asparagine has been researched along with methotrexate in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (55.56) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakamura, N; Okada, S | 1 |
| Chlopkiewicz, B; Koziorowska, J | 1 |
| David, CL; Farnum, MF; Howell, EE; Kraut, J; Oatley, SJ; Villafranca, JE | 1 |
| Cole, DE; Holcenberg, JS; Jolivet, J; Poplack, DG | 1 |
| Appleman, JR; Blakley, RL; Howell, EE; Kraut, J; Kühl, M | 1 |
| Blakley, RL; Howell, EE; Kraut, J; London, RE; Warren, MS | 1 |
| Boisseau, M; Labatut, M; Moreau, F; Roulaud, F | 1 |
| Schindler, R | 1 |
| Bertino, JR; Capizzi, RL; Summers, WP | 1 |
| Bernard, J; Boiron, M; Bussel, A; Dreyfus, B; Jacquillat, C; Larrieu, MJ; Loisel, JP; Rouesse, T; Weil, M | 1 |
| Boyse, EA; Campbell, HA; Mashburn, LT; Old, LJ | 1 |
| Barsukov, IL; Basran, J; Casarotto, MG; Roberts, GC | 1 |
| Hussain, A; Melera, PW; Protzman, J; Yang, H | 1 |
| Akatsuka, J; Furukawa, T; Nakazawa, S; Nishimura, K; Ohira, M; Okawa, Y; Sugita, K; Tsuchida, M | 1 |
| Sugimura, K; Sukemori, S | 1 |
| González-Quevedo, A; Lima, L; Obregón, F; Roussó, T; Urbina, M | 1 |
| Arnold, R; Boos, J; Gökbuget, N; Hähling, D; Hartmann, F; Hoelzer, D; Ittel, TH; Langer, W; Mück, R; Müller, HJ; Peter, N; Rosen, O; Rothmann, F; Schwartz, S | 1 |
| Ahn, YC; Kim, SJ; Kim, WS; Ko, YH; Oh, D | 1 |
18 other study(ies) available for asparagine and methotrexate
| Article | Year |
|---|---|
Cell-cycle dependency of BUdR-induced mutation for six genetic markers in cultured mammalian cells.
Topics: Animals; Asparagine; Bromodeoxyuridine; Cell Cycle; Cytarabine; DNA; Drug Resistance; Genes; L Cells; Methotrexate; Mice; Mutation; Ouabain; Thioguanine; Thymidine | 1979 |
Role of amino acid depletion in combined treatment of neoplastic cells with methotrexate and L-asparaginase.
Topics: Animals; Asparaginase; Asparagine; Autoradiography; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; Haplorhini; L Cells; Leukemia L1210; Methotrexate; Neoplasms, Experimental | 1975 |
Structure and function of alternative proton-relay mutants of dihydrofolate reductase.
Topics: Asparagine; Binding Sites; Crystallography; Escherichia coli; Glutamates; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutagenesis, Site-Directed; Protons; Pteridines; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase | 1992 |
Prevention of methotrexate cytotoxicity by asparaginase inhibition of methotrexate polyglutamate formation.
Topics: Animals; Asparaginase; Asparagine; Biological Transport; Cell Survival; DNA Replication; Glutamates; Glutamic Acid; Glutamine; Kinetics; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Peptides; Polyglutamic Acid | 1985 |
Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli.
Topics: Asparagine; Aspartic Acid; Binding Sites; Escherichia coli; Kinetics; Mathematics; Methotrexate; Models, Theoretical; Mutation; Protein Binding; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase | 1988 |
Nuclear magnetic resonance study of the state of protonation of inhibitors bound to mutant dihydrofolate reductase lacking the active-site carboxyl.
Topics: Asparagine; Aspartic Acid; Binding Sites; Carbon Isotopes; Escherichia coli; Kinetics; Magnetic Resonance Spectroscopy; Methotrexate; Mutation; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1986 |
[Urinary elimination of beta aminoisobutyric acid in malignant hemopathies].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aminoisobutyric Acids; Asparagine; Child; Female; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Thymine; Vinblastine | 1971 |
[Molecular and cellular bases of cytostatic therapy].
Topics: Antibiotics, Antineoplastic; Antimetabolites; Asparaginase; Asparagine; Cell Division; Cell Line; Cells; DNA; DNA, Neoplasm; Humans; Methotrexate; Neoplasms; Nitrogen; Protein Biosynthesis; RNA; RNA, Neoplasm | 1974 |
L-asparaginase induced alteration of amethopterin (methotrexate) activity in mouse leukemia L5178Y.
Topics: Animals; Asparaginase; Asparagine; Cell Survival; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Female; Leukemia, Experimental; Methotrexate; Mice; Mice, Inbred Strains; Time Factors; Tritium | 1971 |
Treatment of acute leukemia with L-asparaginase--preliminary results on 84 cases.
Topics: Acute Disease; Asparaginase; Asparagine; Blood Coagulation Disorders; Cells, Cultured; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Daunorubicin; Humans; Kidney Diseases; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Liver Function Tests; Methotrexate; Prednisone; Valine; Vincristine | 1970 |
Suppression of murine leukemias by L-asparaginase. Incidence of sensitivity among leukemias of various types: comparative inhibitory activities of guinea pig serum L-asparaginase and Escherichia coli L-asparaginase.
Topics: Amidohydrolases; Animals; Antineoplastic Agents; Asparagine; Azaserine; Blood; Cyclophosphamide; Escherichia coli; Fluorouracil; Guinea Pigs; Leukemia, Experimental; Mercaptopurine; Methotrexate; Mice; Mitomycins; Prednisone; Vincristine | 1967 |
Role of the active-site carboxylate in dihydrofolate reductase: kinetic and spectroscopic studies of the aspartate 26-->asparagine mutant of the Lactobacillus casei enzyme.
Topics: Amino Acid Sequence; Asparagine; Aspartic Acid; Binding Sites; Escherichia coli; Folic Acid; Hydrogen-Ion Concentration; Kinetics; Lacticaseibacillus casei; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Oxidation-Reduction; Point Mutation; Spectrophotometry; Tetrahydrofolate Dehydrogenase | 1995 |
Selection for the expression of one form of Chinese hamster dihydrofolate reductase over another during growth in methotrexate.
Topics: Alleles; Animals; Asparagine; Aspartic Acid; Blotting, Southern; Cell Division; Cell Survival; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; DNA, Complementary; Methotrexate; Plasmids; Restriction Mapping; Selection, Genetic; Tetrahydrofolate Dehydrogenase; Transfection | 1994 |
High frequency of etoposide (VP-16)-related secondary leukemia in children with non-Hodgkin's lymphoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparagine; Child; Child, Preschool; Chromosome Aberrations; Chromosomes, Human, Pair 11; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Life Tables; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Neoplasms, Second Primary; Risk; Vincristine | 1993 |
Extracellular glutamine level reduction enhances 5-fluorouracil cytotoxicity.
Topics: Amino Acids; Animals; Asparagine; Cell Count; Dose-Response Relationship, Drug; Fluorouracil; Glutamine; Humans; Leukemia; Leukemia P388; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1998 |
Effects of taurine deficiency and chronic methanol administration on rat retina, optic nerve and brain amino acids and monoamines.
Topics: Amino Acids; Animals; Asparagine; beta-Alanine; Biogenic Monoamines; Brain; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Dopamine; Drinking; Folic Acid Deficiency; Hippocampus; Hydroxyindoleacetic Acid; Male; Methanol; Methotrexate; Optic Nerve; Rats; Rats, Sprague-Dawley; Retina; Serotonin; Taurine; Threonine | 2003 |
Pegylated asparaginase in combination with high-dose methotrexate for consolidation in adult acute lymphoblastic leukaemia in first remission: a pilot study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Blood Coagulation; Drug Administration Schedule; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 2003 |
Concurrent Chemoradiation Therapy Followed by Consolidation Chemotherapy for Localized Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparagine; Chemoradiotherapy; Cisplatin; Consolidation Chemotherapy; Dexamethasone; Disease-Free Survival; Dose Fractionation, Radiation; Drug Administration Schedule; Etoposide; Female; Humans; Ifosfamide; Lymphoma, Extranodal NK-T-Cell; Male; Methotrexate; Middle Aged; Nose Neoplasms; Radiotherapy, Conformal; Radiotherapy, Intensity-Modulated; Recurrence; Treatment Outcome | 2015 |