aspartic acid has been researched along with amyloid beta-peptides in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 9 (40.91) | 29.6817 |
| 2010's | 9 (40.91) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Daggett, V; Kirshenbaum, K | 1 |
| Lee, JP; Zhang, S | 1 |
| Coppel, Y; Damian, L; Faller, P; Guilloreau, L; Mazarguil, H; Winterhalter, M | 1 |
| Asano, S; Endo, N; Furiya, Y; Ishii, K; Mori, H; Sahara, N; Shirasawa, T; Takio, K; Tomiyama, T | 1 |
| Duffy, LK; Vyas, SB | 1 |
| Kaneko, I; Kubo, T; Morimoto, K | 1 |
| Ihara, Y; Mitsumori, R; Morishima-Kawashima, M; Qi, Y; Sato, T | 1 |
| Beher, D; Clarke, EE; De Strooper, B; Hunt, P; Nadin, A; Nunn, EJ; Nyabi, O; Shearman, MS; Wrigley, JD | 1 |
| Komano, H; Kurono, Y; Maeda, Y; Nishimura, M; Sai, X; Shiraishi, H; Wang, HQ; Yanagisawa, K | 1 |
| Griffiths, WJ; Hosia, W; Johansson, J | 1 |
| Abrahamson, EE; Ciallella, JR; Clark, RS; DeKosky, ST; Flood, DG; Hope, CE; Ikonomovic, MD; Isanski, BA; Paljug, WR | 1 |
| Meredith, SC; Orgel, JP; Sciarretta, KL; Tycko, R | 1 |
| Chang, WH; Chang, YJ; Chen, WT; Chen, YR; Cheng, CY; Cheng, IH; Hong, CJ; Hsieh, YF; Huang, HT; Liao, JY; Lin, YT; Liu, HC | 1 |
| Derreumaux, P; Li, MS; Ngo, ST; Nguyen, PH; Viet, MH | 1 |
| Govoni, S; Grilli, M; Marchi, M; Mura, E; Olivero, G; Preda, S; Salamone, A; Zappettini, S | 1 |
| Chamberlain, R; Curran, GL; Garwood, M; Jack, CR; Kobayashi, D; Lin, JC; Marjańska, M; Poduslo, JF; Preboske, G; Weigand, SD; Wengenack, TM | 1 |
| Chiaraluce, R; Consalvi, V; Giordano, C; Minicozzi, V; Morante, S; Narcisi, C; Punzi, P; Rossi, GC | 1 |
| Arai, H; Fujii, C; Hata, S; Higuchi, S; Igarashi, K; Ishii, R; Iwai, N; Moriya, M; Ohrui, T; Suzuki, T; Tokuda, T; Uemura, K; Waragai, M; Yoshida, M | 1 |
| Doert, A; Eckert, GP; Müller, WE; Pilatus, U; Zanella, F | 1 |
| Cho, AE; Jang, SS; Kwon, I; Lee, J | 1 |
| Bie, B; Foss, JF; Naguib, M; Wu, J | 1 |
| Cheglakov, IB; Kozin, SA; Kukharsky, MS; Kulikova, AA; Makarov, AA; Ovchinnikov, RK | 1 |
1 trial(s) available for aspartic acid and amyloid beta-peptides
| Article | Year |
|---|---|
Effect of the Tottori familial disease mutation (D7N) on the monomers and dimers of Aβ40 and Aβ42.
Topics: Alzheimer Disease; Amination; Amyloid beta-Peptides; Asparagine; Aspartic Acid; Humans; Hydrogen-Ion Concentration; Lysine; Molecular Dynamics Simulation; Multiprotein Complexes; Mutation; Peptide Fragments; Protein Multimerization; Protein Structure, Secondary; Static Electricity; Substrate Specificity; Up-Regulation | 2013 |
21 other study(ies) available for aspartic acid and amyloid beta-peptides
| Article | Year |
|---|---|
Sequence effects on the conformational properties of the amyloid beta (1-28) peptide: testing a proposed mechanism for the alpha-->beta transition.
Topics: Alanine; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Glutamates; Glutamine; Glycine; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Molecular Sequence Data; Peptide Fragments; Protein Structure, Secondary; Structure-Activity Relationship; Water | 1995 |
Selectively 2H-labeled Glu/Asp: application to pKa measurements in Abeta amyloid peptides.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Deuterium; Glutamic Acid; Histidine; Isotope Labeling; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptide Fragments; Protein Conformation | 2000 |
Structural and thermodynamical properties of CuII amyloid-beta16/28 complexes associated with Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Binding Sites; Copper; Humans; Peptide Fragments; Protein Binding; Spectrum Analysis; Thermodynamics; Tyrosine | 2006 |
Racemization: its biological significance on neuropathogenesis of Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Biopolymers; Brain; Humans; Isomerism; Microscopy, Electron; Molecular Sequence Data; Nerve Degeneration; Nerve Tissue Proteins; Peptide Fragments; Protein Binding; Solubility; Spectrometry, Fluorescence; Stereoisomerism | 1994 |
Stabilization of secondary structure of Alzheimer beta-protein by aluminum(III) ions and D-Asp substitutions.
Topics: Amyloid beta-Peptides; Aspartic Acid; Circular Dichroism; Copper; Peptide Fragments; Protein Structure, Secondary; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1995 |
Drastic neuronal loss in vivo by beta-amyloid racemized at Ser(26) residue: conversion of non-toxic [D-Ser(26)]beta-amyloid 1-40 to toxic and proteinase-resistant fragments.
Topics: Alzheimer Disease; Amino Acid Isomerases; Amino Acid Sequence; Aminopeptidases; Amyloid beta-Peptides; Animals; Aspartic Acid; Chymotrypsin; Coloring Agents; Endopeptidases; Excitatory Amino Acid Agonists; Hippocampus; Ibotenic Acid; Male; Nerve Degeneration; Neurofibrillary Tangles; Neurons; PC12 Cells; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Serine | 2001 |
Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.
Topics: Amino Acid Substitution; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Asparagine; Aspartic Acid; Aspartic Acid Endopeptidases; Carbamates; Cell Line; Cell-Free System; CHO Cells; Cricetinae; Culture Media; Dipeptides; Endopeptidases; Humans; Intracellular Fluid; Isoleucine; Membrane Proteins; Methionine; Mutagenesis, Site-Directed; Peptide Fragments; Presenilin-1; Presenilin-2; Serine Proteinase Inhibitors; Threonine; Transfection; Up-Regulation; Valine | 2003 |
Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid; Aspartic Acid Endopeptidases; Binding Sites; Blotting, Western; Cell Line; Cell Membrane; Cell-Free System; Cholic Acids; Chromosomal Proteins, Non-Histone; Conserved Sequence; Culture Media, Conditioned; Detergents; Embryo, Mammalian; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Humans; Kidney; Mutagenesis, Site-Directed; Peptide Fragments; Protein Binding; Protein Folding; Protein Structure, Tertiary; Substrate Specificity; Transfection; Tyrosine | 2004 |
PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid; Aspartic Acid Endopeptidases; Blotting, Western; Carbamates; Cell Line; Dipeptides; Dose-Response Relationship, Drug; Endopeptidases; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; gamma-Aminobutyric Acid; Gene Expression Regulation; Membrane Glycoproteins; Membrane Proteins; Mice; Peptide Fragments; Presenilin-1; Presenilin-2; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-myc; Radioimmunoassay; Statistics, Nonparametric; Transgenes; Triglycerides | 2004 |
Hydrolysis of the amyloid beta-peptide (A beta) 1-40 between Asp23-Val24 produces non-aggregating fragments. An electrospray mass spectrometric study.
Topics: Amyloid beta-Peptides; Aspartic Acid; Hydrolysis; Peptide Fragments; Spectrometry, Mass, Electrospray Ionization; Time Factors; Valine | 2005 |
Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Blotting, Western; Brain Injuries; Caspase 3; Caspase Inhibitors; Caspases; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Functional Laterality; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Mice, Transgenic; Neural Inhibition; Peptide Fragments; Stilbamidines; Time Factors | 2006 |
Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils.
Topics: Amyloid; Amyloid beta-Peptides; Amyloid Neuropathies, Familial; Aspartic Acid; Benzothiazoles; Glutamic Acid; Humans; Kinetics; Leucine; Lysine; Microscopy, Electron, Transmission; Models, Molecular; Mutation, Missense; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Phenylalanine; Protein Structure, Secondary; Spectrometry, Fluorescence; Thiazoles; X-Ray Diffraction | 2009 |
Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aspartic Acid; Base Sequence; Cells, Cultured; Copper; Female; HEK293 Cells; Histidine; Humans; Middle Aged; Molecular Sequence Data; Mutation; Peptide Fragments; Polymerization; Taiwan; Zinc | 2012 |
Inhibitory effects of beta-amyloid on the nicotinic receptors which stimulate glutamate release in rat hippocampus: the glial contribution.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Aspartic Acid; Azetidines; Bridged Bicyclo Compounds, Heterocyclic; Choline; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peptide Fragments; Pyridines; Quinuclidines; Rats; Rats, Wistar; Receptors, Nicotinic | 2014 |
Treatment effects in a transgenic mouse model of Alzheimer's disease: a magnetic resonance spectroscopy study after passive immunization.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain; Choline; Disease Models, Animal; Humans; Immunization, Passive; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Peptide Fragments; Presenilin-1; Statistics, Nonparametric | 2014 |
Computational and experimental studies on β-sheet breakers targeting Aβ1-40 fibrils.
Topics: Amyloid beta-Peptides; Asparagine; Aspartic Acid; Circular Dichroism; Humans; Molecular Dynamics Simulation; Peptide Fragments; Protein Folding; Protein Stability; Protein Structure, Secondary; Taurine | 2014 |
Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aspartic Acid; Brain; Choline; Dementia; Disease Progression; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Retrospective Studies; Tritium | 2014 |
¹H- and ¹³C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain; Carbon-13 Magnetic Resonance Spectroscopy; Creatine; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Humans; Inositol; Male; Mice, Transgenic; Mutation; Peptide Fragments; Phosphorylcholine; Proton Magnetic Resonance Spectroscopy | 2015 |
Investigation of the effect of erythrosine B on amyloid beta peptide using molecular modeling.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Aspartic Acid; Binding Sites; Erythrosine; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Lysine; Molecular Dynamics Simulation; Peptide Fragments; Protein Binding; Protein Domains; Protein Structure, Secondary; Static Electricity; Thermodynamics; Water | 2016 |
Amyloid Fibril-Induced Astrocytic Glutamate Transporter Disruption Contributes to Complement C1q-Mediated Microglial Pruning of Glutamatergic Synapses.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartic Acid; Astrocytes; CA1 Region, Hippocampal; Ceftriaxone; Cognition Disorders; Complement C1q; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamic Acid; Male; Microglia; Morris Water Maze Test; Neurons; Patch-Clamp Techniques; Peptide Fragments; Phagocytosis; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses; Up-Regulation | 2020 |
Intracerebral Injection of Metal-Binding Domain of Aβ Comprising the Isomerized Asp7 Increases the Amyloid Burden in Transgenic Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Analysis of Variance; Animals; Aspartic Acid; Disease Models, Animal; Gene Expression Regulation; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Peptide Fragments; Plaque, Amyloid; Presenilin-1 | 2016 |