aspartic acid has been researched along with 1-hydroxy-3-amino-2-pyrrolidone in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (61.11) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Evans, RH; Francis, AA; Watkins, JC | 1 |
| Britt, M; Chapdelaine, MJ; Keith, RA; LaMonte, D; Mangano, TJ; Patel, J; Powel, RJ; Pullan, LM; Stumpo, RJ; Warwick, PJ | 1 |
| Keith, R; Patel, J; Salama, A; Thompson, C; Zinkand, WC | 1 |
| Donald, AE; Foster, AC; Hutson, PH; Iversen, LL; Iversen, SD; Kemp, JA; Leeson, PD; Marshall, GR; Oles, RJ; Singh, L | 1 |
| Colpaert, FC; Koek, W | 1 |
| Cler, J; Emmett, MR; Iyengar, S; Mick, S; Oei, E; Rao, TS; Wood, PL | 1 |
| Harris, KM; Miller, RJ; Reynolds, IJ | 1 |
| Cler, J; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Wood, PL | 1 |
| Drejer, J; Honoré, T; Jensen, LH; Sheardown, MJ; Stidsen, CE | 1 |
| Keith, RA; Klika, AB; Mangano, TJ; Meiners, BA; Patel, J; Salama, AI; Stumpo, RJ | 1 |
| Drejer, J; Honoré, T; Nielsen, EO; Sheardown, M | 1 |
| Johnston, MV; McDonald, JW; Silverstein, FS; Uckele, J | 1 |
| Crawford, M; Roberts, PJ | 1 |
| Fletcher, EJ; Lodge, D | 1 |
| Stone, TW | 1 |
| Perkins, MN; Stone, TW | 1 |
| Mikuni, M; Saitoh, K; Shinno, H; Takahashi, K; Tomita, U; Yamawaki, S | 1 |
18 other study(ies) available for aspartic acid and 1-hydroxy-3-amino-2-pyrrolidone
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Mg2+-like selective antagonism of excitatory amino acid-induced responses by alpha, epsilon-diaminopimelic acid, D-alpha-aminoadipate and HA-966 in isolated spinal cord of frog and immature rat.
Topics: 2-Aminoadipic Acid; Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Anura; Aspartic Acid; Diaminopimelic Acid; Evoked Potentials; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Kainic Acid; Magnesium; Motor Neurons; Pimelic Acids; Pyrrolidinones; Rats; Spinal Cord; Synaptic Transmission | 1978 |
Stereoselectivity for the (R)-enantiomer of HA-966 (1-hydroxy-3-aminopyrrolidone-2) at the glycine site of the N-methyl-D-aspartate receptor complex.
Topics: Allosteric Site; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Hippocampus; Ileum; Isometric Contraction; Kinetics; Male; Muscle, Smooth; N-Methylaspartate; Neurons; Norepinephrine; Pyrrolidinones; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes | 1990 |
Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Serine | 1990 |
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.
Topics: 4-Butyrolactone; Acoustic Stimulation; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dopamine; Furans; Glycine; In Vitro Techniques; Isomerism; Kinetics; Male; Membrane Potentials; Mice; Mice, Inbred DBA; Motor Activity; N-Methylaspartate; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Seizures; Serotonin | 1990 |
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glycine; Kainic Acid; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Phencyclidine; Pyrrolidinones; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
In vivo antagonism of agonist actions at N-methyl-D-aspartate and N-methyl-D-aspartate-associated glycine receptors in mouse cerebellum: studies of 1-hydroxy-3-aminopyrrolidone-2.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Male; Mice; N-Methylaspartate; Pyrrolidinones; Receptors, Glycine; Receptors, Neurotransmitter | 1990 |
NMDA receptor antagonists that bind to the strychnine-insensitive glycine site and inhibit NMDA-induced Ca2+ fluxes and [3H]GABA release.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Calcium; Desipramine; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Ketamine; Kynurenine; Membranes; N-Methylaspartate; Piperazines; Pyrrolidinones; Radioligand Assay; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
In vivo modulation of the N-methyl-D-aspartate receptor complex by D-serine: potentiation of ongoing neuronal activity as evidenced by increased cerebellar cyclic GMP.
Topics: Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Cycloserine; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Mice; N-Methylaspartate; Neurons; Piperazines; Pyrrolidinones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1989 |
A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cortical Spreading Depression; Female; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pregnancy; Pyrrolidinones; Quinoxalines; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine | 1989 |
HA-966 acts at a modulatory glycine site to inhibit N-methyl-D-aspartate-evoked neurotransmitter release.
Topics: Animals; Aspartic Acid; Binding Sites; Dibenzocycloheptenes; Dizocilpine Maleate; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurotransmitter Agents; Norepinephrine; Piperazines; Pyrrolidinones; Rats; Strychnine | 1989 |
Glycine reverses the effect of HA-966 on NMDA responses in cultured rat cortical neurons and in chick retina.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Chickens; Cortical Spreading Depression; Glycine; In Vitro Techniques; N-Methylaspartate; Neurons; Pyrrolidinones; Rats; Retina | 1989 |
HA-966 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces N-methyl-D-aspartate (NMDA)-mediated brain damage.
Topics: Animals; Animals, Newborn; Aspartic Acid; Brain Diseases; Corpus Striatum; N-Methylaspartate; Oxadiazoles; Pyrrolidinones; Quisqualic Acid; Rats; Rats, Inbred Strains | 1989 |
1-Hydroxy-3-aminopyrrolid-2-one (HA-966) and kynurenate antagonize N-methyl-D-aspartate induced enhancement of [3H]dopamine release from rat striatal slices.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; Drug Antagonism; Kynurenic Acid; Male; N-Methylaspartate; Potassium; Pyrrolidinones; Rats; Rats, Inbred Strains | 1989 |
Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phosphonovalerate (D-AP5) on rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Evoked Potentials; Glycine; In Vitro Techniques; N-Methylaspartate; Pyrrolidinones; Rats; Valine | 1988 |
Studies with excitatory amino acid antagonists in rat CNS: 2-amino-5-phosphonovaleric acid, phenytoin, and benzodiazepines.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Brain; Cerebral Cortex; Glutamates; Male; Neurons; Phenytoin; Pyramidal Tracts; Pyrrolidinones; Rats | 1981 |
Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system.
Topics: Animals; Aspartic Acid; Central Nervous System; Evoked Potentials; Glutamates; Male; N-Methylaspartate; Oxadiazoles; Pyridines; Pyrrolidinones; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1983 |
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine Maleate; Glioma; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Ion Channels; Kainic Acid; Kinetics; Magnesium Chloride; N-Methylaspartate; Neurotoxins; Pyrrolidinones; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Signal Transduction; Tumor Cells, Cultured | 1994 |