | 1 |
| Christofk, HR; Halbrook, CJ; Knott, SRV; Krall, AS; Lyssiotis, CA; Mittelman, SD; Momcilovic, M; Mullen, PJ; Schmid, EW; Shackelford, DB; Surjono, F; Thambundit, A | 1 |
| Bielawski, JP; Cohen, A; Connors, J; Dunn, KA; Forbrigger, Z; Kulkarni, K; Langille, MGI; MacDonald, T; Penny, SL; Rahman, M; Stadnyk, AW; Van Limbergen, J | 1 |
| Cowan, JA; Greve, JM; Pinkham, AM | 1 |
| Banerjee, S; Barroso, C; Coelho, AV; Conde, R; Gaddam, S; Gonçalves, LG; Laires, R; Lamosa, P; Macedo, R; Mande, SC; Matzapetakis, M; Patel, AB; Pineda-Lucena, A; Puchades-Carrasco, L; Rizvi, A; Simões, MJ; Villar, M | 1 |
| Borgo, A; Drögemüller, C; Goepfert, C; Häfliger, IM; Jacinto, JGP; Komáromy, AM; Marchionatti, E; Occelli, LM; Oevermann, A; Paris, JM; Roduit, R; Seefried, FR; Spengeler, M; Stengård, M; Voelter, K; Watté, C; Wolf-Hofstetter, S | 1 |
| Benjelloun, AT; Benzakour, M; El Adnani, Z; El Khabchi, M; Fitri, A; Lahlou, H; Mcharfi, M | 1 |
| Asato, M; Ishikawa, T; Kajitani, K; Kobayashi, T; Kouya, T; Shibata, K; Takahashi, S | 1 |
| Francesco, AD | 1 |
| Brewitz, L; Onisko, BC; Schofield, CJ | 1 |
| Huang, C; Huang, F; Li, B; Lin, D; Wang, S; Xu, C; Zhang, T | 1 |
| Chen, X; Ge, T; He, Z; Wang, J; Yuan, H; Zhang, L | 1 |
| Ates, O; Toker, EB; Yesilbag, K | 1 |
| Jaskolski, M; Karlowski, WM; Loch, JI; Zielezinski, A | 1 |
| Chai, Y; Gong, J; Kai, J; Lin, J; Liu, J; Shu, X; Tang, M; Yang, J; Yang, X; Zhang, W; Zhang, X | 1 |
| Hanada, K; Itatani, Y; Kawada, K; Maekawa, H; Miyoshi, H; Nishikawa, G; Obama, K; Taketo, MM | 1 |
| Almotairy, HM; Almutairi, MM | 1 |
| Guo, J; Han, D; Hu, Y; Li, M; Shi, L; Wei, J; Zhang, T | 1 |
| Bain, J; Colón-Emeric, C; Ilkayeva, O; Lee, RH; Muehlbauer, M; Pieper, C; Wixted, D | 1 |
| Chang, MC; Kilberg, MS; Malut, VR; Merritt, ME; Pierre, GL; Staklinski, SJ | 1 |
| Glatter, T; Guo, K; Liesack, W; Paczia, N | 1 |
| Cai, Y; Deng, Z; Hao, H; Li, S; Shi, C; Song, J; Yang, Q; Zhuang, G | 1 |
| Feng, Y; Jie, Q; Liang, W; Qin, J; Wu, W; Yang, D; Zhi, X | 1 |
| Ferrieri, RA; Noel, R; Powell, A; Schueller, MJ; Waller, S | 1 |
28 review(s) available for aspartic acid and asparagine
| Article | Year |
|---|---|
Non-enzymatic, post-translational, amino acid modifications in ageing. A brief review.
Topics: Aging; Amides; Amino Acids; Animals; Asparagine; Aspartic Acid; Glutamine; Half-Life; Isomerism; Models, Biological; Oligopeptides; Proteins; Rats; Structure-Activity Relationship | 1979 |
Amino acid composition of dentine in permanent human teeth.
Topics: Amino Acids; Asparagine; Aspartic Acid; Dentin; Glutamates; Glutamic Acid; Humans; Hydroxylysine; Lysine | 1992 |
Nonenzymatic deamidation of asparaginyl and glutaminyl residues in proteins.
Topics: Amides; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Glutamates; Glutamic Acid; Glutamine; Humans; Molecular Sequence Data; Protein Processing, Post-Translational | 1991 |
Structure-function relationships of epidermal growth factor modules in vitamin K-dependent clotting factors.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Blood Coagulation Factors; Calcium; Epidermal Growth Factor; Humans; Molecular Sequence Data; Structure-Activity Relationship; Vitamin K | 1991 |
Evolution of gonadotropins in vertebrates.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Biological Evolution; Bufonidae; Follicle Stimulating Hormone; Gonadotropins; Luteinizing Hormone; Molecular Sequence Data; Proline; Sequence Homology, Nucleic Acid; Vertebrates | 1990 |
Does the chemical instability of aspartyl and asparaginyl residues in proteins contribute to erythrocyte aging? The role of protein carboxyl methylation reactions.
Topics: Asparagine; Aspartic Acid; Blood Proteins; Erythrocyte Aging; Humans; Methylation | 1988 |
[Angiotensinases of human plasma].
Topics: Aminopeptidases; Angiotensin II; Asparagine; Aspartic Acid; Edetic Acid; Endopeptidases; Humans; Liver Diseases; Peptide Hydrolases | 1967 |
The amidotransferases.
Topics: Anthranilate Synthase; Asparagine; Aspartic Acid; Binding Sites; Carbamates; Cytosine Nucleotides; Fructosephosphates; Glutamine; Ligases; Liver; Macromolecular Substances; NAD; Organophosphorus Compounds; Protein Conformation; Pyrimidine Nucleotides; Ribose; RNA, Transfer; Transaminases; Xanthines | 1973 |
Genetics of amino acid transport in bacteria.
Topics: Alanine; Amino Acids; Amino Acids, Diamino; Arginine; Asparagine; Aspartic Acid; Biological Transport; Cell Membrane Permeability; Cystine; Energy Metabolism; Escherichia coli; Genes, Regulator; Genetics, Microbial; Glutamates; Glutamine; Glycine; Histidine; Hydroxyproline; Isoleucine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1974 |
Invariant features of globin primary structure and coding of their secondary structure.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Globins; Glycine; Hemoglobins; Histidine; Myoglobin; Proline; Protein Conformation; Serine; Species Specificity; Threonine; Tyrosine | 1974 |
[Biochemistry of asparaginase. Properties of the asparaginase system and biological activity].
Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Enzyme Repression; Glutaminase; Mice; Rabbits; Rats; Ribonucleases | 1969 |
Determination of glutamic and aspartic acids and their amides.
Topics: Aminobutyrates; Ammonia; Asparaginase; Asparagine; Aspartic Acid; Carboxy-Lyases; Chromatography, Ion Exchange; Chromatography, Paper; Colorimetry; Electrophoresis, Paper; Glutamate Dehydrogenase; Glutamates; Glutamine; Indicators and Reagents; L-Lactate Dehydrogenase; Leucyl Aminopeptidase; Lyases; Manometry; Methods; Papain; Pyruvates; Transaminases | 1971 |
Membrane cholesterol, tumorigenesis, and the biochemical phenotype of neoplasia.
Topics: Acetates; Animals; Asparagine; Aspartic Acid; Biological Transport, Active; Cell Division; Cell Membrane Permeability; Cholesterol; Citric Acid Cycle; Electron Spin Resonance Spectroscopy; Glucose; Glutamates; Glutamic Acid; Glutamine; Lipid Bilayers; Liver Neoplasms, Experimental; Membrane Lipids; Mitochondria; Mitochondria, Liver; Models, Biological; Neoplasms; Oxygen Consumption; Phenotype; Purines; Pyrimidines; Pyruvates; Pyruvic Acid; Surface Properties | 1981 |
In vivo chemical modification of proteins (post-translational modification).
Topics: Amino Acids; Animals; Arginine; Asparagine; Aspartic Acid; Glutamates; Glutamine; Histidine; Hydroxylysine; Lysine; Phenylalanine; Proline; Protein Biosynthesis; RNA, Transfer, Amino Acyl; Serine; Threonine; Tryptophan; Tyrosine | 1981 |
The denaturation and degradation of stable enzymes at high temperatures.
Topics: Asparagine; Aspartic Acid; Enzymes; Hot Temperature; Models, Chemical; Protein Conformation; Protein Denaturation | 1996 |
Metabolite and light regulation of metabolism in plants: lessons from the study of a single biochemical pathway.
Topics: Amino Acids, Dicarboxylic; Arabidopsis; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Carbon; Gene Expression Regulation, Plant; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Light; Nitrogen; Receptors, Glutamate | 2001 |
Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis.
Topics: Alcoholism; Asparagine; Aspartic Acid; Gene Frequency; Genetic Predisposition to Disease; Humans; Polymorphism, Single Nucleotide; Receptors, Opioid, mu; Risk; Substance-Related Disorders | 2006 |
Amino acid catabolic pathways of lactic acid bacteria.
Topics: Alanine; Amino Acids; Amino Acids, Aromatic; Amino Acids, Branched-Chain; Asparagine; Aspartate Ammonia-Lyase; Aspartic Acid; Biodegradation, Environmental; Fermentation; Food Microbiology; Glutamate Decarboxylase; Glutamic Acid; Glutamine; Histidine; Lactic Acid; Lactobacillus; Proline | 2006 |
Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization.
Topics: Amides; Asparagine; Aspartic Acid; Chemistry, Pharmaceutical; Drug Compounding; Excipients; Hydrogen-Ion Concentration; Isomerism; Particle Size; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins; Temperature | 2006 |
Nonenzymatic posttranslational protein modifications in ageing.
Topics: Aging; Asparagine; Aspartic Acid; Deamination; Glycation End Products, Advanced; Humans; Maillard Reaction; Mass Spectrometry; Oxidative Stress; Peptide Mapping; Protein Carbonylation; Protein Processing, Post-Translational; Reactive Nitrogen Species; Reactive Oxygen Species; Succinimides | 2008 |
BJSM reviews: A-Z of supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance Part 2.
Topics: Amino Acids; Androstenedione; Arginine; Asparagine; Aspartic Acid; Athletic Performance; Dietary Supplements; Humans; Male; Testosterone | 2009 |
Mass spectrometric analysis of asparagine deamidation and aspartate isomerization in polypeptides.
Topics: Amides; Animals; Asparagine; Aspartic Acid; Electrophoresis, Gel, Two-Dimensional; Humans; Isomerism; Mass Spectrometry; Mice; Proteomics | 2010 |
Polymorphism of ERCC2 Asp312Asn with lung cancer risk: evidence from 20,101 subjects.
Topics: Asparagine; Aspartic Acid; Case-Control Studies; Humans; Lung Neoplasms; Polymorphism, Genetic; Xeroderma Pigmentosum Group D Protein | 2014 |
Recent research progress on microbial L-asparaginases.
Topics: Acrylamide; Asparaginase; Asparagine; Aspartic Acid; Bacteria; Fungi; Humans; Hydrolysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2015 |
Self-generated covalent cross-links in the cell-surface adhesins of Gram-positive bacteria.
Topics: Adhesins, Bacterial; Asparagine; Aspartic Acid; Bacterial Adhesion; Fimbriae Proteins; Glutamine; Gram-Positive Bacteria; Lysine; Models, Molecular; Protein Conformation; Protein Folding; Protein Interaction Domains and Motifs; Protein Stability; Threonine | 2015 |
Fuelling cancer cells.
Topics: Asparagine; Aspartic Acid; Disease Progression; Female; Humans; Lactic Acid; Male; Neoplasms; Oxygen Consumption; Proteins; Reference Values; Tumor Cells, Cultured; Tumor Microenvironment | 2019 |
Microbial L-asparaginase: purification, characterization and applications.
Topics: Ammonia; Asparaginase; Asparagine; Aspartic Acid; Bacteria; Fungi; Hodgkin Disease; Humans; Phylogeny; Plants; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Human aspartyl (asparaginyl) hydroxylase. A multifaceted enzyme with broad intra- and extra-cellular activity.
Topics: Asparagine; Aspartic Acid; Humans; Hydroxylation; Mixed Function Oxygenases | 2021 |
8 trial(s) available for aspartic acid and asparagine
| Article | Year |
|---|---|
Aspartame-sweetened beverage: effect on plasma amino acid concentrations in normal adults and adults heterozygous for phenylketonuria.
Topics: Adult; Amino Acids; Asparagine; Aspartame; Aspartic Acid; Beverages; Biological Transport; Dipeptides; Female; Glutamates; Glutamic Acid; Glutamine; Heterozygote; Humans; Kinetics; Male; Phenylalanine; Phenylketonurias; Tyrosine | 1987 |
Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment-resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity.
Topics: Adult; Aged; Alanine; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arginine; Asparagine; Aspartic Acid; Depressive Disorder, Major; Drug Resistance; Drug Therapy, Combination; Excitatory Amino Acids; Female; Fluoxetine; Glycine; Histidine; Humans; Male; Middle Aged; Personality Inventory; Pindolol; Prognosis; Selective Serotonin Reuptake Inhibitors; Serine; Taurine; Threonine; Trazodone; Treatment Outcome | 1998 |
Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1).
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Amino Acid Substitution; Analysis of Variance; Asparagine; Aspartic Acid; Female; Genotype; Humans; Hydrocortisone; Infusions, Intravenous; Male; Naloxone; Narcotic Antagonists; Polymorphism, Genetic; Receptors, Opioid, mu | 2003 |
The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial.
Topics: Administration, Cutaneous; Administration, Intranasal; Adult; Asparagine; Aspartic Acid; Female; Follow-Up Studies; Genetic Variation; Humans; Male; Middle Aged; Nicotine; Predictive Value of Tests; Receptors, Opioid, mu; Smoking; Time Factors | 2004 |
An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study.
Topics: Acamprosate; Adult; Alcoholism; Alleles; Amino Acid Substitution; Asparagine; Aspartic Acid; Cognitive Behavioral Therapy; Combined Modality Therapy; Drug Therapy, Combination; Female; Genetic Carrier Screening; Genetic Markers; Genotype; Homozygote; Humans; Liver Function Tests; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pharmacogenetics; Polymorphism, Genetic; Prognosis; Receptors, Opioid, mu; Taurine; Temperance; Treatment Outcome | 2008 |
Protein modification by deamidation indicates variations in joint extracellular matrix turnover.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Asparagine; Aspartic Acid; Cartilage; Cartilage Oligomeric Matrix Protein; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix Proteins; Female; Glycoproteins; Humans; Male; Mass Spectrometry; Matrilin Proteins; Middle Aged; Osteoarthritis, Hip; Osteoarthritis, Knee; Protein Processing, Post-Translational | 2012 |
Effect of the Tottori familial disease mutation (D7N) on the monomers and dimers of Aβ40 and Aβ42.
Topics: Alzheimer Disease; Amination; Amyloid beta-Peptides; Asparagine; Aspartic Acid; Humans; Hydrogen-Ion Concentration; Lysine; Molecular Dynamics Simulation; Multiprotein Complexes; Mutation; Peptide Fragments; Protein Multimerization; Protein Structure, Secondary; Static Electricity; Substrate Specificity; Up-Regulation | 2013 |
Naltrexone vs Placebo for the Treatment of Alcohol Dependence: A Randomized Clinical Trial.
Topics: Adult; Alcohol Drinking; Alcoholism; Alleles; Asparagine; Aspartic Acid; Double-Blind Method; Drug Administration Schedule; Female; Genotype; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Odds Ratio; Polymorphism, Single Nucleotide; Recurrence; Treatment Outcome | 2015 |
1152 other study(ies) available for aspartic acid and asparagine
| Article | Year |
|---|---|
Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives.
Topics: Amino Acids; Humans; Mathematics; Peptides; Structure-Activity Relationship; Taste | 1987 |
DL-threo-beta-Fluoroaspartate and DL-threo-beta-fluoroasparagine: selective cytotoxic agents for mammalian cells in culture.
Topics: Amino Acids; Animals; Antineoplastic Agents; Asparagine; Aspartic Acid; Cells, Cultured; Models, Molecular; Neoplasms, Experimental; Rats; Stereoisomerism; Structure-Activity Relationship; X-Ray Diffraction | 1982 |
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis | 2001 |
Zoospore chemotaxis in Australian isolates of Phytophthora species.
Topics: Amino Acids; Asparagine; Aspartic Acid; Chemotaxis; Drug Synergism; Ethanol; Fructose; Fungi; Glutamates; Glutamine; Hydrogen-Ion Concentration; Phytophthora; Spores, Fungal; Sucrose | 1976 |
Structure-activity relationships of amino acids in fish olfaction.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Dose-Response Relationship, Drug; Electric Conductivity; Models, Molecular; Olfactory Bulb; Salmonidae; Smell; Structure-Activity Relationship; Trout | 1976 |
Effects of pH on the olfactory responses to amino acids in rainbow trout, Salmo gairdneri.
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; Electric Conductivity; Hydrogen-Ion Concentration; Methionine; Olfactory Bulb; Salmonidae; Serine; Smell; Trout | 1976 |
DON, CONV and DONV-II. Inhibition of L-'asparagine synthetase in vivo.
Topics: Amino Acids; Animals; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Azo Compounds; Cells, Cultured; Diazooxonorleucine; DNA; Formates; Glutamine; Levulinic Acids; Ligases; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Pancreas | 1976 |
Hemoglobin providence. Functional consequences of two alterations of the 2,3-diphosphoglycerate binding site at position beta 82.
Topics: Adult; Asparagine; Aspartic Acid; Binding Sites; Carbon Monoxide; Diphosphoglyceric Acids; Female; Hemoglobins, Abnormal; Humans; Hydrogen-Ion Concentration; Lysine; Molecular Conformation; Osmolar Concentration; Oxygen; Phytic Acid; Protein Conformation; Sodium Chloride | 1976 |
Hemoglobin Tarrant: alpha126(H9) Asp leads to Asn. A new hemoglobin variant in the alpha1beta1 contact region showing high oxygen affinity and reduced cooperativity.
Topics: Amino Acid Sequence; Amino Acids; Asparagine; Aspartic Acid; Child; Diphosphoglyceric Acids; Electrophoresis, Cellulose Acetate; Fetal Hemoglobin; Hemoglobin, Sickle; Hemoglobins, Abnormal; Humans; Hydrogen-Ion Concentration; Macromolecular Substances; Male; Molecular Weight; Oxygen; Peptide Fragments | 1977 |
Spontaneous deamidation of a protein antibiotic, neocarzinostatin, at weakly acidic pH. Conversion to a homologous inactive preneocarzinostatin due to change of asparagine 83 to aspartic acid 83 accompanied by conformational and biological alterations.
Topics: Amino Acids; Antibiotics, Antineoplastic; Asparagine; Aspartic Acid; Hydrogen-Ion Concentration; Peptide Fragments; Pronase; Protein Conformation; Sarcina; Structure-Activity Relationship; Zinostatin | 1977 |
Postsynthetic deamidation of hemoglobin Providence (beta 82 Lys replaced by Asn, Asp) and its effect on oxygen transport.
Topics: Adolescent; Adult; Asparagine; Aspartic Acid; Child, Preschool; Diphosphoglyceric Acids; Erythrocytes; Female; Glycine; Hemoglobins, Abnormal; Humans; Hydrogen-Ion Concentration; Infant; Leucine; Lysine; Male; Oxygen; Peptide Fragments; Protein Binding | 1977 |
The cellular role of nitrogen in the biosynthesis of alkaloids by submerged culture of Claviceps purpurea (Fr.) Tul.
Topics: Amino Acids; Ammonia; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Claviceps; Ergot Alkaloids; Fermentation; Glutamate Dehydrogenase; Glutamate Synthase; Nitrogen; Quaternary Ammonium Compounds; Tryptophan | 1977 |
The biochemical pathway for the breakdown of N4-ethyl-L-asparagine in the bacterium Pseudomonas stutzeri.
Topics: Amino Acids; Asparagine; Aspartic Acid; Cell-Free System; Hydrogen-Ion Concentration; Ketoglutaric Acids; Pseudomonas | 1978 |
A radiometric method for the measurement of L-asparagine synthetase activity: comparison with available methods.
Topics: Animals; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Carbon Radioisotopes; Cell Line; Guinea Pigs; Leukemia, Experimental; Ligases; Methods; Tissue Distribution | 1978 |
[Metabolism of dicarboxylic amino acids and their amides in bacteria of the genus Citrobacter].
Topics: Amides; Amino Acids, Dicarboxylic; Asparagine; Aspartic Acid; Citrobacter; Deamination; Decarboxylation; Enzyme Activation; Glutamates; Glutamine; Hydrogen-Ion Concentration | 1979 |
Alterations in SVT2 cell transfer RNAs in response to cell density and serum type.
Topics: Animals; Asparagine; Aspartic Acid; Cattle; Cell Line; Cell Transformation, Neoplastic; Culture Media; Cyanogen Bromide; Histidine; Mice; Mice, Inbred BALB C; RNA, Transfer; RNA, Viral; Simian virus 40; Tyrosine | 1975 |
Potential inhibitors of L-asparagine biosynthesis. 2. Chemistry and biological activity of beta-hydroxyaspartic acid and its derivatives.
Topics: Animals; Asparagine; Aspartic Acid; Carcinoma, Hepatocellular; Depression, Chemical; Glutamine; Hydroxy Acids; Ligases; Liver Neoplasms; Male; Molecular Conformation; Neoplasms, Experimental; Rats; Stereoisomerism; Structure-Activity Relationship | 1975 |
N-terminal amino acid sequences in the major capsid proteins of foot-and-mouth disease virus types A, O, and C.
Topics: Amino Acid Sequence; Amino Acids; Aphthovirus; Asparagine; Aspartic Acid; Dansyl Compounds; Glycine; Leucyl Aminopeptidase; Serine; Serotyping; Threonine; Viral Proteins | 1975 |
Relation of cell type and cell density in tissue culture to the isoaccepting spectra of the nucleoside Q containing tRNAs: tRNATyr, tRNAHis, tRNAAsn and tRNAAsp.
Topics: Asparagine; Aspartic Acid; Cell Line; Cell Transformation, Neoplastic; Contact Inhibition; Cyanogen Bromide; Guanosine; Histidine; RNA, Transfer; Simian virus 40; Tyrosine | 1978 |
Improved growth media for Vibrio succinogenes.
Topics: Asparagine; Aspartic Acid; Buffers; Culture Media; Evaluation Studies as Topic; Formates; Fumarates; Hydrogen-Ion Concentration; Malates; Nitrates; Phosphates; Quaternary Ammonium Compounds; Succinates; Thioglycolates; Vibrio | 1975 |
Haemoglobin G Norfolk alpha 85 (F6) Asp leads to Asn. Structural characterization by sequenator analysis and functional properties of a new variant with high oxygen affinity.
Topics: Aged; Amino Acid Sequence; Amino Acids; Asparagine; Aspartic Acid; Chromatography, Ion Exchange; England; France; Genetic Variation; Hemoglobins, Abnormal; Humans; Hydrogen-Ion Concentration; Leukemia, Lymphoid; Oxygen; Protein Binding; Trypsin | 1975 |
The relationship between length of incubation, bacterial growth and tuberculin yield of a strain of Mycobacterium tuberculosis.
Topics: Alanine; Asparagine; Aspartic Acid; Bacteriological Techniques; Chromatography, Paper; Culture Media; Glutamates; Hydrogen-Ion Concentration; Leucine; Mycobacterium tuberculosis; Time Factors; Tuberculin; Valine | 1975 |
L-Asparaginase of Saccharomyces cerevisiae: an extracellular Enzyme.
Topics: Ammonia; Asparaginase; Asparagine; Aspartic Acid; Cell-Free System; Cycloheximide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymercuribenzoates; Mutation; Nitrogen; Saccharomyces cerevisiae; Species Specificity; Stereoisomerism | 1975 |
Gel entrapped L-asparaginase: kinetic behavior and antitumor activity.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Drug Stability; Escherichia coli; Gels; Hydrogen-Ion Concentration; Kinetics; Lymphoma; Mice; Neoplasms, Experimental; Particle Size | 1975 |
Enzymes as reagents in peptide synthesis: enzyme-labile protection for carboxyl groups.
Topics: Asparagine; Aspartic Acid; Carboxypeptidases; Chemical Phenomena; Chemistry; Glutamates; Glutamine; Methods; Proteins; Trypsin | 1977 |
Stimulation of L-asparaginase production in Escherichia coli by organic and amino acids.
Topics: Acids; Amino Acids; Anaerobiosis; Asparaginase; Asparagine; Aspartic Acid; Escherichia coli; Lactates; Leucine; Methionine; Stereoisomerism; Valine | 1977 |
A facile enzymatic method for the location of radioactivity associated with the carbons of L-aspartic acid, L-asparagine, and beta-cyano-L-alanine.
Topics: Alanine; Asparaginase; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Carbon Radioisotopes; Escherichia coli; Isotope Labeling; Kinetics | 1978 |
Structure of the carbohydrate chain of free secretory component from human milk.
Topics: Amino Acids; Asparagine; Aspartic Acid; Carbohydrates; Female; Glycopeptides; Humans; Immunoglobulin Fragments; Methylation; Milk, Human; Pregnancy; Pronase; Secretory Component | 1979 |
Hemoglobin Dunn: alpha 6 (A4) aspartic acid replaced by asparagine.
Topics: Adult; Amino Acid Sequence; Asparagine; Aspartic Acid; Black People; Chemical Phenomena; Chemistry; Female; Hemoglobins, Abnormal; Humans; Peptide Fragments | 1979 |
Potential carcinostatics. Synthesis and biological properties of d- and 1-beta,beta-difluoroaspartic acid and beta,beta-difluoroasparagine.
Topics: Animals; Antineoplastic Agents; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Cell Division; Cells, Cultured; In Vitro Techniques; Leukemia, Experimental; Mice; Rats; Stereoisomerism | 1977 |
Isotachophoretic analysis of serum for aspartic acid, asparagine, glutamic acid and glutamine.
Topics: Asparagine; Aspartic Acid; Chromatography, Ion Exchange; Electrophoresis; Glutamates; Glutamine; Humans | 1978 |
Hemoglobin Matsue-Oki (alpha 75 Asp replaced by Asn) in a black American.
Topics: Asparagine; Aspartic Acid; Black People; Child; Chromatography, Ion Exchange; Electrophoresis, Cellulose Acetate; Female; Hemoglobins, Abnormal; Humans; Japan; Peptides; Texas | 1978 |
Hemoglobin Osu-Christiansborg (beta52 (D3) Aspyield Asn) in an Iranian family.
Topics: Amino Acids; Asparagine; Aspartic Acid; Black People; Electrophoresis, Cellulose Acetate; Genetic Variation; Hemoglobins, Abnormal; Humans; Iran; Peptides | 1978 |
[Recovery after complete cerebral ischemia: free amino acid levels in the brain tissue during and after complete cerebral ischemia (author's transl)].
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; Brain Chemistry; Cats; gamma-Aminobutyric Acid; Glutamates; Glutamine; Ischemic Attack, Transient | 1978 |
Consequences of aspartase deficiency in Yersinia pestis.
Topics: Amino Acids; Ammonia-Lyases; Asparagine; Aspartate Ammonia-Lyase; Aspartic Acid; Glutamates; Glutamine; Proline; Yersinia; Yersinia pestis | 1978 |
Clinical isolates of anaerobic gram-negative rods with a formate-fumarate energy metabolism: Bacteroides corrodens, Vibrio succionogenes, and unidentified strains.
Topics: Asparagine; Aspartic Acid; Bacterial Infections; Bacteroides; Eikenella corrodens; Electron Transport; Energy Metabolism; Formates; Fumarates; Gram-Negative Anaerobic Bacteria; Humans; Malates; Nitrates; Vibrio | 1976 |
Perfusion trials with a collagen-immobilized enzyme in an extracorporeal reactor: activity, stability, and biocompatibility.
Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Biocompatible Materials; Blood Cell Count; Collagen; Dogs; Enzymes, Immobilized; Hematocrit; Perfusion; Time Factors | 1977 |
Hemoglobin Matsue-Oki: alpha 75 (EF 4) aspartic acid leads to asparagine.
Topics: Amino Acids; Asparagine; Aspartic Acid; Hemoglobins, Abnormal; Humans | 1977 |
Hemoglobin Alamo (alpha2beta2 19 (b1) Asn replaced by Asp).
Topics: Adult; Asparagine; Aspartic Acid; Female; Hemoglobins, Abnormal; Humans; Texas | 1977 |
Differentiation of Claviceps purpurea in axenic culture.
Topics: Amino Acids; Asparagine; Aspartic Acid; Claviceps; Ergot Alkaloids; Glutamates; Glutamine; Lipids; Morphogenesis; Spores, Fungal; Triglycerides | 1976 |
Metabolism of absorbed aspartate, asparagine, and arginine by rat small intestine in vivo.
Topics: Amino Acids; Animals; Arginase; Arginine; Asparagine; Aspartic Acid; Biological Transport, Active; Carboxylic Acids; Glucose; Intestinal Absorption; Jejunum; Kinetics; Rats; Urea | 1976 |
Structure and function of insulin: preparation and biological activity of guinea pig des B-Asp30,des-A-Asn21-insulin.
Topics: Adipose Tissue; Amino Acids; Animals; Asparagine; Aspartic Acid; Binding, Competitive; Biological Assay; Cattle; Guinea Pigs; Insulin; Kinetics; Male; Rats; Receptor, Insulin | 1976 |
Amino acid metabolism in Friedreich's ataxia.
Topics: Alanine; Amino Acids; Aminobutyrates; Asparagine; Aspartic Acid; Friedreich Ataxia; Glycine; Histidine; Humans; Isoleucine; Ornithine; Phenylalanine; Phosphatidylethanolamines; Sarcosine; Serine; Taurine; Tyrosine; Valine | 1976 |
Hemoglobin Providence. A human hemoglobin variant occurring in two forms in vivo.
Topics: Adult; Amino Acids; Asparagine; Aspartic Acid; Blood Protein Electrophoresis; Female; Genetic Variation; Hemoglobins, Abnormal; Humans; Male; Pedigree; Peptide Fragments | 1976 |
[Studies on the metabolism of l-asparaginic acid (author's transl)].
Topics: Adult; Asparagine; Aspartic Acid; Female; Humans; Infusions, Parenteral; Kinetics; Middle Aged | 1976 |
Amino acid metabolism of platelets in leukemia.
Topics: Amino Acids; Asparagine; Aspartic Acid; Blood Platelets; Glucose; Glutamates; Glutamine; Humans; Leukemia, Myeloid, Acute; Remission, Spontaneous | 1976 |
A method of distinguishing between aspartic acid and asparagine and between glutamic acid and glutamine during sequence analysis by the dansyl-Edman procedure.
Topics: Amino Acid Sequence; Amino Acids; Animals; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Bees; Chymotrypsin; Dansyl Compounds; Glutamates; Glutamine; Methods; Pepsin A; Thermolysin; Trypsin; Venoms | 1975 |
Effect of Acinetobacter glutaminase-asparaginase treatment on free amino acids in mouse tissues.
Topics: Acetyltransferases; Acinetobacter; Amino Acids; Ammonia; Animals; Asparaginase; Asparagine; Aspartic Acid; Body Weight; Brain; Escherichia coli; Female; Glutamates; Glutaminase; Glutamine; Kidney; Mice; Organ Size; Serine; Spleen; Threonine | 1975 |
Structure of the modified nucleoside Q isolated from Escherichia coli transfer ribonucleic acid. 7-(4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine.
Topics: Anticodon; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Escherichia coli; Guanosine; Histidine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Protons; RNA, Bacterial; RNA, Transfer; Spectrophotometry, Ultraviolet; Tyrosine | 1975 |
Asparagine metabolism in the bovine lens: a comparison with the metabolism of aspartic acid.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Biological Transport; Cattle; Eye Proteins; Glutamates; Glutamine; Glutathione; Lactates; Lens, Crystalline; Proline | 1975 |
Haemoglobin G Norfolk: alpha 85 (F6) Asp leads to Asn.
Topics: Amino Acids; Asparagine; Aspartic Acid; Cyanogen Bromide; Electrophoresis, Paper; Endopeptidases; England; Female; Hemoglobins, Abnormal; Humans; Male; Peptide Fragments | 1975 |
An asparagine requirement in young rats fed the dietary combinations of aspartic acid, glutamine, and glutamic acid.
Topics: Animal Nutritional Physiological Phenomena; Animals; Asparagine; Aspartic Acid; Body Weight; Deficiency Diseases; DNA; Drug Synergism; Glutamates; Glutamine; Liver; Male; Muscles; Myocardium; Nutritional Requirements; Organ Size; Protein Biosynthesis; Rats | 1975 |
Conditionally lethal mutations in chinese hamster cells. Characterization of a cell line with a possible defect in the Krebs cycle.
Topics: Acetates; Antimycin A; Asparagine; Aspartic Acid; Butyrates; Carbon Dioxide; Cell Line; Citric Acid Cycle; Cyanides; Glutamates; Ketoglutaric Acids; Microscopy, Electron; Mitochondria; Mutation; Oxygen Consumption; Palmitic Acids; Pyruvates; Succinates | 1975 |
Haemoglobin Arya: alpha 2-47 (CD5), aspartic acid yields asparagine.
Topics: Amino Acids; Asparagine; Aspartic Acid; Chymotrypsin; Female; Hemoglobins, Abnormal; Humans; Iran; Middle Aged; Peptide Fragments; Temperature | 1975 |
Synthesis by conventional methods of human growth hormone peptide fragments. I.
Topics: Alanine; Asparagine; Aspartic Acid; Glutamine; Growth Hormone; Histidine; Humans; Leucine; Lysine; Optical Rotation; Peptides; Phenylalanine; Serine; Threonine; Tyrosine | 1975 |
[Regulation of nitrogenase from lupin bacteroids].
Topics: Acetylene; Alanine; Amides; Amino Acids; Asparagine; Aspartic Acid; Glutamates; Glutamine; Glyoxylates; Hydroxybutyrates; Keto Acids; Ketoglutaric Acids; Nitrogenase; Oxaloacetates; Rhizobium | 1975 |
Carbohydrate and amino acid metabolism in rat cerebral cortex in moderate and extreme hypercapnia.
Topics: Acute Disease; Alanine; Amino Acids; Ammonia; Anesthesia, General; Animals; Asparagine; Aspartic Acid; Carbohydrate Metabolism; Cerebral Cortex; Citric Acid Cycle; Fructosephosphates; gamma-Aminobutyric Acid; Glucosephosphates; Glutamates; Glutamine; Glycogen; Glycolysis; Hypercapnia; Lactates; Male; Pyruvates; Rats | 1975 |
Haemoglobin Titusville: alpha94 Asp replaced by Asn. A new haemoglobin with a lowered affinity for oxygen.
Topics: Asparagine; Aspartic Acid; Binding Sites; Child, Preschool; Female; Hemoglobins; Hemoglobins, Abnormal; Humans; Kansas; Kinetics; Macromolecular Substances; Oxygen; Peptide Fragments; Phytic Acid; Protein Binding; Texas | 1975 |
The hydrolysis of some N-acylaspartic and N-acylglutamic monoamides in dilute mineral acid.
Topics: Amides; Asparagine; Aspartic Acid; Benzoates; Chemical Phenomena; Chemistry; Glutamates; Hydrolysis; Kinetics | 1975 |
Characterization of functional groups of acidic thermal polymers of alpha-amino acids.
Topics: Amides; Amino Acid Sequence; Amino Acids; Ammonia; Asparagine; Aspartic Acid; Hot Temperature; Peptides; Temperature | 1975 |
Studies on trypsin inhibitors. Part III. Synthesis of the protected decapeptide (sequence 15-24) of porcine pancreatic secretory trypsin inhibitor II (Kazal).
Topics: Animals; Asparagine; Aspartic Acid; Cysteine; Glycine; Isoleucine; Peptides; Proline; Swine; Threonine; Trypsin Inhibitor, Kazal Pancreatic; Trypsin Inhibitors; Tyrosine; Valine | 1976 |
Surface activity of hemoglobin S and other human hemoglobin variants.
Topics: Asparagine; Aspartic Acid; Glutamates; Hemoglobin, Sickle; Hemoglobins; Hemoglobins, Abnormal; Humans; Kinetics; Lysine; New York City; Osmolar Concentration; Oxygen; Pressure; Protein Conformation; Sodium Chloride; Surface Properties; Thermodynamics; Valine | 1976 |
Influence of casein and soy flour proteins on aminoacid content in the liver of experimental animals.
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; Caseins; Cystine; Dietary Proteins; Food, Fortified; Glycine; Liver; Methionine; Norleucine; Ornithine; Plant Proteins, Dietary; Rats; Soybean Proteins; Taurine | 1992 |
Solid-phase minisequencing test reveals Asp187----Asn (G654----A) mutation of gelsolin in all affected individuals with Finnish type of familial amyloidosis.
Topics: Amyloidosis; Asparagine; Aspartic Acid; Base Sequence; Calcium-Binding Proteins; Finland; Gelsolin; Humans; Microfilament Proteins; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Oligodeoxyribonucleotides; Polymerase Chain Reaction | 1992 |
Effect of Asp-235-->Asn substitution on the absorption spectrum and hydrogen peroxide reactivity of cytochrome c peroxidase.
Topics: Asparagine; Aspartic Acid; Buffers; Cytochrome-c Peroxidase; Heme; Hydrogen Peroxide; Hydrogen-Ion Concentration; Kinetics; Nitrates; Phosphates; Spectrum Analysis | 1992 |
Two alloalbumins with identical electrophoretic mobility are produced by differently charged amino acid substitutions.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Genetic Variation; Glutamates; Glutamic Acid; Humans; Isoelectric Focusing; Lysine; Molecular Sequence Data; Mutation; Serum Albumin | 1992 |
A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents.
Topics: Adrenergic alpha-Agonists; Animals; Asparagine; Aspartic Acid; Brimonidine Tartrate; Calcium Channels; Cell Line; Clonidine; GTP-Binding Proteins; Membrane Potentials; Mutagenesis, Site-Directed; Potassium Channels; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Neurotransmitter; Receptors, Somatostatin; Recombinant Proteins; Somatostatin; Transfection | 1992 |
Mechanistic consequences of mutation of the active site nucleophile Glu 358 in Agrobacterium beta-glucosidase.
Topics: Asparagine; Aspartic Acid; beta-Glucosidase; Binding Sites; Deuterium; Drug Stability; Glucosides; Glutamates; Glutamic Acid; Glutamine; Glycosylation; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Protein Conformation; Rhizobium; Structure-Activity Relationship | 1992 |
The use of modified divinylbenzene-polystyrene resins in the separation of fermentation products. A case study utilizing amino acids and a dipeptide.
Topics: Adsorption; Amino Acids; Asparagine; Aspartame; Aspartic Acid; Chromatography, High Pressure Liquid; Dipeptides; Fermentation; Hydrogen-Ion Concentration; Kinetics; Osmolar Concentration; Phenylalanine; Polystyrenes; Resins, Plant; Temperature; Thermodynamics; Vinyl Compounds | 1992 |
Protein changes associated with reprotonation of the Schiff base in the photocycle of Asp96-->Asn bacteriorhodopsin. The MN intermediate with unprotonated Schiff base but N-like protein structure.
Topics: Asparagine; Aspartic Acid; Bacteriorhodopsins; Fourier Analysis; Halobacterium salinarum; Kinetics; Light; Protein Conformation; Recombinant Proteins; Schiff Bases; Spectrophotometry; Spectrophotometry, Infrared | 1992 |
Seizure related elevations of extracellular amino acids in human focal epilepsy.
Topics: Amino Acids; Asparagine; Aspartic Acid; Cerebral Cortex; Dialysis; Electroencephalography; Epilepsies, Partial; Extracellular Space; Glutamates; Glycine; Humans; Seizures; Serine | 1992 |
Asn177 in Escherichia coli thymidylate synthase is a major determinant of pyrimidine specificity.
Topics: Asparagine; Aspartic Acid; Base Sequence; Binding Sites; Escherichia coli; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Pyrimidines; Substrate Specificity; Thymidylate Synthase | 1992 |
Degradation of aspartic acid and asparagine residues in human growth hormone-releasing factor.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Growth Hormone-Releasing Hormone; Humans; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Stereoisomerism; Temperature | 1992 |
Antibody-catalyzed rearrangement of the peptide bond.
Topics: Antibodies, Catalytic; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Dipeptides; Glycine; Hydrogen-Ion Concentration; Kinetics; Peptides; Stereoisomerism; Succinimides | 1992 |
Mutational analysis of pea lectin. Substitution of Asn125 for Asp in the monosaccharide-binding site eliminates mannose/glucose-binding activity.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Binding Sites; Calcium; DNA Mutational Analysis; Escherichia coli; Fabaceae; Glucose; Lectins; Manganese; Mannose; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phytohemagglutinins; Plant Lectins; Plants, Medicinal; Sequence Alignment; Structure-Activity Relationship | 1992 |
Anion binding to the Schiff base of the bacteriorhodopsin mutants Asp-85----Asn/Asp-212----Asn and Arg-82----Gln/Asp-85----Asn/Asp-212----Asn.
Topics: Amino Acid Sequence; Anions; Asparagine; Aspartic Acid; Bacteriorhodopsins; Binding Sites; Glutamine; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Osmolar Concentration; Protein Conformation; Recombinant Proteins; Schiff Bases; Sodium Chloride; Spectrophotometry | 1992 |
Binding of protein S to C4b-binding protein. Mutagenesis of protein S.
Topics: 1-Carboxyglutamic Acid; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Base Sequence; Blood Proteins; Carrier Proteins; Cattle; Cells, Cultured; Complement Inactivator Proteins; Glycoproteins; Humans; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein S; Recombinant Proteins; Solutions; Thrombin; Transfection | 1992 |
Deamidation of human erythrocyte protein 4.1: possible role in aging.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Cyanogen Bromide; Cytoskeletal Proteins; Electrophoresis, Polyacrylamide Gel; Erythrocyte Aging; Humans; Mass Spectrometry; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Neuropeptides; Peptide Fragments; Protein Processing, Post-Translational; Serine Endopeptidases | 1992 |
Mutation of asparagine 229 to aspartate in thymidylate synthase converts the enzyme to a deoxycytidylate methylase.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Catalysis; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Kinetics; Lacticaseibacillus casei; Molecular Sequence Data; Mutation; Sequence Alignment; Spectrophotometry, Ultraviolet; Substrate Specificity; Thymidylate Synthase | 1992 |
Substitution of ASP193 to ASN at the active site of ribulose-1,5-bisphosphate carboxylase results in conformational changes.
Topics: Asparagine; Aspartic Acid; Binding Sites; Crystallization; Macromolecular Substances; Magnesium; Molecular Structure; Mutagenesis, Insertional; Protein Conformation; Rhodospirillum rubrum; Ribulose-Bisphosphate Carboxylase; Structure-Activity Relationship; X-Ray Diffraction | 1992 |
Modulation by certain conserved aspartate residues of the allosteric interaction of gallamine at the m1 muscarinic receptor.
Topics: Animals; Asparagine; Aspartic Acid; Cells, Cultured; Cricetinae; Cricetulus; Drug Residues; Female; Gallamine Triethiodide; N-Methylscopolamine; Ovary; Receptors, Muscarinic; Scopolamine Derivatives | 1992 |
Properties of Asp212----Asn bacteriorhodopsin suggest that Asp212 and Asp85 both participate in a counterion and proton acceptor complex near the Schiff base.
Topics: Asparagine; Aspartic Acid; Bacteriorhodopsins; Genes, Bacterial; Halobacterium; Hydrogen-Ion Concentration; Mutation; Plasmids; Protons; Schiff Bases; Spectrum Analysis; X-Ray Diffraction | 1991 |
Characterization of glutamate uptake systems in astrocyte primary cultures from rat brain.
Topics: Animals; Asparagine; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; Chlorides; Glutamates; Glutamic Acid; Ion Channels; Kinetics; Potassium; Quisqualic Acid; Rats; Sodium | 1991 |
Structural changes that accompany the reduced catalytic efficiency of two semisynthetic ribonuclease analogs.
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Crystallization; Molecular Sequence Data; Protein Conformation; Ribonucleases; Structure-Activity Relationship; Temperature | 1992 |
Measurement of serum L-asparagine in the presence of L-asparaginase requires the presence of an L-asparaginase inhibitor.
Topics: Aminolevulinic Acid; Asparaginase; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Humans | 1991 |
Substitution of aspartic acid-686 by histidine or asparagine in the human androgen receptor leads to a functionally inactive protein with altered hormone-binding characteristics.
Topics: Adult; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Base Sequence; Chloramphenicol O-Acetyltransferase; Codon; Exons; Female; Fibroblasts; HeLa Cells; Histidine; Humans; Kinetics; Male; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Pedigree; Polymerase Chain Reaction; Receptors, Androgen; Recombinant Fusion Proteins; Skin; Transfection | 1991 |
Age-dependent deamidation of the major intrinsic polypeptide from lens membranes.
Topics: Aging; Amino Acid Sequence; Animals; Aquaporins; Asparagine; Aspartic Acid; Cattle; Chromatography, High Pressure Liquid; Deamination; Eye Proteins; Lens, Crystalline; Membrane Glycoproteins; Molecular Sequence Data; Protein Processing, Post-Translational; Radioimmunoassay | 1991 |
Spontaneous degradation and enzymatic repair of aspartyl and asparaginyl residues in aging red cell proteins analyzed by computer simulation.
Topics: Asparagine; Aspartic Acid; Blood Proteins; Computer Simulation; Dose-Response Relationship, Drug; Erythrocyte Aging; Hemoglobins; Humans; Methyltransferases; Models, Biological | 1991 |
beta-Hydroxyaspartic acid and beta-hydroxyasparagine residues in recombinant human protein S are not required for anticoagulant cofactor activity or for binding to C4b-binding protein.
Topics: Anticoagulants; Asparagine; Aspartic Acid; Calcium; Carrier Proteins; Cell Line; Complement Inactivator Proteins; DNA Mutational Analysis; Factor Va; Glycoproteins; Humans; In Vitro Techniques; Protein Binding; Protein S; Recombinant Proteins; Structure-Activity Relationship; Thrombin | 1991 |
Mutation of a negatively charged amino acid in thioredoxin modifies its reactivity with chloroplastic enzymes.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Chloroplast Thioredoxins; Chloroplasts; Circular Dichroism; Escherichia coli; Fructose-Bisphosphatase; Kinetics; Malate Dehydrogenase; Molecular Sequence Data; Mutagenesis, Site-Directed; Plant Proteins; Plants; Sequence Homology, Nucleic Acid; Spectrometry, Fluorescence; Substrate Specificity; Thioredoxins | 1991 |
Effects of Asp-96----Asn, Asp-85----Asn, and Arg-82----Gln single-site substitutions on the photocycle of bacteriorhodopsin.
Topics: Arginine; Asparagine; Aspartic Acid; Bacteriorhodopsins; Biological Transport, Active; Glutamine; Halobacterium; In Vitro Techniques; Kinetics; Light; Photosynthesis; Recombinant Proteins; Retinaldehyde; Schiff Bases; Spectrum Analysis; Structure-Activity Relationship | 1991 |
Histidine pKa shifts accompanying the inactivating Asp121----Asn substitution in a semisynthetic bovine pancreatic ribonuclease.
Topics: Animals; Asparagine; Aspartic Acid; Cattle; Histidine; In Vitro Techniques; Magnetic Resonance Spectroscopy; Ribonucleases; Structure-Activity Relationship | 1991 |
Structural and functional effects of mutations altering the subunit interface of mitochondrial malate dehydrogenase.
Topics: Acetates; Acetic Acid; Amino Acid Sequence; Asparagine; Aspartic Acid; Blotting, Western; Chromatography, Gel; Codon; Histidine; Hydrogen-Ion Concentration; Kinetics; Leucine; Macromolecular Substances; Malate Dehydrogenase; Mitochondria; Molecular Sequence Data; Mutagenesis; Saccharomyces cerevisiae; Structure-Activity Relationship | 1991 |
Site-directed mutagenesis of dicarboxylic acids near the active site of Bacillus cereus 5/B/6 beta-lactamase II.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Bacillus cereus; Base Sequence; Binding Sites; Blotting, Western; Cephalosporinase; Cloning, Molecular; Escherichia coli; Genetic Vectors; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenotype; Recombinant Proteins; Restriction Mapping | 1991 |
Analysis of the interaction between charged side chains and the alpha-helix dipole using designed thermostable mutants of phage T4 lysozyme.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Enzyme Stability; Hot Temperature; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Muramidase; Mutagenesis, Site-Directed; Protein Conformation; T-Phages; Thermodynamics; X-Ray Diffraction | 1991 |
Anti-tumoral activity of L and D isomers of aspartic acid beta-hydroxamate on L5178Y leukemia.
Topics: Animals; Asparagine; Aspartic Acid; Drug Screening Assays, Antitumor; Isomerism; Leukemia L5178; Mice; Mice, Inbred DBA | 1991 |
Transport of L-asparagine in Tetrahymena pyriformis ecto-L-asparaginase is not related to L-asparagine-protein transport system.
Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Biological Transport, Active; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Ouabain; Potassium; Tetrahymena pyriformis; Vanadates | 1991 |
Aspartate and asparagine as electron acceptors for Wolinella recta.
Topics: Asparaginase; Asparagine; Aspartate Ammonia-Lyase; Aspartic Acid; Electron Transport; Formates; Humans; Periodontitis; Wolinella | 1991 |
Determinants of visual pigment absorbance: identification of the retinylidene Schiff's base counterion in bovine rhodopsin.
Topics: Animals; Asparagine; Aspartic Acid; Cattle; Glutamates; Glutamic Acid; Glutamine; Kinetics; Membranes; Models, Molecular; Mutagenesis, Site-Directed; Plasmids; Protein Conformation; Recombinant Proteins; Retinaldehyde; Rhodopsin; Schiff Bases; Spectrophotometry | 1990 |
The glucose transport activity of GLUT1 is markedly decreased by substitution of a single amino acid with a different charge at residue 415.
Topics: Animals; Asparagine; Aspartic Acid; Binding Sites; Cell Membrane; Cells, Cultured; Cricetinae; Cricetulus; Cytochalasin B; Deoxyglucose; DNA; Glucose; Kinetics; Monosaccharide Transport Proteins; Mutation | 1991 |
Amino acids with central pressor effect in conscious rats.
Topics: Amino Acids; Animals; Arginine; Asparagine; Aspartic Acid; Blood Pressure; Cysteine; Dose-Response Relationship, Drug; Heart Rate; Injections, Intravenous; Male; Pressoreceptors; Proline; Rats; Rats, Inbred Strains | 1990 |
Molecular basis for the properties of the thyroxine-binding globulin-slow variant in American blacks.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Black People; DNA; Electrophoresis, Polyacrylamide Gel; Genetic Variation; Humans; Male; Molecular Sequence Data; Mutation; Phenotype; Thyroxine-Binding Proteins; United States | 1990 |
Role of the conserved amino acids of the 'SDN' loop (Ser130, Asp131 and Asn132) in a class A beta-lactamase studied by site-directed mutagenesis.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; beta-Lactamases; Binding Sites; Chemical Phenomena; Chemistry, Physical; Enzyme Stability; Hot Temperature; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Penicillanic Acid; Serine; Streptomyces; Structure-Activity Relationship; Thermodynamics | 1990 |
Comparative proton NMR analysis of wild-type cytochrome c peroxidase from yeast, the recombinant enzyme from Escherichia coli, and an Asp-235----Asn-235 mutant.
Topics: Asparagine; Aspartic Acid; Cytochrome-c Peroxidase; Escherichia coli; Fungal Proteins; Heme; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Fusion Proteins; Saccharomyces cerevisiae | 1990 |
Escherichia coli mutant trpA34 has an Asp----Asn change at active site residue 60 of the tryptophan synthetase alpha chain.
Topics: Asparagine; Aspartic Acid; Base Sequence; Binding Sites; Codon; DNA, Bacterial; Escherichia coli; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Plasmids; Tryptophan Synthase | 1990 |
Crystal structure of the aspartic acid-199----asparagine mutant of chloramphenicol acetyltransferase to 2.35-A resolution: structural consequences of disruption of a buried salt bridge.
Topics: Asparagine; Aspartic Acid; Binding Sites; Chloramphenicol O-Acetyltransferase; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; X-Ray Diffraction | 1990 |
The sequences of two peptides from cataract lenses suggest they arise by deamidation.
Topics: Aged; Aged, 80 and over; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Cataract; Cattle; Crystallins; Deamination; Humans; Lens, Crystalline; Middle Aged; Molecular Sequence Data; Peptide Fragments; Peptides; Rabbits; Radioimmunoassay; Sequence Homology, Nucleic Acid; Trypsin | 1990 |
[Cri-du-chat disease: plasma and urinary amino acids].
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Asparagine; Aspartic Acid; Child; Child, Preschool; Chromosome Aberrations; Chromosome Deletion; Chromosome Disorders; Chromosome Mapping; Chromosomes, Human, Pair 5; Cri-du-Chat Syndrome; Female; Histidine; Humans; Intellectual Disability; Male; Models, Biological; Purine-Pyrimidine Metabolism, Inborn Errors | 1990 |
Hb F-Forest Park, a new A gamma variant with two amino acid substitutions, 75(E19)Ile----Thr and 73(E17)Asp----Asn, which can be identified in adults by gene-mapping analysis.
Topics: Asparagine; Aspartic Acid; Base Sequence; DNA; DNA Restriction Enzymes; Female; Fetal Blood; Fetal Hemoglobin; Genes; Genetic Variation; Hemoglobins, Abnormal; Humans; Infant, Newborn; Isoleucine; Male; Pedigree; Pregnancy; Threonine | 1985 |
Racemization of individual aspartate residues in human myelin basic protein.
Topics: Aged; Amino Acid Isomerases; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Humans; Male; Myelin Basic Protein; Pepsin A; Peptide Fragments; Protein Conformation; Trypsin | 1988 |
Mutagenesis of aspartic acid-116 enhances the ribonucleolytic activity and angiogenic potency of angiogenin.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Chick Embryo; Mutation; Neoplasm Proteins; Neovascularization, Pathologic; Ribonuclease, Pancreatic; RNA | 1988 |
Immunological properties of synthetic human parathyroid hormone: effect of deamidation at position 76.
Topics: Antibodies; Asparagine; Aspartic Acid; Epitopes; Humans; Immune Sera; Iodine Radioisotopes; Parathyroid Hormone; Peptide Fragments; Radioimmunoassay | 1987 |
The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha-chain of the complement component, C3.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Codon; Complement C3; Electrophoresis, Polyacrylamide Gel; Humans; Molecular Sequence Data; Polymorphism, Genetic; Recombinant Proteins; Ribonuclease, Pancreatic; RNA | 1989 |
Calcium affects the spontaneous degradation of aspartyl/asparaginyl residues in calmodulin.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Brain; Calcium; Calmodulin; Cattle; Chromatography, High Pressure Liquid; Egtazic Acid; Methylation; Molecular Sequence Data; Peptide Fragments; Peptide Hydrolases; Protein Conformation; Protein Methyltransferases; Protein O-Methyltransferase | 1989 |
Replacement of aspartic residues 85, 96, 115, or 212 affects the quantum yield and kinetics of proton release and uptake by bacteriorhodopsin.
Topics: Asparagine; Aspartic Acid; Bacteriorhodopsins; Biological Transport, Active; Glutamates; Hydrogen-Ion Concentration; Kinetics; Light; Mutation; Protons | 1989 |
Role of aspartate-96 in proton translocation by bacteriorhodopsin.
Topics: Asparagine; Aspartic Acid; Bacteriorhodopsins; Fourier Analysis; Halobacterium; Protons; Spectrophotometry, Infrared | 1989 |
A defective proton pump, point-mutated bacteriorhodopsin Asp96----Asn is fully reactivated by azide.
Topics: Anions; Asparagine; Aspartic Acid; Azides; Bacteriorhodopsins; Biological Transport; Hydrogen-Ion Concentration; Mutation; Protons; Temperature; Thermodynamics | 1989 |
Effects of buried ionizable amino acids on the reduction potential of recombinant myoglobin.
Topics: Asparagine; Aspartic Acid; Glutamates; Glutamic Acid; Heme; Humans; Mutation; Myoglobin; Oxidation-Reduction; Protein Conformation; Recombinant Proteins; Thermodynamics; Valine | 1989 |
Effect of impact trauma on neurotransmitter and nonneurotransmitter amino acids in rat spinal cord.
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Glycine; Kinetics; Laminectomy; Male; N-Methylaspartate; Neurotransmitter Agents; Rats; Serine; Spinal Cord; Spinal Cord Injuries; Taurine; Threonine | 1989 |
Effect of repeated ingestion of aspartame-sweetened beverage on plasma amino acid, blood methanol, and blood formate concentrations in normal adults.
Topics: Adult; Amino Acids; Asparagine; Aspartame; Aspartic Acid; Beverages; Dipeptides; Female; Formates; Glutamates; Glutamic Acid; Glutamine; Humans; Male; Methanol; Phenylalanine; Tryptophan; Tyrosine | 1989 |
Functional consequences of glutamate, aspartate, glutamine, and asparagine mutations in the stalk sector of the Ca2+-ATPase of sarcoplasmic reticulum.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Biological Transport; Calcium; Calcium-Transporting ATPases; Cell Line; Cloning, Molecular; Glutamates; Glutamic Acid; Glutamine; Immunoblotting; Microsomes; Molecular Sequence Data; Muscles; Mutation; Phosphorylation; Rabbits; Recombinant Fusion Proteins; Sarcoplasmic Reticulum; Transfection | 1989 |
Bacteriorhodopsin mutants of Halobacterium sp. GRB. II. Characterization of mutants.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Bacteriorhodopsins; Base Sequence; Cloning, Molecular; Cysteine; Genes, Bacterial; Glutamates; Glutamic Acid; Glycine; Halobacterium; Molecular Sequence Data; Mutation; Protein Conformation; Tryptophan; Tyrosine | 1989 |
Substitution of membrane-embedded aspartic acids in bacteriorhodopsin causes specific changes in different steps of the photochemical cycle.
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspartic Acid; Bacteriorhodopsins; Cell Membrane; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Lipid Bilayers; Molecular Sequence Data; Mutation; Photochemistry | 1989 |
The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha chain of the complement component, C3.
Topics: Asparagine; Aspartic Acid; Base Sequence; Complement C3; Humans; Molecular Sequence Data | 1989 |
Substitution of asparagine324 with aspartic acid in the Fc portion of mouse antibodies reduces their capacity for C1q binding.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Base Sequence; Complement C1q; Immunoglobulin Fc Fragments; Mice; Molecular Sequence Data; Mutation; Structure-Activity Relationship | 1989 |
Segmented anisotropic refinement of bovine ribonuclease A by the application of the rigid-body TLS model.
Topics: Animals; Arginine; Asparagine; Aspartic Acid; Cattle; Chemical Phenomena; Chemistry, Physical; Glutamates; Glutamine; Histidine; Mathematics; Models, Molecular; Phenylalanine; Ribonuclease, Pancreatic; Sulfates; Tyrosine; X-Ray Diffraction | 1989 |
Replacement of aspartic acid-96 by asparagine in bacteriorhodopsin slows both the decay of the M intermediate and the associated proton movement.
Topics: Asparagine; Aspartic Acid; Bacteriorhodopsins; Escherichia coli; Genes; Genes, Bacterial; Genes, Synthetic; Hydrogen-Ion Concentration; Kinetics; Light; Photolysis | 1989 |
Succinimide formation from aspartyl and asparaginyl peptides as a model for the spontaneous degradation of proteins.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Esters; In Vitro Techniques; Kinetics; Oligopeptides; Proteins; Structure-Activity Relationship; Succinimides | 1989 |
Formation of isoaspartate at two distinct sites during in vitro aging of human growth hormone.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Binding Sites; Cattle; Growth Hormone; Humans; Isomerism; Methylation; Molecular Sequence Data; Peptide Fragments; Recombinant Proteins; Structure-Activity Relationship; Time Factors; Trypsin | 1989 |
The effect of gentamicin on the cockroach nerve cord.
Topics: Action Potentials; Amino Acids; Animals; Asparagine; Aspartic Acid; Cockroaches; Electrophysiology; Gentamicins; In Vitro Techniques; Male; Motor Endplate; Neurons; Synapses | 1989 |
Dihydrofolate reductase: control of the mode of substrate binding by aspartate 26.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Kinetics; Magnetic Resonance Spectroscopy; Protein Conformation; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1989 |
Occurrence of beta-hydroxylated asparagine residues in non-vitamin K-dependent proteins containing epidermal growth factor-like domains.
Topics: Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Complement Activating Enzymes; Complement C1; Complement C1r; Complement C1s; Epidermal Growth Factor; Gas Chromatography-Mass Spectrometry; Humans; Mucoproteins; Protein Processing, Post-Translational; Sequence Homology, Nucleic Acid; Uromodulin | 1987 |
beta-Hydroxyaspartic acid or beta-hydroxyasparagine in bovine low density lipoprotein receptor and in bovine thrombomodulin.
Topics: Adrenal Glands; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Cattle; Epidermal Growth Factor; Molecular Sequence Data; Receptors, Cell Surface; Receptors, LDL; Receptors, Thrombin; Sequence Homology, Nucleic Acid | 1988 |
Site-directed mutagenesis of human beta-adrenergic receptors: substitution of aspartic acid-130 by asparagine produces a receptor with high-affinity agonist binding that is uncoupled from adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Asparagine; Aspartic Acid; Base Sequence; Binding, Competitive; Catecholamines; Cell Line; Gene Expression Regulation; Guanine Nucleotides; Humans; Molecular Sequence Data; Mutation; Receptors, Adrenergic, beta; Sequence Homology, Nucleic Acid | 1988 |
The same extra FokI cleavage site exists in glucose-6-phosphate dehydrogenase variants A(+) and A(-).
Topics: Asparagine; Aspartic Acid; Deoxyribonucleases, Type II Site-Specific; DNA Restriction Enzymes; Genes; Genetic Variation; Glucosephosphate Dehydrogenase; Humans; Mutation; Nucleic Acid Hybridization | 1988 |
Separation of amino acid and amide nitrogen from plant extracts for 15N analysis.
Topics: Amides; Amino Acids; Ammonia; Asparagine; Aspartic Acid; Chromatography, Ion Exchange; Fabaceae; Glutamates; Glutamic Acid; Glutamine; Nitrogen; Nitrogen Isotopes; Plants; Plants, Medicinal | 1986 |
Topographical distribution of neurochemical changes in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids, Dicarboxylic; Asparagine; Aspartic Acid; Cerebellar Cortex; Cerebral Cortex; Choline O-Acetyltransferase; Glutamates; Glutaminase; Glutamine; Humans; Middle Aged; Somatostatin | 1988 |
Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.
Topics: Animals; Asparagine; Aspartic Acid; Cell Membrane; Epinephrine; Glutamates; Glutamic Acid; Isoproterenol; Kinetics; L Cells; Mice; Mutation; Receptors, Adrenergic, beta; Structure-Activity Relationship | 1988 |
Ca2+-dependent activation of the malate-aspartate shuttle by norepinephrine and vasopressin in perfused rat liver.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Calcimycin; Calcium; Ethanol; Glucose; Glutamates; Glutamic Acid; Ketoglutaric Acids; Liver; Malates; Male; Norepinephrine; Perfusion; Rats; Rats, Inbred Strains; Sorbitol; Vasopressins | 1988 |
Influence of total nitrogen, asparagine, and glutamine on MCA tumor growth in the Fischer 344 rat.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Body Weight; Glutamates; Glutamic Acid; Glutamine; Male; Nitrogen; Organ Size; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental | 1988 |
Substitutions in the active site of chloramphenicol acetyltransferase: role of a conserved aspartate.
Topics: Alanine; Arginine; Asparagine; Aspartic Acid; Binding Sites; Chloramphenicol; Chloramphenicol O-Acetyltransferase; Cysteine; Drug Stability; Escherichia coli; Histidine; Hot Temperature; Hydrogen Bonding; Kinetics; Mutation; Structure-Activity Relationship; Sulfhydryl Reagents | 1988 |
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis.
Topics: Animals; Asparagine; Aspartic Acid; Binding Sites; Cattle; Computer Simulation; Crystallography; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Protein Conformation; Rats; Serine; Structure-Activity Relationship; Trypsin | 1987 |
Yeast mutants temperature-sensitive for growth after random mutagenesis of the chromosomal RAS2 gene and deletion of the RAS1 gene.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Arginine; Asparagine; Aspartic Acid; Base Sequence; Carbon; Chromosome Deletion; Cloning, Molecular; Culture Media; DNA, Fungal; Fungal Proteins; Galactose; Genes, ras; Glucose; Glycine; Immunoblotting; Molecular Sequence Data; Mutation; Phenotype; ras Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Temperature; Transformation, Genetic | 1988 |
Function of arginine-234 and aspartic acid-271 in domain closure, cooperativity, and catalysis in Escherichia coli aspartate transcarbamylase.
Topics: Arginine; Asparagine; Aspartate Carbamoyltransferase; Aspartic Acid; Escherichia coli; Kinetics; Models, Molecular; Mutation; Plasmids; Protein Conformation; Serine | 1988 |
Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli.
Topics: Asparagine; Aspartic Acid; Binding Sites; Escherichia coli; Kinetics; Mathematics; Methotrexate; Models, Theoretical; Mutation; Protein Binding; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase | 1988 |
The catalytic role of the active site aspartic acid in serine proteases.
Topics: Animals; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Endopeptidases; Hydrogen-Ion Concentration; Kinetics; Rats; Serine Endopeptidases; Structure-Activity Relationship; Substrate Specificity | 1987 |
A mutation that alters the nucleotide specificity of elongation factor Tu, a GTP regulatory protein.
Topics: Asparagine; Aspartic Acid; Cloning, Molecular; Escherichia coli; Genes; Genes, Bacterial; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Mutation; Peptide Elongation Factor Tu; Plasmids; Protein Binding | 1987 |
Chiral beta and random fractional deuteration for the determination of protein sidechain conformation by NMR.
Topics: Asparagine; Aspartic Acid; Bacterial Proteins; Escherichia coli; Magnetic Resonance Spectroscopy; Protein Conformation; Stereoisomerism; Thioredoxins | 1987 |
1H-NMR studies of synthetic peptide analogues of calcium-binding site III of rabbit skeletal troponin C: effect on the lanthanum affinity of the interchange of aspartic acid and asparagine residues at the metal ion coordinating positions.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Binding Sites; Calcium-Binding Proteins; Kinetics; Lanthanum; Magnetic Resonance Spectroscopy; Peptide Fragments; Rabbits; Thermodynamics; Troponin; Troponin C | 1988 |
Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins.
Topics: Asparagine; Aspartic Acid; Dipeptides; Enzymes; Peptide Fragments; Protein Conformation; Proteins; Succinimides | 1987 |
Evidence for isoaspartyl (deamidated) forms of mouse epidermal growth factor.
Topics: Amino Acid Sequence; Amino Acids; Animals; Asparagine; Aspartic Acid; Chromatography, Gel; Chromatography, High Pressure Liquid; Epidermal Growth Factor; Genetic Variation; Mice; Submandibular Gland | 1987 |
Anaerobically induced genes of Escherichia coli.
Topics: Ammonia; Anaerobiosis; Asparagine; Aspartic Acid; Carbohydrates; Chromosome Mapping; Citrates; Conjugation, Genetic; DNA, Recombinant; Escherichia coli; Genes, Bacterial; Phenotype | 1986 |
Nuclear magnetic resonance study of the state of protonation of inhibitors bound to mutant dihydrofolate reductase lacking the active-site carboxyl.
Topics: Asparagine; Aspartic Acid; Binding Sites; Carbon Isotopes; Escherichia coli; Kinetics; Magnetic Resonance Spectroscopy; Methotrexate; Mutation; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1986 |
Methylation at specific altered aspartyl and asparaginyl residues in glucagon by the erythrocyte protein carboxyl methyltransferase.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Brain; Chymotrypsin; Erythrocytes; Glucagon; Humans; Methylation; Peptide Fragments; Protein Methyltransferases; Protein O-Methyltransferase; S-Adenosylmethionine; Substrate Specificity; Trypsin | 1987 |
Formation of a cyclic imide in aspartyl or asparaginyl glycyl peptides induced by heating in the dry state.
Topics: Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Electrophoresis, Paper; Hot Temperature; Imides; Indicators and Reagents; Mass Spectrometry; Oligopeptides; Peptides, Cyclic; Spectrophotometry | 1987 |
Hemoglobin Alamo [alpha 2 beta 2(19)(B1)Asn----Asp] in a Venezuelan family.
Topics: Amino Acids; Asparagine; Aspartic Acid; Child; Electrophoresis, Cellulose Acetate; Female; Hemoglobins, Abnormal; Humans; Pedigree; Peptide Mapping; Venezuela | 1987 |
Interaction of metabolism of aspartate and inosine and energy state of malignant cells.
Topics: Adenosine Triphosphate; Animals; Asparagine; Aspartic Acid; Carcinoma, Ehrlich Tumor; Cells, Cultured; Energy Metabolism; Glutamine; Inosine; Lactates; Lactic Acid; Mice; Oxygen Consumption; Proline | 1987 |
Age-dependent accumulation of protein residues which can be hydrolyzed to D-aspartic acid in human erythrocytes.
Topics: Asparagine; Aspartic Acid; Blood Proteins; Cytosol; Erythrocyte Aging; Erythrocyte Membrane; Humans; Methylation | 1986 |
Chemical mutations of the catalytic carboxyl groups in lysozyme to the corresponding amides.
Topics: Amino Acids; Asparagine; Aspartic Acid; Chromatography, Affinity; Glutamates; Glutamine; Kinetics; Muramidase; Mutation; Sulfonamides | 1986 |
Effects of alanine on malate-aspartate shuttle in perfused livers from cold-exposed rats.
Topics: Adrenalectomy; Alanine; Alanine Transaminase; Aminooxyacetic Acid; Animals; Asparagine; Aspartic Acid; Cold Temperature; Dexamethasone; Ethanol; Glucose; Lactates; Lactic Acid; Liver; Malates; Male; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Sorbitol | 1986 |
Post-translational methylation of asparaginyl residues. Identification of beta-71 gamma-N-methylasparagine in allophycocyanin.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Methylamines; Methylation; Phycocyanin; Phycoerythrin; Pigments, Biological; Protein Processing, Post-Translational | 1986 |
Methylation of calmodulin at carboxylic acid residues in erythrocytes. A non-regulatory covalent modification?
Topics: Asparagine; Aspartic Acid; Calmodulin; Carboxylic Acids; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Hot Temperature; Humans; Hydrolysis; Methylation; Ribonuclease, Pancreatic | 1986 |
Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Isomerism; Kinetics; Oligopeptides; Proteins; Succinimides | 1987 |
Hb A2 Yokoshima, alpha(2)delta(2)25(B7)Gly----Asp, a new delta chain variant found in a Japanese family.
Topics: Asparagine; Aspartic Acid; Child, Preschool; Chromatography, DEAE-Cellulose; Chromatography, High Pressure Liquid; Female; Hemoglobin A; Hemoglobin A2; Hemoglobins, Abnormal; Humans; Isoelectric Focusing; Japan; Male | 1985 |
A new case of hemoglobin Providence (alpha 2 beta 2 82 (EF6) Lys----Asn or Asp) discovered in a French Caucasian family. Structural and functional studies.
Topics: Adolescent; Adult; Asparagine; Aspartic Acid; Child, Preschool; Female; France; Hemoglobin J; Hemoglobins, Abnormal; Humans; Kinetics; Lysine; Male; Middle Aged; Oxygen; Pedigree; Peptide Fragments; Trypsin; White People | 1985 |
Comparison of reversed-phase and cation-exchange high-performance liquid chromatography for separating closely related peptides: separation of Asp76-human parathyroid hormone (1-84) from Asn76-human parathyroid hormone (1-84).
Topics: Angiotensin II; Asparagine; Aspartic Acid; Bradykinin; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Parathyroid Hormone; Stereoisomerism | 1985 |
Use of the polyethylene glycol adduct of L-asparaginase for the treatment of hyperasparaginemia in a schizophrenic patient.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Asparaginase; Asparagine; Aspartic Acid; Brain; Humans; Male; Polyethylene Glycols; Schizophrenia | 1985 |
The role of aspartic acid and asparagine residues in the aging of erythrocyte proteins: cellular metabolism of racemized and isomerized forms by methylation reactions.
Topics: Asparagine; Aspartic Acid; Blood Proteins; Erythrocyte Aging; Erythrocytes; Humans; Isomerism; Membrane Proteins; Methylation; Stereoisomerism | 1985 |
HB G-Copenhagen or alpha 2 beta 2(47) (CD6) Asp----Asn observed in a black newborn.
Topics: Adolescent; Amino Acid Sequence; Asparagine; Aspartic Acid; Black People; Chromatography, High Pressure Liquid; Female; Hemoglobins, Abnormal; Humans; Infant, Newborn; Peptide Fragments; Trypsin | 1985 |
The activation of Mg++-dependent ATPase by aspartic and glutamic acids.
Topics: Adenosine Triphosphatases; Alanine; Asparagine; Aspartic Acid; Cell Membrane; Cell Membrane Permeability; Depression, Chemical; Enzyme Activation; Erythrocytes; Glutamates; Glutamine; Glycine; Humans; In Vitro Techniques; Leucine; Magnesium; Potassium; Saponins; Serine; Sodium | 1970 |
[Effect of administration of amino acids, especially of L-DOPA and -methyldopa, on the composition of cerebrospinal fluid in extrapyramidal syndromes. 3. Alterations of cerebrospinal fluid in patients with Huntington's chorea after -methyldopa or L-DOPA
Topics: Adult; Aged; Alanine Transaminase; Asparagine; Aspartic Acid; Child; Dihydroxyphenylalanine; Female; Glutamates; Glutamine; Glycine; Humans; Huntington Disease; Male; Methyldopa; Middle Aged; Phenylalanine; Pyruvates; Threonine | 1973 |
Influence of complete ischemia on glycolytic metabolites, citric acid cycle intermediates, and associated amino acids in the rat cerebral cortex.
Topics: Acetone; Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Citrates; Citric Acid Cycle; Fructosephosphates; Fumarates; gamma-Aminobutyric Acid; Glutamates; Glutamine; Glycerophosphates; Ischemia; Ketoglutaric Acids; Malates; Male; Methods; Phosphates; Rats; Succinates | 1974 |
Azotomycin--toxicologic, biochemical and pharmacologic studies in mice.
Topics: Animals; Antibiotics, Antineoplastic; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Ataxia; Azo Compounds; Carbon Radioisotopes; Carboxy-Lyases; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diarrhea; DNA; Formates; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Lethal Dose 50; Ligases; Liver Neoplasms; Malate Dehydrogenase; Mice; Mice, Inbred Strains; Protein Biosynthesis; Seizures; Spleen; Time Factors | 1974 |
Comparison of the amino acid sequences of the variable regions of light chains derived from two homogeneous rabbit anti-pneumococcal antibodies.
Topics: Aconitic Acid; Alanine; Amino Acid Sequence; Amino Acids; Animals; Antibodies, Bacterial; Asparagine; Aspartic Acid; Autoanalysis; Chromatography, Gel; Electrophoresis, Paper; Glutamates; Glycine; Hydrolysis; Immunoglobulin Fragments; Rabbits; Serine; Streptococcus pneumoniae; Threonine; Tyrosine; Valine | 1974 |
Chromatographic analysis of the bleeding sap of inoculated and non-inoculated soya plants.
Topics: Alanine; Amino Acids; Asparagine; Aspartic Acid; Chromatography, Paper; Glutamine; Glycine max; Injections; Leucine; Nitrogen; Rhizobium; Serine; Valine | 1967 |
Aspartylglycosaminuria. An inborn error of metabolism associated with mental defect.
Topics: Adult; Asparagine; Aspartic Acid; Female; Glucosamine; Glucosidases; Glycoproteins; Humans; Intellectual Disability; Male; Metabolism, Inborn Errors; Oligosaccharides; Peptide Hydrolases | 1968 |
The attachment site of carbohydrate in a mouse immunoglobulin light chain.
Topics: Amino Acid Sequence; Amino Acids; Aminopeptidases; Animals; Asparagine; Aspartic Acid; Carbohydrates; Carbon Isotopes; Carboxypeptidases; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Gel; Chromatography, Paper; Chymotrypsin; Electrophoresis; gamma-Globulins; Glycoproteins; Mice; Peptide Biosynthesis; Peptides; Plasmacytoma; Protein Hydrolysates; Tritium; Trypsin | 1969 |
L-asparaginase and blastogenesis.
Topics: Asparaginase; Asparagine; Aspartic Acid; Cell Differentiation; Cell Transformation, Neoplastic; Culture Media; Culture Techniques; Humans; Lymphocytes; Mitosis | 1969 |
Activity of a transfer RNA modifying enzyme during the development of Drosophila and its relationship to the su(s) locus.
Topics: Amino Acyl-tRNA Synthetases; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Thin Layer; Drosophila melanogaster; Genes; Histidine; Metamorphosis, Biological; Models, Biological; Mutation; Oligonucleotides; Ribonucleotides; RNA, Transfer; Spectrophotometry, Ultraviolet; Transcription, Genetic; Tritium; Tyrosine | 1973 |
Effect of L-asparagine on growth of Mycobacterium tuberculosis and on utilization of other amino acids.
Topics: Aerobiosis; Alanine; Ammonium Chloride; Asparagine; Aspartic Acid; Autoanalysis; Culture Media; Glutamates; Mycobacterium tuberculosis; Spectrophotometry; Stereoisomerism | 1974 |
Formation of asparagine from aspartic acid in rat brain.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Ammonium Chloride; Animals; Animals, Newborn; Asparaginase; Asparagine; Aspartic Acid; Brain; Carbon Isotopes; Centrifugation; Chromatography; Electrophoresis; Glucose; Glutamine; Hydrogen-Ion Concentration; Male; Mitochondria; Rats | 1970 |
Preparation and properties of smooth muscle myosin from horse esophagus.
Topics: Adenosine Triphosphatases; Amino Acids; Animals; Asparagine; Aspartic Acid; Calcium; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Edetic Acid; Enzyme Activation; Esophagus; Ethylmaleimide; Glycine; Horses; Leucine; Lysine; Magnesium; Muscle Proteins; Muscle, Smooth; Muscles; Organ Specificity; Osmolar Concentration; Phosphorus; Potassium Chloride; Proline; Rabbits; Sulfhydryl Compounds; Temperature; Ultracentrifugation | 1970 |
The population-dependent requirement by cultured mammalian cells for metabolites which they can synthesize. II. Glutamic acid and glutamine; aspartic acid and asparagine.
Topics: Animals; Asparagine; Aspartic Acid; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Culture Techniques; Glucose; Glutamates; Glutamine; Liver Neoplasms; Rats; Sarcoma, Experimental | 1966 |
Asparagine biosynthesis by the Novikoff Hepatoma isolation, purification, property, and mechanism studies of the enzyme system.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Ammonium Chloride; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Carcinoma, Hepatocellular; Diphosphates; Female; Glutamine; Hydrogen-Ion Concentration; Hydroxamic Acids; Hydroxylamines; Liver Neoplasms; Magnesium; Manganese; Neoplasms, Experimental; Potassium; Rats | 1968 |
[Study of B.S.P. metabolites and some histo-enzymologic modifications under the influence of aspartic acid].
Topics: Acid Phosphatase; Adenosine Triphosphatases; Amino Acids; Animals; Asparagine; Aspartic Acid; Bilirubin; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Esterases; Glucose-6-Phosphatase; Hepatitis; Histocytochemistry; Humans; Lipid Metabolism; Liver; Liver Function Tests; Nucleic Acids; Oxidoreductases; Rats; Sulfobromophthalein | 1967 |
Plasma "angiotensinase" activity as a determinant of angiotensin pressor action and tachyphylaxis in the rat.
Topics: Angiotensin II; Animals; Asparagine; Aspartic Acid; Blood Pressure; Endopeptidases; Kidney; Nephrectomy; Peptides; Rats; Tachyphylaxis; Time Factors | 1968 |
Beta-aspartylhydroxamic acid: its action as a feedback inhibitor and a repressor of asparagine synthetase in Lactobacillus arabinosus.
Topics: Adenosine Triphosphate; Antimetabolites; Asparagine; Aspartic Acid; Cell-Free System; Depression, Chemical; Diphosphates; Enzyme Repression; Feedback; Glutamates; Hydroxamic Acids; Hydroxylamines; Lactobacillus; Ligases; Phosphorus Isotopes; RNA, Bacterial; RNA, Transfer; Time Factors | 1969 |
Sources of nitrogen as rate-limiting factors for purine biosynthesis de novo in Ehrlich ascites tumor cells.
Topics: Adenine; Ammonia; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Diphosphates; Drug Synergism; Glutamine; Glycine; Hypoxanthines; Kinetics; Ligases; Methionine Sulfoximine; Nitrogen; Nucleotides; Pentosephosphates; Purines; Transferases | 1969 |
An enzymatic method for the measurement of asparagine and a new assay of asparaginase activity.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Chemical Phenomena; Chemistry; Escherichia coli; Humans; Indicators and Reagents; Ketoglutaric Acids; Malate Dehydrogenase; Methods; NAD | 1969 |
Behavior of angiotensin octapeptides and dinitrophenyl-angiotensin during chromatography on polyacrylamide and dextran gels.
Topics: Angiotensin II; Asparagine; Aspartic Acid; Bacitracin; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography; Dextrans; Dinitrophenols; Gels; Histidine; Hydrogen-Ion Concentration | 1970 |
The altered patterns of transfer RNA in SV40-infected and transformed cells.
Topics: Acylation; Amino Acids; Amino Acyl-tRNA Synthetases; Ammonium Sulfate; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Cell Line; Cell Transformation, Neoplastic; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; DNA, Viral; Electron Transport; Haplorhini; Histidine; Kidney; Nucleic Acid Hybridization; Ribosomes; RNA, Transfer; Simian virus 40; Tritium | 1972 |
Production of L-asparagine by tumor cells and the effect of asparagine analogs.
Topics: Amino Acids; Animals; Asparaginase; Asparagine; Aspartic Acid; Azo Compounds; Bromine; Carbon Isotopes; Carcinoma, Hepatocellular; Chlorine; Glutamine; Kinetics; Leukemia, Experimental; Liver Neoplasms; Lymphoma, Non-Hodgkin; Mast Cells; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Sarcoma 180 | 1972 |
Binding of triphosphate spin labels to hemoglobin Kempsey.
Topics: Adenosine Triphosphate; Asparagine; Aspartic Acid; Binding Sites; Cyanides; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Hemoglobins, Abnormal; Humans; Macromolecular Substances; Mathematics; Oxygen; Phosphoric Acids; Piperidines; Protein Binding | 1972 |
The examination of the presence of amide groups in glutamic acid and aspartic acid residues of staphylococcal nuclease (Foggi strain).
Topics: Amino Acid Sequence; Amino Acids; Aminopeptidases; Asparagine; Aspartic Acid; Chromatography, Ion Exchange; Chromatography, Thin Layer; Glutamates; Glutamine; Molecular Weight; Peptides; Phosphoric Monoester Hydrolases; Staphylococcus; Thiocyanates; Trypsin | 1972 |
Stereospecificity of the dihydroorotate-dehydrogenase reaction.
Topics: Asparagine; Aspartic Acid; Bacteria; Benzyl Compounds; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Thin Layer; Deuterium; Esters; Ethanol; Hydrogen; Kinetics; Magnetic Resonance Spectroscopy; NAD; Orotic Acid; Oxidation-Reduction; Oxidoreductases; Structure-Activity Relationship | 1972 |
The amino acid sequence of cytochrome c-553 from the Chrysophycean alga Monochrysis lutheri.
Topics: Amino Acid Sequence; Amino Acids; Animals; Asparagine; Aspartic Acid; Autoanalysis; Bacteria; Chymotrypsin; Cysteine; Cytochrome c Group; Dansyl Compounds; Electron Transport; Eukaryota; Glycine; Horses; Hydrolysis; Mitochondria, Muscle; Pepsin A; Peptides; Photosynthesis; Species Specificity; Thiocyanates; Time Factors; Trypsin | 1972 |
Nuclear magnetic resonance and spin-label studies of hemoglobin Kempsey.
Topics: Asparagine; Aspartic Acid; Australia; Carboxyhemoglobin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Heme; Hemoglobins; Hemoglobins, Abnormal; Humans; Inositol; Iodoacetates; Ligands; Magnetic Resonance Spectroscopy; Mutation; Organophosphorus Compounds; Piperidines; Protein Conformation; Spin Labels | 1973 |
Sequence data: magnitude and implications of some ambiguities.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Biological Evolution; Cytochrome c Group; Fibrin; Glutamates; Glutamine; Hemoglobins; Horses; Mutation; Peptides; Plants; Swine | 1972 |
Triphosphate spin-label studies of allosteric interactions in hemoglobin.
Topics: Adenosine Triphosphate; Allosteric Regulation; Arginine; Asparagine; Aspartic Acid; Australia; Binding Sites; Cyanides; Electron Spin Resonance Spectroscopy; Ferricyanides; Glycerophosphates; Hemoglobins; Hemoglobins, Abnormal; Humans; Kinetics; Leucine; Maryland; Mathematics; Models, Biological; Mutation; Phosphoric Acids; Piperidines; Protein Binding; Protein Conformation; Spin Labels | 1973 |
Radical yield in X-irradiated biological molecules. II. Naturally-occurring amino-acids.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cysteine; Cystine; Electron Spin Resonance Spectroscopy; Free Radicals; Glutamates; Histamine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Radiation Effects; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1974 |
Human glucose 6-phosphate dehydrogenase: purification and characterization of Negro type variant (A+) and comparison with normal enzyme (B+).
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Black People; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis; Erythrocytes; Glucosephosphate Dehydrogenase; Guanidines; Humans; Hydrogen-Ion Concentration; Immune Sera; Immunodiffusion; Isoenzymes; Kinetics; Magnesium; Male; Molecular Weight; NAD; NADP; Rabbits; Ultracentrifugation | 1967 |
Purification, properties, and identity of liver mitochondrial tyrosine aminotransferase.
Topics: Amino Acids; Animals; Antibodies; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Chemical Phenomena; Chemistry, Physical; Chromatography, Gel; Crystallization; Cysteine; Cytoplasm; Diffusion; Dihydroxyphenylalanine; Fenclonine; Glutamates; Isoelectric Focusing; Isoenzymes; Ketoglutaric Acids; Male; Methionine; Mitochondria, Liver; Molecular Weight; Monoiodotyrosine; Oxaloacetates; Phenylpyruvic Acids; Rats; Stereoisomerism; Tryptophan; Tyrosine; Tyrosine Transaminase; Ultracentrifugation; Vibration | 1971 |
Conversion of the alpha-hydroxy and alpha-keto analogues of methionine to methionine by cell-free extracts of adult female Ascaris suum.
Topics: Ascaris; Asparagine; Aspartic Acid; Butyrates; Cell-Free System; Female; Glutamates; Glutamine; Methionine; NAD; NADP; Oxidation-Reduction; Proteins | 1971 |
Carbamyl phosphate and glutamine stimulation of the gallbladder salt pump.
Topics: Acetates; Animals; Asparagine; Aspartic Acid; Azaserine; Bicarbonates; Biological Transport, Active; Carbamates; Gallbladder; Glutamates; Glutamine; Hydrogen-Ion Concentration; Kinetics; Organophosphorus Compounds; Rabbits; Sodium Chloride; Water | 1974 |
Haemoglobin F auckland G gamma 7 Asp leads to Asn: further evidence for multiple genes for the gamma chain.
Topics: Amino Acid Sequence; Amino Acids; Asparagine; Aspartic Acid; Chromatography, Ion Exchange; Female; Fetal Hemoglobin; Genes; Genetic Variation; Hemoglobins, Abnormal; Humans; Indicators and Reagents; Infant, Newborn; Male; New Zealand; Ninhydrin; Peptide Fragments; Pregnancy; United Kingdom | 1974 |
The glycoasparagines in urine of a patient with aspartylglycosaminuria.
Topics: Asparagine; Aspartic Acid; Chromatography, Gas; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Paper; Female; Glucosamine; Glycopeptides; Glycosuria; Humans; Hydrogen-Ion Concentration; Metabolism, Inborn Errors; Models, Chemical | 1974 |
Further characterization of two co-lipases from porcine pancreas.
Topics: Amino Acid Sequence; Amino Acids; Animals; Asparagine; Aspartic Acid; Electrophoresis, Disc; Glutamates; Glutamine; Hydrogen-Ion Concentration; Isoenzymes; Lipase; Molecular Weight; Pancreas; Swine | 1974 |
Production of L-asparaginase by Pseudomonas ovalis.
Topics: Asparaginase; Asparagine; Aspartic Acid; Egypt; Enzyme Induction; Glutamates; Hydrogen-Ion Concentration; Pseudomonas; Soil Microbiology; Stereoisomerism | 1974 |
Deamidation in vivo of an asparagine residue of rabbit muscle aldolase.
Topics: Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Chemical Phenomena; Chemistry; Chymotrypsin; Fructose-Bisphosphate Aldolase; Half-Life; Isoelectric Focusing; Isoleucine; Isotope Labeling; Macromolecular Substances; Mathematics; Muscles; Peptides; Rabbits | 1972 |
High-resolution proton NMR studies of low affinity hemoglobins.
Topics: Asparagine; Aspartic Acid; Binding Sites; Carbon Isotopes; Deuterium; Hemoglobins, Abnormal; Histidine; Humans; Hydrogen-Ion Concentration; Iron; Japan; Kansas; Magnetic Resonance Spectroscopy; Methylation; Mutation; Oxyhemoglobins; Protein Binding; Protein Conformation; Threonine; Tyrosine | 1973 |
Possible anticodon sequences of tRNA His , tRNA Asm , and tRNA Asp from Escherichia coli B. Universal presence of nucleoside Q in the first postion of the anticondons of these transfer ribonucleic acids.
Topics: Asparagine; Aspartic Acid; Base Sequence; Carbon Isotopes; Chromatography, Ion Exchange; Escherichia coli; Genetic Code; Histidine; Nucleosides; Polynucleotides; Protein Binding; Ribonucleases; Ribosomes; RNA, Bacterial; RNA, Transfer; Spectrophotometry; Stimulation, Chemical | 1972 |
Stereospecific features of the conformative response of L-asparaginase.
Topics: Asparaginase; Asparagine; Aspartic Acid; Binding Sites; Drug Stability; Escherichia coli; Hot Temperature; Hydrogen-Ion Concentration; Iodine; Kinetics; Mathematics; Protein Conformation; Stereoisomerism; Structure-Activity Relationship; Trypsin | 1972 |
Erwinia carotovora asparaginase in patients with prior anaphylaxis to asparaginase from E. coli.
Topics: Adult; Aged; Anaphylaxis; Asparaginase; Asparagine; Aspartic Acid; Daunorubicin; Drug Hypersensitivity; Erwinia; Escherichia coli; Female; Half-Life; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Prednisone; Vincristine | 1972 |
[Kinetic studies on the reaction mechanism of asparaginase from Escherichia coli B].
Topics: Asparaginase; Asparagine; Aspartic Acid; Escherichia coli; Hydrolysis; Hydroxamic Acids; Kinetics | 1972 |
The pH dependence and quenching of the fluorescence of asparaginase from Escherichia coli B.
Topics: Asparaginase; Asparagine; Aspartic Acid; Binding Sites; Escherichia coli; Fluorescence; Histidine; Hydrogen-Ion Concentration; Protein Conformation; Spectrometry, Fluorescence; Time Factors; Tryptophan | 1972 |
Heterogeneous changes in amino acid transport activity in E. coli lipid overproducing mutants.
Topics: Amino Acids; Asparagine; Aspartic Acid; Biological Transport, Active; Carbon Isotopes; Escherichia coli; Glutamates; Kinetics; Lipids; Mutation; Proline | 1973 |
Conversion of exposed aspartyl and glutamyl residues in proteins to asparaginyl and glutaminyl residues.
Topics: Amides; Ammonium Chloride; Animals; Asparaginase; Asparagine; Aspartic Acid; Autoanalysis; Carbodiimides; Cattle; Chymotrypsin; Chymotrypsinogen; Escherichia coli; Esters; Glutamates; Glutamine; Glycine; Muramidase; Pancreas; Pepsin A; Protein Conformation; Proteins; Ribonucleases; Spectrophotometry; Stomach; Swine; Trypsin | 1973 |
The acidic amino-acid permease of Aspergillus nidulans.
Topics: Amino Acids; Asparagine; Aspartic Acid; Aspergillus nidulans; Azides; Biological Transport, Active; Carbon Isotopes; Chromatography; Cyanides; Glutamates; Histidine; Hydrogen-Ion Concentration; Kinetics; Membrane Transport Proteins; Phenylalanine; Sulfur Isotopes; Temperature; Valinomycin | 1973 |
Isoacceptor tRNAs for glutamate, glutamine, aspartate and asparagine in calf brain.
Topics: Animals; Asparagine; Aspartic Acid; Brain; Carbon Radioisotopes; Cattle; Chromatography; Chromatography, Gel; Escherichia coli; Glutamates; Glutamine; Humans; Liver; Liver Regeneration; Lymphocytes; Male; Mice; Neoplasms, Experimental; Organ Specificity; Plasmacytoma; Rats; RNA, Transfer; Species Specificity; Spectrophotometry, Ultraviolet | 1974 |
Asparagine utilization in Escherichia coli.
Topics: Ammonia; Anaerobiosis; Asparaginase; Asparagine; Aspartic Acid; Azo Compounds; Bacterial Proteins; Carbon Radioisotopes; Chromatography, Thin Layer; Culture Media; Cytoplasm; Densitometry; Escherichia coli; Glutamine; Mutation; Stereoisomerism; Valerates | 1974 |
In vitro assembly of L-asparaginase subunits.
Topics: Asparaginase; Asparagine; Aspartic Acid; Escherichia coli; Hydrogen-Ion Concentration; Hydrolysis; Macromolecular Substances; Protein Conformation; Protein Denaturation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Stereoisomerism; Time Factors; Tryptophan; Tyrosine; Ultracentrifugation; Urea | 1974 |
[Asparaginase activity of some bacteria].
Topics: Asparaginase; Asparagine; Aspartic Acid; Bacillus subtilis; Culture Media; Enzyme Induction; Escherichia coli; Mycobacterium; Pseudomonas | 1972 |
[Metabolic products of microorganisms. 96. Mechanism of action of the macrolide-type antibiotic, chlorothricin. I. Inhibitor of the pyruvate carboxylase from Bacillus subtilis].
Topics: Acetates; Anti-Bacterial Agents; Asparagine; Aspartic Acid; Bacillus subtilis; Carbon Dioxide; Carbon Isotopes; Culture Media; Glucose; Ligases; Pyruvates; Time Factors | 1972 |
Human carbonic anhydrases. 8. Isolation and characterization of polymorphic form of a C type isozyme.
Topics: Amino Acids; Asparagine; Aspartic Acid; Black People; Carbonic Anhydrases; Chromatography, Gel; Chymotrypsin; Crystallization; Electrophoresis, Paper; Electrophoresis, Starch Gel; Erythrocytes; Heterozygote; Homozygote; Humans; Hydrogen-Ion Concentration; Isoelectric Focusing; Isoenzymes; Molecular Weight; Peptides; Trypsin; Zinc | 1972 |
Hemoglobin 3 chains in apes. Primary structures and the presumptive nature of back mutation in a normally silent gene.
Topics: Alleles; Amino Acid Sequence; Amino Acids; Animals; Asparagine; Aspartic Acid; Chromosome Mapping; Computers; Cross Reactions; Genes; Genetic Code; Hemoglobins; Hominidae; Immunodiffusion; Male; Mutation; Pan troglodytes; Peptides; Rabbits; Serine; Species Specificity; Suppression, Genetic; Tritium; Trypsin | 1973 |
Amino acids and L-asparaginase activity in the plasma of owl monkeys (Aotus trivirgatus).
Topics: Amino Acids; Animals; Asparaginase; Asparagine; Aspartic Acid; Blood Proteins; Blood Urea Nitrogen; Creatinine; Female; Haplorhini; Male; Methylhistidines | 1972 |
Glycoasparagines in the urine of patients with aspartylglycosaminuria.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Asparagine; Aspartic Acid; Chromatography; Chromatography, Ion Exchange; Fucose; Galactose; Humans; Hydrogen-Ion Concentration; Intellectual Disability; Molecular Weight | 1972 |
Carboxyl group modification and amide assignments in automated sequencing of proteins.
Topics: Amino Acid Sequence; Amino Acids; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Esters; Glutamates; Glutamine; Glycine; Hydrolysis; Imines; Methanol; Methods; Methylamines; Ribonucleases; Serine; Thiazoles | 1972 |
[Urinary excretion of asparagne and aspartate in control subjects and patients with cancer before and after treatment with K-Mg-aspartate].
Topics: Adolescent; Adult; Aged; Asparagine; Aspartic Acid; Breast Neoplasms; Cholecystitis; Female; Humans; Magnesium; Male; Middle Aged; Neoplasms; Potassium; Stomach Neoplasms | 1972 |
On the regulation of asparaginase synthesis in Pseudomonas Boreopolis 526.
Topics: Asparaginase; Asparagine; Aspartic Acid; Enzyme Induction; Enzyme Repression; Glutaminase; Kinetics; Pseudomonas | 1972 |
Amino acids and peptides. 34. Synthesis of a structure related to scotophobin.
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspartic Acid; Glutamine; Glycine; Lysine; Memory; Peptides; Serine; Tyrosine | 1972 |
[N-acetyl-alpha-l-aspartyl-l-glutamate and N-acetyl-l-asparaginic acid in different divisions of rat brain under hyperoxia].
Topics: Animals; Asparagine; Aspartic Acid; Brain Chemistry; Glutamates; Partial Pressure; Rats | 1972 |
A radiometric technique for measuring L-asparagine in picomole quantities.
Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Carbon Isotopes; Glutamates; Glutarates; Humans; Hydrogen-Ion Concentration; Methods; Mice; Microchemistry; Pituitary Gland; Succinimides | 1972 |
Effect of D-alanine and D-aspartic acid on the chick.
Topics: Alanine; Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Asparagine; Aspartic Acid; Body Weight; Chickens; Diet; Dietary Proteins; Dose-Response Relationship, Drug; Drug Synergism; Glutamates; Glycine max; Growth; Plant Proteins; Serine; Stereoisomerism; Structure-Activity Relationship; Vitamins | 1972 |
[Demonstration of tumor-induced amino acid changes in the extracellular fluid using two-way separation by high voltage electrophoresis followed by chromatography].
Topics: Amino Acids; Aminobutyrates; Animals; Asparagine; Aspartic Acid; Chromatography; Cystine; Electrophoresis; Extracellular Space; Glutamates; Glutamine; Rats; Sarcoma, Yoshida; Serine; Threonine | 1972 |
[Asparagine and aspartic acid degradation in Enterobacteriaceae].
Topics: Asparagine; Aspartic Acid; Enterobacteriaceae; Klebsiella | 1972 |
Effect of pentobarbital on amino acid and urea flux in the isolated dog brain.
Topics: Amino Acids; Anesthesia, General; Animals; Asparagine; Aspartic Acid; Brain; Cerebrovascular Circulation; Dipeptides; Dogs; Glutamates; Glutamine; Glycine; Halothane; Isoleucine; Leucine; Methoxyflurane; Nitrogen; Pentobarbital; Proline; Serine; Taurine; Urea; Valine | 1973 |
Hepatic regulation of plasma L-asparagine.
Topics: Animals; Asparagine; Aspartic Acid; Biological Transport, Active; Carbon Isotopes; Choline; Diazooxonorleucine; Dinitrophenols; In Vitro Techniques; Liver; Male; Models, Biological; Rats; Sodium; Time Factors | 1973 |
[Asparagine and aspartic acid metabolism in Corynebacterium sepedonicum (Spieck. et Kott.) Skapt. et Burkh].
Topics: Asparagine; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Citric Acid Cycle; Corynebacterium; Culture Media; Malonates; Methionine; Plant Diseases; Vegetables | 1973 |
Incorporation of 14 C from (U- 14 C)glucose into free amino acids in mouse brain loci in vivo under normal conditions.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Asparagine; Aspartic Acid; Autoradiography; Brain; Carbon Isotopes; Cerebral Cortex; Chromatography, Gas; Densitometry; Female; Glucose; Glutamates; Glutamine; Glycine; Hippocampus; Hypothalamus; Kinetics; Male; Mice; Thalamus | 1973 |
Identification of asparagine as the site of glycosylation in glycoprotein biosynthesis.
Topics: Animals; Asparagine; Aspartic Acid; Binding Sites; Female; Glycoproteins; Protein Conformation; Rats; Tritium | 1973 |
Amino acid levels in plasma, liver, and skeletal muscle during protein deprivation.
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; Body Weight; Glutamates; Glutamine; Glycine; Isoleucine; Leucine; Liver; Male; Methionine; Muscles; Organ Size; Phenylalanine; Protein Deficiency; Rats; Serine; Threonine; Time Factors; Tyrosine; Valine | 1973 |
The free and bound amino acids removed by hemodialysis.
Topics: Adult; Alanine; Amino Acids; Asparagine; Aspartic Acid; Blood Flow Velocity; Blood Glucose; Body Weight; Cystine; Fasting; Female; Freeze Drying; Glucose; Glutamine; Glycine; Humans; Hydrolysis; Kidneys, Artificial; Male; Methionine; Middle Aged; Molecular Weight; Proline; Renal Dialysis; Uremia | 1973 |
Models for the gelling behavior of binary mixtures of hemoglobin variants.
Topics: Asparagine; Aspartic Acid; Gels; Glutamates; Hemoglobin C; Hemoglobin, Sickle; Hemoglobins, Abnormal; Humans; Macromolecular Substances; Mathematics; Models, Chemical; Protein Conformation; Solubility; Valine | 1973 |
In vivo and in vitro studies on asparagine biosynthesis in soybean seedlings.
Topics: Amino Acids; Asparagine; Aspartic Acid; Carbon Isotopes; Cell Fractionation; Chromatography, Ion Exchange; Chromatography, Paper; Chromatography, Thin Layer; Cyanides; Fumarates; Glycine max; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Ligases; Malates; Plant Cells; Plants; Subcellular Fractions; Succinates; Sulfhydryl Reagents; Time Factors; Tritium | 1973 |
The measurement of 4-( 14 C)-L-asparagine in body fluids and tissues: methodology and application.
Topics: Amination; Animals; Asparaginase; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Carbon Isotopes; Cyclophosphamide; Decarboxylation; Diet; Dogs; Female; Hydrolysis; Ketoglutaric Acids; Lymphoma; Lymphoma, Non-Hodgkin; Malate Dehydrogenase; Methods; Neoplasms, Experimental; Pronase; Proteins; Zinc | 1973 |
Effect of asparagine on growth and protein synthesis in weanling rats.
Topics: Administration, Oral; Animal Feed; Animals; Asparagine; Aspartic Acid; Carbon Radioisotopes; Caseins; Citrates; Injections, Intraperitoneal; Leucine; Liver; Male; Muscles; Nutritional Requirements; Protein Biosynthesis; Protein Hydrolysates; Quaternary Ammonium Compounds; Rats; Weaning | 1973 |
Hemoglobin G Waimanalo: alpha-64 Asp leads to Asn.
Topics: Aged; Amino Acid Sequence; Amino Acids; Asparagine; Aspartic Acid; Cyanogen Bromide; Female; Hawaii; Hemoglobins, Abnormal; Humans; Infant; Male; Peptide Fragments; Peptides; Spectrophotometry; Trypsin | 1973 |
Carbon 13 nuclear magnetic resonance of pentapeptides of glycine containing central residues of serine, threonine, aspartic and glutamic acids, asparagine, and glutamine.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Carbon Isotopes; Chemical Phenomena; Chemistry; Computers; Fourier Analysis; Glutamates; Glutamine; Glycine; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Mathematics; Oligopeptides; Protons; Serine; Threonine; Time Factors | 1973 |
Comparative effects of casein and amino acid mixture simulating casein on growth and food intake in rats.
Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Asparagine; Aspartic Acid; Body Weight; Caseins; Diet; Dietary Proteins; Evaluation Studies as Topic; Feeding Behavior; Glutamates; Glutamine; Male; Metabolism; Nitrogen; Nutritional Requirements; Rats; Structure-Activity Relationship | 1973 |
In vitro synthesis of a specific protein viz. Asparagine synthetase by nuclear fraction from gamma irradiated potato buds.
Topics: Ammonia; Asparagine; Aspartic Acid; Carbon Radioisotopes; Cell Nucleus; Cycloheximide; Dactinomycin; Enzyme Induction; Hydroxamic Acids; Leucine; Ligases; Plant Cells; Plants; Puromycin; Radiation Effects | 1973 |
[Characteristics of asparaginase and glutaminase synthesis in Ps. boreopolis 526].
Topics: Asparaginase; Asparagine; Aspartic Acid; Glutamates; Glutaminase; Glutamine; Ligases; Pseudomonas | 1973 |
Asparagine-requiring tumor cell lines and their non-requiring variants: cytogenetics, biochemistry and population dynamics.
Topics: Ammonia; Animals; Asparagine; Aspartic Acid; Azaguanine; Carcinoma 256, Walker; Cell Division; Cell Line; Cell Survival; Chromosomes; Clone Cells; Cricetinae; Drug Resistance; Female; Genes; Genetic Variation; Genetics, Population; Hybrid Cells; Ligases; Ovary; Rats; Sarcoma, Experimental; Time Factors | 1973 |
Therapeutic properties of a new glutaminase-asparaginase preparation and the influence of the lactate dehydrogenase-elevating virus.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glutamates; Glutaminase; Glutamine; Half-Life; Hydrogen-Ion Concentration; Isoelectric Focusing; L-Lactate Dehydrogenase; Leukemia, Experimental; Mice; Mice, Inbred C57BL; RNA Viruses | 1974 |
Recovery of amino acids and tRNA after scintillation counting of radioactive aminoacyl-tRNA in filter paper strips.
Topics: Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Asparagine; Aspartic Acid; Brain; Carbon Radioisotopes; Carbonates; Cattle; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Evaluation Studies as Topic; Glutamates; Glutamine; Lysine; Male; Methionine; Methods; Paper; Quaternary Ammonium Compounds; RNA, Transfer; Time Factors | 1974 |
[Comments on a geriatric drug].
Topics: Aged; Asparagine; Aspartic Acid; Dementia; Drug Combinations; Female; Hematoporphyrins; Humans; Magnesium; Male; Orotic Acid; Potassium; Procaine | 1974 |
L-Asparaginase production by the rumen anaerobe Vibrio succinogenes.
Topics: Anaerobiosis; Animals; Asparaginase; Asparagine; Aspartic Acid; Carbon Radioisotopes; Cell-Free System; Culture Media; Electron Transport; Fumarates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Malates; Nitrates; Rumen; Stereoisomerism; Succinates; Vibrio | 1974 |
Biotin deficiency in Nigrospora oryzae.
Topics: Asparagine; Aspartic Acid; Biotin; Culture Media; Edible Grain; Filtration; Hot Temperature; Mitosporic Fungi; Nitrates; Plant Growth Regulators; Saccharomyces; Sterilization; Urea | 1974 |
Studies on the mechanism of tumor inhibition by L-asparaginase. Effects of the enzyme on asparagine levels in the blood, normal tissues, and 6C3HED lymphomas of mice: differences in asparagine formation and utilization in asparaginase-sensitive and -resis
Topics: Amino Acids; Animals; Asparaginase; Asparagine; Aspartic Acid; Cell-Free System; Culture Techniques; Escherichia coli; Female; Glutamine; Leucine; Lymphoma; Male; Mice; Neoplasm Proteins; Neoplasms, Experimental; Rabbits; Rats | 1968 |
Asparagine synthesis in guinea-pig liver.
Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Carbon Isotopes; Centrifugation; Chemical Precipitation; Chromatography, Thin Layer; Escherichia coli; Guinea Pigs; Liver; Male | 1968 |
Suppressor selectrion for amino acid replacements expected on the basis of the genetic code.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Bacterial Proteins; Escherichia coli; Genes; Genetic Code; Genetics, Microbial; Glutamates; Glycine; Histidine; Hydro-Lyases; Isoleucine; Leucine; Lysine; Methionine; Mutation; Nucleotides; Phenylalanine; RNA, Messenger; Serine; Suppression, Genetic; Threonine; Tyrosine; Valine | 1967 |
Regeneration, tumor, dietary, and L-asparaginase effects on asparagine biosynthesis in rat liver.
Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Escherichia coli; Female; Ligases; Liver; Liver Neoplasms; Liver Regeneration; Nutritional Requirements; Organ Size; Rats; Spleen | 1969 |
The asparagine synthetase of Escherhic coli. I. Biosynthetic role of the enzyme, purification, and characterization of the reaction products.
Topics: Adenosine Triphosphate; Asparagine; Aspartic Acid; Carbon Isotopes; Cellulose; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Chromosome Mapping; Depression, Chemical; Electrophoresis; Enzyme Repression; Escherichia coli; Hydrogen-Ion Concentration; Ligases; Mercaptoethanol; Methods; Molecular Weight; Mutation; Osmosis | 1969 |
The asparagine synthetase of Escherichia coli. II. Studies on mechanism.
Topics: Acetates; Adenine Nucleotides; Adenosine Triphosphate; Ammonia; Asparagine; Aspartic Acid; Carbon Isotopes; Chemical Phenomena; Chemistry; Escherichia coli; Hot Temperature; Iodoacetates; Kinetics; Ligases; Magnesium; Oxygen Isotopes; Phosphorus Isotopes | 1969 |
Subunit structure of L-asparaginase from Escherichia coli B.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Cysteine; Detergents; Electrophoresis; Escherichia coli; Ethanol; Formamides; Guanidines; Hydrogen-Ion Concentration; Lymphoma; Methods; Microscopy, Electron; Molecular Weight; Sodium Chloride; Sulfates; Ultracentrifugation; Urea | 1969 |
L-asparaginase synthesis by Escherichia coli B.
Topics: Asparaginase; Asparagine; Aspartic Acid; Copper; Culture Media; Escherichia coli; Glucose; Glutamine; Glycerol; Iron; Manganese; Monosaccharides; Temperature; Zinc | 1969 |
Biochemical and pharmacological studies with asparaginase in man.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Colonic Neoplasms; Escherichia coli; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Melanoma; Metabolic Clearance Rate; Middle Aged; Multiple Myeloma; Neoplasms; Neuroblastoma; Osteosarcoma | 1970 |
A rapid radioactive assay for glutamine synthetase, glutaminase, asparagine synthetase, and asparaginase.
Topics: Asparaginase; Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography, Ion Exchange; Escherichia coli; Glutamates; Glutaminase; Glutamine; Ligases | 1970 |
Amino acids of the 6C3HED lymphosarcoma following treatment with asparaginase.
Topics: Amino Acids; Ammonia; Animals; Asparaginase; Asparagine; Aspartic Acid; Escherichia coli; Female; Glutamates; Glutamine; Glycine; Liver; Lymphoma, Non-Hodgkin; Mice; Neoplasms, Experimental; Spleen | 1970 |
l-asparaginase resistance in human leukemia--asparagine synthetase.
Topics: Acute Disease; Asparaginase; Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography; Chronic Disease; Escherichia coli; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Ligases; Time Factors | 1969 |
Analysis of amino acid replacements resulting from frameshift and missense mutations in the tryptophan synthetase A gene of Escherichia coli.
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspartic Acid; Escherichia coli; Genetic Code; Glycine; Ligases; Mutation; Peptides; Suppression, Genetic; Tryptophan; Valine | 1968 |
[Effect of L-asparaginase from Escherichia coli on the phytohemagglutinin stimulated lymphocyte cultures].
Topics: Asparaginase; Asparagine; Aspartic Acid; Culture Techniques; Depression, Chemical; Escherichia coli; Glutamine; Humans; Lectins; Lymphocytes; Mitosis; Stimulation, Chemical; Time Factors | 1970 |
Asparaginyl-transfer RNA: a substrate for L-asparaginase.
Topics: Amino Acyl-tRNA Synthetases; Asparaginase; Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography, DEAE-Cellulose; Chromatography, Gel; Electrophoresis, Paper; Escherichia coli; Kinetics; RNA, Transfer | 1971 |
An extra-corporeal shunt apparatus for blood detoxification.
Topics: Animals; Antibodies; Antigen-Antibody Reactions; Antigens; Asparagine; Aspartic Acid; Autoanalysis; Blood; Dogs; Enzymes; Humans; Immune Sera; Kidney Transplantation; Renal Dialysis; Solubility | 1971 |
Studies of resistance to L-asparaginase in human leukemia.
Topics: Asparaginase; Asparagine; Aspartic Acid; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Drug Resistance; Escherichia coli; Glutamine; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocyte Count; Leukocytes; Ligases | 1970 |
D-Alanine-D-glutamate transaminase. I. Purification and characterization.
Topics: Alanine; Aminobutyrates; Apatites; Asparagine; Aspartic Acid; Bacillus subtilis; Chemical Phenomena; Chemistry; Chromatography; Dextrans; Electrophoresis; Glutamates; In Vitro Techniques; Methionine; Ornithine; Pyridoxine; Serine; Transaminases; Ultracentrifugation | 1965 |
"Dysgonic" strains of mycobacterium tuberculosis on Ogawa's egg medium isolated as pathogens from patients suffering from lung tuberculosis. II. Growth-inhibitory effects of D-asparagine, D-aspartic acid, Dl-serine, or L-serine against "dysgonic".
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Culture Media; Depression, Chemical; Glutamine; Histidine; Humans; Leucine; Mycobacterium tuberculosis; Proline; Serine; Tuberculosis, Pulmonary; Valine | 1967 |
Asparatic acid as a precursor for niacin synthesis by tubercle bacilli grown on 7H-10 agar medium.
Topics: Agar; Aminosalicylic Acids; Asparagine; Aspartic Acid; Bacteriological Techniques; Isoniazid; Mycobacterium tuberculosis; Nicotinic Acids; Streptomycin | 1968 |
Cyanide metabolism by Bacillus megaterium.
Topics: Amino Acids; Asparagine; Aspartic Acid; Bacillus megaterium; Carbon Dioxide; Carbon Isotopes; Cell-Free System; Chromatography, Paper; Culture Media; Cyanides; Electrophoresis; Models, Biological; Paper; Radioisotopes; Serine; Soil Microbiology | 1969 |
[Effects of various amino acids on the sensitivity of 11 strains of Staphylococcus aureus to penicillin G].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cysteine; Glycine; Isoleucine; Leucine; Methionine; Penicillin G; Penicillin Resistance; Staphylococcus; Stereoisomerism; Tryptophan; Valine | 1969 |
Circulatory L-asparaginase activity in primates.
Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Guinea Pigs; Haplorhini; Hominidae; Humans | 1970 |
Multiple transport components for dicarboxylic amino acids in Streptococcus faecalis.
Topics: Amino Acids; Aminoisobutyric Acids; Asparagine; Aspartic Acid; Biological Transport; Carbon Isotopes; Cyclopentanes; Diffusion; Enterococcus faecalis; Glucose; Glutamates; Glutamine; Kinetics | 1970 |
Characterization and chemical modifications of toxins isolated from the venoms of the sea snake, Laticauda semifasciata, from Philippines.
Topics: Amino Acids; Animals; Antigens; Arginine; Asparagine; Aspartic Acid; Chromatography, Gel; Chromatography, Ion Exchange; Crystallization; Electrophoresis; Hot Temperature; Hydrogen-Ion Concentration; Immune Sera; Immunodiffusion; Isoelectric Focusing; Lethal Dose 50; Lysine; Mice; Molecular Weight; Pyrrolidinones; Rabbits; Snakes; Sulfhydryl Compounds; Toxins, Biological; Tryptophan; Ultracentrifugation; Venoms | 1971 |
[Studies of protein bodies and lipids in liver cells of mice injected intraperitoneally with aspartic acid or asparagine].
Topics: Animals; Asparagine; Aspartic Acid; Injections, Intraperitoneal; Lipids; Liver; Male; Mice; Proteins | 1971 |
L-asparaginase from Erwinia carotovora. Substrate specificity and enzymatic properties.
Topics: Alanine; Amides; Amino Acids; Ammonia; Asparaginase; Asparagine; Aspartic Acid; Binding Sites; Dipeptides; Drug Stability; Erwinia; Glycine; Hydrogen-Ion Concentration; Hydroxamic Acids; Insulin; Kinetics; Ovalbumin; Oxygen Isotopes; Peptides; Spectrophotometry; Stereoisomerism; Structure-Activity Relationship; Succinates | 1972 |
Insolubilization of L-asparaginase by covalent attachment to nylon tubing.
Topics: Aldehydes; Asparaginase; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Drug Stability; Hot Temperature; Humans; Hydrogen-Ion Concentration; Kinetics; Leukemia, Lymphoid; Methods; Nylons; Solubility | 1972 |
On the relation of glutamic acid and some allied compounds to corticl spreading depression.
Topics: Action Potentials; Animals; Asparagine; Aspartic Acid; Cerebral Cortex; Cortical Spreading Depression; Glutamates; Glutamine; Hippocampus; Iontophoresis; Membrane Potentials; Rabbits; Rats | 1972 |
Concentration gradients of amino acids between the uterine and blastocoelic fluid in the rabbit.
Topics: Alanine; Amino Acids; Animals; Arginine; Asparagine; Aspartic Acid; Body Fluids; Female; Glutamates; Glycine; Male; Methionine; Methods; Ovum; Pregnancy; Rabbits; Serine; Taurine; Uterus | 1972 |
Partial purification of L-asparaginyl-tRNA synthetase from rabbit liver.
Topics: Acetates; Amino Acyl-tRNA Synthetases; Ammonium Sulfate; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Enzyme Activation; Glucosamine; Glycerol; Liver; Mercaptoethanol; Molecular Weight; Rabbits | 1972 |
Influence of nutrition on the morphology of a strain of Bifidobacterium bifidum.
Topics: Acetates; Alanine; Amino Acids; Asparagine; Aspartic Acid; Culture Media; Cysteine; Glutamates; Lactobacillus; Mutation; Nutritional Physiological Phenomena; Quaternary Ammonium Compounds; Serine; Surface-Active Agents; Tryptophan | 1972 |
Potential inhibitors of L-asparagine biosynthesis. I. -Elimination reactions with -hydroxyaspartic acid derivatives.
Topics: Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Hydroxylation; Stereoisomerism | 1972 |
Oxygen equilibrium characteristics of abnormal hemoglobins. Hirose (alpha-2-beta-2-37Ser), L Ferrara (alpha-2-47-Gly-beta-2), Broussais (alpha-2-90-Asn-beta-2), and Dhofar (alpha-2-beta-2-58Arg).
Topics: Arginine; Asparagine; Aspartic Acid; Electrophoresis, Starch Gel; Genetic Variation; Glycine; Hemoglobins, Abnormal; Heterozygote; Humans; Hydrogen-Ion Concentration; Lysine; Macromolecular Substances; Mathematics; Oxygen; Partial Pressure; Polarography; Proline; Serine; Tryptophan | 1972 |
Requirement of succinate for the growth of Vibrio succinogenes.
Topics: Asparagine; Aspartic Acid; Carbon Isotopes; Cell Fractionation; Chromatography; Culture Media; Formates; Fumarates; Malates; Nitrates; Solvents; Spectrophotometry; Succinates; Trichloroacetic Acid; Vibrio | 1972 |
Replacement of asparagine by aspartic acid in hen ovalbumin and a difference in immunochemical reactivity.
Topics: Amino Acid Sequence; Amino Acids; Animals; Antigens; Asparagine; Aspartic Acid; Chickens; Chymotrypsin; Egg Yolk; Electrophoresis, Starch Gel; Female; Genetic Variation; Immune Sera; Ovalbumin; Peptides; Trypsin | 1972 |
Glutamine-dependent asparagine synthetase from leukemia cells. Chloride dependence, mechanism of action, and inhibition.
Topics: Amino Acids; Ammonium Sulfate; Animals; Asparagine; Aspartic Acid; Bromides; Carbon Isotopes; Catalysis; Chemical Precipitation; Chlorides; Chromatography, Gel; Electrophoresis, Disc; Enzyme Activation; Glutamine; Iodides; Keto Acids; Leukemia, Experimental; Ligases; Mice; Phosphorus Isotopes; Protein Binding; Quaternary Ammonium Compounds | 1972 |
Effects of L-asparaginase on lymphocyte surface and blastogenesis.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Binding Sites; Cell Membrane; Cell Survival; Cells, Cultured; Concanavalin A; DNA; Dose-Response Relationship, Drug; Glutamine; Immunity; Immunosuppressive Agents; Iodine Isotopes; Isoelectric Focusing; Lymphocyte Activation; Lymphocytes; Mitosis; Protein Binding; Rats; Receptors, Drug; Time Factors | 1972 |
Studies on the dansylation reaction by the use of 14 C-dansyl chloride: application to analysis of free amino acids in the rat optic nerve.
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; Autoanalysis; Autoradiography; Carbon Isotopes; Chemical Phenomena; Chemistry; Chlorine; Chromatography, Thin Layer; Dansyl Compounds; Glucose; Glutamates; Glutamine; Glycine; Male; Methods; Optic Nerve; Rats; Tritium | 1972 |
Hemoglobin J Singapore: alpha 78 Asn--Asp; alpha 79 Ala--Gly.
Topics: Adult; Alanine; Amino Acid Sequence; Amino Acids; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Paper; Electrophoresis, Paper; Ethnicity; Female; Glycine; Hemoglobinopathies; Hemoglobins; Hemoglobins, Abnormal; Humans; Male; Molecular Biology; Peptides; Singapore; Spectrophotometry; Thermolysin; Trypsin | 1972 |
Effect of magnesium chelators on the regulation of pyruvate oxidation by rabbit heart mitochondria.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Asparagine; Aspartic Acid; Barbiturates; Chelating Agents; Depression, Chemical; Heart; Magnesium; Mitochondria, Muscle; Myocardium; Nitriles; Oxygen Consumption; Phenanthrolines; Phenylhydrazines; Pyridines; Pyruvates; Rabbits; Structure-Activity Relationship; Uncoupling Agents | 1972 |
The effect of L-asparaginase in mixed leukocyte culture.
Topics: Asparaginase; Asparagine; Aspartic Acid; Culture Techniques; Depression, Chemical; Glutamine; Humans; Leukocytes; Thymidine; Tritium | 1971 |
Transamination of amino acids in homogenates of rat brzain.
Topics: Age Factors; Alanine; Amino Acids; Animals; Animals, Newborn; Asparagine; Aspartic Acid; Brain; Chromatography; Culture Media; Electrophoresis, Paper; Glutamates; Glutamine; Isoleucine; Ketoglutaric Acids; Male; Methionine; Organ Culture Techniques; Ornithine; Phenylalanine; Pyruvates; Rats; Transaminases; Tryptophan; Tyrosine; Valine | 1971 |
Haemoglobin Osu-Christiansborg: a new beta-chain variant of haemoglobin A ( beta52 (D3) aspartic acid leads to asparagine) in combination with haemoglobin S.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Blood Protein Electrophoresis; Electrophoresis, Disc; Ghana; Hemoglobins, Abnormal; Heterozygote; Humans; Male; Middle Aged; Mutation; Pedigree | 1971 |
Aspartic acid, asparagine, glutamic acid, and glutamine contents of wool and two derived protein fractions.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Glutamates; Insulin; Methods; Proteins; Ribonucleases; Sheep; Wool | 1971 |
Inhibition of murine tumors by carbobenzoxy derivatives of amino acids.
Topics: Amino Acids; Animals; Antineoplastic Agents; Asparagine; Aspartic Acid; Benzyl Compounds; Carcinoma, Ehrlich Tumor; Cysteine; Formates; Lymphoma, Non-Hodgkin; Mammary Neoplasms, Experimental; Mice; Neoplasms, Experimental; Phenylalanine | 1971 |
Active transport of glutamate in Streptomyces hydrogenans. I. Studies on uptake and pool size, and their interrelationship.
Topics: Aminoisobutyric Acids; Arginine; Asparagine; Aspartic Acid; Biological Transport, Active; Carbon Isotopes; Chromatography, Paper; Cold Temperature; Culture Media; Dinitrophenols; Glutamate Dehydrogenase; Glutamates; Glutamine; Glycine; Histidine; Hydrogen-Ion Concentration; Kinetics; Leucine; Lysine; Mathematics; Methionine; Osmosis; Phenylalanine; Protein Biosynthesis; Stereoisomerism; Streptomyces; Temperature; Tyrosine | 1971 |
Studies on fruit tissues of Citrus acida. I. Utilization of protein for the respiration in mature fruit tissues of Citrus acida.
Topics: Adenosine Triphosphate; Alanine; Alanine Transaminase; Amides; Aminobutyrates; Ammonia; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Carboxy-Lyases; Citrus; Glutamate Dehydrogenase; Glutamates; Glutamine; Ligases; Oxygen Consumption; Peptide Hydrolases; Plant Development; Plant Proteins; Plants; Time Factors | 1971 |
Hepatic homeostasis of plasma L-asparagine.
Topics: Animals; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Boron Compounds; Citric Acid Cycle; Depression, Chemical; Fluoroacetates; Homeostasis; In Vitro Techniques; Liver; Male; Perfusion; Rats; Stereoisomerism | 1971 |
Molecular orbital calculations on the conformation of polypeptides and proteins. 8. The conformational energy maps and stereochemical rotational states of the asparaginyl, glutaminyl aspartyl and glutamyl residues.
Topics: Amides; Amino Acids; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Glutamates; Glutamine; Mathematics; Molecular Weight; Peptides; Protein Conformation; Quantum Theory | 1971 |
Activity and regulation of an acidic amino acid permease of Aspergillus nidulans.
Topics: Ammonia; Asparagine; Aspartic Acid; Aspergillus; Cycloheximide; Cysteine; Glutamates; Glycine; Kinetics; Lysine; Membrane Transport Modulators; Membrane Transport Proteins; Methylamines; Nitrates; Urea | 1971 |
The acid hydrolysis of 2-acetamido-1-N-(4-L-aspartyl)-2-deoxy- -D-glucopyranosylamine.
Topics: Acetates; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Glucosamine; Glycosides; Hexosamines; Hydrogen-Ion Concentration; Hydrolysis; Pyrans; Stereoisomerism; Time Factors | 1971 |
Synthesis of highly deuterated amino acids.
Topics: Amino Acids; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Deuterium; Eukaryota; Glutamates; Oxytocin; Phenylalanine; Pigments, Biological; Vasopressins | 1966 |
The influence of short-range interactions on protein conformation. I. Side chain-backbone interactions within a single peptide unit.
Topics: Alanine; Amino Acid Sequence; Arginine; Asparagine; Aspartic Acid; Binding Sites; Cystine; Glutamates; Glutamine; Glycine; Histidine; Isoleucine; Kinetics; Leucine; Lysine; Methionine; Muramidase; Phenylalanine; Proline; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1968 |
Serine requirement in leukemic and normal blood cells.
Topics: Alanine; Asparagine; Aspartic Acid; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Culture Media; DNA, Neoplasm; Fibroblasts; Glucose; Glutamates; Glycine; Humans; In Vitro Techniques; Leukemia, Myeloid; Neoplasm Proteins; Proline; RNA, Neoplasm; Serine; Thymidine; Tritium; Uridine | 1969 |
[Further studies on the deamination of amino acids by Streptococcus mitis. 2. Deamination of asparagine].
Topics: Amidohydrolases; Amino Acids; Ammonia; Asparagine; Aspartic Acid; Dental Caries; Streptococcus | 1969 |
Asparagine metabolism in some lymphoproliferative disorders.
Topics: Adult; Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Blood Proteins; Carbon Dioxide; Carbon Isotopes; Child; Child, Preschool; Glutamates; Humans; Leukemia, Lymphoid; Lipids; Lymphocytes; Lymphoma, Non-Hodgkin | 1970 |
Diminished oxidation of 14C-UL-L-asparagine to 14CO2 in mice and humans with tumors: a possible means for assessing efficacy of therapy?
Topics: Animals; Asparagine; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Humans; Injections, Intravenous; Leukemia, Lymphoid; Male; Mice; Multiple Myeloma; Neoplasms; Neoplasms, Experimental; Oxidation-Reduction | 1970 |
Hemoglobin Yoshizuka (G10(108)beta asparagine--aspartic acid): a new variant with a reduced oxygen affinity from a Japanese family.
Topics: Amino Acids; Asparagine; Aspartic Acid; Chromatography; Consanguinity; Electrophoresis; Hemoglobins, Abnormal; Humans; Japan; Male; Middle Aged; Oxygen Consumption; Racial Groups; Spectrophotometry | 1969 |
Suppression of Rauscher virus-induced leukemia by L-asparaginase.
Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Blood; Leukemia, Experimental; Mice; Organ Size; Rauscher Virus; Splenomegaly | 1969 |
[Asparagine and aspartic acid in the blood in malignant and benign diseases].
Topics: Adult; Aged; Asparagine; Aspartic Acid; Bronchial Neoplasms; Cholecystitis; Female; Gastrointestinal Diseases; Gastrointestinal Neoplasms; Hernia; Humans; Male; Middle Aged; Pancreatitis; Sigmoid Neoplasms; Stomach Ulcer | 1969 |
Some properties of a lipase from Rhizopus arrhizus. Separation of a glycopeptide bound to the enzyme.
Topics: Amino Acids; Asparagine; Aspartic Acid; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Drug Stability; Glycoproteins; Hexosamines; Lipase; Mannose; Molecular Weight; Peptides; Proteins; Rhizopus; Spectrum Analysis; Temperature; Trichloroacetic Acid | 1969 |
[Enzyme induction and metabolic regulation in mycobacteria. II. Utilization of glutamic acid and propionic acid in the proliferative phase of M. smegmatis].
Topics: Alanine; Amides; Amino Acids; Aminobutyrates; Asparagine; Aspartic Acid; Chromatography, Paper; Culture Media; Enzyme Induction; Enzyme Repression; Formamides; Glutamates; Glutamine; Glycerol; Mycobacterium; Oxygen Consumption; Propionates; Valine | 1969 |
The nature of a hydroxylamine-sensitive bond in collagen.
Topics: Animals; Asparagine; Aspartic Acid; Bromine; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Collagen; Colorimetry; Cyanides; Hydroxylamines; Imides; Methods; Molecular Weight; Peptides; Rats; Skin; Tendons; Trypsin | 1969 |
[The problems of "fatigue" in the light of the most recent advances in biochemistry].
Topics: Adenine Nucleotides; Animals; Asparagine; Aspartic Acid; Fatigue; Humans; Magnesium; Muscles; Potassium | 1970 |
The labeling of dicarboxylic amino acids and their amides by glucose and acetate in human platelets.
Topics: Amino Acids; Asparagine; Aspartic Acid; Biological Assay; Blood Platelets; Carbon Isotopes; Glutamates; Glutamine; Humans; Radiometry; Uranium | 1970 |
The importance of dispensable amino acids for maximal growth in the rat.
Topics: Alanine; Amino Acids; Animals; Arginine; Asparagine; Aspartic Acid; Body Weight; Citrates; Diet; Glutamates; Glycine; Growth; Male; Nutritional Requirements; Proline; Rats; Serine | 1970 |
Subunit structure of dipeptidyl transferase.
Topics: Asparagine; Aspartic Acid; Benzoates; Chlorides; Chromatography, Gel; Detergents; Dipeptides; Electrophoresis; Endopeptidases; Ethylmaleimide; Guanidines; Hydrogen-Ion Concentration; Molecular Weight; Spleen; Sulfhydryl Compounds; Sulfuric Acids; Ultracentrifugation; Urea | 1970 |
Modification of carboxyl groups in the active site of trypsin.
Topics: Amides; Animals; Asparagine; Aspartic Acid; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Glycine; Hydantoins; Imides; Trypsin; Trypsin Inhibitors | 1970 |
[The occurrence of L-asparaginase in mycobacteria].
Topics: Ammonia; Asparaginase; Asparagine; Aspartic Acid; Culture Media; Glycerol; Isoniazid; Mycobacterium; Species Specificity; Stereoisomerism; Streptomycin; Sulfates | 1970 |
The amino acid sequence of T4 phage lysozyme. IV. Dilute acid hydrolysis and the order of tryptic peptides.
Topics: Amino Acid Sequence; Amino Acids; Asparagine; Aspartic Acid; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Coliphages; Electrophoresis; Glutamates; Hot Temperature; Hydrogen-Ion Concentration; Leucine; Muramidase; Peptides; Trypsin; Valine | 1970 |
Primary structure of two COOH-terminal hexapeptides from rabbit muscle aldolase: a difference in the structure of the alpha and beta subunits.
Topics: Amino Acid Sequence; Amino Acids; Animals; Asparagine; Aspartic Acid; Carboxypeptidases; Chromatography, Ion Exchange; Chymotrypsin; Fructose-Bisphosphate Aldolase; Histidine; Muscles; Rabbits; Trypsin; Tyrosine | 1970 |
Protein-bound amide groups in brain.
Topics: Amides; Ammonia; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Cerebral Cortex; Glucose; Glutamates; Glutamine; Hydrochloric Acid; Nerve Tissue Proteins; Pentobarbital; Peptide Hydrolases; Picrotoxin; Protein Binding; Rats; Seizures; Streptomyces | 1970 |
Acid protease from germinated sorghum. 2. Substrate specificity with synthetic peptides and ribonuclease A.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Endopeptidases; Formates; Glutamates; Glutamine; Methylation; Peptides; Peroxides; Plants; Ribonucleases | 1970 |
The covalent structure of a human gamma G-immunoglobulin. VI. Amino acid sequence of the light chain.
Topics: Amino Acid Sequence; Amino Acids; Arginine; Asparagine; Aspartic Acid; Bence Jones Protein; Chromatography; Chromatography, Ion Exchange; Chymotrypsin; Glycine; Humans; Immunoglobulin G; Immunoglobulins; Sulfonic Acids; Trypsin | 1970 |
[Effect of amino acids on the growth of Streptococcus lactis and biosynthesis of nisin].
Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Arginine; Asparagine; Aspartic Acid; Culture Media; Cysteine; Cystine; Depression, Chemical; Glutamates; Glycine; Histidine; Leucine; Lysine; Methionine; Ornithine; Phenylalanine; Proline; Serine; Stimulation, Chemical; Streptococcus; Threonine; Tryptophan; Valine | 1970 |
The distribution of asparaginase activity in legumes.
Topics: Asparaginase; Asparagine; Aspartic Acid; Carbon Isotopes; Nitrogen Fixation; Plants; Rhizobium | 1970 |
Benzyl and p-nitrobenzyl monoesters of N-t-butyloxycarbonyl-L-glutamic acid and N-t-butyloxycarbonyl-L-aspartic acid.
Topics: Amines; Asparagine; Aspartic Acid; Cyclohexanes; Dimethylformamide; Esters; Furans; Glutamates; Glutamine; Nitrobenzenes | 1970 |
Asparagine biosynthesis in human KB tumor cells: inhibitor studies with asparagine and glutamine antagonists.
Topics: Amino Acids; Anti-Bacterial Agents; Asparagine; Aspartic Acid; Azaserine; Azo Compounds; Carcinoma; Cell Line; Culture Techniques; Glutamine; Humans; Ligases; Mouth Neoplasms; Puromycin | 1970 |
Optical rotatory dispersion of 1-N-beta-L-aspartyl-2-acetamido-2-deoxy-beta-D-glucopyranosylamine.
Topics: Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Glucosamine; Glycoproteins; Optical Rotatory Dispersion; Stereoisomerism | 1970 |
Chemical characterization of cytochrome P-450cam.
Topics: Amino Acid Sequence; Amino Acids; Asparagine; Aspartic Acid; Autoanalysis; Camphor; Carbohydrates; Carboxypeptidases; Chemical Phenomena; Chemistry; Cytochromes; Formates; Heme; Hydrazines; Hydrogen-Ion Concentration; Isoelectric Focusing; Isoflurophate; Molecular Weight; Nitrobenzenes; Peptides; Porphyrins; Pseudomonas; Valine | 1970 |
L-asparaginase: early findings and current studies on the metabolism of L-asparagine in lymphoma cells.
Topics: Amino Acyl-tRNA Synthetases; Asparaginase; Asparagine; Aspartic Acid; Cell Line; Chromatography, DEAE-Cellulose; Drug Resistance; Kinetics; Leucine; Lymphoma; Neoplasm Proteins; Neoplasms, Experimental; RNA, Transfer | 1970 |
With reference to blastogenesis inhibition by L-asparaginase.
Topics: Asparaginase; Asparagine; Aspartic Acid; Cells, Cultured; Depression, Chemical; Glutamine; Humans; Lectins; Lymphocyte Activation; Time Factors | 1970 |
Asparagine incorporation into the DNA of hepatic and 6C3HED murine lymphosarcoma cells.
Topics: Amino Acids; Aminohydrolases; Animals; Asparagine; Aspartic Acid; Carbon Isotopes; DNA; DNA, Neoplasm; Liver; Lymphoma, Non-Hodgkin; Male; Mice; Neoplasms, Experimental | 1970 |
Evaluation of L-asparagine metabolism in animals and man.
Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Dogs; Erythrocytes; Fluorometry; Hepatectomy; Humans; Hypophysectomy; Leukemia, Experimental; Lymphoma; Lymphoma, Non-Hodgkin; Methods; Mice; Neoplasms, Experimental; Rats; Renal Dialysis; Spectrophotometry | 1970 |
L-asparaginase II of Escherichia coli. Studies on the enzymatic mechanism of action.
Topics: Asparaginase; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Colorimetry | 1971 |
Human amyloid protein: chemical variability and homogeneity.
Topics: Adult; Aged; Amino Acids; Amyloid; Amyloidosis; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Chromatography, Gel; Dicarboxylic Acids; Electrophoresis, Disc; Female; Guanidines; Humans; Hydroxyproline; Immunoglobulins; Liver; Male; Microscopy, Electron; Middle Aged; Molecular Weight; Peptides; Spleen; Trypsin; Tryptophan; X-Ray Diffraction | 1971 |
Metabolism of asparagine, aspartate, glutamine, and glutamate in lymphoid tissue: basis for immunosuppression by L-asparaginase.
Topics: Amino Acids; Animals; Asparaginase; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Carbon Isotopes; Dogs; Glutamates; Glutamine; Humans; Immunity; Immunosuppression Therapy; Ligases; Lymph Nodes; Lymphoid Tissue; Mice; Spleen | 1971 |
Purification and chemical studies of a toxin from the venom of Lapemis hardwickii (Hardwick's sea snake).
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Chromatography, Gel; Chromatography, Ion Exchange; Crystallization; Electrophoresis; Histidine; Hydrogen-Ion Concentration; Isoelectric Focusing; Mice; Molecular Weight; Nitrobenzenes; Pyrrolidinones; Snakes; Spectrum Analysis; Sulfenic Acids; Sulfhydryl Compounds; Toxins, Biological; Tryptophan; Ultracentrifugation; Venoms | 1971 |
Tritium--hydrogen exchange of bacitracin A. Evidence for an intramolecular hydrogen bond.
Topics: Asparagine; Aspartic Acid; Bacitracin; Chemical Phenomena; Chemistry; Chromatography, Gel; Histones; Hydrogen; Hydrogen-Ion Concentration; Kinetics; Membranes, Artificial; Oxidation-Reduction; Temperature; Time Factors; Tritium | 1971 |
Glutamyl, aspartyl and amide moieties of cerebral proteins: metabolic aspects in vitro.
Topics: Amides; Ammonia; Ammonium Chloride; Animals; Asparaginase; Asparagine; Aspartic Acid; Autoradiography; Carbon Isotopes; Carboxy-Lyases; Cats; Cerebral Cortex; Glutamates; Glutaminase; Glutamine; Hydrolases; Hydrolysis; In Vitro Techniques; Mass Spectrometry; Nerve Tissue Proteins; Nitrogen Isotopes; Protein Binding | 1971 |
Energy metabolism of proteins and amino acids.
Topics: Alanine; Amino Acids; Animals; Arginine; Asparagine; Aspartic Acid; Body Temperature Regulation; Caseins; Dietary Proteins; Gelatin; Glutamates; Glycine; Humans; Leucine; Muscles; Nutritional Physiological Phenomena; Proteins; Rats; Tyrosine | 1971 |
Solic phase synthetic study of the active site region of staphylococcal nuclease-T'.
Topics: Amides; Amino Acid Sequence; Arginine; Asparagine; Aspartic Acid; Binding Sites; Calcium; Chemical Phenomena; Chemistry; Chromatography, Paper; Citrulline; Deoxyribonucleases; Electrophoresis; Fluorescence; Glutamates; Lysine; Models, Structural; Peptides; Protein Binding; Ribonucleases; Spectrum Analysis; Staphylococcus; Trypsin | 1971 |
Ammonia production by rumen microbes in vitro.
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Asparagine; Aspartic Acid; Cysteine; Glutamates; Glutamine; Glycine; Histidine; Hydrogen-Ion Concentration; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Rumen; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1967 |
Studies on progressive muscular dystrophy. IV. Effects of original amino acids mixture on progressive muscular dystrophy.
Topics: Adenosine Triphosphate; Adolescent; Adult; Amino Acids; Arginine; Asparagine; Aspartic Acid; Blood Proteins; Child; Deficiency Diseases; Glutamates; Glycine; Histidine; Humans; Isoleucine; Leucine; Lysine; Male; Methionine; Muscles; Muscular Dystrophies; Phenylalanine; Threonine; Tryptophan; Tyrosine; Valine | 1967 |
Configuration of the asparaginyl and aspartyl residues of bacitracin.
Topics: Amino Acids; Asparagine; Aspartic Acid; Bacitracin; Chemical Phenomena; Chemistry; Peptides | 1968 |
The effects of L-asparaginase on the amino acid incorporation of mouse lymphoid tumors.
Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Carbon Isotopes; Leucine; Lymphoma; Mice; Neoplasms, Experimental; Tritium | 1968 |
Studies on asparagine synthesis and utilization in seedlings.
Topics: Amino Acids; Asparagine; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Cyanides; Edible Grain; Pyruvates | 1968 |
High-resolution nuclear magnetic resonance spectra of selectively deuterated staphylococcal nuclease.
Topics: Amino Acids; Asparagine; Aspartic Acid; Calcium; Deoxyribonucleases; Deuterium; Glutamates; Glutamine; Histidine; Magnetic Resonance Spectroscopy; Methionine; Nucleotides; Ribonucleases; Staphylococcus; Tryptophan; Tyrosine | 1968 |
[On the question of biosynthesis of 2 acetyl-2 decarboxamidooxytetracycline by the culture Act. rimosus].
Topics: Actinomyces; Ammonia; Asparagine; Aspartic Acid; Culture Media; Glutamates; Glutamine; Oxytetracycline; Streptomyces; Sulfates; Time Factors; Urea | 1968 |
Threo- and erythro-beta-hydroxyl-l-asparagines.
Topics: Amides; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry | 1968 |
[The effects of L-asparaginase and an analogue of asparagine, L-2-amino-2-carboxyethanesulfonamide, on the development of the sea urchin egg].
Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Echinodermata; Female; Ovum | 1968 |
Incorporation of serine-U-14C into beta-cyanoalanine and gamma-glutamyl-beta-cyanoalanine in Vicia sativa.
Topics: Alanine; Amino Acids; Asparagine; Aspartic Acid; Glutamates; Nitriles; Peptide Biosynthesis; Plant Development; Plants; Seeds; Serine | 1968 |
Naturally occurring low-molecular-weight peptides from the blowfly Phormia regina.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Dipeptides; Diptera; Glutamine; Glycine; Isoleucine; Lysine; Peptides; Serine; Valine | 1968 |
Haemoglobin Korle-Bu (beta 73 aspartic acid replaced by asparagine) showing one of the two amino acid substitutions of haemoglobin C Harlem.
Topics: Aged; Amino Acid Sequence; Amino Acids; Anemia, Sickle Cell; Asparagine; Aspartic Acid; Crossing Over, Genetic; Electrophoresis; Hemoglobins, Abnormal; Humans; Male | 1968 |
[Crystalline leucine aminopeptidase from bovine lens. Amino acid composition and N-terminal amino acids, II].
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; Cattle; Crystallography; Formates; Glutamates; Glutamine; Glycine; Lens, Crystalline; Leucine; Leucyl Aminopeptidase; Lysine; Serine; Threonine | 1968 |
Uptake of asparagine C-14 into the pyrimidine synthesis pathway of guinea pig serum sensitive 6C3HED lymphosarcoma cells.
Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; Carbon Isotopes; Culture Techniques; DNA, Neoplasm; Guinea Pigs; Lymphoma, Non-Hodgkin; Male; Mice; Neoplasms, Experimental; Pyrimidines | 1968 |
Beta-cyanoalanine formation by Chromobacterium violaceum.
Topics: Alanine; Amino Acids; Asparagine; Aspartic Acid; Carbon Isotopes; Chromobacterium; Cyanides; Formaldehyde; Glycine; Methionine; Serine; Succinates | 1969 |
Studies on the aspartic acid "sparing effect" on the nutritional requirement of L-asparagine for tumors in vitro.
Topics: Animals; Asparagine; Aspartic Acid; Carcinoma 256, Walker; Culture Techniques; Enzyme Induction; Female; Ligases; Rats; Sarcoma, Experimental | 1969 |
Human platelets: amino acid synthesis.
Topics: Acetates; Asparagine; Aspartic Acid; Blood Platelets; Carbon Isotopes; Citric Acid Cycle; Coenzyme A; Glucose; Glutamates; Glutamine; Humans | 1969 |
Metabolic traits in mentally retarded children as compared with normal populations: monoaminodicarboxylic acids and their half amides and total amino acids.
Topics: Adolescent; Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Child; Child, Preschool; Chromatography; Chromatography, Paper; Female; Glutamates; Glutamine; Glycine; Humans; Intellectual Disability; Male | 1969 |
Asparagine synthetase from gamma-irradiated potatoes.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Asparagine; Aspartic Acid; Carbon Isotopes; Chemical Precipitation; Chromatography, Gel; Food Irradiation; Hydrogen-Ion Concentration; Hydroxylamines; Kinetics; Ligases; Magnesium; Manganese; Methods; Phosphates; Plants; Quaternary Ammonium Compounds; Radiation Effects; Transferases; Vegetables | 1969 |
Free amino acids of normal and abnormal human placenta.
Topics: Amino Acids; Arginine; Asparagine; Aspartic Acid; Biological Transport, Active; Female; Glutamine; Humans; Hydatidiform Mole; Infarction; Ligases; Placenta; Placenta Diseases; Pre-Eclampsia; Pregnancy; Pregnancy Complications | 1969 |
Total optical resolution of free alpha-amino-acids by the inoculation method.
Topics: Asparagine; Aspartic Acid; Crystallization; Glutamates; Glutamine | 1965 |
Nutritional studies of Histoplasma capsulatum.
Topics: Asparagine; Aspartic Acid; Culture Media; Cysteine; Cystine; Glutamates; Glutathione; Histoplasma; Methionine; Proline; Thioglycolates; Vitamins | 1965 |
Dietary requirement for asparagine and its metabolism in rats.
Topics: Animals; Asparagine; Aspartic Acid; Carbon Dioxide; Caseins; Diet; Glutamine; Protein Hydrolysates; Rats | 1966 |
Cyanoacetylene in prebiotic synthesis.
Topics: Alkynes; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Cyanides; Cytosine | 1966 |
Kinetic studies on the action of carboxypeptidase A on bovine insulin and related model peptides.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Carboxypeptidases; Cattle; Chemical Phenomena; Chemistry; Glutamates; Glutamine; Hydrogen-Ion Concentration; In Vitro Techniques; Insulin; Kinetics; Models, Theoretical; Peptides; Spectrophotometry | 1966 |
The effects of salicylate on guinea-pig testis mitochondria compared with the effects of aging and repeated washing.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Citrates; Fumarates; Glutamates; Guinea Pigs; In Vitro Techniques; Ketoglutaric Acids; Lactates; Malates; Male; Mitochondria; Salicylates; Succinates; Testis | 1966 |
The reactive site of trypsin inhibitors.
Topics: Asparagine; Aspartic Acid; Carboxypeptidases; Catalysis; Chemical Phenomena; Chemistry; Chromatography; Glycine max; Trypsin Inhibitors | 1966 |
[Two dimension chromatography of ether soluble dinitrophenyl-amino acids and chromato-electrophoresis of hydracid-soluble DNP-amino acids on thin layers of powdered cellulose].
Topics: Arginine; Asparagine; Aspartic Acid; Cellulose; Chromatography, Thin Layer; Cysteine; Dinitrophenols; Electrophoresis; Glutamates; Glutamine; Histidine; Lysine | 1966 |
Water relations of Salmonella oranienburg; stimulation of respiration by amino acids.
Topics: Alanine; Asparagine; Aspartic Acid; Carbon Isotopes; Culture Media; Cysteine; Glucose; Glutamine; Glycine; Methionine; Oxygen Consumption; Proline; Salmonella; Serine; Threonine; Water | 1966 |
Photochemical synthesis of amino acids from paraformaldehyde catalyzed by inorganic agents.
Topics: Alanine; Amino Acids; Asparagine; Aspartic Acid; Catalysis; Chemistry, Organic; Chromatography, Paper; Cobalt; Copper; Formaldehyde; Iron; Leucine; Light; Lysine; Nitrates; Organic Chemistry Phenomena; Quaternary Ammonium Compounds; Sulfides; Valine | 1966 |
The conversion of [3H]tyrosine to [3H]DOPA in mouse melanoma in vivo.
Topics: Animals; Asparagine; Aspartic Acid; Chromatography, Paper; Dihydroxyphenylalanine; Electrophoresis; Glutamates; Glutamine; Melanoma; Mice; Neoplasms, Experimental; Tyrosine | 1966 |
Biosynthesis of 2,4-diaminobutyric acid from L-[3H]homoserine and DL-[1-14C]aspartic acid in Lathyrus sylvestris W.
Topics: Amino Acids; Aminobutyrates; Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography, Paper; In Vitro Techniques; Plants; Threonine | 1966 |
Amino acids and the maintenance of osmotic equilibrium in brain tissue.
Topics: Alanine; Amino Acids; Amino Alcohols; Aminobutyrates; Animals; Anura; Asparagine; Aspartic Acid; Brain Chemistry; Female; Glutamates; Glutamine; Glycine; Male; Osmosis; Urea | 1966 |
Deuterated amino acids. 3. Synthesis of DL-Aspartic-2,3,3-d-3 acid, L-glutamic-2,3,3,4,4-d-5 acid, L-asparagine-2,3,3-d-3, and L-Glutamine-2,3,3,4,4-d-5 1,2a.
Topics: Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Chemistry, Organic; Deuterium; Glutamates; Glutamine; Organic Chemistry Phenomena | 1966 |
[The influence of temperature on the content of some carbohydrates and amino acids in Spirogyra].
Topics: Alanine; Amino Acids; Aminobutyrates; Asparagine; Aspartic Acid; Carbohydrate Metabolism; Chromatography, Paper; Eukaryota; Fructose; Glucose; Glutamates; Glutamine; Leucine; Nitrogen; Serine; Starch; Temperature; Valine | 1966 |
Identification of an antigenic determinant of collagen treated with hydroxylamine.
Topics: Agglutination; Animals; Antigen-Antibody Reactions; Asparagine; Aspartic Acid; Cattle; Chemical Phenomena; Chemistry; Collagen; Glycine; Hemagglutination Inhibition Tests; Hemagglutination Tests; Hydroxamic Acids; Hydroxylamines; Immune Sera; Rabbits | 1967 |
Amino acid substitution of hemoglobin Ube 2 (alpha-2 68asp beta-2): an example of successful application of partial hydrolysis of peptide with 5 per cent acetic acid.
Topics: Acetates; Amino Acids; Asparagine; Aspartic Acid; Blood Protein Electrophoresis; Chemistry, Clinical; Hemoglobins, Abnormal; Humans; Peptides; Trypsin | 1967 |
The influence of medium composition on the growth and swarming of Proteus.
Topics: Alanine; Asparagine; Aspartic Acid; Culture Media; Glutamates; Glutamine; Proline; Proteus; Serine | 1967 |
Brain amino acid uptake: the effect of L-aspartic acid, L-N-acetyl aspartic acid, and L-asparagine administration in the rat.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Blood-Brain Barrier; Brain Chemistry; Centrifugation; Chromatography, Paper; Male; Rats | 1967 |
Urinary amino acids of rats receiving high sugar diets.
Topics: Alanine; Alcohols; Amino Acids; Animals; Arabinose; Ascorbic Acid; Asparagine; Aspartic Acid; Dietary Carbohydrates; Female; Galactose; Glucose; Glutamates; Glycine; Inositol; Intestines; Neomycin; Rats; Ribose; Serine; Taurine; Threonine; Xylitol; Xylose | 1967 |
Effects of L-asparagine and related compounds on the hepatic fatty infiltration and necrosis induced by ethionine and carbon tetrachloride.
Topics: Animals; Asparagine; Aspartic Acid; Carbon Tetrachloride; Chromatography, Gas; Ethionine; Fatty Acids; Fatty Liver; Female; Glutamine; Glycerides; Ketoglutaric Acids; Liver; Methionine; Necrosis; Rats; Triglycerides | 1967 |
Haemoglobin G Copenhagen and haemoglobin J Cambridge. Two new beta-chain variants of haemoglobin A.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Blood Protein Electrophoresis; Chymotrypsin; Denmark; Glycine; Hemoglobins, Abnormal; Humans; Leucyl Aminopeptidase; Peptides; Sampling Studies; United Kingdom | 1967 |
Regulation of glutamine synthetase. VI. Interactions of inhibitors for Bacillus licheniformis glutamine synthetase.
Topics: Acyltransferases; Adenine Nucleotides; Alanine; Ammonium Chloride; Asparagine; Aspartic Acid; Bacillus; Carbamates; Drug Antagonism; Drug Synergism; Feedback; Glutamates; Glutamine; Glycine; Histidine; Hydroxamic Acids; Isoleucine; Kinetics; Ligases | 1967 |
Requirements for growth of Streptococcus agalactiae in a chemically defined medium.
Topics: Alanine; Ascorbic Acid; Asparagine; Aspartic Acid; Culture Media; Cysteine; Cystine; Proline; Serine; Streptococcus; Thioglycolates | 1967 |
Intrinsic dissociation constants of aspartyl and glutamyl carboxyl groups.
Topics: Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry, Physical; Glutamates; Glutamine; Hydrogen-Ion Concentration | 1967 |
The influence of nitrogenous compounds on growth of Pythium species.
Topics: Alanine; Amino Acids; Aminobutyrates; Asparagine; Aspartic Acid; Cysteine; Fungi; Glutamates; Glycine; Histidine; Hydrogen-Ion Concentration; Nitrates; Nitrites; Nitrogen; Peptones; Quaternary Ammonium Compounds; Serine; Succinates; Threonine; Yeast, Dried | 1967 |
L-asparagine biosynthesis by nutritional variants of the Jensen sarcoma.
Topics: Adenosine Triphosphate; Ammonium Chloride; Animals; Asparagine; Aspartic Acid; Culture Techniques; Electrophoresis; Glutamine; Ligases; Magnesium; Sarcoma, Experimental | 1967 |
A new assay for L-asparagine synthetase.
Topics: Aluminum; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Carbon Radioisotopes; Decarboxylation; Ligases; Methods; Pyridoxal | 1980 |
Asparagine as precursor for transmitter aspartate in corticostriatal fibres.
Topics: Animals; Asparagine; Aspartic Acid; Carbon Radioisotopes; Corpus Striatum; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Neurotransmitter Agents; Rats | 1980 |
Effect of asparagine, glutamine and insulin on cerebral amino acid neurotransmitters.
Topics: Animals; Asparagine; Aspartic Acid; Brain Chemistry; Cerebellum; Friedreich Ataxia; gamma-Aminobutyric Acid; Glutamates; Glutamine; Insulin; Male; Medulla Oblongata; Neurotransmitter Agents; Rats | 1980 |
Huntington's disease. Glutamate and aspartate metabolism in blood platelets.
Topics: Adult; Asparagine; Aspartic Acid; Blood Platelets; Female; Glutamates; Glutamic Acid; Glutamine; Humans; Huntington Disease; Kinetics; Male; Middle Aged | 1982 |
Release of endogenous and accumulated exogenous amino acids from slices of normal and climbing fibre-deprived rat cerebellar slices.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Cerebellum; Corpus Striatum; Glutamates; Glutamic Acid; Magnesium; Olivary Nucleus; Pyridines; Rats | 1983 |
A high-performance liquid chromatography assay for asparagine synthetase.
Topics: Amino Acids; Animals; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Cattle; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Glutamates; Glutamine; Ligases; o-Phthalaldehyde; Pancreas; Pyridoxal | 1984 |
Regional distribution of glycoasparagine storage material in the brain in aspartylglycosaminuria.
Topics: Acetylglucosamine; Adult; Asparagine; Aspartic Acid; Axonal Transport; Brain; Capillaries; Endothelium; Glucosamine; Glycopeptides; Humans; Lysosomes; Male; Microscopy, Electron; Nerve Fibers, Myelinated; Neurons | 1981 |
Hb F-Marietta or G gamma I 80[EF4] Asp replaced by Asn, observed in a Caucasian baby.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Fetal Hemoglobin; Georgia; Hemoglobins, Abnormal; Humans; White People | 1982 |
Application of high--performance liquid chromatography to abnormal hemoglobin studies. Characterization of hemoglobins D in Ivory Coast and description of a new variant hb Cocody (beta 21 (B3) Asp leads to Asn).
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Cote d'Ivoire; Hemoglobins, Abnormal; Humans; Isoelectric Point; Trypsin | 1981 |
An Asp-Asn substitution in the proteolipid subunit of the ATP-synthase from Escherichia coli leads to a non-functional proton channel.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; ATP Synthetase Complexes; Escherichia coli; Ion Channels; Macromolecular Substances; Multienzyme Complexes; Mutation; Phosphotransferases; Protons; Structure-Activity Relationship | 1982 |
Hb J Daloa (beta 57 (E1) Asn replaced by Asp): a new variant found in Ivory Coast.
Topics: Adult; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cote d'Ivoire; Female; Hemoglobin J; Hemoglobins, Abnormal; Humans | 1982 |
Thin-layer chromatographic determination of L-asparaginase in the presence of human serum.
Topics: Asparaginase; Asparagine; Aspartic Acid; Chromatography, Thin Layer; Escherichia coli; Humans | 1983 |
The stimulus-secretion coupling of amino acid-induced insulin release: metabolism of L-asparagine in pancreatic islets.
Topics: Acetyl Coenzyme A; Animals; Asparaginase; Asparagine; Aspartic Acid; Cytosol; Fatty Acids; Islets of Langerhans; Kinetics; Mitochondria; NAD; NADP; Oxaloacetates; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats | 1984 |
Synthesis of oxaloacetate in Bacillus subtilis mutants lacking the 2-ketoglutarate dehydrogenase enzymatic complex.
Topics: Asparagine; Aspartic Acid; Bacillus subtilis; Chromosome Mapping; Chromosomes, Bacterial; Citric Acid Cycle; Genes, Bacterial; Inositol; Ketoglutarate Dehydrogenase Complex; Ketone Oxidoreductases; Mutation; Oxaloacetates; Succinates; Succinic Acid | 1984 |
Mechanism of autoxidation of hemoglobin Kempsey (beta 99 Asp----Asn).
Topics: Asparagine; Aspartic Acid; Hemoglobins, Abnormal; Humans; Isoelectric Focusing; Kinetics; Mathematics; Methemoglobin; Oxidation-Reduction | 1984 |
Peritoneal ammonia, a possible inhibitor for blood amino acid loss.
Topics: Amino Acids; Ammonia; Animals; Ascitic Fluid; Asparaginase; Asparagine; Aspartic Acid; Biological Transport; Enzymes, Immobilized; Peritoneal Dialysis; Rats; Urea | 1983 |
Effect of diet on the queuosine family of tRNAs of germ-free mice.
Topics: Animals; Anticodon; Asparagine; Aspartic Acid; Codon; Diet; Female; Germ-Free Life; Guanosine; Histidine; Male; Mice; Nucleoside Q; RNA, Transfer; Tyrosine | 1980 |
Transfer RNA genes of Drosophila melanogaster.
Topics: Animals; Arginine; Asparagine; Aspartic Acid; Base Sequence; DNA, Recombinant; Drosophila melanogaster; Escherichia coli; Genes; Microscopy, Electron; Molecular Weight; Nucleic Acid Conformation; Nucleic Acid Hybridization; Plasmids; RNA, Transfer | 1980 |
The localization of tRNA5Asn, tRNAHis, and tRNAAla genes from drosophila melanogaster by in situ hybridization to polytene salivary gland chromosomes.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Chromosome Mapping; DNA; Drosophila melanogaster; Genes; Histidine; Nucleic Acid Hybridization; RNA, Transfer | 1980 |
Effect of non-essential amino acids on fetal rat pancreatic growth and insulin secretion in vitro.
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; Glycine; Insulin; Insulin Secretion; Organ Culture Techniques; Pancreas; Proline; Rats; Rats, Inbred Strains; Serine | 1981 |
Identification of hemoglobin G-Philadelphia (alpha 68 Asn replaced by Lys) and hemoglobin Matsue-Oki (alpha 75 Asp replaced by Asn) in a black infant.
Topics: Adolescent; Adult; Asparagine; Aspartic Acid; Black People; Child; Female; Genetic Carrier Screening; Genetic Variation; Hemoglobins, Abnormal; Humans; Infant; Lysine; Male; Mutation; Pedigree; Peptide Fragments; Thalassemia | 1982 |
Use of immobilized L-asparaginase in acrylic microparticles in an extracorporeal hollow-fiber dialyzer.
Topics: Acrylic Resins; Animals; Asparaginase; Asparagine; Aspartic Acid; Blood; Microspheres; Perfusion; Renal Dialysis; Sheep; Ultrafiltration | 1983 |
A possible mechanism for the anti-ketogenic action of alanine in the rat.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Depression, Chemical; Diabetes Mellitus, Experimental; Insulin; Ketone Bodies; Liver; Male; Rats; Starvation | 1980 |
Effects of L-aspartic acid, L-asparagine and/or L-asparaginase on forced swimming-induced immobility, analgesia, and decrease in rectal temperature in rats.
Topics: Analgesia; Animals; Asparaginase; Asparagine; Aspartic Acid; Body Temperature; Defecation; Imipramine; Movement; Rats; Rats, Inbred Strains; Swimming | 1982 |
Plasma and erythrocyte amino acid levels in normal adult subjects fed a high protein meal with and without added monosodium glutamate.
Topics: Adult; Alanine; Amino Acids; Asparagine; Aspartic Acid; Dietary Proteins; Erythrocytes; Female; Glutamates; Glutamine; Humans; Male; Sodium Glutamate | 1982 |
Modification of carboxylate groups in bovine pancreatic phospholipase A2. Identification of aspartate-49 as Ca2+-binding ligand.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Calcium; Calcium-Binding Proteins; Carboxylic Acids; Cattle; Hydrogen-Ion Concentration; Pancreas; Phospholipases; Phospholipases A; Phospholipases A2 | 1981 |
Hemoglobin G Copenhagen beta 47 (CD6) Asp leads to Asn in a Sicilian family.
Topics: Amino Acids; Asparagine; Aspartic Acid; Female; Hemoglobins; Hemoglobins, Abnormal; Humans; Italy; Male; Peptide Fragments | 1981 |
1H NMR studies on interactions of calcium and magnesium with aspartic acid and asparagine.
Topics: Animals; Asparagine; Aspartic Acid; Binding Sites; Calcium; Humans; Magnesium; Magnetic Resonance Spectroscopy; Models, Biological; Models, Molecular; Molecular Conformation | 1981 |
Identification of residue 103 in hen egg-white lysozyme.
Topics: Amino Acid Sequence; Amino Acids; Animals; Asparagine; Aspartic Acid; Carboxypeptidases; Chickens; Cyanogen Bromide; Egg White; Muramidase; Peptide Fragments; Trypsin | 1981 |
Hemoglobin G Waimanalo [alpha 64 (E13) Asp replaced by Asn] in a Japanese. Hematologic, functional and synthesis studies.
Topics: Asparagine; Aspartic Acid; Hemoglobins, Abnormal; Humans; Macromolecular Substances; Oxyhemoglobins; Peptide Fragments | 1981 |
Hb Ube-2 (alpha 68[e-17]Asn replaced by Asp): the second instance in Japan.
Topics: Adult; Amino Acid Sequence; Asparagine; Aspartic Acid; Electrophoresis, Cellulose Acetate; Female; Gastritis; Hemoglobins, Abnormal; Humans; Oxyhemoglobins | 1981 |
Conversion of alpha-ketobutyrate to alpha-amino-n-butyric acid by isolated rat liver cells: effect of ethanol.
Topics: Aminobutyrates; Animals; Asparagine; Aspartic Acid; Butyrates; Ethanol; Female; Glutamates; Glutamine; In Vitro Techniques; Liver; Rats; Rats, Inbred Strains | 1981 |
Influence of individual amino acids on incorporation of [14C]leucine by rat liver ribosomes.
Topics: Amino Acids; Amino Acids, Essential; Animals; Asparagine; Aspartic Acid; Glutamates; Glutamine; Leucine; Liver; Rats; Ribosomal Proteins; Ribosomes | 1980 |
Potential carcinostatics. 4. Synthesis and biological properties of erythro- and threo-beta-fluoroaspartic acid and erythro-beta-fluoroasparagine.
Topics: Animals; Antineoplastic Agents; Asparagine; Aspartic Acid; Female; Leukemia L5178; Lung Neoplasms; Male; Mice; Models, Molecular; Molecular Conformation; Neoplasms, Experimental | 1980 |
A single amino acid substitution (Asp leads to Asn) in a phosphoglycerate kinase variant (PGK München) associated with enzyme deficiency.
Topics: Amino Acid Sequence; Amino Acids; Asparagine; Aspartic Acid; Erythrocytes; Genetic Variation; Humans; Metabolism, Inborn Errors; Peptides; Phosphoglycerate Kinase | 1980 |
Mechanism of deamidation of haemoglobin providence Asn.
Topics: Amides; Amino Acid Sequence; Asparagine; Aspartic Acid; Hemoglobins, Abnormal | 1980 |
Fate of [G-3H]glutamate and [U-14C]glucose in the rat liver in vivo.
Topics: Animals; Asparagine; Aspartic Acid; Glucose; Glutamates; Glutamine; Glutathione; Kinetics; Liver; Male; Proteins; Rats | 1980 |
Oxygen affinity and stability of hemoglobin Dunn alpha 6(A4)Asp replaced by Asn): use of isoelectric focusing in recognition of a new abnormal hemoglobin.
Topics: Adult; Asparagine; Aspartic Acid; Female; Hemoglobin A; Hemoglobins, Abnormal; Humans; Isoelectric Focusing; Male; Oxygen; Pedigree | 1980 |
N-Acetylglucosamine-asparagine levels in tissues of patients with aspartylglycosaminuria.
Topics: Acetylglucosamine; Adult; Amidohydrolases; Asparagine; Aspartic Acid; Aspartylglucosaminuria; Endocytosis; Female; Glucosamine; Glycoproteins; Humans; Lysosomes; Male; Tissue Distribution | 1980 |
Glutamate, glutamine, aspartate, asparagine, glucose and ketone-body metabolism in chick intestinal brush-border cells.
Topics: Adenine Nucleotides; Amino Acids, Dicarboxylic; Animals; Asparagine; Aspartic Acid; Chickens; Glucose; Glutamates; Glutamine; Glutathione; In Vitro Techniques; Jejunum; Ketone Bodies; Male; Microvilli; Oxygen Consumption; Rats | 1980 |
Trans-dominant inhibitory human immunodeficiency virus type 1 protease monomers prevent protease activation and virion maturation.
Topics: Animals; Asparagine; Aspartic Acid; Binding Sites; Cell Line; Chlorocebus aethiops; DNA, Viral; Gene Expression; HeLa Cells; HIV Protease; HIV-1; Humans; Kinetics; Macromolecular Substances; Point Mutation; Recombinant Proteins; RNA, Viral; Transfection; Virion | 1995 |
Mutagenesis of the conserved aspartic acid 443, glutamic acid 478, asparagine 494, and aspartic acid 498 residues in the ribonuclease H domain of p66/p51 human immunodeficiency virus type I reverse transcriptase. Expression and biochemical analysis.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Conserved Sequence; DNA Mutational Analysis; Enzyme Stability; Escherichia coli; Glutamates; Glutamic Acid; HIV Reverse Transcriptase; HIV-1; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Protein Denaturation; Ribonuclease H; RNA-Directed DNA Polymerase; Structure-Activity Relationship | 1994 |
Characterization of an RNase H deficient mutant of human immunodeficiency virus-1 reverse transcriptase having an aspartate to asparagine change at position 498.
Topics: Asparagine; Aspartic Acid; Base Sequence; DNA-Directed DNA Polymerase; HIV Reverse Transcriptase; HIV-1; Molecular Sequence Data; Ribonuclease H; RNA-Directed DNA Polymerase; Substrate Specificity; Templates, Genetic | 1994 |
Effect of adjacent histidine and cysteine residues on the spontaneous degradation of asparaginyl- and aspartyl-containing peptides.
Topics: Adrenocorticotropic Hormone; Amides; Amino Acid Sequence; Amino Acids; Asparagine; Aspartic Acid; Cysteine; Histidine; Molecular Sequence Data; Oligopeptides; Stereoisomerism | 1995 |
Identification of Asn289 as a ligand binding site in the rat thyrotropin-releasing hormone (THR) receptor as determined by complementary modifications in the ligand and receptor: a new model for THR binding.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Binding Sites; Calcium; Egtazic Acid; Female; Hydrogen Bonding; Kinetics; Ligands; Mutagenesis, Site-Directed; Oocytes; Point Mutation; Rats; Receptors, Thyrotropin-Releasing Hormone; Recombinant Proteins; Restriction Mapping; Thyrotropin-Releasing Hormone; Xenopus laevis | 1995 |
Electrostatic dominoes: long distance propagation of mutational effects in photosynthetic reaction centers of Rhodobacter capsulatus.
Topics: Amino Acid Sequence; Arginine; Asparagine; Aspartic Acid; Electron Transport; Hydrogen-Ion Concentration; Kinetics; Leucine; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Photosynthetic Reaction Center Complex Proteins; Point Mutation; Recombinant Proteins; Rhodobacter capsulatus | 1995 |
Abolition of the inhibitory effect of ethanol oxidation on gluconeogenesis from lactate by asparagine or low concentrations of ammonia.
Topics: Ammonia; Animals; Asparagine; Aspartic Acid; Ethanol; Fasting; Gluconeogenesis; Kinetics; Lactates; Lactic Acid; Liver; Male; Oxidation-Reduction; Rats; Rats, Wistar | 1995 |
Destabilization of a protein helix by electrostatic interactions.
Topics: Asparagine; Aspartic Acid; Base Sequence; Chemical Phenomena; Chemistry, Physical; DNA Primers; Glutamates; Hot Temperature; Hydrogen-Ion Concentration; Ions; Models, Molecular; Molecular Sequence Data; Protein Denaturation; Recombinant Proteins; Ribonuclease T1; Thermodynamics | 1995 |
Proton transfer in cytochrome bo3 ubiquinol oxidase of Escherichia coli: second-site mutations in subunit I that restore proton pumping in the mutant Asp135-->Asn.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Electron Transport; Electron Transport Complex IV; Escherichia coli; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; Proton Pumps; Structure-Activity Relationship | 1995 |
Kinetics and crystal structure of a mutant Escherichia coli alkaline phosphatase (Asp-369-->Asn): a mechanism involving one zinc per active site.
Topics: Alanine; Alkaline Phosphatase; Asparagine; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Escherichia coli; Kinetics; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Tertiary; Zinc | 1994 |
Structure and function of the catalytic site mutant Asp 99 Asn of phospholipase A2: absence of the conserved structural water.
Topics: Animals; Asparagine; Aspartic Acid; Binding Sites; Cattle; Computer Graphics; Crystallography, X-Ray; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Pancreas; Phospholipases A; Phospholipases A2; Point Mutation; Water | 1994 |
Effect of aspartate, asparagine, and carnitine supplementation in the diet on metabolism of skeletal muscle during a moderate exercise.
Topics: Animals; Asparagine; Aspartic Acid; Blood Glucose; Carnitine; Citrate (si)-Synthase; Diet; Fatty Acids; Glycogen; Liver Glycogen; Male; Muscle, Skeletal; Oxaloacetates; Oxidation-Reduction; Physical Conditioning, Animal; Physical Exertion; Rats; Rats, Wistar; Swimming | 1995 |
Yeast N-terminal amidase. A new enzyme and component of the N-end rule pathway.
Topics: Acyltransferases; Amidohydrolases; Amino Acid Sequence; Amino Acids; Aminoacyltransferases; Asparagine; Aspartic Acid; Base Sequence; Carbohydrate Sequence; Cloning, Molecular; Codon; Fungal Proteins; Genes, Fungal; Glutamic Acid; Glutamine; Half-Life; Ligases; Models, Molecular; Molecular Sequence Data; Multienzyme Complexes; Promoter Regions, Genetic; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ubiquitin-Protein Ligases | 1995 |
Experimental evidence for hydrogen-bonded network proton transfer in bacteriorhodopsin shown by Fourier-transform infrared spectroscopy using azide as catalyst.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Azides; Bacteriorhodopsins; Binding Sites; Catalysis; Halobacterium; Hydrogen Bonding; Mutagenesis; Point Mutation; Protein Conformation; Protons; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared | 1995 |
Computer modelling of the alpha-helical coiled coil: packing of side-chains in the inner core.
Topics: Alanine; Amino Acid Sequence; Arginine; Asparagine; Aspartic Acid; Computer Simulation; Cysteine; Glutamates; Glutamine; Histidine; Hydrogen Bonding; Isoleucine; Leucine; Lysine; Methionine; Models, Molecular; Molecular Sequence Data; Protein Structure, Secondary; Serine; Thermodynamics; Threonine; Tyrosine; Valine | 1995 |
Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Base Sequence; Calcineurin; Calcium; Calmodulin; Calmodulin-Binding Proteins; Cloning, Molecular; Dose-Response Relationship, Drug; Interleukin-2; Ionomycin; Lymphoma, T-Cell; Mice; Molecular Mimicry; Molecular Sequence Data; Mutation; Peptide Fragments; Phosphoprotein Phosphatases; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Signal Transduction; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1995 |
Paraquat--a superoxide generator--kills neurons in the rat spinal cord.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Cell Death; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Microdialysis; Neurons; Neurotoxins; Paraquat; Rats; Rats, Sprague-Dawley; Spinal Cord; Superoxides; Synapses; Time Factors | 1995 |
Use of a purified heterodimer to test negative cooperativity as the basis of substrate inactivation of Escherichia coli thymidylate synthase (Asn177-->Asp).
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Cloning, Molecular; Escherichia coli; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Point Mutation; Protein Structure, Secondary; Recombinant Proteins; Thymidylate Synthase | 1994 |
Site-specificity of the second-site suppressor mutation of the Asp-285-->Asn mutant of metal-tetracycline/H+ antiporter of Escherichia coli and the effects of amino acid substitutions at the first and second sites.
Topics: Amino Acid Sequence; Antiporters; Asparagine; Aspartic Acid; Bacterial Proteins; Biological Transport; Escherichia coli; Glutamic Acid; Molecular Sequence Data; Mutagenesis, Site-Directed; Structure-Activity Relationship; Suppression, Genetic; Tetracycline | 1995 |
Substitution of Asp for Asn at position 132 in the active site of TEM beta-lactamase. Activity toward different substrates and effects of neighboring residues.
Topics: Asparagine; Aspartic Acid; Base Sequence; beta-Lactamases; Binding Sites; Catalysis; DNA Primers; Hydrogen-Ion Concentration; Molecular Sequence Data; Mutagenesis | 1995 |
Circadian variations of amino acid content of suprachiasmatic nucleus in rats.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Circadian Rhythm; Glycine; Light; Male; Rats; Rats, Wistar; Serine; Suprachiasmatic Nucleus | 1994 |
Activation of an Asp-124-->Asn mutant of haloalkane dehalogenase by hydrolytic deamidation of asparagine.
Topics: Amides; Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Deamination; DNA Primers; Enzyme Activation; Hydrolases; Hydrolysis; Molecular Sequence Data; Mutation; Point Mutation | 1995 |
Carbohydrate moiety of the Petunia inflata S3 protein is not required for self-incompatibility interactions between pollen and pistil.
Topics: Asparagine; Aspartic Acid; Base Sequence; Carbohydrates; Codon; DNA, Plant; Genotype; Molecular Sequence Data; Plant Proteins; Plants, Genetically Modified; Pollen; Reproduction; RNA, Plant; Transformation, Genetic | 1994 |
Asp187Asn mutation of gelsolin in an American kindred with familial amyloidosis, Finnish type (FAP IV).
Topics: Adult; Aged; Amyloidosis; Asparagine; Aspartic Acid; Base Sequence; Child; Child, Preschool; Chromosomes, Human, Pair 9; DNA Mutational Analysis; DNA Primers; Female; Finland; Gelsolin; Haplotypes; Humans; Male; Molecular Epidemiology; Molecular Sequence Data; Pedigree; Point Mutation; United States | 1995 |
The amino acid sequences of two postsynaptic neurotoxins isolated from Malayan cobra (Naja naja sputatrix) venom.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Elapid Venoms; Elapidae; Molecular Sequence Data; Neurotoxins; Sequence Homology, Amino Acid; Structure-Activity Relationship | 1994 |
Analysis of aspartic acid and asparagine metabolism in Xenopus laevis oocytes using a simple and sensitive HPLC method.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Female; Kinetics; Oocytes; Sensitivity and Specificity; Time Factors; Tritium; Xenopus laevis | 1994 |
Role of the active-site carboxylate in dihydrofolate reductase: kinetic and spectroscopic studies of the aspartate 26-->asparagine mutant of the Lactobacillus casei enzyme.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Lacticaseibacillus casei; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Oxidation-Reduction; Point Mutation; Spectrophotometry; Tetrahydrofolate Dehydrogenase | 1995 |
(2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate.
Topics: Amino Acids, Dicarboxylic; Animals; Anti-Bacterial Agents; Asparagine; Aspartic Acid; Astrocytes; Cell Membrane; Cells, Cultured; Depression, Chemical; Female; Glutamates; Glutamic Acid; Hippocampus; Kinetics; Neuroglia; Neurons; Pregnancy; Rats; Rats, Wistar; Stereoisomerism; Synaptosomes | 1993 |
Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Cell Line; Glutamates; Glutamic Acid; Glutamine; Kinetics; Light; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Proteins; Retinaldehyde; Rhodopsin; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Time Factors; Transfection | 1993 |
Second-site mutation of Ala-220 to Glu or Asp suppresses the mutation of Asp-285 to Asn in the transposon Tn10-encoded metal-tetracycline/H+ antiporter of Escherichia coli.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Antiporters; Asparagine; Aspartic Acid; Bacterial Proteins; Base Sequence; Biological Transport; DNA Transposable Elements; DNA, Bacterial; Escherichia coli; Glutamates; Glutamic Acid; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Protein Structure, Secondary; Repressor Proteins; Suppression, Genetic; Tetracycline | 1993 |
Three new mutations of thyroid hormone receptor-beta associated with resistance to thyroid hormone.
Topics: Adolescent; Adult; Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Drug Resistance; Female; Glutamates; Glutamic Acid; Glutamine; Humans; Lysine; Male; Molecular Sequence Data; Point Mutation; Receptors, Thyroid Hormone; Sicily; Syndrome; Thyroid Hormones | 1994 |
Replacement of Asp333 with Asn by site-directed mutagenesis changes the substrate specificity of Escherichia coli adenylosuccinate synthetase from guanosine 5'-triphosphate to xanthosine 5'-triphosphate.
Topics: Adenylosuccinate Synthase; Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Circular Dichroism; DNA, Complementary; Escherichia coli; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Ribonucleotides; Substrate Specificity | 1994 |
The role of intramolecular nucleophilic catalysis and the effects of self-association on the deamidation of human insulin at low pH.
Topics: Amides; Amino Acid Sequence; Anilides; Asparagine; Aspartic Acid; Catalysis; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Insulin; Molecular Sequence Data; Zinc | 1994 |
Dominant lethal mutations in the plasma membrane H(+)-ATPase gene of Saccharomyces cerevisiae.
Topics: Asparagine; Aspartic Acid; Cell Membrane; Fluorescent Antibody Technique; Genes, Dominant; Genes, Fungal; Genes, Lethal; Genes, Recessive; Microscopy, Fluorescence; Plasmids; Point Mutation; Proton-Translocating ATPases; Restriction Mapping; Saccharomyces cerevisiae | 1994 |
The mechanism of irreversible inactivation of lysozyme at pH 4 and 100 degrees C.
Topics: Acetylcysteine; Animals; Asparagine; Aspartic Acid; Chickens; Chromatography, High Pressure Liquid; Densitometry; Electrophoresis, Polyacrylamide Gel; Energy Metabolism; Enzyme Stability; Hydrogen-Ion Concentration; Hydrolysis; Isomerism; Muramidase; o-Phthalaldehyde; Protein Conformation; Protein Denaturation; Temperature | 1994 |
Liquid chromatographic-mass spectrometric analysis of N-acetylamino acids in human urine.
Topics: Acetylation; Amino Acids; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Glutamates; Glutamine; Humans; Lysine; Mass Spectrometry; Regression Analysis; Serine | 1994 |
Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (ASP549 to ASN) impairs C3 secretion.
Topics: Alleles; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Base Sequence; Complement C3; DNA; DNA Primers; Female; Fibroblasts; Gene Library; Humans; L Cells; Male; Mice; Molecular Sequence Data; Molecular Weight; Pedigree; Peptide Fragments; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; RNA, Messenger; Sequence Homology, Amino Acid; Transfection | 1994 |
L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a.
Topics: Alanine Transaminase; Animals; Asparagine; Aspartic Acid; Cell Line; Cell Membrane; Cricetinae; Cycloleucine; Cysteine; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamate Decarboxylase; Glutamic Acid; Hydrolysis; Kidney; N-Methylaspartate; Phosphatidylinositols; Pyrrolidines; Receptors, Metabotropic Glutamate | 1994 |
A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Base Sequence; Binding Sites; Cell Membrane; Conserved Sequence; Glutamic Acid; Ion Channel Gating; Leukemia, Erythroblastic, Acute; Magnesium; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Structure, Secondary; Transfection; Tumor Cells, Cultured | 1994 |
Synergistic anti-human immunodeficiency virus type 1 effect of hydroxamate compounds with 2',3'-dideoxyinosine in infected resting human lymphocytes.
Topics: Antiviral Agents; Asparagine; Aspartic Acid; Cell Survival; Cells, Cultured; Didanosine; Drug Synergism; HIV Infections; Humans; Hydroxyurea; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Virus Replication; Zalcitabine; Zidovudine | 1994 |
Determination of beta-isomerized aspartic acid as the corresponding alcohol.
Topics: Aluminum Compounds; Amino Acids; Asparagine; Aspartic Acid; Boranes; Cataract; Chymotrypsin; Crystallins; Homoserine; Humans; Indicators and Reagents; Isomerism; Lithium Compounds; Ovalbumin; Proteins; Succinimides; Tetragastrin | 1994 |
Selection for the expression of one form of Chinese hamster dihydrofolate reductase over another during growth in methotrexate.
Topics: Alleles; Animals; Asparagine; Aspartic Acid; Blotting, Southern; Cell Division; Cell Survival; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; DNA, Complementary; Methotrexate; Plasmids; Restriction Mapping; Selection, Genetic; Tetrahydrofolate Dehydrogenase; Transfection | 1994 |
The effect of the Asn82-->Asp mutation in yeast cytochrome c peroxidase studied by proton NMR spectroscopy.
Topics: Asparagine; Aspartic Acid; Cytochrome-c Peroxidase; Histidine; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Mutation; Saccharomyces cerevisiae | 1994 |
Site-directed mutagenesis of the histamine H1 receptor: roles of aspartic acid107, asparagine198 and threonine194.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Base Sequence; CHO Cells; Cricetinae; Gene Expression; Histamine; Humans; Inositol Phosphates; Molecular Sequence Data; Mutagenesis, Site-Directed; Pyrilamine; Receptors, Histamine H1; Structure-Activity Relationship; Threonine | 1994 |
An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Male; Microinjections; Nerve Degeneration; Niacin; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Serine; Threonine | 1993 |
Clarification of the pH-dependent kinetic behaviour of papain by using reactivity probes and analysis of alkylation and catalysed acylation reactions in terms of multihydronic state models: implications for electrostatics calculations and interpretation o
Topics: Acylation; Alkylation; Asparagine; Aspartic Acid; Catalysis; Electrochemistry; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mutagenesis, Site-Directed; Papain; Substrate Specificity | 1993 |
On the molecular origin of charge heterogeneity of rat liver fatty acid-binding protein (Z-protein).
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Carrier Proteins; Chromatography, High Pressure Liquid; Electrochemistry; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Liver; Male; Molecular Sequence Data; Neoplasm Proteins; Nerve Tissue Proteins; Peptide Fragments; Protein Processing, Post-Translational; Rats; Rats, Wistar; Serine Endopeptidases | 1994 |
Investigating the role of conserved residue Asp134 in Escherichia coli ribonuclease HI by site-directed random mutagenesis.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Circular Dichroism; Conserved Sequence; DNA Primers; Enzyme Stability; Escherichia coli; Genes, Bacterial; Histidine; Hot Temperature; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Polymerase Chain Reaction; Protein Denaturation; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Ribonuclease H; Suppression, Genetic; Thermodynamics | 1994 |
Mutation of Asn128 to Asp of Phaseolus vulgaris leucoagglutinin (PHA-L) eliminates carbohydrate-binding and biological activity.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Base Sequence; Binding Sites; Carbohydrate Metabolism; Cells, Cultured; Cloning, Molecular; DNA; Fabaceae; Hemagglutination Tests; Humans; Leukocytes; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Nicotiana; Phytohemagglutinins; Plant Lectins; Plants, Medicinal; Plants, Toxic | 1993 |
Complete identification of C = O stretching vibrational bands of protonated aspartic acid residues in the difference infrared spectra of M and N intermediates versus bacteriorhodopsin.
Topics: Asparagine; Aspartic Acid; Bacteriorhodopsins; Carbon; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Oxygen; Protons; Spectroscopy, Fourier Transform Infrared | 1994 |
Characterization of the active site of p21 ras by electron spin-echo envelope modulation spectroscopy with selective labeling: comparisons between GDP and GTP forms.
Topics: Asparagine; Aspartic Acid; Binding Sites; Electron Spin Resonance Spectroscopy; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Ligands; Phosphates; Proto-Oncogene Proteins p21(ras); Recombinant Proteins; Threonine | 1994 |
Synthetic post-translationally modified human A beta peptide exhibits a markedly increased tendency to form beta-pleated sheets in vitro.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Asparagine; Aspartic Acid; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Protein Processing, Post-Translational; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Stereoisomerism | 1994 |
Mutagenesis, structure and function studies of thymidylate synthase.
Topics: Asparagine; Aspartic Acid; Binding Sites; Catalysis; Electron Spin Resonance Spectroscopy; Mutagenesis; Phosphates; Protein Conformation; Structure-Activity Relationship; Thymidylate Synthase; X-Ray Diffraction | 1993 |
Asp-->Asn substitutions in the putative calcium-binding site of the turnip crinkle virus coat protein affect virus movement in plants.
Topics: Asparagine; Aspartic Acid; Base Sequence; Biological Transport; Brassica; Calcium; Capsid; Molecular Sequence Data; Plant Viral Movement Proteins; Plant Viruses; RNA Viruses; Viral Proteins | 1993 |
In vitro aging of calmodulin generates isoaspartate at multiple Asn-Gly and Asp-Gly sites in calcium-binding domains II, III, and IV.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Binding Sites; Brain Chemistry; Calcium; Calmodulin; Cattle; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Lysine; Methylation; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; Time Factors; Trypsin | 1993 |
Studies of the major reovirus core protein sigma 2: reversion of the assembly-defective mutant tsC447 is an intragenic process and involves back mutation of Asp-383 to Asn.
Topics: Animals; Asparagine; Aspartic Acid; Base Sequence; Crosses, Genetic; Genes, Suppressor; Genes, Viral; L Cells; Mammalian orthoreovirus 3; Mice; Molecular Sequence Data; Mutagenesis; Orthoreovirus; Phenotype; Reoviridae; Viral Core Proteins | 1994 |
Crystal structures of mutant Pseudomonas aeruginosa p-hydroxybenzoate hydroxylases: the Tyr201Phe, Tyr385Phe, and Asn300Asp variants.
Topics: 4-Hydroxybenzoate-3-Monooxygenase; Asparagine; Aspartic Acid; Crystallization; Crystallography, X-Ray; Electrochemistry; Hydrogen Bonding; Hydrogen-Ion Concentration; Molecular Structure; Mutation; Parabens; Phenylalanine; Pseudomonas aeruginosa; Tyrosine | 1994 |
Site-directed mutagenesis of the serotonin 5-hydroxytrypamine2 receptor: identification of amino acids necessary for ligand binding and receptor activation.
Topics: 3T3 Cells; Amphetamines; Animals; Asparagine; Aspartic Acid; Binding, Competitive; Guanosine Triphosphate; Hydrolysis; Lysergic Acid Diethylamide; Mice; Mutagenesis, Site-Directed; Phosphatidylinositols; Radioligand Assay; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
Deamidation of HPr, a phosphocarrier protein of the phosphoenolpyruvate:sugar phosphotransferase system, involves asparagine 38 (HPr-1) and asparagine 12 (HPr-2) in isoaspartyl acid formation.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Bacillus subtilis; Bacterial Proteins; Base Sequence; Endopeptidases; Enterococcus faecalis; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Peptide Fragments; Phosphoenolpyruvate Sugar Phosphotransferase System; Recombinant Proteins; Staphylococcus; Thermodynamics | 1993 |
Hydrogen bonding interactions with the Schiff base of bacteriorhodopsin. Resonance Raman spectroscopy of the mutants D85N and D85A.
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspartic Acid; Bacteriorhodopsins; Binding Sites; Hydrogen Bonding; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Proteins; Schiff Bases; Spectrum Analysis, Raman | 1993 |
Pathway of proton transfer in bacterial reaction centers: second-site mutation Asn-M44-->Asp restores electron and proton transfer in reaction centers from the photosynthetically deficient Asp-L213-->Asn mutant of Rhodobacter sphaeroides.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Codon; Hydrogen-Ion Concentration; Kinetics; Light; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Oxidation-Reduction; Photosynthesis; Photosynthetic Reaction Center Complex Proteins; Protons; Rhodobacter sphaeroides; Sequence Homology, Amino Acid | 1993 |
Substitution of asparagine for aspartate-135 in subunit I of the cytochrome bo ubiquinol oxidase of Escherichia coli eliminates proton-pumping activity.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Cloning, Molecular; Conserved Sequence; Electron Transport Complex IV; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared | 1993 |
Spontaneous degradation of polypeptides at aspartyl and asparaginyl residues: effects of the solvent dielectric.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Electrochemistry; Hydrogen-Ion Concentration; Molecular Sequence Data; Molecular Structure; Peptides; Solvents; Stereoisomerism | 1993 |
Partial revertants of tryptophan synthetase alpha chain active site mutant Asp60-->Asn.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Binding Sites; Escherichia coli; Kinetics; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Mutagenesis; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Protein Structure, Secondary; Sequence Deletion; Tryptophan Synthase | 1993 |
Comparison of the protein and DNA approaches for the characterization of a beta-globin chain variant, hemoglobin Cocody [beta 21 (B3) Asp--->Asn], in a Caucasian patient.
Topics: Adult; Asparagine; Aspartic Acid; Base Sequence; Chromatography, High Pressure Liquid; DNA; Electrophoresis, Polyacrylamide Gel; Female; Genetic Variation; Globins; Hemoglobins, Abnormal; Humans; Isoelectric Focusing; Molecular Sequence Data; Pedigree; Polymerase Chain Reaction | 1993 |
Proton transport by a bacteriorhodopsin mutant, aspartic acid-85-->asparagine, initiated in the unprotonated Schiff base state.
Topics: Asparagine; Aspartic Acid; Bacteriorhodopsins; Biological Transport; Light; Membrane Potentials; Mutation; Protons; Schiff Bases; Spectrophotometry; Titrimetry | 1995 |
Protein conformational changes during the bacteriorhodopsin photocycle. A Fourier transform infrared/resonance Raman study of the alkaline form of the mutant Asp-85-->Asn.
Topics: Asparagine; Aspartic Acid; Bacteriorhodopsins; Halobacterium salinarum; Hydrogen-Ion Concentration; Kinetics; Point Mutation; Protein Conformation; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thermodynamics | 1995 |
Amino-acid-type-selective triple-resonance experiments.
Topics: Alanine; Amino Acid Sequence; Amino Acids; Asparagine; Aspartic Acid; Calcium-Binding Proteins; Carbon; Carrier Proteins; Cysteine; Glycine; Image Enhancement; Isoleucine; Magnetic Resonance Spectroscopy; Methionine; Microfilament Proteins; Nitrogen; Serine; Valine | 1996 |
Effects of Asn318 and Asp87Asn318 mutations on signal transduction by the gonadotropin-releasing hormone receptor and receptor regulation.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Buserelin; Cyclic AMP; Down-Regulation; Inositol Phosphates; Mice; Pituitary Neoplasms; Point Mutation; Prolactin; Rats; Receptors, LHRH; Signal Transduction; Tumor Cells, Cultured; Up-Regulation | 1996 |
Site-directed mutagenesis of human lysyl hydroxylase expressed in insect cells. Identification of histidine residues and an aspartic acid residue critical for catalytic activity.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Baculoviridae; Base Sequence; Binding Sites; Cell Line; Codon; Electrophoresis, Polyacrylamide Gel; Genetic Vectors; Histidine; Humans; Kinetics; Molecular Weight; Mutagenesis, Site-Directed; Point Mutation; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; Recombinant Proteins; Spodoptera; Transfection | 1996 |
An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins.
Topics: Amino Acid Sequence; Antigens, Neoplasm; Asparagine; Aspartic Acid; Clone Cells; Epitopes; HLA-A2 Antigen; Humans; Melanoma; Membrane Proteins; Models, Biological; Molecular Sequence Data; Monophenol Monooxygenase; Peptide Fragments; Protein Processing, Post-Translational; Tumor Cells, Cultured | 1996 |
Importance of two buried salt bridges in the stability and folding pathway of barnase.
Topics: Arginine; Asparagine; Aspartic Acid; Bacterial Proteins; Binding Sites; Calorimetry; Enzyme Stability; Kinetics; Mathematics; Models, Structural; Models, Theoretical; Mutagenesis, Site-Directed; Point Mutation; Protein Denaturation; Protein Engineering; Protein Folding; Protein Structure, Secondary; Recombinant Proteins; Ribonucleases; Thermodynamics; Urea | 1996 |
Synergistic contributions of asparagine 46 and aspartate 52 to the catalytic mechanism of chicken egg white lysozyme.
Topics: Animals; Asparagine; Aspartic Acid; Base Sequence; Binding Sites; Catalysis; Cell Wall; Chickens; Chitin; Escherichia coli; Female; In Vitro Techniques; Kinetics; Micrococcus luteus; Models, Molecular; Molecular Sequence Data; Molecular Structure; Muramidase; Oligodeoxyribonucleotides; Ovum; Point Mutation; Substrate Specificity | 1996 |
Kinetic and structural consequences of replacing the aspartate bridge by asparagine in the catalytic metal triad of Escherichia coli alkaline phosphatase.
Topics: Alkaline Phosphatase; Asparagine; Aspartic Acid; Crystallography, X-Ray; Enzyme Activation; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Mutation | 1996 |
Modulation of a salt link does not affect binding of phosphate to its specific active transport receptor.
Topics: Asparagine; Aspartic Acid; Biological Transport, Active; Carrier Proteins; Chlorides; Electrochemistry; Hydrogen Bonding; Mutagenesis, Site-Directed; Phosphates; Protein Conformation; Salts | 1996 |
Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.
Topics: Asparagine; Aspartic Acid; Binding Sites; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Electrochemistry; Glutamic Acid; Glycine; Humans; Hydrazines; Imines; Mixed Function Oxygenases; Models, Molecular; Molecular Structure; Mutation; Protoporphyrins; Saccharomyces cerevisiae; Structure-Activity Relationship | 1996 |
Hydrogen bonds of water and C==O groups coordinate long-range structural changes in the L photointermediate of bacteriorhodopsin.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Bacteriorhodopsins; Carbon Isotopes; Halobacterium; Hydrogen Bonding; Kinetics; Light; Methionine; Models, Molecular; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared; Valine | 1996 |
Preliminary functional studies of mutant D114N of Clostridium symbiosum glutamate dehydrogenase.
Topics: Asparagine; Aspartic Acid; Clostridium; Codon; Glutamate Dehydrogenase; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Point Mutation; Recombinant Proteins | 1996 |
A unique genetic and biochemical presentation of fish-eye disease.
Topics: Aged; Aged, 80 and over; Amino Acid Sequence; Apolipoprotein A-I; Asparagine; Aspartic Acid; Base Sequence; Cholesterol, HDL; DNA Primers; Genetic Carrier Screening; Homozygote; Humans; Lecithin Cholesterol Acyltransferase Deficiency; Lipoprotein(a); Lipoproteins, HDL; Male; Middle Aged; Molecular Sequence Data; Pedigree; Phenotype; Phosphatidylcholine-Sterol O-Acyltransferase; Point Mutation; Polymerase Chain Reaction; Reference Values; Restriction Mapping | 1995 |
Functional properties of the histidine-aspartate ion pair of flavocytochrome b2 (L-lactate dehydrogenase): substitution of Asp282 with asparagine.
Topics: Asparagine; Aspartic Acid; Escherichia coli; Histidine; Ions; Isotopes; Kinetics; L-Lactate Dehydrogenase; L-Lactate Dehydrogenase (Cytochrome); Lactates; Lactic Acid; Mutagenesis, Site-Directed; Recombinant Proteins | 1996 |
Mapping the aspartic acid binding site of Escherichia coli asparagine synthetase B using substrate analogs.
Topics: Alkylation; Antineoplastic Agents; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Bacterial Proteins; Binding Sites; Drug Design; Enzyme Inhibitors; Escherichia coli; Glutamine; Humans; Isoenzymes; Kinetics; Molecular Conformation; Molecular Structure; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 1996 |
Genetic evidence for involvement of multiple effector systems in alpha 2A-adrenergic receptor inhibition of stimulus-secretion coupling.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenocorticotropic Hormone; Analysis of Variance; Animals; Asparagine; Aspartic Acid; Barium; Brimonidine Tartrate; Calcium Channels; Cell Line; GTP-Binding Proteins; Isoproterenol; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pituitary Gland, Anterior; Point Mutation; Potassium Channels; Quinoxalines; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Somatostatin | 1996 |
Two mutations of the lutropin/choriogonadotropin receptor that impair signal transduction also interfere with receptor-mediated endocytosis.
Topics: Arginine; Asparagine; Aspartic Acid; Cell Line; Chorionic Gonadotropin; Cyclic AMP; Embryo, Mammalian; Endocytosis; Histidine; Humans; Kidney; Mutagenesis; Protein Conformation; Receptors, LH; Signal Transduction; Transfection | 1996 |
Effects of 7B2 on the maturation of pro-hormone convertase 2 (PC2) in vitro.
Topics: Animals; Asparagine; Aspartic Acid; Female; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Neuroendocrine Secretory Protein 7B2; Oocytes; Pituitary Hormones; Point Mutation; Polymerase Chain Reaction; Proprotein Convertase 2; Protein Processing, Post-Translational; Recombinant Proteins; Serine; Subtilisins; Xenopus laevis | 1996 |
Changes in the intracellular free amino acid pool in human saphenous vein tissue culture.
Topics: Aged; Alanine; Amino Acids; Asparagine; Aspartic Acid; Culture Techniques; Cytosol; Glutamic Acid; Glutamine; Glycine; Humans; Middle Aged; Proline; Saphenous Vein; Serine; Taurine | 1996 |
Unaccustomed high-mileage vs intensity training-related changes in performance and serum amino acid levels.
Topics: Adult; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cystine; Erythrocyte Count; Exercise Test; Fatigue; Glycine; Hematocrit; Hemoglobins; Humans; Lactates; Leukocyte Count; Lysine; Methionine; Phenylalanine; Physical Endurance; Prospective Studies; Running; Serine; Taurine; Tryptophan; Tyrosine | 1996 |
Defective cystathionine beta-synthase regulation by S-adenosylmethionine in a partially pyridoxine responsive homocystinuria patient.
Topics: Adult; Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Cystathionine beta-Synthase; DNA; DNA Primers; Female; Gene Expression Regulation, Enzymologic; Heterozygote; Homocystinuria; Homozygote; Humans; Male; Molecular Sequence Data; Pedigree; Point Mutation; Polymerase Chain Reaction; Pyridoxine; Reference Values; S-Adenosylmethionine | 1996 |
Versatility of heme coordination demonstrated in a fungal peroxidase. Absorption and resonance Raman studies of Coprinus cinereus peroxidase and the Asp245-->Asn mutant at various pH values.
Topics: Asparagine; Aspartic Acid; Catalysis; Coprinus; Ferrous Compounds; Heme; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Peroxidases; Spectrum Analysis, Raman | 1996 |
Effect of D42N substitution in Escherichia coli inorganic pyrophosphatase on catalytic activity and Mg2+ binding.
Topics: Asparagine; Aspartic Acid; Catalysis; Escherichia coli; Fluorides; Hydrolysis; Inorganic Pyrophosphatase; Magnesium; Mutagenesis, Site-Directed; Pyrophosphatases; Substrate Specificity | 1996 |
Identification of transmembrane domain residues determinant in the structure-function relationship of the human platelet-activating factor receptor by site-directed mutagenesis.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Azepines; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein Conformation; Proto-Oncogene Proteins c-myc; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Transfection; Triazoles | 1996 |
Myristoylation-dependent and electrostatic interactions exert independent effects on the membrane association of the myristoylated alanine-rich protein kinase C substrate protein in intact cells.
Topics: Acylation; Animals; Asparagine; Aspartic Acid; Binding Sites; Chick Embryo; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microscopy, Immunoelectron; Mutagenesis; Myristic Acid; Myristic Acids; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Proteins; Recombinant Proteins; Serine; Species Specificity; Static Electricity; Subcellular Fractions | 1996 |
A glutamate/glutamine/aspartate/asparagine transport operon in Rhodobacter capsulatus.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Asparagine; Aspartic Acid; Biological Transport; Carrier Proteins; Chromosome Mapping; Cloning, Molecular; Glutamic Acid; Glutamine; Molecular Sequence Data; Operon; Rhodobacter capsulatus; Sequence Homology, Amino Acid | 1996 |
A partially functional DNA helicase II mutant defective in forming stable binary complexes with ATP and DNA. A role for helicase motif III.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Alleles; Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; DNA; DNA Helicases; DNA, Viral; Escherichia coli; Escherichia coli Proteins; Kinetics; Mutagenesis, Site-Directed; Peptide Fragments; Recombinant Proteins; Restriction Mapping; Ultraviolet Rays | 1996 |
Common genetic variants of lipoprotein lipase that relate to lipid transport in patients with premature coronary artery disease.
Topics: Asparagine; Aspartic Acid; Coronary Artery Disease; Genetic Variation; Humans; Lipid Metabolism; Lipoprotein Lipase; Lipoproteins; Middle Aged; Point Mutation; Serine | 1995 |
Determination of two sites of automethylation in bovine erythrocyte protein (D-aspartyl/L-isoaspartyl) carboxyl methyltransferase.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Binding Sites; Cattle; Chromatography, High Pressure Liquid; Cyanogen Bromide; Erythrocytes; Methylation; Molecular Sequence Data; Peptide Mapping; Peptides; Protein O-Methyltransferase; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin | 1996 |
Genetic diagnosis of dysplasminogenemia: detection of an Ala601-Thr mutation in 118 out of 125 families and identification of a new Asp676-Asn mutation.
Topics: Adult; Alanine; Asparagine; Aspartic Acid; Female; Genetic Testing; Humans; Male; Mutation; Phenylalanine; Plasminogen; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single-Stranded Conformational; Sequence Analysis, DNA; Structure-Activity Relationship; Threonine; Thrombosis | 1996 |
Electric-field-induced Schiff-base deprotonation in D85N mutant bacteriorhodopsin.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Bacteriorhodopsins; Electrochemistry; Genetic Variation; Halobacterium; Hydrogen-Ion Concentration; Kinetics; Point Mutation; Schiff Bases; Spectrophotometry; Time Factors | 1996 |
Neurotransmitter amino acids in cerebrospinal fluid of patients with Parkinson's disease.
Topics: Aged; Amino Acids; Asparagine; Aspartic Acid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Glycine; Humans; Male; Middle Aged; Neurotransmitter Agents; Parkinson Disease | 1996 |
Stabilization of lysozyme by introducing N-glycosylation signal sequence.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Enzyme Stability; Glycosylation; Guanidine; Guanidines; Molecular Sequence Data; Muramidase; Mutation; Protein Conformation; Protein Denaturation; Protein Folding; Protein Sorting Signals; Recombinant Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship | 1996 |
Monitoring of asparaginase activity and asparagine levels in children on different asparaginase preparations.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Child, Preschool; Glutamic Acid; Glutamine; Humans; Infant; Infant, Newborn; Lymphoma, Non-Hodgkin; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1996 |
Substrate binding mechanism of Glu180-->Gln, Asp176-->Asn, and wild-type glucoamylases from Aspergillus niger.
Topics: Asparagine; Aspartic Acid; Aspergillus niger; Glucan 1,4-alpha-Glucosidase; Glutamic Acid; Glutamine; Kinetics; Models, Chemical; Point Mutation; Protein Binding; Thermodynamics | 1996 |
Compound heterozygosity for a known and a novel defect in the lipoprotein lipase gene (Asp250-->Asn; Ser251-->Cys) resulting in lipoprotein lipase (LPL) deficiency.
Topics: Adolescent; Asparagine; Aspartic Acid; Cysteine; Denmark; DNA; Heterozygote; Humans; Hyperlipoproteinemia Type I; Hypertriglyceridemia; Lipoprotein Lipase; Male; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Serine | 1996 |
Intracellular acidification of the leech giant glial cell evoked by glutamate and aspartate.
Topics: 2-Aminoadipic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acids; Animals; Antineoplastic Agents; Asparagine; Aspartic Acid; Calcium; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ganglia, Invertebrate; Glutamic Acid; Hydrogen-Ion Concentration; Kainic Acid; Leeches; Membrane Potentials; Neuroglia; Patch-Clamp Techniques; Sodium | 1997 |
Charged residues in transmembrane domains II and XI of a vesicular monoamine transporter form a charge pair that promotes high affinity substrate recognition.
Topics: Animals; Asparagine; Aspartic Acid; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Humans; Kinetics; Lysine; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Mutagenesis, Site-Directed; Neuropeptides; Neurotransmitter Agents; Rats; Reserpine; Serotonin; Structure-Activity Relationship; Substrate Specificity; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1997 |
Mechanism of Ca2+ and monosaccharide binding to a C-type carbohydrate-recognition domain of the macrophage mannose receptor.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Binding Sites; Calcium; Kinetics; Lectins; Lectins, C-Type; Macrophages; Magnetic Resonance Spectroscopy; Mannose Receptor; Mannose-Binding Lectins; Mice; Models, Molecular; Monosaccharides; Mutagenesis, Site-Directed; Phenotype; Rats; Receptors, Cell Surface; Tyrosine | 1997 |
Substrate recognition of isocitrate dehydrogenase and 3-isopropylmalate dehydrogenase from Thermus thermophilus HB8.
Topics: 3-Isopropylmalate Dehydrogenase; Alcohol Oxidoreductases; Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Glutamic Acid; Isocitrate Dehydrogenase; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Serine; Substrate Specificity; Thermus thermophilus | 1997 |
Isolation and characterization of Rhizobium etli mutants altered in degradation of asparagine.
Topics: Asparaginase; Asparagine; Aspartate Ammonia-Lyase; Aspartic Acid; Cloning, Molecular; Enzyme Stability; Genes, Bacterial; Genetic Complementation Test; Glutamic Acid; Glutamine; Isoenzymes; Mutation; Nitrogenase; Rhizobium; Temperature | 1997 |
PMR1, a Ca2+-ATPase in yeast Golgi, has properties distinct from sarco/endoplasmic reticulum and plasma membrane calcium pumps.
Topics: Adenosine Triphosphate; Asparagine; Aspartic Acid; Calcium; Calcium-Transporting ATPases; Cell Membrane; Endoplasmic Reticulum; Enzyme Inhibitors; Evolution, Molecular; Glutamine; Golgi Apparatus; Heat-Shock Proteins; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Saccharomyces cerevisiae; Sarcoplasmic Reticulum | 1997 |
Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotropin-releasing hormone receptor.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Binding Sites; Computer Simulation; Conserved Sequence; COS Cells; Inositol Phosphates; Models, Structural; Mutagenesis, Site-Directed; Point Mutation; Protein Structure, Secondary; Receptors, Thyrotropin-Releasing Hormone; Recombinant Proteins; Thermodynamics; Thyrotropin-Releasing Hormone; Transfection | 1997 |
[Regulatory role of the excitatory amino acid system in the neuromediator response of the hypothalamus to stress].
Topics: Adaptation, Physiological; Animals; Asparagine; Aspartic Acid; Excitatory Amino Acids; Hypothalamus; Male; Microdialysis; Neurotransmitter Agents; Rats; Rats, Wistar; Stress, Physiological | 1996 |
The tertiary structural changes in bacteriorhodopsin occur between M states: X-ray diffraction and Fourier transform infrared spectroscopy.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Bacteriorhodopsins; Catalysis; Darkness; Guanidine; Guanidines; Halobacterium; Light; Point Mutation; Protein Denaturation; Protein Structure, Tertiary; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 1997 |
Mutagenesis and chemical rescue indicate residues involved in beta-aspartyl-AMP formation by Escherichia coli asparagine synthetase B.
Topics: Adenosine Monophosphate; Amino Acid Sequence; Arginine; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Escherichia coli; Glutamine; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; Sequence Alignment; Software; Structure-Activity Relationship; Threonine | 1997 |
N-glycosylation at the conserved sites ensures the expression of properly folded functional ACh receptors.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Binding Sites; Bungarotoxins; Cloning, Molecular; Conserved Sequence; Female; Glycosylation; Ion Channels; Kinetics; Macromolecular Substances; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Point Mutation; Protein Folding; Receptors, Cholinergic; RNA, Messenger; Xenopus laevis | 1997 |
The residues Leu 93 and Asp 96 act independently in the bacteriorhodopsin photocycle: studies with the leu 93-->Ala, Asp 96-->Asn double mutant.
Topics: Alanine; Asparagine; Aspartic Acid; Bacteriorhodopsins; Halobacterium; Hydrogen-Ion Concentration; Kinetics; Leucine; Light; Models, Molecular; Mutagenesis, Site-Directed; Photochemistry; Point Mutation; Protein Conformation; Recombinant Proteins; Schiff Bases; Spectrophotometry; Time Factors | 1996 |
Microdialysis of human breast tissue during the menstrual cycle.
Topics: Adipose Tissue; Adult; Amino Acids; Asparagine; Aspartic Acid; Breast; Chromatography, High Pressure Liquid; Female; Glycine; Humans; Lactic Acid; Menstrual Cycle; Microdialysis; Ornithine; Pyruvic Acid; Serine; Threonine; Tyrosine | 1997 |
Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice.
Topics: Animals; Asparagine; Aspartic Acid; Body Weight; Death, Sudden; DNA Primers; Female; Growth Disorders; Heterozygote; Humans; Infant, Newborn; Male; Mice; Mice, Knockout; Pentylenetetrazole; Polymerase Chain Reaction; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; Proteins; Recombinant Proteins; Restriction Mapping; Seizures | 1997 |
Methanol production during chemotaxis to amino acids in Bacillus subtilis.
Topics: Amino Acids; Asparagine; Aspartic Acid; Bacillus subtilis; Bacterial Proteins; CDC2 Protein Kinase; Chemoreceptor Cells; Chemotaxis; Membrane Proteins; Methanol; Methyl-Accepting Chemotaxis Proteins; Proteins | 1997 |
Inhibition of the M1-->M2 (M(closed) --> M(open)) transition in the D96N mutant photocycle and its relation to the corresponding transition in wild-type bacteriorhodopsin.
Topics: Asparagine; Aspartic Acid; Bacteriorhodopsins; Kinetics; Mutagenesis, Site-Directed; Photochemistry; Schiff Bases; Spectrophotometry; Thermodynamics | 1997 |
The 'Asx-Pro turn' as a local structural motif stabilized by alternative patterns of hydrogen bonds and a consensus-derived model of the sequence Asn-Pro-Asn.
Topics: Amino Acid Sequence; Animals; Antigens, Protozoan; Asparagine; Aspartic Acid; Binding Sites; Consensus Sequence; Databases, Factual; Hydrogen Bonding; Models, Chemical; Models, Molecular; Molecular Sequence Data; Plasmodium falciparum; Proline; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protozoan Proteins | 1997 |
Recognition of phage-expressed peptides containing Asx-Pro sequences by monoclonal antibodies produced against Plasmodium falciparum circumsporozoite protein.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibodies, Protozoan; Asparagine; Aspartic Acid; Bacteriophages; Base Sequence; DNA, Recombinant; Enzyme-Linked Immunosorbent Assay; Epitope Mapping; Genetic Vectors; Molecular Sequence Data; Peptides; Plasmodium falciparum; Proline; Protein Conformation; Protozoan Proteins; Recombinant Proteins | 1997 |
Thermodynamic characterization of the binding of dCMP to the Asn229Asp mutant of thymidylate synthase.
Topics: Asparagine; Aspartic Acid; Calorimetry; Deoxycytidine Monophosphate; Dialysis; Mutation; Protein Binding; Temperature; Thermodynamics; Thymidylate Synthase | 1997 |
Specific racemization and isomerization of the aspartyl residue of alphaA-crystallin due to UV-B irradiation.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Crystallins; Isomerism; Molecular Sequence Data; Rats; Rats, Wistar; Ultraviolet Rays | 1997 |
Hydrogen bond network in the distal site of peroxidases: spectroscopic properties of Asn70 --> Asp horseradish peroxidase mutant.
Topics: Asparagine; Aspartic Acid; Binding Sites; Circular Dichroism; Cyanides; Horseradish Peroxidase; Hydrogen Bonding; Hydroxamic Acids; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Oxidation-Reduction; Spectroscopy, Fourier Transform Infrared | 1997 |
Effects of two hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on Ca2+ regulation of thin filament motility.
Topics: Actins; Animals; Asparagine; Aspartic Acid; Cardiomyopathy, Hypertrophic; Glutamic Acid; Glycine; Muscle, Skeletal; Mutation; Myosin Subfragments; Phalloidine; Rabbits; Rhodamines; Tropomyosin; Troponin | 1997 |
Recombinant human glycosylasparaginase catalyzes hydrolysis of L-asparagine.
Topics: Ammonia; Asparagine; Aspartic Acid; Aspartylglucosylaminase; Binding Sites; Binding, Competitive; Catalysis; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Hydrolysis; Recombinant Proteins | 1997 |
Glutamine homologues and derivatives: a limiting factor in current artificial nutrition?
Topics: Arginine; Asparagine; Aspartic Acid; Evaluation Studies as Topic; Glutamic Acid; Glutamine; Humans; Oxaloacetates; Parenteral Nutrition, Total | 1997 |
Supplementation of aspartate, asparagine and carnitine in the diet causes marked changes in the ultrastructure of soleus muscle.
Topics: Animals; Asparagine; Aspartic Acid; Carnitine; Diet; Male; Muscle, Skeletal; Physical Conditioning, Animal; Rats; Rats, Wistar | 1997 |
Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor.
Topics: Asparagine; Aspartic Acid; Aspartic Acid Endopeptidases; Binding Sites; Crystallography, X-Ray; Enzyme Activation; Immunodeficiency Virus, Feline; Macromolecular Substances; Mutagenesis, Site-Directed; Oligopeptides; Peptides; Protease Inhibitors; Solutions; Substrate Specificity | 1997 |
Functional effects on the acetylcholine receptor of multiple mutations of gamma Asp174 and delta Asp180.
Topics: Affinity Labels; Animals; Asparagine; Aspartic Acid; Binding, Competitive; Bungarotoxins; Histidine; Hydrogen-Ion Concentration; Membrane Potentials; Mice; Mutagenesis, Site-Directed; Quaternary Ammonium Compounds; Receptors, Cholinergic; Tubocurarine | 1997 |
Assessment of French patients with LPL deficiency for French Canadian mutations.
Topics: Alleles; Asparagine; Aspartic Acid; Canada; Female; France; Glycine; Humans; Lipoprotein Lipase; Male; Pedigree; Point Mutation | 1997 |
Analysis of the interaction of FtsZ with itself, GTP, and FtsA.
Topics: Asparagine; Aspartic Acid; Bacillus subtilis; Bacterial Proteins; Cytoskeletal Proteins; Escherichia coli; Escherichia coli Proteins; GTP Phosphohydrolases; Guanosine Triphosphate; Mutagenesis, Site-Directed; Peptide Fragments; Polymers; Protein Binding; Recombinant Fusion Proteins; Sequence Analysis; Trypsin | 1997 |
The last phase of the reprotonation switch in bacteriorhodopsin: the transition between the M-type and the N-type protein conformation depends on hydration.
Topics: Asparagine; Aspartic Acid; Bacteriorhodopsins; Mutagenesis, Insertional; Protein Conformation; Protons; Schiff Bases; Spectroscopy, Fourier Transform Infrared; Water; X-Ray Diffraction | 1997 |
Detection of two new polymorphic sites in the human interleukin-1 beta gene: lack of association with schizophrenia in a French population.
Topics: Adult; Alleles; Amino Acid Substitution; Asparagine; Aspartic Acid; Exons; Female; France; Gene Frequency; Genotype; Humans; Interleukin-1; Male; Middle Aged; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Restriction Mapping; Schizophrenia; Sequence Deletion | 1997 |
Analysis of deamidation of small, acid-soluble spore proteins from Bacillus subtilis in vitro and in vivo.
Topics: Asparagine; Aspartic Acid; Bacillus subtilis; Bacterial Proteins; DNA, Bacterial; Hot Temperature; Protein Conformation; Protein Structure, Secondary; Sigma Factor; Solubility; Spores, Bacterial; Transcription Factors | 1997 |
In vivo mutation of the alpha 2A-adrenergic receptor by homologous recombination reveals the role of this receptor subtype in multiple physiological processes.
Topics: Adrenergic alpha-Agonists; Amino Acid Sequence; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Blood Pressure; Brain; Cell Line; Conserved Sequence; Down-Regulation; Locus Coeruleus; Mice; Mice, Mutant Strains; Mutagenesis, Site-Directed; Point Mutation; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Recombination, Genetic; Transcription, Genetic | 1998 |
Evaluation of the role of specific acidic amino acid residues in electron transfer between the flavodoxin and cytochrome c3 from Desulfovibrio vulgaris.
Topics: Amino Acids, Dicarboxylic; Asparagine; Aspartic Acid; Cytochrome c Group; Desulfovibrio vulgaris; Electrochemistry; Electron Transport; Flavodoxin; Gene Expression Regulation, Bacterial; Glutamic Acid; Glutamine; Models, Molecular; Mutagenesis, Site-Directed; Osmolar Concentration | 1997 |
Structure and function of poly(3-hydroxybutyrate) depolymerase from Alcaligenes faecalis T1.
Topics: Alcaligenes; Asparagine; Aspartic Acid; Carboxylic Ester Hydrolases; Chromosome Inversion; DNA Primers; DNA, Bacterial; Gene Expression; Glycine; Histidine; Plasmids; Point Mutation; Polymerase Chain Reaction; Recombinant Fusion Proteins; Sequence Deletion; Serine; Trypsin | 1997 |
Diffuse thalamic degeneration in fatal familial insomnia. A morphometric study.
Topics: Adult; Asparagine; Aspartic Acid; Codon; Creutzfeldt-Jakob Syndrome; Fatal Outcome; Female; Humans; Male; Middle Aged; Nerve Degeneration; Neurons; Point Mutation; Prions; Reference Values; Sleep Initiation and Maintenance Disorders; Thalamic Nuclei | 1997 |
Regulatory phosphorylation of plant phosphoenolpyruvate carboxylase: role of a conserved basic residue upstream of the phosphorylation site.
Topics: Asparagine; Aspartic Acid; Binding Sites; Conserved Sequence; Enzyme Activation; Enzyme Inhibitors; Glucose-6-Phosphate; Lysine; Malates; Mutagenesis, Site-Directed; Phosphoenolpyruvate Carboxylase; Phosphorylation; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Serine; Zea mays | 1997 |
Nucleotide binding to Na,K-ATPase. Effect of ionic strength and charge.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Asparagine; Aspartic Acid; Kidney; Kinetics; Osmolar Concentration; Point Mutation; Protein Binding; Sodium-Potassium-Exchanging ATPase; Swine | 1997 |
Conserved active site aspartates and domain-domain interactions in regulatory properties of the sugar kinase superfamily.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Conserved Sequence; Escherichia coli; Escherichia coli Proteins; Fructosediphosphates; Glycerol Kinase; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Phosphoenolpyruvate Sugar Phosphotransferase System; Point Mutation; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins | 1998 |
The stability and degradation pathway of recombinant human parathyroid hormone: deamidation of asparaginyl residue and peptide bond cleavage at aspartyl and asparaginyl residues.
Topics: Amino Acid Sequence; Amino Acids; Asparagine; Aspartic Acid; Drug Stability; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Parathyroid Hormone; Peptide Fragments; Recombinant Proteins; Serine Endopeptidases; Spectrometry, Mass, Fast Atom Bombardment; Temperature; Trypsin | 1997 |
Aspartic acid 252 and asparagine 185 are essential for activity of lipid N-acetylglucosaminylphosphate transferase.
Topics: Alleles; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Cricetinae; Drug Resistance, Microbial; Gene Deletion; Gene Expression; Immunoblotting; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Schizosaccharomyces; Structure-Activity Relationship; Transferases (Other Substituted Phosphate Groups); Tunicamycin | 1997 |
Neurotransmitters in cerebrospinal fluid reflect pathological activity.
Topics: Adult; Aged; Asparagine; Aspartic Acid; Blood-Brain Barrier; Central Nervous System Diseases; Female; Glutamic Acid; Glutamine; Glycine; Humans; L-Lactate Dehydrogenase; Male; Middle Aged; Neurotransmitter Agents; Serine; Taurine | 1997 |
Structure and hydration of the M-state of the bacteriorhodopsin mutant D96N studied by neutron diffraction.
Topics: Asparagine; Aspartic Acid; Bacteriorhodopsins; Fourier Analysis; Halobacterium salinarum; Mutation; Neutrons; Purple Membrane; Schiff Bases; Water; X-Ray Diffraction | 1998 |
Cooperative folding of a protein mini domain: the peripheral subunit-binding domain of the pyruvate dehydrogenase multienzyme complex.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Circular Dichroism; Enzyme Stability; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptides; Protein Conformation; Protein Denaturation; Protein Folding; Pyruvate Dehydrogenase Complex; Thermodynamics | 1998 |
Biochemical characterization of the 20S proteasome from the methanoarchaeon Methanosarcina thermophila.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Sequence; Amino Acid Substitution; Archaeal Proteins; Arginine; Asparagine; Aspartic Acid; Base Sequence; Cloning, Molecular; Cysteine Endopeptidases; DNA, Archaeal; Escherichia coli; Glutamine; Ions; Lysine; Methanosarcina; Microscopy, Electron; Molecular Sequence Data; Multienzyme Complexes; Peptides; Phenylalanine; Plasmids; Polymerase Chain Reaction; Sequence Analysis, DNA; Sodium Dodecyl Sulfate; Threonine; Tyrosine | 1998 |
Local-access model for proton transfer in bacteriorhodopsin.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Bacteriorhodopsins; Electron Transport; Halobacterium salinarum; Hydrogen-Ion Concentration; Isomerism; Kinetics; Models, Biological; Mutagenesis, Site-Directed; Photochemistry; Protons; Retinaldehyde; Schiff Bases | 1998 |
Catalysis in human hypoxanthine-guanine phosphoribosyltransferase: Asp 137 acts as a general acid/base.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Catalysis; Glutamine; Guanosine Monophosphate; Humans; Hydrogen-Ion Concentration; Hypoxanthine Phosphoribosyltransferase; Inosine Monophosphate; Kinetics; Ligands; Lysine; Mutagenesis, Site-Directed; Polymerase Chain Reaction | 1998 |
The crystal structure of asparaginyl-tRNA synthetase from Thermus thermophilus and its complexes with ATP and asparaginyl-adenylate: the mechanism of discrimination between asparagine and aspartic acid.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Amino Acyl-tRNA Synthetases; Asparagine; Aspartate-tRNA Ligase; Aspartic Acid; Crystallography, X-Ray; Dimerization; Models, Molecular; Molecular Sequence Data; Protein Conformation; RNA, Transfer, Amino Acyl; Sequence Homology, Amino Acid; Thermus thermophilus | 1998 |
Molecular cloning of the cDNA encoding the carboxy-terminal domain of chimpanzee apolipoprotein(a): an Asp57 --> Asn mutation in kringle IV-10 is associated with poor fibrin binding.
Topics: Amino Acid Substitution; Animals; Apolipoproteins; Apoprotein(a); Asparagine; Aspartic Acid; Cloning, Molecular; DNA, Complementary; Female; Fibrin; Humans; Kringles; Lipoprotein(a); Macaca mulatta; Mutation; Pan troglodytes; Plasminogen; Protein Binding; Protein Structure, Tertiary | 1998 |
Involvement of glutamic acid 278 in the redox reaction of the cytochrome c oxidase from Paracoccus denitrificans investigated by FTIR spectroscopy.
Topics: Asparagine; Aspartic Acid; Deuterium Oxide; Electron Transport Complex IV; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Oxidation-Reduction; Paracoccus denitrificans; Serine; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared | 1998 |
The chromophore induces a correct folding of the polypeptide chain of bacteriorhodopsin.
Topics: Amino Acid Substitution; Apoproteins; Asparagine; Aspartic Acid; Bacteriorhodopsins; Circular Dichroism; Halobacterium salinarum; Hydrogen-Ion Concentration; Hydroxylamine; Mutagenesis, Site-Directed; Peptides; Photolysis; Protein Conformation; Protein Folding; Retinal Pigments; Schiff Bases | 1998 |
Measurement of altered aspartyl residues in the scrapie associated form of prion protein.
Topics: Animals; Asparagine; Aspartic Acid; Cricetinae; Isomerism; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; Protein Processing, Post-Translational; PrPSc Proteins; Scrapie | 1998 |
His...Asp catalytic dyad of ribonuclease A: structure and function of the wild-type, D121N, and D121A enzymes.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Cattle; Crystallography, X-Ray; Histidine; Hydrogen-Ion Concentration; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Secondary; Ribonuclease, Pancreatic; Structure-Activity Relationship | 1998 |
Identification of the catalytic triad of the protein D2 protease in Pseudomonas aeruginosa.
Topics: Alanine; Amino Acid Substitution; Asparagine; Aspartic Acid; Carbapenems; Catalysis; Endopeptidases; Glutamine; Histidine; Imipenem; Ion Channels; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Porins; Pseudomonas aeruginosa; Serine | 1998 |
Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect.
Topics: Asparagine; Aspartic Acid; Camphor 5-Monooxygenase; Catalysis; Crystallography, X-Ray; Deuterium Oxide; Electron Transport; Freezing; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Protons; Solvents | 1998 |
Partitioning of free energy gain between the photoisomerized retinal and the protein in bacteriorhodopsin.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Bacterial Proteins; Bacteriorhodopsins; Cysteine; Energy Transfer; Halobacterium salinarum; Hydrogen-Ion Concentration; Isomerism; Mutagenesis, Site-Directed; Phenylalanine; Photochemistry; Retinaldehyde; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman | 1998 |
Three-dimensional structures of mutant forms of E. coli inorganic pyrophosphatase with Asp-->Asn single substitution in positions 42, 65, 70, and 97.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Escherichia coli; Inorganic Pyrophosphatase; Protein Conformation; Pyrophosphatases; X-Ray Diffraction | 1998 |
Glu78, from the conserved PEWY sequence of subunit IV, has a key function in cytochrome b6f turnover.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Chlamydomonas reinhardtii; Chloroplasts; Conserved Sequence; Cytochrome b Group; Cytochrome b6f Complex; Electron Transport; Glutamic Acid; Glutamine; Kinetics; Leucine; Lysine; Mutagenesis, Site-Directed; Oxidation-Reduction; Peptide Fragments; Transformation, Genetic | 1998 |
Electrophilic assistance by Asp-99 of 3-oxo-Delta 5-steroid isomerase.
Topics: Alanine; Amino Acid Substitution; Asparagine; Aspartic Acid; Electrophoresis; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Pseudomonas; Steroid Isomerases | 1998 |
Purification and characterization of recombinant rabbit cytosolic serine hydroxymethyltransferase.
Topics: Animals; Asparagine; Aspartic Acid; Cloning, Molecular; Cytosol; Escherichia coli; Glycine Hydroxymethyltransferase; Isoelectric Focusing; Isomerism; Kinetics; Pyridoxal Phosphate; Rabbits; Recombinant Proteins; Serine; Spectrophotometry; Tetrahydrofolates | 1998 |
Solution structure of the N-terminal EGF-like domain from human factor VII.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Cattle; Crystallography, X-Ray; Epidermal Growth Factor; Factor VII; Humans; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Solutions | 1998 |
Cryocrystallography and microspectrophotometry of a mutant (alpha D60N) tryptophan synthase alpha 2 beta 2 complex reveals allosteric roles of alpha Asp60.
Topics: Allosteric Regulation; Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Catalysis; Crystallization; Crystallography, X-Ray; Freezing; Imines; Indoles; Microspectrophotometry; Models, Molecular; Molecular Sequence Data; Mutagenesis; Protein Binding; Protein Structure, Secondary; Serine; Tryptophan Synthase | 1998 |
Preserved catalytic activity in an engineered ribonucleotide reductase R2 protein with a nonphysiological radical transfer pathway. The importance of hydrogen bond connections between the participating residues.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Catalysis; Escherichia coli; Free Radicals; Glutamic Acid; Hydrogen Bonding; Iron; Protein Binding; Protein Engineering; Ribonucleotide Reductases; Tyrosine | 1998 |
Kinetic mechanism of Escherichia coli asparagine synthetase B.
Topics: Adenosine Monophosphate; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Bacterial Proteins; Binding, Competitive; Escherichia coli; Glutamine; Isotope Labeling; Kinetics; Oxygen Isotopes; Substrate Specificity | 1998 |
D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Topics: Asparagine; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Escherichia coli; Fluorodeoxyuridylate; Folic Acid; Hydrogen Bonding; Imidazoles; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Quinazolines; Substrate Specificity; Tetrahydrofolates; Thymidylate Synthase | 1998 |
Hb Nancy and Hb Osler: two distinct genetic variants with identical clinical and hemoglobin phenotype.
Topics: Asparagine; Aspartic Acid; Base Sequence; Black People; Codon; France; Globins; Hemoglobins, Abnormal; Humans; Phenotype; Polymerase Chain Reaction; Tyrosine; United States; White People | 1998 |
Oxygenic photosystem II: the mutation D1-D61N in Synechocystis sp. PCC 6803 retards S-state transitions without affecting electron transfer from YZ to P680+.
Topics: Asparagine; Aspartic Acid; Chlorophyll; Cyanobacteria; Electron Transport; Light; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxygen; Photosynthetic Reaction Center Complex Proteins; Polarography; Spectrophotometry; Tyrosine | 1998 |
A surface of Escherichia coli sigma 70 required for promoter function and antitermination by phage lambda Q protein.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Bacteriophage lambda; Base Sequence; DNA-Directed RNA Polymerases; Escherichia coli; Leucine; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Mutagenesis; Peptide Chain Termination, Translational; Phenylalanine; Promoter Regions, Genetic; Protein Binding; Sigma Factor; Transcription, Genetic; Viral Proteins | 1998 |
Ca2+ in the first epidermal growth factor-like domain of activated factor VII.
Topics: Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Calcium; Epidermal Growth Factor; Factor VIIa; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Structure, Tertiary | 1998 |
Activating a zymogen without proteolytic processing: mutation of Lys15 and Asn194 activates trypsinogen.
Topics: Animals; Aprotinin; Asparagine; Aspartic Acid; Cattle; Coumarins; Enzyme Activation; Enzyme Stability; Histidine; Hydrolysis; Lysine; Mutagenesis, Site-Directed; Oligopeptides; Peptide Fragments; Phenylalanine; Protein Conformation; Protein Processing, Post-Translational; Rats; Recombinant Fusion Proteins; Substrate Specificity; Trypsin; Trypsinogen | 1998 |
Schizosaccharomyces pombe rad32 protein: a phosphoprotein with an essential phosphoesterase motif required for repair of DNA double strand breaks.
Topics: Adenosine Triphosphatases; Alleles; Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Chromatography, Gel; DNA Damage; DNA Helicases; DNA Repair; Esterases; Exodeoxyribonucleases; Fungal Proteins; G2 Phase; Hydroxyurea; Iron; Meiosis; Methyl Methanesulfonate; Molecular Sequence Data; Molecular Weight; Mutagenesis; Phosphoproteins; Phosphorylation; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Spores, Fungal | 1998 |
Structural basis for inactivating mutations and pH-dependent activity of avian sarcoma virus integrase.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Avian Sarcoma Viruses; Binding Sites; Catalytic Domain; Cations, Divalent; Hydrogen Bonding; Hydrogen-Ion Concentration; Integrases; Molecular Sequence Data; Mutation; Protein Binding; Protein Conformation | 1998 |
Altering the purine specificity of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus by structure-based point mutations in the enzyme protein.
Topics: Adenine Phosphoribosyltransferase; Amino Acid Substitution; Animals; Arginine; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Enzyme Activation; Glutamic Acid; Guanine; Guanosine Monophosphate; Humans; Hypoxanthine Phosphoribosyltransferase; Isoleucine; Lysine; Mutagenesis, Site-Directed; Phenylalanine; Point Mutation; Purines; Ribonucleotides; Serine; Structure-Activity Relationship; Substrate Specificity; Tritrichomonas foetus; Tyrosine; Xanthine | 1998 |
A novel mutation in the D3 domain of von Willebrand factor markedly decreases its ability to bind factor VIII and affects its multimerization.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Base Sequence; DNA Mutational Analysis; Electrophoresis, Polyacrylamide Gel; Factor VIII; Heterozygote; Humans; Leukocytes; Male; Middle Aged; Mutation; Protein Binding; Protein Structure, Tertiary; von Willebrand Diseases; von Willebrand Factor | 1998 |
Double mutant cycle analysis of aspartate 69, 97, and 103 to asparagine mutants in the m2 muscarinic acetylcholine receptor.
Topics: Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; CHO Cells; Cricetinae; DNA Mutational Analysis; Gene Expression; Hot Temperature; Mice; Mutagenesis, Site-Directed; Protein Binding; Receptor, Muscarinic M2; Receptors, Muscarinic | 1999 |
Thermodynamic analysis of alpha-spectrin SH3 and two of its circular permutants with different loop lengths: discerning the reasons for rapid folding in proteins.
Topics: Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Calorimetry, Differential Scanning; Computer Simulation; Crystallization; Crystallography, X-Ray; Kinetics; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Folding; Spectrin; src Homology Domains; Temperature; Thermodynamics | 1999 |
Electron transfer between QA and QB in photosystem II is thermodynamically perturbed in phototolerant mutants of Synechocystis sp. PCC 6803.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Cyanobacteria; Electron Transport; Light; Molecular Sequence Data; Mutagenesis, Insertional; Mutagenesis, Site-Directed; Phenylalanine; Photosynthetic Reaction Center Complex Proteins; Photosystem II Protein Complex; Plastoquinone; Serine; Thermodynamics; Thermoluminescent Dosimetry | 1999 |
Calcium binding to the class I alpha-1,2-mannosidase from Saccharomyces cerevisiae occurs outside the EF hand motif.
Topics: Asparagine; Aspartic Acid; Binding Sites; Calcium; Calcium-Binding Proteins; Catalysis; Enzyme Stability; Glutamic Acid; Glutamine; Hot Temperature; Kinetics; Mannosidases; Mutagenesis, Site-Directed; Peptide Fragments; Recombinant Proteins; Saccharomyces cerevisiae | 1999 |
Substitution of Asp-309 by Asn in the Arg-Asp-Pro (RDP) motif of Acetobacter diazotrophicus levansucrase affects sucrose hydrolysis, but not enzyme specificity.
Topics: Acetobacter; Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Conserved Sequence; Hexosyltransferases; Hydrolysis; Mutagenesis, Site-Directed; Sucrose | 1999 |
Posttranslational deamidation of proteins: the case of hemoglobin J Sardegna [alpha50(CD8)His-->Asn-->Asp].
Topics: Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; DNA; Electrophoresis, Cellulose Acetate; Hemoglobin J; Histidine; Humans; Isoelectric Focusing; Point Mutation; Protein Processing, Post-Translational; Sequence Analysis, DNA | 1999 |
Is glutamine a pretender to the throne?
Topics: Arginine; Asparagine; Aspartic Acid; Dipeptides; Glutamic Acid; Glutamine; Humans; Parenteral Nutrition, Total | 1999 |
Thiamin-binding protein from sunflower seeds.
Topics: Asparagine; Aspartic Acid; Carrier Proteins; Chromatography, Gel; Glutamic Acid; Glutamine; Helianthus; Hydrogen-Ion Concentration; Molecular Weight; Seeds; Thiamine | 1998 |
Engineered human carboxypeptidase B enzymes that hydrolyse hippuryl-L-glutamic acid: reversed-polarity mutants.
Topics: Alanine; Asparagine; Aspartic Acid; Carboxypeptidase B; Carboxypeptidases; Escherichia coli; Gene Expression; Humans; Hydrolysis; Kinetics; Molecular Structure; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Structure-Activity Relationship; Substrate Specificity | 1998 |
Arginine activity in the proton-motive photocycle of bacteriorhodopsin: solid-state NMR studies of the wild-type and D85N proteins.
Topics: Amino Acid Substitution; Arginine; Asparagine; Aspartic Acid; Bacteriorhodopsins; Carbon Isotopes; Crystallography, X-Ray; Halobacterium salinarum; Magnetic Resonance Spectroscopy; Photochemistry; Proton-Motive Force | 1999 |
Posttranslational modification of Galphao1 generates Galphao3, an abundant G protein in brain.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Binding Sites; Brain; Cattle; Chromatography, High Pressure Liquid; Cloning, Molecular; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Mass Spectrometry; Molecular Sequence Data; Peptide Fragments; Protein Isoforms; Protein Processing, Post-Translational; Rats; Recombinant Proteins; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transcription, Genetic; Trypsin | 1999 |
Probing the binding of coumarins and cyclothialidines to DNA gyrase.
Topics: Adenosine Triphosphate; Arginine; Asparagine; Aspartic Acid; Binding Sites; Coumarins; DNA Topoisomerases, Type II; Enzyme Inhibitors; Hydrolysis; Kinetics; Mutagenesis, Site-Directed; Peptides, Cyclic; Surface Plasmon Resonance; Topoisomerase II Inhibitors; Trypsin | 1999 |
A natural grouping of motifs with an aspartate or asparagine residue forming two hydrogen bonds to residues ahead in sequence: their occurrence at alpha-helical N termini and in other situations.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Aspartic Acid Endopeptidases; Carrier Proteins; Citrate (si)-Synthase; Conserved Sequence; Databases, Factual; Glutathione Reductase; Hemoglobins; Hydrogen Bonding; Hydrolases; Lipocalin 1; Models, Molecular; Protein Structure, Secondary; Proteins; Troponin C | 1999 |
The contribution of acidic residues to the conformational stability of common-type acylphosphatase.
Topics: Acid Anhydride Hydrolases; Acylphosphatase; Amino Acid Substitution; Asparagine; Aspartic Acid; Enzyme Stability; Glutamic Acid; Glutamine; Humans; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Fusion Proteins; Substrate Specificity | 1999 |
Distortion of the L-->M transition in the photocycle of the bacteriorhodopsin mutant D96N: a time-resolved step-scan FTIR investigation.
Topics: Asparagine; Aspartic Acid; Bacteriorhodopsins; Mutagenesis, Site-Directed; Spectroscopy, Fourier Transform Infrared; Time Factors | 1999 |
Hydrogen bonds between short polar side chains and peptide backbone: prevalence in proteins and effects on helix-forming propensities.
Topics: Asparagine; Aspartic Acid; Glutamine; Hydrogen Bonding; Kinetics; Protein Structure, Secondary; Serine; Threonine | 1999 |
Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications.
Topics: Animals; Asparagine; Aspartic Acid; COS Cells; Humans; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Receptors, Neurokinin-2; Recombinant Proteins; Xenopus | 1999 |
Mutations of aspartate 103 in the Hm2 receptor and alterations in receptor binding properties of muscarinic agonists.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Alanine; Amino Acid Substitution; Animals; Arecoline; Asparagine; Aspartic Acid; Carbachol; COS Cells; Muscarinic Agonists; Mutagenesis, Site-Directed; Oxotremorine; Pilocarpine; Receptor, Muscarinic M2; Receptors, Muscarinic; Transfection | 1995 |
Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Base Sequence; Cells, Cultured; Cloning, Molecular; DNA Primers; DNA, Complementary; Humans; Interleukin-1 Receptor-Associated Kinases; Molecular Sequence Data; NF-kappa B; Phosphorylation; Protein Kinases; Sequence Homology, Amino Acid; Spodoptera; Transcription, Genetic | 1999 |
Product catalyzes the deamidation of D145N dehalogenase to produce the wild-type enzyme.
Topics: Amides; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Hydrolases; Models, Chemical; Mutagenesis, Site-Directed; Pseudomonas; Spectrum Analysis, Raman; Substrate Specificity; Time Factors | 1999 |
Intermediate spectra and photocycle kinetics of the Asp96 --> asn mutant bacteriorhodopsin determined by singular value decomposition with self-modeling.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Bacteriorhodopsins; Halobacterium salinarum; Kinetics; Models, Chemical; Mutagenesis, Site-Directed; Recombinant Proteins | 1999 |
Functional role of the spatial proximity of Asp114(2.50) in TMH 2 and Asn332(7.49) in TMH 7 of the mu opioid receptor.
Topics: Animals; Asparagine; Aspartic Acid; Binding Sites; CHO Cells; Cricetinae; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Mutagenesis, Site-Directed; Naloxone; Peptide Fragments; Peptides; Protein Structure, Secondary; Rats; Receptors, Opioid, mu; Somatostatin; Transfection | 1999 |
Protein side-chain conformation: a systematic variation of chi 1 mean values with resolution - a consequence of multiple rotameric states?
Topics: Asparagine; Aspartic Acid; Crystallography, X-Ray; Cysteine; Protein Conformation; Proteins; Rotation; Solubility; Solvents | 1999 |
Active sites of diacylglycerol kinase from Escherichia coli are shared between subunits.
Topics: Alanine; Asparagine; Aspartic Acid; Binding Sites; Circular Dichroism; Diacylglycerol Kinase; Enzyme Activation; Escherichia coli; Genetic Complementation Test; Glutamine; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Serine; Structure-Activity Relationship | 1999 |
Aspartate-132 in cytochrome c oxidase from Rhodobacter sphaeroides is involved in a two-step proton transfer during oxo-ferryl formation.
Topics: Amino Acid Substitution; Arachidonic Acid; Asparagine; Aspartic Acid; Carbon Monoxide; Electrochemistry; Electron Transport; Electron Transport Complex IV; Iron; Oxidation-Reduction; Proton Pumps; Protons; Rhodobacter sphaeroides | 1999 |
Functional roles of aspartic acid residues at the cytoplasmic surface of bacteriorhodopsin.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Bacteriorhodopsins; Biological Transport; Conserved Sequence; Cytoplasm; Halobacterium salinarum; Hydrogen-Ion Concentration; Light; Molecular Sequence Data; Mutagenesis, Site-Directed; Photolysis; Protons; Purple Membrane | 1999 |
Measurement of urinary amino acids using high-performance liquid chromatography equipped with a strong cation exchange resin pre-column.
Topics: Amino Acids; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Glutamic Acid; Glutamine; Humans; Reproducibility of Results | 1999 |
Aspartic acid for asparagine substitution at position 276 reduces susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 beta-lactamases.
Topics: Amino Acid Substitution; Anti-Bacterial Agents; Asparagine; Aspartic Acid; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Clavulanic Acid; Enzyme Inhibitors; Escherichia coli; Inhibitory Concentration 50; Microbial Sensitivity Tests; Penicillanic Acid; Sulbactam; Tazobactam | 1999 |
An unexpected role for the active site base in cofactor orientation and flexibility in the copper amine oxidase from Hansenula polymorpha.
Topics: Amine Oxidase (Copper-Containing); Ammonia; Asparagine; Aspartic Acid; Binding Sites; Carbon; Deuterium; Enzyme Activation; Glutamic Acid; Hydrogen; Methylamines; Mutagenesis, Site-Directed; Oxygen; Pichia; Schiff Bases; Solvents; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Substrate Specificity; Viscosity | 1999 |
The active site base controls cofactor reactivity in Escherichia coli amine oxidase: x-ray crystallographic studies with mutational variants.
Topics: Amine Oxidase (Copper-Containing); Asparagine; Aspartic Acid; Binding Sites; Crystallization; Crystallography, X-Ray; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Glutamic Acid; Kinetics; Mass Spectrometry; Metals; Models, Molecular; Mutagenesis, Site-Directed; Pyridones; Spectrophotometry, Ultraviolet | 1999 |
Effects of substitutions of lysine and aspartic acid for asparagine at beta 108 and of tryptophan for valine at alpha 96 on the structural and functional properties of human normal adult hemoglobin: roles of alpha 1 beta 1 and alpha 1 beta 2 subunit inter
Topics: 2,3-Diphosphoglycerate; Adult; Amino Acid Substitution; Asparagine; Aspartic Acid; Buffers; Chlorides; Hemoglobin A; Hemoglobins; Hemoglobins, Abnormal; HEPES; Humans; Lysine; Nuclear Magnetic Resonance, Biomolecular; Oxygen; Oxyhemoglobins; Phosphates; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Structure-Activity Relationship; Tryptophan; Valine | 1999 |
Chromophore-protein-water interactions in the L intermediate of bacteriorhodopsin: FTIR study of the photoreaction of L at 80 K.
Topics: Alanine; Amino Acid Substitution; Asparagine; Aspartic Acid; Bacteriorhodopsins; Cold Temperature; Halobacterium salinarum; Hydrogen; Models, Molecular; Oxygen; Photochemistry; Schiff Bases; Spectroscopy, Fourier Transform Infrared; Threonine; Tryptophan; Valine; Water | 1999 |
Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin.
Topics: Amides; Animals; Arginine; Asparagine; Aspartic Acid; Binding Sites; Cholecystokinin; Computer Simulation; COS Cells; Humans; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Type C Phospholipases | 1999 |
Inhibition of glutamine transport in rat brain mitochondria by some amino acids and tricarboxylic acid cycle intermediates.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Biological Transport; Brain; Citric Acid Cycle; Glutamic Acid; Glutamine; Ketoglutaric Acids; Kinetics; Malates; Mitochondria; Rats; Rats, Wistar; Succinic Acid | 1999 |
X-ray structure of the Asn276Asp variant of the Escherichia coli TEM-1 beta-lactamase: direct observation of electrostatic modulation in resistance to inactivation by clavulanic acid.
Topics: Asparagine; Aspartic Acid; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; Clavulanic Acid; Crystallography, X-Ray; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Recombinant Proteins; Static Electricity | 1999 |
Construction and characterization of mutants of the TEM-1 beta-lactamase containing amino acid substitutions associated with both extended-spectrum resistance and resistance to beta-lactamase inhibitors.
Topics: Amino Acid Substitution; Arginine; Asparagine; Aspartic Acid; beta-Lactamase Inhibitors; beta-Lactamases; Cephalosporin Resistance; Cysteine; Enzyme Inhibitors; Leucine; Methionine; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Penicillin Resistance; Phenotype | 1999 |
Relocation of the catalytic carboxylate group in class A beta-lactamase: the structure and function of the mutant enzyme Glu166-->Gln:Asn170-->Asp.
Topics: Acylation; Anti-Bacterial Agents; Asparagine; Aspartic Acid; beta-Lactamases; beta-Lactams; Catalytic Domain; Crystallography, X-Ray; Glutamic Acid; Glutamine; Kinetics; Models, Molecular; Mutation; Protein Conformation; Staphylococcus aureus; Structure-Activity Relationship | 1999 |
Spontaneous deamidation and isomerization of Asn108 in prion peptide 106-126 and in full-length prion protein.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Cricetinae; Humans; Isomerism; Kinetics; Mass Spectrometry; Metalloendopeptidases; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Prions; Protein Conformation; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; PrPC Proteins; PrPSc Proteins; Trypsin | 1999 |
The Hb Tarrant [alpha126(H9)Asp-->Asn]] mutation is localized in the alpha2-globin gene.
Topics: Asparagine; Aspartic Acid; Globins; Hematologic Tests; Hemoglobins, Abnormal; Humans; Male; Mexico; Point Mutation; Sequence Analysis, DNA | 1999 |
Role of electrophilic and general base catalysis in the mechanism of Escherichia coli uracil DNA glycosylase.
Topics: Asparagine; Aspartic Acid; Binding Sites; Catalysis; Deuterium Oxide; DNA Glycosylases; Escherichia coli; Glutamine; Histidine; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mutagenesis, Site-Directed; N-Glycosyl Hydrolases; Solvents; Substrate Specificity; Uracil; Uracil-DNA Glycosidase | 1999 |
Intersegment hydrogen bonds as possible structural determinants of the N/Q/R site in glutamate receptors.
Topics: Arginine; Asparagine; Aspartic Acid; Binding Sites; Calcium; Excitatory Amino Acid Antagonists; Glutamine; Hydrogen Bonding; Kinetics; Models, Molecular; Monte Carlo Method; Oxygen; Protein Conformation; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Static Electricity | 1999 |
Atomic resolution structures of the core domain of avian sarcoma virus integrase and its D64N mutant.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Avian Sarcoma Viruses; Binding Sites; Computer Simulation; Crystallography, X-Ray; Hydrogen Bonding; Hydrogen-Ion Concentration; Integrases; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Point Mutation; Protein Conformation; Protein Structure, Tertiary; Solvents; Thermodynamics | 1999 |
Buried, charged, non-ion-paired aspartic acid 76 contributes favorably to the conformational stability of ribonuclease T1.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Enzyme Stability; Hydrogen-Ion Concentration; Ions; Models, Chemical; Point Mutation; Protein Conformation; Protein Denaturation; Ribonuclease T1; Serine; Static Electricity | 1999 |
Both ATP sites of human P-glycoprotein are essential but not symmetric.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Motifs; Amino Acid Substitution; Antibodies, Monoclonal; Asparagine; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Biological Transport; Body Temperature; Cell Membrane; Consensus Sequence; Enzyme Activation; Freezing; HeLa Cells; Humans; Peptide Fragments; Phosphorus Radioisotopes; Photoaffinity Labels; Point Mutation; Prazosin; Protein Conformation; Recombinant Fusion Proteins; Vanadates; Verapamil | 1999 |
Glutamate-containing parenteral nutrition doubles plasma glutamate: a risk factor in neurosurgical patients with blood-brain barrier damage?
Topics: Asparagine; Aspartic Acid; Blood-Brain Barrier; Brain Edema; Chromatography, High Pressure Liquid; Craniotomy; Female; Glutamic Acid; Glutamine; Hospitals, University; Humans; Intensive Care Units; Male; Middle Aged; Parenteral Nutrition; Prospective Studies; Risk Factors; Treatment Outcome | 1999 |
Design of an adenosine phosphorylase by active-site modification of murine purine nucleoside phosphorylase. Enzyme kinetics and molecular dynamics simulation of Asn-243 and Lys-244 substitutions of purine nucleoside phosphorylase.
Topics: Allosteric Regulation; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Catalytic Domain; Computer Simulation; Formycins; Glutamine; Kinetics; Lysine; Mice; Models, Molecular; Purine-Nucleoside Phosphorylase; Substrate Specificity | 1999 |
Deamidation of asparagine residues in a recombinant serine hydroxymethyltransferase.
Topics: Amides; Animals; Asparagine; Aspartic Acid; Catalysis; Enzyme Stability; Escherichia coli; Glycine Hydroxymethyltransferase; Humans; Isoelectric Point; Kinetics; Liver; Mutagenesis, Site-Directed; Mutation; Rabbits; Recombinant Proteins; Serine; Structure-Activity Relationship; Tetrahydrofolates | 1999 |
Carbonyl-carbonyl interactions stabilize the partially allowed Ramachandran conformations of asparagine and aspartic acid.
Topics: Amino Acids; Asparagine; Aspartic Acid; Crystallography, X-Ray; Models, Molecular; Molecular Conformation; Protein Structure, Secondary | 1999 |
Mutational analysis of the primary substrate specificity pocket of complement factor B. Asp(226) is a major structural determinant for p(1)-Arg binding.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Catalytic Domain; Complement C3-C5 Convertases; Complement Factor B; Complement Factor D; Elapid Venoms; Hemolysis; Models, Molecular; Molecular Sequence Data; Mutation; Sequence Homology, Amino Acid; Substrate Specificity | 2000 |
An Asp79Asn mutation of the alpha2A-adrenoceptor interferes equally with agonist activation of individual Gialpha-family G protein subtypes.
Topics: Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Cell Membrane; COS Cells; Epinephrine; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Kinetics; Mutation; Point Mutation; Protein Binding; Proto-Oncogene Proteins; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Swine | 1999 |
Mechanisms regulating the cell surface residence time of the alpha 2A-adrenergic receptor.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Asparagine; Aspartic Acid; Binding Sites; Cell Membrane; CHO Cells; Cricetinae; GTP-Binding Proteins; Half-Life; Kinetics; Ligands; Receptors, Adrenergic, alpha-2; Time Factors; Transfection; Up-Regulation | 2000 |
Asp-99 donates a hydrogen bond not to Tyr-14 but to the steroid directly in the catalytic mechanism of Delta 5-3-ketosteroid isomerase from Pseudomonas putida biotype B.
Topics: Asparagine; Aspartic Acid; Binding Sites; Catalysis; Equilenin; Glutamic Acid; Hydrogen Bonding; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; Nandrolone; Pseudomonas putida; Steroid Isomerases; Tyrosine | 2000 |
Presence of 2-furoylmethyl derivatives in hydrolysates of processed tomato products.
Topics: Alanine; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Freeze Drying; Furans; gamma-Aminobutyric Acid; Glutamic Acid; Hydrolysis; Lysine; Maillard Reaction; Serine; Solanum lycopersicum; Threonine | 2000 |
Substitution of asparagine for aspartic acid at residue 9 (D9N) of lipoprotein lipase markedly augments risk of ischaemic heart disease in male smokers.
Topics: Asparagine; Aspartic Acid; Confidence Intervals; Genotype; Heterozygote; Humans; Lipoprotein Lipase; Male; Middle Aged; Myocardial Ischemia; Population Surveillance; Proportional Hazards Models; Prospective Studies; Reference Values; Risk Assessment; Smoking | 2000 |
Site-directed mutagenesis identifies residues in uncoupling protein (UCP1) involved in three different functions.
Topics: Adipose Tissue, Brown; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Binding Sites; Carrier Proteins; Chlorides; Cricetinae; Electron Transport; Glutamic Acid; Glutamine; Guanosine Triphosphate; Ion Channels; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Mutagenesis, Site-Directed; Protons; Saccharomyces cerevisiae; Uncoupling Agents; Uncoupling Protein 1 | 2000 |
Investigation of spectroscopic intermediates during copper-binding and TPQ formation in wild-type and active-site mutants of a copper-containing amine oxidase from yeast.
Topics: Amine Oxidase (Copper-Containing); Asparagine; Aspartic Acid; Binding Sites; Coenzymes; Copper; Cysteine; Dihydroxyphenylalanine; Glutamic Acid; Glutamine; Histidine; Mutagenesis, Site-Directed; Oxygen Consumption; Pichia; Recombinant Proteins; Spectrophotometry, Atomic; Spectrophotometry, Ultraviolet | 2000 |
Mechanism of Ca2+-induced inhibition of Escherichia coli inorganic pyrophosphatase.
Topics: Alanine; Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Calcium; Dialysis; Diphosphates; Escherichia coli; Glutamic Acid; Hydrolysis; Inorganic Pyrophosphatase; Kinetics; Lanthanum; Magnesium Compounds; Models, Molecular; Pyrophosphatases | 2000 |
Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
Topics: Animals; Asparagine; Aspartic Acid; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Kinetics; Membrane Proteins; Mice; Mice, Knockout; Models, Molecular; Molecular Conformation; Molecular Weight; ortho-Aminobenzoates; Oxalates; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; src Homology Domains | 2000 |
Mutation of Asn-391 within the conserved NPXXY motif of the cholecystokinin B receptor abolishes Gq protein activation without affecting its association with the receptor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Binding Sites; Cholecystokinin; Conserved Sequence; COS Cells; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Peptide Fragments; Protein Kinase C; Rats; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Recombinant Proteins; Transfection; Type C Phospholipases | 2000 |
Deterministic features of side-chain main-chain hydrogen bonds in globular protein structures.
Topics: Amino Acids; Asparagine; Aspartic Acid; Crystallization; Glutamic Acid; Glutamine; Histidine; Hydrogen Bonding; Protein Conformation; Protein Structure, Secondary; Proteins; Serine; Threonine | 2000 |
Modeling the effects of mutations on the free energy of the first electron transfer from QA- to QB in photosynthetic reaction centers.
Topics: Alanine; Arginine; Asparagine; Aspartic Acid; Electron Transport; Energy Transfer; Glutamic Acid; Glutamine; Leucine; Models, Chemical; Mutagenesis, Site-Directed; Photosynthetic Reaction Center Complex Proteins; Quinones; Rhodobacter capsulatus; Rhodobacter sphaeroides; Static Electricity; Thermodynamics; Water | 2000 |
High-affinity binding to the GM-CSF receptor requires intact N-glycosylation sites in the extracellular domain of the beta subunit.
Topics: Alanine; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Binding Sites; Cell Membrane; Cloning, Molecular; COS Cells; Glycosylation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recombinant Proteins; Transfection | 2000 |
Murine aspartoacylase: cloning, expression and comparison with the human enzyme.
Topics: Acetylation; Amides; Amidohydrolases; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Canavan Disease; Chromatography, Affinity; Cloning, Molecular; Humans; Hydrolysis; Mice; Molecular Sequence Data; Recombinant Fusion Proteins; Sequence Alignment; Substrate Specificity | 2000 |
Characterization of beta-galactosidase mutations Asp332-->Asn and Arg148-->Ser, and a polymorphism, Ser532-->Gly, in a case of GM1 gangliosidosis.
Topics: Amino Acid Substitution; Animals; Arginine; Asparagine; Aspartic Acid; Base Sequence; beta-Galactosidase; CHO Cells; COS Cells; Cricetinae; DNA Primers; Fluorescent Antibody Technique; Gangliosidosis, GM1; Glycine; Humans; Mutation, Missense; Serine | 2000 |
Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Bacillus; Binding Sites; Catalysis; Crystallography, X-Ray; Disaccharides; Glutamic Acid; Glycoside Hydrolases; Glycosylation; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Mass Spectrometry; Models, Chemical; Models, Molecular; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protons; Static Electricity; Structure-Activity Relationship; Xylan Endo-1,3-beta-Xylosidase; Xylosidases | 2000 |
Distribution of Q188R and N314D mutations in the Hungarian galactosemic population.
Topics: Amino Acid Substitution; Arginine; Asparagine; Aspartic Acid; Galactosemias; Gene Frequency; Genetic Carrier Screening; Genetics, Population; Glutamine; Humans; Hungary; Infant, Newborn; Neonatal Screening | 2000 |
Effect of hypertrophic cardiomyopathy mutations in human cardiac muscle alpha -tropomyosin (Asp175Asn and Glu180Gly) on the regulatory properties of human cardiac troponin determined by in vitro motility assay.
Topics: Animals; Asparagine; Aspartic Acid; Calcium; Cardiomegaly; Cardiomyopathies; Cell Movement; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; Heart; Humans; Microscopy, Fluorescence; Muscle Fibers, Fast-Twitch; Muscle, Skeletal; Mutagenesis; Myocardium; Rabbits; Recombinant Proteins; Tropomyosin; Troponin | 2000 |
Glutamine metabolism in endothelial cells: ornithine synthesis from glutamine via pyrroline-5-carboxylate synthase.
Topics: Alanine; Ammonia; Animals; Antimetabolites, Antineoplastic; Aorta; Asparagine; Aspartic Acid; Azaserine; Carbon Dioxide; Cattle; Cells, Cultured; Diazooxonorleucine; Endothelium, Vascular; Enzymes; Glutamic Acid; Glutamine; Humans; Microcirculation; Ornithine; Ornithine-Oxo-Acid Transaminase; Umbilical Veins; Venules | 2000 |
A new class of glutamate dehydrogenases (GDH). Biochemical and genetic characterization of the first member, the AMP-requiring NAD-specific GDH of Streptomyces clavuligerus.
Topics: Adenosine Monophosphate; Allosteric Site; Amino Acid Sequence; Ammonia; Asparagine; Aspartic Acid; Base Sequence; Carbon; Catalysis; Cell Division; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Evolution, Molecular; Glutamate Dehydrogenase; Glycerol; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kinetics; Molecular Sequence Data; Molecular Weight; NAD; Nitrogen; Phylogeny; Polymerase Chain Reaction; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Streptomyces; Temperature; Time Factors; Tricarboxylic Acids | 2000 |
Two clusters of acidic amino acids near the NH2 terminus of complement component C4 alpha'-chain are important for C2 binding.
Topics: Amino Acid Sequence; Amino Acids; Animals; Antibodies, Blocking; Asparagine; Aspartic Acid; Binding Sites, Antibody; Complement C2; Complement C4; COS Cells; Glutamic Acid; Glutamine; Humans; Molecular Mimicry; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Protein Binding | 2000 |
Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu.
Topics: Alanine; Animals; Anti-HIV Agents; Arginine; Asparagine; Aspartic Acid; Binding Sites; Chemotaxis; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enfuvirtide; Guanosine 5'-O-(3-Thiotriphosphate); HIV Envelope Protein gp41; Humans; Kinetics; Leucine; Ligands; Methionine; Models, Chemical; Mutagenesis, Site-Directed; Mutation; Peptide Biosynthesis; Peptide Fragments; Phenylalanine; Protein Binding; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Sodium; Tryptophan | 2000 |
The Na+/Ca2+ exchanger NCX1 has oppositely oriented reentrant loop domains that contain conserved aspartic acids whose mutation alters its apparent Ca2+ affinity.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Binding Sites; Calcium; Cattle; Cell Membrane; Conserved Sequence; Cricetinae; Cysteine; Dogs; Membrane Potentials; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Rats; Recombinant Proteins; Repetitive Sequences, Amino Acid; Sequence Alignment; Sequence Homology, Amino Acid; Sodium; Sodium-Calcium Exchanger; Transfection | 2000 |
Directed molecular evolution of cytochrome c peroxidase.
Topics: Alanine; Asparagine; Aspartic Acid; Cloning, Molecular; Cytochrome-c Peroxidase; Directed Molecular Evolution; Enzyme Activation; Gene Library; Genetic Vectors; Guaiacol; Point Mutation; Saccharomyces cerevisiae; Substrate Specificity; Threonine; Tyrosine | 2000 |
Mutational analysis of metallo-beta-lactamase CcrA from Bacteroides fragilis.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Bacterial Proteins; Bacteroides fragilis; beta-Lactamases; Cysteine; Deuterium; DNA Mutational Analysis; DNA, Bacterial; Gene Expression Regulation, Bacterial; Hydrogen-Ion Concentration; Kinetics; Metalloproteins; Mutagenesis, Site-Directed; Protons; Recombinant Proteins; Serine; Solvents; Zinc | 2000 |
Abolishment of proton pumping and accumulation in the E1P conformational state of a plant plasma membrane H+-ATPase by substitution of a conserved aspartyl residue in transmembrane segment 6.
Topics: Adenosine Triphosphatases; Arabidopsis; Asparagine; Aspartic Acid; Blotting, Western; Catalysis; Cell Membrane; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Ligands; Mutagenesis, Site-Directed; Phosphorylation; Plant Proteins; Protein Conformation; Proton-Translocating ATPases; Protons; Saccharomyces cerevisiae; Time Factors; Trypsin; Vanadates | 2000 |
Mutagenesis and kinetic studies of a plant cysteine proteinase with an unusual arrangement of acidic amino acids in and around the active site.
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Cloning, Molecular; Cysteine Endopeptidases; DNA, Complementary; Escherichia coli; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Magnoliopsida; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Plant Proteins; Protein Precursors; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship | 2000 |
Contribution of salt bridges near the surface of a protein to the conformational stability.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Calorimetry, Differential Scanning; Crystallization; Crystallography, X-Ray; Glutamic Acid; Glutamine; Hot Temperature; Humans; Hydrogen-Ion Concentration; Muramidase; Mutagenesis, Site-Directed; Potassium Chloride; Protein Conformation; Protein Denaturation; Salts; Surface Properties | 2000 |
DNA structure and aspartate 276 influence nucleotide binding to human DNA polymerase beta. Implication for the identity of the rate-limiting conformational change.
Topics: Asparagine; Aspartic Acid; Binding Sites; Deoxycytosine Nucleotides; DNA; DNA Polymerase beta; Humans; Models, Molecular; Nucleic Acid Conformation; Nucleotides; Protein Conformation | 2001 |
Tryptophan 67 in the human VPAC(1) receptor: crucial role for VIP binding.
Topics: Animals; Asparagine; Aspartic Acid; CHO Cells; COS Cells; Cricetinae; Cyclic AMP; Humans; Mutagenesis, Site-Directed; Protein Conformation; Receptors, Vasoactive Intestinal Peptide; Receptors, Vasoactive Intestinal Polypeptide, Type I; Transfection; Tryptophan; Vasoactive Intestinal Peptide | 2000 |
Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation.
Topics: Asparagine; Aspartic Acid; Blotting, Western; Catalysis; Cell Cycle Proteins; Cell Line; Cell Nucleus; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 1; Enzyme Activation; HeLa Cells; Humans; Immediate-Early Proteins; Intracellular Signaling Peptides and Proteins; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Phosphotransferases; Plasmids; Point Mutation; Protein Binding; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Recombinant Proteins; Signal Transduction; Time Factors; Transcription, Genetic; Transfection | 2000 |
A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling.
Topics: Analgesics, Opioid; Animals; Asparagine; Aspartic Acid; Cells, Cultured; COS Cells; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Mutagenesis, Site-Directed; Narcotics; Polymorphism, Single Nucleotide; Proline; Receptors, Opioid, mu; Serine; Signal Transduction; Sulfur Radioisotopes | 2001 |
Aspartate-187 of cytochrome b is not needed for DCCD inhibition of ubiquinol: cytochrome c oxidoreductase in Rhodobacter sphaeroides chromatophores.
Topics: Aerobiosis; Asparagine; Aspartic Acid; Chromatophores; Cytochrome b Group; Dicyclohexylcarbodiimide; Electrochemistry; Electron Transport; Electron Transport Complex IV; Kinetics; Oxidation-Reduction; Photolysis; Photosynthesis; Rhodobacter sphaeroides; Spectrophotometry; Ubiquinone | 2000 |
Alteration of conformation and dynamics of bacteriorhodopsin induced by protonation of Asp 85 and deprotonation of Schiff base as studied by 13C NMR.
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspartic Acid; Bacteriorhodopsins; Carbon Isotopes; Cytoplasm; Extracellular Space; Halobacterium salinarum; Hydrogen-Ion Concentration; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protons; Schiff Bases; Temperature; Thermodynamics; Valine | 2000 |
Role of the conserved acidic residue Asp21 in the structure of phosphatidylinositol 3-kinase Src homology 3 domain: circular dichroism and nuclear magnetic resonance studies.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Circular Dichroism; Conserved Sequence; Histidine; Humans; Kinetics; Ligands; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides; Phenylalanine; Phosphatidylinositol 3-Kinases; Protein Conformation; src Homology Domains; Tyrosine | 2001 |
Influence of myristoylation, phosphorylation, and deamidation on the structural behavior of the N-terminus of the catalytic subunit of cAMP-dependent protein kinase.
Topics: Acylation; Amides; Amino Acid Sequence; Asparagine; Aspartic Acid; Catalytic Domain; Circular Dichroism; Cyclic AMP-Dependent Protein Kinases; Isoenzymes; Molecular Sequence Data; Myristic Acid; Peptide Fragments; Phosphorylation; Protein Conformation; Protein Structure, Secondary | 2001 |
Probing the interactions between cAMP and cGMP in cyclic nucleotide-gated channels using covalently tethered ligands.
Topics: Allosteric Regulation; Animals; Asparagine; Aspartic Acid; Binding Sites; Cattle; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Eye Proteins; Ion Channels; Ligands; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Rod Cell Outer Segment; Xenopus laevis | 2001 |
Kinetic and thermodynamic control of the relative yield of the deamidation of asparagine and isomerization of aspartic acid residues.
Topics: Animals; Asparagine; Aspartic Acid; Cattle; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Isomerism; Kinetics; Models, Chemical; Pancreas; Ribonuclease, Pancreatic; Succinimides; Temperature; Thermodynamics; Time Factors | 2000 |
Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor.
Topics: Amino Acid Sequence; Animals; Anti-HIV Agents; Antiviral Agents; Asparagine; Aspartic Acid; Benzylamines; Binding, Competitive; Chemokine CXCL12; Chemokines, CXC; COS Cells; Cyclams; DNA, Complementary; Heterocyclic Compounds; Humans; Inhibitory Concentration 50; Kinetics; Ligands; Linear Models; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Receptors, CXCR4; Transfection | 2001 |
Probing the relative timing of hydrogen abstraction steps in the flavocytochrome b2 reaction with primary and solvent deuterium isotope effects and mutant enzymes.
Topics: Asparagine; Aspartic Acid; Binding Sites; Deuterium; Electron Transport; Flavins; Hydrogen Bonding; Kinetics; L-Lactate Dehydrogenase; L-Lactate Dehydrogenase (Cytochrome); Mutagenesis, Site-Directed; Protein Structure, Tertiary; Protons; Saccharomyces cerevisiae; Solvents | 2001 |
Poly(amino acid) bioadhesives for tissue repair.
Topics: Adhesiveness; Amino Acids; Animals; Asparagine; Aspartic Acid; Biocompatible Materials; Cartilage; Cattle; Chondroitin Sulfates; Glass; Glutamic Acid; Hydrogen Bonding; Lysine; Materials Testing; Models, Chemical; Models, Molecular; Permeability; Tissue Adhesions; Tissue Adhesives; Wound Healing; Wounds and Injuries | 2000 |
Hydrophobic analogues of the winter flounder 'antifreeze' protein.
Topics: Alanine; Amino Acid Substitution; Aminobutyrates; Animals; Antifreeze Proteins; Asparagine; Aspartic Acid; Flounder; Freezing; Ice; Isoleucine; Leucine; Protein Engineering; Protein Structure, Secondary; Structure-Activity Relationship; Threonine | 2001 |
Creutzfeldt-Jakob disease segregating in a three generation Danish family.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Alleles; Asparagine; Aspartic Acid; Creutzfeldt-Jakob Syndrome; Disease Progression; Electroencephalography; Female; Hippocampus; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Male; Middle Aged; Pedigree; Phenotype; Point Mutation; Polymorphism, Genetic; Prions | 2001 |
The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, and X-ray crystallography.
Topics: Alanine; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Crystallography, X-Ray; Enzyme Activation; Escherichia coli; Genetic Complementation Test; Glutamic Acid; Glutamine; Humans; Hydrogen-Ion Concentration; Hypoxanthine Phosphoribosyltransferase; Kinetics; Mutagenesis, Site-Directed; Plasmodium falciparum; Recombinant Proteins; Structure-Activity Relationship; Substrate Specificity | 2001 |
A helical turn motif in Mss4 is a critical determinant of Rab binding and nucleotide release.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Conserved Sequence; Evolution, Molecular; Guanine Nucleotide Exchange Factors; Guanosine Diphosphate; Helix-Turn-Helix Motifs; Kinetics; Mice; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Structure, Tertiary; Proteins; rab GTP-Binding Proteins; Rats; Sequence Homology, Amino Acid; Serine | 2001 |
The "catalytic" triad of isocitrate dehydrogenase kinase/phosphatase from E. coli and its relationship with that found in eukaryotic protein kinases.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Catalytic Domain; Escherichia coli; Eukaryotic Cells; Magnesium; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis, Site-Directed; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Sequence Alignment | 2001 |
Transition state analysis and requirement of Asp-262 general acid/base catalyst for full activation of dual-specificity phosphatase MKP3 by extracellular regulated kinase.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Dual Specificity Phosphatase 3; Dual Specificity Phosphatase 6; Enzyme Activation; Hydrogen-Ion Concentration; Kinetics; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Nitrogen; Nitrogen Isotopes; Nitrophenols; Organophosphorus Compounds; Oxygen Isotopes; Phosphorylation; Protein Tyrosine Phosphatases; Substrate Specificity | 2001 |
Investigation of allosteric linkages in the regulation of tryptophan synthase: the roles of salt bridges and monovalent cations probed by site-directed mutation, optical spectroscopy, and kinetics.
Topics: Alanine; Allosteric Regulation; Asparagine; Aspartic Acid; Cations, Monovalent; Deuterium; Dimerization; Enzyme Activation; Kinetics; Lysine; Multienzyme Complexes; Mutagenesis, Site-Directed; Potassium; Quaternary Ammonium Compounds; Salmonella typhimurium; Salts; Sodium; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Threonine; Titrimetry; Tryptophan Synthase | 2001 |
Ion chromatographic analysis of selected free amino acids and cations to investigate the change of nitrogen metabolism by herbicide stress in soybean (glycine max).
Topics: Alanine; Amino Acids; Arylsulfonates; Asparagine; Aspartic Acid; Cations; Chromatography, Ion Exchange; Glutamine; Glycine max; Herbicides; Nitrogen; Plant Structures; Potassium; Quaternary Ammonium Compounds; Sodium; Tissue Distribution | 2001 |
Mechanism of asparagine deamidation during human senile cataractogenesis.
Topics: Asparagine; Aspartic Acid; Cataract; Chromatography, High Pressure Liquid; Crystallins; Deamination; Humans; Succinimides | 2001 |
Asparagine 23 and aspartate 305 are essential residues in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase from Enterobacter cloacae.
Topics: Alkyl and Aryl Transferases; Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Cysteine; Enterobacter cloacae; Enzyme Inhibitors; Fosfomycin; Mutagenesis, Site-Directed; Phosphates; Phosphoenolpyruvate; Recombinant Proteins; Uridine Diphosphate N-Acetylglucosamine | 2001 |
Structures of the acyl-enzyme complexes of the Staphylococcus aureus beta-lactamase mutant Glu166Asp:Asn170Gln with benzylpenicillin and cephaloridine.
Topics: Acylation; Amino Acid Substitution; Asparagine; Aspartic Acid; beta-Lactamases; Binding Sites; Catalysis; Cephaloridine; Crystallization; Crystallography, X-Ray; Escherichia coli; Glutamic Acid; Glutamine; Hydrolysis; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; Penicillin G; Staphylococcus aureus; Substrate Specificity | 2001 |
The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition.
Topics: Aminobutyrates; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Computer Simulation; Crystallography, X-Ray; Electrons; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamic Acid; Models, Molecular; Salmonella typhimurium; Spectroscopy, Fourier Transform Infrared; Static Electricity; Substrate Specificity; Thallium; Tyrosine | 2001 |
Proton transfer in Azotobacter vinelandii ferredoxin I: entatic Lys84 operates as elastic counterbalance for the proton-carrying Asp15.
Topics: Asparagine; Aspartic Acid; Azotobacter vinelandii; Energy Metabolism; Ferredoxins; Lysine; Models, Molecular; Mutation; Protein Conformation; Proton Pumps | 2001 |
Stabilization of apoflavodoxin by replacing hydrogen-bonded charged Asp or Glu residues by the neutral isosteric Asn or Gln.
Topics: Amino Acid Substitution; Anabaena; Apoproteins; Asparagine; Aspartic Acid; Bacterial Proteins; Base Sequence; Circular Dichroism; Cyanobacteria; Flavodoxin; Glutamic Acid; Glutamine; Hot Temperature; Hydrogen Bonding; Hydrogen-Ion Concentration; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Protein Denaturation; Urea | 2001 |
Autism: evidence of association with adenosine deaminase genetic polymorphism.
Topics: Adenosine Deaminase; Adolescent; Alleles; Amino Acid Substitution; Asparagine; Aspartic Acid; Autistic Disorder; Child; Child, Preschool; Female; Genotype; Humans; Italy; Male; Polymorphism, Genetic; Reference Values; Risk Factors; White People | 2001 |
Characterization of mutants of beta histidine91, beta aspartate213, and beta asparagine222, possible components of the energy transduction pathway of the proton-translocating pyridine nucleotide transhydrogenase of Escherichia coli.
Topics: Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Energy Metabolism; Escherichia coli; Histidine; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; NADP; NADP Transhydrogenases; Oxidation-Reduction; Protein Conformation | 2001 |
Active site residues of glutamate racemase.
Topics: Amino Acid Isomerases; Amino Acid Sequence; Asparagine; Aspartic Acid; Bacterial Proteins; Binding Sites; Deuterium; Glutamic Acid; Glutamine; Histidine; Isoenzymes; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; Sequence Alignment | 2001 |
Folate activation and catalysis in methylenetetrahydrofolate reductase from Escherichia coli: roles for aspartate 120 and glutamate 28.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Catalysis; Enzyme Activation; Escherichia coli; Folic Acid; Glutamic Acid; Glutamine; Kinetics; Methylenetetrahydrofolate Dehydrogenase (NAD+); Methylenetetrahydrofolate Reductase (NADPH2); Mutagenesis, Site-Directed; NAD; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Oxidoreductases; Oxidoreductases Acting on CH-NH Group Donors; Spectrophotometry; Vitamin K | 2001 |
Mechanistic implications of methylglyoxal synthase complexed with phosphoglycolohydroxamic acid as observed by X-ray crystallography and NMR spectroscopy.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Binding, Competitive; Carbon-Oxygen Lyases; Chemical Fractionation; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli; Glycolates; Hydroxamic Acids; Kinetics; Macromolecular Substances; Nuclear Magnetic Resonance, Biomolecular; Protons; Recombinant Proteins; Triose-Phosphate Isomerase | 2001 |
Resonance Raman and EPR investigations of the D251N oxycytochrome P450cam/putidaredoxin complex.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Camphor 5-Monooxygenase; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Electron Transport; Ferredoxins; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxygen; Oxygen Isotopes; Pseudomonas putida; Spectrum Analysis, Raman | 2001 |
In vivo modifications of the maize mitochondrial small heat stress protein, HSP22.
Topics: Alternative Splicing; Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Chromatography; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; DNA, Complementary; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Heat-Shock Proteins; Introns; Mass Spectrometry; Mitochondria; Molecular Sequence Data; Phosphorylation; Serine; Zea mays | 2001 |
Catalytic acid-base groups in yeast pyruvate decarboxylase. 3. A steady-state kinetic model consistent with the behavior of both wild-type and variant enzymes at all relevant pH values.
Topics: Acetaldehyde; Alanine; Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Catalytic Domain; Computer Simulation; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Pyruvate Decarboxylase; Pyruvates; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity | 2001 |
A Ty1 reverse transcriptase active-site aspartate mutation blocks transposition but not polymerization.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Glutamic Acid; Mutation; Retroelements; RNA-Directed DNA Polymerase; Transcription, Genetic; Yeasts | 2001 |
Synergistic interactions of multiple mutations on catalysis during the hydroxylation reaction of p-hydroxybenzoate hydroxylase: studies of the Lys297Met, Asn300Asp, and Tyr385Phe mutants reconstituted with 8-Cl-flavin.
Topics: 4-Hydroxybenzoate-3-Monooxygenase; Alanine; Amino Acid Substitution; Anaerobiosis; Asparagine; Aspartic Acid; Catalysis; Flavin-Adenine Dinucleotide; Hydroxylation; Lysine; Methionine; Mutagenesis, Site-Directed; Oxidation-Reduction; Parabens; Phenylalanine; Riboflavin; Serine; Spectrophotometry; Substrate Specificity; Tyrosine | 2001 |
Tryptophan residues at subunit interfaces used as fluorescence probes to investigate homotropic and heterotropic regulation of aspartate transcarbamylase.
Topics: Allosteric Regulation; Asparagine; Aspartate Carbamoyltransferase; Aspartic Acid; Escherichia coli; Fluorescent Dyes; Kinetics; Peptide Fragments; Phenylalanine; Phosphonoacetic Acid; Spectrometry, Fluorescence; Substrate Specificity; Titrimetry; Tryptophan; Tyrosine | 2001 |
Neighboring side chain effects on asparaginyl and aspartyl degradation: an ab initio study of the relationship between peptide conformation and backbone NH acidity.
Topics: Amides; Asparagine; Aspartic Acid; Glycine; Models, Chemical; Nitrogen; Protein Conformation; Proteins; Succinimides | 2001 |
Alternate substrate binding modes to two mutant (D98N and H255N) forms of nitrite reductase from Alcaligenes faecalis S-6: structural model of a transient catalytic intermediate.
Topics: Alcaligenes; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Copper; Crystallization; Crystallography, X-Ray; Histidine; Hydrogen Bonding; Models, Molecular; Mutagenesis, Site-Directed; Nitrite Reductases; Nitrites; Oxidation-Reduction; Substrate Specificity | 2001 |
Caspase-mediated cleavage of the Ca2+/calmodulin-dependent protein kinase-like kinase facilitates neuronal apoptosis.
Topics: Animals; Apoptosis; Asparagine; Aspartic Acid; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Line; Cells, Cultured; Culture Media, Serum-Free; DNA; DNA, Complementary; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Immunohistochemistry; Neurons; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Rabbits; Reticulocytes; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine; Subcellular Fractions; Tumor Cells, Cultured | 2001 |
A program of Yersinia enterocolitica type III secretion reactions is activated by specific signals.
Topics: Albumins; Asparagine; Aspartic Acid; Bacterial Outer Membrane Proteins; Calcium; Genes, Regulator; Glutamic Acid; Glutamine; HeLa Cells; Humans; Mutation; Signal Transduction; Yersinia enterocolitica | 2001 |
Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloidosis; Asparagine; Aspartic Acid; Chromatography, Gel; Circular Dichroism; Histidine; Humans; Hydrogen-Ion Concentration; Kinetics; Microscopy, Electron; Molecular Sequence Data; Mutation; Peptide Fragments; Protein Folding; Protein Structure, Quaternary; Protein Structure, Secondary | 2001 |
Deamidation of asparagine in a major histocompatibility complex-bound peptide affects T cell recognition but does not explain type B reactivity.
Topics: Animals; Antigen Presentation; Asparagine; Aspartic Acid; Epitopes, T-Lymphocyte; Isoaspartic Acid; Major Histocompatibility Complex; Mice; Muramidase; Peptide Fragments; Peptides; T-Lymphocytes; Tumor Cells, Cultured | 2001 |
Simultaneous replacement of Asp-L210 and Asp-M17 with Asn increases proton uptake by Glu-L212 upon first electron transfer to QB in reaction centers from Rhodobacter sphaeroides.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Deuterium Oxide; Electron Transport; Glutamic Acid; Glutamine; Mutagenesis, Site-Directed; Photosynthetic Reaction Center Complex Proteins; Protons; Quinones; Rhodobacter sphaeroides; Spectroscopy, Fourier Transform Infrared | 2001 |
Beta-amyloid fibrils activate the C1 complex of complement under physiological conditions: evidence for a binding site for A beta on the C1q globular regions.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Asparagine; Aspartic Acid; Binding Sites; Complement C1; Complement C1q; Complement Pathway, Classical; Glutamic Acid; Glutamine; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Peptide Fragments; Protein Structure, Tertiary; Rats | 2001 |
Environment of tryptophan 57 in porcine fructose-1,6-bisphosphatase studied by time-resolved fluorescence and site-directed mutagenesis.
Topics: Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Circular Dichroism; Crystallography, X-Ray; Fructose-Bisphosphatase; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Protein Subunits; Recombinant Proteins; Spectrometry, Fluorescence; Swine; Tryptophan | 2001 |
Mutating aspartate in the calcium-binding site of alpha-lactalbumin: effects on the protein stability and cation binding.
Topics: Animals; Asparagine; Aspartic Acid; Binding Sites; Cattle; Circular Dichroism; Cloning, Molecular; Lactalbumin; Mutation; Spectrometry, Fluorescence; Temperature | 2001 |
Residues 137 and 153 at the N terminus of the XylS protein influence the effector profile of this transcriptional regulator and the sigma factor used by RNA polymerase to stimulate transcription from its cognate promoter.
Topics: Amino Acids; Asparagine; Aspartic Acid; Bacterial Proteins; beta-Galactosidase; DNA; DNA-Binding Proteins; DNA-Directed RNA Polymerases; Escherichia coli; Glutamic Acid; Histidine; Mutation; Plasmids; Point Mutation; Promoter Regions, Genetic; Protein Structure, Tertiary; RNA; Trans-Activators; Transcription, Genetic | 2002 |
Reciprocal mutations of highly conserved residues in transmembrane helices 2 and 7 of the alpha(2A)-adrenoceptor restore agonist activation of G(i1)alpha.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Asparagine; Aspartic Acid; Conserved Sequence; COS Cells; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Isoquinolines; Mutation; Naphthyridines; Protein Structure, Tertiary; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins | 2002 |
Retention at the cis-Golgi and delayed degradation of tissue-non-specific alkaline phosphatase with an Asn153-->Asp substitution, a cause of perinatal hypophosphatasia.
Topics: Alkaline Phosphatase; Amino Acids; Animals; Asparagine; Aspartic Acid; Biological Transport; Biotinylation; Brefeldin A; Cell Membrane; Centrifugation, Density Gradient; COS Cells; Dimerization; Golgi Apparatus; Humans; Hypophosphatasia; Microscopy, Fluorescence; Mutation; Mutation, Missense; Plasmids; Precipitin Tests; Protein Folding; Protein Synthesis Inhibitors; Time Factors; Transfection; Type C Phospholipases | 2002 |
Two "wild-type" variants of Escherichia coli sigma(70): context-dependent effects of the identity of amino acid 149.
Topics: Amino Acid Substitution; Amino Acids; Asparagine; Aspartic Acid; DNA-Directed RNA Polymerases; Escherichia coli; Genetic Variation; Sequence Deletion; Sigma Factor; Transcription, Genetic | 2002 |
Importance of Na,K-ATPase residue alpha 1-Arg544 in the segment Arg544-Asp567 for high-affinity binding of ATP, ADP, or MgATP.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine; Amino Acid Substitution; Animals; Arginine; Asparagine; Aspartic Acid; Binding Sites; Conserved Sequence; Cysteine; Glutamic Acid; Magnesium; Mutagenesis, Site-Directed; Peptide Fragments; Phosphorylation; Saccharomyces cerevisiae; Serine; Sodium-Potassium-Exchanging ATPase; Swine; Thermodynamics | 2002 |
Transfer RNA-dependent amino acid biosynthesis: an essential route to asparagine formation.
Topics: Amino Acids; Asparagine; Aspartate-tRNA Ligase; Aspartic Acid; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Escherichia coli; Eubacterium; RNA, Transfer, Amino Acyl | 2002 |
Positive contribution of hydration structure on the surface of human lysozyme to the conformational stability.
Topics: Arginine; Asparagine; Aspartic Acid; Crystallography, X-Ray; Humans; Models, Molecular; Muramidase; Mutation; Protein Binding; Protein Conformation; Serine; Thermodynamics; Tyrosine; Valine; Water | 2002 |
Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
Topics: Adenosylhomocysteinase; Animals; Apoenzymes; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Cattle; Circular Dichroism; Crystallography, X-Ray; DNA, Complementary; Escherichia coli; Holoenzymes; Hydrolases; Hydrolysis; Kinetics; Liver; Lysine; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; NAD; NADP; Protein Binding; Rats; Time Factors; Ultraviolet Rays | 2002 |
Modulation of the electrostatic charge at the active site of foot-and-mouth-disease-virus leader proteinase, an unusual papain-like enzyme.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Escherichia coli; Eukaryotic Initiation Factor-4G; Foot-and-Mouth Disease Virus; Hydrogen Bonding; Hydrogen-Ion Concentration; Models, Molecular; Mutagenesis, Site-Directed; Papain; Peptide Initiation Factors; Serine; Static Electricity | 2002 |
Structure of Ala24/Asp61 --> Asp24/Asn61 substituted subunit c of Escherichia coli ATP synthase: implications for the mechanism of proton transport and rotary movement in the F0 complex.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Bacterial Proton-Translocating ATPases; Computer Simulation; Crystallography, X-Ray; Escherichia coli Proteins; Mitochondrial Proton-Translocating ATPases; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Thermodynamics | 2002 |
Isoaspartyl dipeptidase activity of plant-type asparaginases.
Topics: Amidohydrolases; Amino Acid Sequence; Anabaena; Arabidopsis; Arginine; Asparaginase; Asparagine; Aspartic Acid; Aspartylglucosylaminase; Bacterial Proteins; Cloning, Molecular; Cyanobacteria; Dipeptidases; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Genetic Vectors; Immunoblotting; Mass Spectrometry; Molecular Sequence Data; Peptides; Plant Proteins; Protein Biosynthesis; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2002 |
An essential amino acid residue for catalytic activity of the dextranase of Streptococcus mutans.
Topics: Amino Acid Sequence; Amino Acids, Essential; Asparagine; Aspartic Acid; Binding Sites; Dextranase; Glucosyltransferases; Glutamic Acid; Humans; Molecular Biology; Mutagenesis, Site-Directed; Sequence Analysis, Protein; Streptococcus; Streptococcus mutans; Streptococcus sobrinus; Threonine; Valine | 2002 |
Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Computer Simulation; Drug Design; In Vitro Techniques; Male; Membrane Proteins; Protein Structure, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Rhodopsin; Rod Opsins; Serotonin Agents | 2002 |
Effect of replacing the aspartic acid/glutamic acid residues of bullfrog sialic acid binding lectin with asparagine/glutamine and arginine on the inhibition of cell proliferation in murine leukemia P388 cells.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; Arginine; Asparagine; Aspartic Acid; Cell Division; Circular Dichroism; Cloning, Molecular; Escherichia coli; Glutamic Acid; HL-60 Cells; Humans; Lectins; Leukemia P388; Mice; Microscopy, Fluorescence; Mutagenesis, Site-Directed; N-Acetylneuraminic Acid; Rana catesbeiana; Ribonucleases | 2002 |
Pentalenene synthase. Analysis of active site residues by site-directed mutagenesis.
Topics: Asparagine; Aspartic Acid; Binding Sites; Intramolecular Lyases; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Streptomyces | 2002 |
Phase I trial of adoptive immunotherapy with cytolytic T lymphocytes immunized against a tyrosinase epitope.
Topics: Asparagine; Aspartic Acid; Clinical Trials, Phase I as Topic; Codon; Deamination; Epitopes, T-Lymphocyte; Humans; Immunotherapy, Adoptive; Melanoma; Monophenol Monooxygenase; Neoplasm Proteins; Protein Processing, Post-Translational; Sequence Analysis, DNA; T-Lymphocytes; Transplantation, Autologous | 2002 |
Asp1080 upstream of the calmodulin-binding domain is critical for autoinhibition of hPMCA4b.
Topics: Adenosine Triphosphatases; Alanine; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Binding Sites; Calcium; Calcium-Transporting ATPases; Calmodulin; Catalysis; Cation Transport Proteins; Cell Membrane; COS Cells; Dose-Response Relationship, Drug; Kinetics; Lysine; Microsomes; Molecular Sequence Data; Mutation; Plasma Membrane Calcium-Transporting ATPases; Protein Binding; Protein Structure, Tertiary; Time Factors; Transfection | 2002 |
Compound heterozygosity for Hb Korle-Bu (beta(73); Asp-Asn) and Hb E (beta(26); Glu-Lys) with a 3.7-kb deletional alpha-thalassemia in Thai patients.
Topics: Adolescent; Adult; Aged; alpha-Thalassemia; Asparagine; Aspartic Acid; Base Sequence; Chromosome Segregation; Female; Gene Deletion; Glutamic Acid; Hemoglobin E; Hemoglobins, Abnormal; Heterozygote; Humans; Lysine; Male; Middle Aged; Pregnancy; Thailand | 2002 |
Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol.
Topics: 2-Methoxyestradiol; Alanine; Asparagine; Aspartic Acid; Binding Sites; Dihydrotestosterone; Estradiol; Humans; Hydrogen Bonding; Models, Molecular; Molecular Structure; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sex Hormone-Binding Globulin; Zinc | 2002 |
Characterization of asparagine deamidation and aspartate isomerization in recombinant human interleukin-11.
Topics: Amides; Amino Acid Sequence; Asparagine; Aspartic Acid; Humans; Interleukin-11; Isomerism; Molecular Sequence Data; Recombinant Proteins; Sequence Analysis, Protein | 2002 |
Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine beta-synthase.
Topics: Allosteric Regulation; Amino Acid Substitution; Asparagine; Aspartic Acid; Carbon Monoxide; Cell Line; Cystathionine beta-Synthase; Enzyme Activation; Ferrous Compounds; Fibroblasts; Heme; Humans; Kinetics; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Recombinant Proteins; RNA, Messenger; S-Adenosylmethionine | 2002 |
Antiapoptotic Cdc42 mutants are potent activators of cellular transformation.
Topics: 3T3 Cells; Amino Acid Substitution; Animals; Apoptosis; Asparagine; Aspartic Acid; cdc42 GTP-Binding Protein; Cell Division; Cell Transformation, Neoplastic; COS Cells; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Mice; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Protein Binding; Trans-Activators; Transfection | 2002 |
Amino acid content of cell cultures infected with Cowdria ruminantium propagated in a protein-free medium.
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; Bacteriological Techniques; Cell Line; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media, Serum-Free; Ehrlichia ruminantium; Glutamine; Glycine; Heartwater Disease; Proline; Ruminants; Serine; Tryptophan | 2002 |
Fine-tuning of the binding and dissociation of CO by the amino acids of the heme pocket of Coprinus cinereus peroxidase.
Topics: Amino Acid Substitution; Amino Acids; Anions; Arginine; Asparagine; Aspartic Acid; Carbon Monoxide; Coprinus; Cytochrome-c Peroxidase; Ferrous Compounds; Heme; Kinetics; Ligands; Mutation; Peroxidase; Phenylalanine; Protein Binding; Spectrophotometry, Infrared; Spectrum Analysis, Raman | 2002 |
A mutation in subunit I of cytochrome oxidase from Rhodobacter sphaeroides results in an increase in steady-state activity but completely eliminates proton pumping.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Cold Temperature; Electron Transport Complex IV; Enzyme Activation; Heme; Kinetics; Mutagenesis, Site-Directed; Oxidation-Reduction; Photolysis; Proton Pumps; Rhodobacter sphaeroides; Spectrophotometry, Ultraviolet | 2002 |
Cancer. DNA damage, deamidation, and death.
Topics: Antineoplastic Agents; Apoptosis; Asparagine; Aspartic Acid; bcl-X Protein; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Damage; DNA, Neoplasm; Genes, p53; Genes, Retinoblastoma; Humans; Models, Biological; Mutation; Neoplasms; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Retinoblastoma Protein; Tumor Suppressor Protein p53 | 2002 |
Excitatory amino acid release in the spinal cord caused by plantar incision in the rat.
Topics: Animals; Asparagine; Aspartic Acid; Dermatologic Surgical Procedures; Glutamic Acid; Glutamine; Glycine; Male; Microdialysis; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Serine; Spinal Cord | 2002 |
Mutation of Asn293 to Asp in transmembrane helix VI abolishes agonist-induced but not constitutive activity of the beta(2)-adrenergic receptor.
Topics: Adrenergic Agonists; Adrenergic beta-2 Receptor Agonists; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; CHO Cells; Cricetinae; Membrane Proteins; Mutation; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Adrenergic, beta-2 | 2002 |
Chemical cleavage of polypeptides.
Topics: Asparagine; Aspartic Acid; Cysteine; Glycine; Methionine; Peptides; Sequence Analysis, Protein; Tryptophan | 2003 |
Differential ligand recognition by the Src and phosphatidylinositol 3-kinase Src homology 3 domains: circular dichroism and ultraviolet resonance Raman studies.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Circular Dichroism; Kinetics; Ligands; Peptide Fragments; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins pp60(c-src); Spectrum Analysis, Raman; src Homology Domains; Tryptophan; Tyrosine | 2003 |
Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.
Topics: Amino Acid Substitution; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Asparagine; Aspartic Acid; Aspartic Acid Endopeptidases; Carbamates; Cell Line; Cell-Free System; CHO Cells; Cricetinae; Culture Media; Dipeptides; Endopeptidases; Humans; Intracellular Fluid; Isoleucine; Membrane Proteins; Methionine; Mutagenesis, Site-Directed; Peptide Fragments; Presenilin-1; Presenilin-2; Serine Proteinase Inhibitors; Threonine; Transfection; Up-Regulation; Valine | 2003 |
Deamidations in recombinant human phenylalanine hydroxylase. Identification of labile asparagine residues and functional characterization of Asn --> Asp mutant forms.
Topics: Amides; Amino Acid Sequence; Asparagine; Aspartic Acid; Catalytic Domain; Enzyme Stability; Humans; Kinetics; Mutagenesis, Site-Directed; Mutation, Missense; Phenylalanine Hydroxylase; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2003 |
Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis.
Topics: Amino Acid Sequence; Animals; Arginine; Asparagine; Aspartic Acid; Binding Sites; Catalytic Domain; COS Cells; Crystallography, X-Ray; Heparitin Sulfate; Hydrogen Bonding; Membrane Proteins; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Acetylgalactosaminyltransferases; N-Acetylglucosaminyltransferases; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Transfection; Uridine Diphosphate N-Acetylglucosamine | 2003 |
Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Circular Dichroism; Crystallography, X-Ray; DNA; DNA-Formamidopyrimidine Glycosylase; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Glutamic Acid; Glutamine; Hot Temperature; Humans; Hydrolysis; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Glycosyl Hydrolases; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Substrate Specificity | 2003 |
Comprehensive model for allosteric regulation of mammalian ribonucleotide reductase: refinements and consequences.
Topics: Adenosine Triphosphate; Allosteric Regulation; Animals; Asparagine; Aspartic Acid; Cytidine Diphosphate; Deoxyadenine Nucleotides; Dimerization; Enzyme Activation; Guanosine Diphosphate; Kinetics; Light; Magnesium; Mice; Models, Chemical; Mutagenesis, Site-Directed; Protein Subunits; Recombinant Proteins; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases; Scattering, Radiation; Substrate Specificity; Thymine Nucleotides; Tumor Cells, Cultured | 2003 |
[Association of genetic polymorphisms in the DNA repair gene XPD with risk of lung and esophageal cancer in a Chinese population in Beijing].
Topics: Adenocarcinoma; Asparagine; Aspartic Acid; Carcinoma, Squamous Cell; China; DNA; DNA Helicases; DNA Repair; DNA-Binding Proteins; Esophageal Neoplasms; Female; Gene Frequency; Genotype; Humans; Logistic Models; Lung Neoplasms; Male; Multivariate Analysis; Odds Ratio; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proteins; Risk Factors; Smoking; Transcription Factors; Xeroderma Pigmentosum Group D Protein | 2003 |
An opsin mutant with increased thermal stability.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Cattle; COS Cells; Cross-Linking Reagents; Cysteine; Disulfides; Dithiothreitol; Light; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Denaturation; Recombinant Proteins; Retinaldehyde; Rhodopsin; Thermodynamics; Transducin; Transfection | 2003 |
Engineering a catalytic metal binding site into a calcium-independent phosphatidylinositol-specific phospholipase C leads to enhanced stereoselectivity.
Topics: Animals; Arginine; Asparagine; Aspartic Acid; Bacillus; Bacterial Proteins; Binding Sites; Calcium; Catalytic Domain; Cattle; Glutamic Acid; Glutamine; Metals, Alkaline Earth; Mutagenesis, Site-Directed; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Stereoisomerism; Streptomyces antibioticus; Substrate Specificity; Type C Phospholipases | 2003 |
Effect of aspartate and asparagine supplementation on fatigue determinants in intense exercise.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Blood Glucose; Dietary Supplements; Glutamine; Glycogen; Lactic Acid; Liver Glycogen; Male; Muscle Fatigue; Muscle, Skeletal; Physical Conditioning, Animal; Physical Exertion; Random Allocation; Rats; Rats, Wistar; Swimming | 2003 |
Redox potential of quinones in photosynthetic reaction centers from Rhodobacter sphaeroides: dependence on protonation of Glu-L212 and Asp-L213.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Deuterium Oxide; Electron Transport; Glutamic Acid; Glutamine; Light; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Photosynthetic Reaction Center Complex Proteins; Protein Conformation; Protons; Quinones; Rhodobacter sphaeroides; Spectroscopy, Fourier Transform Infrared | 2003 |
Increased lysine synthesis coupled with a knockout of its catabolism synergistically boosts lysine content and also transregulates the metabolism of other amino acids in Arabidopsis seeds.
Topics: Amino Acids; Arabidopsis; Asparagine; Aspartic Acid; Bacteria; Bacterial Proteins; Gene Expression Regulation, Plant; Germination; Glutamic Acid; Glutamine; Hydro-Lyases; Lysine; Methionine; Mutation; Plants, Genetically Modified; Pterocarpans; Seeds; Signal Transduction; Threonine | 2003 |
Biochemical and structural analysis of the molybdenum cofactor biosynthesis protein MobA.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Catalysis; Catalytic Domain; Crystallography, X-Ray; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Genetic Complementation Test; Glycine; Models, Molecular; Molecular Sequence Data; Molybdenum; Mutagenesis, Site-Directed; Mutation; Nitrate Reductase; Nitrate Reductases; Plasmids; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship; Sulfurtransferases; Trans-Activators; Two-Hybrid System Techniques | 2003 |
Characterization of the Prr1 response regulator with special reference to sexual development in Schizosaccharomyces pombe.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Blotting, Northern; Cell Adhesion Molecules; Genes, Fungal; Meiosis; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Nectins; Nitrogen; Oxidative Stress; Phenotype; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Signal Transduction; Transcription Factors | 2003 |
Identification of the L-aspartate transporter in Bacillus subtilis.
Topics: Amino Acid Transport Systems, Acidic; Amino Acids; Asparagine; Aspartic Acid; Bacillus subtilis; Bacterial Proteins; Carrier Proteins; Cell Division; Cloning, Molecular; Glutamic Acid; Mutation; Phylogeny; Recombinant Fusion Proteins; Substrate Specificity | 2003 |
Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; Asparagine; Aspartic Acid; Camptothecin; COS Cells; Exons; Genetic Variation; Glucuronates; Glucuronic Acid; Glucuronosyltransferase; Humans; Irinotecan; Japan; Mutation; Neoplasms; Polymorphism, Single Nucleotide; Transfection; UDP-Glucuronosyltransferase 1A9 | 2003 |
Central role of a serine phosphorylation site within duck hepatitis B virus core protein for capsid trafficking and genome release.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Binding Sites; Blotting, Western; Capsid; Cell Nucleus; Centrifugation, Density Gradient; Chickens; DNA, Circular; DNA, Viral; Hepatitis B Virus, Duck; Hydrogen Bonding; Microscopy, Confocal; Mutation; Phosphorylation; Precipitin Tests; Serine; Transfection | 2003 |
Two-electrode voltage-clamp analysis of Na,K-ATPase asparagine 776 mutants.
Topics: Alanine; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Female; Glutamine; Kinetics; Oocytes; Patch-Clamp Techniques; Protein Subunits; Rats; Recombinant Proteins; Sodium-Potassium-Exchanging ATPase; Xenopus | 2003 |
Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study.
Topics: Analysis of Variance; Animals; Asparagine; Aspartic Acid; Brain Ischemia; Cerebral Hemorrhage; Chromatography, High Pressure Liquid; Disease Models, Animal; Extracellular Space; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Microdialysis; Prospective Studies; Rabbits; Single-Blind Method; Stroke; Taurine; Time Factors | 2003 |
Two homozygous mutations in the 11 beta-hydroxysteroid dehydrogenase type 2 gene in a case of apparent mineralocorticoid excess.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Asparagine; Aspartic Acid; Base Sequence; Child, Preschool; CHO Cells; Cricetinae; Cysteine; Homozygote; Humans; Hydroxysteroid Dehydrogenases; Male; Mineralocorticoids; Models, Molecular; Mutation; Polymorphism, Single Nucleotide; Threonine | 2003 |
Thapsigargin selectively rescues the trafficking defective LQT2 channels G601S and F805C.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Cation Transport Proteins; Cell Line; Cell Membrane; Cell Nucleus; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Glycine; Humans; Long QT Syndrome; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Transport; Recombinant Proteins; Serine; Thapsigargin; Trans-Activators; Transcriptional Regulator ERG | 2003 |
Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Cell Line; Cells, Cultured; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine Endopeptidases; Dendritic Cells; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Lipopolysaccharides; Lysosomes; Microscopy, Fluorescence; Models, Biological; Molecular Sequence Data; Monocytes; Mutagenesis, Site-Directed; Mutation; Peptides; Plant Proteins; Protein Structure, Tertiary; Rabbits; Sheep; Time Factors; Transfection | 2003 |
Sequence context strongly modulates association of polar residues in transmembrane helices.
Topics: Amino Acid Sequence; Amino Acids, Acidic; Amino Acids, Basic; Asparagine; Aspartic Acid; Capsid; Capsid Proteins; Glutamic Acid; Glutamine; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Membrane Proteins; Protein Structure, Tertiary; Recombinant Fusion Proteins | 2003 |
Lipoprotein lipase activity and common gene variants in severely hypertriglyceridemic patients with and without diabetes.
Topics: Adult; Apolipoproteins; Asparagine; Aspartic Acid; Diabetes Complications; Diabetes Mellitus; Female; Genetic Variation; Glutamic Acid; Glycine; Humans; Hyperlipoproteinemia Type IV; Lipoprotein Lipase; Male; Middle Aged; Phenotype; Serine; Severity of Illness Index | 2003 |
Crystal structure of a mini-intein reveals a conserved catalytic module involved in side chain cyclization of asparagine during protein splicing.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Bacterial Proteins; Binding Sites; Carbon; Catalysis; Catalytic Domain; Crystallography, X-Ray; Cyanobacteria; DNA Helicases; DnaB Helicases; Genetic Vectors; Histidine; Models, Chemical; Models, Genetic; Models, Molecular; Molecular Sequence Data; Oxygen; Peptides; Protein Conformation; Protein Splicing; Protein Structure, Tertiary; RNA Splicing; Sequence Homology, Amino Acid; Structure-Activity Relationship; Water | 2003 |
Effect of additional N-glycosylation signal in the N-terminal region on intracellular function of the human gonadotropin alpha-subunit.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; CHO Cells; Chorionic Gonadotropin, beta Subunit, Human; Cricetinae; Cricetulus; Dimerization; Electrophoretic Mobility Shift Assay; Glutamine; Glycoprotein Hormones, alpha Subunit; Glycosylation; Humans; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mutation; Terminal Repeat Sequences; Threonine | 2003 |
Specific isotopic labeling and photooxidation-linked structural changes in the manganese-stabilizing subunit of photosystem II.
Topics: Asparagine; Aspartic Acid; Escherichia coli; Gas Chromatography-Mass Spectrometry; Gene Expression; Glutamic Acid; Glutamine; Isotope Labeling; Manganese; Oxidation-Reduction; Photochemistry; Photosynthesis; Photosystem II Protein Complex; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared; Water | 2003 |
A method for the detection of asparagine deamidation and aspartate isomerization of proteins by MALDI/TOF-mass spectrometry using endoproteinase Asp-N.
Topics: Amides; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Chickens; Deamination; Egg White; Endopeptidases; Isomerism; Metalloendopeptidases; Molecular Sequence Data; Muramidase; Nitrogen Isotopes; Peptide Fragments; Recombinant Proteins; Sequence Analysis, Protein; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2003 |
Evolution of amino acid metabolism inferred through cladistic analysis.
Topics: Amino Acids; Asparagine; Aspartic Acid; Biochemical Phenomena; Biochemistry; Biological Evolution; Citric Acid Cycle; Enzymes; Glutamic Acid; Glutamine; Models, Biological; Multigene Family; Phylogeny; Software; Statistics as Topic; Substrate Specificity | 2003 |
Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Motifs; Amino Acid Sequence; Amino Acids; Animals; Anions; Asparagine; Aspartic Acid; Binding Sites; Biological Transport; Cell Line; Cytoplasm; Drug Resistance; Estradiol; Humans; Hydrolysis; Kinetics; Leukotriene C4; Lysine; Mice; Models, Molecular; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Mutation; Nucleic Acid Synthesis Inhibitors; Protein Binding; Protein Structure, Tertiary; Rats; Serine; Time Factors; Transfection | 2003 |
Phenotypic changes resulting from distinct point mutations in the Azospirillum brasilense glnA gene, encoding glutamine synthetase.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Azospirillum brasilense; Binding Sites; Genes, Bacterial; Glutamate-Ammonia Ligase; Point Mutation; Quaternary Ammonium Compounds; Recombinant Fusion Proteins | 2003 |
Experimental evidence for lack of homodimerization of the G protein-coupled human N-formyl peptide receptor.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Calcium; Cell Membrane; Chemotaxis, Leukocyte; CHO Cells; Cricetinae; Dimerization; Endocytosis; Enzyme Activation; Epitopes; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Oligopeptides; Peptides; Precipitin Tests; Receptors, Formyl Peptide; Transfection | 2003 |
Rearrangement of charge-charge interactions in variant ubiquitins as detected by double-mutant cycles and NMR.
Topics: Animals; Asparagine; Aspartic Acid; Cattle; Hydrogen-Ion Concentration; Lysine; Models, Molecular; Mutation; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Tertiary; Ubiquitin | 2003 |
The biosynthesis of dicarboxylic amino acids and enzymic transformations of amides in plants.
Topics: Amides; Amino Acids, Dicarboxylic; Anesthetics, Local; Asparagine; Aspartic Acid; Biochemical Phenomena; Glutamates; Glutamine; Plants | 1958 |
Enthalpies of hydrolysis of glutamine and asparagine and of ionization of glutamic and aspartic acids.
Topics: Asparagine; Aspartic Acid; Glutamates; Glutamine; Hydrolysis; Thermodynamics | 1959 |
Heat capacities from 11 to 305 degree K, entropies and free energies of formation of L-asparagine monohydrate, L-aspartic acid, L-glutamic acid, and L-glutamine.
Topics: Asparagine; Aspartic Acid; Entropy; Glutamates; Glutamic Acid; Glutamine; Hot Temperature | 1963 |
Angiotensinase with a high degree of specificity in plasma and red cells.
Topics: Angiotensin II; Asparagine; Aspartic Acid; Endopeptidases; Erythrocytes; Humans; Kidney; Peptide Hydrolases; Plasma | 1963 |
[RESEARCH ON THE NUTRITION OF ERWINIA CAROTOVORA].
Topics: Alanine; Aminobutyrates; Ammonium Compounds; Arginine; Asparagine; Aspartic Acid; Boron; Calcium; Cobalt; Copper; Creatine; Creatinine; Culture; Culture Media; Cysteine; Cystine; Erwinia; Glutamates; Glycine; Iron; Lysine; Magnesium; Manganese; Methionine; Minerals; Molybdenum; Pectobacterium carotovorum; Proteins; Quaternary Ammonium Compounds; Tryptophan; Tyrosine; Zinc | 1963 |
[MECHANISMS OF AMINO ACID SYNTHESIS IN LEAVES. STUDIES USING RADIOCARBON].
Topics: Alanine; Amino Acids; Aminobutyrates; Ammonium Compounds; Asparagine; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Chromatography; Darkness; Glutamates; Glutamine; Glycine; Light; Methionine; Nitrates; Plant Proteins; Proteins; Quaternary Ammonium Compounds; Research; Serine; Threonine | 1963 |
[FURTHER CLINICAL AND BIOCHEMICAL VERIFICATIONS OF THE THERAPEUTIC ACTION OF ASPARTIC ACID IN CHRONIC HEPATITIS].
Topics: Alanine Transaminase; Amino Acids; Asparagine; Aspartic Acid; Blood Proteins; Diuresis; Hepatitis; Hepatitis A; Hepatitis, Chronic; Humans; Methionine; Urine | 1963 |
PAPER CHROMATOGRAPHY USING LIQUID ION EXCHANGERS.
Topics: Amino Acids; Asparagine; Aspartic Acid; Chromatography; Chromatography, Paper; Glutamates; Glutamine; Ion Exchange Resins; Research | 1963 |
CARBON DIOXIDE FIXATION IN THE JA-1 SARCOMA IN VITRO.
Topics: Alanine; Asparagine; Aspartic Acid; Carbon Dioxide; Carbon Isotopes; Coenzyme A; Fumarates; Glutamates; Glutamine; In Vitro Techniques; Isoleucine; Leucine; Metabolism; Propionates; Proteins; Pyruvates; Sarcoma; Sarcoma, Experimental; Succinates | 1963 |
ASPARAGINE-C14 AND GLUTAMINE-C14 FROM ANIMAL CELL PROTEIN AND THEIR CHEMICAL DEGRADATION.
Topics: Animals; Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography; Glutamine; Ion Exchange Resins; Malates; Neoplasm Proteins; Neoplasms; Neoplasms, Experimental; Proteins; Research; Sarcoma; Sarcoma, Experimental | 1963 |
THE BIOSYNTHESIS OF ASPARAGINE IN THE ETIOLATED SOYBEAN SEEDLING. II. CONVERSION IN VITRO OF GLUTAMIC ACID AND ASPARTIC ACID TO ASPARAGINE.
Topics: Asparagine; Aspartate Aminotransferases; Aspartic Acid; Darkness; Glutamates; Glutamic Acid; Glycine max; In Vitro Techniques; Plant Proteins; Proteins; Research; Seedlings | 1963 |
THE METABOLISM OF THE ORGANIC ACIDS OF TOBACCO LEAVES. XX. EFFECT OF CULTURE OF EXCISED LEAVES IN SOLUTIONS OF POTASSIUM ASPARTATE AND OF ASPARAGINE.
Topics: Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography; Citrates; Culture Media; Glutamine; Ion Exchange Resins; Malates; Metabolism; Nicotiana; Pharmacology; Proteins; Research; Succinates | 1963 |
[RESEARCH ON THE ROLE OF THE CECAL WALL OF THE RABBIT IN THE METABOLISM OF AMINO ACIDS].
Topics: Alanine; Amino Acids; Animals; Asparagine; Aspartic Acid; Blood Chemical Analysis; Cecum; Chromatography; Glutamates; Glutamine; Perfusion; Physiology; Proteins; Rabbits; Research | 1963 |
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Glutamine; Glycine; Humans; Isoleucine; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms; Neoplasms, Experimental; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine | 1964 |
THE ROLE OF DISPENSABLE AMINO ACIDS IN THE NUTRITION OF THE RAT.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Bicarbonates; Caseins; Cystine; Dietary Proteins; Glutamates; Glycine; Growth; Histidine; Isoleucine; Lysine; Methionine; Phenylalanine; Proline; Proteins; Rats; Research; Serine; Tyrosine | 1964 |
[SEPARATION OF AMINO ACIDS BY CHROMATOGRAPHY ON THIN LAYERS OF DIETHYLAMINOETHYL CELLULOSE].
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cellulose; Chromatography; Cystine; Glutamates; Glycine; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Proline; Research; Serine; Threonine; Tryptophan; Tyrosine; Valine | 1964 |
BIOSYNTHESIS OF BACITRACIN. I. FORMATION OF BACITRACIN BY A SUBCELLULAR FRACTION OF BACILLUS LICHENIFORMIS.
Topics: Asparagine; Aspartic Acid; Bacillus; Bacitracin; Carbon Isotopes; Chromatography; Cysteine; Cystine; Glutamates; Glutathione; Histidine; Isoleucine; Lysine; Metabolism; Micrococcus; Ornithine; Phenylalanine; Research; Subcellular Fractions; Sulfhydryl Compounds; Sulfur Isotopes | 1964 |
COLORIMETRIC DIFFERENTIATION OF ALPHA- AND EPSILON-N-SUBSTITUTED LYSINE DERIVATIVES.
Topics: Aminocaproates; Aminocaproic Acid; Asparagine; Aspartic Acid; Chemical Phenomena; Chemistry; Colorimetry; Lysine; Ornithine; Research | 1964 |
[SYNTHESIS OF OPTICALLY ACTIVE N2-PHTHALOYLASPARTIMIDE].
Topics: Asparagine; Aspartic Acid; Chemistry, Pharmaceutical; Imides; Pharmacy; Phthalic Acids; Research | 1964 |
CHEMICALLY DEFINED MEDIUM FOR GROWTH STREPTOCOCCUS PYOGENES.
Topics: Amino Acids; Asparagine; Aspartic Acid; Culture Media; Fermentation; Research; Streptococcus; Streptococcus pyogenes | 1964 |
PURIFICATION AND PROPERTIES OF THE ASPARAGINE SYNTHETASE OF STREPTOCOCCUS BOVIS.
Topics: Amino Acids; Ammonium Chloride; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Chromatography; Dialysis; Diphosphates; Enzyme Inhibitors; Hydroxamic Acids; Ligases; Manganese; Pharmacology; Renal Dialysis; Research; Streptococcus; Streptococcus bovis | 1964 |
AMINO GROUP FORMATION AND GLUTAMATE SYNTHESIS IN STREPTOCOCCUS BOVIS.
Topics: Amino Acids; Asparagine; Aspartic Acid; Carbon; Caseins; Culture Media; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glyceraldehyde-3-Phosphate Dehydrogenases; Isocitrate Dehydrogenase; Metabolism; NAD; NADP; Nitrogen; Nucleotides; Research; Streptococcus; Streptococcus bovis | 1964 |
PROTECTION OF FUNCTIONAL GROUPS IN PEPTIDE SYNTHESIS.
Topics: Adrenocorticotropic Hormone; Amino Acids; Arginine; Asparagine; Aspartic Acid; Chromatography; Melanocyte-Stimulating Hormones; Metabolism; Peptides; Research | 1964 |
CATALYTIC REACTIONS INVOLVING AZOMETHINES. IV. RATES AND EQUILIBRIA OF IMINE FORMATION WITH PYRIDINE-4-ALDEHYDE AND VARIOUS AMINO ACIDS.
Topics: Alanine; Aldehydes; Amino Acids; Arginine; Asparagine; Aspartic Acid; Azo Compounds; Biochemical Phenomena; Biochemistry; Glutamates; Glycine; Imines; Leucine; Phenylalanine; Pyridines; Research; Serine; Spectrophotometry; Thiosemicarbazones; Valine | 1964 |
DETERMINATION OF C-TERMINAL ARGININE AND ASPARAGINE OF PROTEINS BY CATALYTIC HYDRAZINOLYSIS.
Topics: Arginine; Asparagine; Aspartic Acid; Carboxypeptidases; Chemistry Techniques, Analytical; Chromatography; Glutamates; Glutathione; Hydrazines; Insulin; Muramidase; Ornithine; Peptides; Protamines; Proteins; Research | 1964 |
AMINO ACID UTILIZATION BY ALCALIGENES VISCOLACTIS FOR GROWTH AND SLIME PRODUCTION.
Topics: Alcaligenes; Amino Acids; Asparagine; Aspartic Acid; Carbohydrate Metabolism; Colorimetry; Culture Media; Glucose; Glutamic Acid; Glutamine; Lactose; Nitrogen; Proline; Research; Salts; Tyrosine | 1965 |
THE METABOLISM OF THE DIGESTIVE GLANDS OF TWO SPECIES OF MARINE GASTROPOD (MELANERITA MELANOTRAGUS AND AUSTROCOCHLEA OBTUSA).
Topics: Acetates; Alanine; Aminobutyrates; Animals; Asparagine; Aspartic Acid; Autoradiography; Carbohydrate Metabolism; Carbon Dioxide; Chromatography; Citrates; Citric Acid Cycle; Fumarates; Gastrointestinal Tract; Gastropoda; Glucose; Glutamates; Glutamine; Glycolysis; Malates; Mollusca; Research; Succinates | 1965 |
NEMATODE BIOCHEMISTRY. V. INTERMEDIARY METABOLISM AND AMINO ACID INTERCONVERSIONS IN CAENORHABDITIS BRIGGSAE.
Topics: Acetates; Alanine; Amino Acids; Aminobutyrates; Animals; Asparagine; Aspartic Acid; Bicarbonates; Caenorhabditis; Carbon Dioxide; Chromatography; Formates; Glutamates; Glutamine; Glycine; Malates; Nematoda; Phenylalanine; Research; Serine; Taurine; Tyrosine | 1965 |
REGULATION OF CEREBRAL METABOLISM OF AMINO ACIDS. IV. INFLUENCE OF AMINO ACID LEVELS ON LEUCINE UPTAKE, UTILIZATION AND INCORPORATION INTO PROTEIN IN VIVO.
Topics: Amino Acids; Aminobutyrates; Asparagine; Aspartic Acid; Blood Volume; Brain Chemistry; Cerebral Cortex; Diet; Extracellular Space; Glutamates; Glutamine; Inulin; Leucine; Nerve Tissue Proteins; Proteins; Rats; Research; Serum Albumin; Serum Albumin, Radio-Iodinated | 1965 |
Aspartate metabolism and asparagine synthesis in plant systems.
Topics: Asparagine; Aspartic Acid; Plants | 1955 |
Crystal structure of trimestatin, a disintegrin containing a cell adhesion recognition motif RGD.
Topics: Amino Acid Motifs; Amino Acid Sequence; Angiogenesis Inhibitors; Antineoplastic Agents; Asparagine; Aspartic Acid; Blood Platelets; Cell Adhesion; Crystallography, X-Ray; Disintegrins; Integrin alphaVbeta3; Integrins; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Neoplasms; Oligopeptides; Platelet Aggregation; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Snake Venoms; Tryptophan | 2003 |
Dynamics of Ca2+-saturated calmodulin D129N mutant studied by multiple molecular dynamics simulations.
Topics: Asparagine; Aspartic Acid; Binding Sites; Calcium; Calcium-Binding Proteins; Calmodulin; Computer Simulation; EF Hand Motifs; Kinetics; Models, Molecular; Mutation, Missense; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Temperature; Water | 2003 |
Identification of Pseudomonas proteins coordinately induced by acidic amino acids and their amides: a two-dimensional electrophoresis study.
Topics: Asparaginase; Asparagine; Aspartic Acid; Bacterial Proteins; Glutamic Acid; Glutaminase; Glutamine; Periplasm; Proteomics; Pseudomonas fluorescens; Pseudomonas putida; Reverse Transcriptase Polymerase Chain Reaction; Sigma Factor | 2003 |
Fluorescence assay for monitoring Zn-deficient superoxide dismutase in vitro.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Copper; Humans; Kinetics; Motor Neuron Disease; Mutagenesis, Site-Directed; Recombinant Proteins; Spectrometry, Fluorescence; Spectrophotometry; Superoxide Dismutase; Zinc | 2003 |
Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.
Topics: Actins; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Catalysis; cdc42 GTP-Binding Protein; Conserved Sequence; DNA; DNA, Complementary; Enzyme Activation; Escherichia coli; Genes, Dominant; Genes, Reporter; Glutathione Transferase; GTP Phosphohydrolases; Guanine Nucleotide Exchange Factors; Humans; Luciferases; Mice; Microscopy, Fluorescence; Models, Molecular; Molecular Sequence Data; Mutation; NIH 3T3 Cells; Phosphoproteins; Platelet-Derived Growth Factor; Protein Binding; Protein Serine-Threonine Kinases; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Recombinant Fusion Proteins; Recombinant Proteins; Retroviridae; rhoA GTP-Binding Protein; Sequence Homology, Amino Acid; Signal Transduction; Time Factors | 2004 |
Mechanism of phosphatase activity in the chemotaxis response regulator CheY.
Topics: Amides; Amino Acid Sequence; Asparagine; Aspartic Acid; Bacterial Proteins; Chemotaxis; Chromatography, High Pressure Liquid; Enzyme Stability; Hydrolysis; Isoelectric Focusing; Membrane Proteins; Methyl-Accepting Chemotaxis Proteins; Molecular Sequence Data; Oxygen Isotopes; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorus Radioisotopes; Salmonella typhimurium; Succinimides | 2003 |
Redox-coupled proton translocation in biological systems: proton shuttling in cytochrome c oxidase.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Electron Transport Complex IV; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Oxygen Consumption; Protein Conformation; Protons; Rhodobacter sphaeroides | 2003 |
Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin.
Topics: Alanine; Allosteric Site; Asparagine; Aspartic Acid; Binding Sites; Cations; Dose-Response Relationship, Drug; Glutamine; Humans; Hydrolysis; Ions; Kinetics; Lithium; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Conformation; Rubidium; Serine; Sodium; Substrate Specificity; Thrombin; Trypsin | 2004 |
Secondary mutations M36I and A71V in the human immunodeficiency virus type 1 protease can provide an advantage for the emergence of the primary mutation D30N.
Topics: Alanine; Anti-HIV Agents; Asparagine; Aspartic Acid; Binding Sites; Drug Resistance, Viral; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Isoleucine; Kinetics; Methionine; Mutagenesis, Site-Directed; Nelfinavir; Ritonavir; Valine | 2003 |
Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomy
Topics: Adult; Angiography; Arrhythmias, Cardiac; Asparagine; Aspartic Acid; Biomarkers; Cardiomyopathy, Hypertrophic; Death, Sudden, Cardiac; Echocardiography; Exercise Test; Female; Genetic Predisposition to Disease; Heart Ventricles; Humans; Male; Mutation, Missense; Pedigree; Tropomyosin | 2004 |
Consequences of counterion mutation in sensory rhodopsin II of Natronobacterium pharaonis for photoreaction and receptor activation: an FTIR study.
Topics: Archaeal Proteins; Asparagine; Aspartic Acid; Carotenoids; Freezing; Halorhodopsins; Hydrogen-Ion Concentration; Natronobacterium; Photochemistry; Point Mutation; Protons; Receptors, G-Protein-Coupled; Schiff Bases; Sensory Rhodopsins; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared | 2004 |
Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women.
Topics: Adult; Alleles; Asparagine; Aspartic Acid; Body Mass Index; Female; Gene Frequency; Hirsutism; Homozygote; Humans; Microsatellite Repeats; Multivariate Analysis; Obesity; Osmolar Concentration; Polycystic Ovary Syndrome; Polymorphism, Genetic; Sex Hormone-Binding Globulin | 2004 |
Selectivity of retinal photoisomerization in proteorhodopsin is controlled by aspartic acid 227.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Bacteriorhodopsins; Binding Sites; Darkness; Gammaproteobacteria; Hydrogen-Ion Concentration; Isomerism; Light; Retinaldehyde; Rhodopsin; Rhodopsins, Microbial; Solubility; Spectroscopy, Fourier Transform Infrared; Temperature | 2004 |
Utilization of L-,D- and Dl-forms of asparagine and aspartic acid by Leuconostoc mesenteroides P-60.
Topics: Asparagine; Aspartic Acid; Leuconostoc | 1950 |
Mutational analysis of different regions in the coxsackievirus 2B protein: requirements for homo-multimerization, membrane permeabilization, subcellular localization, and virus replication.
Topics: Amino Acid Sequence; Animals; Arginine; Asparagine; Aspartic Acid; Cell Line; Cell Membrane; Chlorocebus aethiops; COS Cells; Dimerization; DNA Mutational Analysis; Enterovirus; Glutamic Acid; Hygromycin B; Kinetics; Lysine; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; Oligonucleotides, Antisense; Permeability; Protein Structure, Tertiary; RNA; Subcellular Fractions; Time Factors; Transfection; Tryptophan; Two-Hybrid System Techniques; Viral Nonstructural Proteins; Virus Replication | 2004 |
T cell recognition of a highly conserved epitope in heat shock protein 60: self-tolerance maintained by TCR distinguishing between asparagine and aspartic acid.
Topics: Antibodies, Monoclonal; Asparagine; Aspartic Acid; Bacterial Proteins; Cells, Cultured; Chaperonin 60; Chaperonins; DNA, Complementary; Epitope Mapping; Epitopes, T-Lymphocyte; Escherichia coli; Escherichia coli Proteins; Heat-Shock Proteins; Humans; Peptides; Receptors, Antigen, T-Cell; Recombinant Proteins; Self Tolerance; T-Lymphocytes | 2004 |
Free amino acid composition of quince (Cydonia oblonga Miller) fruit (pulp and peel) and jam.
Topics: Amino Acids; Asparagine; Aspartic Acid; Chromatography, Gas; Fruit; Glycine; Hydroxyproline; Rosaceae | 2004 |
Proton uptake upon anaerobic reduction of the Paracoccus denitrificans cytochrome c oxidase: a kinetic investigation of the K354M and D124N mutants.
Topics: Amino Acid Substitution; Anaerobiosis; Asparagine; Aspartic Acid; Calibration; Electron Transport Complex IV; Heme; Lysine; Methionine; Oxidation-Reduction; Paracoccus denitrificans; Phenolsulfonphthalein; Protein Subunits; Protons; Spectrophotometry | 2004 |
alpha-Tropomyosin mutations Asp(175)Asn and Glu(180)Gly affect cardiac function in transgenic rats in different ways.
Topics: Animals; Animals, Genetically Modified; Asparagine; Aspartic Acid; Biomarkers; Calcium; Cardiomyopathy, Hypertrophic, Familial; Gene Expression; Glutamic Acid; Glycine; Heart; Heart Ventricles; Humans; Immunohistochemistry; In Vitro Techniques; Muscle Fibers, Skeletal; Mutation, Missense; Myocardial Contraction; Myocytes, Cardiac; Rats; Sarcomeres; Transgenes; Tropomyosin | 2004 |
A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.
Topics: Adenosine Triphosphate; Alleles; Antigens, Neoplasm; Asparagine; Aspartic Acid; DNA; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Humans; Hydrolysis; Mutagenesis, Site-Directed; Mutation; Oligonucleotides; Piperazine; Piperazines; Plasmids; Poly-ADP-Ribose Binding Proteins; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Rad52 DNA Repair and Recombination Protein; Saccharomyces | 2004 |
A novel mutation in the second half of the keratin 17 1A domain in a large pedigree with delayed-onset pachyonychia congenita type 2.
Topics: Adenine; Age of Onset; Amino Acid Substitution; Asparagine; Aspartic Acid; Base Sequence; Codon; Female; Guanine; Heterozygote; Humans; Keratins; Male; Middle Aged; Mutation; Nail Diseases; Pedigree; Protein Structure, Tertiary | 2004 |
Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.
Topics: Adenylyl Cyclases; Adrenergic Agonists; Asparagine; Aspartic Acid; Binding Sites; Cells, Cultured; Cyclic AMP; Enzyme Activation; Epinephrine; Humans; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Receptors, Adrenergic, beta-2 | 2004 |
Lysine metabolism is concurrently regulated by synthesis and catabolism in both reproductive and vegetative tissues.
Topics: Arabidopsis; Arabidopsis Proteins; Asparagine; Aspartic Acid; Bacteria; Bacterial Proteins; Cotyledon; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Germination; Hydro-Lyases; Lysine; Membrane Proteins; Methionine; Mutation; Plants, Genetically Modified; RNA Interference; Seeds | 2004 |
Domain structures and roles in bacteriophage HK97 capsid assembly and maturation.
Topics: Asparagine; Aspartic Acid; Capsid; Coliphages; Crystallization; Cysteine; Glutamic Acid; Lysine; Protein Precursors; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Spectrum Analysis, Raman; Tryptophan; Tyrosine; Virus Assembly | 2004 |
A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Animals; Asparagine; Aspartic Acid; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Enzyme Activation; Humans; Models, Molecular; Mutagenesis, Site-Directed; Phosphorylation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-met; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Tyrosine; Ubiquitin; Ubiquitin-Protein Ligases | 2004 |
Comparison between catalase-peroxidase and cytochrome c peroxidase. The role of the hydrogen-bond networks for protein stability and catalysis.
Topics: Archaeal Proteins; Asparagine; Aspartic Acid; Bacterial Proteins; Catalysis; Cyanobacteria; Cytochrome-c Peroxidase; Enzyme Stability; Ferric Compounds; Ferrous Compounds; Haloarcula marismortui; Histidine; Hydrogen Bonding; Mutagenesis, Site-Directed; Peroxidases; Proline; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Tryptophan | 2004 |
A case of childhood Pompe disease demonstrating phenotypic variability of p.Asp645Asn.
Topics: alpha-Glucosidases; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Blotting, Western; Chlorocebus aethiops; COS Cells; DNA Mutational Analysis; Echocardiography, Three-Dimensional; Fibroblasts; Glycogen Storage Disease Type II; Humans; Infant; Male; Muscles; Mutation; Phenotype; Transfection | 2004 |
Association study of personality factors and the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1).
Topics: Adult; Amino Acid Substitution; Asparagine; Aspartic Acid; DNA Primers; Female; Humans; Male; Models, Psychological; Multivariate Analysis; Mutation, Missense; Personality; Receptors, Opioid, mu | 2004 |
Structural evidence of a passive base-flipping mechanism for beta-glucosyltransferase.
Topics: 5-Methylcytosine; Adenine; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Crystallography, X-Ray; Cytosine; DNA; Glucosyltransferases; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Nucleic Acid Conformation; Oligonucleotides; Plasmids; Protein Binding; Protein Conformation; Uridine Diphosphate | 2004 |
Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K+ channels: implication for dimerization of nucleotide-binding domains to induce channel opening.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; ATP-Binding Cassette Transporters; Binding Sites; Dimerization; Glutamic Acid; Glutamine; Humans; Membrane Proteins; Mice; Mutation; Nicorandil; Nucleotides; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Structure, Tertiary; Receptors, Drug; Sodium; Sulfonylurea Receptors | 2004 |
Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates.
Topics: Acyltransferases; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Catalytic Domain; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Codon; Crystallography, X-Ray; Cysteine; Escherichia coli; Evolution, Molecular; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Naphthols; Naphthoquinones; Oxalic Acid; Polyketide Synthases; Protein Conformation; Protein Structure, Tertiary; Serine; Streptomyces; Streptomyces coelicolor | 2004 |
Does the aspartic acid to asparagine substitution at position 76 in the pancreas duodenum homeobox gene (PDX1) cause late-onset type 2 diabetes?
Topics: Age of Onset; Amino Acid Substitution; Asparagine; Aspartic Acid; Case-Control Studies; Diabetes Mellitus, Type 2; Europe; Female; Homeodomain Proteins; Humans; Insulin; Male; Mutation, Missense; Pedigree; Trans-Activators; United States; White People | 2004 |
A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity.
Topics: Actins; Animals; Apoptosis; Asparagine; Aspartic Acid; Becaplermin; Binding Sites; Cells, Cultured; COS Cells; Dose-Response Relationship, Drug; Enzyme Activation; Fibroblasts; Flow Cytometry; Genetic Vectors; Humans; Kinetics; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Point Mutation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Substrate Specificity; Time Factors; Tyrosine; Up-Regulation; Wound Healing | 2004 |
Early age of onset in fatal familial insomnia. Two novel cases and review of the literature.
Topics: Adult; Age of Onset; Asparagine; Aspartic Acid; DNA Mutational Analysis; Family Health; Genetic Counseling; Glucose; Humans; Immunohistochemistry; Insomnia, Fatal Familial; Male; Methionine; Middle Aged; Neurologic Examination; Pedigree; Postmortem Changes; Prions; Review Literature as Topic; Thalamus; Tomography, Emission-Computed | 2004 |
Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Cell Line; Cell Membrane; Cell Separation; Computational Biology; COS Cells; Cyclic AMP; Cysteine; DNA, Complementary; Dose-Response Relationship, Drug; Epitopes; Flow Cytometry; Humans; Interleukin-8; Microscopy, Confocal; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Peptides; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Thyrotropin; Serine; Signal Transduction; Time Factors; Transfection | 2004 |
Neurotransmitter amino acid in cerebrospinal fluid of patients with dementia with Lewy bodies.
Topics: Age Factors; Age of Onset; Aged; Asparagine; Aspartic Acid; Body Mass Index; Brain; Cerebrospinal Fluid; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Lewy Body Disease; Male; Neuropsychological Tests; Neurotransmitter Agents | 2005 |
Structure of Escherichia coli YhdH, a putative quinone oxidoreductase.
Topics: Amino Acid Sequence; Arginine; Asparagine; Aspartic Acid; Catalytic Domain; Cloning, Molecular; Crystallography, X-Ray; Dimerization; Electron Transport Complex I; Escherichia coli; Escherichia coli Proteins; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Quinone Reductases; Sequence Homology, Amino Acid; Thermus thermophilus | 2004 |
Utilization of aspartic acid and asparagine by yeast.
Topics: Acids; Asparagine; Aspartic Acid; Humans; Saccharomyces cerevisiae; Yeasts | 1950 |
Plasma protein aspartyl damage is increased in hemodialysis patients: studies on causes and consequences.
Topics: Asparagine; Aspartic Acid; Biomarkers; Blood Chemical Analysis; Blood Proteins; Diazepam; Female; Humans; In Vitro Techniques; Kidney Failure, Chronic; Male; Prognosis; Protein Binding; Renal Dialysis; Risk Assessment; Salicylates; Sampling Studies; Sensitivity and Specificity; Warfarin | 2004 |
Role of charged residues of pharaonis phoborhodopsin (sensory rhodopsin II) in its interaction with the transducer protein.
Topics: Amino Acid Sequence; Archaeal Proteins; Asparagine; Aspartic Acid; Carotenoids; Halorhodopsins; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Natronobacterium; Photolysis; Photoreceptors, Microbial; Protein Binding; Sensory Rhodopsins; Signal Transduction; Static Electricity | 2004 |
Structural and biochemical implications of single amino acid substitutions in the nucleotide-dependent switch regions of the nitrogenase Fe protein from Azotobacter vinelandii.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Asparagine; Aspartic Acid; Azotobacter vinelandii; Electron Transport; Hydrogen Bonding; Magnesium; Nucleotides; Oxidoreductases; Protein Conformation; Protein Structure, Secondary; Static Electricity; X-Ray Diffraction | 2004 |
Striking PrPsc heterogeneity in inherited prion diseases with the D178N mutation.
Topics: Asparagine; Aspartic Acid; Brain; Humans; Mutation; Prion Diseases; PrPSc Proteins | 2004 |
Substitution of a single residue, Asp575, renders the NCKX2 K+-dependent Na+/Ca2+ exchanger independent of K+.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Biological Transport; Calcium; Cell Line; Electrophysiology; Humans; Kinetics; Patch-Clamp Techniques; Potassium; Sodium-Calcium Exchanger | 2005 |
Crystal structures and amidolytic activities of two glycosylated snake venom serine proteinases.
Topics: Agkistrodon; Amino Acid Sequence; Amyloid; Animals; Asparagine; Aspartic Acid; Base Sequence; Binding Sites; Carbohydrates; Crystallography, X-Ray; DNA, Complementary; Glycosylation; Kinetics; Models, Molecular; Molecular Sequence Data; Monosaccharides; Mutagenesis, Site-Directed; Oligosaccharides; Protein Conformation; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Serine Endopeptidases; Snake Venoms; Species Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trimeresurus; Trypsin; Trypsin Inhibitor, Kunitz Soybean | 2005 |
Identification of functional amino acids in the Nramp family by a combination of evolutionary analysis and biophysical studies of metal and proton cotransport in vivo.
Topics: Amino Acids; Asparagine; Aspartic Acid; Cadmium; Cation Transport Proteins; Cell Membrane Permeability; Cobalt; Escherichia coli Proteins; Evolution, Molecular; Ferrous Compounds; Histidine; Manganese; Metals, Heavy; Mutagenesis, Site-Directed; Protein Transport; Proto-Oncogene Proteins c-myc; Protons | 2005 |
Structural characterization of NETNES, a novel glycoconjugate in Trypanosoma cruzi epimastigotes.
Topics: Algorithms; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Carbohydrate Conformation; Carbohydrate Sequence; Chromatography; Chromatography, High Pressure Liquid; Databases as Topic; Electrophoresis, Polyacrylamide Gel; Glycoconjugates; Glycoproteins; Glycoside Hydrolases; Glycosylphosphatidylinositols; Hydrofluoric Acid; Hydrolysis; Ions; Mannose; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mass Spectrometry; Methylation; Models, Chemical; Molecular Sequence Data; Nitrous Acid; Peptides; Phospholipids; Phosphorylation; Polysaccharides; Protein Processing, Post-Translational; Protein Sorting Signals; Protein Structure, Tertiary; Protozoan Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Trypanosoma cruzi | 2005 |
Evidence for a novel racemization process of an asparaginyl residue in mouse lysozyme under physiological conditions.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Mice; Molecular Sequence Data; Muramidase; Peptides; Stereoisomerism; Time Factors | 2005 |
Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway.
Topics: Alanine; Amidohydrolases; Asparagine; Aspartic Acid; Bacterial Proteins; Glutamic Acid; Gram-Negative Bacteria; Histidine; Hydrogen-Ion Concentration; Kinetics; Lipid A; Lysine; Mutagenesis, Site-Directed; Substrate Specificity; Zinc | 2005 |
Effects of acidic N + 1 residues on asparagine deamidation rates in solution and in the solid state.
Topics: Amides; Asparagine; Aspartic Acid; Drug Stability; Hydrogen-Ion Concentration; Oligopeptides; Pharmaceutical Solutions | 2005 |
Active site rearrangement of the 2-hydrazinopyridine adduct in Escherichia coli amine oxidase to an azo copper(II) chelate form: a key role for tyrosine 369 in controlling the mobility of the TPQ-2HP adduct.
Topics: Amine Oxidase (Copper-Containing); Asparagine; Aspartic Acid; Azo Compounds; Binding Sites; Cations, Divalent; Chelating Agents; Cobalt; Copper; Crystallography, X-Ray; Enzyme Inhibitors; Enzyme Stability; Escherichia coli Proteins; Glutamic Acid; Hydrogen-Ion Concentration; Mutagenesis, Site-Directed; Phenylalanine; Pyridones; Resorcinols; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Tyrosine | 2005 |
Membrane-bound pyrophosphatase of Thermotoga maritima requires sodium for activity.
Topics: Alanine; Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Cations, Monovalent; Enzyme Activation; Escherichia coli; Gene Expression Regulation, Bacterial; Hydrolysis; Inorganic Pyrophosphatase; Intracellular Membranes; Kinetics; Multigene Family; Mutagenesis, Site-Directed; Potassium; Saccharomyces cerevisiae; Sodium; Thermotoga maritima | 2005 |
Synthesis of glycosyl amino acids by light-induced coupling of photoreactive amino acids with glycosylamines and 1-C-aminomethyl glycosides.
Topics: Acylation; Amino Acids; Asparagine; Aspartic Acid; Carbohydrate Conformation; Disaccharides; Glucosides; Glycoconjugates; Glycosides; Glycosylation; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Molecular Structure; Ultraviolet Rays | 2005 |
An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor.
Topics: Alanine; Amino Acid Motifs; Animals; Asparagine; Aspartic Acid; Binding Sites; Cattle; Cell Membrane; Cell Separation; COS Cells; Cyclic AMP; Dose-Response Relationship, Drug; Flow Cytometry; Hydrogen Bonding; Leucine; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Receptors, G-Protein-Coupled; Receptors, Thyrotropin; Rhodopsin; Software; Static Electricity; Threonine; Transfection | 2005 |
Spontaneous chemical reversion of an active site mutation: deamidation of an asparagine residue replacing the catalytic aspartic acid of glutamate dehydrogenase.
Topics: Amides; Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Catalytic Domain; Clostridium; Enzyme Stability; Glutamate Dehydrogenase; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Temperature; Time Factors | 2005 |
Deamidation and disulfide bridge formation in human calbindin D28k with effects on calcium binding.
Topics: Alkylation; Amino Acid Sequence; Asparagine; Aspartic Acid; Calbindin 1; Calbindins; Calcium; Cysteine; Electrophoresis, Agar Gel; Humans; Mass Spectrometry; Molecular Sequence Data; Protein Processing, Post-Translational; S100 Calcium Binding Protein G | 2005 |
Functional analysis of the human variants of breast cancer resistance protein: I206L, N590Y, and D620N.
Topics: Alleles; Amino Acid Substitution; Antineoplastic Agents; Asparagine; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Genetic Variation; Humans; Isoleucine; Leucine; Neoplasm Proteins; Polymorphism, Single Nucleotide; Transfection; Tyrosine | 2005 |
Novel compound heterozygous mutations in the PANK2 gene in a Chinese patient with atypical pantothenate kinase-associated neurodegeneration.
Topics: Adult; Asian People; Asparagine; Aspartic Acid; DNA Mutational Analysis; Exons; Glycine; Heterozygote; Humans; Isoleucine; Magnetic Resonance Imaging; Male; Mutation; Pantothenate Kinase-Associated Neurodegeneration; Phosphotransferases (Alcohol Group Acceptor) | 2005 |
Hinge residue Ile260 of DNA polymerase beta is important for enzyme activity and fidelity.
Topics: Amino Acid Substitution; Animals; Arginine; Asparagine; Aspartic Acid; DNA Polymerase beta; Enzyme Activation; Enzyme Stability; Escherichia coli Proteins; Genetic Complementation Test; Genetic Variation; Glutamic Acid; Glutamine; Histidine; Isoleucine; Lysine; Peptide Fragments; Phenotype; Protein Folding; Protein Structure, Tertiary; Rats; Substrate Specificity | 2005 |
Aspartate 120 of Escherichia coli methylenetetrahydrofolate reductase: evidence for major roles in folate binding and catalysis and a minor role in flavin reactivity.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Alanine; Asparagine; Aspartic Acid; Catalysis; Cold Temperature; Escherichia coli Proteins; Flavin-Adenine Dinucleotide; Folic Acid; Imines; Kinetics; Lysine; Mutagenesis, Site-Directed; NAD; Oxidation-Reduction; Potentiometry; Spectrophotometry; Substrate Specificity; Thermodynamics | 2005 |
Point mutations at the type I Cu ligands, Cys457 and Met467, and at the putative proton donor, Asp105, in Myrothecium verrucaria bilirubin oxidase and reactions with dioxygen.
Topics: Alanine; Amino Acid Substitution; Asparagine; Aspartic Acid; Copper; Cysteine; Dithionite; Fungal Proteins; Glutamic Acid; Glutamine; Hypocreales; Ligands; Methionine; Oxidation-Reduction; Oxidoreductases Acting on CH-CH Group Donors; Oxygen; Point Mutation; Protons; Serine | 2005 |
Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli.
Topics: Asparagine; Aspartic Acid; Binding Sites; Catalysis; Crystallography, X-Ray; Dipeptidases; Escherichia coli Proteins; Hydrogen-Ion Concentration; Isoaspartic Acid; Kinetics; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Protons; Substrate Specificity | 2005 |
Engineering dihydropteroate synthase (DHPS) for efficient expression on M13 phage.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Bacteriophage M13; Cysteine; Dihydropteroate Synthase; Immunoassay; Mutation; Peptide Library; Periplasm; Periplasmic Proteins; Protein Engineering | 2005 |
Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex.
Topics: Animals; Antigens, CD; Asparagine; Aspartic Acid; Binding Sites; Carrier Proteins; Cell Membrane; Chromatography, Affinity; Chromatography, Gel; DNA Mutational Analysis; Galactosylceramides; Glycolipids; Humans; Lactosylceramides; Leucine; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Phenylalanine; Phosphatidylcholines; Point Mutation; Protein Binding; Recombinant Fusion Proteins; Swine; Time Factors; Tryptophan | 2005 |
Calcium-binding proteins afford calibration of dihedral-angle dependence of 3J(NC(gamma)) coupling constant in aspartate and asparagine residues.
Topics: Asparagine; Aspartic Acid; Calcium-Binding Proteins; Calibration; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation | 2005 |
Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveals two related signature sequences harboring highly conserved aspartic acids critical for sodium-dependent phosphate transport function of human PiT2.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Bacterial Proteins; Biological Transport; Carrier Proteins; Cells, Cultured; CHO Cells; Conserved Sequence; Cricetinae; Cricetulus; Evolution, Molecular; Female; Humans; Leukemia Virus, Murine; Membrane Proteins; Molecular Sequence Data; Multigene Family; Mutation; Oocytes; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type III; Symporters | 2005 |
Restricted variable residues in the C-terminal segment of HIV-1 V3 loop regulate the molecular anatomy of CCR5 utilization.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; CD4-Positive T-Lymphocytes; Chemokine CCL5; Gene Products, env; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Molecular Sequence Data; Mutation; Proline; Protein Structure, Tertiary; Receptors, CCR5 | 2005 |
Lennard-Jones parameters for the combined QM/MM method using the B3LYP/6-31G*/AMBER potential.
Topics: Acetamides; Amino Acids; Asparagine; Aspartic Acid; Computer Simulation; Histidine; Hydrogen Bonding; Lysine; Models, Molecular; Molecular Structure; Proteins; Serine; Thermodynamics | 2005 |
Identification of residues essential for carbohydrate recognition and cation dependence of the 46-kDa mannose 6-phosphate receptor.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Carbohydrate Metabolism; Cations; Cattle; Dogs; Electron Spin Resonance Spectroscopy; Glucuronidase; Histidine; Humans; Lectins; Lysosomes; Manganese; Mice; Molecular Sequence Data; Rats; Receptors, Cell Surface; Surface Plasmon Resonance; Time Factors | 2005 |
A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.
Topics: Animals; Asparagine; Aspartic Acid; Binding Sites; Cattle; Drug Design; Hydrogen Bonding; Models, Molecular; Protein Conformation; Receptors, Serotonin; Rhodopsin; Serine; Serotonin Antagonists | 2005 |
Structural basis for the changed substrate specificity of Drosophila melanogaster deoxyribonucleoside kinase mutant N64D.
Topics: Animals; Asparagine; Aspartic Acid; Crystallography, X-Ray; Drosophila melanogaster; Kinetics; Models, Molecular; Mutation; Phosphotransferases (Alcohol Group Acceptor); Protein Structure, Tertiary; Substrate Specificity; Thymine Nucleotides | 2005 |
Change in content of sugars and free amino acids in potato tubers under short-term storage at low temperature and the effect on acrylamide level after frying.
Topics: Acrylamide; Amino Acids; Asparagine; Aspartic Acid; Carbohydrate Metabolism; Chromatography, High Pressure Liquid; Cold Temperature; Color; Cooking; Food Handling; Food Preservation; Fructose; Glucose; Glutamic Acid; Glutamine; Solanum tuberosum; Time Factors | 2005 |
pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum.
Topics: Alleles; Animals; Antimalarials; Artemisinins; Asparagine; Aspartic Acid; ATP-Binding Cassette Transporters; Drug Resistance; Mefloquine; Phenanthrenes; Plasmodium falciparum; Point Mutation; Protozoan Proteins; Quinine; Sesquiterpenes | 2005 |
Lineage-specific variations of congruent evolution among DNA sequences from three genomes, and relaxed selective constraints on rbcL in Cryptomonas (Cryptophyceae).
Topics: Asparagine; Aspartic Acid; Bayes Theorem; Codon; Cryptophyta; Cysteine; DNA; DNA, Ribosomal; Evolution, Molecular; Genome; Histidine; Likelihood Functions; Phenylalanine; Photosynthesis; Phylogeny; Plastids; Polymerase Chain Reaction; Ribulose-Bisphosphate Carboxylase; Sequence Analysis, DNA; Tyrosine | 2005 |
A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Blotting, Western; Cell Membrane; Cell Proliferation; Cell Transformation, Neoplastic; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Activation; Fibroblasts; Humans; Immunoprecipitation; Ligands; Mice; Molecular Sequence Data; Mutation; Neovascularization, Pathologic; NIH 3T3 Cells; Phosphorylation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Thymidine; Time Factors; Tyrosine; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2006 |
Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism.
Topics: Adolescent; Adult; Amino Acid Substitution; Asparagine; Aspartic Acid; Cation Transport Proteins; Child; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Mycobacterium Infections, Nontuberculous; Mycobacterium ulcerans; Polymorphism, Genetic; Skin Ulcer | 2006 |
Mechanistic pathways of formation of acrylamide from different amino acids.
Topics: Acrylamide; Acrylamides; Acrylates; Amino Acids; Ammonia; Asparagine; Aspartic Acid; beta-Alanine; Carbohydrates; Carnosine; Creatine; Cysteine; Fructose; Gas Chromatography-Mass Spectrometry; Hydrolysis; Mass Spectrometry; Models, Chemical; Pyruvic Acid; Serine; Time Factors | 2005 |
Neuromodulation of Na+ channel slow inactivation via cAMP-dependent protein kinase and protein kinase C.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Cell Line; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Dose-Response Relationship, Radiation; Electric Stimulation; Enzyme Inhibitors; Humans; Ion Channel Gating; Membrane Potentials; Models, Biological; Molecular Biology; Mutagenesis; NAV1.2 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Nucleotides, Cyclic; Patch-Clamp Techniques; Protein Kinase C; Protein Structure, Tertiary; Reaction Time; Sodium Channels; Transfection | 2006 |
The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.
Topics: Adenocarcinoma; Aged; Amino Acid Substitution; Asparagine; Aspartic Acid; Carcinoma, Pancreatic Ductal; Case-Control Studies; Female; Gene Frequency; Genotype; Glutamine; Haplotypes; Humans; Linkage Disequilibrium; Lysine; Male; Middle Aged; Pancreatic Neoplasms; Polymorphism, Single Nucleotide; Risk Factors; Smoking; Xeroderma Pigmentosum Group D Protein | 2007 |
Correlation between AS1 gene expression and seed protein contents in different soybean (Glycine max [L.] Merr.) cultivars.
Topics: Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Glycine max; Seedlings; Seeds | 2006 |
The Duarte (N314D) variant in the GALT gene has no effect on in vitro fertilization outcome.
Topics: Adult; Arginine; Asparagine; Aspartic Acid; Case-Control Studies; Female; Fertilization; Fertilization in Vitro; Gene Frequency; Genetic Variation; Genotype; Glutamine; Humans; Infertility; Mutation; Pregnancy; Pregnancy Rate; Treatment Outcome; UDPglucose-Hexose-1-Phosphate Uridylyltransferase | 2006 |
Molecular dynamics simulations show that bound Mg2+ contributes to amino acid and aminoacyl adenylate binding specificity in aspartyl-tRNA synthetase through long range electrostatic interactions.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Aminoacylation; Archaeal Proteins; Asparagine; Aspartate-tRNA Ligase; Aspartic Acid; Binding Sites; Catalysis; Cations, Divalent; Computer Simulation; Crystallography, X-Ray; Enzyme Stability; Magnesium; Pyrococcus; RNA, Transfer; Static Electricity; Substrate Specificity; Thermodynamics | 2006 |
Aspartic acid 214 in Citrobacter freundii tyrosine phenol-lyase ensures sufficient C--H-acidity of the external aldimine intermediate and proper orientation of the cofactor at the active site.
Topics: Alanine; Apoenzymes; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Circular Dichroism; Citrobacter freundii; Coenzymes; Deuterium Oxide; Homoserine; Kinetics; Molecular Structure; Mutation; Phenylalanine; Recombinant Fusion Proteins; Spectrophotometry; Tyrosine; Tyrosine Phenol-Lyase | 2006 |
EPR spectroscopy and theoretical study of gamma-irradiated asparagine and aspartic acid in solid state.
Topics: Asparagine; Aspartic Acid; Decarboxylation; Electron Spin Resonance Spectroscopy; Free Radicals; Gamma Rays; Molecular Conformation | 2007 |
DNA-repair gene polymorphisms predict favorable clinical outcome among patients with advanced squamous cell carcinoma of the head and neck treated with cisplatin-based induction chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Alanine; Antineoplastic Combined Chemotherapy Protocols; Arginine; Asparagine; Aspartic Acid; Carcinoma, Squamous Cell; Cisplatin; Cysteine; DNA Repair; DNA-Binding Proteins; DNA, Neoplasm; Endonucleases; Female; Gene Frequency; Genotype; Glutamine; Head and Neck Neoplasms; Humans; Lysine; Male; Middle Aged; Multivariate Analysis; Neoplasm Staging; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Survival Analysis; Treatment Outcome; X-ray Repair Cross Complementing Protein 1; Xeroderma Pigmentosum Group D Protein | 2006 |
N-phosphonacetyl-L-isoasparagine a potent and specific inhibitor of Escherichia coli aspartate transcarbamoylase.
Topics: Asparagine; Aspartate Carbamoyltransferase; Aspartic Acid; Binding Sites; Crystallography, X-Ray; Escherichia coli; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Structure; Organophosphonates; Phosphonoacetic Acid | 2006 |
Asp92Asn polymorphism in the myeloid IgA Fc receptor is associated with myocardial infarction in two disparate populations: CARE and WOSCOPS.
Topics: Alleles; Anticholesteremic Agents; Antigens, CD; Asparagine; Aspartic Acid; Coronary Disease; Genetic Predisposition to Disease; Genotype; Humans; Male; Myocardial Infarction; Odds Ratio; Polymorphism, Single Nucleotide; Pravastatin; Receptors, Fc; Risk Factors; Scotland | 2006 |
Asn- and Asp-mediated interactions between transmembrane helices during translocon-mediated membrane protein assembly.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Dimerization; Dogs; Hydrogen Bonding; Membrane Proteins; Models, Biological; Molecular Sequence Data; Pancreas; Peptide Hydrolases; Protein Biosynthesis; Protein Structure, Secondary | 2006 |
Catalytic site modifications of TAP1 and TAP2 and their functional consequences.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP Binding Cassette Transporter, Subfamily B, Member 3; ATP-Binding Cassette Transporters; Baculoviridae; Binding Sites; Catalytic Domain; Cell Line, Tumor; Genetic Vectors; Glutamic Acid; Glutamine; Histidine; Humans; Nucleotides; Protein Transport | 2006 |
Replacing Asn207 by aspartate at the neck of the D channel in the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides results in decoupling the proton pump.
Topics: Asparagine; Aspartic Acid; Electron Transport Complex IV; Electrophoresis, Polyacrylamide Gel; Mutation; Proton Pumps; Rhodobacter sphaeroides; Spectrophotometry, Ultraviolet | 2006 |
Of folding and function: understanding active-site context through metalloenzyme design.
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Calcium; Circular Dichroism; DNA; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Glutamic Acid; Helix-Turn-Helix Motifs; Hydrolysis; Kinetics; Lanthanoid Series Elements; Metalloproteins; Molecular Sequence Data; Phosphates; Protein Folding; Substrate Specificity | 2006 |
The role of N286 and D320 in the reaction mechanism of human dihydrolipoamide dehydrogenase (E3) center domain.
Topics: Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Catalysis; Crystallography, X-Ray; Dihydrolipoamide Dehydrogenase; Dimerization; Flavin-Adenine Dinucleotide; Humans; Kinetics; Molecular Sequence Data; Mutation; Protein Structure, Tertiary | 2007 |
Mutagenesis and modeling of the peroxiredoxin (Prx) complex with the NMR structure of ATP-bound human sulfiredoxin implicate aspartate 187 of Prx I as the catalytic residue in ATP hydrolysis.
Topics: Adenosine Triphosphate; Asparagine; Aspartic Acid; Catalysis; Crystallography, X-Ray; Cysteine; Humans; Hydrolysis; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; Peroxiredoxins; Protein Structure, Tertiary | 2006 |
Conformational coupling between the cytoplasmic carboxylic acid and the retinal in a fungal light-driven proton pump.
Topics: Amino Acid Substitution; Ascomycota; Asparagine; Aspartic Acid; Carboxylic Acids; Cytoplasm; Glutamic Acid; Lasers; Neurospora; Protein Conformation; Proton Pumps; Retinaldehyde; Rhodopsin | 2006 |
A potential pitfall in 18O-based N-linked glycosylation site mapping.
Topics: alpha-Fetoproteins; Animals; Asparagine; Aspartic Acid; Cattle; Glycosylation; Oxygen Isotopes; Peptide Mapping; Protein Processing, Post-Translational; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Trypsin | 2007 |
A novel FKRP mutation in congenital muscular dystrophy disrupts the dystrophin glycoprotein complex.
Topics: Asparagine; Aspartic Acid; Child, Preschool; Dystrophin; Female; Glycoproteins; Humans; Muscular Dystrophies; Mutation; Pentosyltransferases; Proteins | 2007 |
Cleavage of a bacterial autotransporter by an evolutionarily convergent autocatalytic mechanism.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Catalysis; Conserved Sequence; Detergents; DNA Mutational Analysis; Escherichia coli; Escherichia coli O157; Evolution, Molecular; Models, Biological; Molecular Sequence Data; Protein Precursors; Protein Processing, Post-Translational; Protein Structure, Tertiary; Solutions; Succinimides | 2007 |
Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly.
Topics: Abnormalities, Multiple; Adolescent; Adult; Amino Acid Sequence; Asparagine; Aspartic Acid; Autistic Disorder; Child; Child, Preschool; Craniofacial Abnormalities; DNA Mutational Analysis; Exons; Female; Genetic Testing; Humans; Introns; Male; Molecular Sequence Data; Mutation; PTEN Phosphohydrolase; Syndrome | 2007 |
Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase.
Topics: Adenosine Diphosphate; Asparagine; Aspartic Acid; Catalytic Domain; Humans; Isocitrate Dehydrogenase; Mutagenesis, Site-Directed; NAD; Protein Subunits; Structure-Activity Relationship; Substrate Specificity | 2007 |
The crystal structure of the ring-hydroxylating dioxygenase from Sphingomonas CHY-1.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Catalytic Domain; Crystallization; Crystallography, X-Ray; Dioxygenases; Iron-Sulfur Proteins; Models, Molecular; Molecular Sequence Data; Protein Structure, Quaternary; Sequence Alignment; Sphingomonas; Water | 2007 |
Multiple asparagine deamidation of Bacillus anthracis protective antigen causes charge isoforms whose complexity correlates with reduced biological activity.
Topics: Amino Acid Sequence; Antigens, Bacterial; Asparagine; Aspartic Acid; Bacillus anthracis; Bacterial Proteins; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Protein Isoforms; Protein Processing, Post-Translational; Recombinant Proteins | 2007 |
Polymorphisms in XPD (Asp312Asn and Lys751Gln) genes, sunburn and arsenic-related skin lesions.
Topics: Adult; Amino Acid Substitution; Arsenic; Asparagine; Aspartic Acid; Case-Control Studies; Female; Genetic Predisposition to Disease; Glutamine; Humans; Lysine; Male; Polymorphism, Single Nucleotide; Skin Diseases; Sunburn; Water Supply; Xeroderma Pigmentosum Group D Protein | 2007 |
Recurrence of the D100N mutation in a Chinese family with brachydactyly type A1: evidence for a mutational hot spot in the Indian hedgehog gene.
Topics: Asian People; Asparagine; Aspartic Acid; Base Sequence; China; Female; Hedgehog Proteins; Humans; Limb Deformities, Congenital; Male; Molecular Sequence Data; Mutation; Pedigree; Radiography | 2007 |
Identification of deamidation and isomerization sites on pharmaceutical recombinant antibody using H(2)(18)O.
Topics: Amides; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Asparagine; Aspartic Acid; Binding Sites; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Humans; Isomerism; Mass Spectrometry; Molecular Sequence Data; Oxygen Isotopes; Peptide Mapping; Recombinant Proteins | 2007 |
Structural basis for recognition of high mannose type glycoproteins by mammalian transport lectin VIP36.
Topics: Animals; Asparagine; Aspartic Acid; Calcium; Carbohydrate Conformation; Carbohydrate Sequence; Carbohydrates; Crystallography, X-Ray; Dogs; Glycoproteins; Histidine; Ligands; Mannose; Mannose-Binding Lectins; Membrane Transport Proteins; Molecular Sequence Data | 2007 |
Mutations in yhiT enable utilization of exogenous pyrimidine intermediates in Salmonella enterica serovar Typhimurium.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Bacterial Proteins; Base Sequence; Carrier Proteins; Cloning, Molecular; Escherichia coli; Genes, Bacterial; Malates; Membrane Proteins; Molecular Sequence Data; Mutation; Operon; Orotic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Salmonella typhimurium; Succinic Acid; Transcription Initiation Site | 2007 |
Lethal contractural syndrome type 3 (LCCS3) is caused by a mutation in PIP5K1C, which encodes PIPKI gamma of the phophatidylinsitol pathway.
Topics: Alleles; Amino Acid Sequence; Amino Acid Substitution; Arthrogryposis; Asparagine; Aspartic Acid; Chromosomes, Human, Pair 19; Female; Homozygote; Humans; Male; Molecular Sequence Data; Mutation; Pedigree; Phosphatidylinositol 4,5-Diphosphate; Phosphotransferases (Alcohol Group Acceptor); Syndrome | 2007 |
Dimerization of a PACAP peptide analogue in DMSO via asparagine and aspartic acid residues.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Chromatography, Gel; Chromatography, High Pressure Liquid; Dimerization; Dimethyl Sulfoxide; Molecular Sequence Data; Pituitary Adenylate Cyclase-Activating Polypeptide; Spectrometry, Mass, Electrospray Ionization | 2008 |
Structural basis for the role of Asp-120 in metallo-beta-lactamases.
Topics: Asparagine; Aspartic Acid; beta-Lactamases; Binding Sites; Crystallography, X-Ray; Moxalactam; Mutant Proteins; Protein Subunits; Solutions; Static Electricity; Stenotrophomonas maltophilia; Zinc | 2007 |
Phenotypic and genotypic analysis of amino acid auxotrophy in Lactobacillus helveticus CNRZ 32.
Topics: Amino Acids; Asparagine; Aspartic Acid; Citric Acid; Genome, Bacterial; Genotype; Lactobacillus helveticus; Models, Biological; Ornithine; Ornithine Decarboxylase; Phenotype; Putrescine | 2008 |
The polymorphisms Asn130Asp and Val174Ala in OATP1B1 and the CYP2C9 allele *3 independently affect torsemide pharmacokinetics and pharmacodynamics.
Topics: Alanine; Alleles; Aryl Hydrocarbon Hydroxylases; Asparagine; Aspartic Acid; Cytochrome P-450 CYP2C9; Humans; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters; Polymorphism, Genetic; Sulfonamides; Torsemide; Valine | 2008 |
Do aspartate and asparagine acute supplementation influence the onset of fatigue in intense exercise?
Topics: Adult; Asparagine; Aspartic Acid; Cross-Over Studies; Double-Blind Method; Exercise; Fatigue; Humans; Italy; Male; Physical Fitness; Placebos | 2007 |
Genome-scale analysis of anti-metabolite directed strain engineering.
Topics: Alanine; Algorithms; Antimetabolites; Asparagine; Aspartic Acid; Cloning, Molecular; Contig Mapping; Escherichia coli; Gene Expression Profiling; Gene Frequency; Genetic Engineering; Genome, Bacterial; Genomic Library; Genomics; Lac Operon; Mutagenesis, Insertional; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Phenotype; Plasmids; Selection, Genetic | 2008 |
A combined approach of mass spectrometry, molecular modeling, and site-directed mutagenesis highlights key structural features responsible for the thermostability of Sulfolobus solfataricus carboxypeptidase.
Topics: Alkylation; Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Carboxypeptidases; Cysteine; Disulfides; Enzyme Activation; Enzyme Stability; Hot Temperature; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Mass Spectrometry; Models, Chemical; Models, Molecular; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Oxidation-Reduction; Pepsin A; Protein Engineering; Protein Structure, Secondary; Protein Subunits; Serine; Sulfolobus solfataricus; Thermodynamics; Trypsin | 2008 |
Specificity of DNA-binding by the FAX-1 and NHR-67 nuclear receptors of Caenorhabditis elegans is partially mediated via a subclass-specific P-box residue.
Topics: Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Caenorhabditis elegans; Caenorhabditis elegans Proteins; DNA, Helminth; Mutation, Missense; Protein Structure, Tertiary; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Response Elements; Sequence Alignment; Sequence Homology, Amino Acid | 2008 |
A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif.
Topics: Amino Acid Motifs; Asparagine; Aspartic Acid; Crystallography, X-Ray; Fibroblast Growth Factor 1; Glycine; Humans; Kinetics; Models, Biological; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Proline; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Temperature | 2008 |
The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis.
Topics: Asparagine; Aspartic Acid; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Male; Multiple Sclerosis; Polymorphism, Single Nucleotide; Receptors, Immunologic; Spain; Statistics, Nonparametric | 2008 |
Experimental and theoretical studies of sodium cation complexes of the deamidation and dehydration products of asparagine, glutamine, aspartic acid, and glutamic acid.
Topics: Amides; Amino Acids; Asparagine; Aspartic Acid; Glutamic Acid; Glutamine; Kinetics; Models, Chemical; Sodium; Thermodynamics; Water | 2008 |
Post-translational modification of cellular proteins during Leishmania donovani differentiation.
Topics: Animals; Asparagine; Aspartic Acid; Cell Differentiation; Chromatography, Liquid; Glutamic Acid; Glycosylation; Histidine; Humans; Leishmania donovani; Macrophages; Mass Spectrometry; Phosphorylation; Protein Processing, Post-Translational; Proteomics | 2008 |
An amino acid at position 142 in nitrilase from Rhodococcus rhodochrous ATCC 33278 determines the substrate specificity for aliphatic and aromatic nitriles.
Topics: Amino Acid Sequence; Amino Acids; Aminohydrolases; Arginine; Asparagine; Aspartic Acid; Catalysis; Glutamic Acid; Kinetics; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Nitriles; Rhodococcus; Sequence Alignment; Substrate Specificity | 2008 |
SO-LAAO, a novel L-amino acid oxidase that enables Streptococcus oligofermentans to outcompete Streptococcus mutans by generating H2O2 from peptone.
Topics: Amino Acid Sequence; Arginine; Asparagine; Aspartic Acid; Glutamine; Hydrogen Peroxide; Isoleucine; L-Amino Acid Oxidase; Molecular Sequence Data; Mutation; Peptones; Sequence Homology, Amino Acid; Streptococcus; Streptococcus mutans; Tryptophan | 2008 |
Uncertain pathogenicity of MSH2 variants N127S and G322D challenges their classification.
Topics: Asparagine; Aspartic Acid; Biliary Tract Neoplasms; Blotting, Western; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Mismatch Repair; DNA-Binding Proteins; Endometrial Neoplasms; Female; Genetic Predisposition to Disease; Germ-Line Mutation; Glycine; Humans; Immunoprecipitation; MutS Homolog 2 Protein; Pancreatic Neoplasms; Serine; Uncertainty | 2008 |
Differential rate constants of racemization of aspartyl and asparaginyl residues in human alpha A-crystallin mutants.
Topics: alpha-Crystallin A Chain; Amino Acid Substitution; Asparagine; Aspartic Acid; Base Sequence; Circular Dichroism; DNA Primers; Humans; In Vitro Techniques; Kinetics; Molecular Chaperones; Multiprotein Complexes; Mutagenesis, Site-Directed; Recombinant Proteins; Spectrometry, Fluorescence; Stereoisomerism | 2008 |
Molecular analysis of the parkin gene in South African patients diagnosed with Parkinson's disease.
Topics: Adolescent; Adult; Aged; Arginine; Asparagine; Aspartic Acid; Cysteine; DNA Mutational Analysis; Exons; Female; Gene Frequency; Heterozygote; Humans; Male; Middle Aged; Parkinson Disease; Point Mutation; Sequence Deletion; South Africa; Ubiquitin-Protein Ligases; Young Adult | 2009 |
Investigation of the influence of different moisture levels on acrylamide formation/elimination reactions using multiresponse analysis.
Topics: Acrylamide; Asparagine; Aspartic Acid; Glucose; Hot Temperature; Kinetics; Maillard Reaction; Solanum tuberosum; Water | 2008 |
Thermodynamics and mechanism of the deamidation of sodium-bound asparagine.
Topics: Amides; Ammonia; Asparagine; Aspartic Acid; Peptides; Protein Processing, Post-Translational; Sodium; Succinic Anhydrides; Tandem Mass Spectrometry; Thermodynamics | 2008 |
Mutational study of the "catalytic tetrad" of DNA topoisomerase IB from the hemoflagellate Leishmania donovani: Role of Asp-353 and Asn-221 in camptothecin resistance.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Base Sequence; Binding Sites; Camptothecin; Catalysis; DNA Primers; DNA Topoisomerases, Type I; Drug Resistance; Enzyme Inhibitors; Flagella; Leishmania donovani; Molecular Sequence Data; Mutagenesis, Site-Directed; Protozoan Proteins; Topoisomerase I Inhibitors | 2008 |
A halorhodopsin-overproducing mutant isolated from an extremely haloalkaliphilic archaeon Natronomonas pharaonis.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Cell Membrane; Gene Expression Regulation, Archaeal; Halobacteriaceae; Halorhodopsins; Mutation | 2008 |
Computational study on nonenzymatic peptide bond cleavage at asparagine and aspartic acid.
Topics: Asparagine; Aspartic Acid; Computer Simulation; Cyclization; Hydrolysis; Imides; Models, Chemical; Molecular Structure; Peptides; Water | 2008 |
Comparison of nitrogen narcosis and helium pressure effects on striatal amino acids: a microdialysis study in rats.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Corpus Striatum; Glutamic Acid; Glutamine; Helium; Inert Gas Narcosis; Male; Microdialysis; Nitrogen; Pressure; Rats; Rats, Sprague-Dawley | 2009 |
Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties.
Topics: Animals; Asparagine; Aspartic Acid; Benztropine; Binding, Competitive; Cell Line, Transformed; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Drug Interactions; Humans; Leucine; Models, Molecular; Mutation; Piperazines; Protein Binding; Protein Structure, Tertiary; Sodium; Structure-Activity Relationship; Transfection; Tritium; Tryptophan | 2008 |
An isocratic fluorescence HPLC assay for the monitoring of l-asparaginase activity and l-asparagine depletion in children receiving E. colil-asparaginase for the treatment of acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Stability; Escherichia coli Proteins; Fluorescence; Glutamic Acid; Glutamine; Homoserine; Humans; Least-Squares Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2009 |
Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality.
Topics: Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Cardiac Output; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Gene Expression Regulation, Developmental; Heart Ventricles; Homozygote; Long QT Syndrome; Mice; Mice, Mutant Strains; Mutation, Missense; Pregnancy; Ventricular Dysfunction, Right | 2008 |
Analyzing the catalytic role of Asp97 in the methionine aminopeptidase from Escherichia coli.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Aminopeptidases; Asparagine; Aspartic Acid; Catalysis; Catalytic Domain; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Glycine; Kinetics; Methionine; Methionyl Aminopeptidases; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Recombinant Proteins; Sequence Alignment; Substrate Specificity | 2008 |
Phenotype-genotype correlations in autosomal dominant retinitis pigmentosa caused by RHO, D190N.
Topics: Adolescent; Adult; Asparagine; Aspartic Acid; Child; Electroretinography; Fluorescence; Fundus Oculi; Genes, Dominant; Genotype; Humans; Male; Middle Aged; Mutation; Pedigree; Phenotype; Retinal Pigment Epithelium; Retinitis Pigmentosa; Rhodopsin; Visual Acuity; Visual Fields; Young Adult | 2008 |
Conserved water mediated H-bonding dynamics of inhibitor, cofactor, Asp 364 and Asn 303 in human IMPDH II.
Topics: Asparagine; Aspartic Acid; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Enzyme Stability; Humans; Hydrogen Bonding; IMP Dehydrogenase; Inosine Monophosphate; Ligands; NAD; Thermodynamics; Water | 2009 |
A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain.
Topics: Alleles; Amino Acid Substitution; Analgesics, Opioid; Asparagine; Aspartic Acid; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expression Regulation; Homozygote; Humans; Pain; Polymorphism, Single Nucleotide; Protein Structure, Tertiary; Receptors, Opioid, mu; Somatosensory Cortex; Thalamus | 2009 |
Deamidation of asparagine residues: direct hydrolysis versus succinimide-mediated deamidation mechanisms.
Topics: Amides; Asparagine; Aspartic Acid; Catalysis; Feasibility Studies; Hydrolysis; Models, Chemical; Models, Molecular; Molecular Conformation; Quantum Theory; Succinimides; Water | 2009 |
Protein residues that control the reaction trajectory in S-adenosylmethionine radical enzymes: mutagenesis of asparagine 153 and aspartate 155 in Escherichia coli biotin synthase.
Topics: Amino Acid Motifs; Asparagine; Aspartic Acid; Biotin; Catalysis; Escherichia coli; Escherichia coli Proteins; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; S-Adenosylmethionine; Sulfurtransferases | 2009 |
Sequence signatures in envelope protein may determine whether flaviviruses produce hemorrhagic or encephalitic syndromes.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Encephalitis, Viral; Flavivirus; Hemorrhage; Humans; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Viral Envelope Proteins; Virulence Factors | 2009 |
Effective amino acid composition of seaweeds inducing food preference behaviors in Aplysia kurodai.
Topics: Amino Acids; Animals; Aplysia; Asparagine; Aspartic Acid; Eating; Food Preferences; Glutamic Acid; Glutamine; Jaw; Phaeophyceae; Phenylalanine; Rhodophyta; Taste; Taurine; Ulva | 2009 |
Site-directed mutagenesis, kinetic and inhibition studies of aspartate ammonia lyase from Bacillus sp. YM55-1.
Topics: Amino Acid Substitution; Asparagine; Aspartate Ammonia-Lyase; Aspartic Acid; Bacillus; Bacterial Proteins; Binding Sites; Catalysis; Catalytic Domain; Circular Dichroism; Histidine; Hydrogen-Ion Concentration; Kinetics; Lysine; Malates; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Nitro Compounds; Propionates; Protein Structure, Tertiary; Serine; Substrate Specificity; Threonine | 2009 |
Insights into tRNA-dependent amidotransferase evolution and catalysis from the structure of the Aquifex aeolicus enzyme.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Sequence; Asparagine; Aspartic Acid; Bacteria; Catalysis; Catalytic Domain; Crystallography, X-Ray; Evolution, Molecular; Genetic Complementation Test; Glutamine; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nitrogenous Group Transferases; Protein Structure, Quaternary; RNA, Transfer; Substrate Specificity; Zinc | 2009 |
[Frequencies of the Los Angeles and Duarte galactose-1-phosphate uridyltransferase variant alleles in the Hungarian population].
Topics: Adult; Amino Acid Substitution; Asparagine; Aspartic Acid; Female; Gene Frequency; Genetic Variation; Genetics, Population; Humans; Hungary; Male; Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; UTP-Hexose-1-Phosphate Uridylyltransferase; White People | 2009 |
Role of intramembrane polar residues in the YgfO xanthine permease: HIS-31 and ASN-93 are crucial for affinity and specificity, and ASP-304 and GLU-272 are irreplaceable.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Escherichia coli K12; Escherichia coli Proteins; Evolution, Molecular; Glutamic Acid; Histidine; Membrane Transport Proteins; Models, Biological; Mutation, Missense; Nucleobase Transport Proteins; Protein Structure, Secondary; Substrate Specificity; Xanthine | 2009 |
Asp327Asn polymorphism of sex hormone-binding globulin gene is associated with systemic lupus erythematosus incidence.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Case-Control Studies; Estradiol; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Incidence; Lupus Erythematosus, Systemic; Poland; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Premenopause; Sex Hormone-Binding Globulin; Testosterone | 2010 |
How can an inert gas counterbalance a NMDA-induced glutamate release?
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Asparagine; Aspartic Acid; Catheters, Indwelling; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Glutamine; Homovanillic Acid; Inert Gas Narcosis; Male; Microdialysis; N-Methylaspartate; Nitrogen; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Statistics, Nonparametric | 2009 |
Resistance mechanism revealed by crystal structures of unliganded nelfinavir-resistant HIV-1 protease non-active site mutants N88D and N88S.
Topics: Asparagine; Aspartic Acid; Carbamates; Catalytic Domain; Crystallography, X-Ray; Drug Resistance, Viral; Furans; HIV Protease; HIV Protease Inhibitors; Humans; Hydrogen Bonding; Mutation; Nelfinavir; Sulfonamides | 2009 |
Primary reaction of sensory rhodopsin II mutant D75N and the influence of azide.
Topics: Asparagine; Aspartic Acid; Azides; Bacteriorhodopsins; Cytoplasm; Electron Spin Resonance Spectroscopy; Halobacteriaceae; Halorhodopsins; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Mutation; Protons; Schiff Bases; Sensory Rhodopsins | 2009 |
Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice.
Topics: Animals; Arginine; Asparagine; Aspartic Acid; Behavior, Animal; Binding Sites; Carrier Proteins; D-Amino-Acid Oxidase; Female; Glycine; Male; Mice; Mutation; Nerve Tissue Proteins; Nervous System; Phenotype; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Serine; Social Behavior; Stereoisomerism | 2010 |
The effect of 5 days of aspartate and asparagine supplementation on glucose transport activity in rat muscle.
Topics: Animals; Asparagine; Aspartic Acid; Biological Transport; Dietary Supplements; Glucose; Glycogen; Insulin; Male; Muscle, Skeletal; Random Allocation; Rats; Rats, Wistar | 2009 |
ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study.
Topics: Aged; Asparagine; Aspartic Acid; Case-Control Studies; Female; Greece; Humans; Male; Middle Aged; Myocardial Infarction; Polymorphism, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins | 2009 |
Side chain: backbone projections in aromatic and ASX residues from NMR cross-correlated relaxation.
Topics: Amino Acids, Aromatic; Asparagine; Aspartic Acid; Computer Simulation; Humans; Nuclear Magnetic Resonance, Biomolecular; Ubiquitin | 2010 |
A missense mutation in the P2RY5 gene leading to autosomal recessive woolly hair in a Syrian patient.
Topics: Adolescent; Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Genes, Recessive; Hair Diseases; Homozygote; Humans; Molecular Sequence Data; Mutation, Missense; Receptors, Purinergic P2; Syria | 2010 |
Discordant clinicopathologic phenotypes in a Japanese kindred of fatal familial insomnia.
Topics: Asian People; Asparagine; Aspartic Acid; Family Health; Female; Humans; Insomnia, Fatal Familial; Male; Middle Aged; Mutation; Phenotype; Prions; Radionuclide Imaging | 2010 |
A pressurized nitrogen counterbalance to cortical glutamatergic pathway stimulation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Asparagine; Aspartic Acid; Baclofen; Corpus Striatum; Dopamine; Glutamic Acid; Glutamine; Homovanillic Acid; Hyperbaric Oxygenation; Inert Gas Narcosis; Male; Nitrogen; Pressure; Rats; Rats, Sprague-Dawley | 2010 |
Intracerebroventricular injection of L-aspartic acid and L-asparagine induces sedative effects under an acute stressful condition in neonatal chicks.
Topics: Animals; Asparagine; Aspartic Acid; Behavior, Animal; Cerebral Ventricles; Chickens; Hypnotics and Sedatives; Injections; Stress, Psychological; Vocalization, Animal | 2009 |
MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asparagine; Aspartic Acid; Case-Control Studies; Cell Line, Transformed; Cell Line, Tumor; Genetic Predisposition to Disease; Genetic Variation; Humans; Immunophenotyping; Membrane Glycoproteins; Middle Aged; Multicenter Studies as Topic; Myeloid Differentiation Factor 88; NF-kappa B; Point Mutation; Protein Processing, Post-Translational; Protein Transport; Receptors, Interleukin-1; Signal Transduction | 2010 |
Study on amino amides and enzyme kinetics of L-asparaginase by MCE.
Topics: Amides; Asparaginase; Asparagine; Aspartic Acid; Chromatography, Micellar Electrokinetic Capillary; Electrophoresis, Microchip; Escherichia coli; Fluorescein-5-isothiocyanate; Hydrogen-Ion Concentration; Kinetics; Linear Models; Nonlinear Dynamics; Propane; Sensitivity and Specificity; Surface-Active Agents | 2010 |
Enantiospecific adsorption of amino acids on hydroxylated quartz (10 1 0).
Topics: Adsorption; Amino Acids; Asparagine; Aspartic Acid; Cysteine; Quartz; Serine; Stereoisomerism; Thermodynamics | 2010 |
Quantification of structural alterations of L-Asp and L-Asn residues in peptides related to neuronal diseases by reversed-phase high-performance liquid chromatography.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Asparagine; Aspartic Acid; Central Nervous System Diseases; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Molecular Sequence Data; Peptide Fragments; Peptides; Prions; Stereoisomerism; Temperature | 2010 |
A de novo p.Asp18Asn mutation in TREX1 in a patient with Aicardi-Goutières syndrome.
Topics: Adolescent; Amino Acid Substitution; Asparagine; Aspartic Acid; Brain Diseases; DNA; Exodeoxyribonucleases; Female; Genetic Carrier Screening; Humans; Muscle, Skeletal; Mutation; Phosphoproteins; Proteins | 2010 |
Acquisition of Raman spectra of amino acids using portable instruments: outdoor measurements and comparison.
Topics: Alanine; Amino Acids; Asparagine; Aspartic Acid; beta-Alanine; Glutamic Acid; Glutamine; Glycine; Methionine; Proline; Research Design; Robotics; Serine; Spectrum Analysis, Raman; Transportation; Tryptophan; Tyrosine; Workplace | 2010 |
An αIIb mutation in patients with Glanzmann thrombasthenia located in the N-terminus of blade 1 of the β-propeller (Asn2Asp) disrupts a calcium binding site in blade 6.
Topics: Adolescent; Amino Acid Sequence; Animals; Arabs; Asparagine; Aspartic Acid; Binding Sites; Blood Platelets; Calcium; Cell Line; Child; Child, Preschool; Cricetinae; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Glutamine; Hemostasis; Heredity; Humans; Hydrogen Bonding; Integrin alpha2; Integrin beta3; Israel; Leucine; Male; Models, Molecular; Molecular Sequence Data; Mutation; Pedigree; Phenotype; Protein Conformation; Protein Structure, Tertiary; Protein Transport; Thrombasthenia; Transfection | 2011 |
Optimization of the native glucagon sequence for medicinal purposes.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Cell Line; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cyclic AMP; Drug Stability; Genes, Reporter; Glucagon; Glucagon-Like Peptide-1 Receptor; Humans; Hydrogen-Ion Concentration; Hypoglycemia; Isoelectric Point; Molecular Sequence Data; Receptors, Glucagon; Solubility; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Temperature; Transfection | 2010 |
Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.
Topics: Amino Acid Sequence; Ankyrins; Asparagine; Aspartic Acid; Catalytic Domain; Crystallography; Cytoskeleton; HEK293 Cells; Humans; Hydroxylation; Mixed Function Oxygenases; Molecular Sequence Data; Peptide Fragments; Protein Processing, Post-Translational; Protein Stability; Protein Structure, Tertiary; Recombinant Proteins; Repressor Proteins; Signal Transduction | 2011 |
Investigating the structural and functional effects of mutating Asn glycosylation sites of horseradish peroxidase to Asp.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Cytosol; Escherichia coli; Glycosylation; Horseradish Peroxidase; Hydrogen-Ion Concentration; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Spectrometry, Fluorescence; Structure-Activity Relationship | 2011 |
Light-induced movement of the LOV2 domain in an Asp720Asn mutant LOV2-kinase fragment of Arabidopsis phototropin 2.
Topics: Amino Acid Substitution; Arabidopsis; Arabidopsis Proteins; Asparagine; Aspartic Acid; Light; Models, Biological; Models, Molecular; Movement; Mutant Proteins; Peptide Fragments; Phosphotransferases; Protein Conformation; Protein Folding; Protein Structure, Tertiary | 2011 |
Synaptotagmin increases the dynamic range of synapses by driving Ca²+-evoked release and by clamping a near-linear remaining Ca²+ sensor.
Topics: Animals; Animals, Newborn; Asparagine; Aspartic Acid; Auditory Pathways; Brain Stem; Calcium; Cochlear Nucleus; Electric Stimulation; Functional Laterality; Green Fluorescent Proteins; In Vitro Techniques; Mice; Mice, Transgenic; Mutation; Nonlinear Dynamics; Patch-Clamp Techniques; Presynaptic Terminals; Synapses; Synaptic Transmission; Synaptotagmin II | 2011 |
Expression and biochemical characterization of the human enzyme N-terminal asparagine amidohydrolase.
Topics: Amidohydrolases; Animals; Asparagine; Aspartic Acid; Biocatalysis; Circular Dichroism; Cysteine; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Kinetics; Metals; Mice; Models, Chemical; Molecular Structure; Mutation; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity | 2011 |
Biochemical and pathophysiological characterization of Helicobacter pylori asparaginase.
Topics: Animals; Asparaginase; Asparagine; Aspartic Acid; beta-Alanine; Cell Line; Cell Survival; Epithelial Cells; Gene Deletion; Gerbillinae; Helicobacter pylori; Histiocytes; Humans; Hydrogen-Ion Concentration; Immune Evasion; Kinetics; Protein Binding; Virulence; Virulence Factors | 2011 |
Molecular analysis of connexin26 asparagine14 mutations associated with syndromic skin phenotypes.
Topics: Adult; Asparagine; Aspartic Acid; Cell Membrane; Child; Connexin 26; Connexins; Cytoplasm; Endoplasmic Reticulum; Female; Fluoresceins; Gap Junctions; Hearing Loss; HeLa Cells; Humans; Hypertrichosis; Keratoderma, Palmoplantar; Keratosis; Lysine; Male; Mutation, Missense; Nails, Malformed; Protein Transport; Skin; Skin Diseases; Syndrome; Transfection; Tyrosine | 2011 |
Proton-coupled electron transfer in the catalytic cycle of Alcaligenes xylosoxidans copper-dependent nitrite reductase.
Topics: Alcaligenes; Amino Acid Substitution; Asparagine; Aspartic Acid; Catalytic Domain; Copper; Crystallography, X-Ray; Electron Transport; Histidine; Nitrite Reductases; Protons; Recombinant Proteins | 2011 |
A QM/QM investigation of the hUNG2 reaction surface: the untold tale of a catalytic residue.
Topics: Asparagine; Aspartic Acid; Catalysis; Catalytic Domain; Computer Simulation; DNA Mutational Analysis; Glutamic Acid; Histidine; Humans; Models, Molecular; Proline; Protons; Quantum Theory; Static Electricity; Surface Properties; Uracil-DNA Glycosidase; Water | 2011 |
Covalent structural changes in unfolded GroES that lead to amyloid fibril formation detected by NMR: insight into intrinsically disordered proteins.
Topics: Alanine; Amino Acid Sequence; Amyloid; Asparagine; Aspartic Acid; Chaperonin 10; Escherichia coli; Guanidine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Sequence Data; Mutation; Peptides; Protein Binding; Protein Conformation | 2011 |
Pepper asparagine synthetase 1 (CaAS1) is required for plant nitrogen assimilation and defense responses to microbial pathogens.
Topics: Arabidopsis; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Capsicum; Disease Resistance; Disease Susceptibility; Electrolytes; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Gene Library; Gene Silencing; Genes, Plant; Nitric Oxide; Nitrogen; Oomycetes; Plant Diseases; Plant Leaves; Plant Proteins; Plants, Genetically Modified; Pseudomonas syringae; Reactive Oxygen Species; RNA, Plant; Stress, Physiological; Xanthomonas campestris | 2011 |
A novel mutation in the GJA3 (connexin46) gene is associated with autosomal dominant congenital nuclear cataract in a Chinese family.
Topics: Amino Acid Sequence; Asian People; Asparagine; Aspartic Acid; Base Sequence; Cataract; Chromosomes, Human, Pair 13; Connexins; Female; Genes, Dominant; Genetic Linkage; Genotype; Haplotypes; Humans; Lens, Crystalline; Lod Score; Male; Microsatellite Repeats; Molecular Sequence Data; Mutation, Missense; Pedigree | 2011 |
Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula.
Topics: Administration, Oral; Analysis of Variance; Animals; Animals, Newborn; Asparagine; Aspartic Acid; Autoradiography; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; Conditioning, Operant; Electric Stimulation; Green Fluorescent Proteins; Habenula; Humans; In Vitro Techniques; Iodine Isotopes; Mice; Mice, Transgenic; Models, Molecular; Mutation; Nerve Tissue Proteins; Neurons; Nicotine; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Polymorphism, Single Nucleotide; Pyridines; Receptors, Nicotinic; Stereotaxic Techniques; Xenopus | 2011 |
Mutational effects on transglycosylating activity of family 18 chitinases and construction of a hypertransglycosylating mutant.
Topics: Asparagine; Aspartic Acid; Bacterial Proteins; Catalytic Domain; Chitinases; Enzyme Stability; Glycosylation; Hydrolysis; Multigene Family; Mutagenesis, Site-Directed; Oligosaccharides; Point Mutation; Serratia marcescens; Substrate Specificity | 2011 |
[Association between variants of lipoprotein lipase and coronary heart disease in a Tunisian population].
Topics: Aged; Amino Acid Substitution; Asparagine; Aspartic Acid; Case-Control Studies; Coronary Disease; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genetics, Population; Genotype; Humans; Lipoprotein Lipase; Male; Middle Aged; Polymorphism, Single Nucleotide; Serine; Tunisia | 2012 |
Arabidopsis mutants lacking asparaginases develop normally but exhibit enhanced root inhibition by exogenous asparagine.
Topics: Ammonia; Arabidopsis; Arabidopsis Proteins; Asparaginase; Asparagine; Aspartic Acid; DNA, Bacterial; Endosperm; Gene Deletion; Gene Expression Regulation, Plant; Germination; Glucuronidase; Hypocotyl; Isoenzymes; Light; Mutation; Plant Roots; Plants, Genetically Modified | 2012 |
Crystal structure of the archaeal asparagine synthetase: interrelation with aspartyl-tRNA and asparaginyl-tRNA synthetases.
Topics: Adenosine Triphosphate; Ammonia; Asparagine; Aspartate-Ammonia Ligase; Aspartate-tRNA Ligase; Aspartic Acid; Catalytic Domain; Crystallography, X-Ray; Evolution, Molecular; Models, Molecular; Protein Structure, Tertiary; Pyrococcus abyssi; RNA, Transfer, Amino Acyl | 2011 |
Elucidation of degradants in acidic peak of cation exchange chromatography in an IgG1 monoclonal antibody formed on long-term storage in a liquid formulation.
Topics: Animals; Antibodies, Monoclonal; Asparagine; Aspartic Acid; Chemistry, Pharmaceutical; CHO Cells; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Liquid; Chromatography, Reverse-Phase; Complementarity Determining Regions; Cricetinae; Drug Stability; Drug Storage; Glutamine; Glycosylation; Histocompatibility Antigens Class I; Humans; Immunoglobulin G; Isoelectric Focusing; Mass Spectrometry; Peptide Mapping; Receptors, Fc; Temperature; Trypsin | 2012 |
Another evidence for a D47N mutation in GJA8 associated with autosomal dominant congenital cataract.
Topics: Asian People; Asparagine; Aspartic Acid; Case-Control Studies; Cataract; Connexin 26; Connexins; DNA Mutational Analysis; Exons; Eye Proteins; Female; Genes, Dominant; Genetic Linkage; Humans; Male; Models, Molecular; Mutant Proteins; Mutation, Missense; Pedigree; Polymerase Chain Reaction; Thermodynamics | 2011 |
Altering residues N125 and D149 impacts sugar effector binding and allosteric parameters in Escherichia coli lactose repressor.
Topics: Allosteric Regulation; Amino Acid Substitution; Asparagine; Aspartic Acid; DNA-Binding Proteins; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Glycosides; Lac Operon; Lac Repressors; Lactose; Ligands; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Protein Multimerization | 2011 |
The effect of the Asp175Asn and Glu180Gly TPM1 mutations on actin-myosin interaction during the ATPase cycle.
Topics: Actins; Actomyosin; Adenosine Triphosphatases; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Cardiomyopathy, Hypertrophic; Fluorescent Dyes; Glutamic Acid; Glycine; Humans; Muscle Contraction; Mutation; Myosin Subfragments; Naphthalenesulfonates; Peptide Fragments; Protein Structure, Secondary; Rabbits; Spectrometry, Fluorescence; Tropomyosin | 2012 |
[Preparation of L-phenylalanine chiral ligand-exchange chromatographic stationary phase by atom transfer radical polymerization and resolution of racemates].
Topics: Asparagine; Aspartic Acid; Chromatography, Ion Exchange; Ion Exchange Resins; Ligands; Phenylalanine; Polymerization; Stereoisomerism | 2011 |
Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures.
Topics: Amides; Amino Acid Sequence; Animals; Antibodies; Asparagine; Aspartic Acid; CHO Cells; Chromatography, Liquid; Complementarity Determining Regions; Cricetinae; Cricetulus; Hydrogen-Ion Concentration; Immunoglobulin G; Isomerism; Mass Spectrometry; Protein Binding; Recombinant Proteins; Sequence Homology, Amino Acid; Surface Plasmon Resonance; Temperature | 2012 |
Mutagenesis and biochemical studies on AuaA confirmed the importance of the two conserved aspartate-rich motifs and suggested difference in the amino acids for substrate binding in membrane-bound prenyltransferases.
Topics: Amino Acid Motifs; Amino Acids; Asparagine; Aspartic Acid; Blotting, Western; Farnesyltranstransferase; Gene Expression Regulation, Bacterial; Mutagenesis, Site-Directed; Protein Binding; Stigmatella aurantiaca; Substrate Specificity | 2012 |
Asparagine and aspartic acid concentrations in bone marrow versus peripheral blood during Berlin-Frankfurt-Münster-based induction therapy for childhood acute lymphoblastic leukemia.
Topics: Adolescent; Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Aspartic Acid; Bone Marrow; Child; Child, Preschool; Daunorubicin; Drug Administration Schedule; Female; Glutamic Acid; Glutamine; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Time Factors; Treatment Outcome; Vincristine | 2012 |
The asparagine-transamidosome from Helicobacter pylori: a dual-kinetic mode in non-discriminating aspartyl-tRNA synthetase safeguards the genetic code.
Topics: Asparagine; Aspartate-tRNA Ligase; Aspartic Acid; Genetic Code; Helicobacter pylori; Kinetics; Nitrogenous Group Transferases; RNA, Transfer, Asn; RNA, Transfer, Asp; Transfer RNA Aminoacylation | 2012 |
Influence of OPRM1 Asn40Asp variant (A118G) on [11C]carfentanil binding potential: preliminary findings in human subjects.
Topics: Adult; Alcoholism; Asparagine; Aspartic Acid; Carbon Radioisotopes; Female; Fentanyl; Genetic Variation; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Protein Binding; Receptors, Opioid, mu; Young Adult | 2013 |
Vacuolar protein sorting 35 Asp620Asn mutation is rare in the ethnic Chinese population with Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Asparagine; Aspartic Acid; China; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Mutation; Parkinson Disease; Vesicular Transport Proteins | 2012 |
[Alterations of plasma aspartic acid, glycine and asparagine levels in patients with major depressive disorder].
Topics: Adult; Aged; Antidepressive Agents; Asparagine; Aspartic Acid; Depressive Disorder, Major; Female; Glycine; Humans; Male; Middle Aged | 2012 |
Role of side-edge site of sphingomyelinase from Bacillus cereus.
Topics: Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Bacillus cereus; Bacterial Proteins; Erythrocyte Membrane; Glutamic Acid; Magnesium; Molecular Sequence Data; Phenylalanine; Sphingomyelin Phosphodiesterase | 2012 |
A universal surrogate peptide to enable LC-MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc-fusion protein drug candidates in pre-clinical animal studies.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Asparagine; Aspartic Acid; Chromatography, Liquid; Computer Simulation; Dogs; Drug Discovery; Drug Evaluation, Preclinical; Guinea Pigs; Humans; Hydrolysis; Immunoglobulin Fc Fragments; Macaca fascicularis; Macaca mulatta; Mice; Molecular Sequence Data; Peptide Fragments; Rabbits; Rats; Tandem Mass Spectrometry; Trypsin | 2012 |
The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy.
Topics: Actins; Amino Acid Substitution; Asparagine; Aspartic Acid; Calcium; Cardiomyopathy, Hypertrophic; Glutamic Acid; Glycine; Humans; Microscopy, Electron; Models, Chemical; Molecular Dynamics Simulation; Mutation; Myosins; Protein Structure, Secondary; Tropomyosin | 2012 |
Single amino acid exchange in bacteriophage HK620 tailspike protein results in thousand-fold increase of its oligosaccharide affinity.
Topics: Amino Acids; Asparagine; Aspartic Acid; Binding Sites; Catalytic Domain; Coliphages; Crystallography, X-Ray; Glycoside Hydrolases; Hydrogen Bonding; Models, Molecular; O Antigens; Oligosaccharides; Protein Conformation; Surface Properties; Thermodynamics; Viral Tail Proteins | 2013 |
VPS35 mutation in Japanese patients with typical Parkinson's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asian People; Asparagine; Aspartic Acid; Child; Disability Evaluation; Family Health; Female; Genetic Predisposition to Disease; Genetic Testing; Haplotypes; Humans; Male; Middle Aged; Mutation; Parkinson Disease; Vesicular Transport Proteins; Young Adult | 2012 |
Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice.
Topics: Administration, Oral; Androstadienes; Animals; Asparagine; Aspartic Acid; Brain; Female; Insulin; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Knockout; Organ Size; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Processing, Post-Translational; Seizures; Signal Transduction; Wortmannin | 2012 |
Quantitative analysis of deamidation and isomerization in β2-microglobulin by 18O labeling.
Topics: Amides; Amino Acid Sequence; Asparagine; Aspartic Acid; beta 2-Microglobulin; Chromatography, Liquid; Copper; Humans; Molecular Sequence Data; Nanotechnology; Oxygen Isotopes; Peptide Fragments; Stereoisomerism; Succinimides; Tandem Mass Spectrometry | 2012 |
Identification of COL6A2 mutations in progressive myoclonus epilepsy syndrome.
Topics: Adolescent; Adult; Asparagine; Aspartic Acid; Cerebral Cortex; Chromosomes, Human, Pair 21; Collagen Type VI; Consanguinity; Electroencephalography; Female; Homozygote; Humans; Iran; Male; Middle Aged; Mutation; Myoclonic Epilepsies, Progressive; Pedigree; Syndrome | 2013 |
L-asparaginase II produced by Salmonella typhimurium inhibits T cell responses and mediates virulence.
Topics: Ammonia; Animals; Asparaginase; Asparagine; Aspartic Acid; Cell Proliferation; Cytokines; Gene Deletion; Immune Evasion; Mice; Mice, Inbred C57BL; Salmonella typhimurium; T-Lymphocytes; Virulence; Virulence Factors | 2012 |
VPS35 Asp620Asn and EIF4G1 Arg1205His mutations are rare in Parkinson disease from southwest China.
Topics: Adult; Aged; Arginine; Asparagine; Aspartic Acid; Case-Control Studies; China; Eukaryotic Initiation Factor-4G; Female; Histidine; Humans; Male; Middle Aged; Mutation; Parkinson Disease; Vesicular Transport Proteins; Young Adult | 2013 |
Congenital hypomyelinating neuropathy attributable to a de novo p.Asp61Asn mutation of the myelin protein zero gene.
Topics: Asparagine; Aspartic Acid; Charcot-Marie-Tooth Disease; Child, Preschool; Humans; Male; Myelin P0 Protein; Sural Nerve | 2013 |
Cytochrome P450(cin) (CYP176A1) D241N: investigating the role of the conserved acid in the active site of cytochrome P450s.
Topics: Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Biocatalysis; Catalytic Domain; Cyclohexanols; Cytochrome P-450 Enzyme System; Eucalyptol; Hydroxylation; Models, Chemical; Molecular Sequence Data; Molecular Structure; Monoterpenes; Mutant Proteins; Sequence Homology, Amino Acid | 2013 |
Ground state destabilization from a positioned general base in the ketosteroid isomerase active site.
Topics: Alanine; Asparagine; Aspartic Acid; Binding Sites; Catalysis; Catalytic Domain; Comamonas testosteroni; Crystallography, X-Ray; Hydrogen Bonding; Ketosteroids; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Pseudomonas putida; Steroid Isomerases | 2013 |
A quantitative analysis of spontaneous isoaspartate formation from N-terminal asparaginyl and aspartyl residues.
Topics: Alzheimer Disease; Amino Acid Motifs; Amino Acid Sequence; Amyloid beta-Peptides; Asparagine; Aspartic Acid; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Isoaspartic Acid; Isomerism; Kinetics; Plaque, Amyloid; Protein Processing, Post-Translational | 2013 |
TK1656, a thermostable l-asparaginase from Thermococcus kodakaraensis, exhibiting highest ever reported enzyme activity.
Topics: Amino Acid Sequence; Ammonia; Asparaginase; Asparagine; Aspartic Acid; Biocatalysis; Cloning, Molecular; Enzyme Stability; Escherichia coli; Guanidine; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Protein Denaturation; Protein Unfolding; Temperature; Thermococcus; Urea | 2013 |
An 18O-labeling assisted LC/MS method for assignment of aspartyl/isoaspartyl products from Asn deamidation and Asp isomerization in proteins.
Topics: Asparagine; Aspartic Acid; Chromatography, Liquid; Humans; Isomerism; Mass Spectrometry; Oxygen Isotopes; Tandem Mass Spectrometry; Transferrin | 2013 |
A novel type of peptidoglycan-binding domain highly specific for amidated D-Asp cross-bridge, identified in Lactobacillus casei bacteriophage endolysins.
Topics: Amides; Amino Acid Sequence; Asparagine; Aspartic Acid; Bacteriophages; Binding Sites; Catalytic Domain; Cell Wall; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Gram-Positive Bacteria; Lacticaseibacillus casei; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; N-Acetylmuramoyl-L-alanine Amidase; Peptidoglycan; Prophages; Protein Binding; Sequence Homology, Amino Acid; Substrate Specificity | 2013 |
Familial adult-onset Alexander disease with a novel mutation (D78N) in the glial fibrillary acidic protein gene with unusual bilateral basal ganglia involvement.
Topics: Adult; Alexander Disease; Asparagine; Aspartic Acid; Basal Ganglia; DNA Mutational Analysis; Family Health; Female; Glial Fibrillary Acidic Protein; Humans; Japan; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Tomography, X-Ray Computed | 2013 |
An high-performance liquid chromatographic method for the simultaneous analysis of acetylcarnitine taurinate, carnosine, asparagine and potassium aspartate and for the analysis of phosphoserine in alimentary supplements.
Topics: Acetylcarnitine; Asparagine; Aspartic Acid; Carnosine; Chromatography, High Pressure Liquid; Phosphoserine; Reproducibility of Results | 2013 |
Increasing the electron-transfer ability of Cyanidioschyzon merolae ferredoxin by a one-point mutation--a high resolution and Fe-SAD phasing crystal structure analysis of the Asp58Asn mutant.
Topics: Asparagine; Aspartic Acid; Crystallography, X-Ray; Electron Transport; Ferredoxins; Models, Molecular; Mutation; Protein Conformation; Rhodophyta | 2013 |
Effects of asparagine mutagenesis of conserved aspartic acids in helix 2 (D2.50) and 3 (D3.32) of M1-M4 muscarinic receptors on the irreversible binding of nitrogen mustard analogs of acetylcholine and McN-A-343.
Topics: Acetylcholine; Animals; Asparagine; Aspartic Acid; CHO Cells; Cricetinae; Cricetulus; Guinea Pigs; Humans; Kinetics; Mechlorethamine; Mutagenesis; N-Methylscopolamine; Receptors, Muscarinic | 2013 |
Differential effect of D623N variant and wild-type Na(v)1.7 sodium channels on resting potential and interspike membrane potential of dorsal root ganglion neurons.
Topics: Animals; Asparagine; Aspartic Acid; Biophysics; Cells, Cultured; Computer Simulation; Electric Stimulation; Ganglia, Spinal; Green Fluorescent Proteins; Humans; Membrane Potentials; Models, Neurological; Mutation; NAV1.7 Voltage-Gated Sodium Channel; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin; Transfection | 2013 |
Deamidation of asparagine to aspartate destabilizes Cu, Zn superoxide dismutase, accelerates fibrillization, and mirrors ALS-linked mutations.
Topics: Amyotrophic Lateral Sclerosis; Asparagine; Aspartic Acid; Humans; Models, Molecular; Molecular Structure; Mutation, Missense; Protein Stability; Superoxide Dismutase; Superoxide Dismutase-1; Temperature | 2013 |
Determination of allelic expression of SNP rs1880676 in choline acetyltransferase gene in HeLa cells.
Topics: Alleles; Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Choline O-Acetyltransferase; HeLa Cells; Humans; Molecular Sequence Data; Polymorphism, Single Nucleotide; RNA, Messenger | 2013 |
Repeat polymorphisms in the low-complexity regions of Plasmodium falciparum ABC transporters and associations with in vitro antimalarial responses.
Topics: Amino Acid Motifs; Antimalarials; Artemisinins; Asparagine; Aspartic Acid; Chloroquine; Drug Resistance; Ethanolamines; Fluorenes; Gene Expression; Genome, Protozoan; Lumefantrine; Mefloquine; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinine | 2013 |
Importance of polarity of the α4-α5 loop residue-Asn(166) in the pore-forming domain of the Bacillus thuringiensis Cry4Ba toxin: implications for ion permeation and pore opening.
Topics: Aedes; Alanine; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Bacillus thuringiensis; Bacillus thuringiensis Toxins; Bacterial Proteins; Electric Conductivity; Endotoxins; Escherichia coli; Fluoresceins; Hemolysin Proteins; Ion Transport; Isoleucine; Larva; Liposomes; Models, Molecular; Molecular Sequence Data; Permeability; Pest Control, Biological; Protein Structure, Secondary; Recombinant Proteins; Sequence Alignment | 2014 |
Asparagine assimilation is critical for intracellular replication and dissemination of Francisella.
Topics: Amino Acid Transport Systems; Ammonium Compounds; Animals; Asparagine; Aspartic Acid; Bacterial Proteins; Cell Line, Tumor; Francisella tularensis; Hep G2 Cells; Humans; Macrophages; Mice; Mice, Inbred BALB C; Phagosomes; Tularemia | 2014 |
Unexpected reactivity and mechanism of carboxamide activation in bacterial N-linked protein glycosylation.
Topics: Amides; Asparagine; Aspartic Acid; Bacterial Proteins; Binding Sites; Campylobacter jejuni; Campylobacter lari; Escherichia coli; Gene Expression; Glutamine; Glycosylation; Hexosyltransferases; Homoserine; Kinetics; Membrane Proteins; Models, Molecular; Protein Binding; Recombinant Proteins; Substrate Specificity | 2013 |
Comparative analysis of barophily-related amino acid content in protein domains of Pyrococcus abyssi and Pyrococcus furiosus.
Topics: Amino Acid Sequence; Amino Acid Substitution; Archaeal Proteins; Arginine; Asparagine; Aspartic Acid; Evolution, Molecular; Genome, Archaeal; Lysine; Protein Structure, Tertiary; Proteome; Pyrococcus abyssi; Pyrococcus furiosus; Threonine | 2013 |
Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.
Topics: Animals; Asparagine; Aspartic Acid; Disease Models, Animal; Embryo, Mammalian; Endonucleases; Epilepsy; Frameshift Mutation; Gene Targeting; Homologous Recombination; Humans; Mice; Mice, Inbred C57BL; Mutation, Missense; NAV1.6 Voltage-Gated Sodium Channel; Sequence Analysis, DNA | 2014 |
Deciphering the role of aspartate and prephenate aminotransferase activities in plastid nitrogen metabolism.
Topics: Asparagine; Aspartate Aminotransferases; Aspartic Acid; Chlorophyll; Gene Expression Regulation, Plant; Gene Silencing; Glutamic Acid; Lignin; Multigene Family; Nicotiana; Nitrogen; Phenylalanine; Plant Leaves; Plant Proteins; Plastids; Transaminases | 2014 |
Versatile on-resin synthesis of high mannose glycosylated asparagine with functional handles.
Topics: Asparagine; Aspartic Acid; Concanavalin A; Fluorescence; Glycosylation; Mannose; Oligosaccharides; Resins, Synthetic; Solid-Phase Synthesis Techniques | 2014 |
Knockdown of asparagine synthetase A renders Trypanosoma brucei auxotrophic to asparagine.
Topics: Adenosine Triphosphate; Ammonia; Animals; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Disease Models, Animal; Gene Knockdown Techniques; Magnesium; Mice; Mice, Inbred BALB C; Parasitemia; Survival Analysis; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 2013 |
Immediate cooling does not prevent the ex vivo hydrolysis of L-asparagine by asparaginase.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Escherichia coli; Humans; Hydrolysis | 2014 |
A novel beaded filament structural protein 1 (BFSP1) gene mutation associated with autosomal dominant congenital cataract in a Chinese family.
Topics: Adult; Amino Acid Sequence; Amino Acid Substitution; Animals; Asian People; Asparagine; Aspartic Acid; Case-Control Studies; Cataract; Exons; Eye Proteins; Female; Genetic Linkage; Genotype; Humans; Intermediate Filament Proteins; Lens, Crystalline; Male; Molecular Sequence Data; Mutation, Missense; Pedigree; Sequence Alignment; Sequence Analysis, DNA | 2013 |
Mycobacterium tuberculosis MtrAY102C is a gain-of-function mutant that potentially acts as a constitutively active protein.
Topics: Asparagine; Aspartic Acid; ATP-Binding Cassette Transporters; Bacterial Proteins; Cell Membrane; Cell Wall; Escherichia coli; Gene Expression Regulation, Bacterial; Humans; Mutation; Mycobacterium smegmatis; Mycobacterium tuberculosis; Phosphorylation; Promoter Regions, Genetic; RNA-Binding Proteins; Transcription Factors | 2013 |
Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance.
Topics: Amino Acid Sequence; Antibiotics, Antitubercular; Asparagine; Aspartic Acid; DNA-Directed RNA Polymerases; Drug Resistance, Bacterial; Glutamic Acid; Glutamine; Molecular Sequence Data; Mutation; Mycobacterium smegmatis; Phenotype; Protein Biosynthesis; Proteomics; Recombination, Genetic; Rifampin | 2014 |
Metal cation dependence of interactions with amino acids: bond dissociation energies of Rb(+) and Cs(+) to the acidic amino acids and their amide derivatives.
Topics: Asparagine; Aspartic Acid; Cations; Cesium; Computer Simulation; Entropy; Glutamic Acid; Glutamine; Kinetics; Models, Chemical; Potassium; Quantum Theory; Rubidium; Sodium; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Xenon | 2014 |
Computational and experimental studies on β-sheet breakers targeting Aβ1-40 fibrils.
Topics: Amyloid beta-Peptides; Asparagine; Aspartic Acid; Circular Dichroism; Humans; Molecular Dynamics Simulation; Peptide Fragments; Protein Folding; Protein Stability; Protein Structure, Secondary; Taurine | 2014 |
Hydration and conformational equilibrium in yeast thioredoxin 1: implication for H(+) exchange.
Topics: Asparagine; Aspartic Acid; Hydrogen Bonding; Models, Molecular; Molecular Dynamics Simulation; Protein Conformation; Protons; Saccharomyces cerevisiae; Thioredoxins; Water | 2014 |
All-atomic molecular dynamic studies of human CDK8: insight into the A-loop, point mutations and binding with its partner CycC.
Topics: Alanine; Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Cyclin C; Cyclin-Dependent Kinase 8; Gene Expression; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Molecular Sequence Data; Point Mutation; Protein Binding; Protein Stability; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Alignment; Thermodynamics | 2014 |
Spontaneous cyclization of polypeptides with a penultimate Asp, Asn or isoAsp at the N-terminus and implications for cleavage by aminopeptidase.
Topics: Aged; Aged, 80 and over; alpha-Crystallin B Chain; Amino Acid Sequence; Asparagine; Aspartic Acid; Cyclization; Diketopiperazines; Humans; Isoaspartic Acid; Lens, Crystalline; Leucyl Aminopeptidase; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptide Fragments; Peptides, Cyclic; Protein Processing, Post-Translational; Proteolysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Novel complex disease allele mutations in cleidocranial dysplasia patients.
Topics: Adenine; Alleles; Amino Acid Sequence; Asparagine; Aspartic Acid; Case-Control Studies; Cleidocranial Dysplasia; Conserved Sequence; Core Binding Factor Alpha 1 Subunit; Cytosine; Exons; Female; Guanine; Humans; Leucine; Male; Mutation, Missense; Proline; Protein Conformation; Thymine; Tooth, Supernumerary | 2014 |
Investigation of asparagine deamidation in a SOD1-based biosynthetic human insulin precursor by MALDI-TOF mass spectrometry.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Drug Industry; Insulin; Isoaspartic Acid; Metalloendopeptidases; Molecular Sequence Data; Protein Precursors; Quality Control; Serine Endopeptidases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Superoxide Dismutase; Superoxide Dismutase-1 | 2014 |
Amino acid capture and utilization within the Mycobacterium tuberculosis phagosome.
Topics: Amino Acid Transport Systems; Asparagine; Aspartic Acid; Host-Pathogen Interactions; Lysosomes; Macrophages; Mycobacterium tuberculosis; Phagocytosis; Phagosomes; Tuberculosis | 2014 |
Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions.
Topics: Artificial Intelligence; Asparagine; Aspartic Acid; Immunoglobulin Variable Region; Metabolic Networks and Pathways; Models, Molecular; Molecular Conformation; Proteolysis; ROC Curve; Structure-Activity Relationship | 2014 |
Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Aspartic Acid Endopeptidases; Clitoria; Cyclization; Disulfides; Humans; Hydrolysis; Kinetics; Ligases; Macrocyclic Compounds; Models, Molecular; Molecular Sequence Data; Peptide Synthases; Peptides; Plant Proteins; Recombinant Proteins; Substrate Specificity | 2014 |
Mutation strategies for obtaining chitooligosaccharides with longer chains by transglycosylation reaction of family GH18 chitinase.
Topics: Acetylglucosamine; Alanine; Asparagine; Aspartic Acid; Bacterial Proteins; Chitinases; Gene Expression; Glycosylation; Hydrolysis; Molecular Docking Simulation; Mutagenesis, Site-Directed; Mutation; Oligosaccharides; Protein Engineering; Vibrio | 2014 |
Assessing the impact of synchrotron X-ray irradiation on proteinaceous specimens at macro and molecular levels.
Topics: Adhesives; Animals; Asparagine; Aspartic Acid; Color; Cystine; Elasticity; Rabbits; Sheep; Silk; Skin; Solubility; Synchrotrons; Wool; X-Ray Absorption Spectroscopy; X-Ray Microtomography; X-Rays | 2014 |
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.
Topics: Activating Transcription Factor 4; Apoptosis; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Proliferation; Cell Survival; Citrate (si)-Synthase; Citric Acid Cycle; Glutamine; Humans; Oxaloacetic Acid; RNA Interference; RNA, Small Interfering | 2014 |
Effect of the replacement of aspartic acid/glutamic acid residues with asparagine/glutamine residues in RNase He1 from Hericium erinaceus on inhibition of human leukemia cell line proliferation.
Topics: Amino Acid Sequence; Amino Acid Substitution; Antineoplastic Agents; Asparagine; Aspartic Acid; Basidiomycota; Cell Proliferation; Glutamic Acid; Glutamine; HL-60 Cells; Humans; Hydrogen-Ion Concentration; Leukemia; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Ribonucleases; Structure-Activity Relationship | 2015 |
Mutations in the essential arabinosyltransferase EmbC lead to alterations in Mycobacterium tuberculosis lipoarabinomannan.
Topics: Amino Acid Sequence; Antitubercular Agents; Asparagine; Aspartic Acid; Bacterial Proteins; Blotting, Western; Ethambutol; Gene Expression Regulation, Bacterial; Genes, Essential; Lipopolysaccharides; Microbial Viability; Molecular Sequence Data; Mutation; Mycobacterium tuberculosis; Pentosyltransferases; Protein Sorting Signals; Protein Structure, Secondary; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid | 2014 |
Dendrimeric template of Plasmodium falciparum histidine rich protein II repeat motifs bearing Asp→Asn mutation exhibits heme binding and β-hematin formation.
Topics: Amino Acid Motifs; Amino Acid Sequence; Antigens, Protozoan; Asparagine; Aspartic Acid; Bicarbonates; Binding Sites; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Dendrimers; Heme; Hemeproteins; Kinetics; Mass Spectrometry; Molecular Sequence Data; Mutation; Plasmodium falciparum; Protein Binding; Protein Stability; Protozoan Proteins; Repetitive Sequences, Amino Acid; Spectrum Analysis; Structure-Activity Relationship; Titrimetry | 2014 |
Formation of brominated disinfection byproducts from natural organic matter isolates and model compounds in a sulfate radical-based oxidation process.
Topics: Asparagine; Aspartic Acid; Bromates; Bromine; Citric Acid; Disinfection; Halogenation; Oxidation-Reduction; Sulfates; Trihalomethanes; Water; Water Purification | 2014 |
Sequential capillary electrophoresis analysis using optically gated sample injection and UV/vis detection.
Topics: Asparagine; Aspartic Acid; Electrophoresis, Capillary; Limit of Detection; Models, Chemical; Reproducibility of Results; Spectrophotometry, Ultraviolet | 2015 |
Role of N-glycosylation in renal betaine transport.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Betaine; Carrier Proteins; Dogs; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glycosylation; HEK293 Cells; Humans; Kidney; Madin Darby Canine Kidney Cells; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Osmotic Pressure; Polysaccharides; Protein Transport; Sequence Homology, Amino Acid; Xenopus laevis | 2015 |
Role of host cell-derived amino acids in nutrition of intracellular Salmonella enterica.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Bacterial Proteins; Gene Expression Regulation, Bacterial; Glutamine; Glycoproteins; HeLa Cells; Host-Pathogen Interactions; Humans; Mice; Proline; Salmonella enterica; Succinate Dehydrogenase; Succinic Acid; Vacuoles | 2015 |
High Efficacy of Finafloxacin on Helicobacter pylori Isolates at pH 5.0 Compared with That of Other Fluoroquinolones.
Topics: Amino Acid Substitution; Anti-Bacterial Agents; Asparagine; Aspartic Acid; DNA Gyrase; Female; Fluoroquinolones; Gene Expression; Helicobacter Infections; Helicobacter pylori; Humans; Hydrogen-Ion Concentration; Levofloxacin; Male; Microbial Sensitivity Tests; Middle Aged; Moxifloxacin; Point Mutation; Treatment Outcome | 2015 |
Stable isotope studies reveal pathways for the incorporation of non-essential amino acids in Acyrthosiphon pisum (pea aphids).
Topics: Amino Acids; Animals; Aphids; Asparagine; Aspartic Acid; Buchnera; Carbon Isotopes; Glutamic Acid; Glutamine; Nitrogen; Nitrogen Isotopes; Symbiosis | 2015 |
"Reagent-free" L-asparaginase activity assay based on CD spectroscopy and conductometry.
Topics: Asparaginase; Asparagine; Aspartic Acid; Catalysis; Chitosan; Circular Dichroism; Conductometry; Polyethylene Glycols; Reproducibility of Results | 2016 |
Experimental Data in Support of a Direct Displacement Mechanism for Type I/II L-Asparaginases.
Topics: Amino Acid Sequence; Ammonia; Animals; Asparaginase; Asparagine; Aspartic Acid; Catalytic Domain; Guinea Pigs; Molecular Sequence Data; Mutation, Missense; Protein Binding | 2016 |
Mildly acidic conditions eliminate deamidation artifact during proteolysis: digestion with endoprotease Glu-C at pH 4.5.
Topics: Adrenocorticotropic Hormone; Amides; Amino Acid Sequence; Animals; Artifacts; Asparagine; Aspartic Acid; Buffers; Calmodulin; Cattle; Exenatide; Hydrogen-Ion Concentration; Isoaspartic Acid; Peptides; Protein Processing, Post-Translational; Proteolysis; Serine Endopeptidases; Solutions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Venoms | 2016 |
Independent highly sensitive characterization of asparagine deamidation and aspartic acid isomerization by sheathless CZE-ESI-MS/MS.
Topics: Amides; Asparagine; Aspartic Acid; Electrophoresis, Capillary; Isomerism; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2016 |
Nitrile-synthesizing enzyme: Gene cloning, overexpression and application for the production of useful compounds.
Topics: Alanine; Amino Acids; Aminohydrolases; Asparagine; Aspartic Acid; Cloning, Molecular; Escherichia coli; Gene Expression; Hydro-Lyases; Lyases; Nitriles; Positron-Emission Tomography; Potassium Cyanide; Pseudomonas; Rhodococcus; Substrate Specificity | 2016 |
Synthesis of 6-phosphofructose aspartic acid and some related Amadori compounds.
Topics: Asparagine; Aspartic Acid; Fructosephosphates; Molecular Structure | 2016 |
A Fluorescence-Based High-Throughput Coupled Enzymatic Assay for Quantitation of Isoaspartate in Proteins and Peptides.
Topics: Asparagine; Aspartic Acid; Enzyme Assays; Fluorescence; Isoaspartic Acid; Isomerism; Peptides; Proteins | 2017 |
Using Surface Scans for the Evaluation of Halogen Bonds toward the Side Chains of Aspartate, Asparagine, Glutamate, and Glutamine.
Topics: Amides; Amino Acids; Asparagine; Aspartic Acid; Carboxylic Acids; Crystallography, X-Ray; Drug Design; Glutamic Acid; Glutamine; Halogens; Models, Molecular; Molecular Conformation; Solvents | 2016 |
Quantification of in vivo site-specific Asp isomerization and Asn deamidation of mAbs in animal serum using IP-LC-MS.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Asparagine; Aspartic Acid; Chromatography, Liquid; Humans; Immunoprecipitation; Isomerism; Macaca fascicularis; Male; Tandem Mass Spectrometry | 2016 |
Conformational Change in the Active Site of Streptococcal Unsaturated Glucuronyl Hydrolase Through Site-Directed Mutagenesis at Asp-115.
Topics: Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Bacterial Proteins; Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Escherichia coli; Gene Expression; Glycosaminoglycans; Glycoside Hydrolases; Hydrogen Bonding; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Recombinant Proteins; Sequence Alignment; Streptococcus agalactiae; Structure-Activity Relationship; Substrate Specificity | 2016 |
A metabolic intermediate of the fructose-asparagine utilization pathway inhibits growth of a Salmonella fraB mutant.
Topics: Animals; Asparagine; Aspartic Acid; Bacterial Proteins; Fructose; Fructosephosphates; Gene Expression Regulation, Bacterial; Mass Spectrometry; Metabolomics; Mice; Mutation; Phosphotransferases; Salmonella enterica | 2016 |
Isolation of Coralmycins A and B, Potent Anti-Gram Negative Compounds from the Myxobacteria Corallococcus coralloides M23.
Topics: Anti-Bacterial Agents; Asparagine; Aspartic Acid; Depsipeptides; Escherichia coli; Hep G2 Cells; Humans; Klebsiella pneumoniae; Microbial Sensitivity Tests; Molecular Structure; Myxococcales; Nitro Compounds; Nuclear Magnetic Resonance, Biomolecular; Pseudomonas aeruginosa; Structure-Activity Relationship | 2016 |
A Rare UGT2B7 Variant Creates a Novel N-Glycosylation Site at Codon 121 with Impaired Enzyme Activity.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Cell Line; Codon; Genetic Variation; Glucuronides; Glucuronosyltransferase; Glycosylation; HEK293 Cells; Humans; Mycophenolic Acid; Polymorphism, Single Nucleotide; Protein Processing, Post-Translational | 2016 |
Neandertals made jewelry, proteins confirm.
Topics: Animals; Asparagine; Aspartic Acid; Bone and Bones; Collagen; Creativity; Fossils; France; Humans; Jewelry; Neanderthals; Radiometric Dating | 2016 |
Extensive deamidation of RNase A inhibits its oligomerization through 3D domain swapping.
Topics: Amides; Amyloid; Animals; Asparagine; Aspartic Acid; Cattle; Enzyme Stability; Glutamine; Mutation; Nuclear Magnetic Resonance, Biomolecular; Protein Domains; Protein Multimerization; Ribonuclease, Pancreatic | 2017 |
Characterization of a Salmonella sugar kinase essential for the utilization of fructose-asparagine.
Topics: Asparagine; Aspartic Acid; Bacterial Proteins; Escherichia coli; Fructose; Gene Expression Regulation, Bacterial; Hydrogen-Ion Concentration; Kinetics; Operon; Phosphotransferases; Recombinant Proteins; Repressor Proteins; Salmonella enterica; Stereoisomerism; Substrate Specificity; Temperature | 2017 |
Exploiting charge differences for the analysis of challenging post-translational modifications by capillary electrophoresis-mass spectrometry.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Citrulline; Electrophoresis, Capillary; Female; Histones; Humans; Isoaspartic Acid; Phosphopeptides; Placenta; Pregnancy; Protein Processing, Post-Translational; Tandem Mass Spectrometry | 2017 |
Biocontrol of Monilinia laxa by Aureobasidium pullulans strains: Insights on competition for nutrients and space.
Topics: Antibiosis; Ascomycota; Asparagine; Aspartic Acid; Fruit; Fruit and Vegetable Juices; Germination; Glucans; Mycelium; Plant Diseases; Prunus persica; Saccharomycetales; Spores, Fungal | 2017 |
A High-Throughput Bioluminescent Assay to Monitor the Deamidation of Asparagine and Isomerization of Aspartate Residues in Therapeutic Proteins and Antibodies.
Topics: Amides; Animals; Antineoplastic Agents, Immunological; Asparagine; Aspartic Acid; Bevacizumab; Calmodulin; Cattle; High-Throughput Screening Assays; Humans; Isomerism; Luminescent Measurements; Myoglobin; Proteins | 2017 |
An Asp to Asn mutation is a toxic trigger in beta-2 microglobulin: structure and biophysics.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; beta 2-Microglobulin; Biophysics; Humans; Mutation, Missense; Protein Folding | 2017 |
Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial.
Topics: Aged; Asparagine; Aspartic Acid; Biomarkers; Carnitine; Female; Heart Failure; Humans; Male; Metabolomics; Middle Aged; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Stroke Volume | 2017 |
A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus.
Topics: Asparagine; Aspartate Aminotransferases; Aspartic Acid; Cell Proliferation; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Herpesvirus 8, Human; Humans; Metabolic Networks and Pathways; Neoplasms; Nitrogen; Nucleotides | 2017 |
Non-syndromic cardiac progeria in a patient with the rare pathogenic p.Asp300Asn variant in the LMNA gene.
Topics: Adult; Amino Acid Sequence; Asparagine; Aspartic Acid; Base Sequence; Coronary Artery Disease; Echocardiography; Electrocardiography; Fatal Outcome; Female; Humans; Lamin Type A; Mutation, Missense; Myocardial Infarction; Pedigree; Progeria; Sequence Homology, Amino Acid | 2017 |
Stereoselective Deuteration in Aspartate, Asparagine, Lysine, and Methionine Amino Acid Residues Using Fumarate as a Carbon Source for Escherichia coli in D
Topics: Amino Acids; Asparagine; Aspartic Acid; Carbon; Culture Media; Deuterium; Escherichia coli; Fumarates; Humans; Lysine; Methionine; Models, Molecular; Mutant Proteins; NIMA-Interacting Peptidylprolyl Isomerase; Stereoisomerism | 2017 |
Molecular characterization and regulation of operons for asparagine and aspartate uptake and utilization in Pseudomonas aeruginosa.
Topics: Asparagine; Aspartic Acid; Bacterial Proteins; Biological Transport; Dicarboxylic Acids; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genes, Regulator; Membrane Transport Proteins; Oligonucleotide Array Sequence Analysis; Operon; Promoter Regions, Genetic; Protein Binding; Pseudomonas aeruginosa; Regulatory Sequences, Nucleic Acid | 2018 |
Photocycle of Sensory Rhodopsin II from Halobacterium salinarum (HsSRII): Mutation of D103 Accelerates M Decay and Changes the Decay Pathway of a 13-cis O-like Species.
Topics: Amino Acid Substitution; Asparagine; Aspartic Acid; Cold Temperature; Glutamic Acid; Halobacterium salinarum; Halorhodopsins; Hydrogen Bonding; Light; Mutation; Photochemical Processes; Photolysis; Sensory Rhodopsins; Spectroscopy, Fourier Transform Infrared | 2018 |
Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.
Topics: Alanine; Amino Acid Substitution; Asparagine; Aspartic Acid; Bacterial Proteins; Catalytic Domain; Crystallography, X-Ray; Flap Endonucleases; Manganese; Models, Molecular; Mutation; Mycobacterium smegmatis; Phosphodiesterase I | 2018 |
Effects of nitrogen combined with zinc application on glutamate, glutamine, aspartate and asparagine accumulation in two winter wheat cultivars.
Topics: Asparagine; Aspartic Acid; Glutamic Acid; Glutamine; Nitrogen; Triticum; Zinc | 2018 |
Asparagine Deamidation in a Complementarity Determining Region of a Recombinant Monoclonal Antibody in Complex with Antigen.
Topics: Amides; Antibodies, Monoclonal; Antigens; Asparagine; Aspartic Acid; Molecular Structure; Recombinant Proteins | 2018 |
Aspartate deficiency limits peptidoglycan synthesis and sensitizes cells to antibiotics targeting cell wall synthesis in Bacillus subtilis.
Topics: Anti-Bacterial Agents; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Bacillus subtilis; Cell Wall; Diaminopimelic Acid; Glutamic Acid; Peptidoglycan | 2018 |
Metabolic profiles of cysteine, methionine, glutamate, glutamine, arginine, aspartate, asparagine, alanine and glutathione in Streptococcus thermophilus during pH-controlled batch fermentations.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Culture Media; Cysteine; Fermentation; Glutamic Acid; Glutamine; Glutathione; Hydrogen-Ion Concentration; Metabolic Networks and Pathways; Metabolome; Methionine; Nitrogen; Streptococcus thermophilus | 2018 |
A critical analysis of L-asparaginase activity quantification methods-colorimetric methods versus high-performance liquid chromatography.
Topics: Asparaginase; Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Colorimetry; Enzyme Assays; Humans | 2018 |
Spontaneous cross-linking of proteins at aspartate and asparagine residues is mediated via a succinimide intermediate.
Topics: Aged; Amino Acid Sequence; Asparagine; Aspartic Acid; Humans; Lens, Crystalline; Succinimides | 2018 |
Crystal structures of green fluorescent protein with the unnatural amino acid 4-nitro-L-phenylalanine.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Asparagine; Aspartic Acid; Binding Sites; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Gene Expression; Genes, Reporter; Genetic Vectors; Green Fluorescent Proteins; Models, Molecular; Mutagenesis, Site-Directed; Nitriles; Phenylalanine; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Engineering; Protein Interaction Domains and Motifs; Recombinant Proteins; Structural Homology, Protein | 2018 |
Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells.
Topics: Asparagine; Aspartic Acid; Blood Banks; Blood Preservation; Erythrocytes; Humans; Methylation; Oxidative Stress; Protein Processing, Post-Translational; Proteomics; Time Factors | 2018 |
Production and structural modeling of a novel asparaginase in Yarrowia lipolytica.
Topics: Amino Acid Sequence; Ammonia; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Bioreactors; Culture Media; Factor Analysis, Statistical; Fermentation; Fungal Proteins; Industrial Microbiology; Models, Molecular; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Yarrowia | 2019 |
Genotoxic activity of L-asparaginase produced by Streptomyces ansochromogenes UFPEDA 3420.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Cell Line, Tumor; DNA Damage; Enzyme Assays; Humans; Inhibitory Concentration 50; Leukocytes, Mononuclear; Micronucleus Tests; Streptomyces | 2019 |
Influence of functional variants Asp312Asn and Lys751Gln of Xeroderma Pigmentosum Group D (XPD) and Glutathione S-transferase Mu 1 (GSTM1) and Theta 1 (GSTT1) genes on cutaneous melanoma susceptibility and prognosis.
Topics: Aged; Asparagine; Aspartic Acid; Cell Survival; Disease-Free Survival; Genetic Predisposition to Disease; Genetic Variation; Genotype; Glutamine; Glutathione Transferase; Humans; Lysine; Melanoma; Middle Aged; Prognosis; Proportional Hazards Models; Skin Neoplasms; Treatment Outcome; Xeroderma Pigmentosum | 2019 |
Interaction of aspartic acid and asparagine with RNA nucleobases: a quantum chemical view.
Topics: Adenosine; Asparagine; Aspartic Acid; Binding Sites; Cytidine; Guanidine; Hydrogen Bonding; Models, Molecular; Nucleic Acid Conformation; Quantum Theory; RNA; Thermodynamics; Uridine | 2020 |
Amino acid signature predictive of incident prediabetes: A case-control study nested within the longitudinal pathobiology of prediabetes in a biracial cohort.
Topics: Adult; Amino Acids; Asparagine; Aspartic Acid; Black or African American; Blood Glucose; Case-Control Studies; Cohort Studies; Female; Follow-Up Studies; Histidine; Humans; Insulin Resistance; Insulin-Secreting Cells; Longitudinal Studies; Male; Middle Aged; Prediabetic State; Predictive Value of Tests; Racial Groups; White People | 2019 |
The cytosolic form of aspartate aminotransferase is required for full activation of TOR complex 1 in fission yeast.
Topics: Arginine; Asparagine; Aspartate Aminotransferases; Aspartic Acid; Cytosol; Gene Expression Regulation, Fungal; Isoenzymes; Mechanistic Target of Rapamycin Complex 1; Methionine Sulfoximine; Mutation; Nitrogen; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Sirolimus | 2019 |
Site-specific rapid deamidation and isomerization in human lens αA-crystallin in vitro.
Topics: Asparagine; Aspartic Acid; Humans; Lens, Crystalline; Molecular Conformation; Mutagenesis, Site-Directed; Stereoisomerism | 2020 |
Off-pathway 3D-structure provides protection against spontaneous Asn/Asp isomerization: shielding proteins Achilles heel.
Topics: Asparagine; Aspartic Acid; Glycine; Humans; Hydrogen-Ion Concentration; Hydrolysis; Isoelectric Point; Isomerism; Kinetics; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Mutation; Ornithine Decarboxylase; Peptides; Protein Structure, Secondary; Proteome; Temperature | 2020 |
p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; HCT116 Cells; HEK293 Cells; Homeostasis; Humans; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Protein Serine-Threonine Kinases; RNA Interference; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2020 |
Metabolomics approach revealed robust changes in amino acid and biogenic amine signatures in patients with schizophrenia in the early course of the disease.
Topics: Adult; Amino Acids; Antipsychotic Agents; Asparagine; Aspartic Acid; Biogenic Amines; Chromatography, Liquid; Early Diagnosis; Female; Glutamic Acid; Glutamine; Humans; Male; Metabolome; Metabolomics; Proline; Schizophrenia; Tandem Mass Spectrometry; Taurine; Young Adult | 2020 |
Interactive effects of asparagine and aspartate homeostasis with sex and age for the risk of type 2 diabetes risk.
Topics: Adolescent; Adult; Aging; Asian People; Asparagine; Aspartic Acid; China; Diabetes Mellitus, Type 2; Female; Homeostasis; Humans; Male; Middle Aged; Retrospective Studies; Risk Factors; Sex Factors; Young Adult | 2020 |
Detecting aspartate isomerization and backbone cleavage after aspartate in intact proteins by NMR spectroscopy.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Isomerism; Magnetic Resonance Spectroscopy; Nuclear Magnetic Resonance, Biomolecular; Peptides; Proteins; Structure-Activity Relationship | 2021 |
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.
Topics: Activating Transcription Factor 4; Animals; Asparagine; Aspartic Acid; Cell Line, Tumor; Cell Proliferation; Diet; Electron Transport Chain Complex Proteins; Humans; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred NOD; Mitochondria; Neoplasms; Nucleotides; Survival Rate | 2021 |
Gut bacterial gene changes following pegaspargase treatment in pediatric patients with acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Child; Genes, Bacterial; Glutamic Acid; Glutamine; Humans; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
Discovery of serum biomarkers for diagnosis of tuberculosis by NMR metabolomics including cross-validation with a second cohort.
Topics: Asparagine; Aspartic Acid; Biomarkers; Glutamates; Humans; Hypoxanthines; Inosine; Magnetic Resonance Spectroscopy; Mannose; Metabolomics; Tuberculosis | 2022 |
Topics: Alleles; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Cattle; Color Vision Defects; Cyclic Nucleotide-Gated Cation Channels; Electroretinography; Female; Gene Expression; Gene Frequency; Homozygote; Male; Mutation, Missense; Phenotype; Protein Subunits; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells; Whole Genome Sequencing | 2021 |
Conformational preferences of Ac-Pro-azaXaa-NHMe (Xaa = Asn, Asp, Ala) and the effect of intramolecular hydrogen bonds on their stability in gas phase and solution.
Topics: Alanine; Asparagine; Aspartic Acid; Gases; Hydrogen Bonding; Models, Molecular; Proline; Protein Conformation; Protein Stability; Solutions | 2021 |
Mechanism of high D-aspartate production in the lactic acid bacterium Latilactobacillus sp. strain WDN19.
Topics: Asparagine; Aspartic Acid; D-Aspartic Acid; Humans; Lactic Acid; Lactobacillales; Lactobacillus | 2022 |
Topics: Asparaginase; Asparagine; Aspartic Acid; Flour; Saccharomyces cerevisiae; Triticum | 2022 |
Combined proteomic and biochemical analyses redefine the consensus sequence requirement for epidermal growth factor-like domain hydroxylation.
Topics: Antigens, Ly; Asparagine; Aspartic Acid; Consensus Sequence; Epidermal Growth Factor; Humans; Hydroxylation; Proteomics | 2022 |
NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Cytokines; Disease Models, Animal; Glucose; Histidine; Imiquimod; Interleukin-17; Interleukin-23; Interleukin-8; Magnetic Resonance Spectroscopy; Mice; Moxibustion; Psoriasis; Skin; Taurine; Triglycerides; Valine | 2023 |
Rapid, sensitive analysis method for determining the nitrogen stable isotope ratio of total free amino acids in soil.
Topics: Alanine; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cysteine; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Histidine; Leucine; Lysine; Nitrogen; Nitrogen Isotopes; Phenylalanine; Serine; Soil; Tryptophan | 2022 |
Recent strains of influenza D virus create a new genetic cluster for European strains.
Topics: Alanine; Animals; Arginine; Asparagine; Aspartic Acid; Cattle; Cattle Diseases; Glycine; Nucleotides; Orthomyxoviridae; Orthomyxoviridae Infections; Phylogeny; Proline; Serine; Thogotovirus; Threonine; Valine | 2022 |
Massive annotation of bacterial L-asparaginases reveals their puzzling distribution and frequent gene transfer events.
Topics: Ammonia; Asparaginase; Asparagine; Aspartic Acid; Bacteria; Bacterial Proteins; Gene Transfer, Horizontal; Phylogeny | 2022 |
Effects of multi-walled carbon nanotubes in soil on earthworm growth and reproduction, enzymatic activities, and metabolomics.
Topics: Animals; Asparagine; Aspartic Acid; Galactose; Glutamine; Glutathione Transferase; Nanotubes, Carbon; Oligochaeta; Oxidative Stress; Pyruvates; Reproduction; Soil; Soil Pollutants; Superoxide Dismutase | 2022 |
Targeting Asparagine Synthetase in Tumorgenicity Using Patient-Derived Tumor-Initiating Cells.
Topics: Animals; Asparaginase; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Glutamine; Humans; Lung Neoplasms; Mice; Mice, Nude; Proto-Oncogene Proteins p21(ras); RNA, Small Interfering; Spheroids, Cellular; Xenograft Model Antitumor Assays | 2022 |
Analysis of Heat Shock Proteins Based on Amino Acids for the Tomato Genome.
Topics: Amino Acids; Asparagine; Aspartic Acid; Codon; Heat-Shock Proteins; Phenylalanine; Plant Breeding; Solanum lycopersicum | 2022 |
Wild soybean salt tolerance metabolic model: Assessment of storage protein mobilization in cotyledons and C/N balance in the hypocotyl/root axis.
Topics: Asparagine; Aspartic Acid; Carbon; Cotyledon; Fabaceae; Gene Expression Regulation, Plant; Glutamic Acid; Glycine max; Hypocotyl; Nitrogen; Plant Proteins; Salt Tolerance | 2023 |
Metabolic factors associated with incident fracture among older adults with type 2 diabetes mellitus: a nested case-control study.
Topics: Aged; Amino Acids; Asparagine; Aspartic Acid; Case-Control Studies; Diabetes Mellitus, Type 2; Fatty Acids; Fractures, Bone; Glutamine; Humans; Middle Aged; Risk Factors | 2023 |
Metabolomic Profiling of Asparagine Deprivation in Asparagine Synthetase Deficiency Patient-Derived Cells.
Topics: Amino Acid Metabolism, Inborn Errors; Asparagine; Aspartate-Ammonia Ligase; Aspartic Acid; Atrophy; Humans; Intellectual Disability; Microcephaly | 2023 |
Asparagine Uptake: a Cellular Strategy of
Topics: Amino Acids; Asparagine; Aspartic Acid; Carbon; Methane; Methylocystaceae; Proteome; Pyruvates; Salt Stress; Sodium Chloride | 2023 |
Discrimination of blood metabolomics profiles in neonates with idiopathic polyhydramnios.
Topics: Alanine; Asparagine; Aspartic Acid; Cesarean Section; Child; Chromatography, Liquid; Female; Glutamates; Homocysteine; Humans; Infant, Newborn; Phenylalanine; Polyhydramnios; Pregnancy; RNA, Transfer; Serine; Tandem Mass Spectrometry | 2023 |
Oral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus.
Topics: Animals; Asparagine; Aspartic Acid; B-Lymphocytes, Regulatory; Diabetes Mellitus, Type 2; Diabetes, Gestational; Dysbiosis; Female; Humans; Inflammation; Leptin; Mice; Pregnancy; T-Lymphocytes, Regulatory | 2023 |
Radiocarbon Flux Measurements Reveal Mechanistic Insight into Heat-Stress Induction of Nicotine Biosynthesis in
Topics: Asparagine; Aspartic Acid; Carbon; Carbon Dioxide; Hot Temperature; Nicotiana; Nicotine; Photosynthesis; Plant Leaves; Ribulose-Bisphosphate Carboxylase | 2023 |